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Topical NSAID

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161. Steroid Aromatase Inhibitors Versus Progestogens for nSAID-resistanced Late Stage Breast Cancer

Steroid Aromatase Inhibitors Versus Progestogens for nSAID-resistanced Late Stage Breast Cancer Steroid Aromatase Inhibitors Versus Progestogens for nSAID-resistanced Late Stage Breast Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Steroid Aromatase Inhibitors Versus Progestogens for nSAID-resistanced Late Stage Breast Cancer The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02161315 Recruitment Status : Unknown Verified February 2012 by Tianjin Medical University Cancer Institute and Hospital

2014 Clinical Trials

162. Fracture healing and NSAIDs (PubMed)

Fracture healing and NSAIDs 25217677 2015 05 29 2018 11 13 1715-5258 60 9 2014 Sep Canadian family physician Medecin de famille canadien Can Fam Physician Fracture healing and NSAIDs. 817, e439-40 Taylor Ian C IC Family medicine resident and Associate Professor, at the University of Alberta in Edmonton. Lindblad Adrienne J AJ Knowledge Translation and Evidence Coordinator with the Alberta College of Family Physicians. Kolber Michael R MR Associate Professor, at the University of Alberta (...) in Edmonton. eng fre Journal Article Canada Can Fam Physician 0120300 0008-350X 0 Anti-Inflammatory Agents, Non-Steroidal IM Can Fam Physician. 2014 Nov;60(11):985 25392434 Anti-Inflammatory Agents, Non-Steroidal administration & dosage adverse effects Fracture Healing drug effects Fractures, Bone complications Humans Pain drug therapy etiology Randomized Controlled Trials as Topic 2014 9 14 6 0 2014 9 14 6 0 2015 5 30 6 0 ppublish 25217677 60/9/817 PMC4162697 Arch Orthop Trauma Surg. 1993;112(3):127-30

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2014 Canadian Family Physician

163. Relative efficacy and safety of topical non-steroidal anti-inflammatory drugs for osteoarthritis: a systematic review and network meta-analysis of randomised controlled trials and observational studies. (PubMed)

Relative efficacy and safety of topical non-steroidal anti-inflammatory drugs for osteoarthritis: a systematic review and network meta-analysis of randomised controlled trials and observational studies. To compare the efficacy and safety of topical non-steroidal anti-inflammatory drugs (NSAIDs), including salicylate, for the treatment of osteoarthritis (OA).PubMed, Embase, Cochrane Library and Web of Science were searched from 1966 to January 2017. Randomised controlled trials (RCTs) comparing (...) topical NSAIDs with placebo or each other in patients with OA and observational studies comparing topical NSAIDs with no treatment or each other irrespective of disease were included. Two investigators identified studies and independently extracted data. Bayesian network and conventional meta-analyses were conducted. The primary outcomes were pain relief for RCTs and risk of adverse effects (AEs) for observational studies.43 studies, comprising 36 RCTs (7 900 patients with OA) and seven observational

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2018 British Journal of Sports Medicine

164. Adverse effects of topical nonsteroidal antiinflammatory drugs in older adults with osteoarthritis: a systematic literature review

-steroidal anti-inflammatory drugs was safer than oral administration for osteoarthritis in older adults, but that many patients reported systemic adverse effects with topical agents. Reliance on a narrative synthesis, and some lack of reporting in the review process, means the reliability of these conclusions is unclear. Authors' objectives To systematically review literature on reported adverse effects associated with the use of topical non-steroidal anti-inflammatory drugs (NSAIDs) in older adults (...) with osteoarthritis. Searching MEDLINE (from 1950 to November 2009), Scopus, EMBASE, Web of Science, and the Cochrane Library were searched for relevant studies published in English. Search terms were reported. Abstracts from dissertations and American College of Rheumatology meetings were also searched. Bibliographies of reviews and individuals studies were scanned for further studies. Study selection Papers were excluded if they were obviously unrelated to topical non-steroidal anti-inflammatory drugs (NSAIDs

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2010 DARE.

