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Type 1 Diabetes Mellitus

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101. Excess mortality and life expectancy of individuals with type 1 diabetes: a rapid review

: Diabetes Mellitus, Type 1; Life expectancy; Mortality; Survival NLM Classification: WK810 Language: English Format: Adobe® PDF™ (A4) Legal depot: D/2019/10.273/37 ISSN: 2466-6459 Copyright: KCE reports are published under a “by/nc/nd” Creative Commons Licence http://kce.fgov.be/content/about-copyrights-for-kce-publications. How to refer to this document? Louwagie P, De Laet C, Roberfroid D. Excess mortality and life expectancy of individuals with type 1 diabetes: a rapid review. Health Services (...) Research (HSR) Brussels: Belgian Health Care Knowledge Centre (KCE). 2019. KCE Reports 314. D/2019/10.273/37. This document is available on the website of the Belgian Health Care Knowledge Centre. KCE Report 314 Excess mortality and life expectancy of individuals with type 1 diabetes 1 ? TABLE OF CONTENTS LIST OF TABLES 4 LIST OF ABBREVIATIONS 5 ? SCIENTIFIC REPORT 7 1 BACKGROUND 7 1.1. CONTEXT 7 1.2. RESEARCH QUESTION 7 1.3. TYPE 1 DIABETES MELLITUS 7 1.4. GENERAL CLINICAL CONSIDERATIONS AND CONTEXT 8

2019 Belgian Health Care Knowledge Centre

102. Type 1 diabetes

2 diabetes . This CKS topic does not cover the prescribing of insulin or the management of women with type 2 diabetes who are pregnant, planning 2016 2. Dipeptidyl-peptidase (DPP)-4 inhibitors and glucagon-like peptide (GLP)- 1 analogues for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk for the development of type 2 diabetes mellitus . BACKGROUND: The projected rise in the incidence of type 2 diabetes mellitus (T2DM) could develop (...) % up to 3% after surgery, an effect rarely equaled by medical treatment alone. In the SOS study, the remission rate for type 2 diabetes mellitus was 72% at 2 years and 36% at 10 2015 4. Newer Drugs for Type 2 Diabetes : An Emerging Adjunctive Therapy to Insulin for Type 1 Diabetes ? Newer Drugs for Type 2 Diabetes : An Emerging Adjunctive Therapy to Insulin for Type 1 Diabetes ? | CADTH.ca Français Français CADTH Document Viewer Newer Drugs for Type 2 Diabetes : An Emerging Adjunctive Therapy

2018 Trip Latest and Greatest

103. The efficacy of pregabalin for treating pain associated with diabetic peripheral neuropathy in subjects with type 1 or type 2 diabetes mellitus. (Abstract)

The efficacy of pregabalin for treating pain associated with diabetic peripheral neuropathy in subjects with type 1 or type 2 diabetes mellitus. The objective of this study was to compare the efficacy and safety of pregabalin for painful diabetic peripheral neuropathy (pDPN) in subjects with type 1 (T1DM) or 2 diabetes mellitus (T2DM).Pooled data from 10 randomized clinical trials (pregabalin-treated T1DM and T2DM subjects with pDPN) were analyzed for change from baseline (CFB) scores (pain (...) and sleep disturbance) using mixed model repeated measures (MMRM) through Week 12 and last observation carried forward (LOCF). Adverse events (AEs) were recorded.Pregabalin-treated (T1DM 156 [8.7%]; T2DM 1632 [91.3%]) and placebo subjects (T1DM 92 [9.6%]; T2DM 868 [90.4%]) had comparable baseline demographic characteristics between treatment groups within the same diabetes type. T2DM (vs. T1DM) subjects were ∼10 years older. With pregabalin and placebo, respectively, mean ± SD baseline pain (T1DM: 6.2

2018 Current medical research and opinion Controlled trial quality: uncertain

104. QUANTITATIVE AND QUALITATIVE ANALYSIS OF THE THREE CAPILLARY PLEXUSES AND CHORIOCAPILLARIS IN PATIENTS WITH TYPE 1 AND TYPE 2 DIABETES MELLITUS WITHOUT CLINICAL SIGNS OF DIABETIC RETINOPATHY: A Prospective Pilot Study. (Abstract)

