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Type 1 Diabetes Mellitus

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101. Incidence of fractures in patients with type 1 diabetes mellitus-a retrospective study with 4420 patients. (Abstract)

Incidence of fractures in patients with type 1 diabetes mellitus-a retrospective study with 4420 patients. This retrospective study investigated the incidence of fracture in 4420 type 1 diabetes (T1DM) patients. Our findings indicate that patients with T1DM have an increased incidence of fractures. Further studies and preventive measures are urgently needed.The aim of this study was to investigate the incidence of fracture in patients with type 1 diabetes mellitus (T1DM).This study is based (...) on the German Disease Analyzer database and included 4258 adult individuals with a T1DM diagnosis documented between January 2000 and December 2015 in 1203 general practices in Germany. Individual matching of T1DM and non-diabetic patients was performed. The cumulative incidence of new fractures was shown for up to 10 years after the index date using Kaplan-Meier curves. Cox proportional hazard models (dependent variable: incident fracture) were used to estimate the effect of T1DM on fracture incidence

2020 Osteoporosis International

102. Web-based intervention for depressive symptoms in adults with types 1 and 2 diabetes mellitus: a health economic evaluation Full Text available with Trip Pro

Web-based intervention for depressive symptoms in adults with types 1 and 2 diabetes mellitus: a health economic evaluation Web-based interventions are effective in reducing depression. However, the evidence for the cost-effectiveness of these interventions is scarce.AimsThe aim is to assess the cost-effectiveness of a web-based intervention (GET.ON M.E.D.) for individuals with diabetes and comorbid depression compared with an active control group receiving web-based psychoeducation.We (...) -effective.This web-based intervention for individuals with diabetes and comorbid depression demonstrated a high probability of being cost-effective compared with an active control group.Declaration of interestS.N., D.D.E., D.L., M.B. and B.F. are stakeholders of the Institute for Online Health Trainings, which aims to transfer scientific knowledge related to this research into routine healthcare.

2018 EvidenceUpdates

103. ABCD position statement on standards of care for management of adults with type 1 diabetes

is also available which includes a short summary of the recommendations from each section. The sections on inpatient care and management of diabetic emergencies are particularly relevant today. We are grateful to all the contributors. Discipline: Diabetes Clinical taxonomy: Type 1 diabetes mellitus Resource taxonomy: Guidelines Position Paper Information for HCPs Follow Us Address for correspondence: ABCD (Diabetes Care) Ltd, Miria House, 1683b High Street, Knowle, Solihull, West Midlands, B93 0LL (...) ABCD position statement on standards of care for management of adults with type 1 diabetes Standards of Care for Management of Adults with Type 1 Diabetes | ABCD (Diabetes Care) Ltd You are here: Standards of Care for Management of Adults with Type 1 Diabetes 2020 ABCD Standards of care for the management of adults with type 1 diabetes provides comprehensive standards for units providing care to people with type 1 diabetes and is intended as a resource for specialist teams. A summary document

2020 Association of British Clinical Diabetologists

104. Insulin pumps for people with Type 1 Diabetes

with type 1 diabetes mellitus: o who use multiple daily injections of insulin (MDI) to achieve target HbA1c but result in the person experiencing disabling hypoglycaemia, where disabling hypoglycaemia is defined as the repeated and unpredictable occurrence of hypoglycaemia that results in persistent anxiety about recurrence and is associated with a significant adverse effect on quality of life (QoL); or o who have unacceptably high HbA1c (i.e. at 8.5% or above) on MDI despite a high level of care, where (...) Driving better decision-making in healthcare Factors considered to inform the recommendations for subsidy Technology evaluation 1.1 The MOH MTAC (“the Committee”) considered evidence presented for the evaluation of continuous subcutaneous insulin infusion therapy (CSII) for the treatment of people with type 1 diabetes mellitus (T1DM). The evaluation was conducted in consultation with clinical experts from the public healthcare institutions. Available clinical and economic evidence for CSII

