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Topical Ointment

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61. COMPARISON OF PAIN CONTROL DURING TRUS GUIDED BIOPSIES BETWEEN BASAL PERI-PROSTATIC LOCAL INFILTRATION ANESTHESIA VERSUS COMBINED TOPICAL ANAL LIGNOCAINE OINTMENT AND LOCAL INFILTRATION ANESTHESIA. (Abstract)

COMPARISON OF PAIN CONTROL DURING TRUS GUIDED BIOPSIES BETWEEN BASAL PERI-PROSTATIC LOCAL INFILTRATION ANESTHESIA VERSUS COMBINED TOPICAL ANAL LIGNOCAINE OINTMENT AND LOCAL INFILTRATION ANESTHESIA. Control of pain associated with TRUS guided biopsies was the target of many researches that tried peri-prostatic local infiltration anesthesia (PLIA) either basal, apical, combined or topical anesthesia (TA). Thus, the efficacy of (PLIA) alone versus (PLIA) combined with (TA) in pain control during (...) TRUS guided biopsies was compared. A total of 163 patients with a mean age±2stdev (61±1.4 years) and a mean PSA ± 2stdev (8.5±1. lng/ml) 84 patients (Gl) were randomized to receive either PLIA alone (Gl) or 79 patients (G2) combined TA (using lignocaine 5% ointment of the anal ring, anal canal, and anterior rectal wall and basal PLIA via injecting 5 ml 2% xylocaine in both sides of the base), with cross-matched mean ages. Patients were asked to scale pain from 0-10 during probe insertion (P1

2015 Journal of the Egyptian Society of Parasitology Controlled trial quality: uncertain

62. An Observational Study Investigating the Treatment Satisfaction of Atopic Dermatitis Patients Who Have Switched to Ointment (W/O Emulsion) Formulation of Very Strong Class Topical Corticosteroids

An Observational Study Investigating the Treatment Satisfaction of Atopic Dermatitis Patients Who Have Switched to Ointment (W/O Emulsion) Formulation of Very Strong Class Topical Corticosteroids An Observational Study Investigating the Treatment Satisfaction of Atopic Dermatitis Patients Who Have Switched to Ointment (W/O Emulsion) Formulation of Very Strong Class Topical Corticosteroids - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer (...) to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. An Observational Study Investigating the Treatment Satisfaction of Atopic Dermatitis Patients Who Have Switched to Ointment (W/O Emulsion) Formulation of Very Strong Class Topical Corticosteroids (Ointment TS-AD) The safety and scientific validity of this study

2015 Clinical Trials

63. Study of Safety and Efficacy of Topical GSK2981278 Ointment in Plaque Psoriasis

Study of Safety and Efficacy of Topical GSK2981278 Ointment in Plaque Psoriasis Study of Safety and Efficacy of Topical GSK2981278 Ointment in Plaque Psoriasis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Study of Safety and Efficacy of Topical GSK2981278 Ointment in Plaque Psoriasis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02548052 Recruitment Status : Completed First Posted : September 14, 2015 Last Update Posted : May 15, 2017 Sponsor: GlaxoSmithKline Information provided by (Responsible

2015 Clinical Trials

64. Effect of topical ophthalmic dorzolamide(2%)-timolol(0.5%) solution and ointment on intraocular pressure in normal horses. (Abstract)

Effect of topical ophthalmic dorzolamide(2%)-timolol(0.5%) solution and ointment on intraocular pressure in normal horses. To compare the effect of commercially available solution and compounded ointment formulations of dorzolamide(2%)-timolol(0.5%) on intraocular pressure (IOP) of normal horses.Eighteen clinically normal horses.A randomized, masked prospective design was used with horses divided into two equal groups. One eye of each horse was selected for topical ophthalmic treatment (...) with either 0.2 mL of dorzolamide(2%)-timolol(0.5%) solution or 0.2 g of dorzolamide(2%)-timolol(0.5%) ointment every 12 h for 5 days. The contralateral eye of horses in both groups was untreated. Rebound tonometry was performed every 6 h starting 2 days prior to and ending 2 days after the treatment period.The mean IOP reduction in eyes treated with the solution or ointment formulations was 13%. Untreated eyes in both groups experienced a lesser but still statistically significant reduction in IOP

