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Topical NSAID

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101. NSAID Treatment of Patients With Osteoarthritis

Update Posted: March 27, 2018 Last Verified: March 2018 Additional relevant MeSH terms: Layout table for MeSH terms Osteoarthritis Osteoarthritis, Knee Arthritis Joint Diseases Musculoskeletal Diseases Rheumatic Diseases Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anti-Inflammatory Agents Antirheumatic Agents (...) Purpose: Diagnostic Official Title: BEVAR: Patientspecifik Behandling Ved Artrose - Et "Proof-of-concept"- Kvalitetssikringsstudie Study Start Date : January 2016 Actual Primary Completion Date : January 2018 Actual Study Completion Date : February 1, 2018 Resource links provided by the National Library of Medicine related topics: related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: NSAID treatment 8 weeks of NSAID treatment Drug: NSAID NSAIDs are among the most common

2016 Clinical Trials

102. Effects of a Cyclic NSAID Regimen on Levels of GCF PGE-E2 and IL-1beta

Alptekin, Baskent University Study Details Study Description Go to Brief Summary: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for inflammation control and pain relief. However, while adjunct use of NSAIDs is avoided for periodontal therapy because of related side effects, cyclic administration of NSAIDs may reduce or eliminate these effects. The investigators evaluated the effect of a cyclic diclofenac potassium regimen on clinical parameters and levels of prostaglandin E2 (PGE2 (...) and GCF sample collections were made at baseline, 2, 4 and 6 months. GCF levels of PGE2 and IL1-1beta were determined using EIA and ELISA kits, respectively. Condition or disease Intervention/treatment Phase Non-steroidal Anti-inflammatory Poisoning Drug: cataflam (diclofenac potassium) Drug: placebo Phase 2 Detailed Description: Study Design This study utilized a randomized, controlled, double-blind, parallel-group design to investigate the 6-month effect of a cyclic regimen of diclofenac potassium

2016 Clinical Trials

103. NSAID Use in Postpartum Hypertensive Women

to Share IPD: No Layout table for additional information Studies a U.S. FDA-regulated Drug Product: Yes Studies a U.S. FDA-regulated Device Product: No Product Manufactured in and Exported from the U.S.: No Additional relevant MeSH terms: Layout table for MeSH terms Acetaminophen Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Antipyretics Anti-Inflammatory Agents Antirheumatic Agents (...) pressure. Condition or disease Intervention/treatment Phase Hypertension Drug: Acetaminophen Drug: NSAID Phase 4 Detailed Description: The patients who have a vaginal delivery and have the diagnosis of hypertension in pregnancy will be randomized to either Ibuprofen use or acetaminophen use during the postpartum period. Standard blood pressure monitoring in the postpartum period will be followed to help determine if there is a significant rise in the women who use NSAIDS in the postpartum period versus

2016 Clinical Trials

104. NSAIDs Added to Anti-TNF Therapy Versus Anti-TNF Therapy Alone on Progression of Structural Damage in Ankylosing Spondylitis

: Active, not recruiting First Posted : May 2, 2016 Last Update Posted : December 19, 2018 Sponsor: Charite University, Berlin, Germany Information provided by (Responsible Party): Denis Poddubnyy, Charite University, Berlin, Germany Study Details Study Description Go to Brief Summary: To evaluate the impact of treatment with a non-steroidal anti-inflammatory drug (NSAID) - Celecoxib - when added to anti-tumour necrosis factor (TNF) therapy - Golimumab - as compared to anti-TNF therapy (Golimumab (...) ) alone on progression of structural damage in the spine over two years in patients with ankylosing spondylitis (AS). Condition or disease Intervention/treatment Phase Ankylosing Spondylitis Biological: Golimumab Drug: Celecoxib Phase 4 Detailed Description: The aim of the proposed trial is to evaluate the efficacy of combined treatment with a non-steroidal anti-inflammatory drug (NSAID) added to anti-tumour necrosis factor (TNF) therapy as compared to anti-TNF therapy alone on progression

2016 Clinical Trials

105. Impact of a Free Distribution of Paracetamol to Osteoarthritic Patients on Non-steroidal Anti-inflammatory Drugs (NSAID) and Proton Pump Inhibitors (PPI) Prescription

