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Topical Ointment

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3821. Successful treatment of acrodermatitis continua of Hallopeau with sequential combination of calcipotriol and tacrolimus ointments. (Abstract)

Successful treatment of acrodermatitis continua of Hallopeau with sequential combination of calcipotriol and tacrolimus ointments. Acrodermatitis continua of Hallopeau (ACH) is a rare type of pustular psoriasis affecting the digits. We report on a 43-year-old female patient who had been suffering from ACH for more than 20 years. Despite the fact that the disease was localized on one finger during the whole period, several topical and systemic treatments resulted in only temporary or partial (...) improvement of the lesion. Although the monotherapies with calcipotriol and tacrolimus ointments gave no satisfying results in the long-term management of the disease, the combination of both agents led to a continuous improvement of the patient's skin condition.Copyright 2005 S. Karger AG, Basel.

2005 Dermatology

3822. Successful treatment of nodular actinic reticuloid with tacrolimus ointment. (Abstract)

Successful treatment of nodular actinic reticuloid with tacrolimus ointment. Actinic reticuloid (AR) is the severest clinical variant of chronic actinic dermatitis (CAD) and describes a persistent photoinduced skin disorder often associated with delayed-type hypersensitivity reactions. Histopathologically, AR resembles pseudolymphoma and may also show features of cutaneous lymphoma. In contrast to other UV-induced skin diseases, AR patients show persistent photosensitivity to UV radiation (...) of calcineurin, has been proven successful in various inflammatory skin diseases including atopic eczema, allergic contact dermatitis and photodermatoses without undesired side effects. We present a case of severe recalcitrant and nodular chronic actinic dermatitis responding to topically applied tacrolimus (Protopic). To avoid further relapses we continued this therapy twice a day over a period of 2 years.2006 S. Karger AG, Basel

2006 Dermatology

3823. Recalcitrant erosive flexural lichen planus: successful treatment with a combination of thalidomide and 0.1% tacrolimus ointment. (Abstract)

Recalcitrant erosive flexural lichen planus: successful treatment with a combination of thalidomide and 0.1% tacrolimus ointment. A 79-year-old woman has had chronically eroded and ulcerated flexural lichen planus for 12 years, resistant to many forms of treatment. She was successfully treated initially with a combination of topical 0.1% tacrolimus ointment and oral thalidomide and then with topical tacrolimus alone. She has remained free of exacerbations for 12 months and treatment has been (...) well tolerated. Erosive lichen planus involving flexures alone is rare. All reports on treatment of this condition address erosive oral or mucosal lichen planus and both thalidomide and topical tacrolimus have been reported individually to be beneficial.

2004 Clinical & Experimental Dermatology

3824. Molluscum contagiosum in atopic dermatitis treated with 0.1% tacrolimus ointment. (Abstract)

Molluscum contagiosum in atopic dermatitis treated with 0.1% tacrolimus ointment. A case of molluscum contagiosum arising on the face and neck of a woman using topical tacrolimus over a period of 6 weeks for the treatment of atopic dermatitis is presented. Of particular note, these lesions remained confined to areas treated with tacrolimus and did not extend to adjacent regions treated with topical corticosteroids.

2004 Australasian Journal of Dermatology

3825. Long-term safety and efficacy of tacrolimus ointment for the treatment of atopic dermatitis in children. Full Text available with Trip Pro

Long-term safety and efficacy of tacrolimus ointment for the treatment of atopic dermatitis in children. Tacrolimus ointment is a topical calcineurin inhibitor for the treatment of atopic dermatitis. The primary objective of this open-label study was to assess the long-term safety of tacrolimus ointment. The primary end-point was the incidence of adverse events. Secondary end-points included the Eczema Area and Severity Index and a modified version of this index. A total of 466 children (...) with atopic dermatitis, aged 2-15 years, applied 0.03% or 0.1% tacrolimus ointment twice daily for up to 29.5 months. Skin burning and pruritus were the most common application site events; their prevalence decreased over time. There was no increase in viral infections or other adverse events over time. Laboratory profiles were consistent with those reported in atopic populations. Substantial improvement in all efficacy end-points was observed by week 2 and maintained throughout the study. Long-term

