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Ultraviolet Keratitis

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1. Corneal Subbasal Nerve Recovery in an Acute Case of Ultraviolet Keratitis Treated with Autologous Serum Eye Drops (PubMed)

Corneal Subbasal Nerve Recovery in an Acute Case of Ultraviolet Keratitis Treated with Autologous Serum Eye Drops To report degeneration of subbasal corneal nerves and the subsequent neuroregeneration in a case of acute ultraviolet (UV) keratitis, treated with autologous serum eye drops.Case report.A 37-year-old female presented with ocular discomfort and blurred vision in both eyes, after exposure to UV-C light in a laboratory. On exam, she had bilateral conjunctival injection and superficial (...) punctate keratitis (SPK), worse in the left, consistent with acute, bilateral, but asymmetric UV-C keratitis. She was initially started on antibiotic ointment and lubricant eye drops. On her follow-up visit 3 days later, corneas had persistent SPK bilaterally. Laser scanning in vivo confocal microscopy (IVCM) showed beading of subbasal corneal nerves in the right eye and decreased subbasal corneal nerve density and numerous amputated nerves in the left eye. Autologous serum eye drops 20%, eight times

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2018 Journal of ophthalmology

2. Case series of keratitis in poultry abattoir workers induced by exposure to the ultraviolet disinfection lamp (PubMed)

Case series of keratitis in poultry abattoir workers induced by exposure to the ultraviolet disinfection lamp An outbreak of eye diseases occurred among workers at a poultry abattoir in South Korea from December 2012 to June 2013. An epidemiological investigation of the causative agent was conducted. The workers were given a special health examination and workplace environmental monitoring was performed. Workers with ocular symptoms subsequently underwent an ophthalmic examination.From a total (...) of 41 workers, 26 (63.4 %) were diagnosed with keratoepitheliopathy by ophthalmic examination. Environmental monitoring of the workplace revealed that the ultraviolet (UV) apron-disinfection lamp had not been turning off at the set times, and so the workers' faces had been exposed to UV radiation. Effective radiation dose measurement showed a UV-B exposure of 7-30 μW/cm(2), and a UV-C exposure of 40-200 μW/cm(2); both values exceed the occupational exposure limits. The outbreak ceased after the lamp

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2016 Annals of occupational and environmental medicine

3. Ultraviolet Keratitis

Ultraviolet Keratitis Ultraviolet Keratitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Ultraviolet Keratitis Ultraviolet (...) Keratitis Aka: Ultraviolet Keratitis , Snow Blindness , Ultraviolet Radiation Induced Photokeratitis , UV Photokeratitis , UV Keratitis , Photokeratitis From Related Chapters II. Pathophysiology l at high altitude III. Signs IV. Management ral Remove es affected eye Topical s to prevent infection Tobramycin Pain management Cool compresses ( ) eliminates ciliary spasm Ophthalmic S V. Prevention Sun glasses (UV protection, large lenses with side shields) Images: Related links to external sites (from Bing

2018 FP Notebook

4. Effect of Voriconazole and Ultraviolet-A Combination Therapy Compared to Voriconazole Single Treatment on Fusarium solani Fungal Keratitis (PubMed)

Effect of Voriconazole and Ultraviolet-A Combination Therapy Compared to Voriconazole Single Treatment on Fusarium solani Fungal Keratitis To demonstrate that ultraviolet-A (UV-A) and voriconazole combination therapy is more effective than voriconazole single treatment for fungal keratitis.The in vitro UV-A (375 nm) fungicidal effect was evaluated on Fusarium solani solutions. Each fungal solution was irradiated with different UV-A irradiation doses. Also, a fungal solution containing (...) voriconazole was also irradiated with UV-A. The in vivo therapeutic effect of UV-A and voriconazole treatment was studied in a rabbit keratitis model. Fungi were injected intrastromally into the cornea of 16 rabbits. Each treatment was initiated 3 days after fungal injection and continued up to 8 days for the following groups: Group 1, control; Group 2, treated with UV-A once a day; Group 3, treated with voriconazole 3 times a day; Group 4, treated with voriconazole 3 times a day and UV-A once a day

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2014 Journal of Ocular Pharmacology and Therapeutics

