How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

113,131 results for

Treating Family Members

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

141. Burosumab for treating X-linked hypophosphataemia in children and young people

Evaluation committee members 29 NICE project team 29 Burosumab for treating X-linked hypophosphataemia in children and young people (HST8) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 3 of 301 1 Recommendations Recommendations 1.1 Burosumab is recommended, within its marketing authorisation, for treating X-linked hypophosphataemia (XLH) with radiographic evidence of bone disease in children aged 1 year and over (...) to errors in phosphate sensing and increased levels of fibroblast growth factor 23 (FGF23). Excess FGF23 causes impaired phosphate conservation and excessive phosphate excretion. It also supresses vitamin D production, which causes reduced calcium and phosphate absorption. 2.2 Because XLH is a genetic condition, it often affects several members of a family. Skeletal abnormalities such as bowed or bent legs, below average height and irregular growth of the skull are early signs of XLH. Children may also

2018 National Institute for Health and Clinical Excellence - Highly specialised technology

142. Pertuzumab with trastuzumab and docetaxel for treating HER2-positive breast cancer

-of-rights). Page 2 of 18Contents Contents 1 Recommendations 4 2 The technology 5 3 Evidence 6 4 Committee discussion 7 Clinical effectiveness 9 Cost effectiveness 10 Innovation 12 End-of-life considerations 13 Conclusions 14 5 Implementation 16 6 Appraisal committee members and NICE project team 17 Appraisal committee members 17 NICE project team 17 Pertuzumab with trastuzumab and docetaxel for treating HER2-positive breast cancer (TA509) © NICE 2018. All rights reserved. Subject to Notice of rights (...) enquiries from NHS organisations about the commercial access agreement should be directed to global.pas@roche.com. Pertuzumab with trastuzumab and docetaxel for treating HER2-positive breast cancer (TA509) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 16 of 186 6 Appr Appraisal committee members and NICE project team aisal committee members and NICE project team Appraisal committee members The technology appraisal

2018 National Institute for Health and Clinical Excellence - Technology Appraisals

143. Daratumumab monotherapy for treating relapsed and refractory multiple myeloma

of 31Contents Contents 1 Recommendations 4 2 Information about daratumumab 5 3 Evidence 6 4 Committee discussion 7 Nature of the condition 7 Clinical pathway 7 Clinical effectiveness 8 Cost effectiveness 16 Innovation 20 End-of-life considerations 21 Cancer Drugs Fund considerations 21 Summary of appraisal committee's key conclusions 24 5 Implementation 29 6 Appraisal committee members and NICE project team 30 Appraisal committee members 30 NICE project team 30 Daratumumab monotherapy for treating relapsed (...) Daratumumab monotherapy for treating relapsed and refractory multiple myeloma Dar Daratumumab monother atumumab monotherap apy for treating y for treating relapsed and refr relapsed and refractory multiple actory multiple m my yeloma eloma T echnology appraisal guidance Published: 14 March 2018 nice.org.uk/guidance/ta510 © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility

2018 National Institute for Health and Clinical Excellence - Technology Appraisals

144. Ixazomib with lenalidomide and dexamethasone for treating relapsed or refractory multiple myeloma

for data collection 19 6 Appraisal committee members and NICE project team 20 Appraisal committee members 20 NICE project team 20 Ixazomib with lenalidomide and dexamethasone for treating relapsed or refractory multiple myeloma (TA505) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 3 of 211 1 Recommendations Recommendations 1.1 Ixazomib, with lenalidomide and dexamethasone, is recommended for use within the Cancer (...) -1 clinical trial. Data on overall survival and time-on- treatment will be collected through other sources including the Systemic Anti- Cancer Therapy (SACT) dataset. Ixazomib with lenalidomide and dexamethasone for treating relapsed or refractory multiple myeloma (TA505) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 19 of 216 6 Appr Appraisal committee members and NICE project team aisal committee members

