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Topical Ointment

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121. Percutaneous Posterior Tibial Nerve Stimulation vs Perianal Application of Glyceryl Trinitrate Ointment in the Treatment of Chronic Anal Fissure: A Randomized Clinical Trial. (PubMed)

Percutaneous Posterior Tibial Nerve Stimulation vs Perianal Application of Glyceryl Trinitrate Ointment in the Treatment of Chronic Anal Fissure: A Randomized Clinical Trial. Current therapeutic guidelines for the treatment of chronic anal fissure establish a medical approach as the first step. Glyceryl trinitrate ointment is the most popular of the available topical treatments in Spain but it is associated with the appearance of headache.The purpose of this study was to compare the compliance (...) rate among patients receiving glyceryl trinitrate treatment for chronic anal fissure with that among patients receiving percutaneous posterior tibial nerve stimulation.This was a prospective randomized study.The study was conducted at Garcilaso Clinic (Madrid, Spain).Subjects with persistent anal fissure despite hygiene and dietary measures applied over at least a 6-week period were included.Study interventions were perianal application of glyceryl trinitrate ointment (twice daily for 8 weeks

2017 Diseases of the Colon & Rectum

122. Crisaborole Ointment 2%: A Review in Mild to Moderate Atopic Dermatitis. (PubMed)

Crisaborole Ointment 2%: A Review in Mild to Moderate Atopic Dermatitis. Crisaborole ointment 2% (Eucrisa™) is a novel, anti-inflammatory inhibitor of phosphodiesterase 4 (PDE4) that is available in the USA for the topical treatment of mild to moderate atopic dermatitis in patients aged ≥ 2 years. In two short-term (28 days), identically designed, multicentre, phase III studies in this patient population, topical therapy with crisaborole ointment 2% reduced disease severity and pruritus (...) of mild to moderate severity and considered unrelated to the study medication. Moreover, the incidence of application-site pain following short- and longer-term topical therapy with crisaborole ointment 2% was low. In conclusion, crisaborole ointment 2% is an effective and generally well tolerated new topical option for the management of mild to moderate atopic dermatitis in patients aged ≥ 2 years, with the potential to effectively treat this patient population over the longer term without the safety

2017 American journal of clinical dermatology

123. Low incidence of hypercalcemia following combined calcipotriol hydrate/betamethasone dipropionate ointment treatment in Japanese patients with severe psoriasis vulgaris. (PubMed)

Low incidence of hypercalcemia following combined calcipotriol hydrate/betamethasone dipropionate ointment treatment in Japanese patients with severe psoriasis vulgaris. Topical active vitamin D3 application alone or in combination with topical steroid application is widely used to treat psoriasis. In Japan, combined calcipotriol hydrate/betamethasone dipropionate ointment has been used for patients with psoriasis vulgaris since September 2014. Current evidence regarding the incidence (...) Ca concentration changed only marginally, from 9.04 ± 0.34 mg/dL before treatment to 9.08 ± 0.39 mg/dL after 8 weeks of treatment. None of the patients had an elevated serum Ca concentration throughout the study. No cases of hypercalcemia were reported as an adverse event. No correlation was detected between the amount of the combined calcipotriol hydrate/betamethasone dipropionate ointment applied and changes in the serum Ca concentration.The incidence of hypercalcemia due to topical application

2017 Journal of Dermatological Treatment

124. Comparison of indirubin concentrations in indigo naturalis ointment for psoriasis treatment: a randomized, double-blind, dosage-controlled trial. (PubMed)

Comparison of indirubin concentrations in indigo naturalis ointment for psoriasis treatment: a randomized, double-blind, dosage-controlled trial. Indigo naturalis and its refined formulation, Lindioil, are effective in treating psoriatic symptoms topically. Indirubin is the active ingredient in indigo naturalis.To determine the efficacy and safety of different concentrations of indirubin in Lindioil ointment for treating psoriasis.In this randomized, double-blind trial, adult patients (...) ) was the 200 μg g-1 group. No severe treatment-related adverse events were reported during the 20-week evaluation.An amount of 200 μg g-1 of indirubin in Lindioil ointment is the most effective concentration studied so far for treating psoriasis topically, and is safe.© 2017 British Association of Dermatologists.