5. Ciclosporin (Verkazia) - Conjunctivitis, Keratitis

Ciclosporin (Verkazia) - Conjunctivitis, Keratitis 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5555 Send a question via our website www.ema.europa.eu/contact © European Medicines Agency, 2018. Reproduction is authorised provided the source is acknowledged. 20 July 2017 EMA/505143/2017 Committee for Medicinal Products for Human Use (CHMP) Assessment report Verkazia International non (...) Term QID Four times daily RH Relative Humidity RMP Risk Management Plan RS Randomised Set SAE Serious adverse event SmPC Summary of Product Characteristics SOC System organ class SS Safety Set TEAE Treatment-emergent adverse event Th2 Type 2 T helper cell TLC Thin layer chromatography ULOQ upper limit of quantification UV Ultraviolet VAS Visual Analog Scale VKC Vernal keratoconjunctivitis Assessment report EMA/505143/2017 Page 6/77 1. Background information on the procedure 1.1. Submission

2018 European Medicines Agency - EPARs

6. Ultraviolet Keratitis (Follow-up)

Ultraviolet Keratitis (Follow-up) Ultraviolet Keratitis Treatment & Management: Prehospital Care, Emergency Department Care, Consultations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNzk5MDI1LXRyZWF0bWVudA (...) == processing > Ultraviolet Keratitis Treatment & Management Updated: Mar 14, 2019 Author: Alex Koyfman, MD; Chief Editor: Liudvikas Jagminas, MD, FACEP Share Email Print Feedback Close Sections Sections Ultraviolet Keratitis Treatment Prehospital Care If ultraviolet (UV) keratitis is suspected, flush eyes for several minutes with water or saline solution. Next: Emergency Department Care Administration of a short-acting cycloplegic drop (eg, cyclopentolate 1%) may help relieve the pain of reflex ciliary

2014 eMedicine Emergency Medicine

7. Ultraviolet Keratitis (Treatment)

Ultraviolet Keratitis (Treatment) Ultraviolet Keratitis Treatment & Management: Prehospital Care, Emergency Department Care, Consultations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNzk5MDI1LXRyZWF0bWVudA (...) == processing > Ultraviolet Keratitis Treatment & Management Updated: Mar 14, 2019 Author: Alex Koyfman, MD; Chief Editor: Liudvikas Jagminas, MD, FACEP Share Email Print Feedback Close Sections Sections Ultraviolet Keratitis Treatment Prehospital Care If ultraviolet (UV) keratitis is suspected, flush eyes for several minutes with water or saline solution. Next: Emergency Department Care Administration of a short-acting cycloplegic drop (eg, cyclopentolate 1%) may help relieve the pain of reflex ciliary

2014 eMedicine Emergency Medicine

8. Ultraviolet Keratitis (Diagnosis)

Ultraviolet Keratitis (Diagnosis) Ultraviolet Keratitis: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNzk5MDI1LW92ZXJ2aWV3 processing > Ultraviolet Keratitis Updated (...) : Mar 14, 2019 Author: Alex Koyfman, MD; Chief Editor: Liudvikas Jagminas, MD, FACEP Share Email Print Feedback Close Sections Sections Ultraviolet Keratitis Overview Background Ultraviolet (UV) light is the most common cause of radiation injury to the eye. The cornea absorbs most UV radiation. UV radiation damage to the corneal epithelium is cumulative, similar to the effects with dermal epithelium (sunburn). Ozone in the atmosphere effectively filters most of the harmful UV radiation

2014 eMedicine Emergency Medicine

9. Ultraviolet Keratitis (Overview)

Ultraviolet Keratitis (Overview) Ultraviolet Keratitis: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNzk5MDI1LW92ZXJ2aWV3 processing > Ultraviolet Keratitis Updated: Mar (...) 14, 2019 Author: Alex Koyfman, MD; Chief Editor: Liudvikas Jagminas, MD, FACEP Share Email Print Feedback Close Sections Sections Ultraviolet Keratitis Overview Background Ultraviolet (UV) light is the most common cause of radiation injury to the eye. The cornea absorbs most UV radiation. UV radiation damage to the corneal epithelium is cumulative, similar to the effects with dermal epithelium (sunburn). Ozone in the atmosphere effectively filters most of the harmful UV radiation of wavelengths

2014 eMedicine Emergency Medicine

10. Cenegermin (Oxervate) - neurotrophic keratitis

Cenegermin (Oxervate) - neurotrophic keratitis 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5520 Send a question via our website www.ema.europa.eu/contact © European Medicines Agency, 2017. Reproduction is authorised provided the source is acknowledged. 18 May 2017 EMA/351805/2017 Committee for Medicinal Products for Human Use (CHMP) Assessment report OXERVATE International non (...) Eye Institute Visual Functioning Questionnaire 25 NGF Nerve growth factor NK Neurotrophic Keratitis NKCP Non-key process parameter NLT Not less than NMT Not more than OC Other concern OD Optical density Assessment report EMA/351805/2017 Page 6/104 OD600 Optical density at 600 nm p75 p75 (low affinity) neurotrophin receptor PC12 Pheochromocytoma rat cells PD Pharmacodynamics PED Persistent epithelial damage PEG Plyethylene glycol PETG Polytethylene terephthalate Ph. Eur. European Pharmacopoeia PK