165. A meta-analysis of rectal NSAIDs in the prevention of post-ERCP pancreatitis

SM, Higgins PD. A meta-analysis of rectal NSAIDs in the prevention of post-ERCP pancreatitis. Gut 2008; 57(9): 1262-1267 PubMedID DOI Original Paper URL Indexing Status Subject indexing assigned by NLM MeSH Acute Disease; Administration, Rectal; Anti-Inflammatory Agents, Non-Steroidal /administration & Cholangiopancreatography, Endoscopic Retrograde /adverse effects; Humans; Pancreatitis /etiology /prevention & Randomized Controlled Trials as Topic; control; dosage /therapeutic use (...) A meta-analysis of rectal NSAIDs in the prevention of post-ERCP pancreatitis A meta-analysis of rectal NSAIDs in the prevention of post-ERCP pancreatitis A meta-analysis of rectal NSAIDs in the prevention of post-ERCP pancreatitis Elmunzer BJ, Waljee AK, Elta GH, Taylor JR, Fehmi SM, Higgins PD CRD summary The authors concluded that, in this meta-analysis, prophylactic rectal non-steroidal anti-inflammatory drugs were effective in preventing post-endoscopic retrograde cholangiopancreatography

2008 DARE.

166. Non-steroidal anti-inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults. (PubMed)

Non-steroidal anti-inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults. Lateral elbow pain, or tennis elbow, is a common condition that causes pain in the elbow and forearm. Although self-limiting, it can be associated with significant disability and often results in work absence. It is often treated with topical and oral non-steroidal anti-inflammatory drugs (NSAIDs). This is an update of a review first published in 2002 (search date October 11, 2012).To assess the benefits (...) and harms of topical and oral NSAIDs for treating people with lateral elbow pain.We searched the Cochrane Central Register of Controlled Trials, MEDLINE, CINAHL, EMBASE and SciSearch up to October 11, 2012. No language restriction was applied.Studies were included if they were randomised or quasi-randomised controlled trials (RCTs or CCTs) that compared topical or oral NSAIDs with placebo or another intervention, or compared two NSAIDs in adults with lateral elbow pain. Outcomes of interest were pain

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2013 Cochrane database of systematic reviews (Online)

167. Cardiovascular Risk of NSAIDs: Time to Translate Knowledge into Practice. (PubMed)

Cardiovascular Risk of NSAIDs: Time to Translate Knowledge into Practice. 23424289 2013 07 15 2018 12 02 1549-1676 10 2 2013 PLoS medicine PLoS Med. Cardiovascular risk of NSAIDs: time to translate knowledge into practice. e1001389 10.1371/journal.pmed.1001389 Reddy K Srinath KS Public Health Foundation of India, ISID Campus, Vasant Kunj, New Delhi, India. ksrinath.reddy@phfi.org Roy Ambuj A eng Journal Article Comment 2013 02 12 United States PLoS Med 101231360 1549-1277 0 Anti-Inflammatory (...) Agents, Non-Steroidal 0 Drugs, Essential IM PLoS Med. 2013;10(2):e1001388 23424288 Anti-Inflammatory Agents, Non-Steroidal adverse effects economics Cardiovascular Diseases chemically induced Commerce economics Developed Countries economics Developing Countries economics Drug Costs Drug Industry economics Drugs, Essential adverse effects economics Humans Pharmacopoeias as Topic 2013 2 21 6 0 2013 2 21 6 0 2013 7 17 6 0 ppublish 23424289 10.1371/journal.pmed.1001389 PMEDICINE-D-12-03788 PMC3570557 N

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2013 PLoS medicine

168. NSAID Treatment in Knee Osteoarthritis

NSAID Treatment in Knee Osteoarthritis NSAID Treatment in Knee Osteoarthritis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. NSAID Treatment in Knee Osteoarthritis (NSKO) The safety and scientific validity (...) play a role in pain perception during osteoarthritis (OA).Local inflammation (which involves production of pro-inflammatory cytokines such as interleukin (IL) 4 TNF-alpha, IL-6 and IL-8) is considered to be a major source of pain. Certain therapies that specifically interfere with the expression or actions of pro-inflammatory cytokines have been explored. NSAIDs have analgesic, antipyretic and anti-inflammatory properties and are extensively prescribed for several musculoskeletal disorders. Indeed

2013 Clinical Trials

169. Discontinuing NSAIDs

: Treatment Official Title: Discontinuing NSAIDs in Veterans With Knee Osteoarthritis Actual Study Start Date : September 2, 2013 Actual Primary Completion Date : October 5, 2018 Actual Study Completion Date : October 5, 2018 Resource links provided by the National Library of Medicine related topics: related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Active Treatment Eligible subjects will be randomized to Meloxicam 15 mg po QD vs placebo Drug: Meloxicam (...) Discontinuing NSAIDs Discontinuing NSAIDs - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Discontinuing NSAIDs The safety and scientific validity of this study is the responsibility of the study sponsor

