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Topical Ointment

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101. The safety and efficacy of topical retapamulin ointment versus placebo ointment in the treatment of secondarily infected traumatic lesions: a randomized, double-blind superiority study. (Abstract)

The safety and efficacy of topical retapamulin ointment versus placebo ointment in the treatment of secondarily infected traumatic lesions: a randomized, double-blind superiority study. To evaluate whether retapamulin 1% is clinically superior to a placebo in the treatment of patients with secondarily infected traumatic lesions.The study was a double-blind, placebo-controlled, parallel-group, phase 3 study.Patients were recruited from 5 countries.The aforementioned patients were all 2 months

2013 Advances in skin & wound care Controlled trial quality: predicted high

102. Topical emollient for preventing infection in preterm infants. Full Text available with Trip Pro

Topical emollient for preventing infection in preterm infants. Breakdown of the developmentally immature epidermal barrier may permit entry for micro-organisms leading to invasive infection in preterm infants. Topical emollients may improve skin integrity and barrier function and thereby prevent invasive infection, a major cause of mortality and morbidity in preterm infants.To assess the effect of topical application of emollients (ointments, creams, or oils) on the incidence of invasive (...) -randomised trials.Randomised or quasi-randomised controlled trials that assessed the effect of prophylactic application of topical emollient (ointments, creams, or oils) on the incidence of invasive infection, mortality, other morbidity, and growth and development in preterm infants.Two review authors assessed trial eligibility and risk of bias and undertook data extraction independently. We analysed the treatment effects in the individual trials and reported the risk ratio and risk difference

2016 Cochrane

103. Topical antibiotics for preventing surgical site infection in wounds healing by primary intention. Full Text available with Trip Pro

surgery conducted in theatre. Nine different topical antibiotics were included. We included two three-arm trials, two four-arm trials and 10 two-arm trials. The control groups comprised; an alternative topical antibiotic (two studies), topical antiseptic (six studies) and no topical antibiotic (10 studies), which comprised inert ointment (five studies) no treatment (four studies) and one study with one arm of each.The risk of bias of the 14 studies varied. Seven studies were at high risk of bias, five (...) contact dermatitis; there was no clear difference in the risk of dermatitis between topical antibiotics and antiseptics, however this comparison was underpowered and a difference cannot be ruled out (RR 0.97, 95% CI 0.52 to 1.82; very low-quality evidence, downgraded twice for risk of bias and once for imprecision). Topical antibiotic versus topical antibioticOne study (99 participants) compared mupirocin ointment with a combination ointment of neomycin/polymyxin B/bacitracin zinc for the outcome

2016 Cochrane

104. Dressings and topical agents for arterial leg ulcers. (Abstract)

Dressings and topical agents for arterial leg ulcers. It is estimated that people in industrialised countries have a 1% chance of suffering from a leg ulcer at some time in their life. The majority of leg ulcers are associated with circulation problems; poor blood return in the veins causes venous ulcers (around 70% of ulcers) and poor blood supply to the legs causes arterial ulcers (around 22% of ulcers). Treatment of arterial leg ulcers is directed towards correcting the poor arterial blood (...) supply, for example by correcting arterial blockages (either surgically or pharmaceutically). If the blood supply has been restored, these arterial ulcers can heal following principles of good wound care. Dressings and topical agents make up a part of good wound care for arterial ulcers but there are many products available and it is unclear what impact these have on ulcer healing. This is an update of a review first published in 2003.To determine whether topical agents and wound dressings affect

2015 Cochrane

105. Topical tacrolimus for atopic dermatitis. Full Text available with Trip Pro

Topical tacrolimus for atopic dermatitis. Atopic dermatitis (AD) (or atopic eczema) is a chronic inflammatory skin condition that affects children and adults and has an important impact on quality of life. Topical corticosteroids (TCS) are the first-line therapy for this condition; however, they can be associated with significant adverse effects when used chronically. Tacrolimus ointment (in its 2 manufactured strengths of 0.1% and 0.03%) might be an alternative treatment. Tacrolimus, together (...) with pimecrolimus, are drugs called topical calcineurin inhibitors (TCIs).To assess the efficacy and safety of topical tacrolimus for moderate and severe atopic dermatitis compared with other active treatments.We searched the following databases up to 3 June 2015: the Cochrane Skin Group Specialised Register, CENTRAL in the Cochrane Library (Issue 5, 2015), MEDLINE (from 1946), EMBASE (from 1974), LILACS (from 1982), and the Global Resource of Eczema Trials (GREAT database). We searched six trials registers

