How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

4,013 results for

Topical Ointment

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

41. Dressings and topical agents for treating pressure ulcers. (PubMed)

Dressings and topical agents for treating pressure ulcers. Pressure ulcers, also known as bedsores, decubitus ulcers and pressure injuries, are localised areas of injury to the skin or the underlying tissue, or both. Dressings are widely used to treat pressure ulcers and promote healing, and there are many options to choose from including alginate, hydrocolloid and protease-modulating dressings. Topical agents have also been used as alternatives to dressings in order to promote healing.A clear (...) and current overview of all the evidence is required to facilitate decision-making regarding the use of dressings or topical agents for the treatment of pressure ulcers. Such a review would ideally help people with pressure ulcers and health professionals assess the best treatment options. This review is a network meta-analysis (NMA) which assesses the probability of complete ulcer healing associated with alternative dressings and topical agents.To assess the effects of dressings and topical agents

Full Text available with Trip Pro

2017 Cochrane

42. Topical phenytoin for treating pressure ulcers. (PubMed)

including dressings, ointments and creams such as bacitracin, silver sulphadiazine, neomycin, and phenytoin. Phenytoin is a drug more commonly used in the treatment of epilepsy, but may play an important role in accelerating ulcer healing.To assess the effects of topical phenytoin on the rate of healing of pressure ulcers of any grade, in any care setting.In September 2016, we searched the following electronic databases to identify relevant randomized clinical trials: the Cochrane Wounds Specialised (...) : hydrocolloid dressings, triple antibiotic ointment and simple dressings. In the three RCTs, 79% of participants had grade II ulcers, and 21% of participants had grade I ulcers; no participants had grade III or IV ulcers. Two RCTs had a high risk of bias overall and the other RCT was at unclear risk of bias due to poor reporting. Two RCTs had three intervention arms and the other had two intervention arms.Two studies compared topical phenytoin with hydrocolloid dressing (84 participants analysed

2017 Cochrane

43. Comparison of Collagenase Santyl Ointment With Antibiotic Ointment in the Outpatient Care of Minor Partial Thickness Burns

Pharmacopeia (USP). Sham Comparator: Bacitracin Applied topically (2 mm thickness) once daily Drug: Bacitracin One gram is equal to 500 bacitracin units; one unit of bacitracin is equivalent to 0.026 milligrams. Other Name: Bacitracin Zinc Ointment Outcome Measures Go to Primary Outcome Measures : Proportion Healed [ Time Frame: 21 Days After Treatment ] Outcome will be reported as percent of wound epithelialization. Secondary Outcome Measures : Scar Appearance using the Vancouver Scar Scale [ Time Frame (...) Comparison of Collagenase Santyl Ointment With Antibiotic Ointment in the Outpatient Care of Minor Partial Thickness Burns Comparison of Collagenase Santyl Ointment With Antibiotic Ointment in the Outpatient Care of Minor Partial Thickness Burns - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2016 Clinical Trials

44. The effects of recombinant human epidermal growth factor containing ointment on wound healing and post inflammatory hyperpigmentation prevention after fractional ablative skin resurfacing: A split-face randomized controlled study. (PubMed)

of the topical EGF ointment on wound healing process and postinflammatory hyperpigmentation (PIH) prevention after fractional ablative laser resurfacing.This is a randomized split-face study. Nineteen healthy subjects were enrolled and completed follow up protocol. Patients received single treatment of fractional carbon dioxide laser on both cheeks. After randomization, each patient was assigned to apply one side of the face with topical EGF ointment and another side with petrolatum. Wound healing (...) The effects of recombinant human epidermal growth factor containing ointment on wound healing and post inflammatory hyperpigmentation prevention after fractional ablative skin resurfacing: A split-face randomized controlled study. Epidermal growth factor (EGF) is one of the important peptides in wound healing process. The effects of EGF have been increasingly studied in various types of ulcers. However, data on postablative laser resurfacing wound is still limited.To evaluate the effects

