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Treating Family Members

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181. Certolizumab pegol and secukinumab for treating active psoriatic arthritis after inadequate response to DMARDs

Certolizumab pegol and secukinumab for treating active psoriatic arthritis after inadequate response to DMARDs Certolizumab pegol and secukinumab for Certolizumab pegol and secukinumab for treating activ treating active psoriatic arthritis after e psoriatic arthritis after inadequate response to DMARDs inadequate response to DMARDs T echnology appraisal guidance Published: 24 May 2017 nice.org.uk/guidance/ta445 © NICE 2018. All rights reserved. Subject to Notice of rights (https (...) to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Certolizumab pegol and secukinumab for treating active psoriatic arthritis after inadequate response to DMARDs (TA445) © NICE 2018. All rights

2017 National Institute for Health and Clinical Excellence - Technology Appraisals

182. Obeticholic acid for treating primary biliary cholangitis

discussion 7 Clinical management of primary biliary cholangitis 7 Clinical effectiveness of obeticholic acid 9 Adverse events 10 Cost effectiveness 10 Innovation 15 Other considerations 15 Pharmaceutical Price Regulation Scheme (PPRS) 2014 16 Summary of appraisal committee's key conclusions 16 5 Implementation 22 6 Appraisal committee members and NICE project team 23 Appraisal committee members 23 NICE project team 23 Obeticholic acid for treating primary biliary cholangitis (TA443) © NICE 2018. All (...) of the discount to the relevant NHS organisations. Any enquiries from NHS organisations about the patient access scheme should be directed to Ruth Nasr on 020 3805 7531 or email ruth.nasr@interceptpharma.com. Obeticholic acid for treating primary biliary cholangitis (TA443) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 22 of 246 6 Appr Appraisal committee me aisal committee members and NICE project team mbers and NICE

2017 National Institute for Health and Clinical Excellence - Technology Appraisals

183. Apremilast for treating active psoriatic arthritis

Clinical effectiveness 9 Cost effectiveness 11 Rapid review 18 Summary of appraisal committee's key conclusions 22 5 Implementation 29 6 Appraisal committee members and NICE project team 30 Appraisal committee members 30 NICE project team 30 Apremilast for treating active psoriatic arthritis (TA433) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 3 of 31This guidance replaces TA372. 1 1 Recommendations Recommendations (...) Apremilast for treating active psoriatic arthritis Apremilast for treating activ Apremilast for treating active psoriatic e psoriatic arthritis arthritis T echnology appraisal guidance Published: 22 February 2017 nice.org.uk/guidance/ta433 © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility The recommendations in this guidance represent the view of NICE, arrived at after careful

2017 National Institute for Health and Clinical Excellence - Technology Appraisals

184. Ibrutinib for previously treated chronic lymphocytic leukaemia and untreated chronic lymphocytic leukaemia with 17p deletion or TP53 mutation

of appraisal committee's key conclusions 22 5 Implementation 30 6 Appraisal committee members, guideline representatives and NICE project team 31 Appraisal committee members 31 NICE project team 31 Ibrutinib for previously treated chronic lymphocytic leukaemia and untreated chronic lymphocytic leukaemia with 17p deletion or TP53 mutation (TA429) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 3 of 321 1 Recommendations (...) Ibrutinib for previously treated chronic lymphocytic leukaemia and untreated chronic lymphocytic leukaemia with 17p deletion or TP53 mutation Ibrutinib for pre Ibrutinib for previously treated chronic viously treated chronic lymphocytic leukaemia and untreated lymphocytic leukaemia and untreated chronic lymphocytic leukaemia with 17p chronic lymphocytic leukaemia with 17p deletion or TP53 mutation deletion or TP53 mutation T echnology appraisal guidance Published: 25 January 2017 nice.org.uk

2017 National Institute for Health and Clinical Excellence - Technology Appraisals

185. Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia

guidance 241) 19 Cancer Drugs Fund partial reconsideration of NICE technology appraisal guidance 241 19 Summary of appraisal committee's key conclusions 21 5 Implementation 31 6 Appraisal committee members and NICE project team 32 Appraisal committee members 32 NICE project team 32 Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia (TA425) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms (...) Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia Dasatinib, nilotinib and high-dose Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or imatinib for treating imatinib-resistant or intoler intolerant chronic m ant chronic my yeloid leukaemia eloid leukaemia T echnology appraisal guidance Published: 21 December 2016 nice.org.uk/guidance/ta425 © NICE 2018. All rights reserved. Subject to Notice of rights