Impact of a Free Distribution of Paracetamol to Osteoarthritic Patients on Non-steroidal Anti-inflammatory Drugs (NSAID) and Proton Pump Inhibitors (PPI) Prescription Impact of a Free Distribution of Paracetamol to Osteoarthritic Patients on Non-steroidal Anti-inflammatory Drugs (NSAID) and Proton Pump Inhibitors (PPI) Prescription - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms (...) x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Impact of a Free Distribution of Paracetamol to Osteoarthritic Patients on Non-steroidal Anti-inflammatory Drugs (NSAID) and Proton Pump Inhibitors (PPI) Prescription The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been

2016 Clinical Trials

106. Proof-of-concept Study of NSAID Hydrogel Patch in Treatment of Acute Pain

for any purpose within 7 days of Screening. Subject has taken flurbiprofen or naproxen within 24 hours of Screening. Ankle sprain is treated prior to Screening by ultrasound, physical therapy, or acupuncture. Subject has used immunomodulators or immunosuppressive therapies (e.g., interferon, oral or parenteral corticosteroids, and cytotoxic drugs) within 4 weeks prior to randomization. Subject has used any medicated topical agents (e.g., medicated creams or lotions) on the affected ankle within 7 days (...) prior to Screening. Subject is currently using any other medications that, in the opinion of the Investigator, may exacerbate or mask the anticipated side effects of NSAIDs or interfere with the Investigator's ability to monitor for them (e.g., blood thinners or proton-pump inhibitors). Subject has non-intact or damaged skin in the area to be treated (e.g., eczema, psoriasis, exudative dermatitis, infected lesion, burn, or wound). Subject has a history of ulcers, GI bleeding, hypertension, edema

2016 Clinical Trials

107. Post-op Acetaminophen vs NSAID Use on Lumbar Spinal Fusion Outcomes

Description: Given the potential for non-steroidal anti inflammatory drugs (NSAIDs) and acetaminophen to decrease opioid requirements following spine surgery, the investigators propose a prospective, randomized, double-blinded clinical trial comparing the efficacy of intravenous (IV) acetaminophen (Group A) or IV ketorolac (Group K) versus placebo (Group P). The impact of treatment on perioperative opioid use, opioid-related complications, functional outcomes and rates of pseudarthrosis following 1 or 2 (...) Osteoarthritis, Spine Arthritis Joint Diseases Musculoskeletal Diseases Rheumatic Diseases Spinal Diseases Bone Diseases Spondylarthritis Spondylitis Acetaminophen Ketorolac Ketorolac Tromethamine Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Antipyretics Anti-Inflammatory Agents Antirheumatic Agents Cyclooxygenase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action

2016 Clinical Trials

108. Do NSAIDS or Executing Exercise Decrease Local Erythema, Site Swelling & Pain After INoculation

medical exclusion for ibuprofen. Have a history of stroke or coronary artery disease, such as uncontrolled high blood pressure or abnormal heart beat. Has taken any topical or oral pain medications from the following medication classes in the past 24 hours prior to the start of the study: oral acetaminophen, opioids, tramadol, nonsteroidal anti-inflammatory drug (NSAID) or acetylsalicylic acid (ASA) or topical pain relievers or counterirritants of menthol, methyl salicylate, camphor menthols (...) Update Posted: February 18, 2019 Last Verified: February 2019 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: No Additional relevant MeSH terms: Layout table for MeSH terms Erythema Skin Diseases Skin Manifestations Signs and Symptoms Vaccines Ibuprofen Immunologic Factors Physiological Effects of Drugs Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Anti-Inflammatory Agents Antirheumatic Agents

2016 Clinical Trials

109. NSAID vs. Narcotics

Intervention/treatment Multimodal Analgesia Nonsteroidal Anti-inflammatory Drugs Drug: Ibuprofen 600 mg Drug: standard oxycodone/acetaminophen Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 77 participants Observational Model: Case-Control Time Perspective: Prospective Official Title: Multimodal Analgesia With NSAID vs. Narcotics Alone for Post-operative Meniscectomy: A Prospective Observational Study Actual Study Start Date : September 1, 2016 Actual (...) terms: Layout table for MeSH terms Acetaminophen Ibuprofen Acetaminophen, hydrocodone drug combination Oxycodone Narcotics Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Antipyretics Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents Antirheumatic Agents Cyclooxygenase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Analgesics, Opioid Central Nervous System Depressants

2016 Clinical Trials

110. Exposure to NSAIDs (Non Steroidal Anti-Inflammatory Drugs) and Severity of Community-acquired Bacterial Infections

Exposure to NSAIDs (Non Steroidal Anti-Inflammatory Drugs) and Severity of Community-acquired Bacterial Infections Exposure to NSAIDs (Non Steroidal Anti-Inflammatory Drugs) and Severity of Community-acquired Bacterial Infections - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Exposure to NSAIDs (Non Steroidal Anti-Inflammatory Drugs) and Severity of Community-acquired Bacterial Infections (ANAIG) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2016 Clinical Trials

