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Travelers Diarrhea

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1. Rifamycin (Aemcolo) - To treat travelers? diarrhea

Rifamycin (Aemcolo) - To treat travelers? diarrhea Drug Approval Package: AEMCOLO (rifamycin) U.S. Department of Health and Human Services Search FDA Submit search Drug Approval Package: AEMCOLO (rifamycin) Company:Cosmo Technologies, Inc. Application Number: 210910Orig 1 Approval Date: 11/16/2018 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. FDA Approval Letter and Labeling (PDF) (PDF) FDA Application Review Files (PDF) (PDF

2019 FDA - Drug Approval Package

3. Summary of the Committee to Advise on Tropical Medicine and Travel (CATMAT) statement on travellers' diarrhea

Summary of the Committee to Advise on Tropical Medicine and Travel (CATMAT) statement on travellers' diarrhea CATMAT Statement: TravelersDiarrhea - Canada.ca Language selection Search Search Canada.ca Search Menu Main Menu You are here: CATMAT Statement: TravelersDiarrhea Published by: Issue: Date published: November 5, 2015 ISSN: 1481-8531 Submit a manuscript About CCDR Browse Volume 41-11, November 5, 2015: Foodborne Illness Advisory Committee Statement Summary of the Committee to Advise (...) on Tropical Medicine and Travel (CATMAT) Statement on TravelersDiarrhea Libman M 1 , on behalf of CATMAT* Affiliation 1 Division of Infectious Disease, McGill University Health Centre, Montréal, QC Correspondence DOI https://doi.org/10.14745/ccdr.v41i11a03 Abstract Background: Most travellers' diarrhea (TD) infections occur during travel to low- and middle-income countries. Type of travel, duration of stay, age of traveller and presence of certain medical conditions are important factors to consider

2015 CPG Infobase

4. Despite Predominance of Uropathogenic/Extraintestinal Pathotypes Among Travel-acquired Extended-spectrum β-Lactamase-producing Escherichia coli, the Most Commonly Associated Clinical Manifestation Is Travelers' Diarrhea. (PubMed)

Despite Predominance of Uropathogenic/Extraintestinal Pathotypes Among Travel-acquired Extended-spectrum β-Lactamase-producing Escherichia coli, the Most Commonly Associated Clinical Manifestation Is Travelers' Diarrhea. One-third of the 100 million travelers to the tropics annually acquire extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-PE), with undefined clinical consequences.Symptoms suggesting Enterobacteriaceae infections were recorded prospectively among 430 (...) ESBL-PE carriers, manifestations of Enterobacteriaceae infection included travelers' diarrhea (TD) (75/90 subjects) and urinary tract infection (UTI) (3/90). The carriers had 96 ESBL-producing E. coli isolates, 51% exhibiting a molecular pathotype: 13 (14%) were DEC (10 EAEC, 2 EPEC, 1 ETEC) (12 associated with TD) and 39 (41%) ExPEC/UPEC (none associated with UTI). Of ESBL-PE, 3 (3%) were ExPEC/UPEC-EAEC hybrids (2 associated with diarrhea, none with UTI). Potential ESBL-PE infections were

2019 Clinical Infectious Diseases

5. Estimating the incidence of norovirus acute gastroenteritis among US and European international travelers to areas of moderate to high risk of traveler's diarrhea: a prospective cohort study protocol. (PubMed)

Estimating the incidence of norovirus acute gastroenteritis among US and European international travelers to areas of moderate to high risk of traveler's diarrhea: a prospective cohort study protocol. Acute gastroenteritis (AGE) is the leading cause of illness among returning travelers seeking medical care. Multiple types of enteric pathogens can cause travel-acquired AGE and, while bacterial pathogens have a predominant role, the importance of viruses, such as norovirus, is increasingly (...) recognized. There is a lack of information on travel-acquired norovirus incidence among symptomatic and asymptomatic individuals irrespective of healthcare-seeking behavior. Our aim is to estimate the incidence of travel-acquired AGE due to norovirus and to characterize the burden of disease among international travelers from the United States and Europe.We describe a prospective cohort study implemented in five US and European sites to estimate the role of AGE due to norovirus among adult international

