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Travelers Diarrhea

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121. Aseptic abscess syndrome associated with traveler’s diarrhea after a trip to Malaysia (PubMed)

Aseptic abscess syndrome associated with traveler’s diarrhea after a trip to Malaysia The first, to our knowledge, case of the aseptic abscesses syndrome as a complication of traveler's diarrhea after a trip to Malaysia is presented. The patient failed to respond to several antimicrobials. The diagnosis was histologically confirmed and the patient only responded to immunomodulatory therapy with corticosteroids and methotrexate. Travel physicians should be aware of this entity reviewed herein (...) in the context of traveler's diarrhea.

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2016 IDCases

122. Incidence, Etiology and Risk Factors for Travelers’ Diarrhea during a Hospital Ship-Based Military Humanitarian Mission: Continuing Promise 2011 (PubMed)

Incidence, Etiology and Risk Factors for Travelers’ Diarrhea during a Hospital Ship-Based Military Humanitarian Mission: Continuing Promise 2011 Travelers' diarrhea (TD) is the most common ailment affecting travelers, including deployed U.S. military. Continuing Promise 2011 was a 5-month humanitarian assistance/disaster response (HA/DR) military and non-governmental organization training mission aboard the hospital ship USNS Comfort, which deployed to Central and South America

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2016 PloS one

123. Multiplex-Touchdown PCR to Simultaneously Detect Cryptosporidium parvum, Giardia lamblia, and Cyclospora cayetanensis, the Major Causes of Traveler’s Diarrhea (PubMed)

Multiplex-Touchdown PCR to Simultaneously Detect Cryptosporidium parvum, Giardia lamblia, and Cyclospora cayetanensis, the Major Causes of Traveler’s Diarrhea This study aimed to develop a multiplex-touchdown PCR method to simultaneously detect 3 species of protozoan parasites, i.e., Cryptosporidium parvum, Giardia lamblia, and Cyclospora cayetanensis, the major causes of traveler's diarrhea and are resistant to standard antimicrobial treatments. The target genes included the Cryptosporidium

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2016 The Korean journal of parasitology

124. Use of a Dietary Supplement to Support Digestive Health in Children With Chronic Diarrhea

Use of a Dietary Supplement to Support Digestive Health in Children With Chronic Diarrhea Use of a Dietary Supplement to Support Digestive Health in Children With Chronic Diarrhea - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Use of a Dietary Supplement to Support Digestive Health in Children With Chronic Diarrhea The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02856386 Recruitment Status : Unknown Verified August 2016 by LiveLeaf Inc.. Recruitment status was: Not yet recruiting First Posted

2016 Clinical Trials

125. A Case of an 11-year-old With Cough, Diarrhea, and Findings of Concern in His Lungs and Spleen. (PubMed)

A Case of an 11-year-old With Cough, Diarrhea, and Findings of Concern in His Lungs and Spleen. This is the case of a previously healthy, 11-year-old male of Indian descent who presented to the emergency department with a 2-month history of nausea, vomiting, diarrhea, fatigue, cough, and 7-lb weight loss. Acutely, he developed 5 days of fever as high as 39.4°C. He had a remote travel history to the Middle East. On physical examination, he was febrile and tachycardic, was thin but otherwise had

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2016 Pediatrics

126. TRAVELER’S DIARRHEA (PubMed)

TRAVELER’S DIARRHEA Traveler's diarrhea (TD) is the most common travel-related illness, and it can have a significant impact on the traveler. Pretravel consultation provides an excellent opportunity for the clinician to counsel the traveler and discuss strategies such as food and water hygiene, vaccinations, and medications for prophylaxis or self-treatment that may decrease the incidence and impact of TD. Postinfectious sequelae, such as postinfectious irritable bowel syndrome, reactive

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2016 The Medical clinics of North America

127. Diarrhea in Children

Diarrhea in Children Diarrhea in Children Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Diarrhea in Children Diarrhea in Children (...) Aka: Diarrhea in Children , Pediatric Diarrhea , Pediatric Gastroenteritis , Gastroenteritis in Children , Acute Gastroenteritis in Children From Related Chapters II. Epidemiology U.S. Outpatient Visits: 1.5 Million per year U.S. Hospitalizations: 200,000 per year Deaths U.S.: 300 per year World: 2.5 Million per year (age under 5 years) Fifth leading cause of death in children worldwide) III. Definitions: Diarrhea See ral See Sudden increased stool frequency and looseness Three or more watery

