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Topical Ointment

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141. Dressings and topical agents for arterial leg ulcers. (PubMed)

Dressings and topical agents for arterial leg ulcers. It is estimated that people in industrialised countries have a 1% chance of suffering from a leg ulcer at some time in their life. The majority of leg ulcers are associated with circulation problems; poor blood return in the veins causes venous ulcers (around 70% of ulcers) and poor blood supply to the legs causes arterial ulcers (around 22% of ulcers). Treatment of arterial leg ulcers is directed towards correcting the poor arterial blood (...) supply, for example by correcting arterial blockages (either surgically or pharmaceutically). If the blood supply has been restored, these arterial ulcers can heal following principles of good wound care. Dressings and topical agents make up a part of good wound care for arterial ulcers but there are many products available and it is unclear what impact these have on ulcer healing. This is an update of a review first published in 2003.To determine whether topical agents and wound dressings affect

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2015 Cochrane

142. Topical tacrolimus for atopic dermatitis. (PubMed)

Topical tacrolimus for atopic dermatitis. Atopic dermatitis (AD) (or atopic eczema) is a chronic inflammatory skin condition that affects children and adults and has an important impact on quality of life. Topical corticosteroids (TCS) are the first-line therapy for this condition; however, they can be associated with significant adverse effects when used chronically. Tacrolimus ointment (in its 2 manufactured strengths of 0.1% and 0.03%) might be an alternative treatment. Tacrolimus, together (...) with pimecrolimus, are drugs called topical calcineurin inhibitors (TCIs).To assess the efficacy and safety of topical tacrolimus for moderate and severe atopic dermatitis compared with other active treatments.We searched the following databases up to 3 June 2015: the Cochrane Skin Group Specialised Register, CENTRAL in the Cochrane Library (Issue 5, 2015), MEDLINE (from 1946), EMBASE (from 1974), LILACS (from 1982), and the Global Resource of Eczema Trials (GREAT database). We searched six trials registers

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2015 Cochrane

143. Topical corticosteroids for treating phimosis in boys. (PubMed)

Topical corticosteroids for treating phimosis in boys. Until recently, phimosis has been treated surgically by circumcision or prepuceplasty; however, recent reports of non-invasive treatment using topical corticosteroids applied for four to eight weeks have been favourable. The efficacy and safety of topical corticosteroids for treating phimosis in boys has not been previously systematically reviewed.We aimed to 1) compare the effectiveness of the use of topical corticosteroid ointment applied (...) to this review. Date of last search: 16 June 2014.We included all randomised controlled trials (RCTs) that compared use of any topical corticosteroid ointment with placebo ointment or no treatment for boys with phimosis.Two authors independently assessed titles, abstracts and the full-text of eligible studies, extracted data relating to the review's primary and secondary outcomes, and assessed studies' risk of bias. Statistical analyses were performed using the random-effects model and results were expressed

2014 Cochrane

144. Topical antifungal treatments for tinea cruris and tinea corporis. (PubMed)

also provide similar clinical and mycological cure rates, particularly azoles although most were evaluated in single studies.There is insufficient evidence to determine if Whitfield's ointment, a widely used agent is effective.Although combinations of topical steroids and antifungals are not currently recommended in any clinical guidelines, relevant studies included in this review reported higher clinical cure rates with similar mycological cure rates at the end of treatment, but the quality (...) Topical antifungal treatments for tinea cruris and tinea corporis. Tinea infections are fungal infections of the skin caused by dermatophytes. It is estimated that 10% to 20% of the world population is affected by fungal skin infections. Sites of infection vary according to geographical location, the organism involved, and environmental and cultural differences. Both tinea corporis, also referred to as 'ringworm' and tinea cruris or 'jock itch' are conditions frequently seen by primary care

