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Topical Ointment

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3861. Localized childhood vulval pemphigoid treated with tacrolimus ointment. (Abstract)

cicatricial pemphigoid, although the autoantigen(s) involved could not be characterized. Her disease responded to treatment with topical tacrolimus ointment 0.1% within 3 months without any evidence for disease activity, except for slight residual scarring. After 12 months, her treatment was stopped without relapse.This observation suggests that in this rare immune-mediated blistering disease topical tacrolimus is an interesting therapeutic option without the adverse effects associated with topical (...) Localized childhood vulval pemphigoid treated with tacrolimus ointment. Localized vulval childhood pemphigoid is a rare variant within the pemphigoid group. Although its prognosis seems favorable, the best therapeutic strategy remains unclear.We here describe the case of an 8-year-old girl presenting with a 5-year history of relapsing vulval pain and lesions suggestive of lichen sclerosus. Clinical features, light microscopy and direct immunofluorescence microscopy were consistent with vulval

2004 Dermatology

3862. Successful treatment of acrodermatitis continua of Hallopeau with sequential combination of calcipotriol and tacrolimus ointments. (Abstract)

Successful treatment of acrodermatitis continua of Hallopeau with sequential combination of calcipotriol and tacrolimus ointments. Acrodermatitis continua of Hallopeau (ACH) is a rare type of pustular psoriasis affecting the digits. We report on a 43-year-old female patient who had been suffering from ACH for more than 20 years. Despite the fact that the disease was localized on one finger during the whole period, several topical and systemic treatments resulted in only temporary or partial (...) improvement of the lesion. Although the monotherapies with calcipotriol and tacrolimus ointments gave no satisfying results in the long-term management of the disease, the combination of both agents led to a continuous improvement of the patient's skin condition.Copyright 2005 S. Karger AG, Basel.

2005 Dermatology

3863. Wet-wrap treatment using dilutions of tacrolimus ointment and fluticasone propionate cream in human APOC1 (+/+) mice with atopic dermatitis. (Abstract)

Wet-wrap treatment using dilutions of tacrolimus ointment and fluticasone propionate cream in human APOC1 (+/+) mice with atopic dermatitis. Wet-wrap treatment (WWT) with diluted topical steroids is widely used in atopic dermatitis (AD). Mice with transgenic overexpression of human apolipoprotein C1 (APOC1) in the liver and the skin are not only characterized by hyperlipidaemia and raised IgE levels, but also by pruritic dermatitis and a disturbed skin barrier function, providing a novel (...) in vivo mouse model for AD.We investigated an adapted WWT method in the AD model in APOC1 mice in order to establish its efficacy.The effect of topical 0.1% and 0.03% tacrolimus ointment, tacrolimus base ointment, different dilutions of 0.05% fluticasone propionate (FP) cream and emollient on the development of dermatitis in APOC1 mice was investigated. WWT was performed with 0.03% tacrolimus ointment or 0.017% FP cream.AD in APOC1 mice responded to topical treatment with tacrolimus or FP. In contrast

2008 British Journal of Dermatology

3864. Successful treatment of perforating granuloma annulare with 0.1% tacrolimus ointment. (Abstract)

Successful treatment of perforating granuloma annulare with 0.1% tacrolimus ointment. Perforating granuloma annulare (PGA) is a rare subtype of granuloma annulare (GA) named in 1971 by Owens and Freeman. It is characterized by necrobiotic areas surrounded by histiocytes and lymphocytes with transepidermal elimination. Many treatments for PGA have been used, often with unsatisfactory results. Tacrolimus in its topical formulation has been established as a safe and effective alternative (...) to topical corticosteroids because of its mild side effects and its minimal systemic absorption. Topical tacrolimus has been approved for the treatment of atopic dermatitis; moreover, ample data exist which demonstrate the usefulness of tacrolimus for the specific treatment of other inflammatory diseases. We report a 70-year-old diabetic woman with PGA, in whom the ulceration due to PGA responded to 0.1% topical tacrolimus.