2018 FP Notebook

128. Infectious Diarrhea Causes

Infectious Diarrhea Causes Aka: Infectious Diarrhea Causes From Related Chapters II. Causes: Bacteria Toxigenic (Enterotoxin binds : secretory, account for 80% of ) ( ) Most common in the returning traveler Contaminated water ingestion is the classic, historical example (shellfish ingestion can also occur) Associated with rice-water stools, severe dehydration, Ingestion of well or spring water (esp. in young children or immunocompromised patients) Most common , rapid onset within hours (esp. eggs (...) Infectious Diarrhea Causes Infectious Diarrhea Causes Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Infectious Diarrhea Causes

2018 FP Notebook

129. Chronic Diarrhea

Chronic Diarrhea Chronic Diarrhea Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Chronic Diarrhea Chronic Diarrhea Aka: Chronic (...) Diarrhea From Related Chapters II. Definition Persistent >4 weeks III. Causes Large volume stools >1 L/day and not better over night or with g (diagnosis of exclusion) Small volume stools (<350 ml/day and better over night and with g) IV. History Age Young patients Functional bowel disorder ( ) Older patients pattern alternates with abuse Functional bowel disorder ( ) Intermittent Functional bowel disorder ( ) Malabsorption Persistent abuse Differentiating from or proximal colon involved Large stool

2018 FP Notebook

130. Acute Diarrhea

es (30-40% of episodes) (90% of non- l diarhea) and s (20-30% of episodes) Inflammatory Diarrhea from and s (most common ) Shiga-toxin producing (e.g. :H7, ) Causes 30% of infectious bloody Diarrhea Non-inflammatory Diarrhea from and s Bacillus cereus VII. Risk Factors See for systemic medical condition causes of Diarrhea See Recent travel to endemic area See Travel to a developing area is associated with a 25% chance of developing Diarrhea Those with Diarrhea in a developing area have an 80 (...) % chance of Bacterial Diarrhea Food associated illness See Associated with raw meats, poultry, fish, seafood, milk, rice Wilderness travel (or in developing country) See Hiking in wilderness areas (especially drinking from mountain streams) Consider , , Cryptospordium Day care exposure Consider , , , High-risk sexual behavior See Fecal-oral sexual contact: , , , Protozoa Receptive anal intercourse: , , , Antibiotic use within 6 months or recent hospitalizations See C. Difficile in unexplained Diarrhea

2018 FP Notebook

131. Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins (PubMed)

Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins Secretory diarrheas caused by bacterial enterotoxins, including cholera and traveler's diarrhea, remain a major global health problem. Inappropriate activation of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel occurs in these diarrheas. We previously reported that the benzopyrimido-pyrrolo-oxazinedione (R)-BPO-27 inhibits CFTR (...) chloride conductance with low-nanomolar potency. Here, we demonstrate using experimental mouse models and human enterocyte cultures the potential utility of (R)-BPO-27 for treatment of secretory diarrheas caused by cholera and Escherichia coli enterotoxins. (R)-BPO-27 fully blocked CFTR chloride conductance in epithelial cell cultures and intestine after cAMP agonists, cholera toxin, or heat-stable enterotoxin of E. coli (STa toxin), with IC50 down to ∼5 nM. (R)-BPO-27 prevented cholera toxin and STa

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2016 The FASEB Journal

132. Passive antibodies derived from intramuscularly immunized toxoid fusion 3xSTaN12S-dmLT protect against STa+ enterotoxigenic Escherichia coli (ETEC) diarrhea in a pig model (PubMed)

Passive antibodies derived from intramuscularly immunized toxoid fusion 3xSTaN12S-dmLT protect against STa+ enterotoxigenic Escherichia coli (ETEC) diarrhea in a pig model Enterotoxigenic Escherichia coli (ETEC) strains are among the most common causes of children's diarrhea and travelers' diarrhea. Developing effective vaccines against ETEC associated diarrhea becomes a top priority. ETEC heat-labile toxin (LT) and heat-stable toxin (STa) toxoid fusion 3xSTaN12S-dmLT was demonstrated recently (...) to induce neutralizing antitoxin antibodies in intraperitoneally or subcutaneously immunized mice. However, whether antibodies derived from this toxoid fusion are protective against ETEC diarrhea has not been examined. In this study, we intramuscularly immunized pregnant gilts with toxoid fusion 3xSTaN12S-dmLT, challenged suckling piglets with a STa-positive ETEC strain, and assessed protective efficacy of passive acquire antitoxin antibodies against ETEC diarrhea. Data showed all three immunized gilts

