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Topical Ointment

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141. Topical tacrolimus for atopic dermatitis. (PubMed)

Topical tacrolimus for atopic dermatitis. Atopic dermatitis (AD) (or atopic eczema) is a chronic inflammatory skin condition that affects children and adults and has an important impact on quality of life. Topical corticosteroids (TCS) are the first-line therapy for this condition; however, they can be associated with significant adverse effects when used chronically. Tacrolimus ointment (in its 2 manufactured strengths of 0.1% and 0.03%) might be an alternative treatment. Tacrolimus, together (...) with pimecrolimus, are drugs called topical calcineurin inhibitors (TCIs).To assess the efficacy and safety of topical tacrolimus for moderate and severe atopic dermatitis compared with other active treatments.We searched the following databases up to 3 June 2015: the Cochrane Skin Group Specialised Register, CENTRAL in the Cochrane Library (Issue 5, 2015), MEDLINE (from 1946), EMBASE (from 1974), LILACS (from 1982), and the Global Resource of Eczema Trials (GREAT database). We searched six trials registers

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2015 Cochrane

142. Topical corticosteroids for treating phimosis in boys. (PubMed)

Topical corticosteroids for treating phimosis in boys. Until recently, phimosis has been treated surgically by circumcision or prepuceplasty; however, recent reports of non-invasive treatment using topical corticosteroids applied for four to eight weeks have been favourable. The efficacy and safety of topical corticosteroids for treating phimosis in boys has not been previously systematically reviewed.We aimed to 1) compare the effectiveness of the use of topical corticosteroid ointment applied (...) to this review. Date of last search: 16 June 2014.We included all randomised controlled trials (RCTs) that compared use of any topical corticosteroid ointment with placebo ointment or no treatment for boys with phimosis.Two authors independently assessed titles, abstracts and the full-text of eligible studies, extracted data relating to the review's primary and secondary outcomes, and assessed studies' risk of bias. Statistical analyses were performed using the random-effects model and results were expressed

2014 Cochrane

143. Topical antifungal treatments for tinea cruris and tinea corporis. (PubMed)

also provide similar clinical and mycological cure rates, particularly azoles although most were evaluated in single studies.There is insufficient evidence to determine if Whitfield's ointment, a widely used agent is effective.Although combinations of topical steroids and antifungals are not currently recommended in any clinical guidelines, relevant studies included in this review reported higher clinical cure rates with similar mycological cure rates at the end of treatment, but the quality (...) Topical antifungal treatments for tinea cruris and tinea corporis. Tinea infections are fungal infections of the skin caused by dermatophytes. It is estimated that 10% to 20% of the world population is affected by fungal skin infections. Sites of infection vary according to geographical location, the organism involved, and environmental and cultural differences. Both tinea corporis, also referred to as 'ringworm' and tinea cruris or 'jock itch' are conditions frequently seen by primary care

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2014 Cochrane

144. External genital and perianal warts: green tea (Camellia sinensis) leaf extract 10% ointment

summaries of product characteristics (SPCs), British national formulary (BNF) or the MHRA or NICE websites for up-to-date information. Summary Green tea (Camellia sinensis) leaf extract 10% ointment (Catephen) is a self-administered topical treatment for external genital and perianal warts. In 2 randomised controlled trials (RCTs) involving a total of 1005 adults, green tea leaf extract 10% ointment was 2-fold more effective than vehicle (placebo) ointment in terms of complete clearance of all baseline (...) with the person. There are 3 self-administered topical treatment options for external genital and perianal warts. All can cause local skin reactions. The maximum treatment duration for green tea leaf extract ointment is 16 weeks, with application 3 times a day. The maximum duration ranges from 4 to 5 weeks for podophyllotoxin preparations to 16 weeks for imiquimod 5% cream. These treatments require less frequent administration than green tea leaf extract ointment. These 3 treatments are available in a variety

2015 National Institute for Health and Clinical Excellence - Advice

145. Ping On, An Herbal Ointment, May Be More Effective Than Placebo For Reducing Pain And Severity Of TMD Pain In Adult Patients

Ping On, An Herbal Ointment, May Be More Effective Than Placebo For Reducing Pain And Severity Of TMD Pain In Adult Patients UTCAT2273, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Ping On, An Herbal Ointment, May Be More Effective Than Placebo For Reducing Pain And Severity Of TMD Pain In Adult Patients Clinical Question In an adult patient with TMD, are herbal remedies more effective than placebo in reducing (...) the severity or duration of pain? Clinical Bottom Line Ping On, an herbal ointment, may be more effective than placebo for reducing pain and severity of TMD pain in adult patients. Other herbal treatment would need additional investigation. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Li/2009 Patients with TMJ and/ or masticatory pain Double Blind Randomized Control Trial Key results Ping On ointment

