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Treating Family Members

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21. Late Transitions and Bereaved Family Member Perceptions of Quality of End-of-Life Care. Full Text available with Trip Pro

Late Transitions and Bereaved Family Member Perceptions of Quality of End-of-Life Care. To examine associations between healthcare transitions at the end of life (EOL; late transitions) and bereaved family members' and friends' assessment of EOL quality of care (QOC).National Health and Aging Trends Study (NHATS), a prospective cohort of Medicare enrollees aged 65 and older.United States, all sites of death.Family members and close friends of decedents from NHATS Rounds 2 through 6 (N=1,653 (...) ; weighted 6.0 million Medicare deaths).Multivariable logistic regression with survey weights was used to examine the association between having a late transition and reports of perceived unmet needs for symptom management, spiritual support, concerns with communication, and overall QOC.Seventeen percent of decedents had a late transition. Bereaved respondents for decedents experiencing late transitions were more likely to report that the decedent was treated without respect (21.3% vs 15.6%; adjusted

2018 Journal of the American Geriatrics Society

22. Brief multifamily Psychoeducation for family members of patients with chronic major depression: a randomized controlled trial. Full Text available with Trip Pro

points, as well as family functioning as evaluated by the patients. Intention-to-treat analyses were conducted.There was no statistically significant effect of BMP on K6 scores at 16- weeks (mean difference 1.17, 95% confidence interval: - 0.63 to 2.98, P = 0.19). Exploratory analyses revealed that BMP reduced depressive symptoms in family members at 8- weeks (difference = - 3.37, 95%CI -6.32 to - 0.43, P = 0.02) and improved family functioning at multiple time points (Role; 8 W, difference = - 0.13 (...) Brief multifamily Psychoeducation for family members of patients with chronic major depression: a randomized controlled trial. Major depressive disorder (MDD) is a common and often chronic problem. Patients with chronic MDD often have negative impacts on the health of their families. Family psychoeducation is recognized as part of the optimal treatment for patients with psychotic disorder, and has been shown to reduce the rate of relapse in individuals with schizophrenia and to reduce

2018 BMC Psychiatry Controlled trial quality: predicted high

23. Stepping Stones for Families’ Family Wellbeing Service: evaluation

October and December 2018 with 30 parents using the Service, eight members of Stepping Stones staff, Stepping Stones CEO, and 19 members of staff at the nurseries hosting the Service. Key findings Impact of the Service on parenting skills, resilience, parent/child and family relationships of parents who engaged with the Service The Service has a clear positive impact on parenting skills and resilience, parent/ child and family relationships. Parents who engage with the Service have a greater range (...) of skills and techniques for managing their children’s behaviour, and are more confident as parents. They are also having more fun outside and inside the home with their children, often as a family. As a result, and because of improvements to child behaviour and parental wellbeing, relationships between parents and children have improved and parents have improved attachment to their children. There is less direct evidence of improvement to parents’ relationships with partners and other family members

2019 Glasgow Centre for Population Health

24. Cell Cycle Arrest and Apoptosis Induction via Modulation of Mitochondrial Integrity by Bcl-2 Family Members and Caspase Dependence in Dracaena cinnabari-Treated H400 Human Oral Squamous Cell Carcinoma Full Text available with Trip Pro

Cell Cycle Arrest and Apoptosis Induction via Modulation of Mitochondrial Integrity by Bcl-2 Family Members and Caspase Dependence in Dracaena cinnabari-Treated H400 Human Oral Squamous Cell Carcinoma Dracaena cinnabari Balf.f. is a red resin endemic to Socotra Island, Yemen. Although there have been several reports on its therapeutic properties, information on its cytotoxicity and anticancer effects is very limited. This study utilized a bioassay-guided fractionation approach to determine (...) externalization of phospholipid phosphatidylserine was observed using DAPI/Annexin V fluorescence double staining mechanism studied through mitochondrial membrane potential assay cytochrome c enzyme-linked immunosorbent and caspases activities revealed depolarization of mitochondrial membrane potential (MMP) and significant activation of caspases 9 and 3/7, concomitant with S phase arrest. Apoptotic proteins array suggested that MMP was regulated by Bcl-2 proteins family as results demonstrated

2016 BioMed research international

25. Evaluation of the prognostic value of all four HER family receptors in patients with metastatic breast cancer treated with trastuzumab: A Hellenic Cooperative Oncology Group (HeCOG) study. Full Text available with Trip Pro

