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Topical NSAID

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121. NSAIDs for Pain After Ankle Fracture Surgery

of this study is to investigate if it is possible to decrease opioid consumption in patients undergoing ankle fracture surgery by providing scheduled doses of nonsteroidal inflammatory drugs (NSAIDs). This is a prospective, randomized, double-blinded, placebo controlled study with two groups of patients: one getting NSAIDs to take at regularly scheduled times plus a traditional prescription for opioid medication and one receiving the traditional prescription for opioid medication and a placebo. Patients (...) Investigator: Ariel T. Goldman, MD Northwell Health More Information Go to Layout table for additonal information Responsible Party: Northwell Health ClinicalTrials.gov Identifier: Other Study ID Numbers: 13-391A First Posted: November 4, 2014 Last Update Posted: December 18, 2015 Last Verified: December 2015 Additional relevant MeSH terms: Layout table for MeSH terms Fractures, Bone Ankle Fractures Fractures, Closed Wounds and Injuries Naproxen Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non

2014 Clinical Trials

122. Steroid Aromatase Inhibitors Versus Progestogens for nSAID-resistanced Late Stage Breast Cancer

: Observational Estimated Enrollment : 80 participants Observational Model: Case Control Time Perspective: Prospective Official Title: A Randomized Study of Steroid Aromatase Inhibitors Versus Progestogens for Non-Steroid Aromatase Inhibitor-resistanced Late Stage Breast Cancer Study Start Date : April 2014 Estimated Primary Completion Date : November 2016 Estimated Study Completion Date : December 2016 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Group (...) score must be 0-2 Drug resistant about Non-Steroid Aromatase Inhibitors Exclusion Criteria: Not suitable for endocrine therapy Have receive the standard Steroid Aromatase Inhibitors treatment Severe hepatic dysfunction Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier

2014 Clinical Trials

123. Efficacy and safety of loxoprofen sodium topical patch for the treatment of pain in patients with minor acute traumatic limb injuries in Brazil: a randomized, double-blind, noninferiority trial Full Text available with Trip Pro

Efficacy and safety of loxoprofen sodium topical patch for the treatment of pain in patients with minor acute traumatic limb injuries in Brazil: a randomized, double-blind, noninferiority trial Posttraumatic injury pain is commonly treated with oral nonsteroidal anti-inflammatory drugs. However, oral nonsteroidal anti-inflammatory drugs cause several adverse events, with topical formulations arising as an important alternative. Therefore, we aimed at evaluating the efficacy and safety

2019 EvidenceUpdates

124. Topical non-steroidal anti-inflammatory agents for diabetic cystoid macular oedema. (Abstract)

spontaneously, or fluctuate for months, before causing loss of vision. If left untreated or undiagnosed, progression of CMO may lead to permanent visual loss.It has been noted that patients with diabetic retinopathy have elevated inflammatory markers, and therefore it is likely that inflammation aids in the progression of vascular disease in these patients. Several topical non-steroidal anti-inflammatory drugs (NSAIDs) such as ketorolac 0.5%, bromfenac 0.09%, and nepafenac 0.1%, have therefore also been (...) used topically to treat chronic diabetic CMO. Hence this review was conducted to find out the effects of topical NSAIDs in diabetic CMO.To assess the effects of topical non-steroidal anti-inflammatory drugs (NSAIDs) for diabetic cystoid macular oedema (CMO).We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (2014, Issue 12), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to January 2015

2015 Cochrane

125. A single dose of a non-steroidal anti-inflammatory drug (NSAID) prevents severe pain after ureteric stent removal: a prospective, randomised, double-blind, placebo-controlled trial. (Abstract)

A single dose of a non-steroidal anti-inflammatory drug (NSAID) prevents severe pain after ureteric stent removal: a prospective, randomised, double-blind, placebo-controlled trial. 23759014 2013 08 15 2013 06 13 1464-410X 112 1 2013 Jul BJU international BJU Int. A single dose of a non-steroidal anti-inflammatory drug (NSAID) prevents severe pain after ureteric stent removal: a prospective, randomised, double-blind, placebo-controlled trial. E1-2 10.1111/bju.12234_2 Garg Manish M Singh (...) Vishwajeet V Sankhwar Satya Narayan SN eng Letter England BJU Int 100886721 1464-4096 0 Anti-Inflammatory Agents, Non-Steroidal IM Anti-Inflammatory Agents, Non-Steroidal administration & dosage therapeutic use Device Removal adverse effects Dose-Response Relationship, Drug Double-Blind Method Humans Pain, Postoperative drug therapy etiology Prospective Studies Randomized Controlled Trials as Topic methods Stents Ureter surgery Ureteral Diseases surgery 2013 6 14 6 0 2013 6 14 6 0 2013 8 16 6 0 ppublish

