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Topical NSAID

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141. Effect of Topical and Oral Diclofenac on Pain Related to Intravitreal Injections

of intraoperative miosis and for the treatment of seasonal allergic conjunctivitis. The primary goal of this study is to assess the analgesic effect of DIclofenac 0.1% Eye Drops a topical NSAID, as well as a combination of Diclofenac 0.1% Eye Drops and oral Diclofenac Sodium sustained-release (SR) 75mg tablets on pain related to intravitreal injections immediately after and up to six hours post-IVI. A number of patients scheduled to undergo IVIs of anti-VEGFs will be randomized and divided in three groups. All (...) of GI ulceration,bleeding and perforation, renal and hepatic disease and any systemic or topical use of NSAIDs or any use of sedative medications within 7 days from the visit and during the day of IVI. Patients with poor cooperation in understanding and answering the questions of the SF-MPQ, including the visual analogue scale (VAS). Unsuccessful blinding Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact

2016 Clinical Trials

142. A Prospective Study of B244 Delivered as a Topical Spray to Determine Safety and Efficacy in Subjects With Elevated Blood Pressure

A Prospective Study of B244 Delivered as a Topical Spray to Determine Safety and Efficacy in Subjects With Elevated Blood Pressure A Prospective Study of B244 Delivered as a Topical Spray to Determine Safety and Efficacy in Subjects With Elevated Blood Pressure - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have (...) reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Prospective Study of B244 Delivered as a Topical Spray to Determine Safety and Efficacy in Subjects With Elevated Blood Pressure The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02998840

2016 Clinical Trials

143. A Safety, Tolerability, Efficacy and Exposure Study of XEN801 Topical Gel

of acne vulgaris on the face within 14 days of baseline Use of systemic corticosteroids, antibiotics, anti-acne drugs, anti-inflammatory drugs (NSAIDs are permitted) or prescription topical retinoid use on the face within 28 days prior the baseline Initiation of hormonal therapy or dose change to hormonal therapy within 12 weeks prior to baseline. Use of androgen receptor blockers (eg, spironolactone, flutamide) within 12 weeks prior to baseline Use of oral retinoid (eg, isotretinoin, alitretinoin (...) A Safety, Tolerability, Efficacy and Exposure Study of XEN801 Topical Gel A Safety, Tolerability, Efficacy and Exposure Study of XEN801 Topical Gel - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Safety

2016 Clinical Trials

144. Topical Menthol +/- Mannitol for Painful Diabetic Peripheral Neuropathy

Topical Menthol +/- Mannitol for Painful Diabetic Peripheral Neuropathy Topical Menthol +/- Mannitol for Painful Diabetic Peripheral Neuropathy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Topical (...) effective at relieving the pain, the physical limitations and the emotional distress caused by PDPN than the same cream without mannitol. Justification: PDPN is common and can be disabling because of the intensity of the pain it can cause. Less than 50% of those suffering from this condition get adequate pain relief from their current medications. The oral medications, anticonvulsants, antidepressants, NSAIDS, marijuana derivatives and narcotics have numerous side effects and are potentially addictive

2016 Clinical Trials

145. Topical 0.1% Bromfenac Sodium and Prostaglandin E2 Inhibition in Cataract Surgery

prostaglandin E2 (PGE2), are known to play a role in inflammation-induced miosis. Preoperative topical treatment with NSAIDs inhibits the release of prostaglandins in response to surgically-induced miosis by suppressing cyclooxygenase, the enzyme that transforms arachidonic acid into prostaglandin precursors. The effectiveness of ophthalmic NSAIDs in preventing miosis has been well documented in conventional phacoemulsification cataract surgery. However, whether this effect is also applicable to femtosecond (...) laser-assisted cataract surgery is unknown. Yeoh has suggested the addition of NSAID eye drops to the dilation regimen during femtosecond laser cataract surgery, but no randomized study has been conducted to support this theory. Given the increasing popularity of femtosecond laser-assisted cataract surgery, the investigators sought to study whether topical NSAIDs might be beneficial in pupil maintenance and PGE2 inhibition during the procedure. Study Design Go to Layout table for study information