2020 Appropriate Care Guides, Agency for Care Effectiveness (Singapore)

105. Sodium-glucose co-transporter 2 (SGLT2) inhibitors for type 2 diabetes mellitus

Sodium-glucose co-transporter 2 (SGLT2) inhibitors for type 2 diabetes mellitus '); } else { document.write(' '); } ACE | Sodium-glucose co-transporter 2 (SGLT2) inhibitors for type 2 diabetes mellitus Search > > Sodium-glucose co-transporter 2 (SGLT2) inhibitors for type 2 diabetes mellitus - Sodium-glucose co-transporter 2 (SGLT2) inhibitors for type 2 diabetes mellitus First published on 3 May 2017 Guidance Recommendations The Ministry of Health’s Drug Advisory Committee has recommended (...) : Dapagliflozin 5 mg and 10 mg tablets, and empagliflozin 10 mg and 25 mg tablets for managing type 2 diabetes mellitus, in the following circumstances: as a dual therapy in combination with metformin for patients with HbA1c measurement greater than 7% despite treatment with metformin monotherapy and when sulfonylureas are contraindicated or not tolerated, or the person is at significant risk of hypoglycaemia or its consequences; or as a dual therapy in combination with a sulfonylurea for patients with HbA1c

2018 Appropriate Care Guides, Agency for Care Effectiveness (Singapore)

106. Hemoglobin A1c Targets for Glycemic Control With Pharmacologic Therapy for Nonpregnant Adults With Type 2 Diabetes Mellitus: A Guidance Statement Update From the American College of Physicians Full Text available with Trip Pro

conditions, or long-standing DM [diabetes mellitus] in which the A1C goal has been difficult to attain despite intensive efforts, so long as the patient remains free of polydipsia, polyuria, polyphagia, and other hyperglycemia-associated symptoms (Grade A; BEL 1). ( ) Comments According to the AACE/ACE grading scheme, “Grade A; BEL 1” indicates highest-quality evidence with little or no effect from subjective factors on recommendation (evidence mapped to recommendation) and “Grade D; BEL 4” indicates (...) Hemoglobin A1c Targets for Glycemic Control With Pharmacologic Therapy for Nonpregnant Adults With Type 2 Diabetes Mellitus: A Guidance Statement Update From the American College of Physicians ACP Guidance Statement on HbA | Annals of Internal Medicine | American College of Physicians '); } Sign in below to access your subscription for full content INDIVIDUAL SIGN IN | You will be directed to acponline.org to register and create your Annals account INSTITUTIONAL SIGN IN | | Subscribe to Annals

2018 American College of Physicians

107. Semaglutide (Ozempic) for the treatment of adults with insufficiently controlled type 2 diabetes mellitus as an adjunct to diet and exercise

English part of National Health Care Institute Search Semaglutide (Ozempic®) for the treatment of adults with insufficiently controlled type 2 diabetes mellitus as an adjunct to diet and exercise Zorginstituut Nederland carried out a marginal assessment of whether semaglutide (Ozempic®) is interchangeable with a drug currently included in the Medicine Reimbursement System (GVS). Registration Semaglutide belongs to the pharmacotherapeutic group of GLP-1 (glucagon-like peptide 1) receptor agonists (...) Semaglutide (Ozempic) for the treatment of adults with insufficiently controlled type 2 diabetes mellitus as an adjunct to diet and exercise Semaglutide (Ozempic®) for the treatment of adults with insufficiently controlled type 2 diabetes mellitus as an adjunct to diet and exercise | Report | National Health Care Institute You are here: Semaglutide (Ozempic®) for the treatment of adults with insufficiently controlled type 2 diabetes mellitus as an adjunct to diet and exercise Search within

2018 National Health Care Institute (Zorginstituut Nederland)

108. Type 1 diabetes

Type 1 diabetes Type 1 diabetes - Symptoms, diagnosis and treatment | BMJ Best Practice   Search  Type 1 diabetes Last reviewed: February 2019 Last updated: March 2018 Summary Type 1 diabetes mellitus is a metabolic disorder characterised by hyperglycaemia due to absolute insulin deficiency. Patients most often present with a few days or weeks of polyuria, polydipsia, weight loss, and weakness. Some patients may present with diabetic ketoacidosis. Intensive glycaemic control has been shown (...) to decrease the incidence of microvascular and macrovascular complications. Microvascular complications include retinopathy, nephropathy, and neuropathy. Macrovascular complications include coronary artery, cerebrovascular, and peripheral vascular disease. Definition Type 1 diabetes mellitus is a metabolic disorder characterised by hyperglycaemia due to absolute insulin deficiency. The condition develops due to destruction of pancreatic beta cells, mostly by immune-mediated mechanisms. In some patients

