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Tzanck Smear

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1. Tzanck Smear With Methylene Blue Stain for Herpes

Tzanck Smear With Methylene Blue Stain for Herpes Tzanck Smear With Methylene Blue Stain for Herpes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Tzanck Smear With Methylene Blue Stain for Herpes (...) Society of Thailand Information provided by (Responsible Party): Pawinee Rerknimitr, Chulalongkorn University Study Details Study Description Go to Brief Summary: To compare the sensitivity of Tzanck smear with methylene blue stain versus traditional Giemsa stain in patients with herpes infection. Condition or disease Intervention/treatment Phase Herpes Simplex Herpes Zoster Varicella Zoster Diagnostic Test: Methylene blue Diagnostic Test: Giemsa stain Phase 3 Detailed Description: A smear from

2017 Clinical Trials

2. Tzanck smear as an accurate and rapid diagnostic tool for cutaneous alternariosis in a renal transplant recipient. (PubMed)

Tzanck smear as an accurate and rapid diagnostic tool for cutaneous alternariosis in a renal transplant recipient. Alternaria species are becoming increasingly important opportunistic pathogens in recipients of solid organ transplant, as it has been shown that dissemination with systemic involvement is not as rare as previously reported. Therefore, rapid and accurate diagnosis is necessary for appropriate patient management. We report a patient with renal transplant who developed recurrent (...) cutaneous alternariosis. Tzanck smear successfully and very rapidly revealed hyphae and spores in both the primary and subsequent lesions. Furthermore, Tzanck smear provided guidance for histopathological examination of the second lesion, which failed to disclose the fungal elements until additional deeper serial sections were performed. The present case emphasizes that the Tzanck smear is a useful clinical tool leading to the immediate correct diagnosis even in deep fungal infections. © 2016 British

2016 Clinical & Experimental Dermatology

3. Tzanck Smear

Tzanck Smear Tzanck Smear Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Tzanck Smear Tzanck Smear Aka: Tzanck Smear , Tzanck (...) 1 minute Rinse off stain under gently water Put on a drop of immersion oil or Apply cover slip V. Examination of specimen Examine under 10x power Scan for smear bands Background of lightly stained debris Look for darkly stained cells Examine cells under 43x power Positive Test: Multinucleated Giant Cells (HSV) (VZV) Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Tzanck Smear." Click on the image (or right click) to open

2018 FP Notebook

4. Diagnostic reliability of the Tzanck smear in dermatologic diseases. (PubMed)

Diagnostic reliability of the Tzanck smear in dermatologic diseases. The Tzanck smear is a simple, easily applicable, rapid, and inexpensive test for the diagnosis of erosive vesiculobullous, tumoral, and granulomatous diseases. The diagnostic accuracy of the Tzanck smear is known, but its diagnostic reliability has been evaluated only in herpetic infections and basal cell carcinoma.The aim of this study was to evaluate the diagnostic reliability of the Tzanck smear in erosive vesiculobullous (...) , tumoral, and granulomatous diseases.Patients evaluated by Tzanck smear at Başkent University Faculty of Medicine, Department of Dermatology, between February 2009 and July 2010, were included. Three dermatologists were involved in the study. Dermatologist A performed a clinical dermatologic examination, took the smear material, made a clinical diagnosis, and compared the clinical and cytological diagnoses. Dermatologists B and C evaluated the smears. Agreement between the latter two dermatologists

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2013 International Journal of Dermatology

5. Tzanck Smear

Tzanck Smear Tzanck Smear Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Tzanck Smear Tzanck Smear Aka: Tzanck Smear , Tzanck (...) 1 minute Rinse off stain under gently water Put on a drop of immersion oil or Apply cover slip V. Examination of specimen Examine under 10x power Scan for smear bands Background of lightly stained debris Look for darkly stained cells Examine cells under 43x power Positive Test: Multinucleated Giant Cells (HSV) (VZV) Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Tzanck Smear." Click on the image (or right click) to open