111. Cost effectiveness of etoricoxib versus celecoxib and non-selective NSAIDs in the treatment of ankylosing spondylitis

the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study evaluated the cost-effectiveness of etoricoxib compared with celecoxib, diclofenac, and naproxen for patients with ankylosing spondylitis, who required routine non-steroidal anti-inflammatory drug (NSAID) treatment. The authors concluded that their economic (...) with ankylosing spondylitis, who required routine non-steroidal anti-inflammatory drug (NSAID) treatment. Interventions The first-line treatment for ankylosing spondylitis was non-steroidal anti-inflammatory drugs. The interventions were etoricoxib, a cyclooxygenase-2 selective inhibitor, 90mg per day (the anticipated defined daily dose), celecoxib (200 and 400mg per day), diclofenac (150mg per day), and naproxen (1g per day). Location/setting UK/primary care. Methods Analytical approach: A comprehensive

2010 NHS Economic Evaluation Database.

112. Ex vivo corneal epithelial wound healing following exposure to ophthalmic nonsteroidal anti-inflammatory drugs (Full text)

Ex vivo corneal epithelial wound healing following exposure to ophthalmic nonsteroidal anti-inflammatory drugs Ketorolac 0.45% is a new formulation of topical ketorolac in which preservative (benzalkonium chloride, BAK) was removed and carboxymethylcellulose (CMC) was added to improve tolerability and reduce dosing frequency. This study compared the effects of ketorolac 0.45% on corneal wound healing to prior ketorolac formulations (0.4% and 0.5%), bromfenac 0.09%, and nepafenac 0.1%.Two (...) parallel-group comparisons were performed in series. A 5-mm central epithelial wound was made in fresh porcine corneas. After 24 hours in minimum essential medium (MEM), corneas were incubated for 10 minutes with study drugs, Triton X-100 1% (positive control), or MEM (negative control), followed by 24 hours in MEM. The remaining wound area was stained, photographed, and quantified (pixels). Study 1 compared ketorolac 0.45% to ketorolac 0.4% and ketorolac 0.5%. Study 2 compared ketorolac 0.45

2011 Clinical ophthalmology (Auckland, N.Z.) PubMed abstract

113. Combination of topical NSAIDs and anti-VEGF for age-related macular degeneration treatment

Combination of topical NSAIDs and anti-VEGF for age-related macular degeneration treatment Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address (...) subgroup analyses will be performed. If one or more subgroup analyses cannot be performed due to insufficient data, the p-value will be adjusted accordingly. ">Other Subgroup analysis or meta-regression are used to explore between-study heterogeneity and can provide insight into the relationship between study characteristics (e.g. species, sex or drug class or dose) and effect size. They should be considered hypothesis-generating. Ideally, a threshold describing the number of studies per subgroup

2016 PROSPERO

114. Topical NSAID

and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See for financial assistance information. Ontology: Diclofenac Topical Product (C0358504) Concepts Clinical Drug ( T200 ) SnomedCT 349350007 English Topical diclofenac , diclofenac topical , Diclofenac Topical Product , Topical form diclofenac (product) , Topical form diclofenac , Topical diclofenac (product) , Topical diclofenac (substance) Spanish (...) Topical NSAID Topical NSAID Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Topical NSAID Topical NSAID Aka: Topical NSAID

2016 FP Notebook

115. Topical NSAID formulations. (Full text)

Topical NSAID formulations. This article reviews topical nonsteroidal anti-inflammatory drug (NSAID) formulations available in the United States, including advantages and disadvantages, therapeutic usefulness, adverse effects, and formulation considerations.In the United States, several topical NSAID products are approved to treat painful conditions including diclofenac sodium 1% gel (Voltaren Gel®; Endo Pharmaceuticals), diclofenac sodium topical solution 1.5% w/w in 45.5% dimethyl sulfoxide (...) (PENNSAID®; Mallinckrodt, Inc.), and diclofenac epolamine 1.3% (Flector Patch®; Alpharma Pharmaceuticals LLC, a subsidiary of Pfizer, Inc.). Recent studies suggest topical diclofenac preparations are effective for osteoarthritis pain and suggest the efficacy of topical formulations is similar to that achieved with oral NSAID formulations. All NSAID formulations contain the same boxed warnings regarding cardiovascular and renal toxicity; however, topical NSAIDs are proposed to have a more favorable