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2018 BMC Infectious Diseases

6. Review: chronic and persistent diarrhea with a focus in the returning traveler (PubMed)

Review: chronic and persistent diarrhea with a focus in the returning traveler Travelers' diarrhea is a common malady afflicting up to 50% of travelers after a 2-week travel period. An appreciable percentage of these cases will become persistent or chronic. We summarized the published literature reporting persistent/chronic diarrhea in travelers elucidating current understanding of disease incidence, etiology and regional variability.We searched electronic databases (Medline, Embase (...) heterogeneity statistics, graphically represented with Forest plots.We identified 19 studies meeting the inclusion criteria (all published after 1999). 18 studies reported upon the incidence of persistent/chronic diarrhea as a syndromic diagnosis in returning travelers; one study reported adequate denominator data from which to assess pathogen specific etiology. Giardiasis comprise an appreicaible percentage of infectious mediated persistent/chronic diarrhea in returning travelers. The overall estimate

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2017 Tropical diseases, travel medicine and vaccines

7. Emerging concepts in the diagnosis, treatment, and prevention of travelers' diarrhea. (PubMed)

Emerging concepts in the diagnosis, treatment, and prevention of travelers' diarrhea. Traveller's diarrhea, though not life-threatening. is often a vexing problem, which impacts overall function of the traveller while on holiday. Increasing data is available regarding molecular diagnostic techniques, which may help obtain an early etiologic diagnosis. Use of antibiotics for traveller's diarrhea is controversial in this era of multidrug resistance and microbiome disruption.Travel to the tropics (...) promotes gut colonization with drug-resistant bacteria and this risk increases after treatment with antibiotics, leading to potential ecological impacts in the country of residence.Traveller's diarrhea is common and can impact a traveller's itinerary leading to significant inconvenience, and occasional longer term sequelae. Though bacterial causes predominate, recommended treatment is conservative in mild-to-moderate cases. Molecular techniques for early diagnosis of traveller's diarrhea may help

2019 Current Opinion in Infectious Diseases

8. AGA Clinical Practice Guidelines on the Laboratory Evaluation of Functional Diarrhea and Diarrhea-Predominant Irritable Bowel Syndrome in Adults (IBS-D)

of at least 4 weeks duration. This would exclude those patients with bloody diarrhea; diarrhea with signs of fat malabsorption; presentations with alarm features, such as weight loss, anemia, and hypoalbuminemia; those patients with a family history of inflammatory bowel disease (IBD), colon cancer, or celiac disease; and those with a travel history to regions with recognized specific diarrhea-related pathogens. This guideline was developed using a process outlined elsewhere. x 1 American (...) either detection of Giardia antigens or polymerase chain reaction for the Giardia small subunit ribosomal RNA. Because treatments are straightforward, there is little risk in utilizing these tests in evaluation of chronic watery diarrhea. Recommendation 4: In patients presenting with chronic diarrhea with no travel history to or recent immigration from high-risk areas, the AGA suggests against testing for ova and parasites (other than Giardia ). Conditional recommendation: low-quality evidence

2019 American Gastroenterological Association Institute

9. Case-Case Analysis Using 7 Years of Travelers' Diarrhea Surveillance Data: Preventive and Travel Medicine Applications in Cusco, Peru. (PubMed)

Case-Case Analysis Using 7 Years of Travelers' Diarrhea Surveillance Data: Preventive and Travel Medicine Applications in Cusco, Peru. AbstractIn Cusco, Peru, and South America in general, there is a dearth of travelers' diarrhea (TD) data concerning the clinical features associated with enteropathogen-specific infections and destination-specific risk behaviors. Understanding these factors would allow travel medicine providers to tailor interventions to patients' risk profiles and travel (...) destination. To characterize TD etiology, evaluate region-specific TD risk factors, and examine relationships between preventive recommendations and risk-taking behaviors among medium- to long-term travelers' from high-income countries, we conducted this case-case analysis using 7 years of prospective surveillance data from adult travelers' presenting with TD to a physician in Cusco. At the time of enrollment, participants provided a stool sample and answered survey questions about demographics, risk

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2017 American Journal of Tropical Medicine & Hygiene

