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Topical Ointment

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1. Chronic anal fissure: 0.2% topical glyceryl trinitrate ointment

Chronic anal fissure: 0.2% topical glyceryl trinitrate ointment Chronic anal fissure: 0.2% topical gly Chronic anal fissure: 0.2% topical glyceryl ceryl trinitr trinitrate ointment ate ointment Evidence summary Published: 26 March 2013 nice.org.uk/guidance/esuom7 pathways K Ke ey points from the e y points from the evidence vidence The content of this evidence summary was up-to-date in March 2013. See summaries of product characteristics (SPCs), British national formulary (BNF), BNF (...) . It is not known whether applying less ointment of the same strength, rather than reducing the strength of ointment applied, might have an effect on the incidence or headache. The evidence for unlicensed 2% topical diltiazem hydrochloride is discussed in detail in the evidence summary Chronic anal fissure: 2% topical diltiazem hydrochloride. About this e About this evidence summary vidence summary 'Evidence summaries: unlicensed or off-label medicines' summarise the published evidence for selected unlicensed

2013 National Institute for Health and Clinical Excellence - Advice

2. Effectiveness, safety, and economic evaluation of topical application of a herbal ointment, Jaungo, for radiation dermatitis after breast conserving surgery in patients with breast cancer (GREEN study): Study protocol for a randomized controlled trial. (Full text)

Effectiveness, safety, and economic evaluation of topical application of a herbal ointment, Jaungo, for radiation dermatitis after breast conserving surgery in patients with breast cancer (GREEN study): Study protocol for a randomized controlled trial. This is a prospective, open-label, parallel-group, randomized controlled trial that evaluates the effectiveness and safety of adjuvant application of Jaungo (JUG) for radiation-induced dermatitis (RD) in breast cancer patients undergoing (...) radiation therapy, in comparison with general supportive care (GSC).Eighty female patients, who have been diagnosed with unilateral breast cancer, will be allocated to either the JUG or GSC group with an allocation ratio of 1:1 after breast conservation surgery, in the Kyung Hee University Korean Medicine Hospital, Seoul, Republic of Korea. Both the groups will be subjected to GSC, but only the JUG group participants will apply adjuvant JUG ointment on the irradiated skin for 6 weeks, twice a day

2019 Medicine Controlled trial quality: uncertain

3. A Cost-utility Analysis of Calcipotriol/betamethasone Dipropionate Aerosol Foam versus Ointment for the Topical Treatment of Psoriasis Vulgaris in Sweden. (Full text)

A Cost-utility Analysis of Calcipotriol/betamethasone Dipropionate Aerosol Foam versus Ointment for the Topical Treatment of Psoriasis Vulgaris in Sweden. Psoriasis is a chronic inflammatory disorder that imposes a substantial economic burden. We conducted a cost-utility analysis from a Swedish healthcare payers perspective using a decision-tree model with a 12-week time horizon. Patients with psoriasis vulgaris could have two 4-week cycles of topical treatment with calcipotriol 50 µg/g (...) and betamethasone 0.5 mg/g as dipropionate (Cal/BD) foam or Cal/BD ointment before progressing to phototherapy/methotrexate. In the base-case analysis, Cal/BD foam dominated over Cal/BD ointment. The increased efficacy of Cal/BD foam resulted in fewer consultations and a decreased risk of progressing to phototherapy/methotrexate. Although Cal/BD foam costs more than Cal/BD ointment, this was offset by lower costs for phototherapy/methotrexate or consultation visits. Sensitivity analyses revealed that the base

2019 Acta Dermato-Venereologica

4. Assessment of topical corticosteroid ointment on postcesarean scars prevention: A prospective clinical trial. (Full text)

Assessment of topical corticosteroid ointment on postcesarean scars prevention: A prospective clinical trial. To evaluate the effectiveness of corticosteroid ointment in hypertrophic scars prevention following Cesarean section.This study was conducted between June 2017-May 2018 in Acıbadem Kozyatagı Hospital. Sixty-one patients (31 treatment and 30 control patients) took part in the current study which evaluated wound outcomes and patient satisfaction. All patients' wound characteristics were

2019 Pakistan Journal Of Medical Sciences Controlled trial quality: uncertain

5. Calcipotriol ointment shows comparable efficacy to topical steroids in chronic hand eczema. (PubMed)

Calcipotriol ointment shows comparable efficacy to topical steroids in chronic hand eczema. Topical potent corticosteroids are the mainstay of treatment for chronic hand eczema (CHE). However, there are numerous adverse effects associated with the chronic use of topical corticosteroids. Calcipotriol has been widely used in psoriasis and has been reported to achieve beneficial effects in several inflammatory diseases. This study aimed to evaluate the efficacy and safety of calcipotriol ointment (...) compared to desoximetasone ointment in the treatment of CHE. Patch testing was performed in all recruited subjects. Then, each hand of the patient was randomly allocated for the application of either calcipotriol ointment or desoximetasone ointment twice daily for 8 weeks. Recurrence was assessed 4 weeks after discontinuation of the treatment. The Hand eczema severity index (HECSI) scores, quartile grading assessments and digital photographs were evaluated. Adverse reactions were also monitored

