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Topical Ointment

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161. Effect of Topical Garlic on Wound Healing and Scarring: A Clinical Trial. (Abstract)

Effect of Topical Garlic on Wound Healing and Scarring: A Clinical Trial. Historically, garlic containing compounds have been used on wounds to improve healing and ward off infection. Researchers have tested many of these ancient ointments, discovering that garlic is a common ingredient in those that are effective.To determine the efficacy of topical garlic on surgical wounds compared with Vaseline by analysis of visual analog scales and digital photograph analysis.Seventeen patients with 2 (...) skin excisions applied a 30% garlic ointment to one surgical wound and Vaseline to the other surgical wound twice daily. They were followed up at 2 weeks and 4 weeks post-op. Digital photographs were taken of the sites, and wound visual analog scales were filled out by the patient and the physician.Patients and the onsite physician stated the garlic site healed better in 59% and 65% of the wounds, respectively, at 2 weeks. At 4 weeks, the patients and the onsite physician stated the garlic site

2019 Dermatologic Surgery

162. Comparison of the safety and efficacy of topical Tacrolimus (0.03%) versus dexamethasone (0.05%) for subepithelial infiltrates after adenoviral conjunctivitis. Full Text available with Trip Pro

Comparison of the safety and efficacy of topical Tacrolimus (0.03%) versus dexamethasone (0.05%) for subepithelial infiltrates after adenoviral conjunctivitis. To compare the safety and efficacy of tacrolimus 0.03% ointment with dexamethasone 0.05% ointment for subepithelial infiltrates (SEIs) following adenoviral keratoconjunctivitis (AK).A randomized, double blind trial was done. Eligibility criteria was corrected distance visual acuity of 6/9 Snellen or worse for at least 4 weeks (...) with corneal SEIs following AK. The grading of SEIs was done on a scale of 0 to 3; 0, no infiltrates, 1 mild infiltration, 2 moderate infiltration and 3, severe infiltration. Consecutive patients with SEIs following AK were randomized to receive either topical tacrolimus 0.03% or dexamethasone 0.05% ointment twice daily for 6 months. Treatment was successful if there was reduction of SEIs and improvement in vision.A total of 45 patients each were assigned to the Tacro and Dexa groups, respectively

2019 Indian journal of ophthalmology Controlled trial quality: uncertain

163. CD101 Topical Compared With Oral Fluconazole for Acute Vulvovaginal Candidiasis: A Randomized Controlled Trial. (Abstract)

CD101 Topical Compared With Oral Fluconazole for Acute Vulvovaginal Candidiasis: A Randomized Controlled Trial. Vulvovaginal candidiasis (VVC) is an infection of the vagina's mucous membranes, caused by Candida albicans in more than 90% of acute VVC. Several topical and oral azole agents are available in a variety of formulations, and all seem to have similar effectiveness. Azoles are fungistatic, meaning that the fungi are inhibited from growth or replication but are not eradicated. Recurrent (...) infection and developing azole resistance demonstrate a significant need for alternative treatments.One hundred twenty-six women were randomized to 1 of the following 3 treatment cohorts: CD101 3% gel (n = 50) applied intravaginally on days 1 and 2, CD101 6% ointment (n = 50) applied intravaginally on day 1, or oral fluconazole 150 mg (n = 26) on day 1. Primary outcomes of clinical and mycological cure, as demonstrated by changes in the vaginal scores and mycological culture, were assessed on day 7 (±2

2019 Journal of lower genital tract disease Controlled trial quality: uncertain

164. Ozenoxacin Cream, 1% - Topical Treatment of Impetigo. (Abstract)

Department of Medicine, Baylor University Medical Center, Dallas, TX. Departments of Dermatology and Family Practice, University of Texas Southwestern Medical School, Dallas, TX. Dermatology Treatment and Research Center, Dallas, TX. eng Journal Article Randomized Controlled Trial 2017 02 01 United States Skinmed 101168327 1540-9740 0 Aminopyridines 0 Anti-Bacterial Agents 0 Ointments 0 Quinolones V0LH498RFO ozenoxacin IM Administration, Topical Adult Aminopyridines therapeutic use Anti-Bacterial Agents (...) Ozenoxacin Cream, 1% - Topical Treatment of Impetigo. 28270312 2019 07 08 2019 07 08 1540-9740 15 1 2017 Skinmed Skinmed Ozenoxacin Cream, 1% - Topical Treatment of Impetigo. 57-59 Gupta Aditya K AK Department of Medicine, University of Toronto School of Medicine, Toronto, Ontario, Canada, Dallas, TX; agupta@execulink.com. Mediprobe Research Inc., London, Ontario, Canada, Dallas, TX. Versteeg Sarah G SG Mediprobe Research Inc., London, Ontario, Canada, Dallas, TX. Abramovits William W

