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Travelers Diarrhea

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2. Summary of the Committee to Advise on Tropical Medicine and Travel (CATMAT) statement on travellers' diarrhea

Summary of the Committee to Advise on Tropical Medicine and Travel (CATMAT) statement on travellers' diarrhea CATMAT Statement: TravelersDiarrhea - Canada.ca Language selection Search Search Canada.ca Search Menu Main Menu You are here: CATMAT Statement: TravelersDiarrhea Published by: Issue: Date published: November 5, 2015 ISSN: 1481-8531 Submit a manuscript About CCDR Browse Volume 41-11, November 5, 2015: Foodborne Illness Advisory Committee Statement Summary of the Committee to Advise (...) on Tropical Medicine and Travel (CATMAT) Statement on TravelersDiarrhea Libman M 1 , on behalf of CATMAT* Affiliation 1 Division of Infectious Disease, McGill University Health Centre, Montréal, QC Correspondence DOI https://doi.org/10.14745/ccdr.v41i11a03 Abstract Background: Most travellers' diarrhea (TD) infections occur during travel to low- and middle-income countries. Type of travel, duration of stay, age of traveller and presence of certain medical conditions are important factors to consider

2015 CPG Infobase

3. Despite Predominance of Uropathogenic/Extraintestinal Pathotypes Among Travel-acquired Extended-spectrum β-Lactamase-producing Escherichia coli, the Most Commonly Associated Clinical Manifestation Is Travelers' Diarrhea. (PubMed)

Despite Predominance of Uropathogenic/Extraintestinal Pathotypes Among Travel-acquired Extended-spectrum β-Lactamase-producing Escherichia coli, the Most Commonly Associated Clinical Manifestation Is Travelers' Diarrhea. One-third of the 100 million travelers to the tropics annually acquire extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-PE), with undefined clinical consequences.Symptoms suggesting Enterobacteriaceae infections were recorded prospectively among 430 (...) ESBL-PE carriers, manifestations of Enterobacteriaceae infection included travelers' diarrhea (TD) (75/90 subjects) and urinary tract infection (UTI) (3/90). The carriers had 96 ESBL-producing E. coli isolates, 51% exhibiting a molecular pathotype: 13 (14%) were DEC (10 EAEC, 2 EPEC, 1 ETEC) (12 associated with TD) and 39 (41%) ExPEC/UPEC (none associated with UTI). Of ESBL-PE, 3 (3%) were ExPEC/UPEC-EAEC hybrids (2 associated with diarrhea, none with UTI). Potential ESBL-PE infections were

2019 Clinical Infectious Diseases

4. Rifamycin (Aemcolo) - To treat travelers? diarrhea

Rifamycin (Aemcolo) - To treat travelers? diarrhea Drug Approval Package: AEMCOLO (rifamycin) U.S. Department of Health and Human Services Search FDA Submit search Drug Approval Package: AEMCOLO (rifamycin) Company:Cosmo Technologies, Inc. Application Number: 210910Orig 1 Approval Date: 11/16/2018 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. FDA Approval Letter and Labeling (PDF) (PDF) FDA Application Review Files (PDF) (PDF

2019 FDA - Drug Approval Package

5. Estimating the incidence of norovirus acute gastroenteritis among US and European international travelers to areas of moderate to high risk of traveler's diarrhea: a prospective cohort study protocol. (Full text)

Estimating the incidence of norovirus acute gastroenteritis among US and European international travelers to areas of moderate to high risk of traveler's diarrhea: a prospective cohort study protocol. Acute gastroenteritis (AGE) is the leading cause of illness among returning travelers seeking medical care. Multiple types of enteric pathogens can cause travel-acquired AGE and, while bacterial pathogens have a predominant role, the importance of viruses, such as norovirus, is increasingly (...) recognized. There is a lack of information on travel-acquired norovirus incidence among symptomatic and asymptomatic individuals irrespective of healthcare-seeking behavior. Our aim is to estimate the incidence of travel-acquired AGE due to norovirus and to characterize the burden of disease among international travelers from the United States and Europe.We describe a prospective cohort study implemented in five US and European sites to estimate the role of AGE due to norovirus among adult international

