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21. From the Past to the Present: Insurer Coverage Frameworks for Next-Generation Tumor Sequencing. Full Text available with Trip Pro

From the Past to the Present: Insurer Coverage Frameworks for Next-Generation Tumor Sequencing. Next-generation sequencing promises major advancements in precision medicine but faces considerable challenges with insurance coverage. These challenges are especially important to address in oncology in which next-generation tumor sequencing (NGTS) holds a particular promise, guiding the use of life-saving or life-prolonging therapies. Payers' coverage decision making on NGTS is challenging because (...) this revolutionary technology pushes the very boundaries of the underlying framework used in coverage decisions. Some experts have called for the adaptation of the coverage framework to make it better equipped for assessing NGTS. Medicare's recent decision to cover NGTS makes this topic particularly urgent to examine. In this article, we discussed the previously proposed approaches for adaptation of the NGTS coverage framework, highlighted their innovations, and outlined remaining gaps in their ability to assess

2018 Value in Health

22. Evidence for the Use of Acupuncture in Treating Parkinson's Disease: Update of Information From the Past 5 Years, a Mini Review of the Literature Full Text available with Trip Pro

and meta-analyses have been conducted to evaluate the efficacy of acupuncture. The aim of our current study is to provide updated information in brief on this topic. In this study, we analyzed and summarized seven RCTs and four meta-analyses. Although all included studies were not of high quality, we found that there has been a tremendous progress in acupuncture research in treating Parkinson's disease (PD) during the past 5 years, based on our experience and insights into the behavioral assessments (...) Evidence for the Use of Acupuncture in Treating Parkinson's Disease: Update of Information From the Past 5 Years, a Mini Review of the Literature Acupuncture is an alternative therapy for Parkinson's disease (PD), but its efficacy and safety are controversial. Our previous study, which reviewed the literature from 1974 to 2012, could not find enough evidence from rigorously designed randomized, controlled trials (RCTs) to make a conclusion about the efficacy of acupuncture. Recently, more RCTs

2018 Frontiers in neurology

23. The Evolving Presence of Women in Academic Plastic Surgery: A Study of the Past 40 Years. (Abstract)

The Evolving Presence of Women in Academic Plastic Surgery: A Study of the Past 40 Years. Among surgical subspecialties, plastic surgery holds the highest percentage of women, and, the female contingent of board-certified plastic surgeons and trainees has grown steadily. However, their academic impact has been underestimated. We present the academic footprint of female plastic surgeons over the past 40 years.A list of female plastic surgeons currently active at, and retired from, Accreditation (...) Council for Graduate Medical Education-accredited plastic surgery residency programs was compiled. Each surgeon was searched on PubMed to gather their total number of publications, journals, and topics of research after completion of training. Date of publication and 5-year impact factor for each journal were recorded. Publications were organized into 10-year periods (1976 to 1985, 1986 to 1995, 1996 to 2005, and 2006 to 2016).One hundred fifty-five currently active and 80 retired academic female

2018 Plastic and reconstructive surgery

24. 2% Chlorhexidine (CHX) vs CaOH2 (CH) Calcium Hydroxide Paste as an Intracanal Medicament

) as Intracanal Medicament in Endodontic Emergencies and to Compare Its Use and Effectiveness With CaOH2 (CH) Calcium Hydroxide Paste Estimated Study Start Date : November 1, 2018 Estimated Primary Completion Date : October 31, 2021 Estimated Study Completion Date : November 9, 2021 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Clorhexidine 2% Chlorhexidine Drug: Chlorhexidine 2% Chorhexidine (...) 2% Chlorhexidine (CHX) vs CaOH2 (CH) Calcium Hydroxide Paste as an Intracanal Medicament 2% Chlorhexidine (CHX) vs CaOH2 (CH) Calcium Hydroxide Paste as an Intracanal Medicament - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2018 Clinical Trials

25. Cellular Immunotherapy for Immune Tolerance in Past Recipients of HLA Zero-mismatch, Living Donor Kidney Transplants

-label Trial to Assess the Safety and Efficacy of Cellular Immunotherapy With MDR-103 for Induction of Mixed Chimerism and Immune Tolerance in Past Recipients of HLA Zero-mismatch, Living Donor Kidney Transplants Actual Study Start Date : August 31, 2018 Estimated Primary Completion Date : October 2019 Estimated Study Completion Date : April 2021 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental (...) Cellular Immunotherapy for Immune Tolerance in Past Recipients of HLA Zero-mismatch, Living Donor Kidney Transplants Cellular Immunotherapy for Immune Tolerance in Past Recipients of HLA Zero-mismatch, Living Donor Kidney Transplants - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2018 Clinical Trials

