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Topical Ointment

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21. Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma: A Randomized Clinical Trial Full Text available with Trip Pro

Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma: A Randomized Clinical Trial 28793140 2019 01 28 2019 01 28 2168-6084 153 10 2017 10 01 JAMA dermatology JAMA Dermatol Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma: A Randomized Clinical Trial. 1061-1063 10.1001/jamadermatol.2017.2529 Kessels Janneke J Department of Dermatology, Maastricht University Medical Center, Maastricht, the Netherlands. GROW School for Developmental Biology (...) . Kelleners-Smeets Nicole W J NWJ Department of Dermatology, Maastricht University Medical Center, Maastricht, the Netherlands. GROW School for Developmental Biology and Oncology, Maastricht University, Maastricht, the Netherlands. eng Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't United States JAMA Dermatol 101589530 2168-6068 0 Ointments 0 green tea extract polyphenone E 8R1V1STN48 Catechin AIM IM Administration, Topical Biopsy Camellia sinensis Carcinoma, Basal Cell

2017 JAMA dermatology Controlled trial quality: predicted high

22. Successful Management of Zoon’s Balanitis with Topical Mupirocin Ointment: A Case Report and Literature Review of Mupirocin-Responsive Balanitis Circumscripta Plasmacelluaris Full Text available with Trip Pro

Successful Management of Zoon’s Balanitis with Topical Mupirocin Ointment: A Case Report and Literature Review of Mupirocin-Responsive Balanitis Circumscripta Plasmacelluaris Zoon's balanitis, also referred to as balanitis circumscripta plasmacellularis (BCP), is an idiopathic, benign inflammatory condition of the glans penis and foreskin most often seen in elderly uncircumcised men. A patient with a biopsy-confirmed diagnosis of BCP who was successfully treated with topical mupirocin (...) ointment is described.The PubMed database was searched with the key words: bactroban, balanitis, cell, circumscripta, mupirocin, plasma, plasmacellularis, tacrolimus, Zoon. The papers generated by the search and their references were reviewed.Treatments for BCP have previously included circumcision and topical calcineurin inhibitors. Our patient with BCP rapidly resolved after initiating treatment with mupirocin 2% ointment.BCP is a benign dermatosis affecting the glans penis and foreskin. We confirm

2017 Dermatology and therapy

23. Topical Sirolimus Ointment for Cutaneous Angiofibromas in Subjects With Tuberous Sclerosis Complex

Topical Sirolimus Ointment for Cutaneous Angiofibromas in Subjects With Tuberous Sclerosis Complex Topical Sirolimus Ointment for Cutaneous Angiofibromas in Subjects With Tuberous Sclerosis Complex - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. Topical Sirolimus Ointment for Cutaneous Angiofibromas in Subjects With Tuberous Sclerosis Complex The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03363763 Recruitment Status

2017 Clinical Trials

24. Study of RVT-501 Topical Ointment in Pediatric Patients With Atopic Dermatitis

Study of RVT-501 Topical Ointment in Pediatric Patients With Atopic Dermatitis Study of RVT-501 Topical Ointment in Pediatric Patients With Atopic Dermatitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Study of RVT-501 Topical Ointment in Pediatric Patients With Atopic Dermatitis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03394677 Recruitment Status : Completed First Posted : January 9, 2018 Last Update Posted : July 19, 2018 Sponsor: Dermavant Sciences GmbH Information provided

2017 Clinical Trials

25. Reduction of postoperative pain and improvement of patients' comfort after Milligan-Morgan hemorrhoidectomy using topical application of vitamin E ointment. (Abstract)

Reduction of postoperative pain and improvement of patients' comfort after Milligan-Morgan hemorrhoidectomy using topical application of vitamin E ointment. 26715437 2017 04 03 2017 04 03 1432-1262 31 7 2016 Jul International journal of colorectal disease Int J Colorectal Dis Reduction of postoperative pain and improvement of patients' comfort after Milligan-Morgan hemorrhoidectomy using topical application of vitamin E ointment. 1371-2 10.1007/s00384-015-2483-4 Ruiz-Tovar Jaime J Department (...) Montiel M Department of Surgery, Coloproctology Unit, University Hospital King Juan Carlos, Gladiolo, s/n, 28933, Mostoles, Madrid, Spain. Garia-Olmo Damian D Department of Surgery, Coloproctology Unit, University Hospital King Juan Carlos, Gladiolo, s/n, 28933, Mostoles, Madrid, Spain. eng Letter Randomized Controlled Trial 2015 12 29 Germany Int J Colorectal Dis 8607899 0179-1958 1406-18-4 Vitamin E IM Administration, Topical Adult Aged Female Hemorrhoidectomy adverse effects Humans Length of Stay