2019 Journal of cosmetic dermatology

45. Compounded Topical Diclofenac for the Treatment of Inflammation in Adults: Clinical Effectiveness, Cost-Effectiveness and Guidelines

are the evidence-based guidelines regarding the use of topical diclofenac for the treatment of adults with inflammation? Key Message No relevant literature was identified regarding the use of prescription-strength compounded topical diclofenac for the treatment of adults with inflammation. Tags administration, cutaneous, administration, topical, anti-inflammatory agents, non-steroidal, diclofenac, gels, inflammation, inflammation mediators, ointments, rheumatic diseases, gels, Gel, NSAID, NSAIDs, anti (...) Compounded Topical Diclofenac for the Treatment of Inflammation in Adults: Clinical Effectiveness, Cost-Effectiveness and Guidelines Compounded Topical Diclofenac for the Treatment of Inflammation in Adults: Clinical Effectiveness, Cost-Effectiveness and Guidelines | CADTH.ca Find the information you need Compounded Topical Diclofenac for the Treatment of Inflammation in Adults: Clinical Effectiveness, Cost-Effectiveness and Guidelines Compounded Topical Diclofenac for the Treatment

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

46. Topical Antibiotics for Infection Prevention: A Review of the Clinical Effectiveness and Guidelines

the use of mupirocin in adults undergoing intensive home hemodialysis. One guideline mentioned that the use of silver sulfadiazine in preventing burn wound infection has not been proven. Tags infectious diseases, administration, topical, gramicidin, skin diseases, bacterial, skin diseases, infectious, wound infection, topical ointment, infected wound, skin ulcer Files Rapid Response Summary with Critical Appraisal Published : March 30, 2017 Related Content Follow us: © 2019 Canadian Agency for Drugs (...) Topical Antibiotics for Infection Prevention: A Review of the Clinical Effectiveness and Guidelines Topical Antibiotics for Infection Prevention: A Review of the Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Topical Antibiotics for Infection Prevention: A Review of the Clinical Effectiveness and Guidelines Topical Antibiotics for Infection Prevention: A Review of the Clinical Effectiveness and Guidelines Published on: March 30, 2017 Project Number: RC0854-000

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

47. Topical Antibiotics for Infected Dermatitis: A Review of the Clinical Effectiveness and Guidelines

infected dermatitis. The long-term or routine use of topical antibiotics for infected dermatitis is not recommended. The combination of intranasal mupirocin and bleach bath may be recommended for patients with moderate to severe dermatitis who have signs of secondary bacterial infection. Tags dermatology, administration, topical, bacitracin, dermatitis, gramicidin, mupirocin, silver sulfadiazine, skin diseases, infectious, staphylococcal skin infections, Antibiotic, polymyxin, polysporin, ointment (...) Topical Antibiotics for Infected Dermatitis: A Review of the Clinical Effectiveness and Guidelines Topical Antibiotics for Infected Dermatitis: A Review of the Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Topical Antibiotics for Infected Dermatitis: A Review of the Clinical Effectiveness and Guidelines Topical Antibiotics for Infected Dermatitis: A Review of the Clinical Effectiveness and Guidelines Published on: March 3, 2017 Project Number: RC0852-000 Product

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

48. Topical emollient for preventing infection in preterm infants. (PubMed)

Topical emollient for preventing infection in preterm infants. Breakdown of the developmentally immature epidermal barrier may permit entry for micro-organisms leading to invasive infection in preterm infants. Topical emollients may improve skin integrity and barrier function and thereby prevent invasive infection, a major cause of mortality and morbidity in preterm infants.To assess the effect of topical application of emollients (ointments, creams, or oils) on the incidence of invasive (...) -randomised trials.Randomised or quasi-randomised controlled trials that assessed the effect of prophylactic application of topical emollient (ointments, creams, or oils) on the incidence of invasive infection, mortality, other morbidity, and growth and development in preterm infants.Two review authors assessed trial eligibility and risk of bias and undertook data extraction independently. We analysed the treatment effects in the individual trials and reported the risk ratio and risk difference

