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Insulin Glargine Dose and Weight Changes in Underweight, Normal Weight, and Overweight Children Newly Diagnosed with Type1DiabetesMellitus. Newly diagnosed pediatric patients with type1diabetesmellitus (T1D) can be underweight, overweight, or normal weight at presentation. Study objectives were to determine if, across weight categories, admission body weight (ABW)-based initial insulin glargine dosing resulted in similar fasting blood glucose responses on day of discharge, how initial ABW
A new strategy for vascular complications in young people with type1diabetesmellitus. Diabetes vascular complications, including cardiovascular disease, diabetic nephropathy and retinopathy, have a negative effect on the long-term prognosis of young people with type1diabetesmellitus (T1DM). Poor glycaemic control and consequent increased HbA1c levels are major risk factors for the development of vascular complications. HbA1c levels are the main focus of current management strategies
Albuminuria, the High-Density Lipoprotein Proteome, and Coronary Artery Calcification in Type1DiabetesMellitus. Objective- Albuminuria is an important risk factor for cardiovascular disease in diabetesmellitus. We determined whether albuminuria associates with alterations in the proteome of HDL (high-density lipoprotein) of subjects with type1diabetesmellitus and whether those alterations associated with coronary artery calcification. Approach and Results- In a cross-sectional study (...) ). Furthermore, PON (paraoxonase) 1 and PON3 levels in HDL strongly and negatively associated with the presence of coronary artery calcium, with odds ratios per 1-SD difference of 0.63 (95% CI, 0.43-0.92; P=0.018) for PON1 and 0.59 (95% CI, 0.40-0.87; P=0.0079) for PON3. Only 1 protein, PON1, associated with both albumin excretion rate and coronary artery calcification. Conclusions- Our observations indicate that the HDL proteome is remodeled in type1diabetesmellitus subjects with albuminuria. Moreover
Relationship of four vitamin D receptor gene polymorphisms with type1diabetesmellitus susceptibility in Kuwaiti children. The incidence of type1diabetesmellitus (T1DM) in Kuwait is amongst the highest in the world. Vitamin D is considered to be involved in immune modulation and its deficiency contribute to autoimmune destruction of insulin producing beta cells in T1DM patients. Vitamin D has been shown to exert its effects via a nuclear vitamin D receptor (VDR) and therefore, VDR gene may
Pharmacologic strategies to reduce cardiovascular disease in type 2 diabetesmellitus: focus on SGLT-2 inhibitors and GLP-1 receptor agonists. Patients with type 2 diabetesmellitus (T2D) present an increased risk for cardiovascular (CV) complications. In addition to improvement in glycaemic control, glucose-lowering therapies, such as glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-dependent glucose cotransporter (SGLT)-2 inhibitors, have been shown to significantly reduce CV
Different patterns of electroencephalography during hypoglycemia in type1diabetesmellitus: A case report. Electroencephalographic (EEG) changes are frequently observed not only by epileptic seizures but also by metabolic encephalopathies. The EEG changes during hypoglycemia are known as mixed frequency theta to delta activity with higher amplitude than the initial background rhythm. Although there are many reports about hypoglycemia induced EEG changes, few studies of hypoglycemic EEG (...) patterns have been evaluated between arousal and sleep stage.A 45-year-old man who had been diagnosed as type1diabetesmellitus for 15 years admitted to the emergency room due to seizure attack. The EEG findings of the patient showed increased amplitude of theta slowing on both hemispheres. The abnormal EEG finding had recovered and the background frequency remarkably increased as the patient fell asleep, but reappeared when he woke up.The patient was diagnosed as hypoglycemia with altered
Subclinical Auditory Neural Deficits in Patients With Type1DiabetesMellitus. Diabetesmellitus (DM) is associated with a variety of sensory complications. Very little attention has been given to auditory neuropathic complications in DM. The aim of this study was to determine whether type1DM (T1DM) affects neural coding of the rapid temporal fluctuations of sounds, and how any deficits may impact on behavioral performance.Participants were 30 young normal-hearing T1DM patients, and 30 age