2017 International journal of colorectal disease Controlled trial quality: uncertain

26. Safety and Efficacy of Diacerein 1% Ointment Topical Formulation Compared to Placebo for Subjects With Epidermolysis Bullosa Simplex (EBS)

Safety and Efficacy of Diacerein 1% Ointment Topical Formulation Compared to Placebo for Subjects With Epidermolysis Bullosa Simplex (EBS) Safety and Efficacy of Diacerein 1% Ointment Topical Formulation Compared to Placebo for Subjects With Epidermolysis Bullosa Simplex (EBS) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study (...) Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Safety and Efficacy of Diacerein 1% Ointment Topical Formulation Compared to Placebo for Subjects With Epidermolysis Bullosa Simplex (EBS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov

2017 Clinical Trials

27. Study of Topical SOR007 Ointment for Cutaneous Metastases

Study of Topical SOR007 Ointment for Cutaneous Metastases Study of Topical SOR007 Ointment for Cutaneous Metastases - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Study of Topical SOR007 Ointment (...) Biotest, Inc. Information provided by (Responsible Party): NanOlogy, LLC Study Details Study Description Go to Brief Summary: This study evaluates a topical nanoparticle paclitaxel ointment (SOR007) for the treatment of cutaneous metastases from non-melanoma cancer in adults. Three concentrations of SOR007 will be evaluated in dose-rising cohorts of three. An expanded cohort will treat additional subjects at the maximum tolerated dose. Condition or disease Intervention/treatment Phase Cutaneous

2017 Clinical Trials

28. The topical application of low-temperature argon plasma enhances the anti-inflammatory effect of Jaun-ointment on DNCB-induced NC/Nga mice. Full Text available with Trip Pro

The topical application of low-temperature argon plasma enhances the anti-inflammatory effect of Jaun-ointment on DNCB-induced NC/Nga mice. Jaun-ointment (JO), also known as Shiunko in Japan, is one of the most popular medicinal formulae used in Korean traditional medicine for the external treatment of skin wound and inflammatory skin conditions. Since JO is composed of crude mixture of two herbal extracts (radix of Lithospermum erythrorhizon Siebold & Zucc and Angelica gigas Nakai), those been (...) proved its anti-inflammatory activities in-vitro and in-vivo, JO has been expected as a good alternative treatment option for atopic dermatitis (AD). However, due to the lack of strategies for the penetrating methods of JO's various anti-inflammatory elements into the skin, an effective and safe transdermal drug delivery system needs to be determined. Here, low-temperature argon plasma (LTAP) was adopted as an ancillary partner of topically applied JO in a mice model of AD and the effectiveness

2017 BMC Complementary and Alternative Medicine

29. External genital and perianal warts: green tea (Camellia sinensis) leaf extract 10% ointment

summaries of product characteristics (SPCs), British national formulary (BNF) or the MHRA or NICE websites for up-to-date information. Summary Green tea (Camellia sinensis) leaf extract 10% ointment (Catephen) is a self-administered topical treatment for external genital and perianal warts. In 2 randomised controlled trials (RCTs) involving a total of 1005 adults, green tea leaf extract 10% ointment was 2-fold more effective than vehicle (placebo) ointment in terms of complete clearance of all baseline (...) with the person. There are 3 self-administered topical treatment options for external genital and perianal warts. All can cause local skin reactions. The maximum treatment duration for green tea leaf extract ointment is 16 weeks, with application 3 times a day. The maximum duration ranges from 4 to 5 weeks for podophyllotoxin preparations to 16 weeks for imiquimod 5% cream. These treatments require less frequent administration than green tea leaf extract ointment. These 3 treatments are available in a variety

2015 National Institute for Health and Clinical Excellence - Advice

30. Topical Ointment

Topical Ointment Topical Ointment Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Topical Ointment Topical Ointment Aka: Topical (...) ) May occlude s more than less occlusive (such as s) VI. Pharmacology ointments are more potent than creams Ointment vehicle holds steroid to skin surface Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Topical Ointment." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Pharmacology About FPnotebook.com is a rapid access, point-of-care

2018 FP Notebook

31. Comparison of Lindioil (Indigo Naturalis Oil Extract) Ointment to Protopic® Ointment 0.1% in Treating Atopic Dermatitis

by itchiness. Topical corticosteroids are typically used to treat AD. However, many patients have concerns about the safety of long-term use, and seek alternative therapies such as traditional Chinese medicine (TCM). In TCM, indigo naturalis has been used to treat various infectious and inflammatory skin diseases for hundreds of years. The investigate also found that the results of indigo naturalis ointment treatment in other trial were comparable to the results of calcineurin inhibitor (such as Tacrolimus (...) of Lindioil (Indigo Naturalis Oil Extract) Ointment to Protopic® (Tacrolimus 0.1%) Ointment in Treating Atopic Dermatitis: A Randomized, Evaluator-blind, Crossover, Active-Controlled Trial Estimated Study Start Date : April 1, 2019 Estimated Primary Completion Date : July 31, 2021 Estimated Study Completion Date : July 31, 2021 Resource links provided by the National Library of Medicine related topics: related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental

2018 Clinical Trials

32. Study To Assess Local Tolerability of Crisaborole 2% Ointment and Vehicle Ointment In Healthy Participants Using Subject-reported Assessments and Objective Measurements

applied to sensitive skin locations on left side of body Drug: Within-Subject Active vs Placebo Topical Applications Crisaborole 2% ointment (right side) and Placebo vehicle ointment (left side) Group B (Crisaborole LEFT SIDE / Vehicle RIGHT SIDE) Crisaborole placebo vehicle ointment applied to 7 sensitive skin sites on right side of body. Crisaborole ointment 2% applied to 7 sensitive skin locations on left side of body Drug: Within-Subject Active vs. Placebo Topical Applications Crisaborole 2 (...) Study To Assess Local Tolerability of Crisaborole 2% Ointment and Vehicle Ointment In Healthy Participants Using Subject-reported Assessments and Objective Measurements Study To Assess Local Tolerability of Crisaborole 2% Ointment and Vehicle Ointment In Healthy Participants Using Subject-reported Assessments and Objective Measurements - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search

2018 Clinical Trials

33. Phase 2 clinical study of delgocitinib ointment in pediatric patients with atopic dermatitis Full Text available with Trip Pro

Phase 2 clinical study of delgocitinib ointment in pediatric patients with atopic dermatitis Topical delgocitinib (JTE-052), a novel Janus kinase inhibitor, had been shown to be clinically effective in adults with atopic dermatitis (AD). However, the efficacy of topical delgocitinib in pediatric patients with AD remained unclear.We sought to evaluate the efficacy and safety of delgocitinib ointment in pediatric patients with AD.In this phase 2 clinical study (JapicCTI-173553) Japanese patients (...) aged 2 through 15 years with AD were randomized in a 1:1:1 ratio to receive 0.25% or 0.5% delgocitinib ointment or vehicle ointment twice daily for 4 weeks. The primary efficacy end point was the percentage change from baseline in the modified Eczema Area and Severity Index score at the end of treatment (EOT).At EOT, modified Eczema Area and Severity Index scores in both delgocitinib groups were significantly reduced compared with that in the vehicle group. The least-squares mean percentage change

2019 EvidenceUpdates

34. Are Topical Nonsteroidal Anti-Inflammatory Drugs Useful for Analgesia in Patients With Traumatic Corneal Abrasions? Full Text available with Trip Pro

, the frequency of healing at 24 and 48 hours after injury, whether the use of concurrent topical antibiotics (drops or ointments) with additional lubricating effects reduced pain, and the complications of corneal abrasions through the use of topical nonsteroidal anti-inflammatory drugs versus the control groups. Data Extraction and Synthesis Two reviewers independently assessed the articles for eligibility, performed data extraction, assessed risk of bias by the Cochrane Risk of Bias Tool, x 1 Higgins, J.P (...) ointment versus topical polyvinyl alcohol and an ophthalmic antibiotic ointment, x 9 Brahma, A.K., Shah, S., Hillier, V.F. et al. Topical analgesia for superficial corneal injuries. J Accid Emerg Med . 1996 ; 13 : 186–188 | | a topical nonsteroidal anti-inflammatory drug versus topical polyvinyl alcohol, x 10 Goyal, R., Shankar, J., Fone, D.L. et al. Randomised controlled trial of ketorolac in the management of corneal abrasions. Acta Ophthalmol Scand . 2001 ; 79 : 177–179 | | | and a topical

2019 Annals of Emergency Medicine Systematic Review Snapshots

35. Topical Photodynamic therapy

Topical Photodynamic therapy EDF Guidelines Office to Professor Dr. Nast: Martin Dittmann, Klinik für Dermatologie, Venerologie und Allergologie, Campus Charité Mitte, Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany phone: +49 30 450 618 313, fax: +49 30 450 518 977, e-mail: martin.dittmann@charite.de European Dermatology Forum Guidelines on Topical Photodynamic Therapy Updated version – 2019 Expiry date: 08/2022 European Dermatology Forum Guidelines on Topical (...) that readers could perceive to have influenced, or that give the appearance of potentially influencing, what you wrote in the submitted work? No Disclaimer These updated guidelines consider all current and emerging indications for the use of topical photodynamic therapy (PDT) in Dermatology. In addition to undertaking an updated systematic literature review, they include evidence reviewed in previous therapy specific PDT guidelines published in 2007 1 , 2013 2,3 ,and 2018 4 as well as disease-specific