2015 Cochrane

106. Topical Tacrolimus is equally effective in treating patients with Oral Lichen Planus (OLP) as compared to Topical clobetasol

into 2 groups: twenty patients were assigned the use of clobetasol propionate (0.05%) ointment (topical corticosteroid) twenty patients were assigned the use of tacrolimus (0.1%) ointment (topical immunosuppressant), for eight weeks each. The patients were instructed to apply the ointment twice a day during the treatment period. Both groups were additionally instructed to use chlorhexidine mouthwash three times per day during the 8 week period. All patients were assessed at 2 weeks, 4 weeks and 8 (...) group, and 81.6% in the clobetasol group. VAS scores after 6 weeks of treatment suggested improvement (p #3) Corrocher /2008 n= 32 RCT Key results This study recruited 32 patients with histologically confirmed OLP. Patients were randomly assigned to two treatment groups; sixteen patients received 2ml of tacrolimus 0.1% ointment, and sixteen patients received 2ml of clobetasol propionate 0.05% ointment. Both groups were instructed to apply the topical medication four times daily for 4 weeks. Patients

2013 UTHSCSA Dental School CAT Library

107. Efficacy of topical alpha ointment (containing natural henna) compared to topical hydrocortisone (1%) in the healing of radiation-induced dermatitis in patients with breast cancer: a randomized controlled clinical trial. Full Text available with Trip Pro

Efficacy of topical alpha ointment (containing natural henna) compared to topical hydrocortisone (1%) in the healing of radiation-induced dermatitis in patients with breast cancer: a randomized controlled clinical trial. This two-arm, randomized clinical study aimed to compare efficacy between topical Alpha ointment and topical hydrocortisone cream (1%) in the healing of radiation-induced dermatitis in breast cancer patients.The inclusion criteria comprised newly pathologically proven, locally (...) advanced breast cancer (treated with modified radical mastectomy followed by sequential adjuvant treatments, including chest wall radiotherapy [45-50.4 Gy]) and grade 2 and/or 3 chest wall dermatitis. The exclusion criteria were comprised of any underlying disease or medications interfering with the wound healing process, previous history of chest wall radiotherapy, and concurrent use of chemotherapy. Sixty eligible patients were randomly assigned to use either topical Alpha ointment (study arm, n=30

2013 Iranian journal of medical sciences Controlled trial quality: uncertain

108. Chronic anal fissure: 2% topical diltiazem hydrochloride

headache, perianal itching and perianal dermatitis have been reported with the use of 2% topical diltiazem hydrochloride. The NHS price for 2% diltiazem cream is £73.83 per 30 g tube and the NHS price for 2% diltiazem ointment is £163.07 per 30 g tube. The licensed topical glyceryl trinitrate product, Rectogesic 4 mg/g rectal ointment, costs £34.80 per 30 g tube (costs exclude VAT and are taken from the Drug T ariff, February 2013). An application for a marketing authorisation (product licence) for 4 (...) and the suitability of using diltiazem outside its authorised indications. An alternative topical treatment, 0.4% glyceryl trinitrate, is licensed in the UK for the relief of pain associated with chronic anal fissure in adults (Rectogesic 4 mg/g rectal ointment, ProStrakan). It is not recommended for use in children and young people under 18 years because of a lack of data on safety and efficacy [1] . Headache is very commonly reported by people using 0.4% topical glyceryl trinitrate. Although this can be treated