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2014 Cochrane

145. External genital and perianal warts: green tea (Camellia sinensis) leaf extract 10% ointment

summaries of product characteristics (SPCs), British national formulary (BNF) or the MHRA or NICE websites for up-to-date information. Summary Green tea (Camellia sinensis) leaf extract 10% ointment (Catephen) is a self-administered topical treatment for external genital and perianal warts. In 2 randomised controlled trials (RCTs) involving a total of 1005 adults, green tea leaf extract 10% ointment was 2-fold more effective than vehicle (placebo) ointment in terms of complete clearance of all baseline (...) with the person. There are 3 self-administered topical treatment options for external genital and perianal warts. All can cause local skin reactions. The maximum treatment duration for green tea leaf extract ointment is 16 weeks, with application 3 times a day. The maximum duration ranges from 4 to 5 weeks for podophyllotoxin preparations to 16 weeks for imiquimod 5% cream. These treatments require less frequent administration than green tea leaf extract ointment. These 3 treatments are available in a variety

2015 National Institute for Health and Clinical Excellence - Advice

146. Ping On, An Herbal Ointment, May Be More Effective Than Placebo For Reducing Pain And Severity Of TMD Pain In Adult Patients

Ping On, An Herbal Ointment, May Be More Effective Than Placebo For Reducing Pain And Severity Of TMD Pain In Adult Patients UTCAT2273, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Ping On, An Herbal Ointment, May Be More Effective Than Placebo For Reducing Pain And Severity Of TMD Pain In Adult Patients Clinical Question In an adult patient with TMD, are herbal remedies more effective than placebo in reducing (...) the severity or duration of pain? Clinical Bottom Line Ping On, an herbal ointment, may be more effective than placebo for reducing pain and severity of TMD pain in adult patients. Other herbal treatment would need additional investigation. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Li/2009 Patients with TMJ and/ or masticatory pain Double Blind Randomized Control Trial Key results Ping On ointment

2012 UTHSCSA Dental School CAT Library

147. Green tea leaf extract (Veregen) - an aggressive topical treatment for anogenital warts

In patients with troublesome anogenital wart s, who are able and willing to apply a topical treatment themselves, ointment containing green tea leaf extract has no demonstrated advantages in terms of efficacy, adverse effects or convenience over topical treatments containing imiquimod or podophyllotoxin. In practice , it is better to choose the better established drugs imiquimod or podophyllotoxin. Full text available for free download. ©Prescrire 1 April 2015 Download the full review See also (...) Green tea leaf extract (Veregen) - an aggressive topical treatment for anogenital warts Prescrire IN ENGLISH - Spotlight ''In the April issue of Prescrire International: Green tea leaf extract (Veregen°) - an aggressive topical treatment for anogenital warts'', 1 April 2015 {1} {1} {1} | | > > > In the April issue of Prescrire International: Green tea leaf extract (Veregen°) - an aggressive topical treatment for anogenital warts Spotlight Every month, the subjects in Prescrire’s Spotlight. 100

2015 Prescrire

148. Topical Nitroglycerin for Peripheral Circulation and Wound Healing in the Elderly

with peripheral vascular disease Intervention Topical nitroglycerin (e.g., ointment, paste, patches) Comparator ? Placebo or no treatment ? No comparator Outcomes Q1: Clinical effectiveness: ? Benefits (e.g., increased circulation, wound healing) ? Harms (e.g., hypotension, falls, localized skin sensitivity) Q2: Evidence-based guidelines Study Designs Health technology assessments, systematic reviews, meta-analyses, randomized controlled trials, non-randomized studies, evidence-based guidelines RESULTS Rapid (...) action on thrombophlebitis induced by sclerosis of leg varicose veins. Angiology. 1994 May;45(5):347-51. PubMed: PM8172381 6. Fischer M, Reinhold B, Falck H, Torok M, Alexander K. Topical nitroglycerin ointment in Raynaud's phenomenon. Z Kardiol. 1985 May;74(5):298-302. PubMed: PM3925656 7. Franks AG, Jr. Topical glyceryl trinitrate as adjunctive treatment in Raynaud's disease. Lancet. 1982 Jan 9;1(8263):76-7. PubMed: PM6119495 Non-Randomized Studies Unclear Population Age 8. Anderson ME, Moore TL

