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Topical Ointment

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3941. Usefulness of lanoconazole (Astat) cream in the treatment of hyperkeratotic type tinea pedis. Comparative study of monotherapy and combination therapy with 10% urea ointment (Pastaron). (Abstract)

Usefulness of lanoconazole (Astat) cream in the treatment of hyperkeratotic type tinea pedis. Comparative study of monotherapy and combination therapy with 10% urea ointment (Pastaron). Hyperkeratotic type tinea pedis is a refractory type of superficial dermatomycosis. Treatment for hyperkeratotic type tinea pedis is mainly with oral antimycotics, such as griseofulvin, and healing is generally considered to be difficult with only topical antimycotics. In this randomized comparative study (...) , the usefulness of a topical application of 1% lanoconazole cream (Astat) monotherapy (group I) was compared with that of combination therapy with 1% lanoconazole cream and 10% urea ointment (Pastaron) (group II) in a series of patients with hyperkeratotic type tinea pedis. The clinical improvement rates (percentage of 'marked improvement' plus 'moderate improvement') was 70.0% in group I and 95.7% in group II. The fungal eradication rate was 5.0% in group I and 43.5% in group II after 4 weeks of treatment

2001 Mycoses Controlled trial quality: uncertain

3942. A prospective randomized trial of diltiazem and glyceryltrinitrate ointment in the treatment of chronic anal fissure. (Abstract)

A prospective randomized trial of diltiazem and glyceryltrinitrate ointment in the treatment of chronic anal fissure. The aim of this study was to compare prospectively diltiazem with GTN ointment in the treatment of anal fissure.Of 43 outpatients with chronic anal fissure, 22 patients were randomized to topical diltiazem (2%) ointment and 21 patients to glyceryltrinitrate (GTN) (0.5%) ointment twice daily for 8 weeks. During the course of treatment each patient was seen three times. Side (...) -effects and healing were recorded.Healing occurred in 19 of 22 patients treated with diltiazem and 18 of 21 patients were cured with GTN (P = 0.95). Those who were treated with nitroglycerin ointment developed headache and dizziness developed after GTN in 33.3% of cases while no patient had any side-effects after diltiazem.Diltiazem and glyceryltrinitrate (GTN) were equally effective in healing anal fissure but the former resulted in fewer side-effects.

2003 Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland Controlled trial quality: uncertain

3943. Can nitroglycerine ointment facilitate newborn heelstick blood collection? A randomized controlled trial. Full Text available with Trip Pro

Can nitroglycerine ointment facilitate newborn heelstick blood collection? A randomized controlled trial. Newborn heelstick blood collection can be a painful procedure in part because of the time required to obtain sufficient quantity of blood. No previous studies have determined whether local vasodilatation using topical nitroglycerine ointment (NGO) would facilitate heelstick blood collection.To determine if the topical application of NGO would reduce the time needed to collect the required (...) amount of blood for newborn metabolic screening and, in turn, reduce the pain/distress of the procedure.In a randomized, prospective, placebo controlled and blinded fashion, term newborns in a well nursery received either topical nitroglycerine or placebo ointment 10 minutes prior to heelstick. Total time and number of heelsticks required to complete the collection were measured along with crying time, heart rate and blood pressure.In all, 50 were studied, 25 in each group. There was no statistical

2003 Journal of perinatology : official journal of the California Perinatal Association Controlled trial quality: uncertain

3944. Calcitriol ointment and clobetasol propionate cream: a new regimen for the treatment of plaque psoriasis. (Abstract)

Calcitriol ointment and clobetasol propionate cream: a new regimen for the treatment of plaque psoriasis. For psoriasis therapy, topical derivatives of vitamin D3 represent a versatile option: they can be used either alone or in combination with other agents such as topical corticosteroids. In this two-phase parallel-group study, the naturally occurring vitamin D3 analogue, calcitriol, was compared with the vitamin D analogue calcipotriol in 125 patients with chronic plaque-type psoriasis (...) . The proposed treatment regimen was an initial bitherapy for 2 or 4 weeks, with clobetasol propionate 0.05% cream, a super potent topical corticosteroid applied in the morning and either calcitriol 3 mug/g ointment or calcipotriol 50 mug/g ointment applied in the evening, followed by monotherapy with either calcitriol or calcipotriol applied twice daily until endpoint week 12. Efficacy evaluations (global assessment of improvement, PASI and body surface area (BSA) affected) showed no significant differences

2003 European journal of dermatology : EJD Controlled trial quality: uncertain

3945. Flow cytometric assessment of clearance and relapse characteristics in psoriasis vulgaris after treatment with weekly clobetasol lotion under hydrocolloid occlusion versus twice-daily clobetasol ointment. (Abstract)