QUANTITATIVE AND QUALITATIVE ANALYSIS OF THE THREE CAPILLARY PLEXUSES AND CHORIOCAPILLARIS IN PATIENTS WITH TYPE 1 AND TYPE 2 DIABETES MELLITUS WITHOUT CLINICAL SIGNS OF DIABETIC RETINOPATHY: A Prospective Pilot Study. To separately evaluate the three retinal capillary plexuses and the choriocapillaris in patients with diabetes mellitus (DM) Type 1 and Type 2, without clinical signs of diabetic retinopathy.The study was prospective and cross-sectional. Only patients with age ≤55 years were (...) compared with controls (P = 0.003 and P < 0.001, respectively).Microvascular modifications are present in the three retinal capillary plexuses and the choriocapillaris in both DM Type 1 and DM Type 2 even in the absence of clinical signs of diabetic retinopathy.

2018 Retina

105. SKIP (Supporting Kids with diabetes In Physical activity): Feasibility of a randomised controlled trial of a digital intervention for 9-12 year olds with type 1 diabetes mellitus. Full Text available with Trip Pro

SKIP (Supporting Kids with diabetes In Physical activity): Feasibility of a randomised controlled trial of a digital intervention for 9-12 year olds with type 1 diabetes mellitus. Physical activity and self-monitoring are important for children with type 1 diabetes mellitus (T1DM) but it is unclear whether interventions delivered online are feasible, acceptable to patients and efficacious. The aim was to assess the feasibility and acceptability of an internet-based physical activity and self

2019 BMC Public Health Controlled trial quality: predicted high

106. Testing for type 1 diabetes autoantibodies in gestational diabetes mellitus (GDM): is it clinically useful? Full Text available with Trip Pro

Testing for type 1 diabetes autoantibodies in gestational diabetes mellitus (GDM): is it clinically useful? Gestational Diabetes Mellitus (GDM) is the most common metabolic disorder in pregnancy, and it is associated with increased risk of morbidity in maternal-fetal outcomes. GDM is also associated with a higher risk to develop diabetes in the future. Diabetes-related autoantibodies (AABs) have been detected in a small percentage (usually less than 10%) of women with gestational diabetes (...) . The prevalence in gestational diabetes of these autoimmune markers of type 1 diabetes (T1D) has been assessed in many studies, together with the risk of progression of AABs-positive GDM towards impaired glucose regulation (IFG or IGT) and overt diabetes after pregancy. The question whether it is necessary to test for T1D autoantibodies in all pregnancies with GDM is still debated. Here we examine the epidemiology of T1D autoantibodies in GDM, their clinical relevance in term of future risk of diabetes

2019 BMC Endocrine Disorders

107. Change in peripapillary and macular choroidal thickness change in children with type 1 diabetes mellitus without visual impairment or diabetic retinopathy. (Abstract)

Change in peripapillary and macular choroidal thickness change in children with type 1 diabetes mellitus without visual impairment or diabetic retinopathy. To study the characteristics of choroid thickness (CT) of the optic disc and macula in children with type 1 diabetes mellitus (T1DM) without visual impairment and diabetic retinopathy (DR) and analyse associated factors.A square area of 6 × 6 mm around the centre of the optic disc and macula was scanned. The indices analysed mainly included (...) CT at the macular centre (1 mm), and temporal, superior, nasal or inferior aspect of the inner ring (1-3 mm) and outer ring of (3-6 mm) optic disc and macula. Independent risk factors were analysed using multifactor linear regression.A total of 44 children with T1DM and 48 healthy subjects were enrolled. The diabetic group showed significant increase in the inferior inner ring of parapapillary CT (100.99 ± 30.42 μm versus 89.41 ± 34.00 μm, p = 0.04) and nasal outer ring of parapapillary CT

2019 Acta ophthalmologica

108. Copeptin and insulin-like growth factor binding protein-1 during follow-up after an acute myocardial infarction in patients with type 2 diabetes: A report from the Diabetes Mellitus Insulin-Glucose Infusion in Acute Myocardial Infarction 2 cohort. Full Text available with Trip Pro

