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Topical Ointment

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4001. Successful treatment of acrodermatitis continua suppurativa with topical tacrolimus 0.1% ointment. (PubMed)

Successful treatment of acrodermatitis continua suppurativa with topical tacrolimus 0.1% ointment. Acrodermatitis continua suppurativa of Hallopeau (ACS) is a rare pustular variant of psoriasis in which numerous treatment modalities have been used without any consistent long-term effect. We report for the first time two patients with ACS which was successfully treated with topical tacrolimus 0.1% ointment. Our observations raise hopes that this new treatment strategy for ACS may constitute

2004 British Journal of Dermatology

4002. Blinded side-to-side comparison of topical corticosteroid and tacrolimus ointment in children with moderate to severe atopic dermatitis. (PubMed)

Blinded side-to-side comparison of topical corticosteroid and tacrolimus ointment in children with moderate to severe atopic dermatitis. There is little information on the relative efficacy of topical tacrolimus and corticosteroids in the treatment of atopic dermatitis (AD) in children. In a single-centre, prospective, observer-blinded, side-to-side comparative study (ISRCTN65507338), 96 children with moderately severe AD were enrolled. The study aimed to compare the relative effectiveness (...) of the child's usual topical corticosteroid with 0.03% tacrolimus ointment applied for 1 week, and if there was no difference, 0.1% tacrolimus ointment applied for a further week. Topical tacrolimus was found to be more effective than topical corticosteroid in 72 of the 93 children (77%) who completed the study. Using multiple-regression analysis with age, gender, pretreatment surface area affected and pretreatment corticosteroid potency as covariants, the only factor that reduced the chance of observing

2007 Clinical & Experimental Dermatology

4003. Topical application of FK506 (tacrolimus) ointment inhibits mite antigen-induced dermatitis by local action in NC/Nga mice. (PubMed)

Topical application of FK506 (tacrolimus) ointment inhibits mite antigen-induced dermatitis by local action in NC/Nga mice. FK506 ointment (tacrolimus ointment, protopic) is a new drug therapeutically effective for patients with atopic dermatitis (AD). However, the mechanism of action of FK506 ointment on AD is not fully understood.We examined the effect of FK506 ointment on mite antigen-induced dermatitis in NC/Nga mice. Clinical symptoms and ear thickness were recorded, and histopathological (...) studies and in vitro analyses were performed.Topical application of FK506 ointment (0.03-0.3%) suppressed the development of dermatitis. In the lesional skin, both interleukin (IL)-4 and interferon (IFN)-gamma were detected, even though the IL-4+/IFN-gamma- T helper 2 (Th2) population was predominant in the regional lymph nodes (LNs). Topical application of FK506 treatment reduced the elevated level of both IL-4 and IFN-gamma in the skin, but did not decrease the expansion of the Th2 population

2004 International Archives of Allergy and Immunology

4004. Clobetasol propionate ointment once daily versus fluocinonide ointment three times daily in psoriasis. (PubMed)

RS Sturm H M HM eng Clinical Trial Comparative Study Controlled Clinical Trial Journal Article Randomized Controlled Trial England Int J Dermatol 0243704 0011-9059 0 Ointments 0CD5FD6S2M Fluocinolone Acetonide 2W4A77YPAN Fluocinonide 9842X06Q6M Betamethasone ADN79D536H Clobetasol IM Administration, Topical Betamethasone analogs & derivatives Clinical Trials as Topic Clobetasol administration & dosage analogs & derivatives Drug Administration Schedule Fluocinolone Acetonide analogs & derivatives (...) Clobetasol propionate ointment once daily versus fluocinonide ointment three times daily in psoriasis. 3278991 1988 04 15 2013 11 21 0011-9059 27 1 1988 Jan-Feb International journal of dermatology Int. J. Dermatol. Clobetasol propionate ointment once daily versus fluocinonide ointment three times daily in psoriasis. 54-5 Bickers D D Department of Dermatology, Case Western Reserve University, School of Medicine, Cleveland, Ohio. Cornell R R Kamm A R AR Bauman W E WE Handler R M RM Medansky R S

1988 International Journal of Dermatology

4005. Alcometasone dipropionate 0.05% ointment versus hydrocortisone 1.0% ointment in eczema & other dermatoses. (PubMed)