2017 European Medicines Agency - EPARs

11. Comparison of corneal collagen cross-linking (PACK-CXL) and voriconazole treatments in experimental fungal keratitis. (PubMed)

, and it was observed that keratitis was formed on the third day. Both groups were randomly separated into the following four groups: control, PACK-CXL, voriconazole and PACK-CXL combined with voriconazole. PACK-CXL was applied using 0.25% riboflavin in an accelerated Dresden protocol (total ultraviolet A dose 5.4 J/cm²). Voriconazole was applied topically as 7x1/day with a dose of 1% (10 mg/ml). Corneal buttons were excised on the tenth day, and microbiological and pathological examinations were performed.The PACK (...) Comparison of corneal collagen cross-linking (PACK-CXL) and voriconazole treatments in experimental fungal keratitis. To compare the antifungal efficacy of corneal collagen cross-linking with photoactivated riboflavin (PACK-CXL) and voriconazole in experimental Fusarium solani and Candida albicans keratitis models.Sixty-four corneas of 32 New Zealand rabbits were included and divided into two main groups. Intrastromal injection of Fusarium and Candida suspensions was performed

2018 Acta ophthalmologica

12. Does PACK-CXL Change the Prognosis of Resistant Infectious Keratitis? (PubMed)

Does PACK-CXL Change the Prognosis of Resistant Infectious Keratitis? To examine the clinical characteristics, treatments, and prognosis of all cases of infectious keratitis resistant to conventional therapy and treated by photo-activated chromophore for keratitis corneal cross-linking (PACK-CXL) in one institution between 2012 and 2016.A database search of patients who underwent PACK-CXL (ultraviolet-A for 10 minutes for irradiance of 9 mW/cm2) for infectious keratitis unresponsive to medical

2018 Journal of Refractive Surgery

13. Photokeratitis (Ultraviolet [UV] burn, Arc eye, Snow Blindness)

Photokeratitis (Ultraviolet [UV] burn, Arc eye, Snow Blindness) Photokeratitis (Ultraviolet [UV] burn, Arc eye, Snow Blindness) submit The College submit You're here: Photokeratitis (Ultraviolet [UV] burn, Arc eye, Snow Blindness) Photokeratitis (Ultraviolet [UV] burn, Arc eye, Snow Blindness) The CMGs are guidelines on the diagnosis and management of a range of common and rare, but important, eye conditions that present with varying frequency in primary and first contact care. Share options (...) keratoconjunctivitis Contact or toxic keratitis Contact lens overwear Dry eye Foreign body Management by optometrist Practitioners should recognise their limitations and where necessary seek further advice or refer the patient elsewhere GRADE* Level of evidence and strength of recommendation always relates to the statement(s) immediately above Non pharmacological Reassure patient that damage is transitory symptoms will be gone within 24 to 48 hours (mild photophobia and blurring may persist for a week or longer

2015 College of Optometrists

14. Corneal Collagen Crosslinking Treatment in a Case with Pneumococcal Keratitis (PubMed)

Corneal Collagen Crosslinking Treatment in a Case with Pneumococcal Keratitis Bacterial keratitis is a serious ocular infectious disease that can threaten vision. The disease generally progresses rapidly and can lead to corneal scar, stromal abscess formation, perforation, and dissemination to adjacent tissues if not treated properly. Recent studies showed that corneal collagen crosslinking (CCC) using ultraviolet-A/riboflavin is effective in the treatment of bacterial keratitis refractory (...) to topical antibiotic treatment. In addition to being bactericidal, CCC also decreases risk of perforation by strengthening the corneal collagen structure. Herein, we report a male patient with Streptococcus pneumonia keratitis 6 months after a keratoplasty procedure, which did not respond to fortified topical antibiotic therapy and was treated successfully with riboflavin/ultraviolet-A CCC. His pain decreased remarkably in a few days. The corneal epithelial defect healed and infiltration regressed

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2017 Turkish Journal of Ophthalmology