2018 BMJ Best Practice

109. Reparixin for prevention of delayed graft function in pancreatic islet transplantation for type 1 diabetes mellitus

Reparixin for prevention of delayed graft function in pancreatic islet transplantation for type 1 diabetes mellitus Reparixin for prevention of delayed graft function in pancreatic islet transplantation for type 1 diabetes mellitus Reparixin for prevention of delayed graft function in pancreatic islet transplantation for type 1 diabetes mellitus NIHR HSRIC Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation (...) of the quality of this assessment has been made for the HTA database. Citation NIHR HSRIC. Reparixin for prevention of delayed graft function in pancreatic islet transplantation for type 1 diabetes mellitus. Birmingham: NIHR Horizon Scanning Research&Intelligence Centre. Horizon Scanning Review. 2016 Authors' conclusions Type 1 diabetes happens when the cells that make insulin in the pancreas, the islets, are destroyed. Islet cell transplantation involves extracting islet cells from the pancreas

2016 Health Technology Assessment (HTA) Database.

110. Pancreas islet transplantation for patients with type 1 diabetes mellitus: a clinical evidence review

Pancreas islet transplantation for patients with type 1 diabetes mellitus: a clinical evidence review Pancreas islet transplantation for patients with type 1 diabetes mellitus: a clinical evidence review Pancreas islet transplantation for patients with type 1 diabetes mellitus: a clinical evidence review Health Quality Ontario Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been (...) made for the HTA database. Citation Health Quality Ontario. Pancreas islet transplantation for patients with type 1 diabetes mellitus: a clinical evidence review. Toronto: Health Quality Ontario (HQO). Ontario health technology assessment series; 15(16). 2015 Authors' conclusions Islet transplantation offers an alternative for patients with type 1 diabetes who have brittle diabetes with difficult-to-control blood glucose levels or hypoglycemic unawareness despite optimal insulin therapy. Treatment

2016 Health Technology Assessment (HTA) Database.

111. Pancreas islet transplantation for patients with type 1 diabetes mellitus: OHTAC recommendation

Pancreas islet transplantation for patients with type 1 diabetes mellitus: OHTAC recommendation Pancreas islet transplantation for patients with type 1 diabetes mellitus: OHTAC recommendation Pancreas islet transplantation for patients with type 1 diabetes mellitus: OHTAC recommendation Health Quality Ontario Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA (...) database. Citation Health Quality Ontario. Pancreas islet transplantation for patients with type 1 diabetes mellitus: OHTAC recommendation. Toronto: Health Quality Ontario (HQO). OHTAC Recommendation. 2015 Authors' conclusions OHTAC members acknowledged that there was uncertainty in the evidence that islet transplantation improved secondary complications of diabetes and quality of life. However, OHTAC also recognized that patients being treated with islet transplantation had a very complicated form

2016 Health Technology Assessment (HTA) Database.

112. Patient perspectives on quality of life with cncontrolled type 1 diabetes mellitus: a systematic review and qualitative meta-synthesis

Patient perspectives on quality of life with cncontrolled type 1 diabetes mellitus: a systematic review and qualitative meta-synthesis Patient perspectives on quality of life with controlled type 1 diabetes mellitus: a systematic review and qualitative meta-synthesis Patient perspectives on quality of life with controlled type 1 diabetes mellitus: a systematic review and qualitative meta-synthesis Vanstone M, Rewegan A, Brundisini F, Dejean D, Giacomini M Record Status This is a bibliographic (...) record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Vanstone M, Rewegan A, Brundisini F, Dejean D, Giacomini M. Patient perspectives on quality of life with controlled type 1 diabetes mellitus: a systematic review and qualitative meta-synthesis. Toronto: Health Quality Ontario (HQO). Ontario health technology assessment series. 2015 Authors' conclusions Serious consequences of type 1