2013 National Institute for Health and Clinical Excellence - Advice

109. Green tea leaf extract (Veregen) - an aggressive topical treatment for anogenital warts

In patients with troublesome anogenital wart s, who are able and willing to apply a topical treatment themselves, ointment containing green tea leaf extract has no demonstrated advantages in terms of efficacy, adverse effects or convenience over topical treatments containing imiquimod or podophyllotoxin. In practice , it is better to choose the better established drugs imiquimod or podophyllotoxin. Full text available for free download. ©Prescrire 1 April 2015 Download the full review See also (...) Green tea leaf extract (Veregen) - an aggressive topical treatment for anogenital warts Prescrire IN ENGLISH - Spotlight ''In the April issue of Prescrire International: Green tea leaf extract (Veregen°) - an aggressive topical treatment for anogenital warts'', 1 April 2015 {1} {1} {1} | | > > > In the April issue of Prescrire International: Green tea leaf extract (Veregen°) - an aggressive topical treatment for anogenital warts Spotlight Every month, the subjects in Prescrire’s Spotlight. 100

2015 Prescrire

110. Topical Nitroglycerin for Peripheral Circulation and Wound Healing in the Elderly

with peripheral vascular disease Intervention Topical nitroglycerin (e.g., ointment, paste, patches) Comparator ? Placebo or no treatment ? No comparator Outcomes Q1: Clinical effectiveness: ? Benefits (e.g., increased circulation, wound healing) ? Harms (e.g., hypotension, falls, localized skin sensitivity) Q2: Evidence-based guidelines Study Designs Health technology assessments, systematic reviews, meta-analyses, randomized controlled trials, non-randomized studies, evidence-based guidelines RESULTS Rapid (...) action on thrombophlebitis induced by sclerosis of leg varicose veins. Angiology. 1994 May;45(5):347-51. PubMed: PM8172381 6. Fischer M, Reinhold B, Falck H, Torok M, Alexander K. Topical nitroglycerin ointment in Raynaud's phenomenon. Z Kardiol. 1985 May;74(5):298-302. PubMed: PM3925656 7. Franks AG, Jr. Topical glyceryl trinitrate as adjunctive treatment in Raynaud's disease. Lancet. 1982 Jan 9;1(8263):76-7. PubMed: PM6119495 Non-Randomized Studies Unclear Population Age 8. Anderson ME, Moore TL

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

111. Ping On, An Herbal Ointment, May Be More Effective Than Placebo For Reducing Pain And Severity Of TMD Pain In Adult Patients

Ping On, An Herbal Ointment, May Be More Effective Than Placebo For Reducing Pain And Severity Of TMD Pain In Adult Patients UTCAT2273, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Ping On, An Herbal Ointment, May Be More Effective Than Placebo For Reducing Pain And Severity Of TMD Pain In Adult Patients Clinical Question In an adult patient with TMD, are herbal remedies more effective than placebo in reducing (...) the severity or duration of pain? Clinical Bottom Line Ping On, an herbal ointment, may be more effective than placebo for reducing pain and severity of TMD pain in adult patients. Other herbal treatment would need additional investigation. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Li/2009 Patients with TMJ and/ or masticatory pain Double Blind Randomized Control Trial Key results Ping On ointment

2012 UTHSCSA Dental School CAT Library

112. Tacrolimus ointment (Protopic): possible risk of malignancies including lymphomas and skin cancers

: Therapeutic area: Contents Article date: June 2012 Tacrolimus ointment (Protopic) is used to treat moderate to severe atopic dermatitis flares, and to maintain flare-free intervals, in adults and adolescents age 16 years and older, who do not respond to, or are intolerant of, conventional therapies such as topical corticosteroids. Protopic is available in 2 strengths containing tacrolimus 0.03% and 0.1%, respectively. The lower strength ointment can be used to treat moderate to severe atopic dermatitis (...) of malignancies, including lymphomas and skin cancers have also been reported in patients using topically applied tacrolimus since it was licensed in 1999. In addition, findings from epidemiological studies have suggested a possible increased risk of cutaneous T-cell lymphoma in patients treated with topical calcineurin inhibitors, including tacrolimus ointment . Healthcare professionals must remember that Protopic should not be prescribed to patients younger than 2 years, and that the use of Protopic