2018 National Institute for Health and Clinical Excellence - Technology Appraisals

145. Ibrutinib for treating relapsed or refractory mantle cell lymphoma

3 Evidence 6 4 Committee discussion 7 Clinical effectiveness 7 Cost effectiveness 11 End-of-life considerations 13 Potential equality issues 14 Pharmaceutical Price Regulation Scheme (PPRS) 2014 14 Summary of appraisal committee's key conclusions 14 5 Implementation 20 6 Appraisal committee members and NICE project team 21 Appraisal committee members 21 NICE project team 21 Ibrutinib for treating relapsed or refractory mantle cell lymphoma (TA502) © NICE 2018. All rights reserved. Subject (...) Ibrutinib for treating relapsed or refractory mantle cell lymphoma Ibrutinib for treating relapsed or Ibrutinib for treating relapsed or refr refractory mantle cell lymphoma actory mantle cell lymphoma T echnology appraisal guidance Published: 31 January 2018 nice.org.uk/guidance/ta502 © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility The recommendations in this guidance

2018 National Institute for Health and Clinical Excellence - Technology Appraisals

146. Pirfenidone for treating idiopathic pulmonary fibrosis

discussion 7 Review objectives 7 Current practice 7 Comparators 8 Clinical effectiveness 8 Cost effectiveness 11 Cost-effectiveness results and conclusions 16 Potential equality issues 18 The Pharmaceutical Price Regulation Scheme 19 Summary of appraisal committee's key conclusions 19 5 Implementation 24 6 Appraisal committee members, guideline representatives and NICE project team 25 Appraisal committee members 25 NICE project team 25 Pirfenidone for treating idiopathic pulmonary fibrosis (TA504) © NICE (...) Pirfenidone for treating idiopathic pulmonary fibrosis Pirfenidone for treating idiopathic Pirfenidone for treating idiopathic pulmonary fibrosis pulmonary fibrosis T echnology appraisal guidance Published: 6 February 2018 nice.org.uk/guidance/ta504 © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility The recommendations in this guidance represent the view of NICE, arrived

2018 National Institute for Health and Clinical Excellence - Technology Appraisals

147. Novel <i>MYOC</i> gene mutation in a Chinese family with primary open-angle glaucoma. (PubMed)

in combination with high-throughput sequencing and validated using Sanger sequencing. Phenotypic characterisation included investigation into patient medical history and physical examination.Eight (36.4%) family members harboured heterozygous Y437H mutation, of whom seven (87.5%) were glaucomatous and one (12.5%) had OHT. The mean age of POAG diagnosis was 30.85±7.13 years. The mean highest recorded intraocular pressure (IOP) was 46.57±6.53 mm Hg. They all had complained of symptoms associated with vision (...) Novel MYOC gene mutation in a Chinese family with primary open-angle glaucoma. To characterise the genotype(s), phenotype(s) and age-related penetrance of glaucoma in a Chinese family with primary open-angle glaucoma (POAG).Recruited from a Chinese family spanning four generations, 7 individuals with POAG, 1 with ocular hypertension (OHT) and 14 unaffected individuals were included in this study. Genotypic investigation included sequencing of mutation sites using a glaucoma panel

2019 British Journal of Ophthalmology

148. Contributions of Public Health in Reducing the Population Burden of Familial Hypercholesterolemia: Challenges and Opportunities

surveillance data may include morbidity and mortality associated with FH, as well as FH awareness among patients, family members, and providers Challenge: Absence of population-based surveillance systems and registries (like cancer) Opportunity: Registry and other sources of data can be expanded to provide population level information on FH Challenge: Absence of an FH surveillance “case definition” that can be used for tracking population health burden, and trends over time and in population subgroups (...) Contributions of Public Health in Reducing the Population Burden of Familial Hypercholesterolemia: Challenges and Opportunities Contributions of Public Health in Reducing the Population Burden of Familial Hypercholesterolemia: Challenges and Opportunities | | Blogs | CDC Search Form Controls TOPIC ONLY Search The CDC cancel submit Search Form Controls TOPIC ONLY Search The CDC cancel submit Note: Javascript is disabled or is not supported by your browser. For this reason, some items

