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Topical NSAID

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81. A Study of ABT-652 in Combination With a Nonsteroidal Anti-Inflammatory Drug (NSAID) in Adults With Osteoarthritis Pain of the Knee

Recruitment Status : Completed First Posted : September 30, 2011 Last Update Posted : May 15, 2013 Sponsor: AbbVie (prior sponsor, Abbott) Information provided by (Responsible Party): AbbVie ( AbbVie (prior sponsor, Abbott) ) Study Details Study Description Go to Brief Summary: To evaluate the safety and efficacy of ABT-652 in combination with a Non-steroidal Anti-inflammatory Drug (NSAID) compared to NSAID alone in adults with osteoarthritis (OA) of the knee. Condition or disease Intervention/treatment (...) A Study of ABT-652 in Combination With a Nonsteroidal Anti-Inflammatory Drug (NSAID) in Adults With Osteoarthritis Pain of the Knee A Study of ABT-652 in Combination With a Nonsteroidal Anti-Inflammatory Drug (NSAID) in Adults With Osteoarthritis Pain of the Knee - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have

2011 Clinical Trials

82. Retrospective Review of NSAIDS in the Postpartum Period

University Study Details Study Description Go to Brief Summary: Chart review of women who have delivered an infant in a single health care system to determine if NSAID use increases blood pressures in the postpartum period. Condition or disease Intervention/treatment Post Partum Pain Other: NSAID use Detailed Description: Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common medication used for pain relief in the postpartum period in the United States. For pain relief of uterine involution (...) : 26975 First Posted: January 20, 2017 Last Update Posted: November 13, 2017 Last Verified: November 2017 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: No Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Additional relevant MeSH terms: Layout table for MeSH terms Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents

2017 Clinical Trials

83. Characterization of Non-Steroidal Anti-Inflammatory Drug (NSAID) Intake in Rheumatoid Arthritis (RA) Participants on Tocilizumab (RoACTEMRA®) Treatment

Characterization of Non-Steroidal Anti-Inflammatory Drug (NSAID) Intake in Rheumatoid Arthritis (RA) Participants on Tocilizumab (RoACTEMRA®) Treatment Characterization of Non-Steroidal Anti-Inflammatory Drug (NSAID) Intake in Rheumatoid Arthritis (RA) Participants on Tocilizumab (RoACTEMRA®) Treatment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved (...) Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Characterization of Non-Steroidal Anti-Inflammatory Drug (NSAID) Intake in Rheumatoid Arthritis (RA) Participants on Tocilizumab (RoACTEMRA®) Treatment (CONIFER) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government

2017 Clinical Trials

84. The effect of NSAIDs on spinal fusion: a cross-disciplinary review of biochemical, animal, and human studies. (Abstract)

The effect of NSAIDs on spinal fusion: a cross-disciplinary review of biochemical, animal, and human studies. Non-steroidal anti-inflammatory drugs (NSAIDs) play an important role in postoperative pain management. However, their use in the setting of spine fusion surgery setting has long been a topic of controversy. In this review we examined relevant research, including in vivo, animal, and clinical human studies, with the aim of understanding the effect of NSAIDs on spinal fusion.Systematic (...) review of study designs of all types from randomized controlled trials and meta-analyses to single-institution retrospective reviews.A search of PubMed and Embase was conducted using the keywords: "spine," "spinal fracture," NSAIDs, anti-inflammatory non-steroidal agents, bone, bone healing, fracture, fracture healing, yielding a total of 110 studies. Other 28 studies were identified by cross-referencing, resulting in total 138 studies.There is no level I evidence from human studies regarding the use

2017 European Spine Journal

85. Efficacy and safety of topical NSAIDs in the management of osteoarthritis: Evidence from real-life setting trials and surveys. (Full text)

