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Topical Ointment

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181. Comparison of clotrimazole cream, Whitfield's ointment and Nystatin ointment for the topical treatment of ringworm infections, pityriasis versicolor, erythrasma and candidiasis. (PubMed)

Comparison of clotrimazole cream, Whitfield's ointment and Nystatin ointment for the topical treatment of ringworm infections, pityriasis versicolor, erythrasma and candidiasis. 4582719 1973 12 13 2012 11 15 0007-0963 89 3 1973 Sep The British journal of dermatology Br. J. Dermatol. Comparison of clotrimazole cream, Whitfield's ointment and Nystatin ointment for the topical treatment of ringworm infections, pityriasis versicolor, erythrasma and candidiasis. 297-303 Clayton Y M YM Connor B L BL (...) eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial England Br J Dermatol 0004041 0007-0963 0 Benzoates 0 Imidazoles 0 Salicylates 0 Trityl Compounds 1400-61-9 Nystatin IM Administration, Topical Adolescent Adult Aged Benzoates administration & dosage therapeutic use Candida albicans isolation & purification Candidiasis, Cutaneous drug therapy Clinical Trials as Topic Corynebacterium isolation & purification Female Humans Imidazoles administration & dosage therapeutic

1973 The British journal of dermatology

182. Topical glyceryl trinitrate ointment for pain related to anal hypertonia after stapled hemorrhoidopexy: a randomized controlled trial. (PubMed)

Topical glyceryl trinitrate ointment for pain related to anal hypertonia after stapled hemorrhoidopexy: a randomized controlled trial. Postoperative pain after stapled hemorrhoidopexy is cause for considerable concern and may be related to contracture of continence muscles.We compared glyceryl trinitrate 0.4% ointment with lidocaine chlorohydrate 2.5% gel as topical therapy to relieve the pain of anorectal muscular spasm after stapled hemorrhoidopexy.This was a single-blind, parallel-group (...) , randomized controlled trial.The study was conducted at a university teaching hospital in Rome, Italy.Patients with severe postoperative anal pain after stapled hemorrhoidopexy, clinical evidence of anal hypertonia, and elevated anal resting pressure on manometric assessment were enrolled. Patients treated for concomitant anorectal disease were excluded.Participants were randomly assigned to receive twice-daily, local topical application of glyceryl trinitrate or lidocaine for a total of 14 days.Pain

2013 Diseases of the Colon & Rectum

183. The comparison of efficacy of adcortyl ointment and topical tacrolimus in treatment of erosive oral lichen planus. (PubMed)

The comparison of efficacy of adcortyl ointment and topical tacrolimus in treatment of erosive oral lichen planus. Oral lichen planus (OLP) is a common chronic mucocutaneous disease. Patients with atrophic and erosive lichen planus often have symptoms of soreness and need proper treatment. The main therapy of OLP has been the administration of topical or systemic corticosteroids. Potent topical corticosteroids have been increasingly prescribed in the treatment of erosive lichen planus (...) . The purpose of this study was to compare the efficacy of adcortyl ointment (triamcinolone in orabase) with topical tacrolimus for the treatment of erosive oral lichen planus.Sixty Patients with histopathologically confirmed oral lichen planus were enrolled in the study. The severity of lesions was scored from 0 to 5 according to the criteria described in a previous study. Patients were randomly given adcortyl (group A) and topical tacrolimus ointment (group B) and asked to apply the medication on dried

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2013 Journal of dental research, dental clinics, dental prospects

184. Comparative evaluation of topical calcipotriol versus coal tar and salicylic acid ointment in chronic plaque psoriasis. (PubMed)

Comparative evaluation of topical calcipotriol versus coal tar and salicylic acid ointment in chronic plaque psoriasis. Calcipotriol is a newer topical treatment option available for plaque psoriasis and coal tar being one of the oldest treatment and still in use.To evaluate and compare the differences in terms of efficacy, safety and relapse with Calcipotriol 0.005% (50 mcg/gm) and 6% coal tar and 3% salicylic ointment in patients with Plaque psoriasis. SETTING andStudy conducted on 60 (...) patients of plaque psoriasis, who attended the skin OPD in our hospital.The patients with mild to moderate plaque psoriasis were selected. 60 patients were enrolled for the study after obtaining informed consent. Subjects were asked to apply Calcipotriol 0.005% (50 mcg/gm) (Heximar Win care) twice a day on the right side plaques and on left side plaques, Petroleum jelly (Vaseline) in the morning and 6% coal tar and 3% salicylic ointment (Protar® Percos) at nighttime. PASI score was used to assess