26. How Our Cognition Shapes and Is Shaped by Technology: A Common Framework for Understanding Human Tool-Use Interactions in the Past, Present, and Future Full Text available with Trip Pro

How Our Cognition Shapes and Is Shaped by Technology: A Common Framework for Understanding Human Tool-Use Interactions in the Past, Present, and Future Over the evolution, humans have constantly developed and improved their technologies. This evolution began with the use of physical tools, those tools that increase our sensorimotor abilities (e.g., first stone tools, modern knives, hammers, pencils). Although we still use some of these tools, we also employ in daily life more sophisticated (...) tools for which we do not systematically understand the underlying physical principles (e.g., computers, cars). Current research is also turned toward the development of brain-computer interfaces directly linking our brain activity to machines (i.e., symbiotic tools). The ultimate goal of research on this topic is to identify the key cognitive processes involved in these different modes of interaction. As a primary step to fulfill this goal, we offer a first attempt at a common framework, based

2018 Frontiers in psychology

27. Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy. Full Text available with Trip Pro

Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy. Bcr-Abl inhibitors paved the way of targeted therapy epoch. Imatinib was the first tyrosine kinase inhibitor to be discovered with high specificity for Bcr-Abl protein resulting from t(9, 22)-derived Philadelphia chromosome. Although the specific targeting of that oncoprotein, several Bcr-Abl-dependent and Bcr-Abl-independent mechanisms of resistance to imatinib arose after becoming first-line (...) therapy in chronic myelogenous leukemia (CML) treatment.Consequently, new specific drugs, namely dasatinib, nilotinib, bosutinib, and ponatinib, were rationally designed and approved for clinic to override resistances. Imatinib fine mechanisms of action had been elucidated to rationally develop those second- and third-generation inhibitors. Crystallographic and structure-activity relationship analysis, jointly to clinical data, were pivotal to shed light on this topic. More recently, preclinical

2018 Journal of hematology & oncology

28. Photo-Activated Disinfection Versus Triple-Antibiotic Paste for Management of Necrotic Young Permanent Anterior Teeth

: Double (Participant, Outcomes Assessor) Primary Purpose: Treatment Official Title: Evaluation of Post-Operative Pain After Regenerative Endodontic Using Photo-Activated Oral Disinfection Versus Triple-Antibiotic Paste for Management of Necrotic Young Permanent Anterior Teeth Actual Study Start Date : October 15, 2016 Estimated Primary Completion Date : December 15, 2018 Estimated Study Completion Date : April 15, 2019 Resource links provided by the National Library of Medicine related topics: Arms (...) Photo-Activated Disinfection Versus Triple-Antibiotic Paste for Management of Necrotic Young Permanent Anterior Teeth Photo-Activated Disinfection Versus Triple-Antibiotic Paste for Management of Necrotic Young Permanent Anterior Teeth - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2018 Clinical Trials

29. Effects of Benzocaine 20% Topical Anesthetic and no Topical Agent on Pain Perception During Intra-oral Injections

Effects of Benzocaine 20% Topical Anesthetic and no Topical Agent on Pain Perception During Intra-oral Injections Effects of Benzocaine 20% Topical Anesthetic and no Topical Agent on Pain Perception During Intra-oral Injections - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Effects of Benzocaine 20% Topical Anesthetic and no Topical Agent on Pain Perception During Intra-oral Injections The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03261115 Recruitment Status : Completed First Posted : August 24, 2017

2017 Clinical Trials

30. In a Patient Requiring Endodontic Therapy, The use of N2-Sargenti Paste Proves to be Much More Cytotoxic in Comparison with Other Endodontic Sealers

In a Patient Requiring Endodontic Therapy, The use of N2-Sargenti Paste Proves to be Much More Cytotoxic in Comparison with Other Endodontic Sealers UTCAT2676, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title In a Patient Requiring Endodontic Therapy, The use of N2-Sargenti Paste Proves to be Much More Cytotoxic in Comparison with Other Endodontic Sealers Clinical Question In a patient requiring endodontic therapy, does (...) , and being a laboratory study there was no need for patient compliance and followup. There was no evidence of recall bias or competing interests for any of the studies. Perspective: The successful use of Sargenti paste is largely influenced by technique. It appears that this paste’s improper delivery is the reason for it’s lack of support in the American dental world. It was also for this reason that the studies and reports about this topic were confined to experimental analyses on cell cultures rather

