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Topical Ointment

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121. Efficacy of Twice Daily Application of LEO 124249 Ointment 30 mg/g for 12 Weeks on Eyebrow Alopecia Areata.

topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: LEO 124249 ointment 30 mg/g Ointment to be applied on the eyebrow twice daily. Drug: LEO 124249 Ointment containing LEO 124249 Placebo Comparator: LEO 124249 ointment vehicle Ointment to be applied on the eyebrow twice daily. Other: Ointment vehicle Ointment without active ingredients Outcome Measures Go to Primary Outcome Measures : Change from baseline to week 12 of investigator evaluated overall area score (ASoverall L+R (...) Efficacy of Twice Daily Application of LEO 124249 Ointment 30 mg/g for 12 Weeks on Eyebrow Alopecia Areata. Efficacy of Twice Daily Application of LEO 124249 Ointment 30 mg/g for 12 Weeks on Eyebrow Alopecia Areata. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2017 Clinical Trials

122. Study of SOR007 Ointment for Cervical Intraepithelial Neoplasia (CIN)

provided by (Responsible Party): DFB Soria, LLC Study Details Study Description Go to Brief Summary: This is a Phase 2, open-label, dose-rising study evaluating the safety, tolerability, and preliminary efficacy of three concentrations of SOR007 ointment (0.15%, 1.0%, and 2.0%) applied topically once per week for four weeks to the ectocervix of subjects with high grade cervical intraepithelial neoplasia (CIN). Condition or disease Intervention/treatment Phase Cervical Intraepithelial Neoplasia Drug (...) : SOR007 (Uncoated Nanoparticulate Paclitaxel) Ointment Phase 2 Detailed Description: In this Phase 2, open-label, dose-rising study, subjects with high grade (CIN 2 or 3) CIN will receive once-weekly topical application of SOR007 ointment to the ectocervix for four weeks. Subjects will be enrolled in three dose-escalating cohorts of three subjects assigned consecutively to receive 0.15%, 1.0%, or 2.0% SOR007 ointment. At the final study visit (Visit 7) subjects will undergo an excision or punch biopsy

2017 Clinical Trials

123. Efficacy and Safety of a 0.1% Tacrolimus Nasal Ointment as a Treatment for Epistaxis in Hemorrhagic Hereditary Telangiectasia (HHT)

and can therefore readily be used as it is for nasal administration. Topical nasal administration of tacrolimus may be an easy local ENT treatment that is non-aggressive and results in little trauma for the patient in relation to other first line treatment possibilities. The main objective of this trial is to evaluate, at 6 weeks after the end of the treatment, the efficacy on the duration of nosebleeds, of 6 weeks tacrolimus nasal ointment application, in patients with HHT complicated by nosebleeds (...) Efficacy and Safety of a 0.1% Tacrolimus Nasal Ointment as a Treatment for Epistaxis in Hemorrhagic Hereditary Telangiectasia (HHT) Efficacy and Safety of a 0.1% Tacrolimus Nasal Ointment as a Treatment for Epistaxis in Hemorrhagic Hereditary Telangiectasia (HHT) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have

2017 Clinical Trials

124. The Effect of Lithospermum officinale, Silver Sulfadiazine and Alpha Ointments in Healing of Burn Wound Injuries in Rat (PubMed)

and alpha ointment were used after burn injury.It can be concluded that topical application of L. officinale as a non-toxic, inexpensive and easy to produce herbal can lead to a rapid epithelialization and wound healing and these findings can be added to the literature on burn wound healing. (...) The Effect of Lithospermum officinale, Silver Sulfadiazine and Alpha Ointments in Healing of Burn Wound Injuries in Rat Burn is the most devastating condition in emergency medicine leading to chronic disabilities. This study aimed to compare the effect of Lithospermum officinale, silver sulfadiazine and alpha ointments on healing of burn wounds in rat.Ninety-five rats were divided into 5 groups. Group 1 just underwent burn injury, and groups 2-5 received alpha ointment, silver sulfadiazine (SSD

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2017 World journal of plastic surgery

125. Nasal application of petrolatum ointment - A silent cause of exogenous lipoid pneumonia: Successfully treated with prednisolone (PubMed)

patients who become clinically unstable or an abnormal lung shadow or during evaluation of rhinobronchial allergy. It is rarely reported from chronic use of petrolatum ointment extranasally and was diagnosed by transbronchial biopsy in the present case. She was found, retrospectively, to have been using petrolatum ointment, as an extranasal application since more than a year at bedtime. She didn't give history of using any other oil-based nasal topical vasoconstrictor preparations for sinusitis. Our (...) Nasal application of petrolatum ointment - A silent cause of exogenous lipoid pneumonia: Successfully treated with prednisolone We report a case of exogenous lipoid pneumonia from chronic, extranasal use of petrolatum ointment (Vicks VapoRub in this case) for nasal decongestion in a young woman, presenting with cough, dyspnea and fever. Exogenous Lipoid pneumonia is a rare condition, underdiagnosed and is more prevalent in adults. Usually asymptomatic and diagnosed while evaluating predisposed