2007 Acta Dermato-Venereologica

3826. Vulvar lichen sclerosus: 11 women treated with tacrolimus 0.1% ointment. Full Text available with Trip Pro

Vulvar lichen sclerosus: 11 women treated with tacrolimus 0.1% ointment. Lichen sclerosus is a chronic relapsing disease, usually treated with ultra-potent corticosteroids. As immunological alterations are considered important aetiopathogenetic factors in lichen sclerosus, the new immunomodulating topical agents, such as tacrolimus and pimecrolimus, have been employed sporadically as alternative therapies. The aim of this study was to evaluate the therapeutic effects of tacrolimus 0.1% ointment (...) in lichen sclerosus in 11 patients unresponsive or poorly responsive to previous treatments. Tacrolimus 0.1% ointment was applied twice daily for 6 weeks, then tapered over a further 6 weeks. Symptoms and objective parameters were evaluated and quantified at the start, after 6 weeks, at the end of the topical treatment, and at follow-up visits. Improvement or remission of symptoms was observed in the patients who completed the study, while objective parameters were poorly influenced and often were

2007 Acta Dermato-Venereologica

3827. Gentamicin ointment versus petrolatum for management of auricular wounds. (Abstract)

Gentamicin ointment versus petrolatum for management of auricular wounds. Surgeons frequently create defects on the ear in the treatment of cutaneous malignancies. Potentially significant complications of second-intention healing on the ear are suppurative and inflammatory chondritis. Consequently, many physicians advocate the use of oral or topical prophylactic antibiotics after auricular surgery.The purpose of this study is to compare the efficacy of gentamicin ointment (...) with that of petrolatum for the prevention of suppurative chondritis during second-intention healing of auricular wounds after Mohs surgery.One hundred forty-two patients with a total of 147 second-intention wounds were prospectively selected to receive either gentamicin ointment or petrolatum postoperatively.One hundred forty-four wounds were evaluated in a follow-up examination or by telephone interview. Eight (5.56%) wounds developed suppurative chondritis. Four wounds received gentamicin and four received

2005 Dermatologic Surgery

3828. FK506 promotes melanocyte and melanoblast growth and creates a favourable milieu for cell migration via keratinocytes: possible mechanisms of how tacrolimus ointment induces repigmentation in patients with vitiligo. (Abstract)

FK506 promotes melanocyte and melanoblast growth and creates a favourable milieu for cell migration via keratinocytes: possible mechanisms of how tacrolimus ointment induces repigmentation in patients with vitiligo. Vitiligo is an acquired pigmentary disorder characterized by depigmentation of skin and hair. As the pathogenesis of this disease is still obscure, the treatment of vitiligo has generally been unsatisfactory and often disappointing. Topical tacrolimus (FK506) ointment has recently (...) been added to the armamentarium against this pigmentary disorder. Despite its clinical efficacy, the underlying mechanisms of how topical tacrolimus induces repigmentation in vitiligo have rarely been investigated. As tacrolimus ointment is applied directly to the skin, its impact on keratinocytes (KCs) requires thorough investigation.To investigate the effects of FK506 on melanocyte (MC) and melanoblast (MB) growth via KCs.Cultured MCs and MBs were treated with supernatant of KC cultures

2005 British Journal of Dermatology

3829. Randomized clinical trial comparing botulinum toxin injections with 0.2 per cent nitroglycerin ointment for chronic anal fissure. (Abstract)