2019 Skinmed Controlled trial quality: uncertain

165. Topical estradiol increases epidermal thickness and dermal collagen of foreskin prior to hypospadia surgery - Randomized double blinded controlled trial. (Abstract)

effects in epidermal thickness and collagen distribution of estradiol compared to testosterone and placebo in skin of prepuce before hypospadia surgery.Patients were randomized into three groups according to the topical hormone used: TG: Testosterone ointment; EG: Estradiol ointment; CG: Neutral base ointment. Fragments of foreskin were excised, fixed and then sectioned for histology. For each sample, epidermal thickness and dermal collagen expression was measured by specific computer analysis, P (...) Topical estradiol increases epidermal thickness and dermal collagen of foreskin prior to hypospadia surgery - Randomized double blinded controlled trial. The use of preoperative topical testosterone stimulation prior to hypospadias correction aims to increase penile size and achieve better surgical results. Topical estradiol has been shown to improve the quality of skin in other sites, but its use in boys with hypospadia has not yet been elucidated.This study aims to evaluate the primary

2019 Journal of pediatric urology Controlled trial quality: uncertain

166. Topical Nifedipine for the Treatment of Pressure Ulcer: A Randomized, Placebo-Controlled Clinical Trial. (Abstract)

Topical Nifedipine for the Treatment of Pressure Ulcer: A Randomized, Placebo-Controlled Clinical Trial. Effect of nifedipine on pressure ulcer (PU) healing has not been evaluated in the human subjects yet.In this study, the effect of topical application of nifedipine 3% ointment on PU healing in critically ill patients was investigated.This was a randomized, double-blind, placebo-controlled clinical.In this study, 200 patients with stage I or II PU according to 2-digit Stirling Pressure Ulcer (...) Severity Scale were randomized to receive topical nifedipine 3% ointment or placebo twice daily for 14 days. Changes in the size and stage of the ulcers were considered as primary outcome of the study. The stage of the ulcers at baseline and on day 7 and day 14 of study was determined by using 2-digit stirling scale. In addition, the surface area of the wounds was estimated by multiplying width by length.In total, 83 patients in each group completed the study. The groups were matched for the baseline

2019 American journal of therapeutics Controlled trial quality: predicted high

167. Comparison of topical treatment methods used in recurrent anterior epistaxis: a randomized clinical trial: [[pt]]Comparação de métodos de tratamento tópico utilizados na epistaxe anterior recorrente: ensaio clínico randomizado. Full Text available with Trip Pro

aimed to compare the clinical efficacy of topical antiseptic ointment, topical decongestant ointment and chemical cauterization treatments, which are frequently used in recurrent anterior epistaxis, both singly and in combination.Between August 2017 and February 2018, 137 patients who were diagnosed with recurrent anterior epistaxis were randomly divided into 5 groups. group I received topical antiseptic ointment, group II received topical decongestant ointment, group III received chemical (...) Comparison of topical treatment methods used in recurrent anterior epistaxis: a randomized clinical trial: [[pt]]Comparação de métodos de tratamento tópico utilizados na epistaxe anterior recorrente: ensaio clínico randomizado. Recurrent epistaxis is a common medical problem faced by ENT specialists, emergency physicians, and pediatricians. The facts that many treatment modalities are being searched and no single treatment method is universally accepted yet support this information.We

2019 Brazilian journal of otorhinolaryngology Controlled trial quality: uncertain

168. Efficacy and safety of topical delgocitinib in patients with chronic hand eczema: data from a randomised, double-blind, vehicle-controlled Phase 2a study. Full Text available with Trip Pro

Efficacy and safety of topical delgocitinib in patients with chronic hand eczema: data from a randomised, double-blind, vehicle-controlled Phase 2a study. Management of chronic hand eczema (CHE) remains a challenge; effective topical treatment is still limited to corticosteroids.In this vehicle-controlled study, the efficacy/safety of a novel, pan-JAK inhibitor (delgocitinib) were assessed in patients with CHE.In this randomised, double-blind, Phase 2a study, patients with CHE received (...) delgocitinib ointment 30 mg/g or vehicle ointment for 8 weeks. The primary endpoint was the proportion of patients achieving treatment success ('clear'/'almost clear' skin with ≥2-point improvement in the Physician's Global Assessment of disease severity [PGA]) at Week 8. Secondary endpoints included Hand Eczema Severity Index (HECSI) score changes and the proportion of patients achieving treatment success on the Patient's Global Assessment of disease severity (PaGA).Ninety-one patients were randomised