2018 CDC Genomics and Health Impact Blog

149. Family-led rehabilitation after stroke in India (ATTEND): a randomised controlled trial. (Full text)

Family-led rehabilitation after stroke in India (ATTEND): a randomised controlled trial. Most people with stroke in India have no access to organised rehabilitation services. The effectiveness of training family members to provide stroke rehabilitation is uncertain. Our primary objective was to determine whether family-led stroke rehabilitation, initiated in hospital and continued at home, would be superior to usual care in a low-resource setting.The Family-led Rehabilitation after Stroke (...) in India (ATTEND) trial was a prospectively randomised open trial with blinded endpoint done across 14 hospitals in India. Patients aged 18 years or older who had had a stroke within the past month, had residual disability and reasonable expectation of survival, and who had an informal family-nominated caregiver were randomly assigned to intervention or usual care by site coordinators using a secure web-based system with minimisation by site and stroke severity. The family members of participants

2017 Lancet PubMed

150. "She Had a Smile on Her Face as Wide as the Great Australian Bite": A Qualitative Examination of Family Perceptions of a Therapeutic Robot and a Plush Toy. (Full text)

"She Had a Smile on Her Face as Wide as the Great Australian Bite": A Qualitative Examination of Family Perceptions of a Therapeutic Robot and a Plush Toy. Recent years have seen social robotic pets introduced as a means of treating behavioral and psychological symptoms of dementia, and many show promising potential. In this study, we sought to explore family members' perceptions of the Japanese-developed baby harp seal, Paro (version 9), and a look-alike, nonrobotic Plush Toy, when used (...) by their relative with dementia for 15 min, 3 afternoons per week for 10 weeks.The study employed a descriptive qualitative approach, which was nested within a larger cluster randomized controlled trial. A convenience sample of 20 family members (n = 10 each from the Paro and Plush Toy conditions) with relatives in 9 long-term care facilities in Queensland, Australia, completed individual semi-structured interviews (telephone or face-to-face). Inductive, data-driven thematic analysis of the data was undertaken

2019 The Gerontologist PubMed

151. Novel SCN2A mutation in a family associated with juvenile-onset myoclonus: Case report. (PubMed)

Novel SCN2A mutation in a family associated with juvenile-onset myoclonus: Case report. The phenotypic spectrum caused by SCN2A mutations includes benign neonatal/infantile seizures, Ohtahara syndrome, infantile spasms, West syndrome, and other unclassified epileptic phenotypes. Mutations in SCN2A have been implicated in neonatal seizure cases. Here, we described a Chinese family with 2 members having juvenile-onset myoclonus and identified a novel SCN2A point mutation within this family.The 21 (...) analyses.Genetic testing revealed a novel SCN2A variant, c.T4820C, which contains a highly conserved amino acid substitution within segment S5 (p.V1607A). This mutation was predicted to produce a dysfunctional Nav1.2 protein by Mutation Taster and Protein Variation Effect Analyzer (PROVEAN). Genotype-phenotype correlation showed an incomplete penetrance of p.V1607A.The proband was treated by multiple antiepileptic drugs. These included carbamazepine, oxcarbazepine, valproate, and topiramate.The duration

2019 Medicine

152. A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family. (Full text)

, we demonstrated that pre-treating hPSCs with dimethylsulfoxide (DMSO) before directed differentiation enhanced differentiation potential across all three germ layers. Here, we show that exposure to DMSO improves the efficiency of hPSC differentiation through Rb and by repressing downstream E2F-target genes. While transient inactivation of the Rb family members (including Rb, p107, and p130) suppresses DMSO's capacity to enhance differentiation across all germ layers, transient expression (...) A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family. The propensity for differentiation varies substantially across human pluripotent stem cell (hPSC) lines, greatly restricting the use of hPSCs for cell replacement therapy or disease modeling. Here, we investigate the underlying mechanisms and demonstrate that activation of the retinoblastoma (Rb) pathway in a transient manner is important for differentiation. In prior work