0370750 0019-5154 0 Anti-Inflammatory Agents 0 Ointments S56PQL4N1V alclometasone dipropionate WI4X0X7BPJ Hydrocortisone X4W7ZR7023 Methylprednisolone IM Administration, Topical Adolescent Adult Aged Anti-Inflammatory Agents therapeutic use Child Clinical Trials as Topic Double-Blind Method Eczema drug therapy Female Humans Hydrocortisone Male Methylprednisolone analogs & derivatives therapeutic use Middle Aged Ointments Random Allocation Skin Diseases drug therapy 1988 1 1 1988 1 1 0 1 1988 1 1 0 0 (...) Alcometasone dipropionate 0.05% ointment versus hydrocortisone 1.0% ointment in eczema & other dermatoses. 3074045 1989 07 13 2017 11 16 0019-5154 33 1 1988 Jan Indian journal of dermatology Indian J Dermatol Alcometasone dipropionate 0.05% ointment versus hydrocortisone 1.0% ointment in eczema & other dermatoses. 5-8 Handa F F Sharma P K PK Guha A A Sharma S D SD eng Clinical Trial Comparative Study Controlled Clinical Trial Journal Article Randomized Controlled Trial India Indian J Dermatol

1989 Indian journal of dermatology

4006. Mometasone furoate ointment 0.1% vs. hydrocortisone ointment 1.0% in psoriasis. Atrophogenic potential. (PubMed)

Comparative Study Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't England Int J Dermatol 0243704 0011-9059 0 Anti-Inflammatory Agents 0 Ointments 0 Pregnadienediols 04201GDN4R Mometasone Furoate WI4X0X7BPJ Hydrocortisone IM Administration, Topical Adult Aged Anti-Inflammatory Agents administration & dosage adverse effects therapeutic use Atrophy chemically induced Female Humans Hydrocortisone Male Middle Aged Mometasone Furoate Ointments Pregnadienediols administration (...) Mometasone furoate ointment 0.1% vs. hydrocortisone ointment 1.0% in psoriasis. Atrophogenic potential. 2753592 1989 08 31 2015 11 19 0011-9059 28 5 1989 Jun International journal of dermatology Int. J. Dermatol. Mometasone furoate ointment 0.1% vs. hydrocortisone ointment 1.0% in psoriasis. Atrophogenic potential. 342-4 Katz H I HI Department of Dermatology, University of Minnesota School of Medicine, Minneapolis. Prawer S E SE Watson M J MJ Scull T A TA Peets E A EA eng Clinical Trial

1989 International Journal of Dermatology

4007. Double-blind, right/left comparison of calcipotriol ointment and betamethasone ointment in the treatment of Prurigo nodularis. (PubMed)

Anti-Inflammatory Agents 0 Dermatologic Agents 0 Glucocorticoids 0 Ointments 143NQ3779B calcipotriene 9842X06Q6M Betamethasone FXC9231JVH Calcitriol AIM IM Administration, Topical Adolescent Adult Anti-Inflammatory Agents administration & dosage Betamethasone administration & dosage Calcitriol administration & dosage analogs & derivatives Child Dermatologic Agents administration & dosage Double-Blind Method Female Glucocorticoids Humans Leg Dermatoses diagnosis drug therapy Male Middle Aged (...) Double-blind, right/left comparison of calcipotriol ointment and betamethasone ointment in the treatment of Prurigo nodularis. 10871962 2000 07 10 2014 11 20 0003-987X 136 6 2000 Jun Archives of dermatology Arch Dermatol Double-blind, right/left comparison of calcipotriol ointment and betamethasone ointment in the treatment of Prurigo nodularis. 807-8 Wong S S SS Goh C L CL eng Clinical Trial Comparative Study Letter Randomized Controlled Trial United States Arch Dermatol 0372433 0003-987X 0

2000 Archives of Dermatology

4008. [Non-halogenated glucocorticoids. A clinical comparison between budesonide 0,025% ointment and desonide 0,1% ointment in psoriasis]. (PubMed)