2019 British Journal of Dermatology Controlled trial quality: predicted high

169. Topical morphine for treatment of cancer-related painful mucosal and cutaneous lesions: a double-blind, placebo-controlled cross-over clinical trial. Full Text available with Trip Pro

the effectiveness and safety of topical morphine for pain related to mucosal lesions and skin ulcers.The study was a 14-day randomized placebo-controlled cross-over trial (RCT) with a 28-day follow-up open phase (OP). The trial was conducted in adult patients with localized cancer-related pain and treated with systemic opioids in an oncology center or home hospice. The patients administered 0.2% gel on the mucosal lesion or 0.2% ointment on the skin lesion by themselves, without restrictions regarding (...) Topical morphine for treatment of cancer-related painful mucosal and cutaneous lesions: a double-blind, placebo-controlled cross-over clinical trial. Painful mucosal and cutaneous lesions are often less responsive or even refractory to systemic opioid analgesics. There is evidence suggesting that the effectiveness of topical morphine be restricted to inflammatory pain. The studied groups were small and the observation period relatively short. The aim of this study was to assess

2019 Archives of medical science : AMS Controlled trial quality: uncertain

170. Monotherapy of topical tacrolimus 0.03% in the treatment of vernal keratoconjunctivitis in the pediatric population. Full Text available with Trip Pro

Monotherapy of topical tacrolimus 0.03% in the treatment of vernal keratoconjunctivitis in the pediatric population. To report the results of treating children with vernal keratoconjunctivitis (VKC) using a monotherapy of topical tacrolimus 0.03%.This was a prospective, nonrandomized observational study of children newly diagnosed with VKC. The severity of the disease was graded on a 4-point scale of symptoms and signs. Patients were treated with tacrolimus 0.03% ointment and were followed (...) at 8 months, also a statistically significant reduction (P < 0.001). Four patients had to be started on steroids within the first month of treatment and were considered treatment failures. Thus, 89% of patients showed significant improvement. No participant experienced adverse effects, although some reported a transient stinging sensation.In our study cohort topical tacrolimus ointment 0.03% as a monotherapy for VKC was successful in the majority of subjects, and there was no adverse

2019 JAAPOS - Journal of the American Association for Pediatric Ophthalmology and Strabismus

171. Efficacy of photodynamic therapy combined with topical interventions for the treatment of actinic keratosis: a meta-analysis. (Abstract)

included. Four studies investigated a combination of PDT with imiquimod cream, three with 5-fluorouracil cream and one each with ingenol mebutate gel, tazarotene gel and calcipotriol ointment, respectively. Patients treated with a combination showed higher participant complete (RR 1.63; 95% CI 1.15-2.33; P = 0.007) and partial clearance rates (RR 1.19; 95% CI 0.84-1.67; P = 0.33). Similarly, the lesion-specific clearance was higher for PDT plus topical intervention compared to monotherapy (RR 1.48; 95 (...) Efficacy of photodynamic therapy combined with topical interventions for the treatment of actinic keratosis: a meta-analysis. Photodynamic therapy (PDT) is a highly effective treatment option for patients with actinic keratoses (AK). However, efficacy can be reduced by insufficient illumination or hyperkeratotic nature of lesions.To investigate if PDT combined with a topical intervention is superior to monotherapy in terms of efficacy and tolerability.A systematic literature research

2019 Journal of the European Academy of Dermatology and Venereology

172. Topical Treatment of Cutaneous Leishmaniasis in Israel, Part 1. (Abstract)

months in patients with Leishmania major and sometimes for more than a year in patients with Leishmania tropica. The disease ends spontaneously, often with disfiguring scars. The aim of the treatment is to significantly shorten the wound-healing process, hopefully with minimal scars and with parasite eradication. Topical treatment for this localized skin disease is very attractive, although only one medication is registered in Israel (15% paromomycin +12% methylbenzethonium chloride ointment), which (...) Topical Treatment of Cutaneous Leishmaniasis in Israel, Part 1. Cutaneous leishmaniasis is the most common form of leishmaniasis with global incidence of about 1.5 million cases annually. The disease is endemic in Israel and caused by two types, Leishmania major and Leishmania tropica. The two types of cutaneous leishmaniasis in Israel are not life threatening, but the multiple skin lesions developed from the contaminated sandfly bites cause significant damage to the quality of life for a few