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2017 Respiratory Medicine Case Reports

126. Sirolimus Ointment for Facial Angiofibromas in Individuals with Tuberous Sclerosis Complex (PubMed)

Sirolimus Ointment for Facial Angiofibromas in Individuals with Tuberous Sclerosis Complex Background. Facial angiofibromas affect most patients with tuberous sclerosis complex. They tend to progress, can cause recurrent bleeding and facial disfigurement, and have significant psychological effects. We reviewed the effectiveness and safety of topical sirolimus ointment 0.1%. We also assessed the effect of treatment on quality of life. Methods. We report our experience in using sirolimus ointment (...) in 14 patients with TSC (9 children and 5 adults). The impact of sirolimus ointment was monitored with digital photography, dermatological review using a validated Facial Angiofibroma Severity Index (FASI), and quality of life assessments using the questionnaires PedsQL for children and SF36 for adults. Results. The FASI scores were improved in 12/14 cases after six months' treatment, and improvement was more likely in children (median FASI scores of improvement after treatment were 3 points

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2017 International scholarly research notices

127. Efficacy and safety of tacrolimus ointment 0.03% treatment in a 1-month-old "red baby": a case report. (PubMed)

Efficacy and safety of tacrolimus ointment 0.03% treatment in a 1-month-old "red baby": a case report. Several trials have indicated that topical tacrolimus is safe and effective for several immunologic-based skin disorders. We report a child <2 months old, who was admitted to our pediatric department because of generalized erythroderma. We started tacrolimus ointment 0.03% therapy by applying the ointment to the skin once daily, on a limited surface of 10 cm(2), changing the skin areas only (...) to the treatment was good. We conclude that 0.03% tacrolimus ointment is efficacious and safe even in an infant <2 months of age.

2017 Allergy and Asthma Proceedings

128. Topical Tacrolimus is equally effective in treating patients with Oral Lichen Planus (OLP) as compared to Topical clobetasol

into 2 groups: twenty patients were assigned the use of clobetasol propionate (0.05%) ointment (topical corticosteroid) twenty patients were assigned the use of tacrolimus (0.1%) ointment (topical immunosuppressant), for eight weeks each. The patients were instructed to apply the ointment twice a day during the treatment period. Both groups were additionally instructed to use chlorhexidine mouthwash three times per day during the 8 week period. All patients were assessed at 2 weeks, 4 weeks and 8 (...) group, and 81.6% in the clobetasol group. VAS scores after 6 weeks of treatment suggested improvement (p #3) Corrocher /2008 n= 32 RCT Key results This study recruited 32 patients with histologically confirmed OLP. Patients were randomly assigned to two treatment groups; sixteen patients received 2ml of tacrolimus 0.1% ointment, and sixteen patients received 2ml of clobetasol propionate 0.05% ointment. Both groups were instructed to apply the topical medication four times daily for 4 weeks. Patients

2013 UTHSCSA Dental School CAT Library

129. Evaluation of the bacterial ocular surface microbiome in clinically normal horses before and after treatment with topical neomycin-polymyxin-bacitracin. (PubMed)

of the ocular surface microbiome in healthy horses, and to identify whether there are microbial community changes over time and following topical antibiotic use. One eye of 12 horses was treated 3 times daily for 1 week with neomycin-polymyxin-bacitracin ophthalmic ointment. Contralateral eyes served as untreated controls. The inferior conjunctival fornix of both eyes was sampled at baseline prior to initiating treatment (day 0), after 1 week of treatment (day 7), and 4 weeks after concluding treatment (day (...) Evaluation of the bacterial ocular surface microbiome in clinically normal horses before and after treatment with topical neomycin-polymyxin-bacitracin. Next generation sequencing (NGS) studies have demonstrated a rich and diverse ocular surface-associated microbiota in people that was previously undetected by traditional culture-based methods. The ocular surface microbiome of horses has yet to be investigated using NGS techniques. This study aimed to determine the bacterial composition

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2019 PLoS ONE

130. Dressings and topical agents for arterial leg ulcers. (PubMed)

Dressings and topical agents for arterial leg ulcers. It is estimated that people in industrialised countries have a 1% chance of suffering from a leg ulcer at some time in their life. The majority of leg ulcers are associated with circulation problems; poor blood return in the veins causes venous ulcers (around 70% of ulcers) and poor blood supply to the legs causes arterial ulcers (around 22% of ulcers). Treatment of arterial leg ulcers is directed towards correcting the poor arterial blood (...) supply, for example by correcting arterial blockages (either surgically or pharmaceutically). If the blood supply has been restored, these arterial ulcers can heal following principles of good wound care. Dressings and topical agents make up a part of good wound care for arterial ulcers but there are many products available and it is unclear what impact these have on ulcer healing. This is an update of a review first published in 2003.To determine whether topical agents and wound dressings affect