2016 Health Technology Assessment (HTA) Database.

113. Statement on prescribing Freestyle Libre flash glucose monitoring system for type 1 and type 2 diabetes

requiring multiple daily insulin dosing for Type 1 and Type 2 diabetes mellitus. The current evidence, however, does not support routine adoption. The use of Freestyle Libre may be considered as an alternative to finger-prick selfmonitoring of blood glucose in clinical circumstances where multiple testing (eight or more times per day) is required. Why was this topic appraised? HTW previously facilitated publication of an Interim Statement on the prescribing of FreeStyle Libre flash glucose monitoring (...) Statement on prescribing Freestyle Libre flash glucose monitoring system for type 1 and type 2 diabetes FreeStyle Libre flash glucose monitoring - Health Technology Wales > FreeStyle Libre flash glucose monitoring FreeStyle Libre flash glucose monitoring Topic Status Incomplete FreeStyle Libre flash glucose monitoring for the management of type 1 or type 2 diabetes. Outcome of the appraisal Freestyle Libre shows promise for detecting and guiding the correction of hypoglycaemia in patients

2018 Health Technology Wales

114. Zinc, copper, and oxysterol levels in patients with type 1 and type 2 diabetes mellitus. (Abstract)

Zinc, copper, and oxysterol levels in patients with type 1 and type 2 diabetes mellitus. The present study has the objective to assess the zinc (Zn), copper (Cu), and oxysterols plasma levels in type 1 (DM1) (n = 26) and type 2 (DM2) (n = 80) diabetes patients, as compared to healthy controls (n = 71), in order to testify whether metal levels may have a significant impact on the association between oxysterols and diabetes.Plasma trace elements and plasma oxysterols were assessed using atomic (...) levels were reported. The 7-ketocholesterol (7-kchol) levels in DM1 and DM2 patients exceeded these values in healthy individuals by 2.5 and 5-fold, respectively. Similarly, cholestan-3β, 5α, 6β-triol (chol-triol) levels were more than 3- and 6-fold higher when compared to the respective values in non-diabetic controls. In regression models decreased plasma Zn and elevated oxysterol levels were significantly associated with HbA1c and fasting plasma glucose levels, after adjustment for anthropometric

2019 Clinical nutrition (Edinburgh, Scotland)

115. Correction to: Randomized trial of an increased dose of calcium channel blocker or angiotensin II type 1 receptor blocker as an add-on intensive depressor therapy in type 2 diabetes mellitus patients with uncontrolled essential hypertension: the ACADEMIE Full Text available with Trip Pro

Correction to: Randomized trial of an increased dose of calcium channel blocker or angiotensin II type 1 receptor blocker as an add-on intensive depressor therapy in type 2 diabetes mellitus patients with uncontrolled essential hypertension: the ACADEMIE In the Original publication of the article, the legend appearing inside the flow chart has been incorrectly published.

2019 Heart and vessels Controlled trial quality: uncertain

116. Increased risk of long-term sickness absence, lower rate of return to work and higher risk of disability pension among people with type 1 and type 2 diabetes mellitus: a Danish retrospective cohort study with up to 17 years' follow-up. (Abstract)

Increased risk of long-term sickness absence, lower rate of return to work and higher risk of disability pension among people with type 1 and type 2 diabetes mellitus: a Danish retrospective cohort study with up to 17 years' follow-up. To evaluate labour market outcomes in type 1 or type 2 diabetes.Individuals with type 1 (n = 431) and type 2 diabetes (n = 4047) were identified in Danish national registers from 1994 to 2011 and compared with individuals without diabetes (n = 101 295). Multi (...) -state Cox proportional hazards analyses estimated hazard ratios (HR) with 95% confidence intervals (CI) for transitions between work, sickness absence, unemployment and disability pension.We observed significantly higher HR of sickness absence in type 1 diabetes (women: 1.34, 95% CI 1.12-1.62; men: 1.43, 1.01-2.03) and type 2 diabetes (women: 1.46, 95% CI 1.35-1.58; men: 1.64, 1.46-1.85) compared with people without diabetes. HR of unemployment was higher for men with type 1 diabetes (1.25, 95% CI

2019 Diabetic Medicine

117. Cost-effectiveness of insulin degludec versus insulin glargine U100 in adults with type 1 and type 2 diabetes mellitus in Bulgaria. Full Text available with Trip Pro

