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Topical Ointment

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41. Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients (PubMed)

day, after the delivery of radiation. Skin reaction was recorded and compared between the two halves of the breast. Vitamin D was well tolerated by patients with no local or systemic allergic reactions. Radiation dermatitis was not significantly different between both treatment arms. Topical vitamin D ointment is not superior to Aqua cream for prevention of radiation-induced dermatitis in women treated with adjuvant radiation for breast cancer. (...) Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients Radiation dermatitis occurs frequently during adjuvant radiation therapy for breast cancer. Prevention of radiation dermatitis by applying various creams and ointments has a limited success, and Aqua cream which has urea as one of its active ingredients is used in many institutions as a preventive treatment. The primary goal of this study is to assess the effect of vitamin D (calcipotriol) ointment in prevention

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2017 NPJ breast cancer

42. Topical antimicrobial agents for treating foot ulcers in people with diabetes. (PubMed)

also searched clinical trials registries for ongoing and unpublished studies, and checked reference lists to identify additional studies. We used no restrictions with respect to language, date of publication, or study setting.We included randomised controlled trials conducted in any setting (inpatient or outpatient) that evaluated topical treatment with any type of solid or liquid (e.g., cream, gel, ointment) antimicrobial agent, including antiseptics, antibiotics, and antimicrobial dressings (...) Topical antimicrobial agents for treating foot ulcers in people with diabetes. People with diabetes are at high risk for developing foot ulcers, which often become infected. These wounds, especially when infected, cause substantial morbidity. Wound treatments should aim to alleviate symptoms, promote healing, and avoid adverse outcomes, especially lower extremity amputation. Topical antimicrobial therapy has been used on diabetic foot ulcers, either as a treatment for clinically infected wounds

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2017 Cochrane

43. Dressings and topical agents for treating pressure ulcers. (PubMed)

Dressings and topical agents for treating pressure ulcers. Pressure ulcers, also known as bedsores, decubitus ulcers and pressure injuries, are localised areas of injury to the skin or the underlying tissue, or both. Dressings are widely used to treat pressure ulcers and promote healing, and there are many options to choose from including alginate, hydrocolloid and protease-modulating dressings. Topical agents have also been used as alternatives to dressings in order to promote healing.A clear (...) and current overview of all the evidence is required to facilitate decision-making regarding the use of dressings or topical agents for the treatment of pressure ulcers. Such a review would ideally help people with pressure ulcers and health professionals assess the best treatment options. This review is a network meta-analysis (NMA) which assesses the probability of complete ulcer healing associated with alternative dressings and topical agents.To assess the effects of dressings and topical agents

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2017 Cochrane

44. Topical phenytoin for treating pressure ulcers. (PubMed)

including dressings, ointments and creams such as bacitracin, silver sulphadiazine, neomycin, and phenytoin. Phenytoin is a drug more commonly used in the treatment of epilepsy, but may play an important role in accelerating ulcer healing.To assess the effects of topical phenytoin on the rate of healing of pressure ulcers of any grade, in any care setting.In September 2016, we searched the following electronic databases to identify relevant randomized clinical trials: the Cochrane Wounds Specialised (...) : hydrocolloid dressings, triple antibiotic ointment and simple dressings. In the three RCTs, 79% of participants had grade II ulcers, and 21% of participants had grade I ulcers; no participants had grade III or IV ulcers. Two RCTs had a high risk of bias overall and the other RCT was at unclear risk of bias due to poor reporting. Two RCTs had three intervention arms and the other had two intervention arms.Two studies compared topical phenytoin with hydrocolloid dressing (84 participants analysed

2017 Cochrane

45. Comparison of Collagenase Santyl Ointment With Antibiotic Ointment in the Outpatient Care of Minor Partial Thickness Burns