Full Text available with Trip Pro

2016 Cochrane

49. Topical antibiotics for preventing surgical site infection in wounds healing by primary intention. (PubMed)

surgery conducted in theatre. Nine different topical antibiotics were included. We included two three-arm trials, two four-arm trials and 10 two-arm trials. The control groups comprised; an alternative topical antibiotic (two studies), topical antiseptic (six studies) and no topical antibiotic (10 studies), which comprised inert ointment (five studies) no treatment (four studies) and one study with one arm of each.The risk of bias of the 14 studies varied. Seven studies were at high risk of bias, five (...) contact dermatitis; there was no clear difference in the risk of dermatitis between topical antibiotics and antiseptics, however this comparison was underpowered and a difference cannot be ruled out (RR 0.97, 95% CI 0.52 to 1.82; very low-quality evidence, downgraded twice for risk of bias and once for imprecision). Topical antibiotic versus topical antibioticOne study (99 participants) compared mupirocin ointment with a combination ointment of neomycin/polymyxin B/bacitracin zinc for the outcome

Full Text available with Trip Pro

2016 Cochrane

50. Efficacy of egg yolk and nitroglycerin ointment as treatments for acute anal fissures: A randomized clinical trial study. (PubMed)

Efficacy of egg yolk and nitroglycerin ointment as treatments for acute anal fissures: A randomized clinical trial study. Acute anal fissure as a common disease in society has several etiologies and manifestations such as severe anal pain and bleeding. Nitroglycerin ointment 0.2% is the most common topical treatment used. The most common side effect of nitroglycerin is headache, which is annoying for patients and often leads to discontinuation of the drug.Comparison of egg yolk as a natural (...) substance with analgesic and anti-inflammatory properties and minimal side effects with nitroglycerin ointment in the treatment of acute anal fissure.This randomized clinical trial was carried out during a 10-day period in the Gastroenterology clinic of Ghaem Hospital, Mashhad, Iran (year 2015). 126 patients who filled the inclusion criteria were enrolled. The patients were randomly divided into two groups. Nitroglycerin ointment (0.2%) was applied by patients in the first group, twice daily for 10 days

Full Text available with Trip Pro

2016 Electronic physician

51. Therapeutic Effect of Tzu-Yun Ointment on Patients with Atopic Dermatitis: A Preliminary, Randomized, Controlled, Open-Label Study. (PubMed)

Therapeutic Effect of Tzu-Yun Ointment on Patients with Atopic Dermatitis: A Preliminary, Randomized, Controlled, Open-Label Study. Atopic dermatitis comprises a group of chronic, relapsing inflammatory conditions. Topical steroids (TS) can ameliorate atopic dermatitis but induce skin atrophy and secondary infection. Tzu-Yun ointment (TYO) was used widely for skin ulcers and pus discharges. This study sought to determine whether TYO can replace TS therapy for atopic dermatitis.This preliminary

2016 Journal of alternative and complementary medicine (New York, N.Y.)

52. An Observational Study Investigating the Treatment Satisfaction of Atopic Dermatitis Patients Who Have Switched to Ointment (W/O Emulsion) Formulation of Very Strong Class Topical Corticosteroids

An Observational Study Investigating the Treatment Satisfaction of Atopic Dermatitis Patients Who Have Switched to Ointment (W/O Emulsion) Formulation of Very Strong Class Topical Corticosteroids An Observational Study Investigating the Treatment Satisfaction of Atopic Dermatitis Patients Who Have Switched to Ointment (W/O Emulsion) Formulation of Very Strong Class Topical Corticosteroids - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer (...) to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. An Observational Study Investigating the Treatment Satisfaction of Atopic Dermatitis Patients Who Have Switched to Ointment (W/O Emulsion) Formulation of Very Strong Class Topical Corticosteroids (Ointment TS-AD) The safety and scientific validity of this study

2015 Clinical Trials

53. COMPARISON OF PAIN CONTROL DURING TRUS GUIDED BIOPSIES BETWEEN BASAL PERI-PROSTATIC LOCAL INFILTRATION ANESTHESIA VERSUS COMBINED TOPICAL ANAL LIGNOCAINE OINTMENT AND LOCAL INFILTRATION ANESTHESIA. (PubMed)