Flow cytometric assessment of clearance and relapse characteristics in psoriasis vulgaris after treatment with weekly clobetasol lotion under hydrocolloid occlusion versus twice-daily clobetasol ointment. Clearance and relapse characteristics of clobetasol lotion under hydrocolloid occlusion once weekly versus clobetasol ointment twice daily were assessed in a comparative flow cytometric study. Quantitative analysis of markers for epidermal proliferation, differentiation and inflammation (...) possible that the outcome in the treatment of more extensive psoriatic lesions might be different, the present study suggests that the robust clinical efficacy of the treatment with a topical corticosteroid under hydrocolloid occlusion is not associated with a rebound phenomenon.Copyright 2002 S. Karger AG, Basel

2002 Skin pharmacology and applied skin physiology Controlled trial quality: uncertain

3946. Tacrolimus ointment 0.1% in the treatment of nickel-induced allergic contact dermatitis. (Abstract)

allergic contact dermatitis, a T(H)1-mediated disease.This was a double-blind, randomized, vehicle-controlled, bilateral paired comparison study to assess the safety and efficacy of topical tacrolimus (Protopic, Fujisawa Healthcare Inc, Deerfield, Ill) ointment 0.1% in the treatment of allergic contact dermatitis induced by nickel sulfate. Volunteers were individuals with known hypersensitivity to nickel. Reactivity to nickel was graded both as the investigator's global assessment and total signs (...) Tacrolimus ointment 0.1% in the treatment of nickel-induced allergic contact dermatitis. Tacrolimus is a macrolactam that prevents the transcription of messenger RNA for various inflammatory cytokines in both helper T cells (types 1 and 2) (T(H)1 and T(H)2). It is currently approved for the treatment of moderate to severe atopic dermatitis, a Th2-mediated disease, in children and adults.We sought to evaluate the safety and efficacy of tacrolimus ointment 0.1% in the treatment of nickel-induced

2003 Journal of the American Academy of Dermatology Controlled trial quality: uncertain

3947. Clocortolone pivalate cream 0.1% used concomitantly with tacrolimus ointment 0.1% in atopic dermatitis. (Abstract)

Clocortolone pivalate cream 0.1% used concomitantly with tacrolimus ointment 0.1% in atopic dermatitis. This study was designed to evaluate the safety and efficacy of concomitant therapy with the corticosteroid clocortolone pivalate cream 0.1% (Cloderm Cream 0.1%) and the topical immunosuppressive agent tacrolimus ointment 0.1% (Protopic Ointment 0.1%) and to compare each drug alone for the treatment of atopic dermatitis in adolescents and adults. Concomitant therapy may minimize the potential (...) adverse effects of both treatments taken alone and may potentially improve overall response. In this 21-day study with 57 patients with atopic dermatitis, groups of 19 patients were randomized to 1 of 3 treatments: concomitant treatment with clocortolone pivalate cream 0.1% and tacrolimus ointment 0.1% (CPC+ TO), monotherapy with clocortolone pivalate cream 0.1% (CPC), or monotherapy with tacrolimus ointment 0.1% (TO). CPC+ TO was statistically superior to TO alone in the percentage change

2003 Cutis; cutaneous medicine for the practitioner Controlled trial quality: uncertain

3948. Pain control in a randomized, controlled, clinical trial comparing moist exposed burn ointment and conventional methods in patients with partial-thickness burns. Full Text available with Trip Pro

Pain control in a randomized, controlled, clinical trial comparing moist exposed burn ointment and conventional methods in patients with partial-thickness burns. Conventional management of partial-thickness burn wounds includes the use of paraffin gauze dressing, frequently with topical silver-based antibacterial creams. Some creams form an overlying slough that renders wound assessment difficult and are painful upon application. An alternative to conventional management, moist exposed burn (...) ointment (MEBO), has been proposed as a topical agent that may accelerate wound healing and have antibacterial and analgesic properties. One hundred fifteen patients with partial-thickness burns were randomly assigned to conventional (n = 58) or MEBO treatment (n = 57). A verbal numerical rating score of pain was made in the morning, after burn dressing, and some 8 hours later. Patient pain profiles were summarized by locally weighted regression smoothing technique curves and the difference between

2003 Journal of Burn Care & Rehabilitation Controlled trial quality: uncertain

3949. A study to compare the use of fusidic acid viscous eye drops and chloramphenicol eye ointment in an accident and emergency department. Full Text available with Trip Pro