Pharmacopeia (USP). Sham Comparator: Bacitracin Applied topically (2 mm thickness) once daily Drug: Bacitracin One gram is equal to 500 bacitracin units; one unit of bacitracin is equivalent to 0.026 milligrams. Other Name: Bacitracin Zinc Ointment Outcome Measures Go to Primary Outcome Measures : Proportion Healed [ Time Frame: 21 Days After Treatment ] Outcome will be reported as percent of wound epithelialization. Secondary Outcome Measures : Scar Appearance using the Vancouver Scar Scale [ Time Frame (...) Comparison of Collagenase Santyl Ointment With Antibiotic Ointment in the Outpatient Care of Minor Partial Thickness Burns Comparison of Collagenase Santyl Ointment With Antibiotic Ointment in the Outpatient Care of Minor Partial Thickness Burns - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2016 Clinical Trials

46. The effects of recombinant human epidermal growth factor containing ointment on wound healing and post inflammatory hyperpigmentation prevention after fractional ablative skin resurfacing: A split-face randomized controlled study. (PubMed)

of the topical EGF ointment on wound healing process and postinflammatory hyperpigmentation (PIH) prevention after fractional ablative laser resurfacing.This is a randomized split-face study. Nineteen healthy subjects were enrolled and completed follow up protocol. Patients received single treatment of fractional carbon dioxide laser on both cheeks. After randomization, each patient was assigned to apply one side of the face with topical EGF ointment and another side with petrolatum. Wound healing (...) The effects of recombinant human epidermal growth factor containing ointment on wound healing and post inflammatory hyperpigmentation prevention after fractional ablative skin resurfacing: A split-face randomized controlled study. Epidermal growth factor (EGF) is one of the important peptides in wound healing process. The effects of EGF have been increasingly studied in various types of ulcers. However, data on postablative laser resurfacing wound is still limited.To evaluate the effects

2019 Journal of cosmetic dermatology

47. Phase 2 clinical study of delgocitinib ointment in pediatric patients with atopic dermatitis. (PubMed)

Phase 2 clinical study of delgocitinib ointment in pediatric patients with atopic dermatitis. Topical delgocitinib (JTE-052), a novel Janus kinase inhibitor, had been shown to be clinically effective in adults with atopic dermatitis (AD). However, the efficacy of topical delgocitinib in pediatric patients with AD remained unclear.We sought to evaluate the efficacy and safety of delgocitinib ointment in pediatric patients with AD.In this phase 2 clinical study (JapicCTI-173553) Japanese patients (...) aged 2 through 15 years with AD were randomized in a 1:1:1 ratio to receive 0.25% or 0.5% delgocitinib ointment or vehicle ointment twice daily for 4 weeks. The primary efficacy end point was the percentage change from baseline in the modified Eczema Area and Severity Index score at the end of treatment (EOT).At EOT, modified Eczema Area and Severity Index scores in both delgocitinib groups were significantly reduced compared with that in the vehicle group. The least-squares mean percentage change

2019 Journal of Allergy and Clinical Immunology

48. Crisaborole 2% ointment for the treatment of intertriginous, anogenital, and facial psoriasis: a double-blind, randomized, vehicle-controlled trial. (PubMed)

Crisaborole 2% ointment for the treatment of intertriginous, anogenital, and facial psoriasis: a double-blind, randomized, vehicle-controlled trial. Psoriasis of the intertriginous, anogenital, and facial regions remains a therapeutic challenge, with current algorithms lacking a topical agent that exhibits both high efficacy and minimal side effects.To assess the safety and efficacy of crisaborole 2% ointment-a nonsteroidal, phosphodiesterase-4 inhibitor-in the treatment of intertriginous (...) , anogenital, and facial psoriasis.A double-blind, randomized, vehicle-controlled trial was conducted in 21 subjects. Subjects were randomized 2:1 to receive 4 weeks of twice daily treatment with either crisaborole 2% ointment (n=14) or vehicle ointment (n=7), followed by 4 weeks of open label treatment with crisaborole 2% ointment. Disease severity was measured using the Target Lesion Severity Scale (TLSS).After 4 weeks, subjects in the crisaborole group demonstrated 66% improvement compared to 9

