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Travelers Diarrhea Prophylaxis

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1. Summary of the Committee to Advise on Tropical Medicine and Travel (CATMAT) statement on travellers' diarrhea

. Prevention of traveler's diarrhea by the tablet form of Bismuth subsalicylate. Antimicrob Agents Chemother. 1986;29(4):625-7. Footnote 24 Plourde PJ. Travellers' diarrhea in children. Paediatrics & Child Health. 2003;8(2):99. Footnote 25 Johnson P, Ericsson C, Morgan D, DuPont H, Cabada F. Lack of emergence of resistant fecal flora during successful prophylaxis of traveler's diarrhea with norfloxacin. Antimicrob Agents Chemother. 1986;30(5):671-4. Footnote 26 Heck JE, Staneck JL, Cohen MB, Weckbach LS (...) , Giannella RA, Hawkins J, et al. Prevention of travelers' diarrhea: Ciprofloxacin versus trimethoprim/sulfamethoxazole in adult volunteers working in Latin America and the Caribbean. J Travel Med. 1994;1(3):136-42. Footnote 27 Scott DA, Haberberger RL, Thornton SA, Hyams KC. Norfloxacin for the prophylaxis of travelers' diarrhea in US military personnel. Am J Trop Med Hyg. 1990;42(2):160-4. Footnote 28 Wiström J, Norrby SR, Burman LG, Lundholm R, Jellheden B, Englund G. Norfloxacin versus placebo

2015 CPG Infobase

2. Traveler's Diarrhea Prophylaxis

Traveler's Diarrhea Prophylaxis Travelers Diarrhea Prophylaxis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Traveler's Diarrhea (...) Prophylaxis Traveler's Diarrhea Prophylaxis Aka: Traveler's Diarrhea Prophylaxis , Prophylaxis of Traveler's Diarrhea , Prevention of Traveler's Diarrhea , Traveler's Diarrhea Prevention II. Prevention: Traveler's Diarrhea Rule 1: "Boil it, Cook it, Peel it or Forget it" Preparing your own food ensures safety (avoid food prepared by street vendors) Dry foods (e.g. breads, chips) are typically safe Exposures to avoid Avoid raw, unpeeled vegetables, lettucs, tomatoes Avoid pre-peeled fruit Avoid tap water

2018 FP Notebook

3. A review of antibiotic prophylaxis for traveler’s diarrhea: past to present (PubMed)

A review of antibiotic prophylaxis for traveler’s diarrhea: past to present As there is rapid increase in international travel to tropical and subtropical countries, there will likely be more people exposed to diarrheal pathogens in these moderate to high risk areas and subsequent increased concern for traveler's diarrhea. The disease may appear as a mild clinical syndrome, yet a more debilitating presentation can lead to itinerary changes and hospitalization. As bacterial etiologies (...) are the most common causative agents of TD, the use of antibiotic prophylaxis to prevent TD has been reported among travelers for several years. The most common type of antibiotic used for TD has changed over 50 years, depending on many influencing factors. The use of antibiotic prophylaxis for TD prevention in travelers is still controversial, mainly because of difficulties balancing the risks and benefits. Many factors, such as emerging drug resistance, side effects, cost and risk behavior need

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2018 Tropical diseases, travel medicine and vaccines

4. Bismuth Subsalicylate's Role in the Prevention of Travelers' Diarrhea

Bismuth Subsalicylate's Role in the Prevention of Travelers' Diarrhea Bismuth Subsalicylate's Role in the Prevention of Travelers' Diarrhea - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Bismuth (...) Subsalicylate's Role in the Prevention of Travelers' Diarrhea The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03535272 Recruitment Status : Recruiting First Posted : May 24, 2018 Last Update Posted : May 25, 2018 See Sponsor

2018 Clinical Trials

5. Guidelines for the prevention and treatment of travelers' diarrhea: a graded expert panel report. (PubMed)

-antibiotic prophylaxis and treatment, utility of available diagnostics, impact of multi-drug resistant (MDR) colonization associated with travel and travelers' diarrhea, and how our understanding of the gastrointestinal microbiome should influence current practice and future research. Studies related to these key clinical areas were assessed for relevance and quality. Based on this critical appraisal, guidelines were developed and voted on using current standards for clinical guideline development (...) methodology.: New definitions for severity of travelers' diarrhea were developed. A total of 20 graded recommendations on the topics of prophylaxis, diagnosis, therapy and follow-up were developed. In addition, three non-graded consensus-based statements were adopted.: Prevention and treatment of travelers' diarrhea requires action at the provider, traveler and research community levels. Strong evidence supports the effectiveness of antimicrobial therapy in most cases of moderate to severe travelers

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2017 Journal of Travel Medicine