2015 Veterinary ophthalmology Controlled trial quality: uncertain

65. Calcipotriene 0.005%--betamethasone dipropionate 0.064% ointment versus topical suspension in the treatment of plaque psoriasis: a randomized pilot study of patient preference. (Abstract)

Calcipotriene 0.005%--betamethasone dipropionate 0.064% ointment versus topical suspension in the treatment of plaque psoriasis: a randomized pilot study of patient preference. Vehicle formulation plays a major role in patient adherence to topical psoriasis treatments. The objective of this study was to conduct a preliminary assessment of patient preference for ointment versus topical suspension formulations of calcipotriene 0.005%-betamethasone dipropionate 0.064% for treatment of plaque (...) psoriasis. In our small cohort of 20 participants with mild to moderate plaque psoriasis, the topical suspension formulation was preferred over the ointment, though the difference was not statistically significant (P=.32). Overall, the topical suspension was rated as moderately appealing, while the ointment was rated as slightly appealing (P=.06). Subgroup analyses were limited due to the small sample size. The results of this study may provide clinicians with an alternative topical treatment of plaque

2015 Cutis Controlled trial quality: uncertain

66. Topical Antibiotic Ointment Versus Silver-containing Foam Dressing for Second-degree Burns in Swine. (Abstract)

Topical Antibiotic Ointment Versus Silver-containing Foam Dressing for Second-degree Burns in Swine. Second-degree burns are very common but their management is controversial. These burns may be treated with either topical antimicrobial agents or advanced occlusive dressings; however, there is no established treatment comparator for preclinical studies. This study was designed to determine which of two commonly used comparator therapies (a silver-containing advanced dressing or a topical (...) antibiotic ointment) resulted in faster reepithelialization and less scarring. The hypothesis was that second-degree burns treated with a topical antimicrobial ointment would heal faster and with less scarring than those treated with a silver-containing occlusive foam dressing in a porcine model.Deep partial-thickness burns were created on the flanks of three anesthetized female domestic pigs (20 to 25 kg) using a 150-g aluminum bar preheated in 80°C water bath and applied to the skin for 20 seconds

2015 Academic Emergency Medicine

67. Topical combination therapy with vitamin D3 and corticosteroid ointment for palmoplantar pustulosis: A prospective, randomized, left-right comparison study. (Abstract)

Topical combination therapy with vitamin D3 and corticosteroid ointment for palmoplantar pustulosis: A prospective, randomized, left-right comparison study. Vitamin D3 ointment and corticosteroid ointment are both used for the treatment of palmoplantar pustulosis (PPP). However, to date there is no systematic study of the efficacy of combination therapy for the treatment of PPP.We compared the efficacy of a topical combination therapy with vitamin D3 and a topical corticosteroid (...) with that of topical corticosteroid alone in the treatment of PPP.We evaluated left-right comparison study of the efficacy of a combination therapy consisting of maxacalcitol ointment and betamethasone butyrate propionate ointment (BBP), and monotherapy with BBP alone in 27 patients with PPP for 8 weeks.The improvement in the symptom (erythema, pustules/vesicles, hyperkeratosis/scales) scores was high for the combination therapy. In particular, the improvement rate for pustules/vesicles at week 8 after

2015 The Journal of dermatological treatment Controlled trial quality: uncertain

68. A Study to Evaluate the Safety and Efficacy of Topically Applied TV 45070 Ointment in Patients With Postherpetic Neuralgia (PHN)

A Study to Evaluate the Safety and Efficacy of Topically Applied TV 45070 Ointment in Patients With Postherpetic Neuralgia (PHN) A Study to Evaluate the Safety and Efficacy of Topically Applied TV 45070 Ointment in Patients With Postherpetic Neuralgia (PHN) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have (...) reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study to Evaluate the Safety and Efficacy of Topically Applied TV 45070 Ointment in Patients With Postherpetic Neuralgia (PHN) ((PHN)) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02365636