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2017 British Journal of Dermatology

125. Clinical safety and efficacy of vitamin D3 analog ointment for treatment of obstructive meibomian gland dysfunction. (PubMed)

as BUT, meibum grade, and meibomian gland area were significantly improved in oMGD patients after the 8-week treatment period compared with pretreatment values (P values of <0.001, 0.020, 0.030, 0.020, and 0.017, respectively).Topical eyelid application of an analog of the active form of vitamin D3 was found to be safe as well as to improve the condition of patients with oMGD. Such ointment thus warrants further evaluation as a potential new treatment option for this condition.This study was registered (...) Clinical safety and efficacy of vitamin D3 analog ointment for treatment of obstructive meibomian gland dysfunction. Hyperkeratinization is a major cause of obstructive meibomian gland dysfunction (oMGD) and results in degenerative gland dilation and atrophy without inflammation. Ointment containing 1,25-dihydroxy-22-oxavitamin D3 (maxacalcitol), a noncalcemic analog of the active form of vitamin D3, is applied for the treatment of hyperkeratotic cutaneous conditions such as psoriasis

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2017 BMC Ophthalmology

126. A Study of Crisaborole Ointment 2% in Children Aged 3-24 Months With Mild to Moderate Atopic Dermatitis

OF CRISABOROLE OINTMENT 2% IN CHILDREN AGED 3 MONTHS TO LESS THAN 24 MONTHS WITH MILD TO MODERATE ATOPIC DERMATITIS Actual Study Start Date : January 16, 2018 Estimated Primary Completion Date : April 11, 2019 Estimated Study Completion Date : April 11, 2019 Resource links provided by the National Library of Medicine related topics: related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Crisaborole ointment 2% Subjects will be dosed for 28 days. A thin layer (...) A Study of Crisaborole Ointment 2% in Children Aged 3-24 Months With Mild to Moderate Atopic Dermatitis A Study of Crisaborole Ointment 2% in Children Aged 3-24 Months With Mild to Moderate Atopic Dermatitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2017 Clinical Trials

127. The Effect of Low-Dose Nitroglycerin Ointment on Skin Flap Necrosis in Breast Reconstruction after Skin-Sparing or Nipple-Sparing Mastectomy (PubMed)

The Effect of Low-Dose Nitroglycerin Ointment on Skin Flap Necrosis in Breast Reconstruction after Skin-Sparing or Nipple-Sparing Mastectomy Skin flap necrosis is a common complication after mastectomy and breast reconstruction. It has been proven that nitroglycerin ointment, as a topical vasodilator, can decrease the rate of skin flap necrosis after mastectomy and breast reconstruction. However, nitroglycerin can cause several side effects, including headache, dizziness, and hypotension (...) . The purpose of this study was to evaluate whether the application of a low dose of nitroglycerin ointment reduced the rate of skin flap necrosis in breast reconstruction after skin-sparing or nipple-sparing mastectomy.A total of 73 cases of breast reconstruction after nipple-sparing and skin-sparing mastectomy at our institution from March 2012 to January 2017 were retrospectively studied. Of these patients, 52 received nitroglycerin ointment (4.5 mg) application to the skin around the nipple-areolar

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2017 Archives of plastic surgery

128. A Study of Crisaborole Ointment 2% in Adult Japanese Healthy Subjects and Adult Japanese Subjects With Mild To Moderate Atopic Dermatitis