2012 MHRA Drug Safety Update

113. Evaluation of the bacterial ocular surface microbiome in clinically normal horses before and after treatment with topical neomycin-polymyxin-bacitracin. Full Text available with Trip Pro

of the ocular surface microbiome in healthy horses, and to identify whether there are microbial community changes over time and following topical antibiotic use. One eye of 12 horses was treated 3 times daily for 1 week with neomycin-polymyxin-bacitracin ophthalmic ointment. Contralateral eyes served as untreated controls. The inferior conjunctival fornix of both eyes was sampled at baseline prior to initiating treatment (day 0), after 1 week of treatment (day 7), and 4 weeks after concluding treatment (day (...) Evaluation of the bacterial ocular surface microbiome in clinically normal horses before and after treatment with topical neomycin-polymyxin-bacitracin. Next generation sequencing (NGS) studies have demonstrated a rich and diverse ocular surface-associated microbiota in people that was previously undetected by traditional culture-based methods. The ocular surface microbiome of horses has yet to be investigated using NGS techniques. This study aimed to determine the bacterial composition

2019 PLoS ONE

114. Comparison of Collagenase Santyl Ointment With Antibiotic Ointment in the Outpatient Care of Minor Partial Thickness Burns

Pharmacopeia (USP). Sham Comparator: Bacitracin Applied topically (2 mm thickness) once daily Drug: Bacitracin One gram is equal to 500 bacitracin units; one unit of bacitracin is equivalent to 0.026 milligrams. Other Name: Bacitracin Zinc Ointment Outcome Measures Go to Primary Outcome Measures : Proportion Healed [ Time Frame: 21 Days After Treatment ] Outcome will be reported as percent of wound epithelialization. Secondary Outcome Measures : Scar Appearance using the Vancouver Scar Scale [ Time Frame (...) Comparison of Collagenase Santyl Ointment With Antibiotic Ointment in the Outpatient Care of Minor Partial Thickness Burns Comparison of Collagenase Santyl Ointment With Antibiotic Ointment in the Outpatient Care of Minor Partial Thickness Burns - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2016 Clinical Trials

115. Therapeutic Effect of Tzu-Yun Ointment on Patients with Atopic Dermatitis: A Preliminary, Randomized, Controlled, Open-Label Study. (Abstract)

Therapeutic Effect of Tzu-Yun Ointment on Patients with Atopic Dermatitis: A Preliminary, Randomized, Controlled, Open-Label Study. Atopic dermatitis comprises a group of chronic, relapsing inflammatory conditions. Topical steroids (TS) can ameliorate atopic dermatitis but induce skin atrophy and secondary infection. Tzu-Yun ointment (TYO) was used widely for skin ulcers and pus discharges. This study sought to determine whether TYO can replace TS therapy for atopic dermatitis.This preliminary

2016 Journal of alternative and complementary medicine (New York, N.Y.) Controlled trial quality: uncertain

116. Efficacy of Twice Daily Application of LEO 124249 Ointment 30 mg/g for 12 Weeks on Eyebrow Alopecia Areata.

topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: LEO 124249 ointment 30 mg/g Ointment to be applied on the eyebrow twice daily. Drug: LEO 124249 Ointment containing LEO 124249 Placebo Comparator: LEO 124249 ointment vehicle Ointment to be applied on the eyebrow twice daily. Other: Ointment vehicle Ointment without active ingredients Outcome Measures Go to Primary Outcome Measures : Change from baseline to week 12 of investigator evaluated overall area score (ASoverall L+R (...) Efficacy of Twice Daily Application of LEO 124249 Ointment 30 mg/g for 12 Weeks on Eyebrow Alopecia Areata. Efficacy of Twice Daily Application of LEO 124249 Ointment 30 mg/g for 12 Weeks on Eyebrow Alopecia Areata. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2017 Clinical Trials

117. Long-term safety of crisaborole ointment 2% in children and adults with mild to moderate atopic dermatitis. Full Text available with Trip Pro