6. Medications for the prevention and treatment of travellers' diarrhea. (PubMed)

Medications for the prevention and treatment of travellers' diarrhea. . Travellers' diarrhea (TD) remains one of the most common illnesses encountered by travellers to less developed areas of the world. Because bacterial pathogens such as enterotoxigenic Escherichia coli (ETEC), enteroaggregative E. coli , Campylobacter spp. and Shigella spp. are the most frequent causes, antibiotics have been useful in both prevention and treatment of TD.Results of trials that assessed the use of medications (...) for the prevention and treatment of TD were identified through PubMed and MEDLINE searches using search terms 'travellers' diarrhea', 'prevention' and 'treatment'. References of articles were also screened for additional relevant studies.Prevention of TD with antibiotics has been recommended only under special circumstances. Doxycycline, trimethoprim-sulfamethoxazole, fluoroquinolones and rifaximin have been used for prevention, but at present the first three antibiotics may have limited use secondary

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2017 Journal of Travel Medicine

7. Clinical Trial of CBS-2004 in Prevention of Travelers' Diarrhea

with study drug and placebo during the period of prophylaxis and through the last clinic visit. [ Time Frame: 7 weeks ] To assess the effectiveness of CBS 2004 by evaluating the development of traveler's diarrhea (TD) with CBS-2004 versus placebo based on time to first unformed stool associated with a TD episode [ Time Frame: 7 weeks ] Secondary Outcome Measures : Assess the number of work days lost due to diarrhea [ Time Frame: 7 weeks ] Assess percentages of subjects requiring treatment for diarrhea (...) Clinical Trial of CBS-2004 in Prevention of Travelers' Diarrhea Clinical Trial of CBS-2004 in Prevention of Travelers' Diarrhea - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Clinical Trial of CBS-2004

2016 Clinical Trials

8. Diarrhoea - prevention and advice for travellers

and sanitation. Advice should be offered regarding self-management and when to seek medical advice if they develop diarrhoea during their travels. For people at high risk of travellers' diarrhoea: The importance of personal hygiene, food hygiene, and safe drinking water should be emphasized. Warn about the risk of waterborne infection and avoidance of contaminated recreational water. Antibiotic prophylaxis or 'stand-by' antibiotic treatment may be appropriate for certain high-risk travellers. Specialist (...) advice should be sought if antibiotic prophylaxis or 'stand-by' treatment is being considered. Advice should be given about managing travellers' diarrhoea while travelling: Most episodes are short-lived and self-limiting, lasting a few days. The person could consider purchasing sachets of oral rehydration salt before travelling. During an episode of diarrhoea, it is important to prevent dehydration — particularly for young children, pregnant women, elderly people, and those with pre-existing illness

2019 NICE Clinical Knowledge Summaries

9. Antimicrobial Prophylaxis Adult Patients With Cancer-Related Immunosuppression

role; speaker's bureau; research funding; patents, royalties, other intellectual property; expert testimony; travel, accommodations, expenses; and other relationships. In accordance with the Policy, the majority of the members of the Expert Panel did not disclose any relationships constituting a conflict under the Policy. RECOMMENDATIONS Section: provides a summary of antimicrobial prophylaxis recommendations. CLINICAL QUESTION 1 Antibacterial Prophylaxis. Does antibacterial prophylaxis (...) Antimicrobial Prophylaxis Adult Patients With Cancer-Related Immunosuppression Antimicrobial Prophylaxis for Adult Patients With Cancer-Related Immunosuppression: ASCO and IDSA Clinical Practice Guideline Update | Journal of Clinical Oncology Search in: Menu Article Tools ASCO SPECIAL ARTICLE Article Tools OPTIONS & TOOLS COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.18.00374 Journal of Clinical Oncology - published online before print September 4, 2018

2018 Infectious Diseases Society of America

10. Antimicrobial Prophylaxis for Adult Patients with Cancer-Related Immunosuppression

role; speaker's bureau; research funding; patents, royalties, other intellectual property; expert testimony; travel, accommodations, expenses; and other relationships. In accordance with the Policy, the majority of the members of the Expert Panel did not disclose any relationships constituting a conflict under the Policy. RECOMMENDATIONS Section: provides a summary of antimicrobial prophylaxis recommendations. CLINICAL QUESTION 1 Antibacterial Prophylaxis. Does antibacterial prophylaxis (...) Antimicrobial Prophylaxis for Adult Patients with Cancer-Related Immunosuppression Antimicrobial Prophylaxis for Adult Patients With Cancer-Related Immunosuppression: ASCO and IDSA Clinical Practice Guideline Update | Journal of Clinical Oncology Search in: Menu Article Tools ASCO SPECIAL ARTICLE Article Tools OPTIONS & TOOLS COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.18.00374 Journal of Clinical Oncology - published online before print September 4, 2018