-controlled, Parallel-cohort Study Of Crisaborole Ointment 2% To Evaluate The Skin Irritation Potential In Adult Japanese Healthy Subjects, And To Evaluate The Safety, Tolerability And Pharmacokinetics In Adult Japanese Subjects With Mild To Moderate Atopic Dermatitis Actual Study Start Date : September 13, 2017 Actual Primary Completion Date : November 27, 2017 Actual Study Completion Date : November 27, 2017 Resource links provided by the National Library of Medicine related topics: related topics (...) A Study of Crisaborole Ointment 2% in Adult Japanese Healthy Subjects and Adult Japanese Subjects With Mild To Moderate Atopic Dermatitis A Study of Crisaborole Ointment 2% in Adult Japanese Healthy Subjects and Adult Japanese Subjects With Mild To Moderate Atopic Dermatitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study

2017 Clinical Trials

129. Efficacy Of Autologous Epidermal Cell Suspension And Silver Sulfadiazine Ointment In Burn

Efficacy Of Autologous Epidermal Cell Suspension And Silver Sulfadiazine Ointment In Burn Efficacy Of Autologous Epidermal Cell Suspension And Silver Sulfadiazine Ointment In Burn - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Efficacy Of Autologous Epidermal Cell Suspension And Silver Sulfadiazine Ointment In Burn The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03162367 Recruitment Status : Not yet recruiting First

2017 Clinical Trials

130. Crisaborole Ointment 2% Skin Biomarker Biopsy Study in Atopic Dermatitis

Study Start Date : July 31, 2017 Actual Primary Completion Date : May 4, 2018 Actual Study Completion Date : May 4, 2018 Resource links provided by the National Library of Medicine related topics: related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Crisaborole ointment Drug: Crisaborole ointment 2% BID Crisaborole ointment 2% BID for 15 days (double blind); additional 28 days (open label) Placebo Comparator: Placebo ointment (vehicle) Drug: Placebo (...) corticosteroids or systemic (oral/injectable) corticosteroids to manage AD. History of angioedema or anaphylaxis to topical products or known sensitivity to components of crisaborole ointment 2%. History of cancer (except squamous or basal cell carcinoma or carcinoma in situ of the skin). Previous treatment with any topical or systemic PDE4 inhibitor unless stopped for the reason of lack of efficacy. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study

2017 Clinical Trials

131. Efficacy of Twice Daily Application of LEO 124249 Ointment 30 mg/g for 12 Weeks on Eyebrow Alopecia Areata.

topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: LEO 124249 ointment 30 mg/g Ointment to be applied on the eyebrow twice daily. Drug: LEO 124249 Ointment containing LEO 124249 Placebo Comparator: LEO 124249 ointment vehicle Ointment to be applied on the eyebrow twice daily. Other: Ointment vehicle Ointment without active ingredients Outcome Measures Go to Primary Outcome Measures : Change from baseline to week 12 of investigator evaluated overall area score (ASoverall L+R (...) Efficacy of Twice Daily Application of LEO 124249 Ointment 30 mg/g for 12 Weeks on Eyebrow Alopecia Areata. Efficacy of Twice Daily Application of LEO 124249 Ointment 30 mg/g for 12 Weeks on Eyebrow Alopecia Areata. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2017 Clinical Trials

132. Study of SOR007 Ointment for Cervical Intraepithelial Neoplasia (CIN)

provided by (Responsible Party): DFB Soria, LLC Study Details Study Description Go to Brief Summary: This is a Phase 2, open-label, dose-rising study evaluating the safety, tolerability, and preliminary efficacy of three concentrations of SOR007 ointment (0.15%, 1.0%, and 2.0%) applied topically once per week for four weeks to the ectocervix of subjects with high grade cervical intraepithelial neoplasia (CIN). Condition or disease Intervention/treatment Phase Cervical Intraepithelial Neoplasia Drug (...) : SOR007 (Uncoated Nanoparticulate Paclitaxel) Ointment Phase 2 Detailed Description: In this Phase 2, open-label, dose-rising study, subjects with high grade (CIN 2 or 3) CIN will receive once-weekly topical application of SOR007 ointment to the ectocervix for four weeks. Subjects will be enrolled in three dose-escalating cohorts of three subjects assigned consecutively to receive 0.15%, 1.0%, or 2.0% SOR007 ointment. At the final study visit (Visit 7) subjects will undergo an excision or punch biopsy