2014 UTHSCSA Dental School CAT Library

31. Topics in Integrative, Alternative, and Complementary Therapies (PDQ®): Patient Version

Topics in Integrative, Alternative, and Complementary Therapies (PDQ®): Patient Version Topics in Integrative, Alternative, and Complementary Therapies (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf Warning: The NCBI web site requires JavaScript to function. Search database Search term Search NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health. PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002 (...) -. PDQ Cancer Information Summaries [Internet]. Bethesda (MD): ; 2002-. Search term Topics in Integrative, Alternative, and Complementary Therapies (PDQ®) Patient Version PDQ Integrative, Alternative, and Complementary Therapies Editorial Board . Published online: November 2, 2018. Created: March 29, 2013 . This PDQ cancer information summary has current information about the complementary and alternative therapies found in other PDQ summaries and NCI Fact Sheets. It is meant to inform and help

2018 PDQ - NCI's Comprehensive Cancer Database

32. Insect Bites - Guidelines for Prescribing Topical Hydrocortisone

Insect Bites - Guidelines for Prescribing Topical Hydrocortisone Insect Bites - Guidelines for Prescribing Topical Hydrocortisone - medSask Home - College of Pharmacy and Nutrition - University of Saskatchewan Toggle Menu Search the U of S Search Insect Bites - Guidelines for Prescribing Topical Hydrocortisone Insect bites which cause local inflammatory reactions are puncture wounds from insects whose saliva contains concentrated irritant substances such as anticoagulants and enzymes. Symptoms (...) are likely to be on the lower legs and around the waist, often occurring in clusters Bedbugs may bite in clusters, usually around the head and neck Ticks attach themselves as a person brushes past leaves and grasses the ticks are on. Once in contact, they may move to a warm and moist location such as the armpit, groin, back of the knee or hairline, where they burrow into the host's skin and feed off their blood Black fly bites are often along the hairline and around the ears Sand fly bites are usually

2016 medSask

33. Sports psychology: past and future directions

Sports psychology: past and future directions The importance of being a sports psychiatrist | BJSM blog - social media's leading SEM voice by By Dr Thomas McCabe and Dr Allan Johnston Over the past year, we’ve seen the media explode over mental health disorders within sporting circles (1-3). High profile athletes describe their struggles and point out the lack of provision for diagnosis and treatment. Campaigns at various levels – local, club, governmental and international continually (...) psychiatrist’s competencies were not clearly defined until the RCPsych Specialist Interest Group (SEPSIG) broached the topic and formed core competencies. Requirements are currently the same as any psychiatrist, but with a sporting insight into both individual and team culture. The sport psychiatrist should have sound diagnostic and reformulation ability, combined with effective communication skills and interpretative analysis of information gleaned. Awareness of the complexities of medicinal prescription

2018 British Journal of Sports Medicine Blog

34. Drinking alcohol key to living past 90? What you need to know

interventions. And those will be still be alive on the site for a couple of years. 6093 Posts Menu February 21, 2018 Drinking alcohol key to living past 90? What you need to know Posted By Categories , Tags , , Michael Joyce is a writer-producer at HealthNewsReview.org and tweets as Here’s a recipe for misinformation: Take two topics well known to generate clicks: alcohol and longevity. Find a study that suggests alcohol increases longevity. Fail to mention the study is observational but still emphasize (...) Drinking alcohol key to living past 90? What you need to know Drinking alcohol key to living past 90? What you need to know - HealthNewsReview.org Note to our followers: Our nearly 13-year run of daily publication of new content on HealthNewsReview.org came to a close at the end of 2018. Publisher Gary Schwitzer and other contributors may post new articles periodically. But all of the 6,000+ articles we have published contain lessons to help you improve your critical thinking about health care

2018 HealthNewsReview

35. Effect of Topical Anesthetics on Vaccine

to receive the vaccine but are anxious about needle stick pain may refuse the vaccine. If used according to manufacturer recommendation, topical anesthetics are effective in decreasing pain as the needle penetrates the skin and reduces muscle spasm associated with this pain (PHAC, 2014). The use of topical anesthetics is often presented as an option to reduce pain associated with vaccine injection. In the past some nurses delayed immunization when the student had applied a topical anesthetic (...) Effect of Topical Anesthetics on Vaccine i Effect of Topical Anesthetics on Vaccine: A Focused Practice Question Augustina Nagberi-Asseez, Analyst, Research and Policy Sarah Loseth, Supervisor Loretta Rowan, Manager November 2015 ii Table of Contents 1 Issue 1 2 Context 1 3 Literature Review Question 2 4 Literature Search 2 5 Relevance Assessment 3 5.1 Inclusion Criteria: 3 5.2 Exclusion Criteria: 3 6 Results of the Search 4 7 Critical Appraisal 4 8 Description of Included Studies 5 9 Synthesis