2019 Journal of American Academy of Dermatology

49. Compounded Topical Diclofenac for the Treatment of Inflammation in Adults: Clinical Effectiveness, Cost-Effectiveness and Guidelines

are the evidence-based guidelines regarding the use of topical diclofenac for the treatment of adults with inflammation? Key Message No relevant literature was identified regarding the use of prescription-strength compounded topical diclofenac for the treatment of adults with inflammation. Tags administration, cutaneous, administration, topical, anti-inflammatory agents, non-steroidal, diclofenac, gels, inflammation, inflammation mediators, ointments, rheumatic diseases, gels, Gel, NSAID, NSAIDs, anti (...) Compounded Topical Diclofenac for the Treatment of Inflammation in Adults: Clinical Effectiveness, Cost-Effectiveness and Guidelines Compounded Topical Diclofenac for the Treatment of Inflammation in Adults: Clinical Effectiveness, Cost-Effectiveness and Guidelines | CADTH.ca Find the information you need Compounded Topical Diclofenac for the Treatment of Inflammation in Adults: Clinical Effectiveness, Cost-Effectiveness and Guidelines Compounded Topical Diclofenac for the Treatment

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

50. Topical Antibiotics for Infection Prevention: A Review of the Clinical Effectiveness and Guidelines

the use of mupirocin in adults undergoing intensive home hemodialysis. One guideline mentioned that the use of silver sulfadiazine in preventing burn wound infection has not been proven. Tags infectious diseases, administration, topical, gramicidin, skin diseases, bacterial, skin diseases, infectious, wound infection, topical ointment, infected wound, skin ulcer Files Rapid Response Summary with Critical Appraisal Published : March 30, 2017 Related Content Follow us: © 2019 Canadian Agency for Drugs (...) Topical Antibiotics for Infection Prevention: A Review of the Clinical Effectiveness and Guidelines Topical Antibiotics for Infection Prevention: A Review of the Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Topical Antibiotics for Infection Prevention: A Review of the Clinical Effectiveness and Guidelines Topical Antibiotics for Infection Prevention: A Review of the Clinical Effectiveness and Guidelines Published on: March 30, 2017 Project Number: RC0854-000

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

51. Topical Antibiotics for Infected Dermatitis: A Review of the Clinical Effectiveness and Guidelines

infected dermatitis. The long-term or routine use of topical antibiotics for infected dermatitis is not recommended. The combination of intranasal mupirocin and bleach bath may be recommended for patients with moderate to severe dermatitis who have signs of secondary bacterial infection. Tags dermatology, administration, topical, bacitracin, dermatitis, gramicidin, mupirocin, silver sulfadiazine, skin diseases, infectious, staphylococcal skin infections, Antibiotic, polymyxin, polysporin, ointment (...) Topical Antibiotics for Infected Dermatitis: A Review of the Clinical Effectiveness and Guidelines Topical Antibiotics for Infected Dermatitis: A Review of the Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Topical Antibiotics for Infected Dermatitis: A Review of the Clinical Effectiveness and Guidelines Topical Antibiotics for Infected Dermatitis: A Review of the Clinical Effectiveness and Guidelines Published on: March 3, 2017 Project Number: RC0852-000 Product

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

52. Topical emollient for preventing infection in preterm infants. (PubMed)

Topical emollient for preventing infection in preterm infants. Breakdown of the developmentally immature epidermal barrier may permit entry for micro-organisms leading to invasive infection in preterm infants. Topical emollients may improve skin integrity and barrier function and thereby prevent invasive infection, a major cause of mortality and morbidity in preterm infants.To assess the effect of topical application of emollients (ointments, creams, or oils) on the incidence of invasive (...) -randomised trials.Randomised or quasi-randomised controlled trials that assessed the effect of prophylactic application of topical emollient (ointments, creams, or oils) on the incidence of invasive infection, mortality, other morbidity, and growth and development in preterm infants.Two review authors assessed trial eligibility and risk of bias and undertook data extraction independently. We analysed the treatment effects in the individual trials and reported the risk ratio and risk difference