Comparative Study Controlled Clinical Trial English Abstract Journal Article Randomized Controlled Trial Ikke-halogenerte glukokortikoider. En klinisk sammenligning mellom budesonid 0,025% salve og desonid 0,1% salve ved psoriasis. Norway Tidsskr Nor Laegeforen 0413423 0029-2001 0 Ointments 0 Pregnadienetriols 0 Pregnenediones 51333-22-3 Budesonide J280872D1O Desonide IM Adolescent Adult Aged Budesonide Child Clinical Trials as Topic Desonide therapeutic use Double-Blind Method Female Humans Male Middle (...) [Non-halogenated glucocorticoids. A clinical comparison between budesonide 0,025% ointment and desonide 0,1% ointment in psoriasis]. 6349008 1983 09 20 2013 11 21 0029-2001 103 15 1983 May 30 Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke Tidsskr. Nor. Laegeforen. [Non-halogenated glucocorticoids. A clinical comparison between budesonide 0,025% ointment and desonide 0,1% ointment in psoriasis]. 1266-8 Granholt A A Malmsten L A LA nor Clinical Trial

1983 Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

4009. A comparison of fluticasone propionate ointment, 0.005%, and hydrocortisone-17-butyrate ointment, 0.1%, in the treatment of psoriasis. (PubMed)

A comparison of fluticasone propionate ointment, 0.005%, and hydrocortisone-17-butyrate ointment, 0.1%, in the treatment of psoriasis. The efficacy and safety of twice-daily topical application of fluticasone propionate ointment, 0.005%, and hydrocortisone-17-butyrate ointment, 0.1%, were compared in 113 adult patients with moderate-to-severe psoriasis in a multicenter, double-blind, randomized, parallel study. The majority of patients had psoriatic involvement of long duration over a large (...) body surface area (mean, 17%). The following efficacy assessments were made at weekly intervals for up to four weeks following initiation of treatment: physician's gross assessment of clinical response of the target lesion; severity of psoriatic signs and symptoms; and patients' assessment of treatment effects. Safety was assessed by monitoring and reporting any adverse events that occurred during the study. Fluticasone propionate ointment, 0.005%, was found to be therapeutically superior

1996 Cutis; cutaneous medicine for the practitioner

4010. Comparative study of calcipotriol (MC 903) ointment and betamethasone 17-valerate ointment in patients with psoriasis vulgaris. (PubMed)

Comparative study of calcipotriol (MC 903) ointment and betamethasone 17-valerate ointment in patients with psoriasis vulgaris. Topical vitamin D analogues have been reported to be an effective treatment in patients with psoriasis. Comparative studies with existing treatments are required.Our purpose was to compare the effectiveness of calcipotriol (50 micrograms/gm) and betamethasone 17-valerate (1 mg/gm) ointments twice daily in the treatment of stable plaque psoriasis.This study (...) of patient assessment at 6 weeks showed clearance or marked improvement in 61.2% of the calcipotriol patients and 50.5% with betamethasone (95% CI 1.4 to 20.8). Calcipotriol produced significantly more local side effects (19.5% compared with 3.9%, p less than 0.001); however, these were minimal leading to withdrawal in only 3 of 205 patients.Calcipotriol ointment was as effective as betamethasone 17-valerate ointment as measured by the PASI and superior as measured by self-assessment in patients

1992 Journal of the American Academy of Dermatology

4011. Mometasone furoate 0.1%-salicylic acid 5% ointment versus mometasone furoate 0.1% ointment in the treatment of moderate-to-severe psoriasis: a multicenter study. (PubMed)

Mometasone furoate 0.1%-salicylic acid 5% ointment versus mometasone furoate 0.1% ointment in the treatment of moderate-to-severe psoriasis: a multicenter study. Topical corticosteroids and keratolytics are both used widely in the management of patients with psoriasis. A combination of the two types of agents may provide enhanced relief. The purpose of this study was to compare the efficacy and safety of the combination ointment mometasone furoate 0.1% plus salicylic acid 5 (...) % with that of mometasone furoate 0.1% ointment in the treatment of moderate-to-severe psoriasis vulgaris. A total of 408 patients were enrolled in this controlled, randomized, double-masked, parallel-group, multicenter comparison. Patients applied either mometasone furoate-salicylic acid ointment or mometasone furoate ointment alone to target lesions twice daily for 21 days. Severity of erythema, induration, and scaling were scored at baseline and at days 4, 8, 15, and 22. An evaluation of overall change in disease

1998 Clinical therapeutics

4012. Double-blind clinical trial of 0.05% clobetasol propionate (corrected from proprionate) ointment in orabase and 0.05% fluocinonide ointment in orabase in the treatment of patients with oral vesiculoerosive diseases. (PubMed)