Efficacy and safety of topical NSAIDs in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Topical non-steroidal anti-inflammatory drugs (NSAIDs) are recommended in international and national guidelines as an early treatment option for the symptomatic management of knee and hand osteoarthritis (OA), and may be used ahead of oral NSAIDs due to their superior safety profile. The European Society for Clinical and Economic Aspects of Osteoporosis (...) and Osteoarthritis (ESCEO) treatment algorithm recommends topical NSAIDs for knee OA in addition to the pharmacological background of symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) and rescue analgesia with paracetamol and non-pharmacological treatment, if the patient is still symptomatic. Topical NSAIDs have a moderate effect on pain relief, with efficacy similar to that of oral NSAIDs, with the advantage of a better risk:benefit ratio. In real-life studies, topical and oral NSAIDs demonstrate

2015 Seminars in arthritis and rheumatism PubMed abstract

86. Strong topical steroid, NSAID, and carbonic anhydrase inhibitor cocktail for treatment of cystoid macular edema (Full text)

Strong topical steroid, NSAID, and carbonic anhydrase inhibitor cocktail for treatment of cystoid macular edema To report the combination cocktail of strong steroid, non-steroidal anti-inflammatory drug (NSAID), and carbonic anhydrase inhibitor drops for treatment of cystoid macular edema.This is a retrospective case series of patients with cystoid macular edema managed with a topical combination of strong steroid (difluprednate), NSAID, and carbonic anhydrase inhibitor drops. The patients were (...) followed with optical coherence tomography and fluorescein angiography.In our six cases, resolution of the cystic edema with improvement in visual acuity was achieved with the use of a combination cocktail of drops. Leakage on fluorescein angiography and cystic edema on optical coherence tomography both responded to treatment with the topical cocktail of drops.A topical cocktail of strong steroid, NSAID, and carbonic anhydrase inhibitor drops are effective for managing cystoid macular edema. Further

2015 International medical case reports journal PubMed abstract

87. Topical NSAIDs effect on corneal sensitivity. (Full text)

Topical NSAIDs effect on corneal sensitivity. Topical nonsteroidal antiinflammatory drugs (NSAIDs) are administered topically for a variety of ophthalmologic conditions. Brand diclofenac and brand ketorolac were previously shown to have topical anesthetic effects in addition to analgesic effects. Using the same method, we measured similar anesthetic effects of the 4 currently available topical NSAIDs--generic diclofenac, generic ketorolac, brand bromfenac, and brand nepafenac.Baseline corneal (...) sensitivity was measured on 10 healthy adult volunteers with a Cochet-Bonnet esthesiometer. One drop of the agent being studied was applied to the right eye every 5 minutes for a total of 4 drops. Corneal sensitivity was measured immediately after the last topical application and every 15 minutes for 60 minutes. After a 1-week washout period, a different agent was studied until all 4 NSAIDs were evaluated.Corneal sensitivity profiles over time were similar for all NSAIDs. Corneal sensitivity decreased

2015 Cornea Controlled trial quality: uncertain PubMed abstract

88. Cochrane systematic review: Topical NSAIDs provide effective relief of acute musculoskeletal pain compared to placebo, with no increase in risk of adverse effects

Cochrane systematic review: Topical NSAIDs provide effective relief of acute musculoskeletal pain compared to placebo, with no increase in risk of adverse effects Topical NSAIDs provide effective relief of acute musculoskeletal pain compared to placebo, with no increase in risk of adverse effects | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about (...) how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Topical NSAIDs provide effective relief of acute musculoskeletal pain compared to placebo

2011 Evidence-Based Nursing

89. Comparison of NSAID Patch Given in Monotherapy and NSAID Patch in Combination With Transcutaneous Electric Nerve Stimulation, Heating Pad, or Topical Capsaicin in the Treatment of Patients With Myofascial Pain Syndrome of the Upper Trapezius: A Pilot Stud

anti-inflammatory drug (NSAID) patch given in monotherapy and NSAID patch in combination with transcutaneous electric nerve stimulation, heating pad, or topical capsaicin in the treatment of patients with MPS of the upper trapezius. Condition or disease Intervention/treatment Phase Myofascial Pain Syndrome of the Upper Trapezius Drug: NSAID patch Drug: NSAID patch + transcutaneous electric nerve stimulation Drug: NSAID patch + heating pad Drug: NSAID patch + topical capsaicin Not Applicable Study (...) Musculoskeletal Diseases Rheumatic Diseases Neuromuscular Diseases Nervous System Diseases Anti-Inflammatory Agents, Non-Steroidal Capsaicin Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anti-Inflammatory Agents Antirheumatic Agents Antipruritics Dermatologic Agents

