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Topical Ointment

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141. Safety and Efficacy of AN2728 Topical Ointment, 2% in Children, Adolescents, and Adults (Ages 2 Years and Older) With Atopic Dermatitis

Safety and Efficacy of AN2728 Topical Ointment, 2% in Children, Adolescents, and Adults (Ages 2 Years and Older) With Atopic Dermatitis Safety and Efficacy of AN2728 Topical Ointment, 2% in Children, Adolescents, and Adults (Ages 2 Years and Older) With Atopic Dermatitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning (...) You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Safety and Efficacy of AN2728 Topical Ointment, 2% in Children, Adolescents, and Adults (Ages 2 Years and Older) With Atopic Dermatitis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier

2014 Clinical Trials

142. Safety and Efficacy of AN2728 Topical Ointment, 2% in Children, Adolescents, and Adults (Aged 2 Years and Older) With Atopic Dermatitis

Safety and Efficacy of AN2728 Topical Ointment, 2% in Children, Adolescents, and Adults (Aged 2 Years and Older) With Atopic Dermatitis Safety and Efficacy of AN2728 Topical Ointment, 2% in Children, Adolescents, and Adults (Aged 2 Years and Older) With Atopic Dermatitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning (...) You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Safety and Efficacy of AN2728 Topical Ointment, 2% in Children, Adolescents, and Adults (Aged 2 Years and Older) With Atopic Dermatitis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier

2014 Clinical Trials

143. A randomized, double-blind, comparative study to assess the safety and efficacy of topical retapamulin ointment 1% versus oral linezolid in the treatment of secondarily infected traumatic lesions and impetigo due to methicillin-resistant Staphylococcus au (Abstract)

A randomized, double-blind, comparative study to assess the safety and efficacy of topical retapamulin ointment 1% versus oral linezolid in the treatment of secondarily infected traumatic lesions and impetigo due to methicillin-resistant Staphylococcus au To evaluate the clinical and bacteriological efficacy of topical retapamulin ointment 1% versus oral linezolid in the treatment of patients with secondarily infected traumatic lesions (SITLs; excluding abscesses) or impetigo due to methicillin (...) -resistant Staphylococcus aureus (MRSA).A randomized, double-blind, double-dummy, multicenter, comparative study (NCT00852540).Patients recruited from 36 study centers in the United States.Patients 2 months or older with SITL (including secondarily infected lacerations or sutured wounds) or impetigo (bullous and nonbullous) suitable for treatment with a topical antibiotic, with a total Skin Infection Rating Scale score of 8 or greater, including a pus/exudate score of 3 or greater.Patients received

2014 Advances in skin & wound care Controlled trial quality: predicted high

144. Combination treatment of oral terbinafine with topical terbinafine and 10% urea ointment in hyperkeratotic type tinea pedis. (Abstract)

Combination treatment of oral terbinafine with topical terbinafine and 10% urea ointment in hyperkeratotic type tinea pedis. Hyperkeratotic-type tinea pedis is chronic and recalcitrant to topical antifungal agents. Some topical antifungal agents are effective; however, long duration of therapy is required, which often reduce the treatment compliance of patients. To seek for short period therapy of hyperkeratotic type tinea pedis, in this study, we observed the efficacy and safety of treatment (...) of topical terbinafine and 10% urea ointment combined oral terbinafine. Participants with hyperkeratotic type tinea pedis were randomly assigned to two groups. Patients in group I were treated with oral terbinafine for 2 weeks and topical terbinafine and 10% urea ointment for 4 weeks, whereas in group II, only the above topical agents were applied for 12 weeks. Clinical improvement rates and fungal eradication rates were compared between the two groups at 24 weeks after the initiation of treatment

2014 Mycoses Controlled trial quality: uncertain

145. The Effect Of Topical Ointment On Neonatal Sepsis In Preterm Infants. (Abstract)

The Effect Of Topical Ointment On Neonatal Sepsis In Preterm Infants. To investigate the effects of topical ointment therapy on neonatal sepsis in premature infants.A total of 197 premature infants≤34 weeks gestation were randomized to receive topical ointment (Aquaphor Original Emollient) or routine skin care group. Skin cultures were obtained on 3th, 7th and 14th day and blood cultures were obtained if sepsis was suspected clinically. Data included the maternal and neonatal characteristics (...) and necrotizing enterocolitis between the groups. Although the rate of death was higher in the topical ointment group, no statistically significant difference was found between the groups.Our data suggests that applying topical ointment during the first 2 postnatal weeks did not affect the risk of neonatal sepsis in preterm infants, although it changed the bacterial flora on the skin compare to the routine care group.