2017 National Institute for Health and Clinical Excellence - Technology Appraisals

186. Eribulin for treating locally advanced or metastatic breast cancer after 2 or more chemotherapy regimens

members and NICE project team 24 Appraisal committee members 24 NICE project team 24 Eribulin for treating locally advanced or metastatic breast cancer after 2 or more chemotherapy regimens (TA423) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 3 of 25This guidance replaces TA250. This guidance should be read in conjunction with TA515. 1 1 Recommendations Recommendations 1.1 Eribulin is recommended as an option (...) with locally advanced or metastatic breast cancer, whose disease has progressed after at least 2 chemotherapy regimens. The committee concluded that eribulin is particularly valuable, and has been more widely used, for HER2-negative disease because this has fewer treatment options. It also recognised that the availability of additional treatment options for advanced disease would be valued by patients and their families. 4.1 to 4.3 The technology The technology Eribulin for treating locally advanced

2017 National Institute for Health and Clinical Excellence - Technology Appraisals

187. “Beholders” or patients and families?

and their families should be driving treatment decisions, supplemented by the evidence from clinical trials and the experience of treating clinicians. References Hutchinson PJ, Kolias AG, Menon DK. Craniectomy for Traumatic Intracranial Hypertension. New England Journal of Medicine. 2016; 375(24):2403-4. [ ] Muehlschlegel S, Shutter L, Col N, Goldberg R. Decision Aids and Shared Decision-Making in Neurocritical Care: An Unmet Need in Our NeuroICUs. Neurocritical Care. 2015; 23(1):127-30. [ ] Hutchinson PJ (...) that many will decline DC unless they know their family members are fiercely independent. Making this decision whilst stricken by grief is an unenviable position to be in as the math makes it very difficult for us to be able to honestly guide them in one direction or another says Thanks David! An issue that hasn’t been discussed in these blogposts – and is outside of the remit of the bedside healthcare professional – are the wider societal implications. In age of exploding healthcare costs, should

2017 Life in the Fast Lane Blog

188. “Beholders” or patients and families?

and their families should be driving treatment decisions, supplemented by the evidence from clinical trials and the experience of treating clinicians. References Hutchinson PJ, Kolias AG, Menon DK. Craniectomy for Traumatic Intracranial Hypertension. New England Journal of Medicine. 2016; 375(24):2403-4. [ ] Muehlschlegel S, Shutter L, Col N, Goldberg R. Decision Aids and Shared Decision-Making in Neurocritical Care: An Unmet Need in Our NeuroICUs. Neurocritical Care. 2015; 23(1):127-30. [ ] Hutchinson PJ (...) that many will decline DC unless they know their family members are fiercely independent. Making this decision whilst stricken by grief is an unenviable position to be in as the math makes it very difficult for us to be able to honestly guide them in one direction or another says Thanks David! An issue that hasn’t been discussed in these blogposts – and is outside of the remit of the bedside healthcare professional – are the wider societal implications. In age of exploding healthcare costs, should

2017 Life in the Fast Lane Blog

189. The Agenda for Familial Hypercholesterolemia (PubMed)

awareness and to lobby for an improved focus on FH care needs in individual countries. Nevertheless, significant challenges to optimizing FH care exist. These include controversy over the value of universal or cascade cholesterol screening for identifying those with FH, lack of prevention research specific to FH distinct from lipid research in the larger community, and lack of integrated case management protocols across the continuum of care for the family with multiple affected members. The Familial (...) , are pathognomonic for homozygous familial hypercholesterolemia. Figure 5. Cholesterol-lowering treatment has been associated with improved outcomes. Cox proportional hazards model with time-varying benefit from statin therapy comparing treated and untreated personyears for ( A ) survival and ( B ) first major adverse cardiovascular event (MACE) in patients with homozygous familial hypercholesterolemia, with year of birth fixed as mean year of birth. Reproduced from Raal et al. Copyright © 2011, American Heart

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2015 American Heart Association

190. Parent-focused treatment for anorexia in adolescents: more efficient than family-based treatment says new RCT

of the clinical trials that do exist demonstrate that involving family members in treatment often supports more favourable outcomes than treatments with no family involvement. The family that does therapy together, helps one member of that family achieve positive health outcomes together, although that family may have been the cause of the original problems, it’s difficult to say sometimes. This probably won’t catch on as a saying. Current evidence seems to indicate that families can play a role in supporting (...) ), monitoring their mental and medical condition. During parent-focused therapy , the adolescent with anorexia nervosa attends a 15 minute session with the nurse before the parent’s or parents’ session with the therapist. Any pertinent information from the adolescent’s session with the nurse is past onto the therapist when they see the parents for 50 minutes. The therapeutic content of these sessions is the same as in family-based treatment. The family that does therapy separately, helps one member