2013 Clinical Trials

170. NSAID Drug Interaction Study

NSAID Drug Interaction Study NSAID Drug Interaction Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. NSAID Drug Interaction Study The safety and scientific validity of this study is the responsibility (...) to evaluate the potential pharmacokinetic (PK) effects of non-steroidal anti-inflammatory drugs on lesinurad and leinurad on the non-steroidal anti-inflammatory drugs. Condition or disease Intervention/treatment Phase Gout Drug: lesinurad 400 mg Drug: naproxen 250 mg Drug: indomethacin 25 mg Phase 1 Detailed Description: Naproxen and indomethacin are non-steroidal anti-inflammatory drugs (NSAIDs) used both prophylactically for the prevention of, and as a treatment for, acute gout flares. RDEA594-126

2013 Clinical Trials

171. East-West Collaboration Treatment Using Bee Venom Acupuncture and NSAIDs for Chronic Cervicalgia

-West Collaborative Treatment Using NSAIDs and BV on Chronic Cervical Pain; A Randomized, Controlled, Parallel, Pilot Study Study Start Date : July 2013 Actual Primary Completion Date : March 2014 Actual Study Completion Date : July 2014 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Bee Venom Acupuncture Procedure: Bee Venom Acupuncture Bee Venom 1:20,000 under BVA Increment Protocol - Increment (...) East-West Collaboration Treatment Using Bee Venom Acupuncture and NSAIDs for Chronic Cervicalgia East-West Collaboration Treatment Using Bee Venom Acupuncture and NSAIDs for Chronic Cervicalgia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2013 Clinical Trials

172. A single dose of a non-steroidal anti-inflammatory drug (NSAID) prevents severe pain after ureteric stent removal: a prospective, randomised, double-blind, placebo-controlled trial. (PubMed)

A single dose of a non-steroidal anti-inflammatory drug (NSAID) prevents severe pain after ureteric stent removal: a prospective, randomised, double-blind, placebo-controlled trial. 23759014 2013 08 15 2013 06 13 1464-410X 112 1 2013 Jul BJU international BJU Int. A single dose of a non-steroidal anti-inflammatory drug (NSAID) prevents severe pain after ureteric stent removal: a prospective, randomised, double-blind, placebo-controlled trial. E1-2 10.1111/bju.12234_2 Garg Manish M Singh (...) Vishwajeet V Sankhwar Satya Narayan SN eng Letter England BJU Int 100886721 1464-4096 0 Anti-Inflammatory Agents, Non-Steroidal IM Anti-Inflammatory Agents, Non-Steroidal administration & dosage therapeutic use Device Removal adverse effects Dose-Response Relationship, Drug Double-Blind Method Humans Pain, Postoperative drug therapy etiology Prospective Studies Randomized Controlled Trials as Topic methods Stents Ureter surgery Ureteral Diseases surgery 2013 6 14 6 0 2013 6 14 6 0 2013 8 16 6 0 ppublish

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2013 BJU international Controlled trial quality: predicted high

173. Topical rubefacients for acute and chronic pain in adults. (PubMed)

studies, so not robust. There were insufficient data to draw conclusions against active controls.The evidence does not support the use of topical rubefacients containing salicylates for acute injuries, and suggests that in chronic conditions their efficacy compares poorly with topical non-steroidal antiinflammatory drugs (NSAIDs). Topical salicylates seem to be relatively well tolerated in the short-term, based on limited data. There is no evidence at all for topical rubefacients with other components. (...) Topical rubefacients for acute and chronic pain in adults. Rubefacients (containing salicylates or nicotinamides) cause irritation of the skin, and are believed to relieve various musculoskeletal pains. They are available on prescription, and are common components in over-the-counter remedies. A non-Cochrane review in 2004 found limited evidence for efficacy.To review current evidence for efficacy and safety of topically applied rubefacients in acute and chronic painful musculoskeletal

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2009 Cochrane

174. Topical Chemoprevention of Skin Cancer Biomarkers

not render a participant ineligible. Radiation therapy Topical medications for the treatment of actinic keratosis or skin cancer (retin A, 5-FU, imiquimod) in the 6 months prior to randomization. Laser resurfacing, dermabrasion, cryotherapy, chemical peel and electrodissection ± curettage in the 6 months prior to randomization. Nasally inhaled corticosteroids (except mometasone - Nasonex) Aspirin (>100 mg/day) - Note: cardioprotective doses (< 100mg/day) are acceptable. NSAIDs (other than aspirin < 100mg (...) reactions to nonsteroidal anti-inflammatory agents or to DFMO Any disease that predisposes to NMSC An immunodeficiency disorder or the use of an immunosuppressive drug Any skin disease that would interfere with interpretation of results Any family history of Ornithine diaminotransferase deficiency in a first degree relative Concurrent use of the following medications or treatments Anticoagulants including warfarin and heparin Other NSAIDs (other than aspirin <100 mg/day) on a daily basis Topical

