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Treating Family Members

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113121. The pro-apoptotic Bcl-2 family member tBid localizes to mitochondrial contact sites (PubMed)

The pro-apoptotic Bcl-2 family member tBid localizes to mitochondrial contact sites Following cleavage by caspase 8, the C-terminus of Bid translocates from the cytosol to the mitochondria that is dependent upon structures formed by the mitochondrial-specific lipid cardiolipin. Once associated with mitochondria, truncated Bid (tBid) causes the potent release of cytochrome c, endonuclease G, and smac.We investigated whether tBid localizes specifically to the contact sites of mitochondria (...) as a new hybrid technique to investigate the three-dimensional distributions of tBid and tBidG94E around the mitochondrial periphery. The statistics of spatial point patterns was used to analyze the association of these proteins with contact sites.Immunoelectron tomography with statistical analysis confirmed the preferential association of tBid with mitochondrial contact sites. These findings link these sites with cardiolipin in tBid targeting and suggest a role for Bcl-2 family members in regulating

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2001 BMC Cell Biology

113122. Tissue-specific regulation of the expression of rat kallikrein gene family members by thyroid hormone. (PubMed)

Tissue-specific regulation of the expression of rat kallikrein gene family members by thyroid hormone. We have altered the thyroid hormonal status of both male and female rats and examined the expression of six functional members of the rat kallikrein gene family (PS, S1, S2, S3, K1 and P1) in the submandibular gland (SMG), kidney, prostate, testis and anterior pituitary gland (AP) of these animals. On Northern-blot analysis with gene-specific oligonucleotide probes, the steady-state mRNA (...) in the male or female SMG or kidney were essentially unchanged. K1 mRNA levels in the kidney were considerably less responsive to thyroid status than those in the SMG. Changes in S3 and P1 mRNA levels in the prostate were also variable, but essentially unaffected by these treatments. AP PS mRNA levels were also unaffected by changes in thyroid-hormonal status, as were levels of a novel P1-like mRNA in the testis. In summary, these studies demonstrate that the same kallikrein gene family member(s) may

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1990 Biochemical Journal

113123. Like a Member of the Family: Personal benefits of the physician-patient relationship (PubMed)

Like a Member of the Family: Personal benefits of the physician-patient relationship Some people see family doctors as merely triage physicians without much depth or personal satisfaction in their work. My own experience as a family physician contrasts greatly with this impression. In addition to the satisfaction of treating medical problems, I have seen a significant effect on my own life of the bond with certain of my patients. This paper presents three examples of these special relationships (...) and how they have made family practice particularly rewarding for me.

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1990 Canadian Family Physician

113124. Neutrophil actin dysfunction is a genetic disorder associated with partial impairment of neutrophil actin assembly in three family members. (PubMed)

of detergent insoluble cytoskeletons after stimulation with FMLP was also significantly lower in PMN from NAD family members as compared with controls (21 +/- 6% vs. 73 +/- 8%). PMN extracts from the father and mother, when treated with 0.6 M KCl, polymerized half as much actin as controls. Whereas diisopropylfluorophosphate treatment of normal PMN decreased actin polymerizability in cell extracts, this treatment increased the assembly of actin in parental PMN extract. Addition of purified actin to NAD (...) Neutrophil actin dysfunction is a genetic disorder associated with partial impairment of neutrophil actin assembly in three family members. A male infant with a severe neutrophil motility disorder and poorly polymerizable actin in PMN extracts was reported over a decade ago to have neutrophil actin dysfunction (NAD) (1974. N. Engl. J. Med. 291:1093-1099). Polymerized actin (F-actin) content of fixed and permeabilized intact neutrophils from the father, mother, and sister of the NAD index case

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1988 Journal of Clinical Investigation

113125. Positive Surgical Margins Rate and EGFR Family Members Expression in Prostate Cancer Treated With Bicalutamide

Positive Surgical Margins Rate and EGFR Family Members Expression in Prostate Cancer Treated With Bicalutamide Positive Surgical Margins Rate and EGFR Family Members Expression in Prostate Cancer Treated With Bicalutamide - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Positive Surgical Margins Rate and EGFR Family Members Expression in Prostate Cancer Treated With Bicalutamide The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00421694 Recruitment Status : Completed First Posted : January 12, 2007

2007 Clinical Trials

113126. A Radiation Badge Survey for Family Members Living with Patients Treated with a (103)Pd Permanent Breast Seed Implant. (PubMed)