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2016 Vaccine

133. pic gene of enteroaggregative Escherichia coli and its association with diarrhea in Peruvian children (PubMed)

pic gene of enteroaggregative Escherichia coli and its association with diarrhea in Peruvian children Enteroaggregative Escherichia coli (EAEC) causes acute and persistent diarrhea among children, HIV-infected patients, and travelers to developing countries. We have searched for 18 genes-encoding virulence factors associated with aggregative adherence, dispersion, biofilm, toxins, serine protease autotransporters of Enterobacteriaceae (SPATEs) and siderophores, analyzed in 172 well (...) -characterized EAEC strains (aggR(+)) isolated from stool samples of 97 children with diarrhea and 75 healthy controls from a passive surveillance diarrhea cohort study in Peru. Eighty-one different genetic profiles were identified, 37 were found only associated with diarrhea and 25 with control samples. The most frequent genetic profile was aggC(+)aatA(+)aap(+)shf(+)fyuA(+), present in 19 strains, including diarrhea and controls. The profile set1A(+)set1B(+)pic(+) was associated with diarrhea (P < 0.05

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2016 Pathogens and disease

134. MKSAP: 25-year-old woman with diarrhea for 2 days

MKSAP: 25-year-old woman with diarrhea for 2 days MKSAP: 25-year-old woman with diarrhea for 2 days MKSAP: 25-year-old woman with diarrhea for 2 days | | October 22, 2016 8 Shares Test your medicine knowledge with the , in partnership with the . A 25-year-old woman e-mails her internist from Mexico with a report of diarrhea for 2 days. She is traveling and reports three to four loose bowel movements per day. She has been dining in the hotel restaurants but has also consumed foods and bottled (...) is the most appropriate treatment recommendation for this patient? A: Begin levofloxacin and loperamide now B: Begin levofloxacin now and start loperamide 24 hours later C: Begin loperamide now D: No further treatment unless symptoms worsen MKSAP Answer and Critique The correct answer is D: No further treatment unless symptoms worsen. Fluid replacement with aggressive oral hydration without further treatment is the most appropriate treatment recommendation for this patient with mild travelersdiarrhea

2016 KevinMD blog

135. Are Pharmacists Ready for a Greater Role in Travel Health? An Evaluation of the Knowledge and Confidence in Providing Travel Health Advice of Pharmacists Practicing in a Community Pharmacy Chain in Alberta, Canada. (PubMed)

in providing travel-related advice to patients.A web-based survey was developed and distributed to 84 pharmacists practicing in a mid-size pharmacy chain in Alberta, Canada. The survey included knowledge and confidence assessment components. To assess knowledge, pharmacists were provided two cases, along with multiple-choice questions examining pre-travel risk assessment, and advice on travel at altitude, vaccines, malaria, travelers' diarrhea, and other potential travel health risks. Confidence (...) Are Pharmacists Ready for a Greater Role in Travel Health? An Evaluation of the Knowledge and Confidence in Providing Travel Health Advice of Pharmacists Practicing in a Community Pharmacy Chain in Alberta, Canada. Patients often consult community pharmacists for medication needs related to travel, but little is known of pharmacists' knowledge and readiness to provide this care. The aim of this study was to evaluate pharmacists' knowledge in travel health, and to assess their confidence

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2014 Journal of Travel Medicine

136. An 8 year old with diarrhea, abdominal pain, and syncope

An 8 year old with diarrhea, abdominal pain, and syncope Dr. Smith's ECG Blog: An 8 year old with diarrhea, abdominal pain, and syncope Tuesday, May 20, 2014 This case was sent by: Maria Perez Emergency Registrar Monash Medical Centre Melbourne She obtained permission from the family to identify the location or origin of the case. Case This previously completely healthy 8 yo girl complained of diarrhea, vomiting, and upper abdominal pain radiating to the chest, for the past 3 days. There had (...) block. The patient had no family history of sudden death and no recent overseas travel. 3 more ECGs were recorded before the patient could be transferred: There is continued Mobitz II block, variably blocked. Sinus rate remains about 150. Continued Mobitz type II block, now with a regular 2:1 AV block. RBBB and LPFB are still present. Injury pattern continues. Correction to rhythm interpretation by Andreas Roschl: What appear to be P-waves without conduction may, in fact, be T-waves