2013 Journal of drugs in dermatology : JDD

185. Antimicrobial Efficacy and Wound Healing Property of a Topical Ointment Containing Nitric Oxide-Loaded Zeolite. (PubMed)

Antimicrobial Efficacy and Wound Healing Property of a Topical Ointment Containing Nitric Oxide-Loaded Zeolite. Topical delivery of nitric oxide (NO) through a wound dressing has the potential to reduce wound infections and improve healing of acute and chronic wounds. This study characterized the antibacterial efficacy of an ointment containing NO-loaded, zinc-exchanged zeolite A that releases NO upon contact with water. The release rate of NO from the ointment was measured using (...) a chemiluminescence detection system. Minimum bactericidal concentration assays were performed using five common wound pathogens, including Gram-negative bacteria (Escherichia coli and Acinetobacter baumannii), Gram-positive bacteria (Staphylococcus epidermidis and meticillin-resistant Staphylococcus aureus) and a fungus (Candida albicans). The time dependence of antimicrobial activity was characterized by performing log-reduction assays at four time points after 1-8 h ointment exposure. The cytotoxicity

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2013 Journal of Medical Microbiology

186. Topical glyceryl trinitrate ointment for pain related to anal hypertonia after stapled hemorrhoidopexy: a randomized controlled trial. (PubMed)

Topical glyceryl trinitrate ointment for pain related to anal hypertonia after stapled hemorrhoidopexy: a randomized controlled trial. Postoperative pain after stapled hemorrhoidopexy is cause for considerable concern and may be related to contracture of continence muscles.We compared glyceryl trinitrate 0.4% ointment with lidocaine chlorohydrate 2.5% gel as topical therapy to relieve the pain of anorectal muscular spasm after stapled hemorrhoidopexy.This was a single-blind, parallel-group (...) , randomized controlled trial.The study was conducted at a university teaching hospital in Rome, Italy.Patients with severe postoperative anal pain after stapled hemorrhoidopexy, clinical evidence of anal hypertonia, and elevated anal resting pressure on manometric assessment were enrolled. Patients treated for concomitant anorectal disease were excluded.Participants were randomly assigned to receive twice-daily, local topical application of glyceryl trinitrate or lidocaine for a total of 14 days.Pain

2013 Diseases of the colon and rectum

187. A comparative study to evaluate efficacy, safety and cost-effectiveness between Whitfield's ointment + oral fluconazole versus topical 1% butenafine in tinea infections of skin. (PubMed)

A comparative study to evaluate efficacy, safety and cost-effectiveness between Whitfield's ointment + oral fluconazole versus topical 1% butenafine in tinea infections of skin. The aim of this study is to compare the efficacy, safety and cost-effectiveness of topical Whitfield's ointment plus oral fluconazole with topical 1% butenafine in tinea infections of the skin.Patients were randomly allocated to the two treatment groups and advised to apply either agent topically twice-a-day for 4 weeks (...) on the lesions and fluconazole (150 mg) was administered once a week for 4 weeks in the study group applying Whitfield's ointment. Patients were followed-up at an interval of 10 days for clinical score and global evaluation response was assessed at baseline and during each follow-up.Out of 120 patients enrolled in the study 103 completed the study. Patients treated with Whitfield's ointment and oral fluconazole reduced mean sign and symptom score from 8.81 ± 0.82 to 0.18 ± 0.59 while butenafine treated

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2013 Indian journal of pharmacology

188. Topical Green Tea Ointment in Treatment of Superficial Skin Cancer

Topical Green Tea Ointment in Treatment of Superficial Skin Cancer Topical Green Tea Ointment in Treatment of Superficial Skin Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Topical Green Tea (...) signalling, an important component of the WNT pathway. Sinecatechins 10% ointment (Veregen®) is a standardized extract of green tea leaves of the species Camellia sinensis, containing mainly green tea polyphenols, particularly catechins (more than 85%). The lead catechin in sinecatechins ointment is EGCG. It is approved by the US Food and Drug Administration (FDA) for genital warts in adults. There are no clinical trials on human subjects with topical EGCG on sBCC yet. With this trial we are the first