Cost-effectiveness of insulin degludec versus insulin glargine U100 in adults with type 1 and type 2 diabetes mellitus in Bulgaria. This analysis evaluates the cost-effectiveness of insulin degludec (degludec) versus biosimilar insulin glargine U100 (glargine U100) in patients with type 1 (T1DM) and type 2 diabetes mellitus (T2DM) in Bulgaria.A simple, short-term model was used to compare the treatment costs and outcomes associated with hypoglycaemic events with degludec versus glargine U100 (...) in patients with T1DM and T2DM from the perspective of the Bulgarian National Health Insurance Fund. Cost-effectiveness was analysed over a 1-year time horizon using data from clinical trials. The incremental cost-effectiveness ratio (ICER) was the main outcome measure.In Bulgaria, degludec was highly cost-effective versus glargine U100 in people with T1DM and T2DM. The ICERs were estimated to be 4493.68 BGN/quality-adjusted life year (QALY) in T1DM, 399.11 BGN/QALY in T2DM on basal oral therapy (T2DMBOT

2019 BMC Endocrine Disorders

118. Maternal Gestational Diabetes Mellitus, Type 1 Diabetes, and Type 2 Diabetes During Pregnancy and Risk of ADHD in Offspring. Full Text available with Trip Pro

Maternal Gestational Diabetes Mellitus, Type 1 Diabetes, and Type 2 Diabetes During Pregnancy and Risk of ADHD in Offspring. To examine the relative importance of maternal preexisting type 1 diabetes (T1D), preexisting type 2 diabetes (T2D), and gestational diabetes mellitus (GDM) on risk of attention deficit/hyperactivity disorder (ADHD) in offspring.This retrospective birth cohort study included 333,182 singletons born in 1995-2012 within Kaiser Permanente Southern California hospitals (...) . Children were prospectively followed through electronic medical records from age 4 years. Relative risks of ADHD associated with diabetes exposures in utero were estimated by hazard ratios (HRs) using Cox regression with adjustment for potential confounders. For GDM, timing of exposure was evaluated by gestational age at diagnosis and severity was assessed by the need for antidiabetes medication treatment during pregnancy.A total of 37,878 (11.4%) children were exposed to diabetes (522 exposed to T1D

2018 Diabetes Care

119. Sotagliflozin: a dual sodium-glucose co-transporter-1 and -2 inhibitor for the management of Type 1 and Type 2 diabetes mellitus. Full Text available with Trip Pro

Sotagliflozin: a dual sodium-glucose co-transporter-1 and -2 inhibitor for the management of Type 1 and Type 2 diabetes mellitus. To evaluate the evidence for the novel dual sodium-glucose co-transporter-1 (SGLT1) and -2 (SGLT2) inhibitor, sotagliflozin, which may enhance the efficacy of SGLT2 inhibitors by additionally reducing intestinal glucose absorption.The search terms 'sotagliflozin', 'LX4211', 'SGLT' and 'diabetes' were entered into PubMed. Evidence for the pharmacokinetics (...) , pharmacodynamics, safety and efficacy of sotagliflozin in Type 1 and 2 diabetes was extracted from the retrieved literature, critically evaluated, and contextualized in relation to data on existing SGLT2 inhibitors.There is convincing evidence from a range of phase II and III clinical trials that sotagliflozin significantly improves glycaemic control in both Type 1 and Type 2 diabetes. Additional benefits, such as smaller postprandial plasma glucose excursions, lower insulin requirements, appetite suppression

2018 Diabetic Medicine

120. Insulin degludec (Type 1 diabetes mellitus) ? Benefit assessment according to §35a Social Code Book V

Insulin degludec (Type 1 diabetes mellitus) ? Benefit assessment according to §35a Social Code Book V Extract 1 Translation of Assessment module I, Sections I 2.1 to I 2.6, and Assessment module II, Sections II 2.1 to II 2.6, of the dossier assessment Insulin degludec – Nutzenbewertung gemäß § 35a SGB V (Version 1.0; Status: 30 July 2014). Please note: This translation is provided as a service by IQWiG to English-language readers. However, solely the German original text is absolutely (...) Commissioning agency: Federal Joint Committee Commission awarded on: 29 April 2014 Internal Commission No.: A14-13 Address of publisher: Institute for Quality and Efficiency in Health Care Im Mediapark 8 (KölnTurm) 50670 Cologne Germany Tel.: +49 (0)221 – 35685-0 Fax: +49 (0)221 – 35685-1 E-Mail: berichte@iqwig.de Internet: www.iqwig.de Extract of dossier assessment A14-13 – Benefit assessment acc. to §35a SGB V Version 1.0 Insulin degludec – Type 1 diabetes mellitus 30 July 2014 Institute for Quality

2014 Institute for Quality and Efficiency in Healthcare (IQWiG)

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