2013 Clinical Trials

90. Ocular NSAID

Nonsteroidal Antiinflammatory Drug , Ketorolac Ophthalmic , Acular , Diclofenac Ophthalmic , Voltaren Ophthalmic II. Indications III. Preparations 0.5% (Acular) 1 drop qid x7d Diclofenac 0.1% (Voltaren) 1 drop qid Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Ocular NSAID." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Cost: Medications acular (on 1/1/2017 (...) at ) ACULAR 0.5% EYE DROPS Generic $1.51 per ml ACULAR LS 0.4% OPHTH SOL Generic $9.98 per ml FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See for financial assistance information. Related Topics in Pharmacology About FPnotebook.com

2018 FP Notebook

91. COX2 Selective NSAID

COX2 Selective NSAID COX2 Selective NSAID Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 COX2 Selective NSAID COX2 Selective NSAID (...) Aka: COX2 Selective NSAID , COX2 Inhibitor , COX-2 Inhibitor From Related Chapters II. Class in the COX2 selective class III. Agents COX-2 Inhibitors ( ) ( ) - withdrawn from U.S. market in 2004 Valdecoxib (Bextra) - withdrawn from U.S. market in 2005 s which favor COX-2 (alternatives to COX-2) Etodolac (Lodine) Nabumetone (Relafen) Meloxicam (Mobic) However, higher risk of IV. Advantages Less gastrointestinal adverse effects than other s See Cost may not outweigh benefits to prevent 1 : 200

2018 FP Notebook

92. NSAID Renal Adverse Effects

Necrosis VI. Management: Practice Guidelines for NSAID use in the elderly Establish a definitive treatment diagnosis Inflammatory condition (e.g. ) indicated offers no advantage regarding nephrotoxicity Non-Inflammatory condition alternative medication (e.g. ) Perform baseline and repeat q3-12 months See s for lab monitoring Consider screening for Choose with high benefit to risk ratio (e.g. Sulindac) Good efficacy Lower renal toxicity Avoid the most S most commonly associated with nephrotoxicity (...) NSAID Renal Adverse Effects NSAID Renal Adverse Effects Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 NSAID Renal Adverse Effects

2018 FP Notebook

93. NSAID Gastrointestinal Adverse Effects

62473009 English NSAID-associated gastropathy (disorder) , Non-steroidal anti-inflammatory drug-associated gastropathy , Non-steroidal anti-inflammatory drug (NSAID)-associated gastropathy , Non-steroidal anti-inflammatory drug-associated gastropathy (disorder) , Non-steroidal anti-inflammatory drug (NSAID)-associated gastropathy (disorder) , NSAID-associated gastropathy , Nonsteroidal anti-inflammatory drug-associated gastropathy Spanish gastropatía asociada a antinflamatorios no esteroides (trastorno (...) Gastrointestinal Adverse Effects NSAID Gastrointestinal Adverse Effects Aka: NSAID Gastrointestinal Adverse Effects II. Risk Factors: NSAID related GI adverse effects Age over 60 years (decreased GI protection) history Concurrent use Concurrent oral ( , ) High dose III. Risk Factors: Relative Risks of GI adverse effects Lowest Risk: s (Selective) ( ) ( ) Low Risk (Non-Selective s) ( 1.0 to 2.7) Fenoprofen or Nalfon ( 1.6) ( 1.6) Diclofenac or Voltaren ( 1.8 to 4.0) Sulindac or Clinoril ( 2.1) Nabumetone