2015 Clinical Trials

69. Antibacterial Ointments Versus Petrolatum-Based Ointments in Clean Wounds for Wound Healing

varied advice for wound care. Topical antibacterial ointments are commonly used to facilitate wound healing in patients with these types of wounds. Topical antibacterial ointments have been shown to cause allergic contact dermatitis, may cause an increase in antibiotic resistance, and may be equally efficacious when compared to petrolatum-based ointments for healing clean wounds. Method: An exhaustive search of available medical literature was performed using Medline, CINHAL, and Cochrane databases (...) Antibacterial Ointments Versus Petrolatum-Based Ointments in Clean Wounds for Wound Healing "Antibacterial Ointments Versus Petrolatum-Based Ointments in Clean Wo" by Kate Muirhead < > > > > > Title Author Date of Graduation Summer 8-11-2012 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies First Advisor Annjanette Sommers MS, PA-C Rights . Abstract Background: Clean wounds are a frequent occurrence in the medical field and medical providers provide

2012 Pacific University EBM Capstone Project

70. Antimicrobial Ointments for Patients Undergoing Hemodialysis

, and they are not without risk. For example, the widespread prophylactic use of topical antibiotics, particularly mupirocin, may lead to an increased prevalence of drug-resistant micro-organisms. 3,4,6,7 These ongoing concerns with regard to mupirocin microbial drug resistance have raised the question whether an antiseptic ointment, alternative antimicrobial ointments, or antiseptic-impregnated dressing products may be preferable alternatives. This Rapid Response report aims to provide information on the clinical (...) Relevant Interventions, N studies Outcomes McCann 2010 1 Patients with end-stage kidney disease requiring hemodialysis and using a central venous catheter as vascular access. • Topical antimicrobial vs no antimicrobial N=5 studies (379 patients) • Topical mupirocin ointment vs no ointment N=3 studies (217 patients) • Topical povidone-iodine ointment vs no ointment N=1 study (129 patients) • Topical Polysporin Triple ointment vs placebo N=1 study (162 patients) Primary outcomes • Infectious

2013 Canadian Agency for Drugs and Technologies in Health - Rapid Review

71. Infantile haemangioma: topical timolol

group. The largest prospective study of topical timolol for the treatment of infantile haemangiomas (Yu et al 2013) included 124 infants with cutaneous superficial haemangiomas. Of these, 101 received topical 0.5% timolol drops applied 3 times a day, with erythromycin ointment applied around the lesion to stop the drops from leaking. The other 23 infants underwent observation only. Response was evaluated from photographs with changes in colour, size and texture recorded. At 4 months, timolol (...) ) were included. Infants with bronchial asthma, sinus bradycardia and second- or third-degree atrioventricular block were not excluded from the study. Of the 124 infants 101 received topical 0.5% timolol drops applied to the surface of the haemangioma 3 times a day, with erythromycin ointment applied around the lesion to stop the drops from leaking. The other 23 infants underwent observation only. The haemangiomas were photographed once a week and changes in colour, size and texture recorded, along

2015 National Institute for Health and Clinical Excellence - Advice

72. Re-Use of Open tubes of Antibiotic Creams and Ointments: Clinical Evidence, Safety, and Guidelines

Re-Use of Open tubes of Antibiotic Creams and Ointments: Clinical Evidence, Safety, and Guidelines Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. Rapid (...) Creams and Ointments: Clinical Evidence, Safety, and Guidelines DATE: 03 July 2012 RESEARCH QUESTIONS 1. What is the clinical evidence regarding the safety of the use of open tubes of antibiotic creams and ointments for wound care for patients in hospitals or long term care? 2. What are the evidence-based guidelines regarding the use of open tubes of antibiotic creams and ointments for wound care for patients in hospitals or long term care? KEY MESSAGE No literature was identified regarding