2013 Clinical Trials

189. Retapamulin 1% Ointment and Clobetasol Propionate 0.05% Foam is More Efficacious than Vehicle Ointment and Clobetasol 0.05% Propionate Foam in the Treatment of Hand/Foot Dermatitis: A Single Center, Randomized, Double-blind Study. (PubMed)

a higher clearance of Staphylococcus aureus colonization, when compared to vehicle (placebo) ointment and clobetasol propionate 0.05% foam.Adult subjects with moderate to very severe hand/foot dermatitis had twice-daily topical application of clobetasol propionate 0.05% foam to hands/feet for 14 days and were randomized to apply either retapamulin 1% ointment or vehicle ointment twice daily to hands/feet and nares for five days.Seventy-three percent of subjects in the retapamulin/clobetasol group were (...) Retapamulin 1% Ointment and Clobetasol Propionate 0.05% Foam is More Efficacious than Vehicle Ointment and Clobetasol 0.05% Propionate Foam in the Treatment of Hand/Foot Dermatitis: A Single Center, Randomized, Double-blind Study. Staphylococcus aureus has been implicated in the pathogenesis of adult hand/foot dermatitis.The authors hypothesized that retapamulin 1% ointment and clobetasol propionate 0.05% foam would decrease disease severity in subjects with hand/foot dermatitis and provide

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2014 The Journal of clinical and aesthetic dermatology

190. An open label prospective randomized trial to compare the efficacy of coal tar-salicylic Acid ointment versus calcipotriol/betamethasone dipropionate ointment in the treatment of limited chronic plaque psoriasis. (PubMed)

An open label prospective randomized trial to compare the efficacy of coal tar-salicylic Acid ointment versus calcipotriol/betamethasone dipropionate ointment in the treatment of limited chronic plaque psoriasis. Chronic plaque psoriasis is a common papulosquamous skin disorder, for which a number of topical agents are being used including coal tar, topical steroids and more recently topical calcipotriol/betamethasone dipropionate. There is no study comparing purified coal tar preparation (...) with calcipotriol/betamethasone dipropionate ointment in limited chronic plaque psoriasis.A prospective randomized open label controlled trial to compare the efficacy and safety of topical application of coal tar-salicylic acid ointment with calcipotriol/betamethasone dipropionate ointment applied once at night for 12 weeks for the treatment of limited chronic plaque psoriasis.A total of 62 patients of limited chronic plaque psoriasis (body surface area <10%) were randomized into two treatment groups: Group

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2014 Indian journal of dermatology

191. Total Occlusive Ionic Silver-Containing Dressing vs Mupirocin Ointment Application vs Conventional Dressing in Elective Colorectal Surgery: Effect on Incisional Surgical Site Infection (PubMed)

and standard dressing groups; a significant difference was observed between ISD and MOA (relative risk [RR] 4.5; 95% CI (1.1 to 19.8); p = 0.046) and between the standard group and the MOA group (RR 5; 95% CI (1.2 to 21.7); p = 0.031).Topical application of mupirocin ointment achieves better results for the prevention of SSI than ionic silver-containing dressing or standard dressing in patients undergoing elective open colorectal surgery.Copyright © 2015 American College of Surgeons. Published by Elsevier (...) Total Occlusive Ionic Silver-Containing Dressing vs Mupirocin Ointment Application vs Conventional Dressing in Elective Colorectal Surgery: Effect on Incisional Surgical Site Infection Several pre- and intraoperative factors have been associated with incisional surgical site infection (SSI), but little is known about the influence of postoperative wound care and especially, the use of different dressings on incisional SSI. The aim of this study was to compare 3 methods of wound dressings

2015 EvidenceUpdates

192. The onset risk of carcinoma in patients continuing tacrolimus topical treatment for oral lichen planus: a case report (PubMed)

The onset risk of carcinoma in patients continuing tacrolimus topical treatment for oral lichen planus: a case report Oral lichen planus is a chronic inflammatory mucocutaneous disease. Topical use of steroids and other immuno-modulating therapies have been tried for this intractable condition. Nowadays, tacrolimus ointment is used more commonly as a choice for treatment. However, a number of discussions have taken place after tacrolimus was reported to be carcinogenic. This report describes (...) a patient who applied tacrolimus ointment to the lower lip after being diagnosed with oral lichen planus in 2008, and whose lesion developed squamous cell carcinoma in 2010. Since the relationship between tacrolimus and cancer development has been reported in only a few cases, including this case report, the clinician must be careful selecting tacrolimus as a second-line treatment for oral lichen planus.