2014 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Controlled trial quality: uncertain

146. Corticosteroids - topical (skin), nose, and eyes

and Minims®). Fluorometholone (ophthalmic suspension). Hydrocortisone acetate (drops and ointment). Loteprednol etabonate (ophthalmic suspension). Prednisolone (drops and Minims®). Rimexolone (drops). [ ] Management Management : covers the management of people receiving topical (skin) corticosteroids in primary care. : covers the management of people receiving intranasal corticosteroids in primary care. : covers the management of people receiving corticosteroid eye preparations. Although corticosteroid (...) not require treatment. For the application of corticosteroids and emollients together, see the section on . Table 2. Topical corticosteroids listed by potency class. Potency class Non-proprietary names and strengths Proprietary names Formulations Mild Hydrocortisone 0.1%, 0.5%, 1.0%, 2.5% Generic hydrocortisone, Dioderm®, Efcortelan®, Mildison® Cream and ointment Moderate Alclometasone dipropionate 0.05% Modrasone® Cream and ointment Betamethasone valerate 0.025% Betnovate-RD® Cream and ointment

2018 NICE Clinical Knowledge Summaries

147. Topical administration

with the child/ young person and family ( ): discuss what the treatment involves and duration discuss reasons for administration and application discuss side effects of treatment provide written information give a named contact Administration Gather the following equipment: ( ) topical cream/ointment silver foil bowls plastic spoon apron gloves (ensure non latex) ( ) Wash hands and put on apron and gloves ( ). Check topical cream/ointment with prescription chart adhering to hospital medicine administration (...) policy for identifying correct patient ( ). Apply patient named sticker onto cream tube/bottle ( ). If cream/ointment does not come in a tube or pump dispenser, decant sufficient cream for that administration into a silver foil bowl with plastic spoon ( ). Ensure the child’s/young person’s skin is cleansed thoroughly with a disposable washcloth and prescribed soap substitute ( ). If the child/young person is having a bath prior to topical administration, a bath emollient should be used to reduce

2015 Publication 1593

148. Insect Bites - Guidelines for Prescribing Topical Hydrocortisone

that topically applied vinegar to neutralize wasp stings will be effective as the venom spreads deep into tissues within a few minutes. Prescription drug option Hydrocortisone 1% cream, lotion or ointment is indicated for topical therapy where anti-inflammatory, anti-allergic and anti-pruritic activity is required. Hydrocortisone 1% is considered a mild corticosteroid. Note: Hydrocortisone 1% is Schedule 1 (Rx) only for patients under 2. Otherwise, it is an OTC product that is not eligible for the minor (...) their application. If a reaction to a repellent is suspected, wash off, seek medical attention and take container with you. HYDROCORTISONE (< 2 years of age) 1% TOPICAL CREAM 1% TOPICAL OINTMENT 1% TOPICAL LOTION pseudoDIN: 00951089 Max of 8 claims per 365 days per patient May prescribe sufficient quantity to treat up to 7 days, no refills. For help prescribing the proper quantity of topicals using finger-tip units, see: C-Health - (Free access) Saskatchewan HealthLine online - (Free access) Canadian

2016 medSask

149. Treatment with silver nitrate versus topical steroid treatment for umbilical granuloma: A non-inferiority randomized control trial. Full Text available with Trip Pro