A study to compare the use of fusidic acid viscous eye drops and chloramphenicol eye ointment in an accident and emergency department. A total of 300 patients attending an Accident and Emergency department with ophthalmic complaints needing topical antibiotic treatment were treated with fucithalmic or chloramphenicol (chloromycetin). Their compliance and the incidence of side effects were assessed. There was a 70.3% response rate to the questionnaire. Of the patients 51.3% using fucithalmic

1991 Archives of Emergency Medicine

3950. Lignocaine ointment and local anaesthesia in preterm infants. Full Text available with Trip Pro

Lignocaine ointment and local anaesthesia in preterm infants. The ability of topically applied lignocaine ointment to produce surface anaesthesia was examined in 45 preterm infants (gestational age 25 to 35 weeks) at a median age of 2 days. Two strengths of ointment, 5% and 30%, were tested at 30 and 60 minutes after application to the dorsum of the foot. Anaesthesia was assessed by comparing the response to skin stimulation at the test and control sites, using von Frey hairs. In 84% of cases (...) responses indicated that there was no surface anaesthesia. Topically applied lignocaine ointment is not an effective local anaesthetic in preterm infants, presumably due to poor absorption.

1995 Archives of Disease in Childhood. Fetal and Neonatal Edition

3951. Value of charcoal media for recovering staphylococci incorporated in mupirocin ointment. Full Text available with Trip Pro

Value of charcoal media for recovering staphylococci incorporated in mupirocin ointment. The use of charcoal blood agar supported a good recovery of staphylococci incorporated in Mupirocin ointment in a test in vitro system. The efficacy of this medium was particularly emphasised in the recovery of staphylococci damaged by six hours' exposure to Mupirocin. The media will be of value in following the progress of staphylococcal carriage or infection in patients or carriers being treated (...) with topical Mupirocin.

1987 Journal of Clinical Pathology

3952. Towards evidence based emergency medicine: best BETs from Manchester Royal Infirmary. Routine use of antibiotic ointment and wound healing. Full Text available with Trip Pro

Towards evidence based emergency medicine: best BETs from Manchester Royal Infirmary. Routine use of antibiotic ointment and wound healing. A short cut review was carried out to establish whether topical antibiotics improved the outcome of simple wounds. Altogether 71 papers were found using the reported search, of which one presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results

2002 Emergency Medicine Journal

3953. Treatment of toxic epidermal necrolysis with moisture-retentive ointment: a case report and review of the literature. (Abstract)

Treatment of toxic epidermal necrolysis with moisture-retentive ointment: a case report and review of the literature. Toxic epidermal necrolysis (TEN) is a rare condition that was described by Lyell in 1956. It is a severe, acute, adverse, primarily drug-induced, potentially fatal, cutaneous reaction that is characterized by large areas of skin desquamation and sloughing, similar in many aspects to second-degree burns. The treatment of cutaneous drug reactions rests essentially on immediate (...) diagnosis and recognition of the disease process, accurate history, thorough physical examination, prompt discontinuation of the offending drug, and supportive care. TEN patients are best managed in specialized burn units. Nevertheless, the management remains very much individualized, based on the clinical setting. Topical wound care remains an essential factor in the treatment of burn-like syndromes and is a main determining parameter for morbidity and mortality. As the value of moist environment

2003 Dermatologic Surgery

3954. Calcium homeostasis remains unaffected after 12 weeks' therapy with calcitriol 3 microg/g ointment; no correlation with extent of psoriasis. (Abstract)

topically twice daily for 12 weeks; patients were followed up for a further 8 weeks.There was no alteration of calcium homeostasis: the mean values of albumin-adjusted serum total calcium, as well as 24-hour urinary calcium and serum calcitriol levels, remained within normal ranges throughout treatment. No changes in calcium or phosphate homeostasis related to the area of psoriasis being treated with calcitriol ointment were detected.Reductions in the global severity score and BSA involvement, as well (...) Calcium homeostasis remains unaffected after 12 weeks' therapy with calcitriol 3 microg/g ointment; no correlation with extent of psoriasis. To assess the systemic safety of calcitriol 3 microg/g ointment (Silkis) ointment) in relation to body surface area (BSA) affected by chronic plaque psoriasis.In this open-label, multicentre study, patients were divided into three parallel groups: 5% to <15% (n=23), 15% to <25% (n=18), 25% to 35% (n=18) based on BSA involvement. Ointment was applied

2003 Journal of Dermatological Treatment

3955. Atopic dermatitis management with tacrolimus ointment (Protopic). (Abstract)

Atopic dermatitis management with tacrolimus ointment (Protopic). Tacrolimus ointment is the first of a new class of non-steroidal topical immunomodulators indicated for the treatment of atopic dermatitis. Topical tacrolimus has been subject to an extensive clinical development program involving more than 16,000 patients. A clinical trial program, including vehicle-controlled studies, short- and long-term comparative studies and long-term safety studies, has investigated tacrolimus 0.1 (...) reported to date. Tacrolimus ointment is generally well tolerated, the primary adverse events being mild to moderate and transient application-site reactions: skin burning, pruritus and erythema. Tacrolimus ointment is a significant advance in dermatology and provides physicians with an alternative to conventional topical corticosteroid therapy.

