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21. Evidence for the Use of Acupuncture in Treating Parkinson's Disease: Update of Information From the Past 5 Years, a Mini Review of the Literature (Full text)

and meta-analyses have been conducted to evaluate the efficacy of acupuncture. The aim of our current study is to provide updated information in brief on this topic. In this study, we analyzed and summarized seven RCTs and four meta-analyses. Although all included studies were not of high quality, we found that there has been a tremendous progress in acupuncture research in treating Parkinson's disease (PD) during the past 5 years, based on our experience and insights into the behavioral assessments (...) Evidence for the Use of Acupuncture in Treating Parkinson's Disease: Update of Information From the Past 5 Years, a Mini Review of the Literature Acupuncture is an alternative therapy for Parkinson's disease (PD), but its efficacy and safety are controversial. Our previous study, which reviewed the literature from 1974 to 2012, could not find enough evidence from rigorously designed randomized, controlled trials (RCTs) to make a conclusion about the efficacy of acupuncture. Recently, more RCTs

2018 Frontiers in neurology PubMed

22. Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy. (Full text)

Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy. Bcr-Abl inhibitors paved the way of targeted therapy epoch. Imatinib was the first tyrosine kinase inhibitor to be discovered with high specificity for Bcr-Abl protein resulting from t(9, 22)-derived Philadelphia chromosome. Although the specific targeting of that oncoprotein, several Bcr-Abl-dependent and Bcr-Abl-independent mechanisms of resistance to imatinib arose after becoming first-line (...) therapy in chronic myelogenous leukemia (CML) treatment.Consequently, new specific drugs, namely dasatinib, nilotinib, bosutinib, and ponatinib, were rationally designed and approved for clinic to override resistances. Imatinib fine mechanisms of action had been elucidated to rationally develop those second- and third-generation inhibitors. Crystallographic and structure-activity relationship analysis, jointly to clinical data, were pivotal to shed light on this topic. More recently, preclinical

2018 Journal of hematology & oncology PubMed

23. Cellular Immunotherapy for Immune Tolerance in Past Recipients of HLA Zero-mismatch, Living Donor Kidney Transplants

-label Trial to Assess the Safety and Efficacy of Cellular Immunotherapy With MDR-103 for Induction of Mixed Chimerism and Immune Tolerance in Past Recipients of HLA Zero-mismatch, Living Donor Kidney Transplants Actual Study Start Date : August 31, 2018 Estimated Primary Completion Date : October 2019 Estimated Study Completion Date : April 2021 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental (...) Cellular Immunotherapy for Immune Tolerance in Past Recipients of HLA Zero-mismatch, Living Donor Kidney Transplants Cellular Immunotherapy for Immune Tolerance in Past Recipients of HLA Zero-mismatch, Living Donor Kidney Transplants - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2018 Clinical Trials

24. Efficiency of Triple Antibiotic Paste, Ciprofloxacin/Propolis, Ciprofloxacin/Metronidazole, Propolis/Metronidazole Combinations on Revascularization Process of Immature Necrotic Maxillary Incisors of Patients 8-18 Years Old.

Primary Completion Date : October 1, 2017 Actual Study Completion Date : January 1, 2018 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Triple Antibiotic Paste (TAP) It consisted of Ciprofloxacin (Ciprocin 250 mg tablets; EPICO, Cairo, Egypt), Metronidazole (Flagyl 500 mg tablets; Sanofi Aventis Pharma, Cairo, Egypt), Doxycycline (Vibramycin 100 mg capsules; Pfizer, Cairo, Egypt). One (...) Efficiency of Triple Antibiotic Paste, Ciprofloxacin/Propolis, Ciprofloxacin/Metronidazole, Propolis/Metronidazole Combinations on Revascularization Process of Immature Necrotic Maxillary Incisors of Patients 8-18 Years Old. Efficiency of Triple Antibiotic Paste, Ciprofloxacin/Propolis, Ciprofloxacin/Metronidazole, Propolis/Metronidazole Combinations on Revascularization Process of Immature Necrotic Maxillary Incisors of Patients 8-18 Years Old. - Full Text View - ClinicalTrials.gov Hide

2018 Clinical Trials

25. 2% Chlorhexidine (CHX) vs CaOH2 (CH) Calcium Hydroxide Paste as an Intracanal Medicament