2015 FP Notebook

6. Dermatoscopy versus Tzanck smear test: A comparison of the value of two tests in the diagnosis of pigmented skin lesions. (PubMed)

Dermatoscopy versus Tzanck smear test: A comparison of the value of two tests in the diagnosis of pigmented skin lesions. Dermatoscopy is the most commonly used noninvasive tool for the diagnosis of pigmented skin lesions, but few studies have investigated the value of cytology in the identification of those lesions.We compared the accuracy of dermatoscopy with that of the Tzanck smear test in the diagnosis of pigmented skin lesions, and in differentiating melanocytic from nonmelanocytic (...) lesions.Two dermatologists used either dermatoscopy or the Tzanck smear test to evaluate pigmented skin lesions, and the diagnostic accuracy of those methods was determined.Two hundred pigmented skin lesions (110 melanocytic and 90 nonmelanocytic) were evaluated. Cytology was superior to dermatoscopy in differentiating melanocytic pigmented lesions from nonmelanocytic pigmented lesions, but the overall diagnostic accuracy of those methods was the same (90.5%) for all lesions. The diagnostic accuracy

2011 Journal of American Academy of Dermatology

7. A Useful Alternative Approach for the Treatment of Well-Demarcated Basal Cell Carcinoma: Surgical Excision and Margin Control with Tzanck Smear Test. (PubMed)

A Useful Alternative Approach for the Treatment of Well-Demarcated Basal Cell Carcinoma: Surgical Excision and Margin Control with Tzanck Smear Test. To analyze the accuracy of the Tzanck smear test (TST) for margin control in surgery for well-demarcated basal cell carcinoma (BCC).Twenty-one patients with well-demarcated BCC were included in this study. After local anesthesia, the tumors were excised. The pathologist examined the frozen sections. If the tumor cells were observed in the margin (...) , a re-excision was done. This procedure was repeated until the margin was tumor free. After each excision, Tzanck smear samples were taken from the defect area. The samples obtained were stained with May-Grünwald-Giemsa and examined. The accuracy of TST was then analyzed by comparison of the TST results with those of frozen section examination.The sensitivity and specificity of TST for margin assessment were 1.00 (95% confidence interval (CI)=1.00-1.00) and 0.99 (95% CI=0.98-1.00), respectively

2010 Dermatologic Surgery

8. More experiences with the Tzanck smear test: cytologic findings in cutaneous granulomatous disorders. (PubMed)

More experiences with the Tzanck smear test: cytologic findings in cutaneous granulomatous disorders. Granulomatous dermatitis is a distinctive histopathologic cutaneous reaction pattern against various infectious and noninfectious agents. Cytologically, granulomatous dermatitis shows granulomas and multinucleated giant cells. Various etiologic agents of granulomatous diseases can also be identified.We aimed to investigate Tzanck smear findings in granulomatous skin diseases.Patients who had (...) granulomas and/or multinucleated giant cells of Langhans, foreign body- and/or Touton type in Tzanck smear tests were included in the study. In these patients, Tzanck preparations were then further evaluated for additional cytologic findings. Samples stained with May-Grünwald-Giemsa stain were evaluated by the same dermatologist throughout the study. In some patients, methylene blue, Gram and/or Erlich-Ziehl-Nielsen stains were also performed. In all of the study cases, the final diagnosis

2009 Journal of American Academy of Dermatology

9. Acute varicella-zoster

/malaise sore throat tachycardia age 1 to 9 years exposure to varicella unimmunised status occupational exposure Diagnostic investigations clinical diagnosis polymerase chain reaction viral culture direct fluorescent antibody testing (DFA) Tzanck smear latex agglutination (LA) enzyme-linked immunosorbent assay (ELISA) complement fixation ultrasound (pregnant women) Treatment algorithm ACUTE Contributors Authors Consultant in Paediatric Infectious Diseases and Immunology Royal Liverpool Children's