Treatment with silver nitrate versus topical steroid treatment for umbilical granuloma: A non-inferiority randomized control trial. The aim of this prospective multicenter randomized controlled trial was to compare the efficacy of silver nitrate cauterization against that of topical steroid ointment in the treatment of neonatal umbilical granuloma.An open-label, non-inferiority randomized controlled trial was conducted from January 2013 to January 2016. The primary endpoint for the silver (...) nitrate cauterization and topical steroid ointment groups was the healing rate after 2 weeks of treatment, applying a non-inferiority margin of 10%. The healing rate was evaluated until completion of 3 weeks of treatment.Participants comprised 207 neonates with newly diagnosed umbilical granuloma, randomized to receive silver nitrate cauterization (n = 104) or topical steroid ointment (n = 103). Healing rates after 2 weeks of treatment were 87.5% (91/104) in the silver nitrate cauterization and 82

2018 PLoS ONE Controlled trial quality: uncertain

150. Topical miconazole, including oral gel: reminder of potential for serious interactions with warfarin

if they are receiving warfarin before using products that contain miconazole (including those available without prescription), and to seek medical advice if they notice signs of over-anticoagulation during treatment, such as sudden unexplained bruising, nosebleeds or blood in the urine Miconazole (Daktarin, Daktacort) is an antifungal indicated for prevention and treatment of various infections of the mouth, throat, skin, nails, or genitals. It is usually applied topically as a cream, ointment, powder, or oral gel (...) Topical miconazole, including oral gel: reminder of potential for serious interactions with warfarin Topical miconazole, including oral gel: reminder of potential for serious interactions with warfarin - GOV.UK GOV.UK uses cookies to make the site simpler. Search Topical miconazole, including oral gel: reminder of potential for serious interactions with warfarin In view of reports of serious bleeding events in patients taking miconazole and warfarin, we are considering further measures

2016 MHRA Drug Safety Update

151. Total Occlusive Ionic Silver-Containing Dressing vs Mupirocin Ointment Application vs Conventional Dressing in Elective Colorectal Surgery: Effect on Incisional Surgical Site Infection (Abstract)

and standard dressing groups; a significant difference was observed between ISD and MOA (relative risk [RR] 4.5; 95% CI (1.1 to 19.8); p = 0.046) and between the standard group and the MOA group (RR 5; 95% CI (1.2 to 21.7); p = 0.031).Topical application of mupirocin ointment achieves better results for the prevention of SSI than ionic silver-containing dressing or standard dressing in patients undergoing elective open colorectal surgery.Copyright © 2015 American College of Surgeons. Published by Elsevier (...) Total Occlusive Ionic Silver-Containing Dressing vs Mupirocin Ointment Application vs Conventional Dressing in Elective Colorectal Surgery: Effect on Incisional Surgical Site Infection Several pre- and intraoperative factors have been associated with incisional surgical site infection (SSI), but little is known about the influence of postoperative wound care and especially, the use of different dressings on incisional SSI. The aim of this study was to compare 3 methods of wound dressings

2015 EvidenceUpdates Controlled trial quality: uncertain

152. Tacrolimus Ointment

: Tacrolimus Ointment , Protopic , Elidel , Pimecrolimus From Related Chapters II. Indications Severe refractory III. Pharmacokinetics Normal topical use causes <5 ng/ml serum concentration Greater absorption in severely damaged skin Factors increasing serum concentrations Higher doses or greater surface area of application Inflamed skin IV. Mechanism with similar activity to Specifically binds T Cell receptors Inhibits cytokine production Inhibits IgE sensitivity V. Precautions Increased risk of skin (...) Tacrolimus Ointment Tacrolimus Ointment Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Tacrolimus Ointment Tacrolimus Ointment Aka

2018 FP Notebook

153. Do any topical agents help prevent or reduce stretch marks?

Do any topical agents help prevent or reduce stretch marks? Do any topical agents help prevent or reduce stretch marks? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Do any topical agents help prevent or reduce stretch marks? View/ Open Date 2012-12 Format Metadata Abstract No topical agent has been proven to prevent (...) or reduce stretch marks. Randomized controlled trials (RCTs) show that cocoa butter doesn't prevent stretch marks (strength of recommendation [SOR]: A, 2 RCTs); neither does olive oil (SOR: B, 1 small RCT). A cream containing Centella asiatica extract, vitamin E, and collagen hydrolysates doesn't prevent new stretch marks but might avoid additional stretch marks in women who had already developed them during puberty. Massage with vitamin E ointment alone may reduce the number of stretch marks (SOR: C, 2