Double-blind clinical trial of 0.05% clobetasol propionate (corrected from proprionate) ointment in orabase and 0.05% fluocinonide ointment in orabase in the treatment of patients with oral vesiculoerosive diseases. Because of their chronic nature treatment of oral vesiculoerosive diseases remains a challenge to the oral medicine specialist. Even though oral vesiculoerosive diseases respond well to systemic steroids, adverse side effects sometimes limit their use. Potent topical steroids (...) are becoming increasingly useful to treat these chronic conditions with good control. The purpose of this double-blind clinical trial was to compare clobetasol propionate and fluocinonide ointment in orabase as treatments for controlling oral vesiculoerosive diseases. Sixty patients were asked to participate (43 women and 17 men). Data are reported for 55 patients. Each patient was seen at baseline and at days 7, 14, 21, and 28. Variables evaluated were pain, erythema, atrophy, and size of lesion. Overall

1994 Oral surgery, oral medicine, and oral pathology

4013. Diflorasone diacetate ointment 0.05% versus betamethasone dipropionate ointment 0.05% in moderate-severe plaque-type psoriasis. (PubMed)

Diflorasone diacetate ointment 0.05% versus betamethasone dipropionate ointment 0.05% in moderate-severe plaque-type psoriasis. We report the results of a 2-week double-blind, parallel clinical trial comparing two superpotent topical glucocorticosteroid ointments, diflorasone diacetate 0.05% and betamethasone dipropionate 0.05%, in psoriatic adults. Both corticosteroid ointments were fast acting and highly efficacious. 40 of the 44 patients who initially enrolled completed the trial. There were

1993 Dermatology (Basel, Switzerland)

4014. Calcipotriene ointment and halobetasol ointment in the long-term treatment of psoriasis: effects on the duration of improvement. (PubMed)

Calcipotriene ointment and halobetasol ointment in the long-term treatment of psoriasis: effects on the duration of improvement. Weekend therapy with superpotent topical corticosteroids has been used for the long-term treatment of psoriasis. Recently, calcipotriene ointment has been added to this regimen for use on weekdays, but there are no long-term studies of that combination.The purpose of this study was to determine whether the addition of weekday calcipotriene to a pulse therapy regimen (...) of weekend superpotent corticosteroids results in a longer duration of remission of plaque psoriasis.This was a double-blind, placebo-controlled, parallel-group study. Forty-four patients with mild to moderate psoriasis were treated with calcipotriene ointment in the morning and halobetasol ointment in the evening for 2 weeks. Thereafter, 40 patients who were at least moderately (50% or greater) improved were randomized to 2 treatment groups. After 2 weeks of treatment with calcipotriene ointment

1998 Journal of the American Academy of Dermatology

4015. Efficacy and safety of tacrolimus ointment compared with that of hydrocortisone butyrate ointment in adult patients with atopic dermatitis. (PubMed)

Efficacy and safety of tacrolimus ointment compared with that of hydrocortisone butyrate ointment in adult patients with atopic dermatitis. Vehicle-controlled studies have demonstrated the efficacy and safety of tacrolimus ointment for patients with atopic dermatitis.This study was undertaken to compare 0.03% and 0.1% tacrolimus ointment with 0.1% hydrocortisone-17-butyrate ointment, a midpotent to potent topical corticosteroid, in the treatment of adult patients with moderate-to-severe atopic (...) dermatitis.Patients applied ointment twice daily to all affected areas for 3 weeks in this multicenter, randomized, double-blind, parallel-group study. The primary endpoint was the modified eczema area and severity index (mEASI) mean area under the curve as a percentage of baseline.Five hundred seventy patients were randomized and received treatment. Discontinuations included 22 of 193 patients from the 0.03% tacrolimus group, 22 of 191 patients from the 0.1% tacrolimus group, and 17 of 186 patients from

2002 The Journal of allergy and clinical immunology

4016. Comparative study of calcipotriene (MC 903) ointment and fluocinonide ointment in the treatment of psoriasis. (PubMed)

Comparative study of calcipotriene (MC 903) ointment and fluocinonide ointment in the treatment of psoriasis. The topical vitamin D analogue calcipotriene has been reported to be an effective treatment for patients with psoriasis. Comparative studies with topical steroids are informative in judging this new therapy.The purpose of this study was to evaluate the efficacy and safety of calcipotriene ointment 0.005% versus fluocinonide ointment 0.05% in the treatment of plaque psoriasis.This study