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2016 Odontology

193. Topical administration

with the child/ young person and family ( ): discuss what the treatment involves and duration discuss reasons for administration and application discuss side effects of treatment provide written information give a named contact Administration Gather the following equipment: ( ) topical cream/ointment silver foil bowls plastic spoon apron gloves (ensure non latex) ( ) Wash hands and put on apron and gloves ( ). Check topical cream/ointment with prescription chart adhering to hospital medicine administration (...) policy for identifying correct patient ( ). Apply patient named sticker onto cream tube/bottle ( ). If cream/ointment does not come in a tube or pump dispenser, decant sufficient cream for that administration into a silver foil bowl with plastic spoon ( ). Ensure the child’s/young person’s skin is cleansed thoroughly with a disposable washcloth and prescribed soap substitute ( ). If the child/young person is having a bath prior to topical administration, a bath emollient should be used to reduce

2015 Great Ormond Street Hospital

194. Systematic review of the use of topical diltiazem compared with glyceryltrinitrate for the nonoperative management of chronic anal fissure

Systematic review of the use of topical diltiazem compared with glyceryltrinitrate for the nonoperative management of chronic anal fissure Systematic review of the use of topical diltiazem compared with glyceryltrinitrate for the nonoperative management of chronic anal fissure Systematic review of the use of topical diltiazem compared with glyceryltrinitrate for the nonoperative management of chronic anal fissure Sajid MS, Whitehouse PA, Sains P, Baig MK CRD summary The review concluded (...) outcome variables: side effects, headache, recurrence and healing rate. Diltiazem (2%) was applied twice daily in five out of six studies and three times a day in one study; where reported, between 250mg and 700mg was applied. All studies used 0.2% glyceryl trinitrate ointment. In most studies the treatments were given for six to eight weeks. Mean group ages ranged from 30 to 54 years. In one study all participants were instructed to follow a high fibre diet. All studies used clinical/digital rectal

2013 DARE.

195. Atopic dermatitis – Treatment with topical therapies

: 171–176 | , x 53 Bieber, T., Vick, K., Folster-Holst, R., Belloni-Fortina, A., Stadtler, G., Worm, M. et al. Efficacy and safety of methylprednisolone aceponate ointment 0.1% compared to tacrolimus 0.03% in children and adolescents with an acute flare of severe atopic dermatitis. Allergy . 2007 ; 62 : 184–189 | | | Proactive use of TCS for maintenance B II x 54 Schmitt, J., von Kobyletzki, L., Svensson, A., and Apfelbacher, C. Efficacy and tolerability of proactive treatment with topical (...) propionate 0.005% ointment in the long-term maintenance treatment of children with atopic dermatitis: differences between boys and girls?. Pediatr Allergy Immunol . 2009 ; 20 : 59–66 | | | Need for consideration of side effects with use A I x 57 Callen, J., Chamlin, S., Eichenfield, L.F., Ellis, C., Girardi, M., Goldfarb, M. et al. A systematic review of the safety of topical therapies for atopic dermatitis. Br J Dermatol . 2007 ; 156 : 203–221 | | | , x 58 Pariser, D. Topical corticosteroids and topical

2014 American Academy of Dermatology

196. Efficacy, safety and tolerability of an optimized avulsion technique with onyster® (40% urea ointment with plastic dressing) ointment compared to bifonazole-urea ointment for removal of the clinically infected nail in toenail onychomycosis: a randomized (PubMed)

Efficacy, safety and tolerability of an optimized avulsion technique with onyster® (40% urea ointment with plastic dressing) ointment compared to bifonazole-urea ointment for removal of the clinically infected nail in toenail onychomycosis: a randomized Toenail onychomycosis is highly prevalent, with 14-28% of people aged 60 or over suffering from the disease. Use of a topical antifungal alone in toenail onychomycosis is associated with low cure rates. This may be due to limited penetration (...) of the topical antifungal through the diseased nail. The objective of the present study was to compare two treatment modalities to obtain diseased nail chemical avulsion in toenail onychomycosis.In this European, multicenter, randomized, parallel-group, open-label, active-controlled study, male or female adult patients with distal-lateral or lateral subungual dermatophyte onychomycosis on at least 12.5% of the great toenail were randomized either to a 40% urea ointment with plastic dressing group (n = 53