2019 International journal of pharmaceutical compounding Controlled trial quality: uncertain

173. Topical treatment of nonhealing venous leg ulcer with propolis ointment. Full Text available with Trip Pro

Topical treatment of nonhealing venous leg ulcer with propolis ointment. An investigation of effectiveness of topical treatment of nonhealing chronic venous leg ulcers with propolis ointment was conducted. 56 patients were included in the study and randomized into two groups. In group 1, there were 28 patients (ulceration area: 6.9-9.78 cm(2)) treated by means of topical propolis ointment application and short stretch bandage compression. In group 2, there were 29 patients (ulceration area: 7.2 (...) -9.4 cm(2)) treated by means of Unna boot leg compression without topical propolis treatment. In the study, the efficacy of both treatment methods in patients with resistive venous leg ulcers was compared. The ulceration of patients from group 1 healed completely after 6 weeks of therapy in all cases. In all patients from group 2, the process of healing was longer but successfully completed after 16 weeks of the therapy. We found that an adjunctive propolis ointment treatment increases the efficacy

2013 Evidence-based Complementary and Alternative Medicine (eCAM) Controlled trial quality: uncertain

174. The comparison of efficacy of adcortyl ointment and topical tacrolimus in treatment of erosive oral lichen planus. Full Text available with Trip Pro

The comparison of efficacy of adcortyl ointment and topical tacrolimus in treatment of erosive oral lichen planus. Oral lichen planus (OLP) is a common chronic mucocutaneous disease. Patients with atrophic and erosive lichen planus often have symptoms of soreness and need proper treatment. The main therapy of OLP has been the administration of topical or systemic corticosteroids. Potent topical corticosteroids have been increasingly prescribed in the treatment of erosive lichen planus (...) . The purpose of this study was to compare the efficacy of adcortyl ointment (triamcinolone in orabase) with topical tacrolimus for the treatment of erosive oral lichen planus.Sixty Patients with histopathologically confirmed oral lichen planus were enrolled in the study. The severity of lesions was scored from 0 to 5 according to the criteria described in a previous study. Patients were randomly given adcortyl (group A) and topical tacrolimus ointment (group B) and asked to apply the medication on dried

2013 Journal of dental research, dental clinics, dental prospects Controlled trial quality: uncertain

175. A comparative study to evaluate efficacy, safety and cost-effectiveness between Whitfield's ointment + oral fluconazole versus topical 1% butenafine in tinea infections of skin. Full Text available with Trip Pro

A comparative study to evaluate efficacy, safety and cost-effectiveness between Whitfield's ointment + oral fluconazole versus topical 1% butenafine in tinea infections of skin. The aim of this study is to compare the efficacy, safety and cost-effectiveness of topical Whitfield's ointment plus oral fluconazole with topical 1% butenafine in tinea infections of the skin.Patients were randomly allocated to the two treatment groups and advised to apply either agent topically twice-a-day for 4 weeks (...) on the lesions and fluconazole (150 mg) was administered once a week for 4 weeks in the study group applying Whitfield's ointment. Patients were followed-up at an interval of 10 days for clinical score and global evaluation response was assessed at baseline and during each follow-up.Out of 120 patients enrolled in the study 103 completed the study. Patients treated with Whitfield's ointment and oral fluconazole reduced mean sign and symptom score from 8.81 ± 0.82 to 0.18 ± 0.59 while butenafine treated

2013 Indian journal of pharmacology Controlled trial quality: uncertain

176. Topical Green Tea Ointment in Treatment of Superficial Skin Cancer

Topical Green Tea Ointment in Treatment of Superficial Skin Cancer Topical Green Tea Ointment in Treatment of Superficial Skin Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Topical Green Tea (...) signalling, an important component of the WNT pathway. Sinecatechins 10% ointment (Veregen®) is a standardized extract of green tea leaves of the species Camellia sinensis, containing mainly green tea polyphenols, particularly catechins (more than 85%). The lead catechin in sinecatechins ointment is EGCG. It is approved by the US Food and Drug Administration (FDA) for genital warts in adults. There are no clinical trials on human subjects with topical EGCG on sBCC yet. With this trial we are the first

2013 Clinical Trials

177. Antimicrobial Efficacy and Wound Healing Property of a Topical Ointment Containing Nitric Oxide-Loaded Zeolite. Full Text available with Trip Pro