2017 Clinical Trials

133. Efficacy and Safety of a 0.1% Tacrolimus Nasal Ointment as a Treatment for Epistaxis in Hemorrhagic Hereditary Telangiectasia (HHT)

and can therefore readily be used as it is for nasal administration. Topical nasal administration of tacrolimus may be an easy local ENT treatment that is non-aggressive and results in little trauma for the patient in relation to other first line treatment possibilities. The main objective of this trial is to evaluate, at 6 weeks after the end of the treatment, the efficacy on the duration of nosebleeds, of 6 weeks tacrolimus nasal ointment application, in patients with HHT complicated by nosebleeds (...) Efficacy and Safety of a 0.1% Tacrolimus Nasal Ointment as a Treatment for Epistaxis in Hemorrhagic Hereditary Telangiectasia (HHT) Efficacy and Safety of a 0.1% Tacrolimus Nasal Ointment as a Treatment for Epistaxis in Hemorrhagic Hereditary Telangiectasia (HHT) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have

2017 Clinical Trials

134. The Effect of Lithospermum officinale, Silver Sulfadiazine and Alpha Ointments in Healing of Burn Wound Injuries in Rat (PubMed)

and alpha ointment were used after burn injury.It can be concluded that topical application of L. officinale as a non-toxic, inexpensive and easy to produce herbal can lead to a rapid epithelialization and wound healing and these findings can be added to the literature on burn wound healing. (...) The Effect of Lithospermum officinale, Silver Sulfadiazine and Alpha Ointments in Healing of Burn Wound Injuries in Rat Burn is the most devastating condition in emergency medicine leading to chronic disabilities. This study aimed to compare the effect of Lithospermum officinale, silver sulfadiazine and alpha ointments on healing of burn wounds in rat.Ninety-five rats were divided into 5 groups. Group 1 just underwent burn injury, and groups 2-5 received alpha ointment, silver sulfadiazine (SSD

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2017 World journal of plastic surgery

135. Nasal application of petrolatum ointment - A silent cause of exogenous lipoid pneumonia: Successfully treated with prednisolone (PubMed)

patients who become clinically unstable or an abnormal lung shadow or during evaluation of rhinobronchial allergy. It is rarely reported from chronic use of petrolatum ointment extranasally and was diagnosed by transbronchial biopsy in the present case. She was found, retrospectively, to have been using petrolatum ointment, as an extranasal application since more than a year at bedtime. She didn't give history of using any other oil-based nasal topical vasoconstrictor preparations for sinusitis. Our (...) Nasal application of petrolatum ointment - A silent cause of exogenous lipoid pneumonia: Successfully treated with prednisolone We report a case of exogenous lipoid pneumonia from chronic, extranasal use of petrolatum ointment (Vicks VapoRub in this case) for nasal decongestion in a young woman, presenting with cough, dyspnea and fever. Exogenous Lipoid pneumonia is a rare condition, underdiagnosed and is more prevalent in adults. Usually asymptomatic and diagnosed while evaluating predisposed

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2017 Respiratory Medicine Case Reports

136. Sirolimus Ointment for Facial Angiofibromas in Individuals with Tuberous Sclerosis Complex (PubMed)

Sirolimus Ointment for Facial Angiofibromas in Individuals with Tuberous Sclerosis Complex Background. Facial angiofibromas affect most patients with tuberous sclerosis complex. They tend to progress, can cause recurrent bleeding and facial disfigurement, and have significant psychological effects. We reviewed the effectiveness and safety of topical sirolimus ointment 0.1%. We also assessed the effect of treatment on quality of life. Methods. We report our experience in using sirolimus ointment (...) in 14 patients with TSC (9 children and 5 adults). The impact of sirolimus ointment was monitored with digital photography, dermatological review using a validated Facial Angiofibroma Severity Index (FASI), and quality of life assessments using the questionnaires PedsQL for children and SF36 for adults. Results. The FASI scores were improved in 12/14 cases after six months' treatment, and improvement was more likely in children (median FASI scores of improvement after treatment were 3 points