2018 FP Notebook

94. Topical nonsteroidal anti-inflammatory drugs for osteoarthritis. (Abstract)

Topical nonsteroidal anti-inflammatory drugs for osteoarthritis. Nonsteroidal anti-inflammatory drugs (NSAIDs) are mainstays of the treatment of osteoarthritis (OA) but have dose- and age-related risks of gastrointestinal, cardiovascular, and renal adverse events (AEs). As a result, US and international guidelines recommend caution when prescribing oral NSAIDs, particularly in older patients and those with significant comorbidities. For OA of the hands and knees, topical NSAIDs provide efficacy (...) similar to oral NSAIDs, with far less systemic distribution. Treatment-related cardiovascular, renal, and other serious AEs with topical NSAIDs have not been reported. At present, only 2 topical NSAIDs are approved in the United States for the treatment of OA: diclofenac sodium 1% gel for hand or knee OA and diclofenac sodium 1.5% in 45.5% dimethylsulfoxide solution for knee OA. Clinical trial data for these products have demonstrated efficacy superior to placebo or similar to oral diclofenac with AE

2011 Postgraduate medicine

95. Study to Compare Prescription Non-Steroidal Anti-Inflammatory Drug (NSAID) Changes, Health Care Utilization, Efficacy and Safety of Meloxicam 7.5 mg Versus Usual Care Administration of Prescription NSAIDs in a Managed Healthcare Setting in Patients With O

Study to Compare Prescription Non-Steroidal Anti-Inflammatory Drug (NSAID) Changes, Health Care Utilization, Efficacy and Safety of Meloxicam 7.5 mg Versus Usual Care Administration of Prescription NSAIDs in a Managed Healthcare Setting in Patients With O Study to Compare Prescription Non-Steroidal Anti-Inflammatory Drug (NSAID) Changes, Health Care Utilization, Efficacy and Safety of Meloxicam 7.5 mg Versus Usual Care Administration of Prescription NSAIDs in a Managed Healthcare Setting (...) in Patients With Osteoarthritis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Study to Compare Prescription Non-Steroidal Anti-Inflammatory Drug (NSAID) Changes, Health Care Utilization, Efficacy and Safety

2014 Clinical Trials

96. Post-operative analgesic effects of paracetamol, NSAIDs, glucocorticoids, gabapentinoids and their combinations: a topical review. (Abstract)

, narrative review is to provide an update of the evidence for post-operative analgesic efficacy with the most commonly used, systemic non-opioid drugs, paracetamol, non-steroidal anti-inflammatory drugs (NSAIDs)/COX-2 antagonists, glucocorticoids, gabapentinoids, and combinations of these. The review is based on data from previous systematic reviews with meta-analyses, investigating effects of non-opioid analgesics on pain, opioid-requirements, and opioid-related adverse effects. Paracetamol, NSAIDs, COX (...) Post-operative analgesic effects of paracetamol, NSAIDs, glucocorticoids, gabapentinoids and their combinations: a topical review. In contemporary post-operative pain management, patients are most often treated with combinations of non-opioid analgesics, to enhance pain relief and to reduce opioid requirements and opioid-related adverse effects. A diversity of combinations is currently employed in clinical practice, and no well-documented 'gold standards' exist. The aim of the present topical

2014 Acta Anaesthesiologica Scandinavica

97. Variability in conditioned pain modulation predicts response to NSAID treatment in patients with knee osteoarthritis. (Full text)

Variability in conditioned pain modulation predicts response to NSAID treatment in patients with knee osteoarthritis. Patients with painful knee osteoarthritis (OA) demonstrate hyperalgesia and altered pain-modulatory responses. While some prior work has demonstrated cross-sectional associations between laboratory and clinical pain measures, it is unknown whether individual variability in quantitative sensory testing (QST) responses at baseline can prospectively predict analgesic treatment (...) responses.Patients with knee OA (n = 35) were compared on QST responses to a demographically-matched pain-free control group (n = 39), after which patients completed a month-long treatment study of diclofenac sodium topical gel (1 %), applied up to 4 times daily.OA patients demonstrated reduced pain thresholds at multiple anatomic sites, as well as reduced conditioned pain modulation (CPM) and enhanced temporal summation of pain. The most pain-sensitive patients tended to report the most intense and neuropathic