15. Corneal Collagen Cross-linking for Treatment of Bacterial and Herpetic Keratitis (PubMed)

Corneal Collagen Cross-linking for Treatment of Bacterial and Herpetic Keratitis Optimal management of infective keratitis is a formidable challenge and subject of ongoing studies. Recently, Collagen Cross-Linking (CXL) of the cornea has been considered to be a new effective therapeutic approach for resistant infectious keratitis.Aim of the study was to evaluate the effectiveness of CXL with Ultraviolet-A (UV-A) and riboflavin for treatment of the refractory bacterial and Herpes Simplex Virus (...) (HSV) keratitis.In this prospective interventional study, eight patients with diagnosis of infectious keratitis who were referred to Khalili Hospital eye emergency room, between 2014 and 2015 were included in the study. There were six patients with bacterial keratitis and two patients with HSV keratitis; they were resistant to conventional treatment and underwent CXL. Response to the treatment was considered as good if rapid epithelialization and rapid decrease in stromal infiltration

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2017 Journal of clinical and diagnostic research : JCDR

16. Collagen Cross-Linking Using Riboflavin and Ultraviolet-A for Corneal Thinning Disorders

of complications. Complications such as infection and noninfectious keratitis (inflammatory response) reported in case reports generally occurred in the first week and were successfully treated with topical antibiotics and steroids. Other complications, such as the cytotoxic effects on the targeted corneal stroma, occurred as side effects of the photo-oxidative process generated by riboflavin and ultraviolet-A and were usually reversible. The reports on treatment effectiveness involved 15 pre-post longitudinal (...) Collagen Cross-Linking Using Riboflavin and Ultraviolet-A for Corneal Thinning Disorders OHTAC Recommendation Collagen Cross-Linking Using Riboflavin and Ultraviolet-A for Corneal Thinning Disorders November 2011 Collagen Cross-Linking For Corneal Thinning Disorders Ontario Health Technology Advisory Committee 2 Background The Ontario Health Technology Advisory Committee (OHTAC) met on June 24, 2011 to evaluate the effectiveness and safety of corneal collagen cross-linking using riboflavin

2011 Health Quality Ontario

17. Effect of Ultraviolet Light Irradiation Combined with Riboflavin on Different Bacterial Pathogens from Ocular Surface Infection (PubMed)

Effect of Ultraviolet Light Irradiation Combined with Riboflavin on Different Bacterial Pathogens from Ocular Surface Infection In order to study Staphylococcus epidermis and Staphylococcus aureus in vitro viability after the exposure to ultraviolet (UV) light and riboflavin, twelve strains of Staphylococcus epidermis and twelve strains of Staphylococcus aureus were isolated from patients with bacterial keratitis. The growth situation of Staphylococcus epidermidis and Staphylococcus aureus

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2017 Journal of Biophysics

18. Ultraviolet Keratitis

Ultraviolet Keratitis Ultraviolet Keratitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Ultraviolet Keratitis Ultraviolet (...) Keratitis Aka: Ultraviolet Keratitis , Snow Blindness , Ultraviolet Radiation Induced Photokeratitis , UV Photokeratitis , UV Keratitis , Photokeratitis From Related Chapters II. Pathophysiology l at high altitude III. Signs IV. Management ral Remove es affected eye Topical s to prevent infection Tobramycin Pain management Cool compresses ( ) eliminates ciliary spasm Ophthalmic S V. Prevention Sun glasses (UV protection, large lenses with side shields) Images: Related links to external sites (from Bing

2015 FP Notebook

19. Ultraviolet-A and Riboflavin Treatment for Infectious Keratitis

Ultraviolet-A and Riboflavin Treatment for Infectious Keratitis Ultraviolet-A and Riboflavin Treatment for Infectious Keratitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Ultraviolet-A and Riboflavin (...) to Brief Summary: This study is to evaluate the efficacy of ultraviolet-A (UVA) and riboflavin application (also often referred to as corneal collagen crosslinking) as a method to enhance treatment of infectious keratitis. Condition or disease Intervention/treatment Phase Infectious Keratitis Other: Ultraviolet-A and riboflavin Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 13 participants Intervention Model: Single

2012 Clinical Trials

20. PACK-CXL: Corneal cross-linking in infectious keratitis (PubMed)

PACK-CXL: Corneal cross-linking in infectious keratitis Corneal cross-linking (CXL) using ultraviolet light-A (UV-A) and riboflavin is a technique developed in the 1990's to treat corneal ectatic disorders such as keratoconus. It soon became the new gold standard in multiple countries around the world to halt the progression of this disorder, with good long-term outcomes in keratometry reading and visual acuity. The original Dresden treatment protocol was also later on used to stabilize (...) advanced infectious melting corneal keratitis. Patients treated with this technique showed, in the majority of cases, a stabilization of the melting process and were able to avoid emergent à chaud keratoplasty. Following those primary favorable results, CXL was used to treat beginning bacterial keratitis as a first-line treatment without any adjunctive antibiotics with positive results for most patients. In order to distinguish the use of CXL for infectious keratitis treatment from its use for corneal

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2016 Eye and Vision

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