2016 The Mental Elf

191. Hereditary Colorectal Cancer Syndromes Endorsement of the Familial Risk?Colorectal Cancer ESMO Guideline

and added a few qualifying statements. Recommendations Approximately 5% to 6% of patient cases of CRC are associated with germline mutations that confer an inherited predisposition for cancer. The possibility of a hereditary cancer syndrome should be assessed for every patient at the time of CRC diagnosis. A diagnosis of Lynch syndrome, familial adenomatous polyposis, or another genetic syndrome can influence clinical management for patients with CRC and their family members. Screening for hereditary (...) testimony. In accordance with these procedures, the majority of the members of the panel did not disclose any such relationships (see Author Disclosures of Potential Conflicts of Interest section at the end of the article). CLINICAL QUESTIONS AND TARGET POPULATION Section: The ESMO guidelines addressed clinical questions on prevention, screening, genetics, treatment, and management for people at risk for LS, APC -associated FAP, AFAP, MAP, and familial CRC type X. SUMMARY OF ESMO GUIDELINES DEVELOPMENT

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2014 American Society of Clinical Oncology Guidelines

192. Lojuxta (lomitapide) - familial hypercholesterolaemia

g/l and arterial disease. Individual diagnosis of familial hypercholesterolaemia is the first step in the investigation and management of a family at high risk of cardiovascular disease. It should be done as early as possible, at the silent and reversible phase of arterial disease. Severe familial hypercholesterolaemia is treated by centres specialising in hereditary metabolic disorders. The prognosis is a direct function of the patient's age, LDL-C level and ongoing arterial exposure to a fixed (...) treatments indicated in combination with lipid-lowering treatments at maximum doses in patients with uncontrolled HoFH. The other available medicines for treating HoFH are the following: NAME (INN) Company Same TC* Yes / No Indication Date of opinion AB / IAB (Wording) Reimburs ement Yes/No CRESTOR (rosuvastatin) Astra Zeneca No Homozygous familial hypercholesterolaemia as an adjunct to diet and other lipid- lowering treatments (especially LDL apheresis) or if such treatments are not appropriate. 02/02

2014 Haute Autorite de sante

193. Effectiveness of Family and Caregiver Interventions on Patient Outcomes among Adults with Cancer or Memory-Related Disorders

evidence assessing whether family involved interventions improve patient outcomes (i.e., efficacy) and whether specific family involved interventions are better than alternative ones (i.e., specificity or comparative effectiveness). We specifically examined the effects of family-involved interventions on the patients, not on the family members. We assessed if there is evidence that interventions targeted at family members only or both family members and adult care recipients improve the patients (...) ’ outcomes. We limited our focus to family members caring for those with cancer and memory-related conditions since the majority of studies examine one of these two conditions. This project was nominated by Sonja Batten, PhD, Office of Mental Health Services. The key questions and scope were refined with input from a technical expert panel. We addressed the following key questions: Key Question #1. What are the benefits of family and caregiver psychosocial interventions for adult patients with cancer

2013 Veterans Affairs Evidence-based Synthesis Program Reports

194. New year, new thinking about treating obesity

specialist sooner but for a discouraging or judgmental doctor, family member or friend telling them ‘you don’t need a specialist, you just need a diet and exercise more.’ This kind of thinking keeps people from talking about obesity with their doctors and exploring more effective treatments, and it keeps doctors more focused on treating the medical consequences of obesity rather than treating obesity itself. This is particularly concerning when it comes to severe obesity, where diet and exercise alone (...) effective long-term treatment. In fact, nearly 1 in 5 Americans still think it’s a cosmetic procedure, and 24 percent say they would actually oppose a family member’s or close friend’s decision to have it. Obesity medications are even less popular with the American public, with half saying they support their use for someone with obesity. While weight-loss surgery and obesity medications are not for everyone, they are clearly only being used by a fraction of those who could benefit. The American Society

2019 KevinMD blog

195. Long-term functional and psychological recovery in a population of ARDS patients treated with VV-ECMO and in their caregivers. (PubMed)