Evaluation of the prognostic value of all four HER family receptors in patients with metastatic breast cancer treated with trastuzumab: A Hellenic Cooperative Oncology Group (HeCOG) study. In the current study, we performed a complete analysis, with four different methods, of all four HER family receptors, in a series of patients with metastatic breast cancer treated with trastuzumab-based regimens and evaluated their prognostic value. Formalin-fixed paraffin-embedded tumor tissue samples were (...) collected from 227 patients, considered to be HER2-positive when assessed at the local laboratories. We evaluated gene amplification, copy number variations (CNVs), mRNA and protein expression of all four HER family members. In addition, our analysis included the evaluation of several other factors by immunohistochemistry (IHC), such as pHER2Tyr1221/1222, pHER2Tyr877 and PTEN. Central review of HER2 status by IHC and fluorescence in situ hybridization revealed that of the 227 patients, only 139 (61.2

2018 PLoS ONE

26. Trajectories of depressive symptoms for bereaved family members of chronically ill patients: a systematic review. (Abstract)

Trajectories of depressive symptoms for bereaved family members of chronically ill patients: a systematic review. To synthesise concepts of distinct depressive-symptom trajectories in published studies by establishing a measurable standard and estimate the prevalence of recategorised trajectories for bereaved families of chronically ill patients.Grieving is a dynamic/individualised process. In studies treating depressive-symptom trajectories as heterogeneous, different criteria were used (...) and improvement over time. The prevalence of recategorised depressive-symptom trajectories was recalculated from published data.We identified six studies, published in 1994-2012, that followed 56-301 bereaved families from eight months to five years. We synthesised five new distinct trajectories (prevalence in synthesised sample): 'endurance' (54·2%), 'resilience' (8·8%), 'transient reaction' (7·7%), 'chronic grief' (19·4%) and 'chronic depression' (9·9%). The 'endurance' group experienced low depressive

2017 Journal of clinical nursing

27. SAFER: A Brief Intervention Involving Family Members in Suicide Safety Planning

SAFER: A Brief Intervention Involving Family Members in Suicide Safety Planning SAFER: A Brief Intervention Involving Family Members in Suicide Safety Planning - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . SAFER: A Brief Intervention Involving Family Members in Suicide Safety Planning (SAFER) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03034863 Recruitment Status : Recruiting First Posted : January 27, 2017 Last Update

2017 Clinical Trials

28. E2F-1 targets miR-519d to regulate the expression of the ras homolog gene family member C Full Text available with Trip Pro

E2F-1 targets miR-519d to regulate the expression of the ras homolog gene family member C E2F1 (E2F transcription factor 1) can act as a tumor suppressor or oncogene. We report the molecular mechanism of E2F1 in ovarian carcinoma tumorigenesis and progression. E2F1 expression levels in ovarian carcinoma tissue were examined by immunohistochemistry. After E2F1 plasmid transfection and E2F1-microRNA-519d (miR-519d)/si-RhoC (Ras homolog gene family member C) co-transfection, ovarian cancer cell (...) is a promising signaling pathway for diagnosing and treating ovarian carcinoma.

2017 Oncotarget

29. Perspectives of Family Members on Using Technology in Youth Mental Health Care: A Qualitative Study Full Text available with Trip Pro

technology to deliver mental health services to youth, and recommendations to use technology for (1) providing quality information in a manner that is accessible to individuals of diverse socioeconomic backgrounds, (2) facilitating communication with health care professionals and services, and (3) increasing access to peer support.To our knowledge, this is among the first (or the first) to explore the perspectives of family members of youth being treated for FEP on the use of technology for mental health (...) Perspectives of Family Members on Using Technology in Youth Mental Health Care: A Qualitative Study Information and communication technologies (ICTs) are increasingly recognized as having an important role in the delivery of mental health services for youth. Recent studies have evaluated young people's access and use of technology, as well as their perspectives on using technology to receive mental health information, services, and support; however, limited attention has been given

2017 JMIR mental health

30. Pine bark extract (Pycnogenol®) suppresses cigarette smoke-induced fibrotic response via transforming growth factor-β1/Smad family member 2/3 signaling Full Text available with Trip Pro

Pine bark extract (Pycnogenol®) suppresses cigarette smoke-induced fibrotic response via transforming growth factor-β1/Smad family member 2/3 signaling Chronic obstructive pulmonary diseases (COPD) is an important disease featured as intense inflammation, protease imbalance, and air flow limitation and mainly induced by cigarette smoke (CS). In present study, we explored the effects of Pycnogenol® (PYC, pine bark extract) on pulmonary fibrosis caused by CS+lipopolysaccharide (LPS) exposure (...) . Furthermore, transforming growth factor-β1 (TGF-β1) expression and Smad family member 2/3 (Smad 2/3) phosphorylation were effectively suppressed by PYC treatment. PYC markedly reduced the collagen deposition caused by CS+LPS exposure, which was closely involved in TGF-β1/Smad 2/3 signaling, which is associated with pulmonary fibrotic change. These findings suggest that treatment with PYC could be a therapeutic strategy for controlling COPD progression.