) as Intracanal Medicament in Endodontic Emergencies and to Compare Its Use and Effectiveness With CaOH2 (CH) Calcium Hydroxide Paste Estimated Study Start Date : November 1, 2018 Estimated Primary Completion Date : October 31, 2021 Estimated Study Completion Date : November 9, 2021 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Clorhexidine 2% Chlorhexidine Drug: Chlorhexidine 2% Chorhexidine (...) 2% Chlorhexidine (CHX) vs CaOH2 (CH) Calcium Hydroxide Paste as an Intracanal Medicament 2% Chlorhexidine (CHX) vs CaOH2 (CH) Calcium Hydroxide Paste as an Intracanal Medicament - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2018 Clinical Trials

26. Effects of an ER Beta Agonist (Lilly Compound LY500307) on Estradiol-Withdrawal-Induced Mood Symptoms in Women With Past Perimenopausal Depression

Effects of an ER Beta Agonist (Lilly Compound LY500307) on Estradiol-Withdrawal-Induced Mood Symptoms in Women With Past Perimenopausal Depression Effects of an ER Beta Agonist (Lilly Compound LY500307) on Estradiol-Withdrawal-Induced Mood Symptoms in Women With Past Perimenopausal Depression - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies (...) Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effects of an ER Beta Agonist (Lilly Compound LY500307) on Estradiol-Withdrawal-Induced Mood Symptoms in Women With Past Perimenopausal Depression The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies

2018 Clinical Trials

27. Update on Randomized Placebo-Controlled Trials in the Past Decade for Treatment of Major Depressive Disorder in Child and Adolescent Patients: A Systematic Review. (PubMed)

Update on Randomized Placebo-Controlled Trials in the Past Decade for Treatment of Major Depressive Disorder in Child and Adolescent Patients: A Systematic Review. Antidepressant treatment for major depressive disorder (MDD) has been a topic of continued interest with a number of placebo randomized-controlled trials (RCTs) being published in the past decade. We review the updated literature since the 2007 Bridge meta-analysis, and reassess safety data looking at signals of treatment-emergent (...) to support fluoxetine and escitalopram as first-line treatment and demonstrated effect to prevent relapse. Use of newer rating scales reveals similar rates of treatment-emergent suicidality in patients on antidepressants as placebo, in contrast to increased suicide signal suggested by past research using adverse events data. Antidepressant treatment is generally safe and well tolerated in this age group.

2018 Journal of Child and Adolescent Psychopharmacology

28. How Our Cognition Shapes and Is Shaped by Technology: A Common Framework for Understanding Human Tool-Use Interactions in the Past, Present, and Future (Full text)

How Our Cognition Shapes and Is Shaped by Technology: A Common Framework for Understanding Human Tool-Use Interactions in the Past, Present, and Future Over the evolution, humans have constantly developed and improved their technologies. This evolution began with the use of physical tools, those tools that increase our sensorimotor abilities (e.g., first stone tools, modern knives, hammers, pencils). Although we still use some of these tools, we also employ in daily life more sophisticated (...) tools for which we do not systematically understand the underlying physical principles (e.g., computers, cars). Current research is also turned toward the development of brain-computer interfaces directly linking our brain activity to machines (i.e., symbiotic tools). The ultimate goal of research on this topic is to identify the key cognitive processes involved in these different modes of interaction. As a primary step to fulfill this goal, we offer a first attempt at a common framework, based

2018 Frontiers in psychology PubMed

29. From the Past to the Present: Insurer Coverage Frameworks for Next-Generation Tumor Sequencing. (Full text)

From the Past to the Present: Insurer Coverage Frameworks for Next-Generation Tumor Sequencing. Next-generation sequencing promises major advancements in precision medicine but faces considerable challenges with insurance coverage. These challenges are especially important to address in oncology in which next-generation tumor sequencing (NGTS) holds a particular promise, guiding the use of life-saving or life-prolonging therapies. Payers' coverage decision making on NGTS is challenging because (...) this revolutionary technology pushes the very boundaries of the underlying framework used in coverage decisions. Some experts have called for the adaptation of the coverage framework to make it better equipped for assessing NGTS. Medicare's recent decision to cover NGTS makes this topic particularly urgent to examine. In this article, we discussed the previously proposed approaches for adaptation of the NGTS coverage framework, highlighted their innovations, and outlined remaining gaps in their ability to assess

2018 Value in Health PubMed

30. Contact Dermatitis in Atopic Dermatitis Children-Past, Present, and Future. (PubMed)

Contact Dermatitis in Atopic Dermatitis Children-Past, Present, and Future. Allergic contact dermatitis (ACD) used to be considered a rarity in children, but recently has been estimated to effect 4.4 million children in the USA alone, with a notable rise in investigative research in the field of pediatric ACD. Researchers have shown that patch testing is safe and effective in afflicted children and that those with atopic dermatitis (AD) have similar sensitization rates, although they have (...) a higher sensitization to certain allergens, thought to be related to the inflammatory (IL-4) milieu. Patch testing assessment guidelines in children include five key considerations: if a patient's dermatitis worsens, changes distribution, fails to improve with topical therapy, or immediately rebounds after removal of topical treatments; if a patient has a particular distribution of dermatitis; if a working patient has hand eczema that fails to improve with therapy; if the patient has AD that started