2012 Canadian Agency for Drugs and Technologies in Health - Rapid Review

73. Superficial Bacterial Skin Infections - Guidelines for Prescribing Topical Antibiotics for impetigo and folliculitis

not been studied during breastfeeding Fucidin-H® has no evidence for improved outcomes vs. fusidic acid monotherapy Folliculitis and Furuncles Folliculitis should be treated with non-pharmacologic measures for 1 week. If not resolved, topical antibiotic treatment may be indicated Mupirocin 2% Cream or Ointment inhibits bacterial protein synthesis of Gram-positive bacteria. Each gram of ointment contains 20mg mupirocin in a water-soluble ointment base containing polyethylene glycol. The cream is an oil (...) Superficial Bacterial Skin Infections - Guidelines for Prescribing Topical Antibiotics for impetigo and folliculitis Superficial Bacterial Skin Infections - Guidelines for Prescribing Topical Antibiotics for impetigo and folliculitis - medSask Home - College of Pharmacy and Nutrition - University of Saskatchewan Toggle Menu Search the U of S Search Superficial Bacterial Skin Infections - Guidelines for Prescribing Topical Antibiotics for impetigo and folliculitis The skin has an effective

2017 medSask

74. Diaper Dermatitis, Irritant and Candidal - Guidelines for Prescribing Topical Antifungals and Hydrocortisone

Diaper Dermatitis, Irritant and Candidal - Guidelines for Prescribing Topical Antifungals and Hydrocortisone Diaper Dermatitis, Irritant and Candidal - Guidelines for Prescribing Topical Antifungals and Hydrocortisone - medSask Home - College of Pharmacy and Nutrition - University of Saskatchewan Toggle Menu Search the U of S Search Diaper Dermatitis, Irritant and Candidal - Guidelines for Prescribing Topical Antifungals and Hydrocortisone A rash occurring under the covered area of a diaper (...) to confirm diagnosis and symptoms / history suggestive of other conditions (See Differential Diagnosis ) which require further investigation and supervised therapy. Mild diaper dermatitis usually responds well to non-pharmaracological measures and regular use of topical barrier products. Topical hydrocortisone and antifungal products should be reserved for symptoms which are causing infant discomfort. Non-pharmacological measures Frequent diaper changes. Change the diaper up to every 2 hours, or any time

2017 medSask

75. Topical steroids better than vitamin D for treating scalp psoriasis

, but the difference was not considered clinically important. The combination ointment costs almost £20 for 30g compared to a 30g tube of typical steroid ointment which costs about £4. Scalp psoriasis is a common condition that can be itchy and embarrassing for many. A variety of topical lotions, solutions or gels are available to treat the condition, so this review of published research aimed to help doctors and patients find out which was the most effective and safest option. This systematic review found 59 (...) . In extreme cases it can cause hair loss, although this is usually only temporary. Topical treatments (creams and ointments for the skin) such as corticosteroids (steroids) and vitamin D are usually the first treatments tried, but applying them to the scalp is difficult because of hair on the head. It is also not clear which works best. This study aimed to help doctors and patients decide which of the wide variety of topical treatments available work best, and the type and frequency of any side effects

2019 NIHR Dissemination Centre

76. Systemic Tofacitinib Concentrations in Adult Patients With Atopic Dermatitis Treated With 2% Tofacitinib Ointment and Application to Pediatric Study Planning. Full Text available with Trip Pro

-group study (NCT02001181) in adult patients with mild to moderate atopic dermatitis and 2% to 20% body surface area (BSA) involvement. Tofacitinib ointment demonstrated significantly greater efficacy versus vehicle for all efficacy end points and had an acceptable safety profile. Predose and postdose pharmacokinetic samples were collected in week 2 and week 4. The objective of this analysis was to assess if predicted mean tofacitinib concentrations with topical application at higher treated BSA (...) Systemic Tofacitinib Concentrations in Adult Patients With Atopic Dermatitis Treated With 2% Tofacitinib Ointment and Application to Pediatric Study Planning. Atopic dermatitis is a chronic eczematous, pruritic, inflammatory skin condition affecting children and adults. Tofacitinib is a Janus kinase inhibitor. The efficacy, safety, and pharmacokinetics of 2% tofacitinib ointment twice daily have been evaluated in a 4-week phase 2a multisite randomized, double-blind, vehicle-controlled, parallel