COMPARISON OF PAIN CONTROL DURING TRUS GUIDED BIOPSIES BETWEEN BASAL PERI-PROSTATIC LOCAL INFILTRATION ANESTHESIA VERSUS COMBINED TOPICAL ANAL LIGNOCAINE OINTMENT AND LOCAL INFILTRATION ANESTHESIA. Control of pain associated with TRUS guided biopsies was the target of many researches that tried peri-prostatic local infiltration anesthesia (PLIA) either basal, apical, combined or topical anesthesia (TA). Thus, the efficacy of (PLIA) alone versus (PLIA) combined with (TA) in pain control during (...) TRUS guided biopsies was compared. A total of 163 patients with a mean age±2stdev (61±1.4 years) and a mean PSA ± 2stdev (8.5±1. lng/ml) 84 patients (Gl) were randomized to receive either PLIA alone (Gl) or 79 patients (G2) combined TA (using lignocaine 5% ointment of the anal ring, anal canal, and anterior rectal wall and basal PLIA via injecting 5 ml 2% xylocaine in both sides of the base), with cross-matched mean ages. Patients were asked to scale pain from 0-10 during probe insertion (P1

2015 Journal of the Egyptian Society of Parasitology

54. Effect of topical ophthalmic dorzolamide(2%)-timolol(0.5%) solution and ointment on intraocular pressure in normal horses. (PubMed)

Effect of topical ophthalmic dorzolamide(2%)-timolol(0.5%) solution and ointment on intraocular pressure in normal horses. To compare the effect of commercially available solution and compounded ointment formulations of dorzolamide(2%)-timolol(0.5%) on intraocular pressure (IOP) of normal horses.Eighteen clinically normal horses.A randomized, masked prospective design was used with horses divided into two equal groups. One eye of each horse was selected for topical ophthalmic treatment (...) with either 0.2 mL of dorzolamide(2%)-timolol(0.5%) solution or 0.2 g of dorzolamide(2%)-timolol(0.5%) ointment every 12 h for 5 days. The contralateral eye of horses in both groups was untreated. Rebound tonometry was performed every 6 h starting 2 days prior to and ending 2 days after the treatment period.The mean IOP reduction in eyes treated with the solution or ointment formulations was 13%. Untreated eyes in both groups experienced a lesser but still statistically significant reduction in IOP

2015 Veterinary ophthalmology

55. Study of Safety and Efficacy of Topical GSK2981278 Ointment in Plaque Psoriasis

Study of Safety and Efficacy of Topical GSK2981278 Ointment in Plaque Psoriasis Study of Safety and Efficacy of Topical GSK2981278 Ointment in Plaque Psoriasis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Study of Safety and Efficacy of Topical GSK2981278 Ointment in Plaque Psoriasis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02548052 Recruitment Status : Completed First Posted : September 14, 2015 Last Update Posted : May 15, 2017 Sponsor: GlaxoSmithKline Information provided by (Responsible

2015 Clinical Trials

56. Safety, Tolerability and Therapeutic Efficacy of Topical ZEP-3 Ointment (1.0%) for the Treatment of Cold Sores

Safety, Tolerability and Therapeutic Efficacy of Topical ZEP-3 Ointment (1.0%) for the Treatment of Cold Sores Safety, Tolerability and Therapeutic Efficacy of Topical ZEP-3 Ointment (1.0%) for the Treatment of Cold Sores - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Safety, Tolerability and Therapeutic Efficacy of Topical ZEP-3 Ointment (1.0%) for the Treatment of Cold Sores The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02483182 Recruitment Status : Active, not recruiting First Posted : June 26

2015 Clinical Trials

57. A Phase 2, Randomized, Controlled, Dose-Ranging Study Evaluating Crisaborole Topical Ointment, 0.5% and 2% in Adolescents With Mild to Moderate Atopic Dermatitis. (PubMed)