Randomized clinical trial comparing botulinum toxin injections with 0.2 per cent nitroglycerin ointment for chronic anal fissure. In recent years treatment of chronic anal fissure has shifted from surgical to medical. This study compared the ability of two non-surgical treatments-botulinum toxin injections and nitroglycerin ointment-to induce healing in patients with idiopathic anal fissure.One hundred adults were assigned randomly to receive treatment with either type A botulinum toxin (30 (...) units Botox or 90 units Dysport) injected into the internal anal sphincter or 0.2 per cent nitroglycerin ointment applied three times daily for 8 weeks.After 2 months, the fissures were healed in 46 (92 per cent) of 50 patients in the botulinum toxin group and in 35 (70 per cent) of 50 in the nitroglycerin group (P=0.009). Three patients in the botulinum toxin group and 17 in the nitroglycerin group reported adverse effects (P<0.001). Those treated with botulinum toxin had mild incontinence

2007 British Journal of Surgery Controlled trial quality: uncertain

3830. Cost-effectiveness analysis of tacrolimus ointment versus high-potency topical corticosteroids in adults with moderate to severe atopic dermatitis

Cost-effectiveness analysis of tacrolimus ointment versus high-potency topical corticosteroids in adults with moderate to severe atopic dermatitis Cost-effectiveness analysis of tacrolimus ointment versus high-potency topical corticosteroids in adults with moderate to severe atopic dermatitis Cost-effectiveness analysis of tacrolimus ointment versus high-potency topical corticosteroids in adults with moderate to severe atopic dermatitis Ellis C N, Drake L A, Prendergast M M, Abramovits W (...) , Boguniewicz M, Daniel C R, Lebwohl M, Paller A S, Stevens S R, Whitaker-Worth D L, Tong K B Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology High-potency topical corticosteroids (HPTCs) were compared with tacrolimus ointment

2003 NHS Economic Evaluation Database.

3831. A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure. (Abstract)

, randomised, double-blind, placebo-controlled trial to test the hypothesis that topical GTN is the best first-line treatment for chronic anal fissure.80 consecutive patients were randomised to receive treatments with topical 0.2% GTN ointment or placebo. Maximum anal resting pressure (MARP) was measured with a constantly perfused side-hole catheter before and after the first application of trial ointment. Anodermal blood flow was measured during manometry by laser Doppler flowmetry. After initial (...) A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure. Anal fissure is most commonly treated surgically by internal anal sphincterotomy. However, there is some concern over the effects of this procedure on continence. Nitric oxide donors such as glyceryl trinitrate (GTN) have been shown to cause a reversible chemical sphincterotomy capable of healing fissures in a small series of cases. This study reports a prospective

1997 Lancet Controlled trial quality: predicted high

3832. A short-term trial of tacrolimus ointment for atopic dermatitis. European Tacrolimus Multicenter Atopic Dermatitis Study Group. Full Text available with Trip Pro

A short-term trial of tacrolimus ointment for atopic dermatitis. European Tacrolimus Multicenter Atopic Dermatitis Study Group. Tacrolimus (FK 506) is an effective immunosuppressant drug for the prevention of rejection after organ transplantation, and preliminary studies suggest that topical application of tacrolimus is effective in the treatment of atopic dermatitis.We conducted a randomized, doubleblind, multicenter study that compared 0.03 percent, 0.1 percent, and 0.3 percent tacrolimus (...) ointment with vehicle alone in patients with moderate to severe atopic dermatitis. The ointment was applied twice daily to a defined, symptomatic area of 200 to 1000 cm2 of skin for three weeks. The primary end point was the change in the summary score for erythema, edema, and pruritus between the first and last days of treatment.After three weeks of treatment, the median percentage decrease in the summary score for dermatitis on the trunk and extremities was 66.7 percent for the 54 patients receiving

1997 NEJM Controlled trial quality: uncertain

3833. Effect of a topical herbal cream on osteoarthritis of the hand and knee: a pilot study. (Abstract)

Effect of a topical herbal cream on osteoarthritis of the hand and knee: a pilot study. To compare the efficacy of an herbal ointment to a sham ointment for relieving pain and stiffness associated with osteoarthritis of the hand and knee.Single-blind, randomized controlled clinical trial conducted in 3 chiropractic medicine practices. Subjects were solicited from patients attending the 3 centers. Selection of subjects with osteoarthritis of the hand or knee was based on the criteria developed (...) by the American College of Rheumatology. Subjects were randomized to an active (n = 17) or a sham (n = 19) group. Subjects applied the herbal ointment to the affected joint(s) for 42 consecutive days and recorded level of pain and stiffness daily on visual analog scales.Thirty subjects completed the study (15 active and 15 sham). Significant differences in pain (P = 0.003) and stiffness (P = 0.0008) were found between the first 21 days of application and the last 21 days of application for the experimental