2016 BMC Musculoskeletal Disorders PubMed abstract

98. NSAIDs and chickenpox (Full text)

NSAIDs and chickenpox 27231291 2017 05 19 2018 11 13 1478-5242 66 647 2016 Jun The British journal of general practice : the journal of the Royal College of General Practitioners Br J Gen Pract NSAIDs and chickenpox. 294 10.3399/bjgp16X685381 Gilbert Annabel A Oxford University Medical School, Oxford. E-mail: annabel.gilbert@doctors.org.uk. eng Letter England Br J Gen Pract 9005323 0960-1643 0 Anti-Inflammatory Agents, Non-Steroidal IM Anti-Inflammatory Agents, Non-Steroidal adverse effects (...) Chickenpox complications drug therapy Child Contraindications Humans Pediatrics Practice Guidelines as Topic Practice Patterns, Physicians' Skin Diseases, Viral chemically induced etiology Soft Tissue Infections chemically induced etiology virology 2016 5 28 6 0 2016 5 28 6 0 2017 5 20 6 0 ppublish 27231291 66/647/294-a 10.3399/bjgp16X685381 PMC4871288 Br J Gen Pract. 2016 Apr;66(645):172-3 27033477 Br J Clin Pharmacol. 2008 Feb;65(2):203-9 18251759

2016 The British Journal of General Practice PubMed abstract

99. Determinants of self-medication with NSAIDs in a Portuguese community pharmacy (Full text)

Determinants of self-medication with NSAIDs in a Portuguese community pharmacy Non-steroid anti-inflammatory drugs (NSAIDs) are a widely used therapeutic group in the world, and particularly in the Portuguese population.To compare NSAID's use by prescription and self-medication acquisition and to determine the pattern of indication of NSAIDs, their usage profile and possible implications for patients' safety.A cross-sectional design was used where individuals presenting at a community pharmacy (...) (SD=20.49). An equal proportion of individuals acquired NSAIDs by self-medication and with medical prescription (n=65; 50%). Over 4/5 of patients (n=57; 87.7%) acquiring NSAIDs without a prescription were self-medicated by their own initiative, and only 10.8% (n=7) had been advised by the pharmacist. The most commonly acquired active substances were ibuprofen and diclofenac. Self-medicated users more frequently resorted to topical NSAIDs following short term treatments. The major underlying

2016 Pharmacy Practice PubMed abstract

100. The dangers of NSAIDs: look both ways (Full text)

J Gen Pract 9005323 0960-1643 0 Anti-Inflammatory Agents, Non-Steroidal IM Anti-Inflammatory Agents, Non-Steroidal administration & dosage adverse effects Contraindications Decision Making Drug Interactions General Practice methods Hospitalization statistics & numerical data Humans Musculoskeletal Pain diagnosis drug therapy Pain Management Patient Safety standards Practice Guidelines as Topic Practice Patterns, Physicians' statistics & numerical data Risk Assessment 2016 4 2 6 0 2016 4 2 6 0 (...) The dangers of NSAIDs: look both ways 27033477 2017 05 19 2018 11 13 1478-5242 66 645 2016 Apr The British journal of general practice : the journal of the Royal College of General Practitioners Br J Gen Pract The dangers of NSAIDs: look both ways. 172-3 10.3399/bjgp16X684433 Davis Abigail A Centre for Primary Care and Public Health, Queen Mary University of London, London. Robson John J Centre for Primary Care and Public Health, Queen Mary University of London, London. eng Editorial England Br

2016 The British Journal of General Practice PubMed abstract

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