2019 BMJ Best Practice

10. Exfoliative cytology for diagnosing basal cell carcinoma and other skin cancers in adults. (PubMed)

cytology is a non-invasive test that uses the Tzanck smear technique to identify disease by examining the structure of cells obtained from scraped samples. This simple procedure is a less invasive diagnostic test than a skin biopsy, and for BCC it has the potential to provide an immediate diagnosis that avoids an additional clinic visit to receive skin biopsy results. This may benefit patients scheduled for either Mohs micrographic surgery or non-surgical treatments such as radiotherapy. A cytology

2018 Cochrane

11. Paronychia

) missing cuticle (chronic) underlying nail plate abnormalities (chronic) microscopic or macroscopic injury to the nail folds (acute) occupational risks (acute and chronic) barrier damage to the nail folds, cuticle (chronic) ingrown nail chemotherapeutic agents toddler and adult female Diagnostic investigations swab for Gram stain, culture, and sensitivity (acute or acute-on-chronic) swab for Tzanck smear (acute, herpetic) potassium hydroxide or fungal culture (chronic) x-ray MRI biopsy of skin/bone

2018 BMJ Best Practice

12. Folliculitis

in the submaxillary area small, uniform papules and pustules background erythema alopecia/scalp scaling erythematous plaques with haemorrhagic crusts in a dermatomal distribution trauma, including shaving and extraction occlusion perspiration topical corticosteroid preparations systemic antibiotics diabetes mellitus immunosuppression immersion in underchlorinated water drugs Diagnostic investigations Gram stain potassium hydroxide (KOH) preparation Tzanck smear direct fluorescent antibody (DFA) assay tissue

2018 BMJ Best Practice

13. Acute varicella-zoster

/malaise sore throat tachycardia age 1 to 9 years exposure to varicella unimmunised status occupational exposure Diagnostic investigations clinical diagnosis polymerase chain reaction viral culture direct fluorescent antibody testing (DFA) Tzanck smear latex agglutination (LA) enzyme-linked immunosorbent assay (ELISA) complement fixation ultrasound (pregnant women) Treatment algorithm ACUTE Contributors Authors Consultant in Paediatric Infectious Diseases and Immunology Royal Liverpool Children's

2018 BMJ Best Practice

14. Miliaria

episodes of miliaria rubra (for miliaria profunda) ultraviolet light exposure neonatal age cholinergic medicines isotretinoin doxorubicin staphylococcal scalded skin syndrome atopic dermatitis Diagnostic investigations Tzanck smear viral direct fluorescent antibody (DFA) or culture viral PCR bacterial culture fungal culture potassium hydroxide (KOH) preparation skin biopsy Treatment algorithm ACUTE Contributors Authors Clinical Associate Professor Departments of Dermatology and Pathology Iowa City

2018 BMJ Best Practice

15. A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiology

designed for enhanced yield of yeast (eg, MycoF/Lytic [BD Diagnostics, Sparks, Maryland]) or lysis-centrifugation may be used. h Some dimorphic fungi and yeasts (eg, Malassezia spp) may be visualized on peripheral blood smears in some patients using one of a variety of fungal stains. Such requests should be made in consultation with the microbiology laboratory director. Table 2. Blood Culture Laboratory Diagnosis Organized by Etiological Agent Etiologic Agents Diagnostic Procedures Optimum Specimens (...) cultures to inoculate at least 1 blood specimen into 2 aerobic vials rather than the customary aerobic and anaerobic vial pair. Alternatively, a broth medium designed for enhanced yield of yeast (eg, MycoF/Lytic [BD Diagnostics, Sparks, Maryland]) or lysis-centrifugation may be used. h Some dimorphic fungi and yeasts (eg, Malassezia spp) may be visualized on peripheral blood smears in some patients using one of a variety of fungal stains. Such requests should be made in consultation

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2018 Infectious Diseases Society of America