2013 BJU international Controlled trial quality: predicted high

126. NSAID Drug Interaction Study

to evaluate the potential pharmacokinetic (PK) effects of non-steroidal anti-inflammatory drugs on lesinurad and leinurad on the non-steroidal anti-inflammatory drugs. Condition or disease Intervention/treatment Phase Gout Drug: lesinurad 400 mg Drug: naproxen 250 mg Drug: indomethacin 25 mg Phase 1 Detailed Description: Naproxen and indomethacin are non-steroidal anti-inflammatory drugs (NSAIDs) used both prophylactically for the prevention of, and as a treatment for, acute gout flares. RDEA594-126 (...) Indomethacin Lesinurad Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anti-Inflammatory Agents Antirheumatic Agents Gout Suppressants Cyclooxygenase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Tocolytic Agents Reproductive Control Agents Uricosuric Agents Renal Agents

2013 Clinical Trials

127. East-West Collaboration Treatment Using Bee Venom Acupuncture and NSAIDs for Chronic Cervicalgia

between conventional and complementary alternative medical treatment bee venom acupuncture NSAIDs Additional relevant MeSH terms: Layout table for MeSH terms Neck Pain Pain Neurologic Manifestations Signs and Symptoms Loxoprofen Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anti-Inflammatory Agents Antirheumatic Agents (...) with chronic cervicalgia Condition or disease Intervention/treatment Phase Chronic Non-specific, Uncomplicated Neck Pain Procedure: Bee Venom Acupuncture Drug: Loxoprofen Phase 2 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 60 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Outcomes Assessor) Primary Purpose: Treatment Official Title: Clinical Research on the Efficacy and Safety of East

2013 Clinical Trials

128. NSAID Treatment in Knee Osteoarthritis

by Luca Gallelli, University of Cantanzaro: Knee Osteoarthritis Additional relevant MeSH terms: Layout table for MeSH terms Osteoarthritis Osteoarthritis, Knee Arthritis Joint Diseases Musculoskeletal Diseases Rheumatic Diseases Ibuprofen Celecoxib Diclofenac Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anti-Inflammatory Agents Antirheumatic Agents Cyclooxygenase Inhibitors Enzyme (...) play a role in pain perception during osteoarthritis (OA).Local inflammation (which involves production of pro-inflammatory cytokines such as interleukin (IL) 4 TNF-alpha, IL-6 and IL-8) is considered to be a major source of pain. Certain therapies that specifically interfere with the expression or actions of pro-inflammatory cytokines have been explored. NSAIDs have analgesic, antipyretic and anti-inflammatory properties and are extensively prescribed for several musculoskeletal disorders. Indeed

2013 Clinical Trials

129. Cardiovascular Risk of NSAIDs: Time to Translate Knowledge into Practice. Full Text available with Trip Pro

Agents, Non-Steroidal 0 Drugs, Essential IM PLoS Med. 2013;10(2):e1001388 23424288 Anti-Inflammatory Agents, Non-Steroidal adverse effects economics Cardiovascular Diseases chemically induced Commerce economics Developed Countries economics Developing Countries economics Drug Costs Drug Industry economics Drugs, Essential adverse effects economics Humans Pharmacopoeias as Topic 2013 2 21 6 0 2013 2 21 6 0 2013 7 17 6 0 ppublish 23424289 10.1371/journal.pmed.1001389 PMEDICINE-D-12-03788 PMC3570557 N (...) Cardiovascular Risk of NSAIDs: Time to Translate Knowledge into Practice. 23424289 2013 07 15 2018 12 02 1549-1676 10 2 2013 PLoS medicine PLoS Med. Cardiovascular risk of NSAIDs: time to translate knowledge into practice. e1001389 10.1371/journal.pmed.1001389 Reddy K Srinath KS Public Health Foundation of India, ISID Campus, Vasant Kunj, New Delhi, India. ksrinath.reddy@phfi.org Roy Ambuj A eng Journal Article Comment 2013 02 12 United States PLoS Med 101231360 1549-1277 0 Anti-Inflammatory

2013 PLoS medicine

130. Discontinuing NSAIDs

problem. It is the number one cause of lower extremity disability and has significant deleterious effects on quality of life. While there are numerous therapies available for knee OA, most have limited efficacy. Of particular concern, is the widespread use of nonsteroidal anti-inflammatory drugs (NSAIDs) for this disorder. Veterans, as a group, are at high risk for both gastrointestinal and cardiovascular NSAID-induced complications. In this study the investigators propose to examine whether replacing (...) Osteoarthritis Drug: Meloxicam 15 mg po QD Behavioral: Cognitive Behavioral Therapy Phase 2 Detailed Description: Knee osteoarthritis (OA) is a major cause of disability among Veterans and is the primary indication of knee replacement in the VA. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly prescribed medications for knee OA. Though short-term studies have demonstrated that NSAIDs are more effective than placebo and acetaminophen, there are no long-term data supporting their use