2018 BMC Infectious Diseases PubMed

6. Review: chronic and persistent diarrhea with a focus in the returning traveler (Full text)

Review: chronic and persistent diarrhea with a focus in the returning traveler Travelers' diarrhea is a common malady afflicting up to 50% of travelers after a 2-week travel period. An appreciable percentage of these cases will become persistent or chronic. We summarized the published literature reporting persistent/chronic diarrhea in travelers elucidating current understanding of disease incidence, etiology and regional variability.We searched electronic databases (Medline, Embase (...) heterogeneity statistics, graphically represented with Forest plots.We identified 19 studies meeting the inclusion criteria (all published after 1999). 18 studies reported upon the incidence of persistent/chronic diarrhea as a syndromic diagnosis in returning travelers; one study reported adequate denominator data from which to assess pathogen specific etiology. Giardiasis comprise an appreicaible percentage of infectious mediated persistent/chronic diarrhea in returning travelers. The overall estimate

2017 Tropical diseases, travel medicine and vaccines PubMed

7. Emerging concepts in the diagnosis, treatment, and prevention of travelers' diarrhea. (PubMed)

Emerging concepts in the diagnosis, treatment, and prevention of travelers' diarrhea. Traveller's diarrhea, though not life-threatening. is often a vexing problem, which impacts overall function of the traveller while on holiday. Increasing data is available regarding molecular diagnostic techniques, which may help obtain an early etiologic diagnosis. Use of antibiotics for traveller's diarrhea is controversial in this era of multidrug resistance and microbiome disruption.Travel to the tropics (...) promotes gut colonization with drug-resistant bacteria and this risk increases after treatment with antibiotics, leading to potential ecological impacts in the country of residence.Traveller's diarrhea is common and can impact a traveller's itinerary leading to significant inconvenience, and occasional longer term sequelae. Though bacterial causes predominate, recommended treatment is conservative in mild-to-moderate cases. Molecular techniques for early diagnosis of traveller's diarrhea may help

2019 Current Opinion in Infectious Diseases

8. Travelers' Diarrhea and Other Gastrointestinal Symptoms Among Boston-Area International Travelers. (Full text)

Travelers' Diarrhea and Other Gastrointestinal Symptoms Among Boston-Area International Travelers. AbstractThis prospective cohort study describes travelers' diarrhea (TD) and non-TD gastrointestinal (GI) symptoms among international travelers from the Boston area, the association of TD with traveler characteristics and dietary practices, use of prescribed antidiarrheal medications, and the impact of TD and non-TD GI symptoms on planned activities during and after travel. We included adults who (...) received a pre-travel consultation at three Boston-area travel clinics and who completed a three-part survey: pre-travel, during travel, and post-travel (2-4 weeks after return). TD was defined as self-reported diarrhea with or without nausea/vomiting, abdominal pain, or fever. Demographic and travel characteristics were evaluated by χ2 test for categorical and Wilcoxon rank-sum test for continuous variables. Analysis of dietary practices used logistic generalized estimating equation models or logistic

2017 American Journal of Tropical Medicine & Hygiene PubMed

9. Case-Case Analysis Using 7 Years of Travelers' Diarrhea Surveillance Data: Preventive and Travel Medicine Applications in Cusco, Peru. (Full text)

Case-Case Analysis Using 7 Years of Travelers' Diarrhea Surveillance Data: Preventive and Travel Medicine Applications in Cusco, Peru. AbstractIn Cusco, Peru, and South America in general, there is a dearth of travelers' diarrhea (TD) data concerning the clinical features associated with enteropathogen-specific infections and destination-specific risk behaviors. Understanding these factors would allow travel medicine providers to tailor interventions to patients' risk profiles and travel (...) destination. To characterize TD etiology, evaluate region-specific TD risk factors, and examine relationships between preventive recommendations and risk-taking behaviors among medium- to long-term travelers' from high-income countries, we conducted this case-case analysis using 7 years of prospective surveillance data from adult travelers' presenting with TD to a physician in Cusco. At the time of enrollment, participants provided a stool sample and answered survey questions about demographics, risk

2017 American Journal of Tropical Medicine & Hygiene PubMed

10. AGA Clinical Practice Guidelines on the Laboratory Evaluation of Functional Diarrhea and Diarrhea-Predominant Irritable Bowel Syndrome in Adults (IBS-D)

of at least 4 weeks duration. This would exclude those patients with bloody diarrhea; diarrhea with signs of fat malabsorption; presentations with alarm features, such as weight loss, anemia, and hypoalbuminemia; those patients with a family history of inflammatory bowel disease (IBD), colon cancer, or celiac disease; and those with a travel history to regions with recognized specific diarrhea-related pathogens. This guideline was developed using a process outlined elsewhere. x 1 American (...) either detection of Giardia antigens or polymerase chain reaction for the Giardia small subunit ribosomal RNA. Because treatments are straightforward, there is little risk in utilizing these tests in evaluation of chronic watery diarrhea. Recommendation 4: In patients presenting with chronic diarrhea with no travel history to or recent immigration from high-risk areas, the AGA suggests against testing for ova and parasites (other than Giardia ). Conditional recommendation: low-quality evidence