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

149. Do any topical agents help prevent or reduce stretch marks?

Do any topical agents help prevent or reduce stretch marks? Do any topical agents help prevent or reduce stretch marks? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Do any topical agents help prevent or reduce stretch marks? View/ Open Date 2012-12 Format Metadata Abstract No topical agent has been proven to prevent (...) or reduce stretch marks. Randomized controlled trials (RCTs) show that cocoa butter doesn't prevent stretch marks (strength of recommendation [SOR]: A, 2 RCTs); neither does olive oil (SOR: B, 1 small RCT). A cream containing Centella asiatica extract, vitamin E, and collagen hydrolysates doesn't prevent new stretch marks but might avoid additional stretch marks in women who had already developed them during puberty. Massage with vitamin E ointment alone may reduce the number of stretch marks (SOR: C, 2

2014 Clinical Inquiries

150. Corticosteroids - topical (skin), nose, and eyes

and Minims®). Fluorometholone (ophthalmic suspension). Hydrocortisone acetate (drops and ointment). Loteprednol etabonate (ophthalmic suspension). Prednisolone (drops and Minims®). Rimexolone (drops). [ ] Management Management : covers the management of people receiving topical (skin) corticosteroids in primary care. : covers the management of people receiving intranasal corticosteroids in primary care. : covers the management of people receiving corticosteroid eye preparations. Although corticosteroid (...) not require treatment. For the application of corticosteroids and emollients together, see the section on . Table 2. Topical corticosteroids listed by potency class. Potency class Non-proprietary names and strengths Proprietary names Formulations Mild Hydrocortisone 0.1%, 0.5%, 1.0%, 2.5% Generic hydrocortisone, Dioderm®, Efcortelan®, Mildison® Cream and ointment Moderate Alclometasone dipropionate 0.05% Modrasone® Cream and ointment Betamethasone valerate 0.025% Betnovate-RD® Cream and ointment

2018 NICE Clinical Knowledge Summaries

151. Efficacy of photodynamic therapy combined with topical interventions for the treatment of actinic keratosis: a meta-analysis. (PubMed)

included. Four studies investigated a combination of PDT with imiquimod cream, three with 5-fluorouracil cream and one each with ingenol mebutate gel, tazarotene gel and calcipotriol ointment, respectively. Patients treated with a combination showed higher participant complete (RR 1.63; 95% CI 1.15-2.33; P = 0.007) and partial clearance rates (RR 1.19; 95% CI 0.84-1.67; P = 0.33). Similarly, the lesion-specific clearance was higher for PDT plus topical intervention compared to monotherapy (RR 1.48; 95 (...) Efficacy of photodynamic therapy combined with topical interventions for the treatment of actinic keratosis: a meta-analysis. Photodynamic therapy (PDT) is a highly effective treatment option for patients with actinic keratoses (AK). However, efficacy can be reduced by insufficient illumination or hyperkeratotic nature of lesions.To investigate if PDT combined with a topical intervention is superior to monotherapy in terms of efficacy and tolerability.A systematic literature research

2019 Journal of the European Academy of Dermatology and Venereology

152. Monotherapy of topical tacrolimus 0.03% in the treatment of vernal keratoconjunctivitis in the pediatric population. (PubMed)

Monotherapy of topical tacrolimus 0.03% in the treatment of vernal keratoconjunctivitis in the pediatric population. To report the results of treating children with vernal keratoconjunctivitis (VKC) using a monotherapy of topical tacrolimus 0.03%.This was a prospective, nonrandomized observational study of children newly diagnosed with VKC. The severity of the disease was graded on a 4-point scale of symptoms and signs. Patients were treated with tacrolimus 0.03% ointment and were followed (...) at 8 months, also a statistically significant reduction (P < 0.001). Four patients had to be started on steroids within the first month of treatment and were considered treatment failures. Thus, 89% of patients showed significant improvement. No participant experienced adverse effects, although some reported a transient stinging sensation.In our study cohort topical tacrolimus ointment 0.03% as a monotherapy for VKC was successful in the majority of subjects, and there was no adverse