2014 Clinical Inquiries

154. Cost-effectiveness of tacrolimus ointment in adults and children with moderate and severe atopic dermatitis: twice-weekly maintenance treatment vs. standard twice-daily reactive treatment of exacerbations from a third party payer (UK National Health Servi Full Text available with Trip Pro

assessment for children. Measure of benefit: The measure of benefit was quality-adjusted life-years (QALYs). Cost data: The direct medical costs included the tacrolimus ointment, consultant dermatology and out-patient visits, phototherapy, topical steroids, oral medications, and in-patient stays. Published sources were used to measure and value these resources. These included MIMS 2009, NHS National Reference Costs, and the Personal Social Services Research Unit 2008. The costs of discontinuing (...) simulations at the acceptability threshold of £30,000 per QALY. Authors' conclusions The authors concluded that maintenance therapy, using tacrolimus ointment, for children and adults with moderate or severe atopic dermatitis, produced additional health benefits, at lower costs, and was cost-effective, compared with reactive treatment. CRD commentary Interventions: The two strategies were well described. It was unclear why topical corticosteroids and topical calcineurin inhibitors were not analysed, given

2011 NHS Economic Evaluation Database.

155. Effect of Topical Garlic on Wound Healing and Scarring: A Clinical Trial. (Abstract)

Effect of Topical Garlic on Wound Healing and Scarring: A Clinical Trial. Historically, garlic containing compounds have been used on wounds to improve healing and ward off infection. Researchers have tested many of these ancient ointments, discovering that garlic is a common ingredient in those that are effective.To determine the efficacy of topical garlic on surgical wounds compared with Vaseline by analysis of visual analog scales and digital photograph analysis.Seventeen patients with 2 (...) skin excisions applied a 30% garlic ointment to one surgical wound and Vaseline to the other surgical wound twice daily. They were followed up at 2 weeks and 4 weeks post-op. Digital photographs were taken of the sites, and wound visual analog scales were filled out by the patient and the physician.Patients and the onsite physician stated the garlic site healed better in 59% and 65% of the wounds, respectively, at 2 weeks. At 4 weeks, the patients and the onsite physician stated the garlic site

2019 Dermatologic Surgery

156. Comparison of the safety and efficacy of topical Tacrolimus (0.03%) versus dexamethasone (0.05%) for subepithelial infiltrates after adenoviral conjunctivitis. Full Text available with Trip Pro

Comparison of the safety and efficacy of topical Tacrolimus (0.03%) versus dexamethasone (0.05%) for subepithelial infiltrates after adenoviral conjunctivitis. To compare the safety and efficacy of tacrolimus 0.03% ointment with dexamethasone 0.05% ointment for subepithelial infiltrates (SEIs) following adenoviral keratoconjunctivitis (AK).A randomized, double blind trial was done. Eligibility criteria was corrected distance visual acuity of 6/9 Snellen or worse for at least 4 weeks (...) with corneal SEIs following AK. The grading of SEIs was done on a scale of 0 to 3; 0, no infiltrates, 1 mild infiltration, 2 moderate infiltration and 3, severe infiltration. Consecutive patients with SEIs following AK were randomized to receive either topical tacrolimus 0.03% or dexamethasone 0.05% ointment twice daily for 6 months. Treatment was successful if there was reduction of SEIs and improvement in vision.A total of 45 patients each were assigned to the Tacro and Dexa groups, respectively

2019 Indian journal of ophthalmology Controlled trial quality: uncertain

157. CD101 Topical Compared With Oral Fluconazole for Acute Vulvovaginal Candidiasis: A Randomized Controlled Trial. (Abstract)