2019 American Gastroenterological Association Institute

11. Travelers' diarrhea in Thailand: a quantitative analysis using TaqMan® Array Card. (Full text)

Travelers' diarrhea in Thailand: a quantitative analysis using TaqMan® Array Card. Travelers' diarrhea (TD) is a common illness experienced by travelers from developed countries who visit developing countries. Recent questionnaire-based surveillance studies showed that approximately 6%-16% of travelers experienced TD while visiting Thailand; however, a majority of TD information was limited mainly to US military populations.A TD surveillance study was conducted at Bumrungrad International (...) by the diarrheagenic Escherichia coli and norovirus GII. These agents had significant pathogen-disease associations as well as high attributable fractions among diarrheal cases. A wide range of pathogen loads for Campylobacter spp. was associated with TD, while heat-labile toxin enterotoxigenic Escherichia coli was associated with an increased pathogen load. Most cases were associated with inflammatory diarrhea, while Campylobacter spp. and Shigella spp. were associated with dysentery.A pan-molecular diagnostic

2018 Clinical Infectious Diseases PubMed

12. Use of a multiplex DNA extraction PCR in the identification of pathogens in travelers' diarrhea. (Full text)

Use of a multiplex DNA extraction PCR in the identification of pathogens in travelers' diarrhea. Diarrhea is one of the most common ailments afflicting travelers with attack rates of 30-40% for medium to high-risk destinations. As travelers' diarrhea (TD) is syndromic and caused by a wide range of pathogens, including bacteria, parasites and viruses, multiplex deoxyribonucleic acid (DNA) extraction polymerase chain reaction (PCR) technology can be useful for determining the etiology of TD (...) by specific region.Stool analysis by DNA extraction PCR was obtained in 388 post-travel patients. Three hundred and twenty-seven of these had diarrhea or other enteric symptoms. Sixty-one travelers presented with enteric symptoms and were diagnosed with post infectious irritable bowel syndrome (PI-IBS) after stool analyses were negative. Of those with diarrhea or gastrointestinal (GI) symptoms and excluding those diagnosed with PI-IBS, 207 patients tested positive for at least 1 enteric pathogen (63.4

2018 Journal of Travel Medicine PubMed

13. Emergence of resistance to quinolones and β-lactam antibiotics in enteroaggregative and enterotoxigenic <i>Escherichia coli</i> causing traveler's diarrhea. (PubMed)

Emergence of resistance to quinolones and β-lactam antibiotics in enteroaggregative and enterotoxigenic Escherichia coli causing traveler's diarrhea. The objective of this study was to assess the antimicrobial resistance of enteroaggregative Escherichia coli (EAEC) and enterotoxigenic E. coli (ETEC) strains causing traveler's diarrhea (TD) and to investigate the molecular characterization of antimicrobial resistance genes to third-generation cephalosporins, cephamycins, and quinolones (...) to quinolones of EAEC and ETEC strains causing TD has significantly increased over the last decades, and high percentages have been found especially in patients traveling to India and sub-Saharan Africa. Sequence type 38 (ST38) and ST131, carrying the blaCTX-M-15 and blaCTX-M-27 genes, respectively, are highly prevalent among extended-spectrum β-lactamase (ESBL)-producing EAEC and ETEC strains. The cephamycinase ACT-20 is described in the present study for the first time in EAEC and ETEC strains causing TD

2018 Antimicrobial Agents and Chemotherapy

14. Schistosomiasis in a returning international traveler with cyclic fevers and diarrhea (Full text)

Schistosomiasis in a returning international traveler with cyclic fevers and diarrhea 29449243 2018 11 13 1715-5258 64 2 2018 Feb Canadian family physician Medecin de famille canadien Can Fam Physician Schistosomiasis in a returning international traveler with cyclic fevers and diarrhea. 123-126 Greer Emily E Family physician with Clinica Family Health Services in Boulder, Colo. Singh Kabir Harricharan KH Family physician with the Family Practice Center in Newport, Tenn. Blake Gregory G