2014 Dr Smith's ECG Blog

137. A randomized, double-blind, pilot study of rifaximin 550 mg versus placebo in the prevention of travelers' diarrhea in Mexico during the dry season. (PubMed)

A randomized, double-blind, pilot study of rifaximin 550 mg versus placebo in the prevention of travelers' diarrhea in Mexico during the dry season. Rifaximin has been shown to be effective in treating and preventing travelers' diarrhea (TD) during the summer season.The goal of this double-blinded multicenter trial was to assess the efficacy and safety of rifaximin 550 mg administered once daily for 14 days compared with placebo in the prevention of TD during the dry season in Mexico.There were (...) 101 participants randomized. Overall, 25 participants developed TD during the 3 weeks of the study: 22% from the rifaximin group and 29% from the placebo group (p = 0.4). Mild diarrhea (defined as only one or two unformed stools during a 24-h period plus at least one abdominal symptoms) developed in only 3 (6%) participants taking rifaximin compared with 10 (21%) taking placebo during the first week of study (p = 0.03). No clinically significant or serious adverse events were reported.Antibiotic

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2011 Journal of Travel Medicine

138. Inconvenience due to travelers' diarrhea: a prospective follow-up study. (PubMed)

Inconvenience due to travelers' diarrhea: a prospective follow-up study. Limited data exist documenting the degree to which travelers are inconvenienced by travelers' diarrhea (TD). We performed a prospective follow-up study at the travel clinic of Leiden University Medical Center in The Netherlands to determine the degree of inconvenience and to determine how experiencing TD affects travelers' perception.Healthy adults who intended to travel to the (sub)tropics for less than two months were (...) having diarrhea. However, 21% (33/160) were forced to alter their program and an additional 13% (20/160) were confined to their accommodation for one or more daylight days; 53 travelers (33%) used loperamide and 14 (9%) an antibiotic. Eight travelers (5%) consulted a physician for the diarrheal illness. When asked about the degree of inconvenience brought on by the diarrheal illness, 39% categorized it as minor or none at all, 34% as moderate and 27% as large or severe. In those who regarded

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2011 BMC Infectious Diseases

139. Single Nucleotide Polymorphisms in the Promoter of the Gene Encoding the Lipopolysaccharide Receptor CD14 Are Associated With Bacterial Diarrhea in US and Canadian Travelers to Mexico. (PubMed)

Single Nucleotide Polymorphisms in the Promoter of the Gene Encoding the Lipopolysaccharide Receptor CD14 Are Associated With Bacterial Diarrhea in US and Canadian Travelers to Mexico. Under normal conditions, the expression of CD14, which is the principal receptor for bacterial lipopolysaccharide, is down-regulated in the intestinal mucosa but increases in response to inflammatory stimuli. The aim of the present study was to investigate whether fecal CD14 levels increased in response (...) to infection with diarrheagenic Escherichia coli and whether single nucleotide polymorphisms (SNPs) in the CD14 gene were associated with an increased susceptibility to traveler's diarrhea (TD) in US visitors to Mexico.Six SNPs located at the promoter, exon, and untranslated regions of CD14 were typed in a prospective cohort study of 1360 visitors to Mexico at risk for TD. Stools from visitors with TD were studied for enteric pathogens by culture, colony hybridization, and polymerase chain reaction. Fecal

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2011 Clinical Infectious Diseases

140. Incidence and impact of travelers' diarrhea among foreign backpackers in southeast Asia: a result from khao san road, Bangkok. (PubMed)

Incidence and impact of travelers' diarrhea among foreign backpackers in southeast Asia: a result from khao san road, Bangkok. Travelers' diarrhea is the most common disease reported among travelers visiting developing countries, including Southeast Asia, a region visited by large numbers of backpackers each year. Currently, the knowledge of travelers' diarrhea among this group is limited. This study aimed to determine the incidence and impact of travelers' diarrhea in this group.Foreign (...) backpackers in Khao San road, Bangkok, Thailand, were invited to fill out a study questionnaire, in which they were queried about their demographic background, travel characteristics, pretravel preparations and actual practices related to the risk of travelers' diarrhea. For backpackers who had experienced diarrhea, the details and impact of each diarrheal episode were also assessed.In the period April to May 2009, 404 completed questionnaires were collected and analyzed. Sixty percent of participants

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2011 Journal of Travel Medicine

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