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2016 Cochrane

53. Topical antibiotics for preventing surgical site infection in wounds healing by primary intention. (PubMed)

surgery conducted in theatre. Nine different topical antibiotics were included. We included two three-arm trials, two four-arm trials and 10 two-arm trials. The control groups comprised; an alternative topical antibiotic (two studies), topical antiseptic (six studies) and no topical antibiotic (10 studies), which comprised inert ointment (five studies) no treatment (four studies) and one study with one arm of each.The risk of bias of the 14 studies varied. Seven studies were at high risk of bias, five (...) contact dermatitis; there was no clear difference in the risk of dermatitis between topical antibiotics and antiseptics, however this comparison was underpowered and a difference cannot be ruled out (RR 0.97, 95% CI 0.52 to 1.82; very low-quality evidence, downgraded twice for risk of bias and once for imprecision). Topical antibiotic versus topical antibioticOne study (99 participants) compared mupirocin ointment with a combination ointment of neomycin/polymyxin B/bacitracin zinc for the outcome

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2016 Cochrane

54. Efficacy of egg yolk and nitroglycerin ointment as treatments for acute anal fissures: A randomized clinical trial study. (PubMed)

Efficacy of egg yolk and nitroglycerin ointment as treatments for acute anal fissures: A randomized clinical trial study. Acute anal fissure as a common disease in society has several etiologies and manifestations such as severe anal pain and bleeding. Nitroglycerin ointment 0.2% is the most common topical treatment used. The most common side effect of nitroglycerin is headache, which is annoying for patients and often leads to discontinuation of the drug.Comparison of egg yolk as a natural (...) substance with analgesic and anti-inflammatory properties and minimal side effects with nitroglycerin ointment in the treatment of acute anal fissure.This randomized clinical trial was carried out during a 10-day period in the Gastroenterology clinic of Ghaem Hospital, Mashhad, Iran (year 2015). 126 patients who filled the inclusion criteria were enrolled. The patients were randomly divided into two groups. Nitroglycerin ointment (0.2%) was applied by patients in the first group, twice daily for 10 days

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2016 Electronic physician

55. Therapeutic Effect of Tzu-Yun Ointment on Patients with Atopic Dermatitis: A Preliminary, Randomized, Controlled, Open-Label Study. (PubMed)

Therapeutic Effect of Tzu-Yun Ointment on Patients with Atopic Dermatitis: A Preliminary, Randomized, Controlled, Open-Label Study. Atopic dermatitis comprises a group of chronic, relapsing inflammatory conditions. Topical steroids (TS) can ameliorate atopic dermatitis but induce skin atrophy and secondary infection. Tzu-Yun ointment (TYO) was used widely for skin ulcers and pus discharges. This study sought to determine whether TYO can replace TS therapy for atopic dermatitis.This preliminary

2016 Journal of alternative and complementary medicine (New York, N.Y.)

56. An Observational Study Investigating the Treatment Satisfaction of Atopic Dermatitis Patients Who Have Switched to Ointment (W/O Emulsion) Formulation of Very Strong Class Topical Corticosteroids

An Observational Study Investigating the Treatment Satisfaction of Atopic Dermatitis Patients Who Have Switched to Ointment (W/O Emulsion) Formulation of Very Strong Class Topical Corticosteroids An Observational Study Investigating the Treatment Satisfaction of Atopic Dermatitis Patients Who Have Switched to Ointment (W/O Emulsion) Formulation of Very Strong Class Topical Corticosteroids - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer (...) to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. An Observational Study Investigating the Treatment Satisfaction of Atopic Dermatitis Patients Who Have Switched to Ointment (W/O Emulsion) Formulation of Very Strong Class Topical Corticosteroids (Ointment TS-AD) The safety and scientific validity of this study