2019 Dermatologic therapy Controlled trial quality: uncertain

6. Bacteriology of primary pyodermas and comparative efficacy of topical application of mupirocin and sodium fusidate ointments in their treatment. (PubMed)

Bacteriology of primary pyodermas and comparative efficacy of topical application of mupirocin and sodium fusidate ointments in their treatment. A study to compare the efficacy of topical 2% mupirocin ointment and 2% topical sodium fusidate ointment in the treatment of primary pyodermas was done. Out of one hundred cases of primary pyodermas, fifty were randomly treated with 2% topical mupirocin ointment and fifty were given 2% topical sodium fusidate ointment. Patients were evaluated after

2019 Indian journal of dermatology, venereology and leprology Controlled trial quality: uncertain

7. An Excellent Response to Topical Therapy of Four CHILD Syndrome Patients with an Increased Concentration of Simvastatin Ointment. (PubMed)

An Excellent Response to Topical Therapy of Four CHILD Syndrome Patients with an Increased Concentration of Simvastatin Ointment. Congenital hemidysplasia with ichthyosiform erythroderma and limb defects (CHILD) syndrome is a rare X-linked dominant disorder characterized by peculiar cutaneous presentations and ipsilateral skeletal abnormalities, caused by mutations in NAD (P) H steroid dehydrogenaselike (NSDHL) gene.1 Its defect leads to the deficiency of cholesterol and the accumulation

2019 Journal of the European Academy of Dermatology and Venereology

8. Comparison the effects of topical application of olive and calendula ointments on Children's diaper dermatitis: A triple-blind randomized clinical trial. (PubMed)

Comparison the effects of topical application of olive and calendula ointments on Children's diaper dermatitis: A triple-blind randomized clinical trial. This study compares the effective of of topical application of olive and calendula ointments on childrens' diaper dermatitis (DD). This triple-blind clinical trial was conducted on 73 healthy children under the age of 2 years with non-severe and not infected DD, referred to a pediatric healthcare center in Tabriz, Iran. The children were (...) assigned to 1.5% olive ointment (n = 37) and 1.5% calendula ointment (n = 39) using a random block method with the ratio of 2:2. The severity of DD in both groups was measured and compared on a six-point scale on days 0 (before the intervention) and 3, 5, and 7 after interventions. The findings releaved there was not significant stastistical difference between the olive oil and calendula groups in terms of severity of DD in the third, fifth and seventh days. No adverse effect was reported from either

2018 Dermatologic therapy Controlled trial quality: uncertain

9. Study to Evaluate the Efficacy, Safety, and Tolerability of Topical VDA-1102 Ointment in Subjects With Actinic Keratosis

Study to Evaluate the Efficacy, Safety, and Tolerability of Topical VDA-1102 Ointment in Subjects With Actinic Keratosis Study to Evaluate the Efficacy, Safety, and Tolerability of Topical VDA-1102 Ointment in Subjects With Actinic Keratosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Study to Evaluate the Efficacy, Safety, and Tolerability of Topical VDA-1102 Ointment in Subjects With Actinic Keratosis (Phase2b) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our

2018 Clinical Trials

10. Open-Label Study of RVT-501 Topical Ointment in Pediatric Patients With Atopic Dermatitis

Open-Label Study of RVT-501 Topical Ointment in Pediatric Patients With Atopic Dermatitis Open-Label Study of RVT-501 Topical Ointment in Pediatric Patients With Atopic Dermatitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Open-Label Study of RVT-501 Topical Ointment in Pediatric Patients With Atopic Dermatitis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03415282 Recruitment Status : Active, not recruiting First Posted : January 30, 2018 Last Update Posted : May 11, 2018 Sponsor: Dermavant

2018 Clinical Trials

11. A Study to Evaluate the Sensitizing Potential of CCP-020 (Diacerein 1%) Topical Ointment in Healthy Subjects Using a Repeat Insult Patch Test Design

A Study to Evaluate the Sensitizing Potential of CCP-020 (Diacerein 1%) Topical Ointment in Healthy Subjects Using a Repeat Insult Patch Test Design A Study to Evaluate the Sensitizing Potential of CCP-020 (Diacerein 1%) Topical Ointment in Healthy Subjects Using a Repeat Insult Patch Test Design - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved (...) Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study to Evaluate the Sensitizing Potential of CCP-020 (Diacerein 1%) Topical Ointment in Healthy Subjects Using a Repeat Insult Patch Test Design The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our

