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Topical Ointment

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3981. An evaluation of a 2% erythromycin ointment in the topical therapy of acne vulgaris. (Abstract)

An evaluation of a 2% erythromycin ointment in the topical therapy of acne vulgaris. Two hundred eight patients completed a 12-week, multicenter, double-blind, controlled study comparing a 2% erythromycin ointment to its vehicle. Patients were evaluated by inflammatory lesion counts and Cook acne severity grade at the initial visit and at weeks 2, 4, 8, 10, and 12. The 2% erythromycin ointment proved to be statistically more effective than the vehicle in reducing lesion counts and acne severity (...) grade at weeks 4, 8, 10, and 12. The ointment caused few side effects and was well tolerated by most patients.

1985 Journal of the American Academy of Dermatology

3982. Halogenation and topical corticosteroids: a comparison between the 17-butyrate esters of hydrocortisone and clobetasone in ointment bases. (Abstract)

Halogenation and topical corticosteroids: a comparison between the 17-butyrate esters of hydrocortisone and clobetasone in ointment bases. Clobetasone butyrate 0.05% (Eumovate), a halogenated topical steroid, was compared with hydrocortison butyrate 0.1% (Locoid) which does not contain any halogen atoms. In the treatment of eczema there was not difference between the preparations, but in that of psoriasis the halogen-containing steriod was significantly more effective. Under normal

1981 The British journal of dermatology Controlled trial quality: uncertain

3983. Short-term topical corticosteroid therapy (halcinonide ointment) in the management of atopic dermatitis. (Abstract)

Short-term topical corticosteroid therapy (halcinonide ointment) in the management of atopic dermatitis. The efficacy of short-term treatment of acute exacerbations of atopic dermatitis with a corticosteroid ointment (halcinonide, 0.1 percent) was demonstrated by comparing such a formulation with its ointment base (placebo). A double-blind, paired comparison study was conducted in 214 patients. Within two weeks the therapeutic response was judged excellent in 137 (64 percent) of the patients (...) receiving the corticosteroid treatment. The number of responses judged good to excellent was 182 (85 percent). With the placebo, there was an excellent response in 50 (23 percent) of the patients and the number judged good to excellent was 95 (44 percent). Although these placebo responses attested to the appropriateness of a highly occlusive ointment vehicle in this condition, the corticosteroid containing formulation was superior (p less than 0.001). In only 10 (5 percent) of the patients

1982 Cutis; cutaneous medicine for the practitioner Controlled trial quality: uncertain

3984. Once-daily treatment of psoriasis with topical glucocorticosteroid ointments. (Abstract)

Once-daily treatment of psoriasis with topical glucocorticosteroid ointments. A double-blind, vehicle-controlled comparison of two glucocorticosteroid ointments demonstrated that once-daily therapy for psoriasis was effective. After 3 weeks of once-daily therapy, psoriasis subjects treated with betamethasone dipropionate (BD) ointment or diflorasone diacetate (DD) ointment showed statistically significant (p less than 0.01) improvement compared to subjects using vehicle alone.

1983 Journal of the American Academy of Dermatology Controlled trial quality: uncertain

3985. The effect of topical fluocinonide ointment on phototherapy of psoriasis. (Abstract)

The effect of topical fluocinonide ointment on phototherapy of psoriasis. The effect of fluocinonide ointment and 5% crude coal tar on clearance of plaque-type psoriasis vulgaris by phototherapy was studied in 25 hospitalized patients using the bilateral comparison technique. All treated areas received ultraviolet radiation from Westinghouse fluorescent FS-40 bulbs (290-400 nm) in doses calculated to produce a minimal delayed erythema. The topically applied compounds (fluocinonide ointment, 5 (...) % Crude coal tar, white petrolatum) were applied individually or in combination. In nearly all comparisons clearance of psoriatic plaques was obtained after the same number of ultraviolet exposures, although many (8 or 14) of the areas treated with fluocinonide ointment had an accelerated early response. It thus appears that although the use of topical corticosteroids may enhance the early therapeutic response of psoriatic plaques it does not hasten the clearance of these plaques.