2018 PLoS ONE PubMed

153. Assessing health impacts of home food gardens with Wind River Indian Reservation families: protocol for a randomised controlled trial. (Full text)

after 2 years of data collection). Willing family members aged 5 and up will participate in data collection each February and August for 2 years, with blood, biometric and survey measures at each. The primary outcome is adult body mass index (BMI). Secondary outcomes include child BMI, and adult hand strength, self-reported physical and mental health, diabetes control and food security. Primary analysis will be intention to treat (ITT), using univariate and bivariate descriptive statistics followed (...) Assessing health impacts of home food gardens with Wind River Indian Reservation families: protocol for a randomised controlled trial. This community-based participatory research, Growing Resilience, will be the first full-scale randomised controlled trial we have identified that is designed to evaluate impacts of home gardening on family health. It is based on observational studies suggesting home food gardening has myriad health benefits, Wind River Indian Reservation (WRIR) families

2019 BMJ open PubMed

154. Does pain, psychological distress and deteriorated family economy follow traumatic amputation among war casualties? A retrospective, cross-sectional study from Gaza. (Full text)

status, loss of family members and loss of home as independent variables.The amputees median age was 23 years at the time of trauma, while a median of 4.3 years had passed from trauma to study inclusion. Nine of 10 were male, while 43 were children when they were amputated (17%≤18 years). One hundred and ninety-one (75%) were unemployed and 112 (44%) reported unemployment caused by being amputated. Pain was the most frequent problem, and 80 amputees (32%) reported to suffer from daily pain. Family (...) Does pain, psychological distress and deteriorated family economy follow traumatic amputation among war casualties? A retrospective, cross-sectional study from Gaza. The aim of this study was to explore determinants of psychosocial distress and pain in patients who have survived severe extremity amputation in Gaza.This study was conducted in a secondary care rehabilitation centre in Gaza, Palestine. The clinic is Gaza's sole provider of artificial limbs.We included 254 civilian Palestinians who

2019 BMJ open PubMed

155. A family-based multimedia intervention to enhance the uptake of colorectal cancer screening among older South Asian adults in Hong Kong: a study protocol for a cluster randomized controlled trial. (PubMed)

will be carried out. Three hundred and twenty South Asian dyads, comprising an older adult aged between 50 and 75 and a younger family member aged between 18 and 49, will be recruited in ten districts in Hong Kong through community organizations that provide support services for South Asians in local communities. Dyads will be randomly allocated to either the intervention or wait-list control group. Intervention dyads will receive intervention, whose contents are based on the health belief model, via multiple (...) forms of media including PowerPoint presentation, video clip and health information booklet. Control dyads will receive intervention after post-intervention data are collected. For dyads in both groups, an appointment with a family doctor will be arranged for those willing to undergo FOBT. Outcomes will be assessed at baseline and post-intervention. Data will be analysed using the Generalised Linear Models Procedure in an intention-to-treat manner.Findings of this study will provide evidence

2019 BMC Public Health

156. Experiences of how services supporting women with perinatal mental health difficulties work with their families: a qualitative study in England. (PubMed)

Experiences of how services supporting women with perinatal mental health difficulties work with their families: a qualitative study in England. Partners and wider family members play a vital role in relation to women's perinatal mental health. Clinical guidelines in the UK and internationally recommend that services supporting women with perinatal mental health difficulties involve and support their families too. However, little is known about family members' needs and experiences, or whether (...) they feel included by mental health services. This study set out to explore this.This research formed part of a wider study exploring experiences of perinatal mental health care in England. The broader study included semi-structured interviews with 52 women across England who received treatment for a perinatal mental health difficulty, and 32 family members identified by the women as offering them some support. Data from these 84 interviews relating to how services work with partners and families were