2018 Clinical Trials

12. A 21-Day Study to Evaluate the Skin Irritation Potential of CCP-020 (Diacerein 1%) Topical Ointment in Healthy Subjects Using a Cumulative Irritant Patch Test Design

A 21-Day Study to Evaluate the Skin Irritation Potential of CCP-020 (Diacerein 1%) Topical Ointment in Healthy Subjects Using a Cumulative Irritant Patch Test Design A 21-Day Study to Evaluate the Skin Irritation Potential of CCP-020 (Diacerein 1%) Topical Ointment in Healthy Subjects Using a Cumulative Irritant Patch Test Design - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x (...) × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A 21-Day Study to Evaluate the Skin Irritation Potential of CCP-020 (Diacerein 1%) Topical Ointment in Healthy Subjects Using a Cumulative Irritant Patch Test Design The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated

2018 Clinical Trials

13. Autochthonous and persistent cutaneous larva migrans in an infant successfully treated by topic albendazole ointment. (PubMed)

Autochthonous and persistent cutaneous larva migrans in an infant successfully treated by topic albendazole ointment. 30468533 2018 12 07 1468-3083 2018 Nov 23 Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Autochthonous and persistent cutaneous larva migrans in an infant successfully treated by topic albendazole ointment. 10.1111/jdv.15356 Robert M G MG Parasitology-Mycology, University Hospital Grenoble-Alpes, Grenoble, France. Faisant

2018 Journal of the European Academy of Dermatology and Venereology

14. Efficacy of topical 2% mupirocin ointment for treatment of tympanostomy tube otorrhea caused by community-acquired methicillin resistant Staphylococcus aureus. (PubMed)

Efficacy of topical 2% mupirocin ointment for treatment of tympanostomy tube otorrhea caused by community-acquired methicillin resistant Staphylococcus aureus. To demonstrate the safety and effectiveness of topical 2% mupirocin ointment as an adjunctive therapy for tympanostomy tube otorrhea (TTO) caused by methicillin-resistant Staphylococcus aureus (MRSA).We treated children with community-acquired MRSA TTO by aural suctioning and culture-directed systemic antibiotics (+/- ototopical drops (...) ) alone (control group) or with the addition of single 1 ml dose of mupirocin ointment applied to the tube and ear canal (mupirocin group). Patient age, laterality, response to treatment, associate hearing loss, duration of follow-up, and recurrence of infection by MRSA or by other organisms were compared.29 children (37 ears) with MRSA TTO were included. 8 children (12 ears) received adjunctive topical mupirocin ointment - 21 children (25 ears) did not. 8 of 12 ears in the mupirocin group received

2018 International Journal of Pediatric Otorhinolaryngology

15. Efficacy and adverse effects of topical chloramphenicol ointment use for surgical wounds: a systematic review. (PubMed)

Efficacy and adverse effects of topical chloramphenicol ointment use for surgical wounds: a systematic review. Chloramphenicol ointment is often used in plastic and dermatologic surgery as a topical antibiotic for surgical wounds, but evidence regarding its efficacy and side effects is lacking. In addition, anecdotal fear of aplastic anaemia exists from the oral use of this drug. We performed a systematic review of the literature to assess the efficacy and side effect profile of topical (...) chloramphenicol ointment on non-ocular surgical wounds.A systematic search of MEDLINE, EMBASE and the Cochrane Library from inception until 4 September 2017 was undertaken. Clinical studies of topical chloramphenicol ointment use on surgical wounds were included. Studies looking only at ocular use or those not available in full text or English were excluded. The review was conducted adhering to PRISMA guidelines.After full-text review, five articles were included. Two were randomized controlled trials, one

2018 ANZ journal of surgery

16. Reduction of postoperative pain and improvement of patients' comfort after Milligan-Morgan hemorrhoidectomy using topical application of vitamin E ointment. (PubMed)

Reduction of postoperative pain and improvement of patients' comfort after Milligan-Morgan hemorrhoidectomy using topical application of vitamin E ointment. 26715437 2017 04 03 2017 04 03 1432-1262 31 7 2016 Jul International journal of colorectal disease Int J Colorectal Dis Reduction of postoperative pain and improvement of patients' comfort after Milligan-Morgan hemorrhoidectomy using topical application of vitamin E ointment. 1371-2 10.1007/s00384-015-2483-4 Ruiz-Tovar Jaime J Department (...) Montiel M Department of Surgery, Coloproctology Unit, University Hospital King Juan Carlos, Gladiolo, s/n, 28933, Mostoles, Madrid, Spain. Garia-Olmo Damian D Department of Surgery, Coloproctology Unit, University Hospital King Juan Carlos, Gladiolo, s/n, 28933, Mostoles, Madrid, Spain. eng Letter Randomized Controlled Trial 2015 12 29 Germany Int J Colorectal Dis 8607899 0179-1958 1406-18-4 Vitamin E IM Administration, Topical Adult Aged Female Hemorrhoidectomy adverse effects Humans Length of Stay