2012 UTHSCSA Dental School CAT Library

146. Green tea leaf extract (Veregen) - an aggressive topical treatment for anogenital warts

In patients with troublesome anogenital wart s, who are able and willing to apply a topical treatment themselves, ointment containing green tea leaf extract has no demonstrated advantages in terms of efficacy, adverse effects or convenience over topical treatments containing imiquimod or podophyllotoxin. In practice , it is better to choose the better established drugs imiquimod or podophyllotoxin. Full text available for free download. ©Prescrire 1 April 2015 Download the full review See also (...) Green tea leaf extract (Veregen) - an aggressive topical treatment for anogenital warts Prescrire IN ENGLISH - Spotlight ''In the April issue of Prescrire International: Green tea leaf extract (Veregen°) - an aggressive topical treatment for anogenital warts'', 1 April 2015 {1} {1} {1} | | > > > In the April issue of Prescrire International: Green tea leaf extract (Veregen°) - an aggressive topical treatment for anogenital warts Spotlight Every month, the subjects in Prescrire’s Spotlight. 100

2015 Prescrire

147. Topical Nitroglycerin for Peripheral Circulation and Wound Healing in the Elderly

with peripheral vascular disease Intervention Topical nitroglycerin (e.g., ointment, paste, patches) Comparator ? Placebo or no treatment ? No comparator Outcomes Q1: Clinical effectiveness: ? Benefits (e.g., increased circulation, wound healing) ? Harms (e.g., hypotension, falls, localized skin sensitivity) Q2: Evidence-based guidelines Study Designs Health technology assessments, systematic reviews, meta-analyses, randomized controlled trials, non-randomized studies, evidence-based guidelines RESULTS Rapid (...) action on thrombophlebitis induced by sclerosis of leg varicose veins. Angiology. 1994 May;45(5):347-51. PubMed: PM8172381 6. Fischer M, Reinhold B, Falck H, Torok M, Alexander K. Topical nitroglycerin ointment in Raynaud's phenomenon. Z Kardiol. 1985 May;74(5):298-302. PubMed: PM3925656 7. Franks AG, Jr. Topical glyceryl trinitrate as adjunctive treatment in Raynaud's disease. Lancet. 1982 Jan 9;1(8263):76-7. PubMed: PM6119495 Non-Randomized Studies Unclear Population Age 8. Anderson ME, Moore TL

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

148. Do any topical agents help prevent or reduce stretch marks?

Do any topical agents help prevent or reduce stretch marks? Do any topical agents help prevent or reduce stretch marks? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Do any topical agents help prevent or reduce stretch marks? View/ Open Date 2012-12 Format Metadata Abstract No topical agent has been proven to prevent (...) or reduce stretch marks. Randomized controlled trials (RCTs) show that cocoa butter doesn't prevent stretch marks (strength of recommendation [SOR]: A, 2 RCTs); neither does olive oil (SOR: B, 1 small RCT). A cream containing Centella asiatica extract, vitamin E, and collagen hydrolysates doesn't prevent new stretch marks but might avoid additional stretch marks in women who had already developed them during puberty. Massage with vitamin E ointment alone may reduce the number of stretch marks (SOR: C, 2

2014 Clinical Inquiries

149. Effect of Vitamin E Ointment on Incisional SSI in Colorectal Surgery

2015 Actual Primary Completion Date : March 2016 Actual Study Completion Date : March 2016 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Vitamin E ointment application Before the skin stapling and after the subcutaneous irrigation with normal saline, sterile Vitamin E acetate ointment was applied in the subcutaneous tissue; 2 ml were applied in the suprapubic incision and 0.5 ml (...) Effect of Vitamin E Ointment on Incisional SSI in Colorectal Surgery Effect of Vitamin E Ointment on Incisional SSI in Colorectal Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect of Vitamin E

2016 Clinical Trials

150. Efficacy and Safety of VDA-1102 Ointment in the Treatment of Actinic Keratosis

, Placebo-Controlled, Parallel-Cohort Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Once-Daily Application of Topical VDA-1102 Ointment for 28 Days in Subjects With Actinic Keratosis Actual Study Start Date : July 2016 Actual Primary Completion Date : May 2017 Actual Study Completion Date : May 2017 Resource links provided by the National Library of Medicine resources: Arms and Interventions Go to Arm Intervention/treatment Placebo Comparator: Placebo Drug: Placebo 200 mg (...) applied once-daily for 28 days Other Names: Excipients alone Matched-placebo Experimental: 5% VDA-1102 Drug: 5% VDA-1102 200 mg applied once-daily for 28 days Other Name: 5% VDA-1102 topical dermal ointment Experimental: 10% VDA-1102 Drug: 10% VDA-1102 200 mg applied once-daily for 28 days Other Name: 10% VDA-1102 topical dermal ointment Outcome Measures Go to Primary Outcome Measures : Number of actinic keratosis lesions in the Treatment Field [ Time Frame: 56 days ] Secondary Outcome Measures