10. Travelers' Diarrhea and Other Gastrointestinal Symptoms Among Boston-Area International Travelers. (PubMed)

Travelers' Diarrhea and Other Gastrointestinal Symptoms Among Boston-Area International Travelers. AbstractThis prospective cohort study describes travelers' diarrhea (TD) and non-TD gastrointestinal (GI) symptoms among international travelers from the Boston area, the association of TD with traveler characteristics and dietary practices, use of prescribed antidiarrheal medications, and the impact of TD and non-TD GI symptoms on planned activities during and after travel. We included adults who (...) received a pre-travel consultation at three Boston-area travel clinics and who completed a three-part survey: pre-travel, during travel, and post-travel (2-4 weeks after return). TD was defined as self-reported diarrhea with or without nausea/vomiting, abdominal pain, or fever. Demographic and travel characteristics were evaluated by χ2 test for categorical and Wilcoxon rank-sum test for continuous variables. Analysis of dietary practices used logistic generalized estimating equation models or logistic

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2017 American Journal of Tropical Medicine & Hygiene

11. Effectiveness of rifaximin and fluoroquinolones in preventing travelers' diarrhea (TD): a systematic review and meta-analysis

Effectiveness of rifaximin and fluoroquinolones in preventing travelers' diarrhea (TD): a systematic review and meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2012 DARE.

12. Cyclospora cayetanensis in a patient with travelers' diarrhea: case report and review. (PubMed)

Cyclospora cayetanensis in a patient with travelers' diarrhea: case report and review. In recent years, several studies have shown that Cyclospora cayetanensis is a worldwide intestinal pathogen, and it has been implicated in a number of sporadic cases and epidemic outbreaks of diarrheal illness in several endemic areas. The parasite is associated with prolonged and relapsing watery diarrhea in immunocompetent persons, as well as in AIDS patients. Most reports of Cyclospora infection concern (...) travelers visiting endemic countries. In European countries, a few cases of Cyclospora cayetanensis infection have been reported, and almost all of them were observed in persons after foreign travel.

2017 Journal of Travel Medicine

13. Correlation between adherence to precautions issued by the WHO and diarrhea among long-term travelers to India. (PubMed)

Correlation between adherence to precautions issued by the WHO and diarrhea among long-term travelers to India. Travelers' diarrhea is the most common infectious disease afflicting travelers to developing countries. Most studies investigating the benefits of recommendations regarding the consumption of food and water have focused on short-term travelers. We investigated the benefits of adherence to the precautions from the World Health Organization (WHO) among long-term travelers.We asked 140 (...) incidental travelers in India traveling for at least 2 months to complete a questionnaire about their adherence to the WHO precautions and the occurrence of diarrhea. Adherence was graded on a scale of 1 to 6 (least to most).The mean age of the 114 travelers whose questionnaires were eligible was 26.6 +/- 5.7 years, and the median duration of their trip was 5 months. None of them adhered strictly to the entire set of rules. The mean individual adherence was 3.4 (range 1.2-5.8). The vast majority

2017 Journal of Travel Medicine

14. Dientamoeba fragilis as a cause of travelers' diarrhea: report of seven cases. (PubMed)

Dientamoeba fragilis as a cause of travelers' diarrhea: report of seven cases. Dientamoeba fragilis is a pathogenic trichomonad parasite that causes gastrointestinal disease in humans. We report seven cases of travelers' diarrhea caused by D fragilis in patients who had traveled to overseas destinations within Asia or the Pacific which occurred over an 8-month period. Patients presented with diarrhea lasting from 5 days to over 4 weeks. Dientamoeba fragilis should be considered as a cause (...) of diarrhea in returning travelers.

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2017 Journal of Travel Medicine

15. A report on a cluster of travelers' diarrhea among Cambodian students visiting Thailand. (PubMed)

A report on a cluster of travelers' diarrhea among Cambodian students visiting Thailand. Travelers' diarrhea is an important gastrointestinal disorder in developing countries.A cluster of travelers' diarrhea among Cambodian students visiting Thailand is described in this article.Nine cases of travelers' diarrhea were identified. These cases were among Cambodian students visiting Thailand under an exchange program. All presented with symptoms of diarrhea and nausea, and all improved within (...) that day.The prevention of gastrointestinal illness as well as recommendations for hygienic precautions for travelers who plan to visit tropical Asia, where the high prevalence of gastrointestinal disorder is documented, are important. In addition, a similar practice among local travelers within tropical Asia is also necessary.