2013 Dermatology (Basel, Switzerland)

197. Randomized study of topical tacrolimus ointment as possible treatment for resistant idiopathic pruritus ani. (PubMed)

Randomized study of topical tacrolimus ointment as possible treatment for resistant idiopathic pruritus ani. 22243728 2012 02 29 2013 11 21 1097-6787 66 2 2012 Feb Journal of the American Academy of Dermatology J. Am. Acad. Dermatol. Randomized study of topical tacrolimus ointment as possible treatment for resistant idiopathic pruritus ani. 327-8 10.1016/j.jaad.2011.05.024 Suys Erwin E eng Letter Randomized Controlled Trial United States J Am Acad Dermatol 7907132 0190-9622 0 Placebos (...) WM0HAQ4WNM Tacrolimus IM Administration, Topical Adult Cross-Over Studies Female Humans Male Middle Aged Placebos Pruritus Ani drug therapy Tacrolimus administration & dosage 2010 10 23 2011 05 19 2011 05 19 2012 1 17 6 0 2012 1 17 6 0 2012 3 1 6 0 ppublish 22243728 S0190-9622(11)00599-8 10.1016/j.jaad.2011.05.024

2012 Journal of the American Academy of Dermatology

198. Hair regrowth with topical triiodothyronine ointment in patients with alopecia areata: a double-blind, randomized pilot clinical trial of efficacy. (PubMed)

Hair regrowth with topical triiodothyronine ointment in patients with alopecia areata: a double-blind, randomized pilot clinical trial of efficacy. Thyroid hormone receptors are expressed in hair follicles and it is known that thyroid hormones can have a positive effect on hair growth, i.e. process which is disrupted in alopecia areata.The aim of this study was to determine the efficacy of topical triiodothyronine in patients with patchy alopecia areata.Ten patients with patchy alopecia areata

2012 Journal of the European Academy of Dermatology and Venereology : JEADV

199. Topical silver sulfadiazine vs collagenase ointment for the treatment of partial thickness burns in children: a prospective randomized trial. (PubMed)

Topical silver sulfadiazine vs collagenase ointment for the treatment of partial thickness burns in children: a prospective randomized trial. The 2 most commonly used topical agents for partial thickness burns are silver sulfadiazine (SSD) and collagenase ointment (CO). Silver sulfadiazine holds antibacterial properties, and eschar separation occurs naturally. Collagenase ointment is an enzyme that cleaves denatured collagen facilitating separation but has no antibacterial properties. Currently (...) if not healed.From January 2008 to January 2011, 100 patients were enrolled, with no differences in patient characteristics. There were no differences in clinical course, outcome, or need for skin grafting. Wound infections occurred in 7 patients treated with CO and 1 patient treated with SSD (P = .06). Collagenase ointment was more expensive than SSD (P < .001). However, total hospital charges did not differ.There are no differences in outcomes between topical SSD or CO in the management of childhood burns

2012 Journal of pediatric surgery

200. Topically applied semaphorin 3A ointment inhibits scratching behavior and improves skin inflammation in NC/Nga mice with atopic dermatitis. (PubMed)

Topically applied semaphorin 3A ointment inhibits scratching behavior and improves skin inflammation in NC/Nga mice with atopic dermatitis. Epidermal hyperinnervation in atopic dermatitis (AD) is activated directly by various external stimuli, causing enhanced itching. Nerve density is regulated by the nerve repulsion factor semaphorin 3A (Sema3A), along with nerve elongation factors.To investigate the effects of Sema3A ointment in the NC/Nga mouse model of AD.An AD-like phenotype was induced (...) by repeated application of Dermatophagoides farinae body (Dfb) ointment to the dorsal skin of NC/Nga mice. Vaseline, heparinoid, betamethasone, tacrolimus and recombinant Sema3A ointments were applied to the lesional skin once a day for 4 days. Transepidermal water loss (TEWL) was measured before and after each treatment. We also scored the degree of dermatitis and recorded videos to observe scratching behavior. Subsequently, we collected skin samples from these mice for histological analyses.Topical

2012 Journal of dermatological science

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