16. NASPGHAN Clinical Report: Surveillance, Diagnosis, and Prevention of Infectious Diseases in Pediatric Patients with Inflammatory Bowel Disease Receiving Tumor Necrosis Factor - alpha Inhibitors

sensitivity compared with viral culture and Tzanck smear (136). VZV can be detected by PCR in whole blood during acute episodes of both primary varicella and herpes zoster but is less sensitive than testing of scrapings of skin lesions. VZV PCR may also be performed on CSF in the presence of encephalitis but is infrequently positive. Serology is not reliable in immunocompromised hosts to confirm acute infection but should be used for initial screening before immunosuppressive therapy is initiated (see (...) -TNFa therapy. If a patient has already been diag- nosed and treated for LTBI, then annual screening should include careful assessment of possible exposures, symptoms, and a chest X-ray, as clinically indicated. Prevention/Isolation/Control Measures. Airborne isolation plus standard precautions are recommended for active M. tuberculosis disease, including those with cavitary pulmonary tuberculosis or extensive pulmonary disease, positive sputum AFB smears, and children undergoing procedures

2016 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

17. MKSAP: 20-year-old male college student with a superficial skin infection

examination is unremarkable. Which of the following is the most appropriate next step in management? A. Culture a pustule B. Perform a Tzanck smear C. Start linezolid D. Start vancomycin MKSAP Answer and Critique The correct answer is A. Culture a pustule. The most appropriate first step in management is to culture a pustule to identify the causative organism prior to institution of antibiotic therapy. Bacterial skin infections are most commonly caused by Staphylococcus and Streptococcus spp. and may (...) be a treatment option (put 1/4 to 1/2 cup of common liquid bleach into the bath water to create a chlorinated bath), which decreases colonization of S. aureus ). A Tzanck smear can be performed if a herpes simplex virus or varicella infection is suspected. Both infections can occur in wrestlers but would typically present as painful vesicles or punched-out erosions as opposed to furuncles or folliculitis. Linezolid is effective against many strains of MRSA and streptococci. However, its use should be limited

2017 KevinMD blog

18. Bedside diagnostics in dermatology: Parasitic and noninfectious diseases. (PubMed)

Bedside diagnostics in dermatology: Parasitic and noninfectious diseases. In addition to aiding the diagnosis of viral, bacterial, and fungal diseases, mineral oil preparation, Tzanck smear, and other techniques can be used to diagnose parasitic infections, neonatal pustular dermatoses, blistering diseases, Stevens-Johnson syndrome, and a plethora of other benign and malignant conditions, including granulomatous diseases and tumors. In many cases, these techniques are specific, reliable

2017 Journal of American Academy of Dermatology

19. Herpesviradae infections in severely burned children (PubMed)

smear, viral culture, and/or PCR. Study endpoints were mortality, days of antiviral agent administration, type of viral test used, type of viral infection, and length of hospitalization.Of the 613 patients were analyzed, 28 presented with clinically diagnosed viral infections. The use of Tzanck smears decreased over the past 5 years, whereas PCR and viral cultures have become standard. Patients with viral infections had significantly larger burns (53±15% vs. 38±18%, p<0.001); however, length of stay (...) Herpesviradae infections in severely burned children Burn-related immunosuppression can promote human herpesviridae infections. However, the effect of these infections on morbidity and mortality after pediatric burn injuries is unclear.We retrospectively analyzed pediatric patients with burns ≥10% of the total body surface area (TBSA) who were admitted between 2010 and 2015. On clinical suspicion of a viral infection, antiviral therapy was initiated. Viral infection was confirmed via Tzanck

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2017 Burns : journal of the International Society for Burn Injuries

20. Delayed Diagnosis of Basal Cell Carcinoma of the Upper Lip: The Possible Role of Incidental Multinucleated Foreign Body Giant Cells (PubMed)

Delayed Diagnosis of Basal Cell Carcinoma of the Upper Lip: The Possible Role of Incidental Multinucleated Foreign Body Giant Cells Herpes simplex and basal cell carcinoma (BCC) can have similar clinical presentations due to overlapping lesional morphology. We describe the unusual case of a BCC masquerading as herpes labialis due to a possible false-positive Tzanck smear. The confounding diagnosis led to a failed trial of valacyclovir and subsequent loss of the patient for 1 year before

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2017 Case reports in dermatology

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