2016 Clinical Trials

151. Trial on Efficacy and Safety of Pritelivir Ointment for Treatment of Labial Herpes

Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Pritelivir 5% w/w ointment Topical treatment (20 applications), 5 times daily for 4 days Drug: Pritelivir 5% w/w ointment Placebo Comparator: Pritelivir ointment matching placebo Topical treatment (20 applications), 5 times daily for 4 days Drug: Pritelivir ointment matching placebo Active Comparator: Zovirax® cream Topical treatment (20 applications), 5 times daily for 4 days Drug (...) Trial on Efficacy and Safety of Pritelivir Ointment for Treatment of Labial Herpes Trial on Efficacy and Safety of Pritelivir Ointment for Treatment of Labial Herpes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2016 Clinical Trials

152. Trial to Assess the Potency of SOR007 Ointment in a Psoriasis Plaque Test

. Information provided by (Responsible Party): DFB Soria, LLC Study Details Study Description Go to Brief Summary: Evaluation of safety, pharmacokinetics, and anti-psoriatic efficacy to assess SOR007 Ointment in topical formulations Condition or disease Intervention/treatment Phase Plaque Psoriasis Drug: SOR007 Ointment 2.0% Drug: SOR007 Ointment 1.0% Drug: SOR007 Ointment 0.3% Drug: SOR007 Ointment 0.15% Drug: SOR007 Ointment Placebo Drug: Taclonex® Ointment Phase 1 Detailed Description: This is a two (...) -center, randomized, placebo- and active comparator-controlled trial that will be double-blind for the investigational products (IPs) and observer-blind for the active comparator with intra-individual comparison of treatments. Twelve male and post-menopausal female volunteer subjects, aged 18 years or older, with psoriasis vulgaris and mild or moderate chronic plaque(s) in a stable phase and an area sufficient for six treatment fields, will be enrolled. SOR007 Ointment will be administered topically

2016 Clinical Trials

153. A Study of GSK2981278 Ointment in Subjects With Plaque Psoriasis

Study Description Go to Brief Summary: GSK2981278 is an inverse agonist of retinoic acid receptor-related orphan receptor (ROR) gamma. The aim of this study is to evaluate the safety, tolerability, clinical effect, and systemic exposure potential of topically applied GSK2981278 ointment in subjects with plaque psoriasis by treating all plaques on the body for 8 weeks. This single-center study will be conducted in two parts. Part A will be an open-label, single arm study and part B will be a double (...) Drug: Vehicle ointment Phase 2 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 8 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Participant, Investigator) Primary Purpose: Treatment Official Title: A Two-part Trial to Evaluate the Safety, Tolerability, Clinical Effect and Systemic Exposure Potential of Topically Applied GSK2981278 Ointment in Subjects With Plaque Psoriasis Actual

2016 Clinical Trials

154. Trial Twice Daily Application of LEO 124249 Ointment 30 mg/g in Treatment of Mild to Moderate Inverse Psoriasis

: September 2016 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: LEO 124249 ointment 30 mg/g Drug LEO 124249 ointment 30 mg/g twice daily application for 6 weeks, maximum of 1.44 g ointment per day Drug: LEO 124249 ointment 30 mg/g Placebo Comparator: LEO 124249 ointment vehicle LEO 124249 ointment vehicle twice daily application for 6 weeks, maximum of 1.44 g ointment per day Other: LEO 124249 ointment (...) Trial Twice Daily Application of LEO 124249 Ointment 30 mg/g in Treatment of Mild to Moderate Inverse Psoriasis Trial Twice Daily Application of LEO 124249 Ointment 30 mg/g in Treatment of Mild to Moderate Inverse Psoriasis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2016 Clinical Trials

155. Trial Comparing Calmoseptine Ointment and Desitin Diaper Rash Paste in Diaper Dermatitis in Neonates and Infants

Oxide Diaper Rash Paste in Diaper Dermatitis in Neonates and Infants Study Start Date : March 2015 Estimated Primary Completion Date : March 2017 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Calmoseptine Ointment Calmoseptine Ointment as part of a structured skin care regimen. Drug: Calmoseptine Ointment A full structured skin care regimen is provided in a consistent fashion (...) such that trial participation may constitute a risk, or may interfere with their medical care, or affect interpretation of results, or their attending physician advises against participation. Participant is on systemic antifungal treatment (eg. Amphotericin B or Fluconazole), topical antifungal treatment and / or systemic or topical corticosteroids. Participant has in the preceding week been treated with topical agents that may affect healing (e.g. dimethicone based ointments, zinc oxide powder, petroleum