2008 Journal of Dermatological Treatment

3865. Recalcitrant erosive flexural lichen planus: successful treatment with a combination of thalidomide and 0.1% tacrolimus ointment. (Abstract)

Recalcitrant erosive flexural lichen planus: successful treatment with a combination of thalidomide and 0.1% tacrolimus ointment. A 79-year-old woman has had chronically eroded and ulcerated flexural lichen planus for 12 years, resistant to many forms of treatment. She was successfully treated initially with a combination of topical 0.1% tacrolimus ointment and oral thalidomide and then with topical tacrolimus alone. She has remained free of exacerbations for 12 months and treatment has been (...) well tolerated. Erosive lichen planus involving flexures alone is rare. All reports on treatment of this condition address erosive oral or mucosal lichen planus and both thalidomide and topical tacrolimus have been reported individually to be beneficial.

2004 Clinical & Experimental Dermatology

3866. Molluscum contagiosum in atopic dermatitis treated with 0.1% tacrolimus ointment. (Abstract)

Molluscum contagiosum in atopic dermatitis treated with 0.1% tacrolimus ointment. A case of molluscum contagiosum arising on the face and neck of a woman using topical tacrolimus over a period of 6 weeks for the treatment of atopic dermatitis is presented. Of particular note, these lesions remained confined to areas treated with tacrolimus and did not extend to adjacent regions treated with topical corticosteroids.

2004 Australasian Journal of Dermatology

3867. Successful treatment of nodular actinic reticuloid with tacrolimus ointment. (Abstract)

Successful treatment of nodular actinic reticuloid with tacrolimus ointment. Actinic reticuloid (AR) is the severest clinical variant of chronic actinic dermatitis (CAD) and describes a persistent photoinduced skin disorder often associated with delayed-type hypersensitivity reactions. Histopathologically, AR resembles pseudolymphoma and may also show features of cutaneous lymphoma. In contrast to other UV-induced skin diseases, AR patients show persistent photosensitivity to UV radiation (...) of calcineurin, has been proven successful in various inflammatory skin diseases including atopic eczema, allergic contact dermatitis and photodermatoses without undesired side effects. We present a case of severe recalcitrant and nodular chronic actinic dermatitis responding to topically applied tacrolimus (Protopic). To avoid further relapses we continued this therapy twice a day over a period of 2 years.2006 S. Karger AG, Basel

2006 Dermatology

3868. FK506 promotes melanocyte and melanoblast growth and creates a favourable milieu for cell migration via keratinocytes: possible mechanisms of how tacrolimus ointment induces repigmentation in patients with vitiligo. (Abstract)

FK506 promotes melanocyte and melanoblast growth and creates a favourable milieu for cell migration via keratinocytes: possible mechanisms of how tacrolimus ointment induces repigmentation in patients with vitiligo. Vitiligo is an acquired pigmentary disorder characterized by depigmentation of skin and hair. As the pathogenesis of this disease is still obscure, the treatment of vitiligo has generally been unsatisfactory and often disappointing. Topical tacrolimus (FK506) ointment has recently (...) been added to the armamentarium against this pigmentary disorder. Despite its clinical efficacy, the underlying mechanisms of how topical tacrolimus induces repigmentation in vitiligo have rarely been investigated. As tacrolimus ointment is applied directly to the skin, its impact on keratinocytes (KCs) requires thorough investigation.To investigate the effects of FK506 on melanocyte (MC) and melanoblast (MB) growth via KCs.Cultured MCs and MBs were treated with supernatant of KC cultures

2005 British Journal of Dermatology

3869. Long-term safety and efficacy of tacrolimus ointment for the treatment of atopic dermatitis in children. Full Text available with Trip Pro