1994 Journal of the American Academy of Dermatology

4017. A comparison of clobetasol propionate 0.05 percent ointment and an optimized betamethasone dipropionate 0.05 percent ointment in the treatment of psoriasis. (PubMed)

A comparison of clobetasol propionate 0.05 percent ointment and an optimized betamethasone dipropionate 0.05 percent ointment in the treatment of psoriasis. A multicenter, double-blind study compared the effectiveness of two highly potent topical corticosteroids in patients with moderate to severe signs of psoriasis. Left/right paired comparisons of clobetasol propionate ointment 0.05 percent, and an optimized formulation of betamethasone dipropionate ointment 0.05 percent, were made in 130 (...) patients with roughly symmetrical psoriatic lesions. The ointments were applied by the patients twice daily, without occlusion, for two weeks. Both drugs were shown to be highly effective and were well tolerated. Significantly more patients showed greater improvement on the side treated with clobetasol propionate. Follow-up evaluation two weeks after the treatment period showed statistically significant (p less than 0.001) longer remissions resulting from the use of clobetasol propionate.

1986 Cutis; cutaneous medicine for the practitioner

4018. Studies on the efficacy and adrenal effects of Diprolene ointment 0.05 percent and Dermovate ointment 0.05 percent in patients with psoriasis or other resistant dermatoses. (PubMed)

Studies on the efficacy and adrenal effects of Diprolene ointment 0.05 percent and Dermovate ointment 0.05 percent in patients with psoriasis or other resistant dermatoses. The efficacy of Diprolene ointment 0.05 percent (betamethasone dipropionate in a glycol formulation) and Dermovate ointment 0.05 percent (clobetasone propionate) and their effects on adrenal function were evaluated in two double-blind, parallel group studies. A fixed dose of 7 gm of ointment a day was applied topically

1984 Cutis; cutaneous medicine for the practitioner

4019. A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure. (PubMed)

A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure. Lateral internal sphincterotomy, the most common treatment for chronic anal fissure, may cause permanent injury to the anal sphincter, which can lead to fecal incontinence. We compared two nonsurgical treatments that avert the risk of fecal incontinence. We randomly assigned 50 adults with symptomatic chronic posterior anal fissures to receive treatment with either a total (...) of 20 U of botulinum toxin injected into the internal anal sphincter on each side of the anterior midline or 0.2 percent nitroglycerin ointment applied twice daily for six weeks.After two months, the fissures were healed in 24 of the 25 patients (96 percent) in the botulinum-toxin group and in 15 of the 25 (60 percent) in the nitroglycerin group (P=0.005). No patient in either group had fecal incontinence. At some time during treatment, five patients in the nitroglycerin group had transient

1999 NEJM

4020. [Results of a multicenter double-blind study in patients with resistant psoriasis and atopic dermatitis. Diprolene ointment vs. Dermovate ointment]. (PubMed)

Abstract Journal Article Randomized Controlled Trial Ergebnisse einer multizentrischen Doppelblindstudie bei Patienten mit resistenter Psoriasis und mit atopischer Dermatitis Diprolen-Salbe vs. Dermovate-Salbe. Switzerland Ther Umsch 0407224 0040-5930 0 Ointments 826Y60901U betamethasone-17,21-dipropionate 9842X06Q6M Betamethasone ADN79D536H Clobetasol IM Adolescent Adult Aged Betamethasone analogs & derivatives therapeutic use Clinical Trials as Topic Clobetasol analogs & derivatives therapeutic use (...) [Results of a multicenter double-blind study in patients with resistant psoriasis and atopic dermatitis. Diprolene ointment vs. Dermovate ointment]. 6379974 1984 09 12 2014 11 20 0040-5930 41 6 1984 Jun Therapeutische Umschau. Revue therapeutique Ther Umsch [Results of a multicenter double-blind study in patients with resistant psoriasis and atopic dermatitis. Diprolene ointment vs. Dermovate ointment]. 420-4 Blum G G Kröpfli P P Küng D D Suter H H ger Clinical Trial Comparative Study English

1984 Therapeutische Umschau. Revue therapeutique

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