2003 Journal of Manipulative and Physiological Therapeutics Controlled trial quality: uncertain

3834. Activity of topically applied methylprednisolone aceponate in relation to other topical glucocorticosteroids in healthy volunteers. (Abstract)

Activity of topically applied methylprednisolone aceponate in relation to other topical glucocorticosteroids in healthy volunteers. Topical glucocorticosteroids are useful in the treatment of various skin diseases. Although there are already many corticosteroids available, there is still need for highly potent and well tolerated ones. The anti-inflammatory activity of methylprednisolone aceponate (MPA, CAS 86401-95-8) has been investigated in 165 healthy volunteers of either sex. UV-B (...) irradiation or cellophane tape stripping has served to produce erythema. First, the dose response relationship of MPA ointment (0.01%, 0.05%, 0.1% and 0.5%) has been evaluated. MPA effects have been related to those of the vehicle and difluocortolone 21-valerate 0.1% (DFV) ointment. Then the activity of 0.1% MPA (cream, ointment and fatty ointment) has been related to those of the respective vehicles as well as commercially available preparations of five corticosteroids: betamethasone 17,21-dipropionate

1993 Arzneimittel-Forschung Controlled trial quality: uncertain

3835. A report of 76 cases of chondromalacia patellae treated with an ointment. (Abstract)

Ointments IM Administration, Topical Adolescent Adult Drugs, Chinese Herbal therapeutic use Female Humans Male Middle Aged Ointments Osteomalacia drug therapy Patella 1997 3 1 0 0 1999 8 7 0 1 1997 3 1 0 0 ppublish 10437243 (...) A report of 76 cases of chondromalacia patellae treated with an ointment. 10437243 1999 09 10 2016 10 20 0255-2922 17 1 1997 Mar Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan J Tradit Chin Med A report of 76 cases of chondromalacia patellae treated with an ointment. 40-3 Wang L L Shanghai Traditional Chinese Medicine Clinic. eng Case Reports Clinical Trial Journal Article Randomized Controlled Trial China J Tradit Chin Med 8211546 0255-2922 0 Drugs, Chinese Herbal 0

1999 Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Controlled trial quality: uncertain

3836. A comparative study of Fucidin Ointment and Cicatrin Cream in the treatment of impetigo. (Abstract)

Fusidic Acid I16QD7X297 Neomycin IM Adolescent Adult Aged Bacitracin therapeutic use Child Child, Preschool Clinical Trials as Topic Drug Combinations Female Fusidic Acid therapeutic use Humans Impetigo drug therapy Infant Male Middle Aged Neomycin therapeutic use Ointments Random Allocation 1981 4 1 1981 4 1 0 1 1981 4 1 0 0 ppublish 7028065 (...) A comparative study of Fucidin Ointment and Cicatrin Cream in the treatment of impetigo. 7028065 1982 01 09 2018 11 30 0007-0947 35 4 1981 Apr The British journal of clinical practice Br J Clin Pract A comparative study of Fucidin Ointment and Cicatrin Cream in the treatment of impetigo. 153-5 Cassels-Brown G G eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial England Br J Clin Pract 0372546 0007-0947 0 Drug Combinations 0 Ointments 1405-87-4 Bacitracin 59XE10C19C