Long-term safety of crisaborole ointment 2% in children and adults with mild to moderate atopic dermatitis. Long-term topical treatment is often required for atopic dermatitis (AD), a chronic inflammatory skin disease.To assess the long-term safety results from a multicenter, open-label, 48-week safety study (AD-303) of patients (N = 517) ≥2 years of age with mild to moderate AD who continued crisaborole treatment, a topical phosphodiesterase-4 inhibitor, after completing a 28-day phase 3 (...) of TEAEs were consistent. The most frequently reported treatment-related AEs (overall, 10.2%) were dermatitis atopic (3.1%), application-site pain (2.3%), and application-site infection (1.2%). Nine patients (1.7%) discontinued the long-term study because of TEAEs.Long-term efficacy was not analyzed.Crisaborole ointment had a low frequency of treatment-related AEs over 48 weeks of treatment of patients with AD.Copyright © 2017 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights

2017 Journal of American Academy of Dermatology

118. Comparison of indirubin concentrations in indigo naturalis ointment for psoriasis treatment: a randomized, double-blind, dosage-controlled trial. (Abstract)

Comparison of indirubin concentrations in indigo naturalis ointment for psoriasis treatment: a randomized, double-blind, dosage-controlled trial. Indigo naturalis and its refined formulation, Lindioil, are effective in treating psoriatic symptoms topically. Indirubin is the active ingredient in indigo naturalis.To determine the efficacy and safety of different concentrations of indirubin in Lindioil ointment for treating psoriasis.In this randomized, double-blind trial, adult patients (...) ) was the 200 μg g-1 group. No severe treatment-related adverse events were reported during the 20-week evaluation.An amount of 200 μg g-1 of indirubin in Lindioil ointment is the most effective concentration studied so far for treating psoriasis topically, and is safe.© 2017 British Association of Dermatologists.

2017 British Journal of Dermatology Controlled trial quality: predicted high

119. Crisaborole Ointment 2%: A Review in Mild to Moderate Atopic Dermatitis. (Abstract)

Crisaborole Ointment 2%: A Review in Mild to Moderate Atopic Dermatitis. Crisaborole ointment 2% (Eucrisa™) is a novel, anti-inflammatory inhibitor of phosphodiesterase 4 (PDE4) that is available in the USA for the topical treatment of mild to moderate atopic dermatitis in patients aged ≥ 2 years. In two short-term (28 days), identically designed, multicentre, phase III studies in this patient population, topical therapy with crisaborole ointment 2% reduced disease severity and pruritus (...) of mild to moderate severity and considered unrelated to the study medication. Moreover, the incidence of application-site pain following short- and longer-term topical therapy with crisaborole ointment 2% was low. In conclusion, crisaborole ointment 2% is an effective and generally well tolerated new topical option for the management of mild to moderate atopic dermatitis in patients aged ≥ 2 years, with the potential to effectively treat this patient population over the longer term without the safety

2017 American journal of clinical dermatology

120. Low incidence of hypercalcemia following combined calcipotriol hydrate/betamethasone dipropionate ointment treatment in Japanese patients with severe psoriasis vulgaris. (Abstract)

Low incidence of hypercalcemia following combined calcipotriol hydrate/betamethasone dipropionate ointment treatment in Japanese patients with severe psoriasis vulgaris. Topical active vitamin D3 application alone or in combination with topical steroid application is widely used to treat psoriasis. In Japan, combined calcipotriol hydrate/betamethasone dipropionate ointment has been used for patients with psoriasis vulgaris since September 2014. Current evidence regarding the incidence (...) Ca concentration changed only marginally, from 9.04 ± 0.34 mg/dL before treatment to 9.08 ± 0.39 mg/dL after 8 weeks of treatment. None of the patients had an elevated serum Ca concentration throughout the study. No cases of hypercalcemia were reported as an adverse event. No correlation was detected between the amount of the combined calcipotriol hydrate/betamethasone dipropionate ointment applied and changes in the serum Ca concentration.The incidence of hypercalcemia due to topical application

2017 Journal of Dermatological Treatment

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