1982 The Journal of investigative dermatology Controlled trial quality: uncertain

3986. A double-blind study of topical massage with Rado-Salil ointment in mechanical low-back pain. (Abstract)

A double-blind study of topical massage with Rado-Salil ointment in mechanical low-back pain. Forty patients with acute mechanical low-back pain were treated in a double-blind manner with either Rado-Salil or placebo for 14 days. Statistically significant improvements in spontaneous pain, muscular contracture and in both the patient's and physician's opinions occurred by day 3. These improvements persisted at day 14 and, in addition, there were statistically significant improvements

1987 The Journal of international medical research Controlled trial quality: uncertain

3987. Topical nitroglycerin ointment in Raynaud's phenomenon. (Abstract)

Topical nitroglycerin ointment in Raynaud's phenomenon. The purpose of the study was to evaluate the hemodynamics of nitroglycerin ointment in Raynaud's phenomenon. 22 patients (15 women and 7 men aged 25-75 years) suffering from Raynaud's phenomenon were investigated in a double-blind paradigm. Blood flow measurements were performed by venous occlusion plethysmography. Cardiac output was registered by means of impedance cardiography. 800 mg nitroglycerin ointment 2% was applied on one hand (...) only. In the placebo group, finger blood flow, blood pressure, heart rate, and cardiac output did not change significantly. In the group receiving nitroglycerin, finger blood flow increased significantly from 21.6 +/- 6.0 to 31.7 +/- 7.0 ml/100 ml/min. Systolic blood pressure decreased from 126 +/- 4 to 118 +/- 3 mmHg. Cardiac output significantly decreased from 7.3 +/- 0.8 to 6.3 +/- 0.5 l/min. It is concluded that nitroglycerin ointment in Raynaud's phenomenon has a local and a systemic effect

1985 Zeitschrift für Kardiologie Controlled trial quality: uncertain

3988. Comparison of topical antibiotic ointments, a wound protectant, and antiseptics for the treatment of human blister wounds contaminated with Staphylococcus aureus. (Abstract)

Comparison of topical antibiotic ointments, a wound protectant, and antiseptics for the treatment of human blister wounds contaminated with Staphylococcus aureus. An open, randomized, human-model study was conducted to compare the effects of topical antibiotics, a wound protectant, and antiseptics on the rate of wound healing and bacterial growth using a modification of a method employing ammonium hydroxide-induced intradermal blisters inoculated with Staphylococcus aureus. Each volunteer (...) in the study had six blister wounds (three per forearm) to which a triple antibiotic (neomycin, polymyxin B, bacitracin) ointment or one of four other test agents was applied twice a day. A control wound remained untreated. All wounds were covered with an occlusive dressing after treatment. The time to healing (100 percent epithelialization) was evaluated for each wound. Wounds were cultured for bacterial growth after two treatments. Contaminated blister wounds treated with the triple antibiotic ointment

1987 Journal of Family Practice Controlled trial quality: uncertain

3989. Double-blind placebo-controlled study with topical 2% ketanserin ointment in the treatment of venous ulcers. (Abstract)

Double-blind placebo-controlled study with topical 2% ketanserin ointment in the treatment of venous ulcers. Previous animal and human data have shown that ketanserin, the first specific serotonin2 antagonist, may have beneficial effects on peripheral vascular diseases and on the healing of ulcers. In this double-blind study a 2% ketanserin ointment in a polyethylene glycol base was used to treat 23 patients with venous ulcers (13 ketanserin, 10 placebo). Classical wound care measures were (...) , ketanserin showed a response in 10 out of 11 patients as opposed to 5 out of 10 placebo patients at the end of the study. This first double-blind placebo-controlled study suggests that topically applied ketanserin promotes the healing of venous ulcers.

1989 Dermatologica

3990. Zinc chloride spray--magnesium hydroxide ointment dual topical regimen in the treatment of obstetric and gynecologic incisional wounds. (Abstract)

Zinc chloride spray--magnesium hydroxide ointment dual topical regimen in the treatment of obstetric and gynecologic incisional wounds. A randomized, double-blind, placebo-controlled study was conducted to determine the safety and efficacy of dual topical therapy with zinc chloride spray and magnesium hydroxide ointment in healing incisional wounds. The participants were 100 obstetric and gynecologic patients with abdominal and perineal incisional wounds; 85 completed the treatment regimen, 15 (...) healing time, a better control of infection, less dehiscence, and more effective pain control were observed in patients in the treatment group as compared with those in the placebo group. No side effects were noted in patients in either group. The dual topical therapy with zinc chloride spray and magnesium hydroxide ointment proved to be safe and effective in accelerating wound healing in obstetric and gynecologic patients.