2013 Clinical Trials

131. Topical interferon alpha 2b in the treatment of refractory pseudophakic cystoid macular edema Full Text available with Trip Pro

Topical interferon alpha 2b in the treatment of refractory pseudophakic cystoid macular edema To report the efficacy and safety of interferon alpha 2b in the treatment of pseudophakic cystoid macular edema resistant to conventional therapy.A 64-year-old patient presented with pseudophakic cystoid macular edema in her left eye, which developed two months after an uncomplicated cataract surgery and was resistant to multiple topical NSAIDs and multiple intravitreal bevacizumab injections over (...) the course of nine months. She also developed side effects to oral acetazolamide and intravitreal triamcinolone injection; a skin rash and a rise in intraocular pressure (34 mmHg), respectively. She was subsequently started on topical interferon alpha 2b (1 MIU/ml) four times a day nine months after developing pseudophakic cystoid macular edema. Cystoid macular edema improved significantly in four weeks and completely resolved after twelve weeks. Her vision improved from 20/100 before starting treatment

2018 American journal of ophthalmology case reports

132. Compounded Diclofenac Cream for Topical Anti-Inflammatory Treatment

). Available from: http://www.ncbi.nlm.nih.gov/books/NBK53955/ Systematic Reviews and Meta-analyses – Topical Diclofenac 3. BMJ Clinical Evidence [Internet]. London: BMJ Publishing Group Limited. Non-steroidal anti-inflammatory drugs (NSAIDs) (topical); 2014 Oct 14 [cited 2015 Apr 28]. Available from: http://clinicalevidence.bmj.com/x/systematic-review/0812/intervention/sr- 0812-i14.html 4. Derry S, Moore RA, Rabbie R. Topical NSAIDs for chronic musculoskeletal pain in adults. Cochrane Database Syst Rev (...) ://www.healthquality.va.gov/guidelines/cd/oa/index.asp Compounded Diclofenac Cream for Topical Anti-Inflammatory Treatment 5 See: D1: Acetaminophen and Non-steroidal Anti-inflammmatory Drugs, pages 30 to 31 8. Osteoarthritis: care and management in adults [Internet]. London: National Institute for Health and Care Excellence; 2014 Feb. [cited 2015 Apr 28]. (NICE Guidelines CG177). Available from: http://www.nice.org.uk/guidance/cg177/chapter/1-recommendations%20- %20pharmacological-management See: Topical treatments

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

133. COX2 Selective NSAID

COX2 Selective NSAID COX2 Selective NSAID Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 COX2 Selective NSAID COX2 Selective NSAID (...) Aka: COX2 Selective NSAID , COX2 Inhibitor , COX-2 Inhibitor From Related Chapters II. Class in the COX2 selective class III. Agents COX-2 Inhibitors ( ) ( ) - withdrawn from U.S. market in 2004 Valdecoxib (Bextra) - withdrawn from U.S. market in 2005 s which favor COX-2 (alternatives to COX-2) Etodolac (Lodine) Nabumetone (Relafen) Meloxicam (Mobic) However, higher risk of IV. Advantages Less gastrointestinal adverse effects than other s See Cost may not outweigh benefits to prevent 1 : 200

2015 FP Notebook

134. NSAID Renal Adverse Effects

Necrosis VI. Management: Practice Guidelines for NSAID use in the elderly Establish a definitive treatment diagnosis Inflammatory condition (e.g. ) indicated offers no advantage regarding nephrotoxicity Non-Inflammatory condition alternative medication (e.g. ) Perform baseline and repeat q3-12 months See s for lab monitoring Consider screening for Choose with high benefit to risk ratio (e.g. Sulindac) Good efficacy Lower renal toxicity Avoid the most S most commonly associated with nephrotoxicity (...) NSAID Renal Adverse Effects NSAID Renal Adverse Effects Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 NSAID Renal Adverse Effects

2015 FP Notebook

135. NSAID Gastrointestinal Adverse Effects

62473009 English NSAID-associated gastropathy (disorder) , Non-steroidal anti-inflammatory drug-associated gastropathy , Non-steroidal anti-inflammatory drug (NSAID)-associated gastropathy , Non-steroidal anti-inflammatory drug-associated gastropathy (disorder) , Non-steroidal anti-inflammatory drug (NSAID)-associated gastropathy (disorder) , NSAID-associated gastropathy , Nonsteroidal anti-inflammatory drug-associated gastropathy Spanish gastropatía asociada a antinflamatorios no esteroides (trastorno (...) Gastrointestinal Adverse Effects NSAID Gastrointestinal Adverse Effects Aka: NSAID Gastrointestinal Adverse Effects II. Risk Factors: NSAID related GI adverse effects Age over 60 years (decreased GI protection) history Concurrent use Concurrent oral ( , ) High dose III. Risk Factors: Relative Risks of GI adverse effects Lowest Risk: s (Selective) ( ) ( ) Low Risk (Non-Selective s) ( 1.0 to 2.7) Fenoprofen or Nalfon ( 1.6) ( 1.6) Diclofenac or Voltaren ( 1.8 to 4.0) Sulindac or Clinoril ( 2.1) Nabumetone