2019 BMJ open

157. Dignity of the patient--family unit: further understanding in hospice palliative care. (PubMed)

patient dignity. Themes solely constituting family dignity included being included in care, being capable and being treated fairly. Cultural considerations, environmental factors, teamwork and patient/family-staff relationship were the factors identified by staff members that affected dignity in hospice palliative care.Findings of this study provide insights into the development of strategies to support the dignity of the patient-family unit in hospice palliative care.© Author(s) (or their employer(s (...) Dignity of the patient--family unit: further understanding in hospice palliative care. This study aimed to explore the construct of dignity of the patient-family dyad in hospice palliative care, as well as its influencing factors from the perspective of hospice palliative care staff.A qualitative descriptive study was conducted with 34 staff members from a residential hospice in Amherst, USA, and an inpatient palliative care unit in Winnipeg, Canada, between September 2013 and December 2016

2019 BMJ Supportive & Palliative Care

158. Surgeon Communication and Family Understanding of Patient Prognosis in Critically Ill Surgical Patients: A Qualitative Investigation Informs Resident Training. (PubMed)

Surgeon Communication and Family Understanding of Patient Prognosis in Critically Ill Surgical Patients: A Qualitative Investigation Informs Resident Training. Surgeons treating critically ill patients must work with family members making medical decisions for the patient. These surrogate decision makers depend on providers' high-quality communication and empathy to facilitate medical decisions. There is growing evidence of poor quality of communication and delayed family engagement (...) program to address identified performance gaps.Level I TICU in an independent academic medical center.A qualitative research approach was valuable to discern the complexities of family understanding during highly stressful conditions. We enrolled adult family members of TICU patients, life expectancy <1 year, per attending. Using in-depth interviews we explored the family's experience with providers and the hospital system, and factors influencing understanding of the patient condition and decision

2019 Journal of Surgical Education

159. Family Perceptions of Quality of End-of-Life Care for Veterans with Advanced CKD. (PubMed)

and 2015. We used logistic regression to evaluate associations between patterns of end-of-life care and receipt of dialysis (no dialysis, acute dialysis, maintenance dialysis) with family-reported quality of end-of-life care.Overall, 52% of cohort members spent ≥2 weeks in the hospital in the last 90 days of life, 34% received an intensive procedure, and 47% were admitted to the intensive care unit, in the last 30 days, 31% died in the intensive care unit, 38% received a palliative care consultation (...) Family Perceptions of Quality of End-of-Life Care for Veterans with Advanced CKD. Little is known about the quality of end-of-life care for patients with advanced CKD. We describe the relationship between patterns of end-of-life care and dialysis treatment with family-reported quality of end-of-life care in this population.We designed a retrospective observational study among a national cohort of 9993 veterans with advanced CKD who died in Department of Veterans Affairs facilities between 2009

2019 Clinical Journal of the American Society of Nephrology

160. Soluble concentrations of the interleukin receptor family member ST2 and β-blocker therapy in chronic heart failure. (Full text)

Soluble concentrations of the interleukin receptor family member ST2 and β-blocker therapy in chronic heart failure. Concentrations of soluble (s)ST2 predict prognosis in heart failure. We recently found changing doses of β-blocker (BB) may affect sST2 concentrations. It remains unclear whether sST2 concentrations identify benefit of BB therapy, however.A total of 151 subjects with heart failure attributable to left ventricular systolic dysfunction were examined in this post hoc analysis; >96 (...) sST2/high-dose BB had intermediate outcomes (0.92 and 1.19 events). Patients with high sST2 treated with low-dose BB had the highest cardiovascular event rate (2.08 events) and the highest cumulative hazard. Compared with low sST2/high-dose BB, those with high sST2 treated with low-dose BB had an odds ratio of 6.77 (P<0.001) for a cardiovascular event. Patients with low sST2/low-dose BB or high sST2/high-dose BB had intermediate odds ratios for cardiovascular events (P=0.18 and 0.02). Similar

2013 Circulation. Heart failure PubMed

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>