2017 Laboratory animal research

31. Effect of praziquantel on the differential expression of mouse hepatic genes and parasite ATP binding cassette transporter gene family members during Schistosoma mansoni infection Full Text available with Trip Pro

Effect of praziquantel on the differential expression of mouse hepatic genes and parasite ATP binding cassette transporter gene family members during Schistosoma mansoni infection Schistosomiasis is a chronic parasitic disease caused by sexually dimorphic blood flukes of the genus Schistosoma. Praziquantel (PZQ) is the only drug widely available to treat the disease but does not kill juvenile parasites. Here we report the use of next generation sequencing to study the transcriptional effect (...) to induce transcription of any of the 9 genes encoding ATP-binding cassette (ABC) transporters tested. In contrast, juvenile schistosomes were able to significantly induce the activities of ABCB, C and G family members, underscoring the possibility that these efflux systems play a major role in drug resistance.

2017 PLoS neglected tropical diseases

32. Elucidating the role of highly homologous Nicotiana benthamiana ubiquitin E2 gene family members in plant immunity through an improved virus-induced gene silencing approach Full Text available with Trip Pro

family have remained to date a significant challenge in VIGS due to silencing of off-targets.Here we present an improved method for the selection and evaluation of gene fragments used for VIGS to specifically and efficiently knock down members of a highly homologous gene family. Using this method, we knocked down twelve and four members, respectively of group III of the gene family encoding ubiquitin-conjugating enzymes (E2) in Nicotiana benthamiana. Assays using these VIGS-treated plants revealed (...) Elucidating the role of highly homologous Nicotiana benthamiana ubiquitin E2 gene family members in plant immunity through an improved virus-induced gene silencing approach Virus-induced gene silencing (VIGS) has been used in many plant species as an attractive post transcriptional gene silencing (PTGS) method for studying gene function either individually or at large-scale in a high-throughput manner. However, the specificity and efficiency for knocking down members of a highly homologous gene

2017 Plant methods

33. Kaiso protects human umbilical vein endothelial cells against apoptosis by differentially regulating the expression of B-cell CLL/lymphoma 2 family members Full Text available with Trip Pro

Kaiso protects human umbilical vein endothelial cells against apoptosis by differentially regulating the expression of B-cell CLL/lymphoma 2 family members Endothelial cell injury can promote the development of various cardiovascular diseases, thus, fully understanding the mechanisms underlying the maintenance of vascular endothelial cell homoeostasis may help prevent and treat cardiovascular disease. Kaiso, a zinc finger and BTB domain containing transcription factor, is key to embryonic

2017 Scientific reports

34. The experiences of family members in the year following the diagnosis of a child or adolescent with cancer: a qualitative systematic review. (Abstract)

in their lives and disruptions to their plans for the future. Health professionals should be encouraged to provide clear information to the whole family in relation to the treatment plan and caring strategies for the child. Nurses should provide family members with strategies to help with the normalization of their life and a return to their previous pre-cancer lifestyle. The medical team should exhibit professionalism and skills when treating the cancer in order to enhance the child’s and his/her family (...) The experiences of family members in the year following the diagnosis of a child or adolescent with cancer: a qualitative systematic review. Research shows that it is stressful for family members when a child or an adolescent within the family unit is diagnosed with cancer and this stress continues over the course of the year after the diagnosis. Qualitative studies have been conducted aimed at exploring parental, siblings' and other family members' experiences when facing health-illness