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2015 Cochrane

131. Topical tacrolimus for atopic dermatitis. (PubMed)

Topical tacrolimus for atopic dermatitis. Atopic dermatitis (AD) (or atopic eczema) is a chronic inflammatory skin condition that affects children and adults and has an important impact on quality of life. Topical corticosteroids (TCS) are the first-line therapy for this condition; however, they can be associated with significant adverse effects when used chronically. Tacrolimus ointment (in its 2 manufactured strengths of 0.1% and 0.03%) might be an alternative treatment. Tacrolimus, together (...) with pimecrolimus, are drugs called topical calcineurin inhibitors (TCIs).To assess the efficacy and safety of topical tacrolimus for moderate and severe atopic dermatitis compared with other active treatments.We searched the following databases up to 3 June 2015: the Cochrane Skin Group Specialised Register, CENTRAL in the Cochrane Library (Issue 5, 2015), MEDLINE (from 1946), EMBASE (from 1974), LILACS (from 1982), and the Global Resource of Eczema Trials (GREAT database). We searched six trials registers

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2015 Cochrane

132. Topical corticosteroids for treating phimosis in boys. (PubMed)

Topical corticosteroids for treating phimosis in boys. Until recently, phimosis has been treated surgically by circumcision or prepuceplasty; however, recent reports of non-invasive treatment using topical corticosteroids applied for four to eight weeks have been favourable. The efficacy and safety of topical corticosteroids for treating phimosis in boys has not been previously systematically reviewed.We aimed to 1) compare the effectiveness of the use of topical corticosteroid ointment applied (...) to this review. Date of last search: 16 June 2014.We included all randomised controlled trials (RCTs) that compared use of any topical corticosteroid ointment with placebo ointment or no treatment for boys with phimosis.Two authors independently assessed titles, abstracts and the full-text of eligible studies, extracted data relating to the review's primary and secondary outcomes, and assessed studies' risk of bias. Statistical analyses were performed using the random-effects model and results were expressed

2014 Cochrane

133. Topical antifungal treatments for tinea cruris and tinea corporis. (PubMed)

also provide similar clinical and mycological cure rates, particularly azoles although most were evaluated in single studies.There is insufficient evidence to determine if Whitfield's ointment, a widely used agent is effective.Although combinations of topical steroids and antifungals are not currently recommended in any clinical guidelines, relevant studies included in this review reported higher clinical cure rates with similar mycological cure rates at the end of treatment, but the quality (...) Topical antifungal treatments for tinea cruris and tinea corporis. Tinea infections are fungal infections of the skin caused by dermatophytes. It is estimated that 10% to 20% of the world population is affected by fungal skin infections. Sites of infection vary according to geographical location, the organism involved, and environmental and cultural differences. Both tinea corporis, also referred to as 'ringworm' and tinea cruris or 'jock itch' are conditions frequently seen by primary care

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2014 Cochrane

134. External genital and perianal warts: green tea (Camellia sinensis) leaf extract 10% ointment

summaries of product characteristics (SPCs), British national formulary (BNF) or the MHRA or NICE websites for up-to-date information. Summary Green tea (Camellia sinensis) leaf extract 10% ointment (Catephen) is a self-administered topical treatment for external genital and perianal warts. In 2 randomised controlled trials (RCTs) involving a total of 1005 adults, green tea leaf extract 10% ointment was 2-fold more effective than vehicle (placebo) ointment in terms of complete clearance of all baseline (...) with the person. There are 3 self-administered topical treatment options for external genital and perianal warts. All can cause local skin reactions. The maximum treatment duration for green tea leaf extract ointment is 16 weeks, with application 3 times a day. The maximum duration ranges from 4 to 5 weeks for podophyllotoxin preparations to 16 weeks for imiquimod 5% cream. These treatments require less frequent administration than green tea leaf extract ointment. These 3 treatments are available in a variety

2015 National Institute for Health and Clinical Excellence - Advice

135. Ping On, An Herbal Ointment, May Be More Effective Than Placebo For Reducing Pain And Severity Of TMD Pain In Adult Patients

Ping On, An Herbal Ointment, May Be More Effective Than Placebo For Reducing Pain And Severity Of TMD Pain In Adult Patients UTCAT2273, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Ping On, An Herbal Ointment, May Be More Effective Than Placebo For Reducing Pain And Severity Of TMD Pain In Adult Patients Clinical Question In an adult patient with TMD, are herbal remedies more effective than placebo in reducing (...) the severity or duration of pain? Clinical Bottom Line Ping On, an herbal ointment, may be more effective than placebo for reducing pain and severity of TMD pain in adult patients. Other herbal treatment would need additional investigation. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Li/2009 Patients with TMJ and/ or masticatory pain Double Blind Randomized Control Trial Key results Ping On ointment