1989 Clinical therapeutics Controlled trial quality: uncertain

3991. Topical 2% mupirocin versus 2% fusidic acid ointment in the treatment of primary and secondary skin infections. (Abstract)

Topical 2% mupirocin versus 2% fusidic acid ointment in the treatment of primary and secondary skin infections. The efficacy and side effects of topical mupirocin (Bactroban) and fusidic acid (Fucidin) ointment were compared in a double-blind, randomized trial in 70 patients who came to the Dermatologic Clinic of L'Enfant Jésus Hospital with primary or secondary (or both) skin infections. Thirty-five patients were treated with mupirocin and 35 patients were treated with fusidic acid three times (...) with fusidic acid, a clinical cure was achieved in 18 and improvement occurred in 15. Bacteriologic cure rates were 97% (30 of 31 patients evaluated) in the mupirocin-treated group, compared with 87% (27 of 31 patients evaluated) in the fusidic acid-treated group. No side effects were observed in either treatment group. Because topical 2% mupirocin has little or no potential for irritation, systemic side effects, or cross-resistance with other antibiotics, its efficacy is likely to make this new compound

1989 Journal of the American Academy of Dermatology Controlled trial quality: uncertain

3992. Evaluation of the safety and efficacy of topical nitroglycerin ointment to facilitate venous cannulation. (Abstract)

Evaluation of the safety and efficacy of topical nitroglycerin ointment to facilitate venous cannulation. The purpose of this study was to determine the safety and efficacy of 2% nitroglycerin ointment to facilitate venous cannulation. In a double-blind experimental design, 80 adult subjects were randomly assigned to receive a 2% nitroglycerin ointment or a placebo ointment prior to cannulation. Variables measured before and after ointment application included heart rate, electrocardiogram (...) , vein size, and presence of headache. No statistically significant differences were found in vein size or adverse effects following nitroglycerin ointment application.

1994 Nursing research Controlled trial quality: uncertain

3993. [Clinical comparison of two topical antiviral ointments in herpes]. (Abstract)

[Clinical comparison of two topical antiviral ointments in herpes]. Herpetic skin lesions have importance and growing frequency in the population. The authors report a double blind study involving 51 patients suffering from recurrent labial herpes to compare the effectiveness and adverse reactions of two topical antiviral preparations, the aciclovir (Zovirax) and epervudine (Hevizos). There was no significant difference between the two treatment groups in the healing tendency of herpetic (...) lesions. The rate of relapses in a two months period was 44.4% in the group treated with aciclovir and 20.8% in the group treated with epervudine, the difference is not significant. Both preparation was well tolerated, only itching occurred as adverse reaction in the group treated with aciclovir. According to the results of the study the original Hungarian product (Hevizos), is at least as effective as the other topical preparation.

1995 Orvosi hetilap Controlled trial quality: uncertain

3994. The use of topical 5% lignocaine ointment for the relief of pain associated with post-operative nasal packing. (Abstract)

The use of topical 5% lignocaine ointment for the relief of pain associated with post-operative nasal packing. Packing of the nasal cavity remains a common routine precautionary measure following septal surgery. The nasal pack and its removal 24 h later are often cited by patients as the most painful aspects of septal surgery. We present the results of a randomized, prospective controlled trial of the use of topical 5% lignocaine ointment as a method of pain relief following post-operative (...) nasal packing. Post-operative pain as measured using a visual analogue scale at 3 h post-operatively was halved in patients receiving a lignocaine impregnated nasal pack compared with those having a standard vaseline gauze pack (P < 0.05). Pain scores at 6 h post-operatively and at pack removal were also reduced, but these failed to reach significance. No patients suffered reactionary haemorrhage. The use of topical lignocaine ointment is safe and may have a place in the relief of pain due to post

1995 Clinical otolaryngology and allied sciences Controlled trial quality: uncertain

3995. Topical ointment therapy benefits premature infants. (Abstract)

Topical ointment therapy benefits premature infants. Premature infants have an ineffective epidermal barrier. The aim of this study was to investigate the cutaneous and systemic effects of preservative-free topical ointment therapy in premature infants.We conducted a prospective, randomized study of 60 infants less than 33 weeks' estimated gestational age. The treated infants received therapy for 2 weeks with twice-daily preservative-free topical ointment therapy while the control group (...) received no topical treatment or as-needed therapy with a water-in-oil emollient. Data collection included transepidermal water loss (TEWL) measurement, skin condition evaluations, fungal and quantitative bacterial skin cultures, analysis of fluid requirements, patterns of weight low or gain, and the incidence of blood and cerebrospinal fluid cultures positive for microorganisms.We found that topical ointment therapy significantly decreased TEWL during the first 6 hours after the initial application