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2017 International scholarly research notices

137. Efficacy and safety of tacrolimus ointment 0.03% treatment in a 1-month-old "red baby": a case report. (PubMed)

Efficacy and safety of tacrolimus ointment 0.03% treatment in a 1-month-old "red baby": a case report. Several trials have indicated that topical tacrolimus is safe and effective for several immunologic-based skin disorders. We report a child <2 months old, who was admitted to our pediatric department because of generalized erythroderma. We started tacrolimus ointment 0.03% therapy by applying the ointment to the skin once daily, on a limited surface of 10 cm(2), changing the skin areas only (...) to the treatment was good. We conclude that 0.03% tacrolimus ointment is efficacious and safe even in an infant <2 months of age.

2017 Allergy and Asthma Proceedings

138. Topical Tacrolimus is equally effective in treating patients with Oral Lichen Planus (OLP) as compared to Topical clobetasol

into 2 groups: twenty patients were assigned the use of clobetasol propionate (0.05%) ointment (topical corticosteroid) twenty patients were assigned the use of tacrolimus (0.1%) ointment (topical immunosuppressant), for eight weeks each. The patients were instructed to apply the ointment twice a day during the treatment period. Both groups were additionally instructed to use chlorhexidine mouthwash three times per day during the 8 week period. All patients were assessed at 2 weeks, 4 weeks and 8 (...) group, and 81.6% in the clobetasol group. VAS scores after 6 weeks of treatment suggested improvement (p #3) Corrocher /2008 n= 32 RCT Key results This study recruited 32 patients with histologically confirmed OLP. Patients were randomly assigned to two treatment groups; sixteen patients received 2ml of tacrolimus 0.1% ointment, and sixteen patients received 2ml of clobetasol propionate 0.05% ointment. Both groups were instructed to apply the topical medication four times daily for 4 weeks. Patients

2013 UTHSCSA Dental School CAT Library

139. Evaluation of the bacterial ocular surface microbiome in clinically normal horses before and after treatment with topical neomycin-polymyxin-bacitracin. (PubMed)

of the ocular surface microbiome in healthy horses, and to identify whether there are microbial community changes over time and following topical antibiotic use. One eye of 12 horses was treated 3 times daily for 1 week with neomycin-polymyxin-bacitracin ophthalmic ointment. Contralateral eyes served as untreated controls. The inferior conjunctival fornix of both eyes was sampled at baseline prior to initiating treatment (day 0), after 1 week of treatment (day 7), and 4 weeks after concluding treatment (day (...) Evaluation of the bacterial ocular surface microbiome in clinically normal horses before and after treatment with topical neomycin-polymyxin-bacitracin. Next generation sequencing (NGS) studies have demonstrated a rich and diverse ocular surface-associated microbiota in people that was previously undetected by traditional culture-based methods. The ocular surface microbiome of horses has yet to be investigated using NGS techniques. This study aimed to determine the bacterial composition

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2019 PLoS ONE

140. Dressings and topical agents for arterial leg ulcers. (PubMed)

Dressings and topical agents for arterial leg ulcers. It is estimated that people in industrialised countries have a 1% chance of suffering from a leg ulcer at some time in their life. The majority of leg ulcers are associated with circulation problems; poor blood return in the veins causes venous ulcers (around 70% of ulcers) and poor blood supply to the legs causes arterial ulcers (around 22% of ulcers). Treatment of arterial leg ulcers is directed towards correcting the poor arterial blood (...) supply, for example by correcting arterial blockages (either surgically or pharmaceutically). If the blood supply has been restored, these arterial ulcers can heal following principles of good wound care. Dressings and topical agents make up a part of good wound care for arterial ulcers but there are many products available and it is unclear what impact these have on ulcer healing. This is an update of a review first published in 2003.To determine whether topical agents and wound dressings affect

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2015 Cochrane

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