Long-term functional and psychological recovery in a population of ARDS patients treated with VV-ECMO and in their caregivers. Acute respiratory distress syndrome (ARDS) survivors are affected with long- term physical/mental impairments, with improvements limited mostly to the first year after inten- sive care (ICU) discharge. Furthermore, caregivers of ICU patients exhibit psychological problems after family-member recovery. We evaluated the long-term physical and mental recovery of ARDS (...) survivors treated with veno-venous extracorporeal membrane oxygenation (VV-ECMO), and the long-term psychological impact on their caregivers.Single-center prospective evaluation of a retrospective cohort of 75 ARDS patients treated with VV-ECMO during a seven-year period (25.10.2009-11.08.2016). Primary outcomes were the 36-Item Short-Form Health-Survey (SF-36, patients only), and risks of depression, anxiety or post-traumatic stress disorder (PTSD), both for patients and their caregivers. We

2019 Minerva anestesiologica

196. Budesonide (Jorveza) - to treat adults with eosinophilic oesophagitis

Budesonide (Jorveza) - to treat adults with eosinophilic oesophagitis 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5520 Send a question via our website www.ema.europa.eu/contact © European Medicines Agency, 2018. Reproduction is authorised provided the source is acknowledged. 09 November 2017 EMA/774645/2017 Assessment report Jorveza International non-proprietary name: budesonide (...) analysis set-double blind (phase) FAS-FU Full analysis set-follow-up (phase) FAS-OLI Full analysis set-open-label induction (phase) FU Follow-up GC Gas Chromatography GERD Gastroesophageal reflux disease hpf High-power field HPLC High performance liquid chromatography ICH International Council for Harmonisation IDMC Independent Data Monitoring Committee IgE Immunoglobulin E IL Interleukin IMP Investigational medicinal product IR Infrared ITT Intention-to-treat LOCF Last observation carried forward LC

2018 European Medicines Agency - EPARs

197. Changes in serum TNF-like weak inducer of apoptosis (TWEAK) levels and Psoriasis Area Severity Index (PASI) scores in plaque psoriasis patients treated with conventional versus anti-TNF treatments. (PubMed)

Changes in serum TNF-like weak inducer of apoptosis (TWEAK) levels and Psoriasis Area Severity Index (PASI) scores in plaque psoriasis patients treated with conventional versus anti-TNF treatments. Psoriasis is a chronic dermatologic disease affecting 2% of the general population. Tumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a newly defined member of the TNF family. Increased serum levels of TWEAK were reported in inflammatory diseases. The relationship between serum

2019 International Journal of Dermatology

198. Oxidation Rates of the Different Substrates During Exercise in Children and Adolescents With Juvenile Idiopathic Arthritis. Case-control Study and Cases Treated / Cases Not Treated With Anti-TNFα

is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 8 Years to 18 Years (Child, Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: Children with juvenile idiopathic arthritis Exclusion (...) Oxidation Rates of the Different Substrates During Exercise in Children and Adolescents With Juvenile Idiopathic Arthritis. Case-control Study and Cases Treated / Cases Not Treated With Anti-TNFα Oxidation Rates of the Different Substrates During Exercise in Children and Adolescents With Juvenile Idiopathic Arthritis. Case-control Study and Cases Treated / Cases Not Treated With Anti-TNFα - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer

2016 Clinical Trials

199. Ibrutinib and Nivolumab in Treating Patients With Previously-Treated Metastatic Kidney Cancer

, overall and by dose. Overall survival [ Time Frame: Up to 6 months ] Will be summarized descriptively by Kaplan-Meier curves and life table estimates. Response [ Time Frame: Up to 6 months ] Assessed by RECIST version 1.1 Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor (...) Ibrutinib and Nivolumab in Treating Patients With Previously-Treated Metastatic Kidney Cancer Ibrutinib and Nivolumab in Treating Patients With Previously-Treated Metastatic Kidney Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2016 Clinical Trials

200. Durvalumab and Tremelimumab in Treating Patients With Muscle-Invasive, High-Risk Urothelial Cancer That Cannot Be Treated With Cisplatin-Based Therapy Before Surgery

of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria (...) Durvalumab and Tremelimumab in Treating Patients With Muscle-Invasive, High-Risk Urothelial Cancer That Cannot Be Treated With Cisplatin-Based Therapy Before Surgery Durvalumab and Tremelimumab in Treating Patients With Muscle-Invasive, High-Risk Urothelial Cancer That Cannot Be Treated With Cisplatin-Based Therapy Before Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x

2016 Clinical Trials

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