2015 FP Notebook

136. Ocular NSAID

Nonsteroidal Antiinflammatory Drug , Ketorolac Ophthalmic , Acular , Diclofenac Ophthalmic , Voltaren Ophthalmic II. Indications III. Preparations 0.5% (Acular) 1 drop qid x7d Diclofenac 0.1% (Voltaren) 1 drop qid Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Ocular NSAID." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Cost: Medications acular (on 1/1/2017 (...) at ) ACULAR 0.5% EYE DROPS Generic $1.51 per ml ACULAR LS 0.4% OPHTH SOL Generic $9.98 per ml FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See for financial assistance information. Related Topics in Pharmacology About FPnotebook.com

2015 FP Notebook

137. Assessment of NSAID-treated Patients Adherence to Co-prescribed Proton Pump Inhibitor (PPI)

Study on NSAIDs Treated Patients With Osteoarthritis, Rheumatoid Arthritis and Ankylosing Spondylitis: Assessment of Patient Adherence to PPI Treatment Study Start Date : March 2012 Actual Primary Completion Date : May 2012 Actual Study Completion Date : May 2012 Resource links provided by the National Library of Medicine related topics: related topics: resources: Groups and Cohorts Go to Group/Cohort 1 Patients with Osteoarthritis, Rheumatoid Arthritis and Ankylosing Spondylitis, 18 years or older (...) Assessment of NSAID-treated Patients Adherence to Co-prescribed Proton Pump Inhibitor (PPI) Assessment of NSAID-treated Patients Adherence to Co-prescribed Proton Pump Inhibitor (PPI) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2012 Clinical Trials

138. NSAIDs With Morphine-PCA Compared to Epidural Analgesia in Thoracotomy Pain

NSAID PCA TEA chronic Additional relevant MeSH terms: Layout table for MeSH terms Pain, Postoperative Postoperative Complications Pathologic Processes Pain Neurologic Manifestations Signs and Symptoms Bupivacaine Morphine Diclofenac Parecoxib Valdecoxib Anesthetics, Local Anesthetics Central Nervous System Depressants Physiological Effects of Drugs Sensory System Agents Peripheral Nervous System Agents Analgesics, Opioid Narcotics Analgesics Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non (...) . Condition or disease Intervention/treatment Phase Postoperative Pain Drug: Diclofenac Drug: parecoxib/ valdecoxib Device: patient controlled epidural analgesia Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 30 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Triple (Participant, Care Provider, Investigator) Primary Purpose: Treatment Official Title: NSAID With IV-PCA Morphine

2012 Clinical Trials

139. Clinical Research of the Prognostic Influence of NSAIDS's Anti-inflammatory Effect on Senior Patients With Hip Fracture

effects on organs, and the recovery could be improved. The investigators hypothesis on the basic research: the anti-inflammatory function of non steroidal antiinflammatory drugs (NSAIDs) can inhibit the inflammatory level of elderly hip fracture, so as to improve the recovery level and reduce the complicating disease and mortality. The investigators designed a clinic study to research NSAIDS' effects on inflammatory level and prognosis of elderly hip fracture. Condition or disease Intervention (...) Wounds and Injuries Femoral Fractures Hip Injuries Leg Injuries Acetaminophen Celecoxib Acetaminophen, hydrocodone drug combination Oxycodone Anti-Inflammatory Agents Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Antipyretics Anti-Inflammatory Agents, Non-Steroidal Antirheumatic Agents Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Analgesics, Opioid

2012 Clinical Trials

140. NSAID Effects on Clinical and Imaging Breast Biomarkers

Inflammation Pathologic Processes Aromatase Inhibitors Sulindac Steroid Synthesis Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Estrogen Antagonists Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Physiological Effects of Drugs Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Anti-Inflammatory Agents Antirheumatic Agents Antineoplastic Agents Cyclooxygenase Inhibitors (...) information Study Type : Interventional (Clinical Trial) Actual Enrollment : 80 participants Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: NSAID Effects on Clinical and Imaging Breast Biomarkers Study Start Date : December 2012 Estimated Primary Completion Date : June 2019 Estimated Study Completion Date : June 2019 Resource links provided by the National Library of Medicine related topics: related topics: available

2012 Clinical Trials

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