Copeptin and insulin-like growth factor binding protein-1 during follow-up after an acute myocardial infarction in patients with type 2 diabetes: A report from the Diabetes Mellitus Insulin-Glucose Infusion in Acute Myocardial Infarction 2 cohort. Copeptin and insulin-like growth factor binding protein-1 analysed at admission for a myocardial infarction in patients with type 2 diabetes mellitus predicts cardiovascular events. The present aim was to study the association between copeptin (...) and insulin-like growth factor binding protein-1, the development of the levels over time, and if the predictive value remained when measured at hospital discharge and 3 months thereafter.Copeptin and insulin-like growth factor binding protein-1 were analysed in patients (median age = 70, male = 68%) with type 2 diabetes mellitus + myocardial infarction at admission (n = 393), discharge (n = 309) and 3 months later (n = 288). The primary endpoint was cardiovascular event (cardiovascular death/non-fatal

2019 Diabetes & Vascular Disease Research Controlled trial quality: uncertain

109. Retinal Microvascular Abnormalities in Children with Type 1 Diabetes Mellitus Without Visual Impairment or Diabetic Retinopathy. Full Text available with Trip Pro

Retinal Microvascular Abnormalities in Children with Type 1 Diabetes Mellitus Without Visual Impairment or Diabetic Retinopathy. To study the characteristics and associated factors of retinal microvascular abnormalities in children with type 1 diabetes mellitus (T1DM) without visual impairment and diabetic retinopathy (DR).Case-control hospital-based study including children with or without DM. Optical coherence tomography angiography (OCTA; CIRRUS HD-OCT model 5000) was used to scan 6 × 6 mm (...) square area of posterior retina and optic disc. The indexes analyzed mainly included vascular length density (VD), perfusion density (PD), and foveal avascular zone area, perimeter, and morphology. Independent risk factors were analyzed by multifactor linear regression.A total of 47 children with T1DM and 44 healthy subjects were enrolled. Statistical analysis showed that VD within 1 to 3 mm (inner ring) of the macula in the case group was smaller than that in the control group (18.561 ± 1.151/mm

2019 Investigative Ophthalmology & Visual Science

110. Prevalence and characteristics of celiac disease in South African patients with type 1 diabetes mellitus: Results from the Durban Diabetes and Celiac Disease Study. (Abstract)

Prevalence and characteristics of celiac disease in South African patients with type 1 diabetes mellitus: Results from the Durban Diabetes and Celiac Disease Study. The aim of this study was to assess the prevalence and characteristics of celiac disease (CD) in all patients with type 1 diabetes mellitus attending a tertiary adult diabetes clinic in Durban, South Africa.This was a cross-sectional observational study that screened 202 patients; of these, 56.4% were African (Black), 31.7% Asian (...) from western countries. No ethnic specific differences were noted. CD was silent in all patients in this study. The sensitivity of EMA and tTG antibodies was poor and merits further evaluation as screening tools for CD in South African patients with type 1 diabetes mellitus.© 2019 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.

2019 Journal of gastroenterology and hepatology

111. Changes in Retinal Microcirculation Precede the Clinical Onset of Diabetic Retinopathy in Children with Type 1 Diabetes Mellitus. (Abstract)

Changes in Retinal Microcirculation Precede the Clinical Onset of Diabetic Retinopathy in Children with Type 1 Diabetes Mellitus. To investigate whether abnormal glucose metabolism in diabetes mellitus (DM) affects the retinal microcirculation of children with well-controlled type 1 DM and to compare these results with those obtained from healthy children.Cross-sectional prospective study.This study enrolled 60 patients with DM without clinically detectable diabetic retinopathy (DR) and who met (...) and glycated hemoglobin (HbA1c) levels were evaluated among patients with type 1 DM.Differences in the mean values for FAZ perimeter, AI, and FD-300 were statistically significant between DM group and control group (P<0.001, P=0.001 and P=0.009, respectively). There were also statistically significant differences between the groups for vessel densities of deep superior hemi-parafovea, deep temporal parafovea, and deep superior parafoveal zones (P=0.008, P=0.015 and P=0.005, respectively). There were

2019 American Journal of Ophthalmology

112. Diabetes (type 1 and type 2) in children and young people: diagnosis and management

with type 1 diabetes multiple daily injection basal–bolus insulin regimens from diagnosis. If a multiple daily injection regimen is not appropriate for a child or young person with type 1 diabetes, consider continuous subcutaneous insulin infusion (CSII or insulin pump) therapy as recommended in continuous subcutaneous insulin infusion for the treatment of diabetes mellitus (NICE technology appraisal guidance 151). [new 2015] [new 2015] Dietary management for children and young people with type 1 (...) ://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 12 of 85diagnosis and classification of diabetes mellitus. [2004, amended 2015] [2004, amended 2015] 1.1.4 When diagnosing diabetes in a child or young person, assume type 1 diabetes unless there are strong indications of type 2 diabetes, monogenic or mitochondrial diabetes (see recommendations 1.1.5 and 1.1.6). [new 2015] [new 2015] 1.1.5 Think about the possibility of type 2 diabetes in children and young people with suspected diabetes who: have