2015 Clinical Trials

57. COMPARISON OF PAIN CONTROL DURING TRUS GUIDED BIOPSIES BETWEEN BASAL PERI-PROSTATIC LOCAL INFILTRATION ANESTHESIA VERSUS COMBINED TOPICAL ANAL LIGNOCAINE OINTMENT AND LOCAL INFILTRATION ANESTHESIA. (PubMed)

COMPARISON OF PAIN CONTROL DURING TRUS GUIDED BIOPSIES BETWEEN BASAL PERI-PROSTATIC LOCAL INFILTRATION ANESTHESIA VERSUS COMBINED TOPICAL ANAL LIGNOCAINE OINTMENT AND LOCAL INFILTRATION ANESTHESIA. Control of pain associated with TRUS guided biopsies was the target of many researches that tried peri-prostatic local infiltration anesthesia (PLIA) either basal, apical, combined or topical anesthesia (TA). Thus, the efficacy of (PLIA) alone versus (PLIA) combined with (TA) in pain control during (...) TRUS guided biopsies was compared. A total of 163 patients with a mean age±2stdev (61±1.4 years) and a mean PSA ± 2stdev (8.5±1. lng/ml) 84 patients (Gl) were randomized to receive either PLIA alone (Gl) or 79 patients (G2) combined TA (using lignocaine 5% ointment of the anal ring, anal canal, and anterior rectal wall and basal PLIA via injecting 5 ml 2% xylocaine in both sides of the base), with cross-matched mean ages. Patients were asked to scale pain from 0-10 during probe insertion (P1

2015 Journal of the Egyptian Society of Parasitology

58. Effect of topical ophthalmic dorzolamide(2%)-timolol(0.5%) solution and ointment on intraocular pressure in normal horses. (PubMed)

Effect of topical ophthalmic dorzolamide(2%)-timolol(0.5%) solution and ointment on intraocular pressure in normal horses. To compare the effect of commercially available solution and compounded ointment formulations of dorzolamide(2%)-timolol(0.5%) on intraocular pressure (IOP) of normal horses.Eighteen clinically normal horses.A randomized, masked prospective design was used with horses divided into two equal groups. One eye of each horse was selected for topical ophthalmic treatment (...) with either 0.2 mL of dorzolamide(2%)-timolol(0.5%) solution or 0.2 g of dorzolamide(2%)-timolol(0.5%) ointment every 12 h for 5 days. The contralateral eye of horses in both groups was untreated. Rebound tonometry was performed every 6 h starting 2 days prior to and ending 2 days after the treatment period.The mean IOP reduction in eyes treated with the solution or ointment formulations was 13%. Untreated eyes in both groups experienced a lesser but still statistically significant reduction in IOP

2015 Veterinary ophthalmology

59. Study of Safety and Efficacy of Topical GSK2981278 Ointment in Plaque Psoriasis

Study of Safety and Efficacy of Topical GSK2981278 Ointment in Plaque Psoriasis Study of Safety and Efficacy of Topical GSK2981278 Ointment in Plaque Psoriasis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Study of Safety and Efficacy of Topical GSK2981278 Ointment in Plaque Psoriasis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02548052 Recruitment Status : Completed First Posted : September 14, 2015 Last Update Posted : May 15, 2017 Sponsor: GlaxoSmithKline Information provided by (Responsible

2015 Clinical Trials

60. Safety, Tolerability and Therapeutic Efficacy of Topical ZEP-3 Ointment (1.0%) for the Treatment of Cold Sores

Safety, Tolerability and Therapeutic Efficacy of Topical ZEP-3 Ointment (1.0%) for the Treatment of Cold Sores Safety, Tolerability and Therapeutic Efficacy of Topical ZEP-3 Ointment (1.0%) for the Treatment of Cold Sores - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Safety, Tolerability and Therapeutic Efficacy of Topical ZEP-3 Ointment (1.0%) for the Treatment of Cold Sores The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02483182 Recruitment Status : Active, not recruiting First Posted : June 26

2015 Clinical Trials

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