2018 American Society of Clinical Oncology Guidelines

11. Traveler's Diarrhea Prophylaxis

Traveler's Diarrhea Prophylaxis Travelers Diarrhea Prophylaxis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Traveler's Diarrhea (...) Prophylaxis Traveler's Diarrhea Prophylaxis Aka: Traveler's Diarrhea Prophylaxis , Prophylaxis of Traveler's Diarrhea , Prevention of Traveler's Diarrhea , Traveler's Diarrhea Prevention II. Prevention: Traveler's Diarrhea Rule 1: "Boil it, Cook it, Peel it or Forget it" Preparing your own food ensures safety (avoid food prepared by street vendors) Dry foods (e.g. breads, chips) are typically safe Exposures to avoid Avoid raw, unpeeled vegetables, lettucs, tomatoes Avoid pre-peeled fruit Avoid tap water

2015 FP Notebook

12. Trial Evaluating Chemoprophylaxis Against Travelers' Diarrhea

Trial Evaluating Chemoprophylaxis Against Travelers' Diarrhea Trial Evaluating Chemoprophylaxis Against Travelers' Diarrhea - Prevent TD - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Trial Evaluating (...) Chemoprophylaxis Against Travelers' Diarrhea - Prevent TD The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02498301 Recruitment Status : Recruiting First Posted : July 15, 2015 Last Update Posted : January 21, 2019 See Sponsor

2015 Clinical Trials

13. An update on travelers' diarrhea. (PubMed)

, prevention, and treatment of travelers' diarrhea.Most causes of travelers' diarrhea remain bacterial, but newly recognized pathogens are emerging. Patient-related and travel-related factors affect disease development risk and should guide prophylaxis and treatment. Although specific vaccines are being developed, they have not yet had a major impact on travelers' diarrhea, and understanding their roles and limitations is especially important. Prophylaxis and treatment of populations at risk (children (...) An update on travelers' diarrhea. Travelers' diarrhea, affecting millions of travelers every year globally, continues to be a leading cause of morbidity despite advances in vaccination, prevention, and treatment. Complications of travelers' diarrhea often present to gastroenterologists and some patients followed by gastroenterologists are at higher risk of developing travelers' diarrhea. This review will provide an update on recent progress made in the epidemiology, pathogenesis, diagnosis

2015 Current opinion in gastroenterology

14. Travelers' health problems and behavior: prospective study with post-travel follow-up. (PubMed)

population consisted of 460 subjects, 79 % of whom reported illness during travel or on arrival: 69 % had travelers' diarrhea (TD), 17 % skin problems, 17 % fever, 12 % vomiting, 8 % respiratory tract infection, 4 % urinary tract infection, 2 % ear infection, 4 % gastrointestinal complaints other than TD or vomiting, and 4 % other symptoms. Of all subjects, 10 % consulted a doctor and 0.7 % were hospitalized; 18 % took antimicrobials, with TD as the most common indication (64 %). Ongoing symptoms were (...) reported by 25 % of all travelers upon return home. During the three-week follow-up (return rate 51 %), 32 % of respondents developed new-onset symptoms, 20 % visited a doctor and 1.7 % were hospitalized. Factors predisposing to health problems were identified by multivariable analysis: certain regions (Southern Asia, South-Eastern Asia, and Eastern Africa), female gender, young age, and long travel duration.Despite proper preventive measures like vaccinations, malaria prophylaxis, and travel advice

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2016 BMC Infectious Diseases

15. Standard pre-travel consultation versus shorter consultation combined with smartphone support: a randomized controlled trial. (PubMed)

of diarrhea (4), malaria prophylaxis (2), and altitude sickness prophylaxis (5). Other consultations consisted mainly of reassurances of worried travelers and provision of data. Knowledge about travel-related risks was higher in the control group before travelling (8.86 ± 1.12 versus 8.34 ± 1.32, p = 0.014), and there was a trend towards higher levels of knowledge also during the trip (8.29 ± 1.35 versus 7.89 ± 1.39 , p = 0.06). Travelers' satisfaction before and during the trip was similar in both groups (...) Standard pre-travel consultation versus shorter consultation combined with smartphone support: a randomized controlled trial. Immediate and long-term recall of a pretravel consultation are suboptimal. We aimed to assess the role of online consultation for travelers.We randomized travelers into two study groups. In the intervention arm, each traveler was given a short pre-travel consultation of 8-12 minutes, combined with the option of smartphone support before and during the trip

2019 Journal of Travel Medicine Controlled trial quality: uncertain

16. Hyperimmune bovine colostral anti-CS17 antibodies protect against enterotoxigenic Escherichia coli diarrhea in a randomized, doubled-blind, placebo-controlled human infection model. (PubMed)