2015 JBI database of systematic reviews and implementation reports

35. Treat your family like you treat your patients

Treat your family like you treat your patients Treat your family like you treat your patients Treat your family like you treat your patients | | January 24, 2019 45 Shares Many times during difficult patient interactions — when I am not sure about the right thing to do — I let myself be guided by the question: “What would I do if it was my family member?” This internal dialogue usually cuts the clutter and lets me focus on the most important thing: the well-being of my patient. I can step away (...) volunteer obligations I have for the school that week. My husband asks me a simple question which offends me for no reason, and I snap at him feeling somewhat entitled to my rude behavior because I’ve worked hard all day. Then I regret it immediately as I realize that he has been working hard too. I apologize and think how wonderful it would be if I treated my family like I treat my patients. If I treated my family as my patients, I would listen attentively and empathetically when my parents call

2019 KevinMD blog

36. Cost-effectiveness of genetic testing in family members of patients with long-QT syndrome Full Text available with Trip Pro

Cost-effectiveness of genetic testing in family members of patients with long-QT syndrome Cost-effectiveness of genetic testing in family members of patients with long-QT syndrome Cost-effectiveness of genetic testing in family members of patients with long-QT syndrome Perez MV, Kumarasamy NA, Owens DK, Wang PJ, Hlatky MA Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods (...) -blockers and the efficacy of treatment were also influential parameters. The cost-utility of genetic testing was below the threshold of $50,000 per QALY when the annual risk of death was 0.48% or more, if genetic testing provided pharmacogenomic information, or with an increasing number of family members to be tested (two or more; the cost of testing the index case was only incurred once). Watchful waiting was the preferred strategy in relatives with a low pre-test probability of LQTS, genetic testing

2011 NHS Economic Evaluation Database.

37. Computer Assisted Family Intervention to Treat Self-Harm Disparities in Latinas and Sexual/Gender Minority Youth

Computer Assisted Family Intervention to Treat Self-Harm Disparities in Latinas and Sexual/Gender Minority Youth Computer Assisted Family Intervention to Treat Self-Harm Disparities in Latinas and Sexual/Gender Minority Youth - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Computer Assisted Family Intervention to Treat Self-Harm Disparities in Latinas and Sexual/Gender Minority Youth The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov

2018 Clinical Trials

38. How a concerned family member, friend or member of the public can help someone with gambling problems: a Delphi consensus study Full Text available with Trip Pro

How a concerned family member, friend or member of the public can help someone with gambling problems: a Delphi consensus study Gambling is an enjoyable recreational pursuit for many people. However, for some it can lead to significant harms. The Delphi expert consensus method was used to develop guidelines for how a concerned family member, friend or member of the public can recognise the signs of gambling problems and support a person to change their gambling.A systematic review of websites (...) , books and journal articles was conducted to develop a questionnaire containing items about the knowledge, skills and actions needed for supporting a person with gambling problems. These items were rated over three rounds by two international expert panels comprising people with a lived experience of gambling problems and professionals who treat people with gambling problems or research gambling problems.A total of 66 experts (34 with lived experience and 32 professionals) rated 412 helping

2016 BMC psychology

39. Cannabidiol with clobazam for treating seizures associated with Lennox–Gastaut syndrome

23 5 Appraisal committee members and NICE project team 24 Appraisal committee members 24 NICE project team 24 Cannabidiol with clobazam for treating seizures associated with Lennox–Gastaut syndrome (TA615) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 3 of 251 1 Recommendations Recommendations 1.1 Cannabidiol with clobazam is recommended as an option for treating seizures associated with Lennox–Gastaut syndrome (...) syndrome affects families and carers. People with the disease need round-the-clock care, and help with almost all aspects of daily life. Families and carers may find looking after people with Lennox–Gastaut syndrome demanding, and that it prevents them from leading normal lives, including spending less time with their other children. Also, the anxiety that a child with Lennox–Gastaut syndrome may be injured because of a drop seizure can significantly affect the mental wellbeing of all family members

2020 National Institute for Health and Clinical Excellence - Technology Appraisals

40. Cannabidiol with clobazam for treating seizures associated with Dravet syndrome

, the company and patient groups stated that family members not directly involved in caring, particularly siblings, may also benefit Cannabidiol with clobazam for treating seizures associated with Dravet syndrome (TA614) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 19 of 25from their relatives' seizures being better controlled. The committee concluded that it was appropriate to include carers' quality of life (...) Appraisal committee members and NICE project team 24 Appraisal committee members 24 NICE project team 24 Cannabidiol with clobazam for treating seizures associated with Dravet syndrome (TA614) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 3 of 251 1 Recommendations Recommendations 1.1 Cannabidiol with clobazam is recommended as an option for treating seizures associated with Dravet syndrome in people aged 2 years

2020 National Institute for Health and Clinical Excellence - Technology Appraisals

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