1982 The British journal of clinical practice Controlled trial quality: uncertain

3837. A multi-centre general practice trial comparing Fucidin Ointment and Fucidin Cream. (Abstract)

Adult Aged Child Child, Preschool Clinical Trials as Topic Double-Blind Method Emulsions Female Fusidic Acid administration & dosage therapeutic use Humans Infant Male Middle Aged Ointments Random Allocation Skin Diseases, Infectious drug therapy 1981 4 1 1981 4 1 0 1 1981 4 1 0 0 ppublish 7028066 (...) A multi-centre general practice trial comparing Fucidin Ointment and Fucidin Cream. 7028066 1982 01 09 2013 11 21 0007-0947 35 4 1981 Apr The British journal of clinical practice Br J Clin Pract A multi-centre general practice trial comparing Fucidin Ointment and Fucidin Cream. 157-60 Baldwin R J RJ Cranfield R R eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial England Br J Clin Pract 0372546 0007-0947 0 Emulsions 0 Ointments 59XE10C19C Fusidic Acid IM Adolescent

1982 The British journal of clinical practice Controlled trial quality: uncertain

3838. Lithium ointment for genital herpes. (Abstract)

Lithium ointment for genital herpes. 6135115 1983 08 26 2017 09 20 0140-6736 2 8344 1983 Jul 30 Lancet (London, England) Lancet Lithium ointment for genital herpes. 288 Skinner G R GR eng Clinical Trial Letter Randomized Controlled Trial England Lancet 2985213R 0140-6736 0 Ointments 0 Organometallic Compounds 0 Succinates 9FN79X2M3F Lithium MD64P82Y28 lithium succinate AIM IM Clinical Trials as Topic Double-Blind Method Female Herpes Genitalis drug therapy Humans Lithium therapeutic use Male (...) Ointments Organometallic Compounds Random Allocation Succinates therapeutic use 1983 7 30 1983 7 30 0 1 1983 7 30 0 0 ppublish 6135115 S0140-6736(83)90275-1

1983 Lancet (London, England) Controlled trial quality: uncertain

3839. Nitroglycerine ointment as an aid to venepuncture. (Abstract)

Nitroglycerine ointment as an aid to venepuncture. 6130335 1983 03 24 2015 06 16 0140-6736 1 8320 1983 Feb 12 Lancet (London, England) Lancet Nitroglycerine ointment as an aid to venepuncture. 332-3 Hecker J F JF Lewis G B GB Stanley H H eng Clinical Trial Journal Article Randomized Controlled Trial England Lancet 2985213R 0140-6736 0 Ointments G59M7S0WS3 Nitroglycerin AIM IM Adolescent Adult Aged Catheterization Clinical Trials as Topic Humans Infusions, Parenteral Middle Aged Nitroglycerin (...) administration & dosage Ointments Preoperative Care Random Allocation Veins 1983 2 12 1983 2 12 0 1 1983 2 12 0 0 ppublish 6130335 S0140-6736(83)91631-8

1983 Lancet (London, England) Controlled trial quality: uncertain

3840. The management of puerperal haemorrhoids. A double-blind clinical trial of Anacal rectal ointment. (Abstract)

The management of puerperal haemorrhoids. A double-blind clinical trial of Anacal rectal ointment. 6158736 1980 12 16 2018 11 30 0032-6518 224 1344 1980 Jun The Practitioner Practitioner The management of puerperal haemorrhoids. A double-blind clinical trial of Anacal rectal ointment. 660-1 Ledward R S RS eng Clinical Trial Journal Article Randomized Controlled Trial England Practitioner 0404245 0032-6518 0 Anacal 0 Anesthetics, Local 0 Anti-Inflammatory Agents 0 Disinfectants 0 Drug (...) Combinations 0 Heparinoids 3WJQ0SDW1A Polyethylene Glycols 9PHQ9Y1OLM Prednisolone IWW5FV6NK2 Hexachlorophene IM Administration, Topical Anesthetics, Local therapeutic use Anti-Inflammatory Agents therapeutic use Clinical Trials as Topic Disinfectants therapeutic use Double-Blind Method Drug Combinations therapeutic use Female Hemorrhoids drug therapy Heparinoids therapeutic use Hexachlorophene therapeutic use Humans Polyethylene Glycols therapeutic use Prednisolone Pregnancy Puerperal Disorders drug

1980 The Practitioner Controlled trial quality: predicted high

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