2016 Clinical Trials

156. Comparison of Mepitel Ag vs Antibiotic Ointment Used With Soft Cast Technique for Treatment of Pediatric Burns

and Foot Burns, a Prospective Study Study Start Date : September 2016 Estimated Primary Completion Date : December 2019 Estimated Study Completion Date : December 2019 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Control- triple antibiotic ointment triple antibiotic ointment (TAO) impregnated Adaptic gauze, kling or kerlex, cast padding, gypsoma plaster, soft cast material, and coban Device: triple (...) Comparison of Mepitel Ag vs Antibiotic Ointment Used With Soft Cast Technique for Treatment of Pediatric Burns Comparison of Mepitel Ag vs Antibiotic Ointment Used With Soft Cast Technique for Treatment of Pediatric Burns - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2016 Clinical Trials

157. A Bioequivalence Study to Compare the Pharmacokinetics (PK) Of Marketed Product TobraDex® To An Experimental Ophthalmic Sterile Ointment Containing Tobramycin And Dexamethasone In Aqueous Humor In Patients Undergoing Indicated Cataract Surgery

links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: tobramycin and dexamethasone ophthalmic test ointment The test drug (tobramycin is an aminoglycoside antibiotic and dexamethasone is a corticosteroid) will be administered in one eye before the cataract surgery. Drug: cataract surgery the patient will be dosed with the study drug into the "V" pocket is formed between the eye ball and the lower eyelid (...) A Bioequivalence Study to Compare the Pharmacokinetics (PK) Of Marketed Product TobraDex® To An Experimental Ophthalmic Sterile Ointment Containing Tobramycin And Dexamethasone In Aqueous Humor In Patients Undergoing Indicated Cataract Surgery A Bioequivalence Study to Compare the Pharmacokinetics (PK) Of Marketed Product TobraDex® To An Experimental Ophthalmic Sterile Ointment Containing Tobramycin And Dexamethasone In Aqueous Humor In Patients Undergoing Indicated Cataract Surgery - Full

2016 Clinical Trials

158. Proof of Concept, Twice Daily Applications of LEO 124249 Ointment in the Treatment of Chronic Hand Eczema

Completion Date : October 2016 Resource links provided by the National Library of Medicine related topics: related topics: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: LEO 124249 ointment Twice daily cutaneous application for 8 weeks Drug: LEO 124249 ointment Ointment Placebo Comparator: LEO 124249 ointment vehicle Twice daily cutaneous application for 8 weeks Drug: LEO 124249 ointment vehicle Ointment vehicle Outcome Measures Go to Primary Outcome Measures : Subjects (...) Proof of Concept, Twice Daily Applications of LEO 124249 Ointment in the Treatment of Chronic Hand Eczema Proof of Concept, Twice Daily Applications of LEO 124249 Ointment in the Treatment of Chronic Hand Eczema - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2016 Clinical Trials

159. The Treatment Effect of Chinese Herbal Compound Ointment on Atrophic Vaginitis

Detailed Description: 80 postmenopausal women living in the communities near the hospital with AV (atrophic vaginitis) symptoms were recruited for this clinical trial. Patients with AV receiving external treatment and requiring hospitalization were randomized in a double-blind, single-centre trial. Subjects received CHCO (Chinese Herbal Compound Ointment) topical vaginal application in experimental group, while estriol in control group. The dosage of medicine for single treatment once a day in two (...) , Investigator, Outcomes Assessor) Primary Purpose: Treatment Study Start Date : February 2016 Estimated Primary Completion Date : May 2016 Estimated Study Completion Date : June 2016 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Chinese Herbal Compound Ointment This kind of CHCO composed of several chinese herbs,dong quai,angelica,resina draconis and lithospermum.The dosage of medicine

2016 Clinical Trials

160. A Trial That Compound Clobetasol Propionate Ointment Treats Patients With Mild to Moderate Psoriasis Vulgaris.

: Interventional (Clinical Trial) Actual Enrollment : 240 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Investigator) Primary Purpose: Treatment Study Start Date : April 2015 Actual Primary Completion Date : April 2016 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: test group Compound Clobetasol Propionate Ointment Drug: Compound Clobetasol Propionate (...) A Trial That Compound Clobetasol Propionate Ointment Treats Patients With Mild to Moderate Psoriasis Vulgaris. A Trial That Compound Clobetasol Propionate Ointment Treats Patients With Mild to Moderate Psoriasis Vulgaris. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2016 Clinical Trials

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