2019 JAAPOS - Journal of the American Association for Pediatric Ophthalmology and Strabismus

153. Effect of Topical Garlic on Wound Healing and Scarring: A Clinical Trial. (PubMed)

Effect of Topical Garlic on Wound Healing and Scarring: A Clinical Trial. Historically, garlic containing compounds have been used on wounds to improve healing and ward off infection. Researchers have tested many of these ancient ointments, discovering that garlic is a common ingredient in those that are effective.To determine the efficacy of topical garlic on surgical wounds compared with Vaseline by analysis of visual analog scales and digital photograph analysis.Seventeen patients with 2 (...) skin excisions applied a 30% garlic ointment to one surgical wound and Vaseline to the other surgical wound twice daily. They were followed up at 2 weeks and 4 weeks post-op. Digital photographs were taken of the sites, and wound visual analog scales were filled out by the patient and the physician.Patients and the onsite physician stated the garlic site healed better in 59% and 65% of the wounds, respectively, at 2 weeks. At 4 weeks, the patients and the onsite physician stated the garlic site

2019 Dermatologic Surgery

154. Efficacy and safety of topical delgocitinib in patients with chronic hand eczema: data from a randomised, double-blind, vehicle-controlled Phase 2a study. (PubMed)

Efficacy and safety of topical delgocitinib in patients with chronic hand eczema: data from a randomised, double-blind, vehicle-controlled Phase 2a study. Management of chronic hand eczema (CHE) remains a challenge; effective topical treatment is still limited to corticosteroids.In this vehicle-controlled study, the efficacy/safety of a novel, pan-JAK inhibitor (delgocitinib) were assessed in patients with CHE.In this randomised, double-blind, Phase 2a study, patients with CHE received (...) delgocitinib ointment 30 mg/g or vehicle ointment for 8 weeks. The primary endpoint was the proportion of patients achieving treatment success ('clear'/'almost clear' skin with ≥2-point improvement in the Physician's Global Assessment of disease severity [PGA]) at Week 8. Secondary endpoints included Hand Eczema Severity Index (HECSI) score changes and the proportion of patients achieving treatment success on the Patient's Global Assessment of disease severity (PaGA).Ninety-one patients were randomised

2019 British Journal of Dermatology Controlled trial quality: predicted high

155. Topical morphine for treatment of cancer-related painful mucosal and cutaneous lesions: a double-blind, placebo-controlled cross-over clinical trial. (PubMed)

the effectiveness and safety of topical morphine for pain related to mucosal lesions and skin ulcers.The study was a 14-day randomized placebo-controlled cross-over trial (RCT) with a 28-day follow-up open phase (OP). The trial was conducted in adult patients with localized cancer-related pain and treated with systemic opioids in an oncology center or home hospice. The patients administered 0.2% gel on the mucosal lesion or 0.2% ointment on the skin lesion by themselves, without restrictions regarding (...) Topical morphine for treatment of cancer-related painful mucosal and cutaneous lesions: a double-blind, placebo-controlled cross-over clinical trial. Painful mucosal and cutaneous lesions are often less responsive or even refractory to systemic opioid analgesics. There is evidence suggesting that the effectiveness of topical morphine be restricted to inflammatory pain. The studied groups were small and the observation period relatively short. The aim of this study was to assess

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2019 Archives of medical science : AMS Controlled trial quality: uncertain

156. Treatment with silver nitrate versus topical steroid treatment for umbilical granuloma: A non-inferiority randomized control trial. (PubMed)

Treatment with silver nitrate versus topical steroid treatment for umbilical granuloma: A non-inferiority randomized control trial. The aim of this prospective multicenter randomized controlled trial was to compare the efficacy of silver nitrate cauterization against that of topical steroid ointment in the treatment of neonatal umbilical granuloma.An open-label, non-inferiority randomized controlled trial was conducted from January 2013 to January 2016. The primary endpoint for the silver (...) nitrate cauterization and topical steroid ointment groups was the healing rate after 2 weeks of treatment, applying a non-inferiority margin of 10%. The healing rate was evaluated until completion of 3 weeks of treatment.Participants comprised 207 neonates with newly diagnosed umbilical granuloma, randomized to receive silver nitrate cauterization (n = 104) or topical steroid ointment (n = 103). Healing rates after 2 weeks of treatment were 87.5% (91/104) in the silver nitrate cauterization and 82