2018 Clinical Reviews in Allergy & Immunology

31. Role of Propolis Paste in Preventing Pain After Root Canal Treatment.

Intervention Model: Parallel Assignment Masking: Double (Participant, Investigator) Primary Purpose: Prevention Official Title: Effect of Propolis Paste as Intracanal Medicament on Post-Endodontic Pain: a Double-Blind Randomized Clinical Trial. Actual Study Start Date : November 16, 2017 Actual Primary Completion Date : April 24, 2018 Actual Study Completion Date : October 15, 2018 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm (...) Role of Propolis Paste in Preventing Pain After Root Canal Treatment. Role of Propolis Paste in Preventing Pain After Root Canal Treatment. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Role of Propolis

2018 Clinical Trials

32. The Evolving Presence of Women in Academic Plastic Surgery: A Study of the Past 40 Years. (PubMed)

The Evolving Presence of Women in Academic Plastic Surgery: A Study of the Past 40 Years. Among surgical subspecialties, plastic surgery holds the highest percentage of women, and, the female contingent of board-certified plastic surgeons and trainees has grown steadily. However, their academic impact has been underestimated. We present the academic footprint of female plastic surgeons over the past 40 years.A list of female plastic surgeons currently active at, and retired from, Accreditation (...) Council for Graduate Medical Education-accredited plastic surgery residency programs was compiled. Each surgeon was searched on PubMed to gather their total number of publications, journals, and topics of research after completion of training. Date of publication and 5-year impact factor for each journal were recorded. Publications were organized into 10-year periods (1976 to 1985, 1986 to 1995, 1996 to 2005, and 2006 to 2016).One hundred fifty-five currently active and 80 retired academic female

2018 Plastic and reconstructive surgery

33. Photo-Activated Disinfection Versus Triple-Antibiotic Paste for Management of Necrotic Young Permanent Anterior Teeth

: Double (Participant, Outcomes Assessor) Primary Purpose: Treatment Official Title: Evaluation of Post-Operative Pain After Regenerative Endodontic Using Photo-Activated Oral Disinfection Versus Triple-Antibiotic Paste for Management of Necrotic Young Permanent Anterior Teeth Actual Study Start Date : October 15, 2016 Estimated Primary Completion Date : December 15, 2018 Estimated Study Completion Date : April 15, 2019 Resource links provided by the National Library of Medicine related topics: Arms (...) Photo-Activated Disinfection Versus Triple-Antibiotic Paste for Management of Necrotic Young Permanent Anterior Teeth Photo-Activated Disinfection Versus Triple-Antibiotic Paste for Management of Necrotic Young Permanent Anterior Teeth - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2018 Clinical Trials

34. Topics in Integrative, Alternative, and Complementary Therapies (PDQ®): Patient Version

Topics in Integrative, Alternative, and Complementary Therapies (PDQ®): Patient Version Topics in Integrative, Alternative, and Complementary Therapies (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf Warning: The NCBI web site requires JavaScript to function. Search database Search term Search NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health. PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002 (...) -. PDQ Cancer Information Summaries [Internet]. Bethesda (MD): ; 2002-. Search term Topics in Integrative, Alternative, and Complementary Therapies (PDQ®) Patient Version PDQ Integrative, Alternative, and Complementary Therapies Editorial Board . Published online: November 2, 2018. Created: March 29, 2013 . This PDQ cancer information summary has current information about the complementary and alternative therapies found in other PDQ summaries and NCI Fact Sheets. It is meant to inform and help

2018 PDQ - NCI's Comprehensive Cancer Database

35. Caries prevention in young children: topical fluoride alone not sufficient suggests trial

Caries prevention in young children: topical fluoride alone not sufficient suggests trial Caries prevention in young children: topical fluoride alone not sufficient suggests trial - National Elf Service Search National Elf Service Search National Elf Service » » » » Caries prevention in young children: topical fluoride alone not sufficient suggests trial Apr 26 2017 Posted by Caries is the commonest childhood disease and untreated decay is present in a large proportion of children by the time (...) with no caries into dentine, past history of filings or extractions were randomised to either a preventive package of fluoride varnish (22,600 ppm of fluoride varnish applied to all primary teeth), fluoride toothpaste (50-mL tube of 1,450 ppm), toothbrush and standard dental health education or standard dental health education alone at six-monthly intervals. The primary outcome measure was conversion from caries-free to caries-active states (diagnosed at the caries into dentine level), and secondary out