Intervention in emotional abilities for adolescents with type1diabetesmellitus in a hospital setting: a study protocol for a randomised controlled trial. Type1diabetesmellitus (T1DM) is one of the most frequent chronic endocrine diseases in the paediatric population. As a result, this disease has a strong impact on psychological well-being. In line with this, emotional factors play an important role in adaptation. The aim of the present study protocol is to design an emotional abilities
Efficacy and safety of a rosehip seed oil extract in the prevention and treatment of skin lesions in the hands of patients with type1diabetesmellitus caused by finger prick blood glucose monitoring; a randomized, open-label, controlled clinical trial. This study was intended to assess the efficacy and safety of a rosehip seed oil (RHO) extract in the prevention and treatment of skin lesions in the hands of patients with type1diabetesmellitus (T1DM) caused by finger prick blood glucose
Clinical efficacy of Professional Continuous Glucose Monitoring in improving glycemic control among children with Type1DiabetesMellitus: An Open-label Randomized Control Trial. Frequent self-monitoring of blood glucose (SMBG) is the only accurate method available for insulin dose titration in patients with T1DM. Professional continuous glucose monitoring (p-CGM) is blinded recording of glucose trends over 5-7 days and helps physicians to guide insulin titration to patient. This study
Comparison of adjunctive therapy with metformin and acarbose in patients with Type-1diabetesmellitus. All the aforementioned data have stimulated interest in studying other potential therapies for T1DM including noninsulin pharmacological therapies. The present study attempts to investigate the effect of adjunctive therapy with metformin and acarbose in patients with Type-1diabetes mellitus.In a single-center, placebo-controlled study (IRCT201102165844N1) we compared the results of two (...) clinical trials conducted in two different time periods on 40 patients with Type-1diabetesmellitus. In the first section, metformin was given to the subjects. After six months, metformin was replaced with acarbose in the therapeutic regimen. In both studies, subjects were checked for their BMI, FBS, HbA1C, TGs, Cholesterol, LDL, HDL, 2hpp, unit of NPH and regular insulin variations.Placebo-controlled evaluation of selected factors has showna significant decrease in FBS and TG levels in the metformin
The Effects of Adiponectin and Adiponectin Receptor 1 Levels on Macrovascular Complications Among Patients with Type 2 DiabetesMellitus. The present study aimed to investigate the serum levels of adiponectin (APN) and adiponectin receptor 1 (AdipoR1) in patients with type 2 diabetesmellitus (T2DM) combined with macrovascular complications (MVC), as well as their correlation with clinical parameters.A total of 60 T2DM patients were divided into 2 groups according to the presence of MVC: T2DM
Effect of PPARÎ³ agonist on aerobic exercise capacity in relation to body fat distribution in men with type 2 diabetesmellitus and coronary artery disease: a 1-yr randomized study. Targeting metabolic determinants of exercise performance with pharmacological agents that would mimic/potentiate the effects of exercise represents an attractive clinical alternative to counterbalance the poor exercise capacity in patients with type 2 diabetesmellitus (T2DM). We examined the effect of 1-yr (...) treatment with the insulin sensitizer peroxisome proliferator-activated receptor (PPAR)γ agonist rosiglitazone on aerobic exercise capacity and body fat composition/distribution in men with T2DM and stable coronary artery disease (CAD). One-hundred four men (age: 64 ± 7 yr; body mass index: 30.0 ± 4.4 kg/m2) with T2DM and CAD were randomized to receive rosiglitazone or placebo for 1 yr. Aerobic exercise capacity (exercise duration) was assessed with a maximal treadmill test, and body composition
A randomized controlled trial comparing a telemedicine therapeutic intervention with routine care in adults with type1diabetesmellitus treated by insulin pumps. To examine the effectiveness and safety over a 12-month period of a telemedicine intervention in adults with type1diabetes (T1D) treated with insulin pumps.74 T1D patients on insulin pumps for at least 1 year (mean 19.5 [11.5] years) and HbA1c ≥ 6.5% (≥ 48 mmol/mol) were randomized to the telemedicine (n = 37) or the standard care (...) in adults with type1diabetes treated by insulin pumps. For suitable patients, some of the time-consuming routine visits may be replaced by user-friendly digital medicine.Clinical Trial.gov Identifier NCT01887431.