A Phase 2, Randomized, Controlled, Dose-Ranging Study Evaluating Crisaborole Topical Ointment, 0.5% and 2% in Adolescents With Mild to Moderate Atopic Dermatitis. Crisaborole is a novel, boron-based, small-molecule, topical phosphodiesterase-4 inhibitor in development for the treatment of patients with mild to moderate atopic dermatitis (AD).In this multicenter, randomized, double-blind, dose-ranging, phase 2 study, adolescent patients 12 to 17 years of age with mild to moderate AD and 2 (...) distinct target AD lesions were randomized to once-daily (QD) or twice-daily (BID) treatment with crisaborole topical ointment. For each patient, 2 target lesions were randomized to receive 29 days of treatment with 0.5% or 2% crisaborole topical ointment. The primary endpoint was change from baseline in AD severity index (ADSI) score for each lesion. Exploratory efficacy endpoints and safety were also assessed.A total of 86 patients were enrolled and received crisaborole topical ointment 0.5% or 2% QD

2015 Journal of drugs in dermatology : JDD

58. Crisaborole Topical Ointment, 2% in Adults With Atopic Dermatitis: A Phase 2a, Vehicle-Controlled, Proof-of-Concept Study. (PubMed)

Crisaborole Topical Ointment, 2% in Adults With Atopic Dermatitis: A Phase 2a, Vehicle-Controlled, Proof-of-Concept Study. A novel approach for treating atopic dermatitis (AD) is the inhibition of phosphodiesterase 4 (PDE4), an enzyme involved in the proinflammatory cascade. Crisaborole topical ointment, 2% is a novel, boron-based small-molecule PDE4 inhibitor with anti-inflammatory properties. The objective of this proof-of-concept study was to assess the efficacy and safety of crisaborole (...) topical ointment, 2% in adults with mild to moderate AD.This phase 2a, randomized, double-blind, bilateral, 6-week study of crisaborole topical ointment, 2% was conducted in adult patients with mild to moderate AD with 2 comparable target AD lesions. Patients were randomly assigned to twice-daily application of crisaborole topical ointment, 2% or vehicle, each to 1 of the 2 target lesions. The primary efficacy endpoint was change from baseline in Atopic Dermatitis Severity Index (ADSI) score at day 28

2015 Journal of drugs in dermatology : JDD

59. Topical combination therapy with vitamin D3 and corticosteroid ointment for palmoplantar pustulosis: A prospective, randomized, left-right comparison study. (PubMed)

Topical combination therapy with vitamin D3 and corticosteroid ointment for palmoplantar pustulosis: A prospective, randomized, left-right comparison study. Vitamin D3 ointment and corticosteroid ointment are both used for the treatment of palmoplantar pustulosis (PPP). However, to date there is no systematic study of the efficacy of combination therapy for the treatment of PPP.We compared the efficacy of a topical combination therapy with vitamin D3 and a topical corticosteroid (...) with that of topical corticosteroid alone in the treatment of PPP.We evaluated left-right comparison study of the efficacy of a combination therapy consisting of maxacalcitol ointment and betamethasone butyrate propionate ointment (BBP), and monotherapy with BBP alone in 27 patients with PPP for 8 weeks.The improvement in the symptom (erythema, pustules/vesicles, hyperkeratosis/scales) scores was high for the combination therapy. In particular, the improvement rate for pustules/vesicles at week 8 after

2015 The Journal of dermatological treatment

60. A Study to Evaluate the Safety and Efficacy of Topically Applied TV 45070 Ointment in Patients With Postherpetic Neuralgia (PHN)

A Study to Evaluate the Safety and Efficacy of Topically Applied TV 45070 Ointment in Patients With Postherpetic Neuralgia (PHN) A Study to Evaluate the Safety and Efficacy of Topically Applied TV 45070 Ointment in Patients With Postherpetic Neuralgia (PHN) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have (...) reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study to Evaluate the Safety and Efficacy of Topically Applied TV 45070 Ointment in Patients With Postherpetic Neuralgia (PHN) ((PHN)) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02365636

2015 Clinical Trials

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>