Long-term safety and efficacy of tacrolimus ointment for the treatment of atopic dermatitis in children. Tacrolimus ointment is a topical calcineurin inhibitor for the treatment of atopic dermatitis. The primary objective of this open-label study was to assess the long-term safety of tacrolimus ointment. The primary end-point was the incidence of adverse events. Secondary end-points included the Eczema Area and Severity Index and a modified version of this index. A total of 466 children (...) with atopic dermatitis, aged 2-15 years, applied 0.03% or 0.1% tacrolimus ointment twice daily for up to 29.5 months. Skin burning and pruritus were the most common application site events; their prevalence decreased over time. There was no increase in viral infections or other adverse events over time. Laboratory profiles were consistent with those reported in atopic populations. Substantial improvement in all efficacy end-points was observed by week 2 and maintained throughout the study. Long-term

2007 Acta Dermato-Venereologica

3870. Vulvar lichen sclerosus: 11 women treated with tacrolimus 0.1% ointment. Full Text available with Trip Pro

Vulvar lichen sclerosus: 11 women treated with tacrolimus 0.1% ointment. Lichen sclerosus is a chronic relapsing disease, usually treated with ultra-potent corticosteroids. As immunological alterations are considered important aetiopathogenetic factors in lichen sclerosus, the new immunomodulating topical agents, such as tacrolimus and pimecrolimus, have been employed sporadically as alternative therapies. The aim of this study was to evaluate the therapeutic effects of tacrolimus 0.1% ointment (...) in lichen sclerosus in 11 patients unresponsive or poorly responsive to previous treatments. Tacrolimus 0.1% ointment was applied twice daily for 6 weeks, then tapered over a further 6 weeks. Symptoms and objective parameters were evaluated and quantified at the start, after 6 weeks, at the end of the topical treatment, and at follow-up visits. Improvement or remission of symptoms was observed in the patients who completed the study, while objective parameters were poorly influenced and often were

2007 Acta Dermato-Venereologica

3871. Efficacy and safety of tacrolimus ointment 0.03% treatment in a 1-month-old "red baby": a case report. (Abstract)

Efficacy and safety of tacrolimus ointment 0.03% treatment in a 1-month-old "red baby": a case report. Several trials have indicated that topical tacrolimus is safe and effective for several immunologic-based skin disorders. We report a child <2 months old, who was admitted to our pediatric department because of generalized erythroderma. We started tacrolimus ointment 0.03% therapy by applying the ointment to the skin once daily, on a limited surface of 10 cm(2), changing the skin areas only (...) to the treatment was good. We conclude that 0.03% tacrolimus ointment is efficacious and safe even in an infant <2 months of age.

2006 Allergy and Asthma Proceedings

3872. Contact dermatitis with clostridiopeptidase A contained in Noruxol ointment. (Abstract)

Contact dermatitis with clostridiopeptidase A contained in Noruxol ointment. Clostridiopeptidase A, also called collagenase 1, is a proteolytic enzyme capable of digesting collagen. Preparations containing clostridiopeptidase A are used topically for the debridement of dermal ulcers, burns and other necrotic lesions to facilitate the formation of granulation tissue and subsequent epithelization. We observed 4 patients with a periulcerative eczema after repeated applications of Noruxol ointment (...) (Smith & Nephew Ltd, L Hull, UK). Patch testing with Noruxol ointment as is and its excipients (soft paraffin and white petrolatum), as well as scaled dilutions of the main ingredient of this topical preparation, clostridiopeptidase A (Firma, Florence, Italy), showed doubtful reactions to Noruxol ointment in 3 patients and a positive reactions only in 1 patient. All patients showed positive reactions to clostridiopeptidase A 1% in pet. This study shows the sensitizing capacity of clostridiopeptidase

2007 Contact Dermatitis

3873. Tacrolimus ointment causes inflammatory dendritic epidermal cell depletion but no Langerhans cell apoptosis in patients with atopic dermatitis. (Abstract)