2018 Journal of clinical pharmacology Controlled trial quality: uncertain

77. Randomized, Prospective, Open-label Phase III Trial Comparing Mebo Ointment With Biafine Cream for the Management of Acute Dermatitis During Radiotherapy for Breast Cancer. (Abstract)

dermatitis in breast cancer patients receiving adjuvant radiation therapy.This is a prospective open-label randomized phase III study developed to assess the efficacy of 2 topical agents used for management of acute radiation dermatitis. Female breast cancer patients who needed a course of radiation therapy in our institution were enrolled and randomized into 2 groups 1 with Mebo ointment and 1 with Biafine cream. Both medications were applied twice per day during the whole period of treatment and skin (...) Randomized, Prospective, Open-label Phase III Trial Comparing Mebo Ointment With Biafine Cream for the Management of Acute Dermatitis During Radiotherapy for Breast Cancer. Acute radiation dermatitis is a common side-effect of radiotherapy in breast cancer and has a profound impact on patients' quality of life, due to pain and discomfort. The aim of this study is to compare the effect of β-sitosterol (Mebo) ointment to trolamine (Biafine) cream for the prevention and treatment of radiation

2018 American journal of clinical oncology Controlled trial quality: uncertain

78. A double-blind, placebo-controlled, randomized study to evaluate the weight gain drug, mirtazapine transdermal ointment, in cats with unintended weight loss. Full Text available with Trip Pro

change in body weight was +3.9% (standard deviation ±5.4%) in the mirtazapine group and +0.4% (±3.3%) in the placebo group (p < 0.0001). The most common adverse event was mild erythema at the application site in 17.4% of placebo and 10.4% of mirtazapine-treated cats. Application of mirtazapine transdermal ointment was well tolerated both topically and systemically and resulted in significant weight gain in cats experiencing unintended weight loss associated with various underlying diseases.© 2018 (...) A double-blind, placebo-controlled, randomized study to evaluate the weight gain drug, mirtazapine transdermal ointment, in cats with unintended weight loss. Mirtazapine is classified as a weight gain drug in cats, and the purpose of this study was to evaluate its efficacy in cats experiencing unintended weight loss. This was a multi-center, double-blind, placebo-controlled, randomized clinical study in client-owned cats ≥1 year of age, weighing ≥2 kg, with a documented loss (≥5%) in body

2018 Journal of veterinary pharmacology and therapeutics

79. Impact of Hypericum Perforatum Ointment on Perineal Pain Intensity Following Episiotomy: a Randomized Placebo-Controlled Trial. Full Text available with Trip Pro

(mean difference=2.21; P<0.001) following the intervention. Conclusion: Using Hypericum Perforatum ointment as a noninvasive, simple and effective topical formulation, can significantly reduce pain intensity of episiotomy site. (...) Impact of Hypericum Perforatum Ointment on Perineal Pain Intensity Following Episiotomy: a Randomized Placebo-Controlled Trial. Introduction: The present study was conducted to evaluate the effects of Hypericum Perforatum ointment on perineal pain intensity following episiotomy among primiparous women. Methods This triple-blind clinical trial was performed on 98 eligible primiparous women referring to selected educational hospital of Tehran University of Medical Sciences for normal vaginal

2018 Journal of caring sciences Controlled trial quality: predicted high

80. Tacrolimus Ointment for Refractory Posterior Blepharitis. (Abstract)

scoring for pruritus and dry eye sensation in the tacrolimus group.This study suggests that topical administration of 0.03% tacrolimus ointment can improve some symptoms and some ocular surface status in patients with refractory posterior blepharitis. (...) Tacrolimus Ointment for Refractory Posterior Blepharitis. This prospective, randomized, double-blind interventional case series was designed to evaluate the short-term efficacy of 0.03% tacrolimus ointment as a new therapeutic approach for refractory cases of posterior blepharitis.Forty eyes (20 patients) with posterior blepharitis refractory to previous treatment were randomized. Eighteen eyes (9 patients) were treated with 0.03% tacrolimus ointment and 20 eyes (10 patients) with placebo

2018 Current eye research Controlled trial quality: uncertain

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