Antimicrobial Efficacy and Wound Healing Property of a Topical Ointment Containing Nitric Oxide-Loaded Zeolite. Topical delivery of nitric oxide (NO) through a wound dressing has the potential to reduce wound infections and improve healing of acute and chronic wounds. This study characterized the antibacterial efficacy of an ointment containing NO-loaded, zinc-exchanged zeolite A that releases NO upon contact with water. The release rate of NO from the ointment was measured using (...) a chemiluminescence detection system. Minimum bactericidal concentration assays were performed using five common wound pathogens, including Gram-negative bacteria (Escherichia coli and Acinetobacter baumannii), Gram-positive bacteria (Staphylococcus epidermidis and meticillin-resistant Staphylococcus aureus) and a fungus (Candida albicans). The time dependence of antimicrobial activity was characterized by performing log-reduction assays at four time points after 1-8 h ointment exposure. The cytotoxicity

2013 Journal of Medical Microbiology

178. Topical glyceryl trinitrate ointment for pain related to anal hypertonia after stapled hemorrhoidopexy: a randomized controlled trial. (Abstract)

Topical glyceryl trinitrate ointment for pain related to anal hypertonia after stapled hemorrhoidopexy: a randomized controlled trial. Postoperative pain after stapled hemorrhoidopexy is cause for considerable concern and may be related to contracture of continence muscles.We compared glyceryl trinitrate 0.4% ointment with lidocaine chlorohydrate 2.5% gel as topical therapy to relieve the pain of anorectal muscular spasm after stapled hemorrhoidopexy.This was a single-blind, parallel-group (...) , randomized controlled trial.The study was conducted at a university teaching hospital in Rome, Italy.Patients with severe postoperative anal pain after stapled hemorrhoidopexy, clinical evidence of anal hypertonia, and elevated anal resting pressure on manometric assessment were enrolled. Patients treated for concomitant anorectal disease were excluded.Participants were randomly assigned to receive twice-daily, local topical application of glyceryl trinitrate or lidocaine for a total of 14 days.Pain

2013 Diseases of the colon and rectum Controlled trial quality: predicted high

179. Comparative evaluation of topical calcipotriol versus coal tar and salicylic acid ointment in chronic plaque psoriasis. (Abstract)

Comparative evaluation of topical calcipotriol versus coal tar and salicylic acid ointment in chronic plaque psoriasis. Calcipotriol is a newer topical treatment option available for plaque psoriasis and coal tar being one of the oldest treatment and still in use.To evaluate and compare the differences in terms of efficacy, safety and relapse with Calcipotriol 0.005% (50 mcg/gm) and 6% coal tar and 3% salicylic ointment in patients with Plaque psoriasis. SETTING andStudy conducted on 60 (...) patients of plaque psoriasis, who attended the skin OPD in our hospital.The patients with mild to moderate plaque psoriasis were selected. 60 patients were enrolled for the study after obtaining informed consent. Subjects were asked to apply Calcipotriol 0.005% (50 mcg/gm) (Heximar Win care) twice a day on the right side plaques and on left side plaques, Petroleum jelly (Vaseline) in the morning and 6% coal tar and 3% salicylic ointment (Protar® Percos) at nighttime. PASI score was used to assess

2013 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

180. Cost-effectiveness of tacrolimus ointment in adults and children with moderate and severe atopic dermatitis: twice-weekly maintenance treatment vs. standard twice-daily reactive treatment of exacerbations from a third party payer (UK National Health Servi Full Text available with Trip Pro

assessment for children. Measure of benefit: The measure of benefit was quality-adjusted life-years (QALYs). Cost data: The direct medical costs included the tacrolimus ointment, consultant dermatology and out-patient visits, phototherapy, topical steroids, oral medications, and in-patient stays. Published sources were used to measure and value these resources. These included MIMS 2009, NHS National Reference Costs, and the Personal Social Services Research Unit 2008. The costs of discontinuing (...) simulations at the acceptability threshold of £30,000 per QALY. Authors' conclusions The authors concluded that maintenance therapy, using tacrolimus ointment, for children and adults with moderate or severe atopic dermatitis, produced additional health benefits, at lower costs, and was cost-effective, compared with reactive treatment. CRD commentary Interventions: The two strategies were well described. It was unclear why topical corticosteroids and topical calcineurin inhibitors were not analysed, given

2011 NHS Economic Evaluation Database.

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