CD101 Topical Compared With Oral Fluconazole for Acute Vulvovaginal Candidiasis: A Randomized Controlled Trial. Vulvovaginal candidiasis (VVC) is an infection of the vagina's mucous membranes, caused by Candida albicans in more than 90% of acute VVC. Several topical and oral azole agents are available in a variety of formulations, and all seem to have similar effectiveness. Azoles are fungistatic, meaning that the fungi are inhibited from growth or replication but are not eradicated. Recurrent (...) infection and developing azole resistance demonstrate a significant need for alternative treatments.One hundred twenty-six women were randomized to 1 of the following 3 treatment cohorts: CD101 3% gel (n = 50) applied intravaginally on days 1 and 2, CD101 6% ointment (n = 50) applied intravaginally on day 1, or oral fluconazole 150 mg (n = 26) on day 1. Primary outcomes of clinical and mycological cure, as demonstrated by changes in the vaginal scores and mycological culture, were assessed on day 7 (±2

2019 Journal of lower genital tract disease Controlled trial quality: uncertain

158. Ozenoxacin Cream, 1% - Topical Treatment of Impetigo. (Abstract)

Department of Medicine, Baylor University Medical Center, Dallas, TX. Departments of Dermatology and Family Practice, University of Texas Southwestern Medical School, Dallas, TX. Dermatology Treatment and Research Center, Dallas, TX. eng Journal Article Randomized Controlled Trial 2017 02 01 United States Skinmed 101168327 1540-9740 0 Aminopyridines 0 Anti-Bacterial Agents 0 Ointments 0 Quinolones V0LH498RFO ozenoxacin IM Administration, Topical Adult Aminopyridines therapeutic use Anti-Bacterial Agents (...) Ozenoxacin Cream, 1% - Topical Treatment of Impetigo. 28270312 2019 07 08 2019 07 08 1540-9740 15 1 2017 Skinmed Skinmed Ozenoxacin Cream, 1% - Topical Treatment of Impetigo. 57-59 Gupta Aditya K AK Department of Medicine, University of Toronto School of Medicine, Toronto, Ontario, Canada, Dallas, TX; agupta@execulink.com. Mediprobe Research Inc., London, Ontario, Canada, Dallas, TX. Versteeg Sarah G SG Mediprobe Research Inc., London, Ontario, Canada, Dallas, TX. Abramovits William W

2019 Skinmed Controlled trial quality: uncertain

159. Topical estradiol increases epidermal thickness and dermal collagen of foreskin prior to hypospadia surgery - Randomized double blinded controlled trial. (Abstract)

effects in epidermal thickness and collagen distribution of estradiol compared to testosterone and placebo in skin of prepuce before hypospadia surgery.Patients were randomized into three groups according to the topical hormone used: TG: Testosterone ointment; EG: Estradiol ointment; CG: Neutral base ointment. Fragments of foreskin were excised, fixed and then sectioned for histology. For each sample, epidermal thickness and dermal collagen expression was measured by specific computer analysis, P (...) Topical estradiol increases epidermal thickness and dermal collagen of foreskin prior to hypospadia surgery - Randomized double blinded controlled trial. The use of preoperative topical testosterone stimulation prior to hypospadias correction aims to increase penile size and achieve better surgical results. Topical estradiol has been shown to improve the quality of skin in other sites, but its use in boys with hypospadia has not yet been elucidated.This study aims to evaluate the primary

2019 Journal of pediatric urology Controlled trial quality: uncertain

160. Topical Nifedipine for the Treatment of Pressure Ulcer: A Randomized, Placebo-Controlled Clinical Trial. (Abstract)

Topical Nifedipine for the Treatment of Pressure Ulcer: A Randomized, Placebo-Controlled Clinical Trial. Effect of nifedipine on pressure ulcer (PU) healing has not been evaluated in the human subjects yet.In this study, the effect of topical application of nifedipine 3% ointment on PU healing in critically ill patients was investigated.This was a randomized, double-blind, placebo-controlled clinical.In this study, 200 patients with stage I or II PU according to 2-digit Stirling Pressure Ulcer (...) Severity Scale were randomized to receive topical nifedipine 3% ointment or placebo twice daily for 14 days. Changes in the size and stage of the ulcers were considered as primary outcome of the study. The stage of the ulcers at baseline and on day 7 and day 14 of study was determined by using 2-digit stirling scale. In addition, the surface area of the wounds was estimated by multiplying width by length.In total, 83 patients in each group completed the study. The groups were matched for the baseline

2019 American journal of therapeutics Controlled trial quality: predicted high

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