2013 Pain Medicine PubMed abstract

116. NSAID Pretreatment Inhibits Prostaglandin Release in Femtosecond Laser-Assisted Cataract Surgery. (Abstract)

NSAID Pretreatment Inhibits Prostaglandin Release in Femtosecond Laser-Assisted Cataract Surgery. To investigate whether short-term nonsteroidal anti-inflammatory drug (NSAID) pretreatment on the day of surgery inhibits prostaglandin release. Previous studies detected elevated prostaglandin levels after femtosecond laser treatment and identified them as a potential mediator for laser-induced miosis.Patients underwent either image-guided femtosecond laser cataract surgery or conventional (...) cataract surgery (n = 75). Half of the eyes per group received topical NSAID treatment on the day of surgery. Aqueous humor was collected from all patients. ELISA measurements were performed to detect aqueous humor prostaglandin levels.Femtosecond laser cataract surgery led to higher prostaglandin levels than conventional cataract surgery (P = .007). In both groups, NSAID pretreatment led to reduced prostaglandin release. In the femtosecond laser group, patients pretreated with NSAIDs had significantly

2015 Journal of Refractive Surgery Controlled trial quality: uncertain

117. Effect of PPARγ2 Polymorphism and NSAIDs on Acute Alcohol-induced Changes in Serum Estrogens Among Post-menopausal Women

Ibuprofen Estrogens Anti-Infective Agents, Local Anti-Infective Agents Central Nervous System Depressants Physiological Effects of Drugs Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Anti-Inflammatory Agents Antirheumatic Agents Cyclooxygenase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Hormones Hormones, Hormone Substitutes, and Hormone Antagonists (...) : Basic Science Official Title: Alcohol-related Breast Cancer in Postmenopausal Women - Effect of PPARG2pro12ala Polymorphism on Female Sex-hormone Levels and Interaction With Alcohol Consumption and NSAID Usage Study Start Date : September 2013 Actual Primary Completion Date : October 2014 Actual Study Completion Date : December 2015 Resource links provided by the National Library of Medicine related topics: related topics: available for: Arms and Interventions Go to Arm Intervention/treatment

2015 Clinical Trials

118. Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Risk of Acute Kidney Injury in Patients With Heart Failure

Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Risk of Acute Kidney Injury in Patients With Heart Failure Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Risk of Acute Kidney Injury in Patients With Heart Failure - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Risk of Acute Kidney Injury in Patients With Heart Failure The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02642081 Recruitment Status : Unknown Verified January 2016 by National Taiwan

2015 Clinical Trials

119. Study of FLEXISEQ® for Treatment of Osteoarthritis of the Knee in NSAID-compromised Patients

follow-up, randomised, double-blind study comparing the efficacy and tolerability of topical FLEXISEQ® with placebo for the treatment of osteoarthritis of the knee in patients contraindicated for or with clinical intolerance to NSAIDs and with OA of the knee will have a total individual treatment period of 12 weeks. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 600 participants Allocation: Randomized Intervention Model (...) : Parallel Assignment Masking: Double (Participant, Investigator) Primary Purpose: Treatment Official Title: A Randomised, Double-blind, Placebo Controlled Study of Topical FLEXISEQ® for the Treatment of Osteoarthritis of the Knee in Patients Contraindicated for or With Clinical Intolerance to NSAIDs Study Start Date : October 2015 Estimated Primary Completion Date : March 2016 Estimated Study Completion Date : October 2016 Resource links provided by the National Library of Medicine related topics

2015 Clinical Trials

120. NSAIDS Versus Opioids in Acute SER II Ankle Fractures

of an opioid analgesic combined with acetaminophen, thereby influencing pain development at central perception by the opioid analgesic and acetaminophen and a peripheral analgesic effect of acetaminophen. The exact mechanism of the peripheral effect is not known. This clinical practice disregards the positive effect of medications influencing the peripheral inflammatory response, namely nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs affect pain development by blocking the synthesis of arachidonic (...) Numbers: 656916 First Posted: February 26, 2015 Last Update Posted: July 14, 2017 Last Verified: July 2017 Additional relevant MeSH terms: Layout table for MeSH terms Fractures, Bone Ankle Fractures Wounds and Injuries Acetaminophen Ibuprofen Acetaminophen, hydrocodone drug combination Hydrocodone Oxycodone Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Antipyretics Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory

2015 Clinical Trials

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