2015 Peel Health Library

36. Opioids, Driving and Implications for Youth (Topic Summary)

Opioids, Driving and Implications for Youth (Topic Summary) www.ccsa.ca • www.cclt.ca Canadian Centre on Substance Abuse • Centre canadien de lutte contre les toxicomanies Page 1 Topic Summary Opioids, Driving and Implications for Youth This summary is one in a series of four that briefly review the current state of scientific evidence on the effects of various classes of drugs on driving behaviour, while highlighting implications for young drivers. This summary focuses on opioids (also (...) % reported past-year use of opioid pain relievers; 15.9% of those aged 20–24 reported past-year use. Prescription opioids are used in the medical treatment of acute and chronic moderate to severe pain, and are also effective cough suppressants and anti-diarrheal medications. While prescription opioids are prescribed for therapeutic purposes, they have the potential to be misused because of their psychoactive properties. These medications are often misused for feelings of well-being or euphoria (i.e

2015 Canadian Centre on Substance Abuse

37. Sedatives, Driving and Implications for Youth (Topic Summary)

Sedatives, Driving and Implications for Youth (Topic Summary) www.ccsa.ca • www.cclt.ca Canadian Centre on Substance Abuse • Centre canadien de lutte contre les toxicomanies Page 1 Topic Summary Sedatives, Driving and Implications for Youth This summary is one in a series of four that briefly review the current state of scientific evidence on the effects of various classes of drugs on driving behaviour, while highlighting implications for young drivers. This summary focuses on sedatives (...) , 3.6% of Canadian youth aged 15–19 reported having used sedatives in the previous 12 months; among those aged 20–24, 4.7% reported past-year use. Prescription sedatives are commonly used for the management of anxiety, insomnia and seizure disorders. While these medications are prescribed for therapeutic purposes, they have the potential to be misused because of their psychoactive properties. In 2012–2013, 1.1% of Canadian students in grades 6 to 12 reported past-year use of sedatives to get high

2015 Canadian Centre on Substance Abuse

38. Topical heat for bluebottle stings

Topical heat for bluebottle stings RACGP - Topical heat for bluebottle stings Search Become a student member today for free and be part of the RACGP community A career in general practice Starting the GP journey Enrolments for the 2019.1 OSCE FRACGP exams closing 29 March 2019 Fellowship FRACGP exams Research Practice Experience Program is a self-directed education program designed to support non vocationally registered doctors on their pathway to RACGP Fellowship Fellowship International (...) for educators Regional Training The Red Book provides the general practice team with guidance on opportunistic and proactive preventive care Guidelines by topic Key RACGP guidelines Handbook of Non-Drug Interventions (HANDI) Send a request for information, a loan, literature search, journal article, book chapter and one-on-one remote training sessions Library services eBooks Journals Databases and resources Subject portals Download the Standards for general practice (5th edition) - a benchmark for quality

2013 Handbook of Non-Drug interventions (HANDI)

39. The effects of topical antibiotics on eradication and acquisition of third-generation cephalosporin and carbapenem-resistant Gram-negative bacteria in ICU patients; a post hoc analysis from a multicentre cluster-randomized trial. (Abstract)

The effects of topical antibiotics on eradication and acquisition of third-generation cephalosporin and carbapenem-resistant Gram-negative bacteria in ICU patients; a post hoc analysis from a multicentre cluster-randomized trial. The aim was to quantify the effects of selective digestive tract decontamination (SDD) consisting of a mouth paste and gastro-enteral suspension, selective oropharyngeal decontamination with a mouth paste (SOD) and 1-2% chlorhexidine (CHX) mouthwash on eradication

2019 Clinical Microbiology and Infection Controlled trial quality: uncertain

40. Use of Topical Intraocular Pressure-lowering Medications in the US Population: Results From the NHANES Study 1999 to 2014. (Abstract)

Use of Topical Intraocular Pressure-lowering Medications in the US Population: Results From the NHANES Study 1999 to 2014. We found no evidence of an increase in the number of Americans using topical intraocular pressure (IOP) medication or a number of drops used per patient from 1999 to 2014, although there were significant changes in the class of medications used.The purpose of this study was to determine changes in topical IOP-lowering medication use in the United States from 1999 to 2014 (...) .A series of 8 nationally representative, weighted cross-sectional surveys of United States residents were performed every 2 years from 1999 to 2014. On 2-year cycles, professional interviewers performed in-home interviews of a representative sample of the nation as part of the National Health and Nutrition Examination Survey study. Participants were asked, "In the past month, have you used or taken medication for which a prescription is needed?" Adults over age 40 who responded to this question were

2019 Journal of Glaucoma

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