2016 Clinical Trials

146. Bioequivalence Study With Clinical Endpoint for Diclofenac Sodium Topical Gel 1%

). Periarticular knee pain due to osteoarthritis (not bursitis, tendonitis etc.) that required the use of oral or topical treatments (e.g., NSAIDs or acetaminophen). Radiograph of the target knee within the previous year with a Grade 1, 2 or 3 disease based upon the Kellgren-Lawrence disease severity scale. After a minimum of 7-day wash out of all pain medication has Baseline pain on movement score of ≥ 50mm on a 0-100-mm Visual Analogue Scale for the target knee. After a minimum of 7-day wash out of all pain (...) Bioequivalence Study With Clinical Endpoint for Diclofenac Sodium Topical Gel 1% Bioequivalence Study With Clinical Endpoint for Diclofenac Sodium Topical Gel 1% - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2016 Clinical Trials

147. Study of a New Medical Device in Gel Formulation Versus Calgel® for the Topical Treatment of Teething in Infants

and/or immobilization and/or confinement to bed. Infants with known history of severe renal insufficiency and/or known history of severe cardiac dysfunction and/or liver problems Use of topical Lidocaine and/or topical Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) within one day before inclusion. Use of systemic NSAIDs within 3 days before inclusion and/or use of systemic anesthetics within 10 days before. Concomitant use during the period of study of NSAIDs and/or any anesthetics (obviously Calgel® is allowed (...) Study of a New Medical Device in Gel Formulation Versus Calgel® for the Topical Treatment of Teething in Infants Study of a New Medical Device in Gel Formulation Versus Calgel® for the Topical Treatment of Teething in Infants - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2016 Clinical Trials

148. Study of X0002 Following Escalating Single and Multiple Doses Administered as Topical Application in Healthy Volunteers

Study of X0002 Following Escalating Single and Multiple Doses Administered as Topical Application in Healthy Volunteers Study of X0002 Following Escalating Single and Multiple Doses Administered as Topical Application in Healthy Volunteers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Study of X0002 Following Escalating Single and Multiple Doses Administered as Topical Application in Healthy Volunteers The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02794740 Recruitment Status : Completed First

2016 Clinical Trials

149. Topical Treatment With Bromfenac Reduces Retinal Gliosis and Inflammation After Optic Nerve Crush. (PubMed)

Topical Treatment With Bromfenac Reduces Retinal Gliosis and Inflammation After Optic Nerve Crush. To study the effect of topical administration of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID), on retinal gliosis and levels of prostaglandin E2 (PGE2) after complete optic nerve crush (ONC).Adult albino rats were divided into the following groups (n = 8 retinas/group): (1) intact, (2) intact and bromfenac treatment (twice a day during 7 days), (3) ONC (7 days), and (4) ONC (7 days

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2016 Investigative Ophthalmology & Visual Science

150. Corneal Melting after Collagen Cross-Linking for Keratoconus in a Thin Cornea of a Diabetic Patient Treated with Topical Nepafenac: A Case Report with a Literature Review (PubMed)

Corneal Melting after Collagen Cross-Linking for Keratoconus in a Thin Cornea of a Diabetic Patient Treated with Topical Nepafenac: A Case Report with a Literature Review To report the case of a 50-year-old woman with diabetes that presented with corneal melting and perforation 6 weeks after collagen cross-linking (CxL) for keratoconus (KC) and postoperative use of nepafenac eye drops, a nonsteroidal anti-inflammatory drug (NSAID).This is a case report of a patient with diabetes, KC and a thin (...) was associated with multiple risk factors: (1) nepafenac eye drop use, (2) CxL in a cornea thinner than 400 µm and (3) diabetes. The recommended corneal thickness limits should be respected. Topical NSAIDs should be used with caution if used as postoperative treatment after corneal CxL and in patients with diabetes, epithelial defect or delayed healing, because of the possible increased risk for corneal melting when multiple risk factors are observed.

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2016 Case reports in ophthalmology

151. Topical Anti‐Inflammatory and Analgesic Effects of Multiple Applications of S(+)‐Flurbiprofen Plaster (SFPP) in a Rat Adjuvant‐Induced Arthritis Model (PubMed)

Topical Anti‐Inflammatory and Analgesic Effects of Multiple Applications of S(+)‐Flurbiprofen Plaster (SFPP) in a Rat Adjuvant‐Induced Arthritis Model Preclinical Research The aim of this study was to evaluate the efficacy of multiple applications of S(+)-flurbiprofen plaster (SFPP), a novel Nonsteroidal anti-inflammatory drug (NSAID) patch, for the alleviation of inflammatory pain and edema in rat adjuvant-induced arthritis (AIA) model as compared to other NSAID patches. The AIA model (...) was induced by the injection of Mycobacterium butyricum and rats were treated with a patch (1.0 cm × 0.88 cm) containing each NSAID (SFP, ketoprofen, loxoprofen, diclofenac, felbinac, flurbiprofen, or indomethacin) applied to the paw for 6 h per day for 5 days. The pain threshold was evaluated using a flexion test of the ankle joint, and the inflamed paw edema was evaluated using a plethysmometer. cyclooxygenase (COX)-1 and COX-2 inhibition was evaluated using human recombinant proteins. Multiple