2017 International journal of colorectal disease Controlled trial quality: uncertain

17. Successful Management of Zoon’s Balanitis with Topical Mupirocin Ointment: A Case Report and Literature Review of Mupirocin-Responsive Balanitis Circumscripta Plasmacelluaris (Full text)

Successful Management of Zoon’s Balanitis with Topical Mupirocin Ointment: A Case Report and Literature Review of Mupirocin-Responsive Balanitis Circumscripta Plasmacelluaris Zoon's balanitis, also referred to as balanitis circumscripta plasmacellularis (BCP), is an idiopathic, benign inflammatory condition of the glans penis and foreskin most often seen in elderly uncircumcised men. A patient with a biopsy-confirmed diagnosis of BCP who was successfully treated with topical mupirocin (...) ointment is described.The PubMed database was searched with the key words: bactroban, balanitis, cell, circumscripta, mupirocin, plasma, plasmacellularis, tacrolimus, Zoon. The papers generated by the search and their references were reviewed.Treatments for BCP have previously included circumcision and topical calcineurin inhibitors. Our patient with BCP rapidly resolved after initiating treatment with mupirocin 2% ointment.BCP is a benign dermatosis affecting the glans penis and foreskin. We confirm

2017 Dermatology and therapy

18. Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma: A Randomized Clinical Trial (Full text)

Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma: A Randomized Clinical Trial 28793140 2019 01 28 2019 01 28 2168-6084 153 10 2017 10 01 JAMA dermatology JAMA Dermatol Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma: A Randomized Clinical Trial. 1061-1063 10.1001/jamadermatol.2017.2529 Kessels Janneke J Department of Dermatology, Maastricht University Medical Center, Maastricht, the Netherlands. GROW School for Developmental Biology (...) . Kelleners-Smeets Nicole W J NWJ Department of Dermatology, Maastricht University Medical Center, Maastricht, the Netherlands. GROW School for Developmental Biology and Oncology, Maastricht University, Maastricht, the Netherlands. eng Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't United States JAMA Dermatol 101589530 2168-6068 0 Ointments 0 green tea extract polyphenone E 8R1V1STN48 Catechin AIM IM Administration, Topical Biopsy Camellia sinensis Carcinoma, Basal Cell

2017 JAMA dermatology Controlled trial quality: predicted high

19. Topical diltiazem ointment in post-hemorrhoidectomy pain relief: A meta-analysis of randomized controlled trials. (Full text)

Topical diltiazem ointment in post-hemorrhoidectomy pain relief: A meta-analysis of randomized controlled trials. Hemorrhoidectomy is commonly associated with postoperative pain. Calcium channel blockers are known to cause relaxation of gastrointestinal smooth muscle and oral diltiazem has also been shown to reduce the resting anal pressure.We attempted to analyze efficacy and side effects of topical diltiazem oint. in post-operative pain control.This is a meta-analysis of patients who (...) underwent hemorrhoidectomy using topical diltiazem oint. versus placebo (Vaseline) for pain control. Patients with third or fourth degree hemorrhoids undergoing traditional hemorrhoidectomy were included. Procedures took place in the colorectal division of a hospital in 5 countries. Five randomized control trials (RCTs) published between 2005 and 2016 including 227 patients were included our meta-analysis (Diltiazem (calcium channel block) group = 137; Placebo (Vaseline) group = 90). Pain assessment

2017 Asian Journal of Surgery

20. A Comparison of the Effects of Topical Prolavacid Solution (a Polyhexamethylene Biguanide-Based Wound Cleanser) and Medihoney Ointment in a Rat Model of Cutaneous Wound (Full text)

A Comparison of the Effects of Topical Prolavacid Solution (a Polyhexamethylene Biguanide-Based Wound Cleanser) and Medihoney Ointment in a Rat Model of Cutaneous Wound Objective: This experimental work examined the healing effect and probable adverse impact of topical Prolavacid® solution (a polyhexamethylene biguanide-based wound cleanser) and topical Medihoney ointment in an animal model of cutaneous wound. Approach: We randomly divided 22 adult Sprague-Dawley rats (all were male) in two (...) groups (n = 11): (1) those for which Prolavacid solution was poured on the skin wound surface; and (2) those animals for which Medihoney® ointment was applied to the wounds. These two agents were applied daily throughout the study period (21 days). We photographically followed the wounds' contraction with imaging performed on days 0, 7, and 21 postwounding. The histopathologic features of the healing wounds were evaluated using skin biopsies taken on days 7 and 21 postwounding. Results

2017 Advances in wound care

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