RETINAL HYPERREFLECTIVE FOCI IN TYPE1DIABETESMELLITUS. To investigate hyperreflective foci (HF) on spectral-domain optical coherence tomography in patients with Type1diabetesmellitus across different stages of diabetic retinopathy (DR) and diabetic macular edema (DME) and to study clinical and morphological characteristics associated with HF.Spectral-domain optical coherence tomography scans and color fundus photographs were obtained of 260 patients. Spectral-domain optical coherence (...) was only reached for moderate nonproliferative DR (P = 0.001) and proliferative DR (P = 0.019). Higher numbers of HF were associated with longer diabetes duration (P = 0.029), lower high-density lipoprotein cholesterol (P = 0.005), and the presence of microalbuminuria (P = 0.005). In addition, HF were associated with morphological characteristics on spectral-domain optical coherence tomography, including central retinal thickness (P = 0.004), cysts (P < 0.001), subretinal fluid (P = 0.001
Greater Suppression of Glucagon, Lipolysis, and Ketogenesis with Insulin Glargine U300 as Compared with Glargine U100 in Type1DiabetesMellitus. The aim of this study was to establish the effects of clinical doses of Gla-300 versus Gla-100 on suppression of glucagon, lipolysis, and ketogenesis in type1diabetesmellitus (T1DM). Eighteen persons with T1DM (age 40 ± 12 years, diabetes duration 26 ± 12 years, body mass index 23.4 ± 2 kg/m2, A1C 7.19% ± 0.52% [55 ± 6 mmol/mol]) were studied (...) after 3 months of titration with Gla-300 and Gla-100 (randomized, crossover design) with a 24-h euglycemic clamp (s.c. injection of individual insulin daily doses used by subjects for previous 2 weeks, Gla-300 0.35 ± 0.08 and Gla-100 0.28 ± 0.07 U/kg). Gla-300 resulted in (1) less increase in insulin concentration for 0-12 h, but greater insulin concentration in 12-24 h (no differences for 24 h); (2) greater glucagon suppression; (3) greater prehepatic insulin-to-glucagon molar ratio, primarily
Evaluating a dietary pattern in adolescents with type1diabetesmellitus: The dash-d approach. Adolescents with type1diabetes (T1DM) must consider multiple factors in diet planning, including glycemic control and cardiovascular disease prevention, while ensuring adequate nutrition for growth. We examined diet composition, quality, and compliance for two dietary patterns - the traditional Dietary Approaches to Stop Hypertension (DASH) and a modified version of DASH in this population.Two (...) feeding studies were conducted. First, adolescents with T1DM consumed their usual diet for 3 days followed by traditional DASH for 6 days. Next, DASH menus were adjusted to align with T1DM nutrition guidelines, and this modified DASH for Diabetes (DASH-D) was tested on a new group of adolescents with T1DM for 6 days, following 3 days of usual diet. Usual diet was measured via 24-hr dietary recalls. Dietary composition of DASH-D was compared to DASH and usual diet. Eighteen adolescents (9/group
Effects of type1diabetesmellitus on efferent auditory system in children and adolescents. To investigate whether type1diabetesmellitus (T1DM) could affect the efferent auditory system by analyzing the relationship between the activation of the medial olivocochlear reflex with disease duration, metabolic control and age at time of diagnosis.A total of 101 children and adolescents were evaluated. They were divided into two groups: 50 with T1DM and 51 without the disease. The participants
Stiff Person Syndrome and Type1DiabetesMellitus: a Case of the Chicken or the Egg? Anti-glutamic acid decarboxylase (anti-GAD) antibodies are linked with both autoimmune diabetes and the rare neurological disorder stiff person syndrome (SPS). SPS is an uncommon autoimmune-mediated condition characterized by painful episodic spasms and progressive muscle rigidity. We present the case of a 23-year-old non-diabetic, insulin-naïve woman with known SPS who was hospitalized for SPS-related (...) symptomatology. The patient quickly developed type1diabetesmellitus (T1DM) with unexpectedly large insulin requirements. To our knowledge, there are no other reports describing rapid T1DM development during an acute hospitalization for SPS and fewer than 5 case reports describing the association of SPS with extreme insulin resistance. Our case highlights the key clinical features, pathology, and pathogenesis of both SPS and T1DM and explores the relationship between the two disease processes.