2015 National Institute for Health and Clinical Excellence - Clinical Guidelines

113. Multi-informant path models of the influence of psychosocial and treatment-related variables on adherence and metabolic control in adolescents with type 1 diabetes mellitus. Full Text available with Trip Pro

Multi-informant path models of the influence of psychosocial and treatment-related variables on adherence and metabolic control in adolescents with type 1 diabetes mellitus. We assessed the associations between metabolic control and adherence and a broad range of adolescent and family characteristics (e.g., gender, family structure), treatment-related variables (e.g., disease duration, treatment modality), and psychosocial factors (e.g., symptoms of depression and anxiety, parental support (...) , self-efficacy) in a nationwide study of Danish adolescents (age 12-17 years) with type 1 diabetes mellitus (T1DM).Sixty-four percent of invited families participated by completing a survey and providing a blood sample. Two path models of associations between generic and diabetes-related family factors, adolescent self-efficacy, emotional difficulties, and metabolic control and adherence were tested, one for adolescents and one for caregivers. Demographic variables were included as covariates.Both

2018 PLoS ONE

114. Heterogeneity of circulating CD8 T-cells specific to islet, neo-antigen and virus in patients with type 1 diabetes mellitus. Full Text available with Trip Pro

Heterogeneity of circulating CD8 T-cells specific to islet, neo-antigen and virus in patients with type 1 diabetes mellitus. Auto-reactive CD8 T-cells play an important role in the destruction of pancreatic β-cells resulting in type 1 diabetes (T1D). However, the phenotype of these auto-reactive cytolytic CD8 T-cells has not yet been extensively described. We used high-dimensional mass cytometry to phenotype autoantigen- (pre-proinsulin), neoantigen- (insulin-DRIP) and virus- (cytomegalovirus

2018 PLoS ONE

115. Sociodemographic determinants and health outcome variation in individuals with type 1 diabetes mellitus: A register-based study. Full Text available with Trip Pro

Sociodemographic determinants and health outcome variation in individuals with type 1 diabetes mellitus: A register-based study. Socioeconomic status, origin or demographic attributes shall not determine the quality of healthcare delivery, according to e.g. United Nations and European Union rules. Health equity has been defined as the absence of systematic disparities and unwarranted differences between groups defined by differences in social advantages. A study was performed to investigate (...) whether this was applicable to type 1 diabetes mellitus (T1D) care in a setting with universal, tax-funded healthcare.This retrospective registry-study was based on patient-level data from individuals diagnosed with T1D during 2010-2011 (n = 16,367) in any of seven Swedish county councils (covering ~65% of the Swedish population). Health equity in T1D care was analysed through multivariate regression analyses on absolute HbA1c level at one-year follow-up, one-year change in estimated glomerular

2018 PLoS ONE

116. Influence of hyperbaric oxygen on biomechanics and structural bone matrix in type 1 diabetes mellitus rats. Full Text available with Trip Pro

Influence of hyperbaric oxygen on biomechanics and structural bone matrix in type 1 diabetes mellitus rats. The aim of this study was to evaluate the biomechanics and structural bone matrix in diabetic rats subjected to hyperbaric oxygen therapy (HBO).Twenty-four male rats were divided into the following groups: Control; Control + HBO; Diabetic, and Diabetic + HBO. Diabetes was induced with streptozotocin (STZ) in the diabetic Groups. After 30 days, HBO was performed every 48h in HBO groups (...) and all animals were euthanized 60 days after diabetic induction. The femur was submitted to a biomechanical (maximum strength, energy-to-failure and stiffness) and Attenuated Total Reflectance Fourier transform infrared (ATR-FTIR) analyses (crosslink ratio, crystallinity index, matrix-to-mineral ratio: Amide I + II/Hydroxyapatite (M:MI) and Amide III + Collagen/HA (M:MIII)).In biomechanical analysis, diabetic animals showed lower values of maximum strength, energy and stiffness than non-diabetic