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2017 Journal of Travel Medicine

16. Bismuth Subsalicylate's Role in the Prevention of Travelers' Diarrhea

Bismuth Subsalicylate's Role in the Prevention of Travelers' Diarrhea Bismuth Subsalicylate's Role in the Prevention of Travelers' Diarrhea - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Bismuth (...) Subsalicylate's Role in the Prevention of Travelers' Diarrhea The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03535272 Recruitment Status : Recruiting First Posted : May 24, 2018 Last Update Posted : May 25, 2018 See Sponsor

2018 Clinical Trials

17. Management of travelers' diarrhea by local physicians in tropical and subtropical countries--a questionnaire survey. (PubMed)

Management of travelers' diarrhea by local physicians in tropical and subtropical countries--a questionnaire survey. There is an ongoing debate as to whether patients with travelers' diarrhea (TD) should self-medicate with a travel kit in developing countries or whether they should consult local doctors. Thus, we have analyzed TD management conducted by local health professionals.Practicing physicians recommended to tourists in Goa (India), Mombasa (Kenya), and Phuket (Thailand) were invited (...) of the different patients. Mainly practitioners who owned a clinic would have hospitalized patients with TD.Many physicians in destination countries treat TD patients similarly to the treatments prescribed in the "Western world." A minority uses obsolete antimicrobials. Polypharmacy and the high rate of invasive procedures with a theoretical risk of nosocomial infection are of concern. Training initiatives for both local physicians and travelers might be beneficial, and the guidelines should be based

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2017 Journal of Travel Medicine

18. Travelers' diarrhea in children visiting tropical countries. (PubMed)

Travelers' diarrhea in children visiting tropical countries. We studied a group of 174 Portuguese children (aged 2 mo-16 y) who mostly traveled to tropical Portuguese-speaking countries and found an attack rate of 21.8% for travelers' diarrhea, much lower than previously described. We also showed that African rate analysis by region may hide significant differences between countries.

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2017 Journal of Travel Medicine

19. Schistosomiasis in a returning international traveler with cyclic fevers and diarrhea (PubMed)

Schistosomiasis in a returning international traveler with cyclic fevers and diarrhea 29449243 2018 11 13 1715-5258 64 2 2018 Feb Canadian family physician Medecin de famille canadien Can Fam Physician Schistosomiasis in a returning international traveler with cyclic fevers and diarrhea. 123-126 Greer Emily E Family physician with Clinica Family Health Services in Boulder, Colo. Singh Kabir Harricharan KH Family physician with the Family Practice Center in Newport, Tenn. Blake Gregory G

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2018 Canadian Family Physician

20. Emergence of resistance to quinolones and β-lactam antibiotics in enteroaggregative and enterotoxigenic <i>Escherichia coli</i> causing traveler's diarrhea. (PubMed)

Emergence of resistance to quinolones and β-lactam antibiotics in enteroaggregative and enterotoxigenic Escherichia coli causing traveler's diarrhea. The objective of this study was to assess the antimicrobial resistance of enteroaggregative Escherichia coli (EAEC) and enterotoxigenic E. coli (ETEC) strains causing traveler's diarrhea (TD) and to investigate the molecular characterization of antimicrobial resistance genes to third-generation cephalosporins, cephamycins, and quinolones (...) to quinolones of EAEC and ETEC strains causing TD has significantly increased over the last decades, and high percentages have been found especially in patients traveling to India and sub-Saharan Africa. Sequence type 38 (ST38) and ST131, carrying the blaCTX-M-15 and blaCTX-M-27 genes, respectively, are highly prevalent among extended-spectrum β-lactamase (ESBL)-producing EAEC and ETEC strains. The cephamycinase ACT-20 is described in the present study for the first time in EAEC and ETEC strains causing TD

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2018 Antimicrobial Agents and Chemotherapy

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