2019 European Dermatology Forum

36. Contact Dermatitis after Prescription of an Ophthalmic Ointment Containing Fradiomycin Sulfate: A Retrospective Database Study Using Japanese Health Insurance Claims Data Full Text available with Trip Pro

Contact Dermatitis after Prescription of an Ophthalmic Ointment Containing Fradiomycin Sulfate: A Retrospective Database Study Using Japanese Health Insurance Claims Data Topical ointments containing fradiomycin sulfate, such as fradiomycin sulfate/methylprednisolone (F/M) and fradiomycin sulfate/betamethasone sodium phosphate (F/B), are known to cause allergic contact dermatitis (CD) in some patients, especially when used for the periocular region. F/M is commonly prescribed to patients (...) that there was no clear difference in the incidence of CD after filling prescriptions for F/M, F/B, and ophthalmic ointment containing a steroid, while the incidence with antibiotics was lower by 0.03-0.04 compared with the other groups. Considering the observation that the investigational drugs were repeatedly prescribed even after the diagnosis of CD, it is critical that the risk of CD with these prescribed topical ointments is better understood by primary care physicians in order to take appropriate

2017 Drugs - real world outcomes

37. Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients Full Text available with Trip Pro

day, after the delivery of radiation. Skin reaction was recorded and compared between the two halves of the breast. Vitamin D was well tolerated by patients with no local or systemic allergic reactions. Radiation dermatitis was not significantly different between both treatment arms. Topical vitamin D ointment is not superior to Aqua cream for prevention of radiation-induced dermatitis in women treated with adjuvant radiation for breast cancer. (...) Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients Radiation dermatitis occurs frequently during adjuvant radiation therapy for breast cancer. Prevention of radiation dermatitis by applying various creams and ointments has a limited success, and Aqua cream which has urea as one of its active ingredients is used in many institutions as a preventive treatment. The primary goal of this study is to assess the effect of vitamin D (calcipotriol) ointment in prevention

2017 NPJ breast cancer Controlled trial quality: uncertain

38. Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults. Full Text available with Trip Pro

Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults. Additional topical treatments for atopic dermatitis (AD) are needed that provide relief while minimizing risks.We sought to assess the efficacy and safety of crisaborole ointment, a phosphodiesterase 4 inhibitor, in two phase III AD studies (AD-301: NCT02118766; AD-302: NCT02118792).Two identically designed, vehicle

2016 Journal of American Academy of Dermatology Controlled trial quality: predicted high

39. Ultrastructural Analysis of the Foreskin in Patients with True Phimosis Treated or Not- Treated with Topic Betamethasone and Hyaluronidase Ointment. (Abstract)

Ultrastructural Analysis of the Foreskin in Patients with True Phimosis Treated or Not- Treated with Topic Betamethasone and Hyaluronidase Ointment. To evaluate, by using scanning electron microscopy (SEM), the possible alterations of the foreskin connective tissue in patients with true phimosis submitted to topical treatment with betamethasone and hyaluronidase ointment.We studied 15 patients (mean 5.3 years old) submitted or not to topical application of betamethasone 0.2% and hyaluronidase (...) not agree with the clinical treatment and opted for circumcision directly. These patients served as the control group (nontreated). Eight patients submitted to topical treatment could not expose the glans and were referred for circumcision. In SEM, with a magnification of 5000×, we observed important differences in the organization of the collagen and elastic system fibers when comparing treated and nontreated patients with betamethasone and hyaluronidase. Treated patients presented a different

2016 Urology

40. Crisaborole Topical Ointment, 2% in Patients Ages 2 to 17 Years with Atopic Dermatitis: A Phase 1b, Open‐Label, Maximal‐Use Systemic Exposure Study Full Text available with Trip Pro

Crisaborole Topical Ointment, 2% in Patients Ages 2 to 17 Years with Atopic Dermatitis: A Phase 1b, Open‐Label, Maximal‐Use Systemic Exposure Study Phosphodiesterase-4 (PDE4) is a promising target in atopic dermatitis (AD) treatment. The pharmacokinetics (PK), safety, and efficacy of crisaborole topical ointment, 2% (formerly AN2728) (Anacor Pharmaceuticals, Palo Alto, CA), a boron-based benzoxaborole PDE4 inhibitor, were evaluated in children with mild to moderate AD.This phase 1b, open (...) -label, maximal-use study of crisaborole topical ointment, 2% applied twice daily (dose 3 mg/cm(2) ) for 28 days enrolled patients ages 2 to 17 years with extensive AD involving 25% or more or 35% or more treatable body surface area, depending on age. Primary PK and safety assessments included systemic exposure to crisaborole and its metabolites after 7 days of treatment and the incidence of treatment-emergent adverse events (TEAEs). Secondary efficacy assessments included change from baseline

2016 Pediatric dermatology

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