2017 The Dental Elf

36. Topical Nitroglycerin for Peripheral Circulation and Wound Healing in the Elderly

with peripheral vascular disease Intervention Topical nitroglycerin (e.g., ointment, paste, patches) Comparator ? Placebo or no treatment ? No comparator Outcomes Q1: Clinical effectiveness: ? Benefits (e.g., increased circulation, wound healing) ? Harms (e.g., hypotension, falls, localized skin sensitivity) Q2: Evidence-based guidelines Study Designs Health technology assessments, systematic reviews, meta-analyses, randomized controlled trials, non-randomized studies, evidence-based guidelines RESULTS Rapid (...) Topical Nitroglycerin for Peripheral Circulation and Wound Healing in the Elderly Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. Rapid responses should

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

37. Political correctness and the taboo topics in medicine

Political correctness and the taboo topics in medicine Political correctness and the taboo topics in medicine Political correctness and the taboo topics in medicine | | February 24, 2019 1K Shares I write for several publications, and I’m always pitching to new venues. Recently I pitched an idea to an editor. I wanted to write about gun research from the perspective of a rural physician. In particular, I wanted to ask what might physicians say if researchers found answers that were (...) as: , Subscribe to KevinMD and never miss a story! Get free updates delivered free to your inbox. Subscribe Hire KevinMD to keynote your next event "Kevin's keynote presentation was perfect. Extremely rich in content, and a delivery that is world class." Related Posts More in Physician < Previous post Next post > Find jobs at Careers by KevinMD.com Search thousands of physician, PA, NP, and CRNA jobs now. × Political correctness and the taboo topics in medicine 12 comments Comments are moderated before

2019 KevinMD blog

38. Discussion of Potentially Sensitive Topics With Young People. (PubMed)

-Motivation-Behavioral Skills model. Those who had seen a regular health care provider in the past 2 years were asked about 11 specific topics recommended by national medical guidelines. Four multivariable regression models were used to identify independent predictors of discussions of (1) tobacco use, (2) drug and/or alcohol use, (3) sexually transmitted infections or HIV, and (4) the number of topics discussed.Fewer than half of young people reported having discussed 10 of 11 topics at their last visit (...) Discussion of Potentially Sensitive Topics With Young People. To identify modifiable factors that facilitate discussion of potentially sensitive topics between health care providers and young people at preventive service visits after Patient Protection and Affordable Care Act implementation.We used data from a national internet survey of adolescents and young adults (13-26 years old) in the United States. Questionnaire construction was guided by formative research and Fisher's Information

2019 Pediatrics

39. As renewed debate over health care reform begins to simmer in Washington, can journalists give the topic the attention it needs?

As renewed debate over health care reform begins to simmer in Washington, can journalists give the topic the attention it needs? As renewed debate over health care reform begins to simmer in Washington, can journalists give the topic the attention it needs? - HealthNewsReview.org Note to our followers: Our nearly 13-year run of daily publication of new content on HealthNewsReview.org came to a close at the end of 2018. Publisher Gary Schwitzer and other contributors may post new articles (...) periodically. But all of the 6,000+ articles we have published contain lessons to help you improve your critical thinking about health care interventions. And those will be still be alive on the site for a couple of years. 6093 Posts Menu December 21, 2018 As renewed debate over health care reform begins to simmer in Washington, can journalists give the topic the attention it needs? Posted By Categories Tags Trudy Lieberman is a veteran healthcare journalist and a regular contributor

2018 HealthNewsReview

40. Assessment of Topical Corticosteroid Prescribing, Counseling, and Communication Among Dermatologists and Pharmacists. (PubMed)

Assessment of Topical Corticosteroid Prescribing, Counseling, and Communication Among Dermatologists and Pharmacists. Topical corticosteroids (TCs) are common treatments for many dermatologic conditions. Anecdotal experience and literature suggest that dermatologists and pharmacists differ in their beliefs about TCs and approach to TC counseling, creating the opportunity for patient confusion.To examine interprofessional practice gaps between dermatologists and pharmacists with regard to how (...) -question survey recalling experiences with TC prescribing from the past year along with self-reported demographic information.Dermatologists' and pharmacists' self-reported counseling of patients regarding TC application, duration of use, and adverse effects; frequency of communication of changes to TC prescriptions and instructions; and demographic data were tabulated and compared.Of the 117 dermatologists, 52 (44.4%) completed and returned the survey; of the 2954 pharmacists, 111 (3.8%) returned

2019 JAMA dermatology (Chicago, Ill.)

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