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2018 PLoS ONE Controlled trial quality: uncertain

157. Effect of Vitamin E Ointment on Incisional SSI in Colorectal Surgery

2015 Actual Primary Completion Date : March 2016 Actual Study Completion Date : March 2016 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Vitamin E ointment application Before the skin stapling and after the subcutaneous irrigation with normal saline, sterile Vitamin E acetate ointment was applied in the subcutaneous tissue; 2 ml were applied in the suprapubic incision and 0.5 ml (...) Effect of Vitamin E Ointment on Incisional SSI in Colorectal Surgery Effect of Vitamin E Ointment on Incisional SSI in Colorectal Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect of Vitamin E

2016 Clinical Trials

158. Efficacy and Safety of VDA-1102 Ointment in the Treatment of Actinic Keratosis

, Placebo-Controlled, Parallel-Cohort Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Once-Daily Application of Topical VDA-1102 Ointment for 28 Days in Subjects With Actinic Keratosis Actual Study Start Date : July 2016 Actual Primary Completion Date : May 2017 Actual Study Completion Date : May 2017 Resource links provided by the National Library of Medicine resources: Arms and Interventions Go to Arm Intervention/treatment Placebo Comparator: Placebo Drug: Placebo 200 mg (...) applied once-daily for 28 days Other Names: Excipients alone Matched-placebo Experimental: 5% VDA-1102 Drug: 5% VDA-1102 200 mg applied once-daily for 28 days Other Name: 5% VDA-1102 topical dermal ointment Experimental: 10% VDA-1102 Drug: 10% VDA-1102 200 mg applied once-daily for 28 days Other Name: 10% VDA-1102 topical dermal ointment Outcome Measures Go to Primary Outcome Measures : Number of actinic keratosis lesions in the Treatment Field [ Time Frame: 56 days ] Secondary Outcome Measures

2016 Clinical Trials

159. Trial on Efficacy and Safety of Pritelivir Ointment for Treatment of Labial Herpes

Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Pritelivir 5% w/w ointment Topical treatment (20 applications), 5 times daily for 4 days Drug: Pritelivir 5% w/w ointment Placebo Comparator: Pritelivir ointment matching placebo Topical treatment (20 applications), 5 times daily for 4 days Drug: Pritelivir ointment matching placebo Active Comparator: Zovirax® cream Topical treatment (20 applications), 5 times daily for 4 days Drug (...) Trial on Efficacy and Safety of Pritelivir Ointment for Treatment of Labial Herpes Trial on Efficacy and Safety of Pritelivir Ointment for Treatment of Labial Herpes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2016 Clinical Trials

160. Trial to Assess the Potency of SOR007 Ointment in a Psoriasis Plaque Test

. Information provided by (Responsible Party): DFB Soria, LLC Study Details Study Description Go to Brief Summary: Evaluation of safety, pharmacokinetics, and anti-psoriatic efficacy to assess SOR007 Ointment in topical formulations Condition or disease Intervention/treatment Phase Plaque Psoriasis Drug: SOR007 Ointment 2.0% Drug: SOR007 Ointment 1.0% Drug: SOR007 Ointment 0.3% Drug: SOR007 Ointment 0.15% Drug: SOR007 Ointment Placebo Drug: Taclonex® Ointment Phase 1 Detailed Description: This is a two (...) -center, randomized, placebo- and active comparator-controlled trial that will be double-blind for the investigational products (IPs) and observer-blind for the active comparator with intra-individual comparison of treatments. Twelve male and post-menopausal female volunteer subjects, aged 18 years or older, with psoriasis vulgaris and mild or moderate chronic plaque(s) in a stable phase and an area sufficient for six treatment fields, will be enrolled. SOR007 Ointment will be administered topically

2016 Clinical Trials

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