2015 Clinical Trials

175. Study of SST-0225 Topical Ibuprofen Cream in the Treatment of Delayed Onset Muscle Soreness (DOMS)

Study of SST-0225 Topical Ibuprofen Cream in the Treatment of Delayed Onset Muscle Soreness (DOMS) Study of SST-0225 Topical Ibuprofen Cream in the Treatment of Delayed Onset Muscle Soreness (DOMS) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. Study of SST-0225 Topical Ibuprofen Cream in the Treatment of Delayed Onset Muscle Soreness (DOMS) (DOMS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02597634 Recruitment Status : Completed First Posted : November 5, 2015 Last Update Posted : October 13

2015 Clinical Trials

176. To Study Generic Diclofenac Sodium Topical Gel 1% in the Treatment of Osteoarthritis of the Knee (Degenerative Joint Disease Presented as Joint Pain, Stiffness, Swelling and Restricted Motion).

To Study Generic Diclofenac Sodium Topical Gel 1% in the Treatment of Osteoarthritis of the Knee (Degenerative Joint Disease Presented as Joint Pain, Stiffness, Swelling and Restricted Motion). To Study Generic Diclofenac Sodium Topical Gel 1% in the Treatment of Osteoarthritis of the Knee (Degenerative Joint Disease Presented as Joint Pain, Stiffness, Swelling and Restricted Motion). - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting (...) registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. To Study Generic Diclofenac Sodium Topical Gel 1% in the Treatment of Osteoarthritis of the Knee (Degenerative Joint Disease Presented as Joint Pain, Stiffness, Swelling and Restricted Motion). The safety and scientific validity of this study is the responsibility of the study

2015 Clinical Trials

177. Topical Anesthetic for Procedures Through the Nose

Topical Anesthetic for Procedures Through the Nose Topical Anesthetic for Procedures Through the Nose - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Topical Anesthetic for Procedures Through the Nose (...) Description Go to Brief Summary: To determine if RX0041-002 is a safe and effective topical anesthetic. Condition or disease Intervention/treatment Phase Drug Reaction to Analgesic Nos Drug: RX0041 4% Drug: Placebo Drug: RX0041 8% Phase 3 Detailed Description: This is a phase III single-dose, randomized , placebo and dose-controlled study to evaluate the safety and efficacy of a RX0041-002 topical solution for local anesthesia during diagnostic procedures and surgeries on or through the mucous membranes

2015 Clinical Trials

178. Effect of Topical and Intravenous Tranexamic Acid (TXA) on Thrombogenic Markers in Patients Undergoing Knee Replacement

Effect of Topical and Intravenous Tranexamic Acid (TXA) on Thrombogenic Markers in Patients Undergoing Knee Replacement Effect of Topical and Intravenous Tranexamic Acid (TXA) on Thrombogenic Markers in Patients Undergoing Knee Replacement - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Effect of Topical and Intravenous Tranexamic Acid (TXA) on Thrombogenic Markers in Patients Undergoing Knee Replacement (TXA Knee) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02540226 Recruitment Status : Active

2015 Clinical Trials

179. Hot Topics in Primary Care: Update on the Recognition and Management of Gout: More Than the Great Toe. (PubMed)

Hot Topics in Primary Care: Update on the Recognition and Management of Gout: More Than the Great Toe. Gout is a chronic inflammatory condition that is increasing in prevalence and commonly associated with other chronic diseases such as obesity, diabetes mellitus, hypertension, hypercholesterolemia, chronic kidney disease, cardiovascular disease, and thromboembolic disorders. These associations make the management of patients with gout more complex. Although identification of MSU crystals (...) , typically colchicine or an NSAID, is recommended for management of an acute gout flare, while ULT may be used in patients with frequent or severe acute gout, tophi, urolithiasis, renal function impairment, or other complications of gout. Allopurinol is first-line ULT for most patients, although febuxostat and probenecid are effective options and pegloticase is useful in selected patients. New medications, such as lesinurad, are on the horizon.

2015 Journal of Family Practice

180. Effect of Topical Application of Iodex® Balm on Local Surface Temperature

with no clinically significant and relevant abnormalities of medical history or physical examination Exclusion Criteria: Women of child bearing potential, pregnant and lactating women Intolerance/hypersensitivity to study material/ingredient Recent history of alcohol or drug abuse Participants receiving topical non-steroidal antiinflammatory drugs (NSAIDs), other topical analgesics/counterirritants/mineral oils, or other medication, which might interfere with study results Participants having psoriasis/active (...) Effect of Topical Application of Iodex® Balm on Local Surface Temperature Effect of Topical Application of Iodex® Balm on Local Surface Temperature - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect

2015 Clinical Trials

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