2012 UTHSCSA Dental School CAT Library

136. Green tea leaf extract (Veregen) - an aggressive topical treatment for anogenital warts

In patients with troublesome anogenital wart s, who are able and willing to apply a topical treatment themselves, ointment containing green tea leaf extract has no demonstrated advantages in terms of efficacy, adverse effects or convenience over topical treatments containing imiquimod or podophyllotoxin. In practice , it is better to choose the better established drugs imiquimod or podophyllotoxin. Full text available for free download. ©Prescrire 1 April 2015 Download the full review See also (...) Green tea leaf extract (Veregen) - an aggressive topical treatment for anogenital warts Prescrire IN ENGLISH - Spotlight ''In the April issue of Prescrire International: Green tea leaf extract (Veregen°) - an aggressive topical treatment for anogenital warts'', 1 April 2015 {1} {1} {1} | | > > > In the April issue of Prescrire International: Green tea leaf extract (Veregen°) - an aggressive topical treatment for anogenital warts Spotlight Every month, the subjects in Prescrire’s Spotlight. 100

2015 Prescrire

137. Do any topical agents help prevent or reduce stretch marks?

Do any topical agents help prevent or reduce stretch marks? Do any topical agents help prevent or reduce stretch marks? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Do any topical agents help prevent or reduce stretch marks? View/ Open Date 2012-12 Format Metadata Abstract No topical agent has been proven to prevent (...) or reduce stretch marks. Randomized controlled trials (RCTs) show that cocoa butter doesn't prevent stretch marks (strength of recommendation [SOR]: A, 2 RCTs); neither does olive oil (SOR: B, 1 small RCT). A cream containing Centella asiatica extract, vitamin E, and collagen hydrolysates doesn't prevent new stretch marks but might avoid additional stretch marks in women who had already developed them during puberty. Massage with vitamin E ointment alone may reduce the number of stretch marks (SOR: C, 2

2014 Clinical Inquiries

138. Effect of Vitamin E Ointment on Incisional SSI in Colorectal Surgery

2015 Actual Primary Completion Date : March 2016 Actual Study Completion Date : March 2016 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Vitamin E ointment application Before the skin stapling and after the subcutaneous irrigation with normal saline, sterile Vitamin E acetate ointment was applied in the subcutaneous tissue; 2 ml were applied in the suprapubic incision and 0.5 ml (...) Effect of Vitamin E Ointment on Incisional SSI in Colorectal Surgery Effect of Vitamin E Ointment on Incisional SSI in Colorectal Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect of Vitamin E

2016 Clinical Trials

139. Efficacy and Safety of VDA-1102 Ointment in the Treatment of Actinic Keratosis

, Placebo-Controlled, Parallel-Cohort Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Once-Daily Application of Topical VDA-1102 Ointment for 28 Days in Subjects With Actinic Keratosis Actual Study Start Date : July 2016 Actual Primary Completion Date : May 2017 Actual Study Completion Date : May 2017 Resource links provided by the National Library of Medicine resources: Arms and Interventions Go to Arm Intervention/treatment Placebo Comparator: Placebo Drug: Placebo 200 mg (...) applied once-daily for 28 days Other Names: Excipients alone Matched-placebo Experimental: 5% VDA-1102 Drug: 5% VDA-1102 200 mg applied once-daily for 28 days Other Name: 5% VDA-1102 topical dermal ointment Experimental: 10% VDA-1102 Drug: 10% VDA-1102 200 mg applied once-daily for 28 days Other Name: 10% VDA-1102 topical dermal ointment Outcome Measures Go to Primary Outcome Measures : Number of actinic keratosis lesions in the Treatment Field [ Time Frame: 56 days ] Secondary Outcome Measures

2016 Clinical Trials

140. Trial on Efficacy and Safety of Pritelivir Ointment for Treatment of Labial Herpes

Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Pritelivir 5% w/w ointment Topical treatment (20 applications), 5 times daily for 4 days Drug: Pritelivir 5% w/w ointment Placebo Comparator: Pritelivir ointment matching placebo Topical treatment (20 applications), 5 times daily for 4 days Drug: Pritelivir ointment matching placebo Active Comparator: Zovirax® cream Topical treatment (20 applications), 5 times daily for 4 days Drug (...) Trial on Efficacy and Safety of Pritelivir Ointment for Treatment of Labial Herpes Trial on Efficacy and Safety of Pritelivir Ointment for Treatment of Labial Herpes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2016 Clinical Trials

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