2018 Canadian Family Physician PubMed

15. Bismuth Subsalicylate's Role in the Prevention of Travelers' Diarrhea

Bismuth Subsalicylate's Role in the Prevention of Travelers' Diarrhea Bismuth Subsalicylate's Role in the Prevention of Travelers' Diarrhea - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Bismuth (...) Subsalicylate's Role in the Prevention of Travelers' Diarrhea The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03535272 Recruitment Status : Recruiting First Posted : May 24, 2018 Last Update Posted : May 25, 2018 See Sponsor

2018 Clinical Trials

16. Rifamycin SV-MMX® for treatment of travelers' diarrhea: equally effective as ciprofloxacin and not associated with the acquisition of multi-drug resistant bacteria. (Full text)

Rifamycin SV-MMX® for treatment of travelers' diarrhea: equally effective as ciprofloxacin and not associated with the acquisition of multi-drug resistant bacteria. The novel oral antibiotic formulation Rifamycin SV-MMX®, with a targeted delivery to the distal small bowel and colon, was superior to placebo in treating travellers' diarrhea (TD) in a previous study. Thus, a study was designed to compare this poorly absorbed antibiotic with the systemic agent ciprofloxacin.In a randomized double

2018 Journal of Travel Medicine PubMed

17. Effectiveness of rifaximin and fluoroquinolones in preventing travelers' diarrhea (TD): a systematic review and meta-analysis

Effectiveness of rifaximin and fluoroquinolones in preventing travelers' diarrhea (TD): a systematic review and meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2012 DARE.

18. Trial Evaluating Ambulatory Therapy of Travelers' Diarrhea (TrEAT TD) Study: A Randomized Controlled Trial Comparing 3 Single-Dose Antibiotic Regimens With Loperamide. (Full text)

Trial Evaluating Ambulatory Therapy of Travelers' Diarrhea (TrEAT TD) Study: A Randomized Controlled Trial Comparing 3 Single-Dose Antibiotic Regimens With Loperamide. Recommended treatment for travelers' diarrhea includes the combination of an antibiotic, usually a fluoroquinolone or azithromycin, and loperamide for rapid resolution of symptoms. However, adverse events, postdose nausea with high-dose azithromycin, effectiveness of single-dose rifaximin, and emerging resistance to front-line (...) agents are evidence gaps underlying current recommendations.A randomized, double-blind trial was conducted in 4 countries (Afghanistan, Djibouti, Kenya, and Honduras) between September 2012 and July 2015. US and UK service members with acute watery diarrhea were randomized and received single-dose azithromycin (500 mg; 106 persons), levofloxacin (500 mg; 111 persons), or rifaximin (1650 mg; 107 persons), in combination with loperamide (labeled dosing). The efficacy outcomes included clinical cure

2017 Clinical Infectious Diseases PubMed

19. Guidelines for the prevention and treatment of travelers' diarrhea: a graded expert panel report. (Full text)

Guidelines for the prevention and treatment of travelers' diarrhea: a graded expert panel report. : Travelers' diarrhea causes significant morbidity including some sequelae, lost travel time and opportunity cost to both travelers and countries receiving travelers. Effective prevention and treatment are needed to reduce these negative impacts.: This critical appraisal of the literature and expert consensus guideline development effort asked several key questions related to antibiotic and non (...) -antibiotic prophylaxis and treatment, utility of available diagnostics, impact of multi-drug resistant (MDR) colonization associated with travel and travelers' diarrhea, and how our understanding of the gastrointestinal microbiome should influence current practice and future research. Studies related to these key clinical areas were assessed for relevance and quality. Based on this critical appraisal, guidelines were developed and voted on using current standards for clinical guideline development

2017 Journal of Travel Medicine PubMed

20. New molecular diagnostic tools in traveller's diarrhea. (Full text)

New molecular diagnostic tools in traveller's diarrhea. Traveller's diarrhea can be caused by bacteria, protozoa, helminths and viruses. Globally, the most common causes of traveller's diarrhea are two pathotypes of Escherichia coli (enterotoxigenic and enteroaggregative) and Shigella, although there are significant variations according to the geographic area visited. While traveller's diarrhea is usually a mild, self-limiting disease, half of the travellers with traveller's diarrhea have some (...) limitation in their activities during the journey and up to 10% present persistent diarrhea or other complications, making microbiological diagnosis necessary. The aim of this article is to describe the application of new molecular diagnostic tools mainly based on multiplex PCR, including their advantages and disadvantages as well as the current gaps that requiring further study.© International Society of Travel Medicine, 2016. Published by Oxford University Press. All rights reserved. For Permissions

2017 Journal of Travel Medicine PubMed

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