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2016 Drug development research

152. Safety and efficacy of topical ketoprofen in transfersome gel in knee osteoarthritis: A systematic review. (PubMed)

Safety and efficacy of topical ketoprofen in transfersome gel in knee osteoarthritis: A systematic review. Topical ketoprofen in Transfersome gel has been used for the alleviation of symptoms in osteoarthritis. Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with various side effects. Topical NSAIDs are known to have a lower side-effect profile when compared with systemic administration. The present systematic review aimed to determine the safety and efficacy of topical ketoprofen (...) in Transfersome gel in knee osteoarthritis (OA).A systematic literature review was performed. The electronic databases EMBASE, MEDLINE, HealthStar and PubMed were searched from 1946 to June 2016. A screen of the reference sections of the included studies was also performed. Two blinded reviewers searched, screened, abstracted and evaluated the data quality using the Jadad scale. Studies were included if they contained: at least 50% of participants with knee OA, topical ketoprofen, human subjects

2016 Musculoskeletal care

153. Topical bromfenac for prevention and treatment of cystoid macular edema following cataract surgery: a review (PubMed)

Topical bromfenac for prevention and treatment of cystoid macular edema following cataract surgery: a review Topical nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids, alone or in combination, have historically been used off label in the US to prevent and treat postoperative cystoid macular edema (CME). This literature review presents available data on the use of bromfenac 0.07% or 0.09% to prevent and treat CME following cataract surgery. Bromfenac is an NSAID approved to treat (...) postoperative inflammation and reduce ocular pain following cataract surgery. Few cases of clinical CME were observed with bromfenac use in a total of 19 reviewed studies. There were no significant differences in CME incidence between bromfenac and corticosteroid-treated patients or between bromfenac- and bromfenac plus corticosteroid-treated patients. Bromfenac demonstrated comparable efficacy to other NSAIDs in preventing CME. Compared with corticosteroids, bromfenac alone or plus a corticosteroid showed

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2016 Clinical ophthalmology (Auckland, N.Z.) Controlled trial quality: uncertain

154. A comparative study of various topical nonsteroidal anti-inflammatory drugs to steroid drops for control of post cataract surgery inflammation. (PubMed)

A comparative study of various topical nonsteroidal anti-inflammatory drugs to steroid drops for control of post cataract surgery inflammation. Postoperative inflammation continues to be a cause of patient discomfort, delayed recovery, and in some cases, suboptimal visual results. Topical nonsteroidal anti-inflammatory drugs (NSAIDs) and steroid are commonly used in the management and prevention of noninfectious ocular inflammation following cataract surgery.The aim was to study the safety (...) and efficacy of various NSAIDs drops for control of postoperative inflammation following cataract surgery and compare with steroid eye drops in a patient following cataract surgery.Totally, 200 patients undergoing phacoemulsification with posterior chamber intraocular lens implantation were randomly assigned to receive either nepafenac 0.1% 3 times daily, bromfenac 0.09% twice daily, ketorolac 0.5% 4 times daily for 1 month or 1% prednisolone eye drops as their postoperative anti-inflammatory medication

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2016 Oman journal of ophthalmology Controlled trial quality: uncertain

155. Topical Application of Cocaine HCl 4%, or 10%, or Placebo Solution in Local (Topical) Anesthesia

Topical Application of Cocaine HCl 4%, or 10%, or Placebo Solution in Local (Topical) Anesthesia Topical Application of Cocaine HCl 4%, or 10%, or Placebo Solution in Local (Topical) Anesthesia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Topical Application of Cocaine HCl 4%, or 10%, or Placebo Solution in Local (Topical) Anesthesia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02500836 Recruitment Status : Completed First Posted : July 17, 2015 Results First Posted : May 16, 2017 Last Update