Tacrolimus ointment causes inflammatory dendritic epidermal cell depletion but no Langerhans cell apoptosis in patients with atopic dermatitis. The topical immunomodulators tacrolimus and pimecrolimus are novel therapeutic options for atopic dermatitis (AD). The inhibition of nuclear factor of activated T cell-dependent proinflammatory cytokine production in cutaneous lymphocytes is an established effect of topical immunomodulators, which additionally influence mast cells, eosinophils (...) , and dendritic cells (DCs). The latter include a reduced expression of the high-affinity IgE receptor FcepsilonRI, a reduced stimulatory capacity of lesional DCs, and a selective depletion of the inflammatory dendritic epidermal cells (IDECs) but not of Langerhans cells (LCs) from the lesional skin.Because induction of apoptosis in lymphocytes is a reported tacrolimus effect, we asked whether tacrolimus ointment induces apoptosis of LCs or IDECs in AD lesions.Epidermal single-cell suspensions were prepared

2004 Journal of Allergy and Clinical Immunology

3874. Cost-effectiveness analysis of tacrolimus ointment versus high-potency topical corticosteroids in adults with moderate to severe atopic dermatitis

Cost-effectiveness analysis of tacrolimus ointment versus high-potency topical corticosteroids in adults with moderate to severe atopic dermatitis Cost-effectiveness analysis of tacrolimus ointment versus high-potency topical corticosteroids in adults with moderate to severe atopic dermatitis Cost-effectiveness analysis of tacrolimus ointment versus high-potency topical corticosteroids in adults with moderate to severe atopic dermatitis Ellis C N, Drake L A, Prendergast M M, Abramovits W (...) , Boguniewicz M, Daniel C R, Lebwohl M, Paller A S, Stevens S R, Whitaker-Worth D L, Tong K B Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology High-potency topical corticosteroids (HPTCs) were compared with tacrolimus ointment

2003 NHS Economic Evaluation Database.

3875. A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure. (Abstract)

, randomised, double-blind, placebo-controlled trial to test the hypothesis that topical GTN is the best first-line treatment for chronic anal fissure.80 consecutive patients were randomised to receive treatments with topical 0.2% GTN ointment or placebo. Maximum anal resting pressure (MARP) was measured with a constantly perfused side-hole catheter before and after the first application of trial ointment. Anodermal blood flow was measured during manometry by laser Doppler flowmetry. After initial (...) A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure. Anal fissure is most commonly treated surgically by internal anal sphincterotomy. However, there is some concern over the effects of this procedure on continence. Nitric oxide donors such as glyceryl trinitrate (GTN) have been shown to cause a reversible chemical sphincterotomy capable of healing fissures in a small series of cases. This study reports a prospective

1997 Lancet Controlled trial quality: predicted high

3876. A short-term trial of tacrolimus ointment for atopic dermatitis. European Tacrolimus Multicenter Atopic Dermatitis Study Group. Full Text available with Trip Pro

A short-term trial of tacrolimus ointment for atopic dermatitis. European Tacrolimus Multicenter Atopic Dermatitis Study Group. Tacrolimus (FK 506) is an effective immunosuppressant drug for the prevention of rejection after organ transplantation, and preliminary studies suggest that topical application of tacrolimus is effective in the treatment of atopic dermatitis.We conducted a randomized, doubleblind, multicenter study that compared 0.03 percent, 0.1 percent, and 0.3 percent tacrolimus (...) ointment with vehicle alone in patients with moderate to severe atopic dermatitis. The ointment was applied twice daily to a defined, symptomatic area of 200 to 1000 cm2 of skin for three weeks. The primary end point was the change in the summary score for erythema, edema, and pruritus between the first and last days of treatment.After three weeks of treatment, the median percentage decrease in the summary score for dermatitis on the trunk and extremities was 66.7 percent for the 54 patients receiving

1997 NEJM Controlled trial quality: uncertain

3877. Effect of a topical herbal cream on osteoarthritis of the hand and knee: a pilot study. (Abstract)

Effect of a topical herbal cream on osteoarthritis of the hand and knee: a pilot study. To compare the efficacy of an herbal ointment to a sham ointment for relieving pain and stiffness associated with osteoarthritis of the hand and knee.Single-blind, randomized controlled clinical trial conducted in 3 chiropractic medicine practices. Subjects were solicited from patients attending the 3 centers. Selection of subjects with osteoarthritis of the hand or knee was based on the criteria developed (...) by the American College of Rheumatology. Subjects were randomized to an active (n = 17) or a sham (n = 19) group. Subjects applied the herbal ointment to the affected joint(s) for 42 consecutive days and recorded level of pain and stiffness daily on visual analog scales.Thirty subjects completed the study (15 active and 15 sham). Significant differences in pain (P = 0.003) and stiffness (P = 0.0008) were found between the first 21 days of application and the last 21 days of application for the experimental