A Radiation Badge Survey for Family Members Living with Patients Treated with a (103)Pd Permanent Breast Seed Implant. Sixty-seven patients with early-stage breast cancer were treated in a Phase I/II clinical trial using a (103)Pd permanent breast seed implant as adjuvant radiotherapy after breast-conserving surgery. We report the dose received by family members living with these patients and compare measured doses with theoretical worst-case scenario estimates.Exposure-rate measurements were (...) taken at 1 m from the patient by using a calibrated low-energy survey meter. Landauer (Landauer Inc., Glenwood, IL) Luxel badges, with sensitivity of 0.01 mSv, were given to family members to wear after the implantation. Badge readings for 33 spouses and 28 other family members were used to estimate effective doses, and these were compared with theory.Average preimplantation planning target volume from computed tomography was 50.3 ml (range, 18.0-96.7 ml), and average preimplantation distance

2007 Biology and Physics

113127. Comparison of Stress Experienced by Family Members of Patients Treated in Hospital at Home with That of Those Receiving Traditional Acute Hospital Care. (PubMed)

Comparison of Stress Experienced by Family Members of Patients Treated in Hospital at Home with That of Those Receiving Traditional Acute Hospital Care. To compare differences in the stress experienced by family members of patients cared for in a physician-led substitutive Hospital at Home (HaH) and those receiving traditional acute hospital care.Survey questionnaire completed as a component of a prospective, nonrandomized clinical trial of a substitutive HaH care model.Three Medicare managed (...) care health systems and a Veterans Affairs Medical Center.Two hundred fourteen community-dwelling elderly patients who required acute hospital admission for community-acquired pneumonia, exacerbation of chronic heart failure, exacerbation of chronic obstructive pulmonary disease, or cellulitis.Treatment in a substitutive HaH model.Fifteen-question survey questionnaire asking family members whether they experienced a potentially stressful situation and, if so, whether stress was associated

2007 Journal of the American Geriatrics Society

113128. Effectiveness of two models of brief family education: retention of gains by family members of adults with serious mental illness. (PubMed)

Effectiveness of two models of brief family education: retention of gains by family members of adults with serious mental illness. The retention of benefits from two models of family education was compared with maturational effects in an untreated control group. The three-month interventions showed an initial effect for self-efficacy regarding a mentally ill relative that did not significantly diminish during the following six months. However, no significant differences on this measure were (...) found between the treated groups and the untreated controls. Ways of refining the interventions and measures so as to improve gains and retain them over time are discussed.

1997 The American journal of orthopsychiatry

113129. Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells. (PubMed)

Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells. The POU family of proteins binds specifically to octamer DNA motifs present in the promoters of several genes and regulates their expression. We identified the presence of four members of the POU family of proteins, Oct-1, Oct-2, Oct-T1, and Oct-T2, in the human T-cell line Jurkat. To obtain insight into the physiological role played by these proteins (...) in T cells, we studied the time course of expression of these genes in resting, activated, and phorbol 12-myristate 13-acetate (PMA)-treated cells. The expression of the gene encoding Oct-1 (now assigned the name OTF1 for octamer-binding transcription factor 1) remained unchanged and the levels of Oct-T2 mRNA decreased with increasing time of incubation to undetectable amounts in all three states of T-cell growth. The levels of Oct-2 mRNA and protein were increased in activated cells, were

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1993 Proceedings of the National Academy of Sciences of the United States of America

113130. Family members of patients treated for ESRD have high rates of undetected kidney disease. (PubMed)

Family members of patients treated for ESRD have high rates of undetected kidney disease. Early intervention during the course of chronic kidney disease (CKD) may delay the progression to end-stage renal disease (ESRD). Several studies have reported that relatives of patients with ESRD are at risk for kidney disease (KD), but little is known about the prevalence and awareness of CKD in this population, which is the object of this report.We conducted a cross-sectional survey by way (...) of a voluntary screening of relatives of patients with ESRD in 10 communities in one southeastern state. Age; race; sex; family and personal history of KD, hypertension, and diabetes; height; weight; and blood pressure were determined. Proteinuria and random blood glucose and serum creatinine were measured. Creatinine clearance (CrCl) was assessed using the Cockroft-Gault formula.Among 769 screened adults, 29.2% with a family history of ESRD were included in the study sample. CKD (CrCl < 90 mL/min

2002 American Journal of Kidney Diseases

113131. Treating family members: call your doctor in the morning. (PubMed)

Treating family members: call your doctor in the morning. 12228955 2002 10 08 2009 11 11 0008-350X 48 2002 Aug Canadian family physician Medecin de famille canadien Can Fam Physician Treating family members: call your doctor in the morning. 1292 Clarfield A Mark AM eng Comment Letter Canada Can Fam Physician 0120300 0008-350X IM Can Fam Physician. 2002 Mar;48:546-7, 550-2 11935719 Emergency Medical Services Family Health Family Practice Family Relations Hospitals, Community Humans Referral

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2002 Canadian Family Physician

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