2003 Journal of Dermatological Treatment

3956. Treatment of chronic actinic dermatitis with tacrolimus ointment. (Abstract)

Treatment of chronic actinic dermatitis with tacrolimus ointment. Chronic actinic dermatitis (CAD) is difficult to treat. Topical corticosteroids induce adverse effects after long-term use, especially on light-exposed skin.Our purpose was to study the effects of tacrolimus ointment in the treatment of elderly patients with CAD.In an open trial, 6 male patients between 51 and 80 years old with CAD applied 0.1% tacrolimus ointment twice a day to the face and neck. According to improvements (...) , the frequency of application was reduced. Sunscreen agents were also applied outdoors.Tacrolimus ointment effectively treated cutaneous changes in all patients. Symptoms were moderately improved in 2 weeks, and greatly in 4 weeks. A brief and localized irritating sensation occurred in all patients, but no other adverse events developed throughout the study course from 0.5 to 2.5 years.Topical tacrolimus ointment for facial lesions of CAD appears to be effective and well tolerated and may provide long-term

2002 Journal of American Academy of Dermatology

3957. An open pilot study using tacrolimus ointment in the treatment of seborrheic dermatitis. (Abstract)

An open pilot study using tacrolimus ointment in the treatment of seborrheic dermatitis. Seborrheic dermatitis is generally treated with topical steroids, antifungals, or both. This pilot study was undertaken to examine the possibility of tacrolimus as a useful therapy for seborrheic dermatitis. In a single-center, open-label study, 18 consecutive patients with seborrheic dermatitis were treated with 0.1% tacrolimus for a total of 28 days or until complete clearance occurred, if sooner

2003 Journal of American Academy of Dermatology

3958. Tacrolimus ointment for the treatment of vulvar lichen sclerosus. (Abstract)

Tacrolimus ointment for the treatment of vulvar lichen sclerosus. The treatment of vulvar lichen sclerosus is generally considered difficult. Ultrapotent corticosteroids represent the most effective topical treatment, but carry the risk of side effects such as skin atrophy. We describe a 71-year-old woman with long-standing vulvar lichen sclerosus refractory to conventional treatment. After 6 consecutive weeks of treatment with tacrolimus ointment 0.1% (Protopic) twice daily, signs and symptoms (...) of lichen sclerosus resolved. To our knowledge, this is the first report of the use of topical tacrolimus, which does not induce skin atrophy, in the treatment of vulvar lichen sclerosus.

2003 Journal of American Academy of Dermatology

3959. Eradication of resident bacteria of normal human skin by antimicrobial ointment. Full Text available with Trip Pro

Eradication of resident bacteria of normal human skin by antimicrobial ointment. The application of a topical triple-antibiotic ointment (containing neomycin, polymyxin, and bacitracin) eradicated resident bacteria through 25 layers of the stratum corneum and prevented repopulation of bacteria overnight but not at 1 week. Through 15 layers, mupirocin had some effect, whereas a double-antibiotic ointment had none. The reservoir of resident bacteria in the sebaceous glands is not affected (...) by a topical antibiotic.

2003 Antimicrobial Agents and Chemotherapy

3960. Tacrolimus 0.1% ointment for seborrhoeic dermatitis: an open-label pilot study. (Abstract)

Tacrolimus 0.1% ointment for seborrhoeic dermatitis: an open-label pilot study. As a topical immunosuppressant, tacrolimus ointment may be beneficial in the treatment of seborrhoeic dermatitis, while avoiding adverse effects related to long-term use of topical corticosteroids.To determine the safety and efficacy of topical tacrolimus 0.1% ointment in the treatment of seborrhoeic dermatitis.Sixteen subjects (15 men and one woman) were enrolled in a 6-week, open-label, uncontrolled trial of daily (...) topical tacrolimus 0.1% ointment. Following a 2-week washout period for subjects using conventional therapy for seborrhoeic dermatitis, study medication was applied nightly to affected areas until clinical clearance occurred, and then for 7 days thereafter. Lesional extent and severity were assessed at baseline (day 0), at week 2 and at week 6 using the following parameters: (i). clinical assessment of erythema and scaling using a 0-3 scale; (ii). investigator global assessment; (iii). subject global

2003 British Journal of Dermatology

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