1996 The Journal of pediatrics Controlled trial quality: uncertain

3996. Treatment of onychomycosis: a randomized, double-blind comparison study with topical bifonazole-urea ointment alone and in combination with short-duration oral griseofulvin. (Abstract)

Treatment of onychomycosis: a randomized, double-blind comparison study with topical bifonazole-urea ointment alone and in combination with short-duration oral griseofulvin. A parallel-group double-blind study was carried out which compared the efficacy of chemical avulsion of affected nail by urea 40% and bifonazole 1% cream alone with that of the same local therapy combined with short-term oral griseofulvin in onychomycosis. A total of 120 patients were included in the study. Patients (...) ' characteristics were comparable in both treatment groups. Of the 98 patients fully evaluated, 91 had toenail involvement and only seven had fingernail involvement. Forty-six of the patients were men and 51 were women. The mean age of the patients was 47.14 +/- 13.84 years (range 17-80 years). The duration of onychomycosis was for more than 1 year in 96 patients and for 3 months duration in only one patient, who was in the placebo group. Forty patients had received different previous therapies. All topical

1997 International journal of dermatology Controlled trial quality: uncertain

3997. Comparative atrophogenicity potential of medium and highly potent topical glucocorticoids in cream and ointment according to ultrasound analysis. (Abstract)

Comparative atrophogenicity potential of medium and highly potent topical glucocorticoids in cream and ointment according to ultrasound analysis. 24 healthy volunteers with no history of skin disease were entered in a 6-week double-blind randomized study to compare the atrophogenicity potentials of both cream and ointment forms of triamcinolone acetonide and clobetasol propionate. The atrophogenicity potential of cream preparations turned out to be greater than that of ointment preparations

1992 Skin pharmacology : the official journal of the Skin Pharmacology Society Controlled trial quality: uncertain

3998. Topical lithium succinate ointment (Efalith) in the treatment of AIDS-related seborrhoeic dermatitis. (Abstract)

Topical lithium succinate ointment (Efalith) in the treatment of AIDS-related seborrhoeic dermatitis. A randomised, double-blind, placebo-controlled trial with lithium succinate ointment was conducted in patients with AIDS-associated facial seborrhoeic dermatitis. Twice daily applications of the ointment brought about a rapid (2.5 days) and highly significant (P = 0.007) improvement in the severity of the condition. Lithium succinate ointment is well tolerated and can be a useful treatment

1997 Clinical and experimental dermatology Controlled trial quality: uncertain

3999. Comparison of foscarnet cream, acyclovir cream, and acyclovir ointment in the topical treatment of experimental cutaneous herpes simplex virus type 1 infection. Full Text available with Trip Pro

Comparison of foscarnet cream, acyclovir cream, and acyclovir ointment in the topical treatment of experimental cutaneous herpes simplex virus type 1 infection. Topical foscarnet (PFA) and acyclovir (ACV) were compared in the dorsal cutaneous guinea pig model of herpes simplex virus type 1 infection. The relative order of efficacy was PFA cream greater than ACV cream greater than ACV ointment. In vitro studies demonstrated that PFA and ACV formulated in cream vehicles penetrated through guinea (...) pig skin 7- to 10-fold faster than did ACV in ointment.

1986 Antimicrobial Agents and Chemotherapy

4000. Failure of topical acyclovir in ointment to penetrate human skin. Full Text available with Trip Pro

Failure of topical acyclovir in ointment to penetrate human skin. Topical acyclovir (ACV) in polyethylene glycol (PEG) ointment has been disappointing in the treatment of recurrent herpes simplex virus infections in immunocompetent patients. To investigate the possible role of poor drug delivery from this formulation, we studied the penetration of ACV through excised human skin from three vehicles; PEG ointment, modified aqueous cream, and dimethyl sulfoxide. A second antiviral agent (...) . The poor clinical results seen with topical use of ACV ointment may be due in part to retarded drug delivery from this formulation.

1986 Antimicrobial Agents and Chemotherapy

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