2003 Journal of Manipulative and Physiological Therapeutics Controlled trial quality: uncertain

3878. Activity of topically applied methylprednisolone aceponate in relation to other topical glucocorticosteroids in healthy volunteers. (Abstract)

Activity of topically applied methylprednisolone aceponate in relation to other topical glucocorticosteroids in healthy volunteers. Topical glucocorticosteroids are useful in the treatment of various skin diseases. Although there are already many corticosteroids available, there is still need for highly potent and well tolerated ones. The anti-inflammatory activity of methylprednisolone aceponate (MPA, CAS 86401-95-8) has been investigated in 165 healthy volunteers of either sex. UV-B (...) irradiation or cellophane tape stripping has served to produce erythema. First, the dose response relationship of MPA ointment (0.01%, 0.05%, 0.1% and 0.5%) has been evaluated. MPA effects have been related to those of the vehicle and difluocortolone 21-valerate 0.1% (DFV) ointment. Then the activity of 0.1% MPA (cream, ointment and fatty ointment) has been related to those of the respective vehicles as well as commercially available preparations of five corticosteroids: betamethasone 17,21-dipropionate

1993 Arzneimittel-Forschung Controlled trial quality: uncertain

3879. The management of puerperal haemorrhoids. A double-blind clinical trial of Anacal rectal ointment. (Abstract)

The management of puerperal haemorrhoids. A double-blind clinical trial of Anacal rectal ointment. 6158736 1980 12 16 2018 11 30 0032-6518 224 1344 1980 Jun The Practitioner Practitioner The management of puerperal haemorrhoids. A double-blind clinical trial of Anacal rectal ointment. 660-1 Ledward R S RS eng Clinical Trial Journal Article Randomized Controlled Trial England Practitioner 0404245 0032-6518 0 Anacal 0 Anesthetics, Local 0 Anti-Inflammatory Agents 0 Disinfectants 0 Drug (...) Combinations 0 Heparinoids 3WJQ0SDW1A Polyethylene Glycols 9PHQ9Y1OLM Prednisolone IWW5FV6NK2 Hexachlorophene IM Administration, Topical Anesthetics, Local therapeutic use Anti-Inflammatory Agents therapeutic use Clinical Trials as Topic Disinfectants therapeutic use Double-Blind Method Drug Combinations therapeutic use Female Hemorrhoids drug therapy Heparinoids therapeutic use Hexachlorophene therapeutic use Humans Polyethylene Glycols therapeutic use Prednisolone Pregnancy Puerperal Disorders drug

1980 The Practitioner Controlled trial quality: predicted high

3880. Nitroglycerin ointment as aid to venepuncture. (Abstract)

Nitroglycerin ointment as aid to venepuncture. 6145869 1984 07 30 2015 06 16 0140-6736 1 8391 1984 Jun 23 Lancet (London, England) Lancet Nitroglycerin ointment as aid to venepuncture. 1416-7 Lohmann M M Møller P P Brynitz S S Bjerrum O W OW eng Clinical Trial Letter Randomized Controlled Trial England Lancet 2985213R 0140-6736 0 Ointments G59M7S0WS3 Nitroglycerin AIM IM Adult Clinical Trials as Topic Double-Blind Method Female Humans Male Middle Aged Nitroglycerin administration & dosage (...) Ointments Punctures methods Veins 1984 6 23 1984 6 23 0 1 1984 6 23 0 0 ppublish 6145869 S0140-6736(84)91918-4

1984 Lancet (London, England) Controlled trial quality: uncertain

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