2015 Clinical Trials

156. Pharmacologic prophylaxis of post-endoscopic retrograde cholangiopancreatography pancreatitis: protease inhibitors and NSAIDs in a meta-analysis. (PubMed)

confusing. Since the previous meta-analysis, several new studies have been published on this topic. To provide an updated quantitative assessment of the effectiveness of protease inhibitors and NSAIDs in preventing post-ERCP pancreatitis, we conducted a meta-analysis of randomized trials for patients at risk of post-ERCP pancreatitis. Twenty-six articles were included in this meta-analysis. Nafamostat mesilate (summary RR = 0.41; 95 %CI 0.28-0.59; n = 4 studies) and NSAIDs (summary RR = 0.58; 95 %CI (...) Pharmacologic prophylaxis of post-endoscopic retrograde cholangiopancreatography pancreatitis: protease inhibitors and NSAIDs in a meta-analysis. Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis is the most frequent complication of ERCP. Several meta-analyses have examined the effects of protease inhibitors (gabexate mesilate, ulinastatin, and nafamostat mesilate) and non-steroidal anti-inflammatory drugs (NSAIDs) on post-ERCP pancreatitis, but the results have been

2014 Journal of gastroenterology

157. NSAIDs for Pain After Ankle Fracture Surgery

related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: NSAID cohort Patients who have had surgical management of ankle fracture will be given a standing regimen (scheduled doses) of 500 mg naproxen twice a day and will have received one intraoperative dose of ketorolac. Patients will have a prescription for opioids for breakthrough pain. Drug: Naproxen Standing regimen of naproxen in experimental group to reduce need for narcotic to control pain Other (...) NSAIDs for Pain After Ankle Fracture Surgery NSAIDs for Pain After Ankle Fracture Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. NSAIDs for Pain After Ankle Fracture Surgery The safety

2014 Clinical Trials

158. The Effect of NSAID Use in the Acute Phase of Skeletally Immature Bone Healing: A Prospective Study

Actual Study Start Date : January 2014 Actual Primary Completion Date : November 2016 Actual Study Completion Date : November 2016 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Acetaminophen control group Drug: Acetaminophen acetaminophen for pain control with dose and frequency of 10-15mg/kg/dose, Maximum dose 1000mg. Maximum amount per day: 75mg/kg (not to exceed 4g/day). Other Name: Tylenol NSAID (...) The Effect of NSAID Use in the Acute Phase of Skeletally Immature Bone Healing: A Prospective Study The Effect of NSAID Use in the Acute Phase of Skeletally Immature Bone Healing: A Prospective Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2014 Clinical Trials

159. TB-IRIS NSAID Cox-2 Inhibitor Prevention Trial

Randomized Placebo Controlled Trial for Prevention of Tuberculosis-Immune Reconstitution Inflammatory Syndrome With Non-Steroid Anti-Inflammatory Drugs (NSAIDs) in HIV-Infected Adults Study Start Date : April 2014 Estimated Primary Completion Date : April 2015 Study Completion Date : April 2015 Resource links provided by the National Library of Medicine related topics: available for: resources: Arms and Interventions Go to Arm Intervention/treatment Placebo Comparator: Placebo 7.5 mg daily for 8 weeks (...) TB-IRIS NSAID Cox-2 Inhibitor Prevention Trial TB-IRIS NSAID Cox-2 Inhibitor Prevention Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. TB-IRIS NSAID Cox-2 Inhibitor Prevention Trial The safety

2014 Clinical Trials

160. Safety and Efficacy of Meloxicam Compared to Other Nonsteroidal Antiinflammatory Drugs (NSAIDs) in an Observational Cohort Study of Patients With Rheumatoid Arthritis, Osteoarthritis, Lumbago, Scapulohumeral Periarthritis, Neck, Shoulder and Arm Syndrome

Resource links provided by the National Library of Medicine related topics: related topics: available for: Groups and Cohorts Go to Group/Cohort Intervention/treatment Meloxicam Drug: Meloxicam Other NSAIDs Drug: Other Non Steroidal Anti-Inflammatory Drugs (NSAIDs) except etodolac Outcome Measures Go to Primary Outcome Measures : Incidence for adverse event of gastrointestinal disorder [ Time Frame: up to 6 months ] Secondary Outcome Measures : Incidence for adverse drug reaction of gastrointestinal (...) Safety and Efficacy of Meloxicam Compared to Other Nonsteroidal Antiinflammatory Drugs (NSAIDs) in an Observational Cohort Study of Patients With Rheumatoid Arthritis, Osteoarthritis, Lumbago, Scapulohumeral Periarthritis, Neck, Shoulder and Arm Syndrome Safety and Efficacy of Meloxicam Compared to Other Nonsteroidal Antiinflammatory Drugs (NSAIDs) in an Observational Cohort Study of Patients With Rheumatoid Arthritis, Osteoarthritis, Lumbago, Scapulohumeral Periarthritis, Neck, Shoulder

2014 Clinical Trials

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