Hyperimmune bovine colostral anti-CS17 antibodies protect against enterotoxigenic Escherichia coli diarrhea in a randomized, doubled-blind, placebo-controlled human infection model. Enterotoxigenic Escherichia coli (ETEC) commonly cause diarrhea in children living in developing countries and in travelers to those regions. ETEC are characterized by colonization factors (CFs) that mediate intestinal adherence. We assessed if bovine colostral IgG (bIgG) antibodies against a CF, CS17, or antibodies (...) oral prophylaxis and 35 were challenged with ETEC. While 50.0% of the placebo recipients had watery diarrhea, none of the subjects receiving anti-CS17 had diarrhea (P = .01). In contrast, diarrhea rates between placebo and anti-CsbD recipients (41.7%) were comparable (P = 1.0).This is the first study to demonstrate anti-CS17 antibodies provide significant protection against ETEC expressing CS17. More research is needed to better understand why anti-CsbD was not comparably efficacious. Clinical

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2019 Journal of Infectious Diseases Controlled trial quality: uncertain

17. Statement on older travellers

; completion of full vaccination series for travel and for routine childhood immunizations Malaria prophylaxis: drug, dose, schedule, adherence, duration, side effects Other prophylaxis: drug, dose, schedule, adherence, duration, side effects Other personal protective measures: standby treatment of malaria / travellersdiarrhea; bednets; clothing; insecticide use Air transportation preparations: deep vein thrombosis (DVT) prophylaxis, medications for jet lag Environmental risk preparations: sun, extreme (...) in the post-travel setting, and may herald serious and life-threatening illness, the most important of which is malaria. All febrile patients or patients complaining of fever should therefore be asked about recent travel. While fever in the returning traveller may be due to benign self-limited infections, such as common agents of travellersdiarrhea, or typical cosmopolitan causes unrelated to travel, it must be initially construed as a medical emergency , and warrants prompt and thorough evaluation

2011 CPG Infobase

18. Fever in the returning international traveller: Initial assessment guidelines

versus injectable formulation if applicable; completion of full vaccination series for travel and for routine childhood immunizations Malaria prophylaxis : drug, dose, schedule, adherence, duration, side effects Other prophylaxis : drug, dose, schedule, adherence, duration, side effects Other personal protective measures: standby treatment of malaria / travellersdiarrhea; bednets; clothing; insecticide use Air transportation preparations : deep vein thrombosis (DVT) prophylaxis, medications for jet (...) : crowding; use of animals such as camels, elephants C. Exposure history* Street foods / Local water (enteric fever, travellersdiarrhea) Arthropod bites (malaria, dengue, chikungunya, arboviruses, Rickettsia , African trypanosomiasis) Uncooked meat / unpasteurized dairy (trichinosis, brucellosis, toxoplasmosis) Blood and body fluid exposure : sexual encounters, tattoos, piercings, injections including immunizations, intravenous (IV) drug use, and rabies post-exposure prophylaxis (PEP) (human

2011 CPG Infobase

19. Nationwide survey of the role of travel medicine in primary care in Germany. (PubMed)

% provided medical pretravel advice or post-travel counseling (13.2 patients/month). The most common topics in pretravel consultation were immunizations (95%), malaria chemoprophylaxis (94%), advice on exposure prophylaxis (41%), and advice on protection from sexually transmitted infections (STIs) (43%). GPs frequently advised certain patient groups (e.g., cardiovascular patients 68%, pregnant women 20%). Travelers' diarrhea was the most common topic in post-travel consultation (89%), followed by fever (...) (38%). Of the GPs, 25% cooperated regularly with institutions with special expertise in travel medicine or tropical diseases. Sixty-four percent had received some training in travel medicine, and 86% stated a need for additional training. In the multivariate analysis, independent determinants for advice on exposure prophylaxis and STI risks included special training in travel medicine, use of country-specific information sources, and location of the practice in the former West Germany and urban

2017 Journal of Travel Medicine

20. Risk and spectrum of diseases in travelers to popular tourist destinations. (PubMed)

recommended dietary restrictions. Among travelers visiting malaria-endemic areas, 20% did not carry any antimalarial drugs with them, not continuous chemoprophylaxis or standby medication.Because of the rising travel activity, especially to tropical countries, the importance of qualified pretravel advice consultation is increasing. To improve the travelers' health, attention needs to be paid to individual risk factors, the prevention and therapy of travelers' diarrhea, malaria prophylaxis, management (...) Risk and spectrum of diseases in travelers to popular tourist destinations. Traveling to tropical regions is related to increased health risks. Travelers' diarrhea is the most frequent health problem, but the range of travel-related diseases also includes potential life-threatening diseases such as malaria. The actual risk of European travelers acquiring specific infectious diseases and other hazards in the tropics is to a large extent unknown and is therefore often adopted from

2017 Journal of Travel Medicine

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