2018 PLoS ONE

117. Comparison of proinsulin and C-peptide secretion in healthy versus long-standing type 1 diabetes mellitus cohorts: A pilot study. Full Text available with Trip Pro

Comparison of proinsulin and C-peptide secretion in healthy versus long-standing type 1 diabetes mellitus cohorts: A pilot study. Increased proinsulin (PI) compared to C-peptide (CP) concentrations have been reported, both prior to type 1 diabetes mellitus (T1D) onset, as well as early in disease. In this pilot study, we sought to define the normal PI secretion in a healthy cohort and compare this to a local T1D cohort and a separate well-defined nationally representative T1D cohort

2018 PLoS ONE

118. Programmed cell death-1 (PD-1) inhibitor induced type 1 diabetes mellitus: mini-review. Full Text available with Trip Pro

Programmed cell death-1 (PD-1) inhibitor induced type 1 diabetes mellitus: mini-review. Pembrolizumab (Keytruda; Merck Sharp & Dohme) is a humanized IgG4 monoclonal antibody used in cancer immunotherapy. It targets the programmed cell death-1 (PD-1) receptor, which is important in maintaining self-tolerance. However, immune checkpoint blockade is associated with a risk for immune-related adverse events (irAEs) potentially affecting the endocrine organs. Type 1 diabetes mellitus is a rare irAE (...) (n = 42) of PD-1 inhibitor-induced type 1 diabetes mellitus to date, including a well-characterized case of islet cell antibody and glutamic acid decarboxylase antibody-positive diabetes mellitus, in a patient with a diabetes-prone HLA genotype. She presented with diabetic ketoacidosis during pembrolizumab therapy for a metastatic uveal melanoma. Furthermore, we discuss potential pathogenic mechanisms, clinical presentation, prognostic markers (β-cell antibodies and HLA type), treatment

2018 Journal of Clinical Endocrinology and Metabolism

119. A Variation in the ABCC8 Gene Is Associated with Type 2 Diabetes Mellitus and Repaglinide Efficacy in Chinese Type 2 Diabetes Mellitus Patients. Full Text available with Trip Pro

the associations of the ABCC8 rs1801261 polymorphism with type 2 diabetes mellitus (T2DM) susceptibility and repaglinide therapeutic efficacy in Chinese Han T2DM patients. Methods A total of 234 T2DM patients and 105 healthy subjects were genotyped for ABCC8 rs1801261 polymorphism by a polymerase chain reaction-restriction fragment length polymorphism assay. A total of 70 patients with the same genotypes of CYP2C8*3 139Arg and OATP1B1 521TT were randomized to orally take 3 mg repaglinide per day (1 mg each time (...) A Variation in the ABCC8 Gene Is Associated with Type 2 Diabetes Mellitus and Repaglinide Efficacy in Chinese Type 2 Diabetes Mellitus Patients. Objective Previous studies have suggested that variations in the ABCC8 gene may be closely associated with T2DM susceptibility and repaglinide response. However, these results have not been entirely consistent, and there are no related studies in a Chinese population, suggesting the need for further exploration. The current study investigated

2019 Internal medicine (Tokyo, Japan) Controlled trial quality: uncertain

120. Type 2 diabetes mellitus in adults: high-strength insulin glargine 300 units/ml (Toujeo)

for once-daily use for the treatment of diabetes mellitus (type 1 and type 2) in adults. In people with type 2 diabetes, it can be given together with other anti-hyperglycaemic medicinal products. T oujeo is not bioequivalent to insulin glargine 100 units/ml (Lantus) and dose adjustment is needed when patients are switched from Lantus or other basal insulins to T oujeo or vice versa (MHRA Drug Safety Update April 2015). T oujeo has a flatter and more prolonged (up to 36 hours) profile of insulin (...) on its pharmacodynamic and pharmacokinetic profiles, is associated with a lower risk of hypoglycaemia. The main phase 3 study of T oujeo in adults with type 1 diabetes (EDITION 4) is reviewed in the evidence summary on type 1 diabetes. In EDITION 1 (n=807), EDITION 2 (n=811) and EDITION 3 (n=878), once-daily insulin glargine 300 units/ml (T oujeo) was non-inferior to once-daily insulin glargine 100 units/ml (Lantus) in Type 2 diabetes mellitus in adults: high-strength insulin glargine 300 units/ml

2015 National Institute for Health and Clinical Excellence - Advice

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