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Topical NSAID

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81. Determinants of self-medication with NSAIDs in a Portuguese community pharmacy (PubMed)

(SD=20.49). An equal proportion of individuals acquired NSAIDs by self-medication and with medical prescription (n=65; 50%). Over 4/5 of patients (n=57; 87.7%) acquiring NSAIDs without a prescription were self-medicated by their own initiative, and only 10.8% (n=7) had been advised by the pharmacist. The most commonly acquired active substances were ibuprofen and diclofenac. Self-medicated users more frequently resorted to topical NSAIDs following short term treatments. The major underlying (...) Determinants of self-medication with NSAIDs in a Portuguese community pharmacy Non-steroid anti-inflammatory drugs (NSAIDs) are a widely used therapeutic group in the world, and particularly in the Portuguese population.To compare NSAID's use by prescription and self-medication acquisition and to determine the pattern of indication of NSAIDs, their usage profile and possible implications for patients' safety.A cross-sectional design was used where individuals presenting at a community pharmacy

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2016 Pharmacy Practice

82. COX2 Selective NSAID

COX2 Selective NSAID COX2 Selective NSAID Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 COX2 Selective NSAID COX2 Selective NSAID (...) Aka: COX2 Selective NSAID , COX2 Inhibitor , COX-2 Inhibitor From Related Chapters II. Class in the COX2 selective class III. Agents COX-2 Inhibitors ( ) ( ) - withdrawn from U.S. market in 2004 Valdecoxib (Bextra) - withdrawn from U.S. market in 2005 s which favor COX-2 (alternatives to COX-2) Etodolac (Lodine) Nabumetone (Relafen) Meloxicam (Mobic) However, higher risk of IV. Advantages Less gastrointestinal adverse effects than other s See Cost may not outweigh benefits to prevent 1 : 200

2018 FP Notebook

83. NSAID Renal Adverse Effects

NSAID Renal Adverse Effects NSAID Renal Adverse Effects Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 NSAID Renal Adverse Effects (...) NSAID Renal Adverse Effects Aka: NSAID Renal Adverse Effects , Nephrotoxicity due to NSAIDs II. Epidemiology s are top cause of in elderly III. Physiology s decrease synthesis of renal prostaglandins Prostaglandins vasodilate renal vessels s therefore reduce renal blood flow IV. Risk Factors: NSAID related Acute Renal Failure Elderly Hypovolemia Ineffective circulation Concurrent medications (ARB) s V. Adverse Effects: General Renal effects Related Fluid and Electrolyte abnormalities Acute papillary

2018 FP Notebook

84. NSAID Gastrointestinal Adverse Effects

NSAID Gastrointestinal Adverse Effects NSAID Gastrointestinal Adverse Effects Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 NSAID (...) Gastrointestinal Adverse Effects NSAID Gastrointestinal Adverse Effects Aka: NSAID Gastrointestinal Adverse Effects II. Risk Factors: NSAID related GI adverse effects Age over 60 years (decreased GI protection) history Concurrent use Concurrent oral ( , ) High dose III. Risk Factors: Relative Risks of GI adverse effects Lowest Risk: s (Selective) ( ) ( ) Low Risk (Non-Selective s) ( 1.0 to 2.7) Fenoprofen or Nalfon ( 1.6) ( 1.6) Diclofenac or Voltaren ( 1.8 to 4.0) Sulindac or Clinoril ( 2.1) Nabumetone

2018 FP Notebook

85. Ocular NSAID

Ocular NSAID Ocular NSAID Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Ocular NSAID Ocular NSAID Aka: Ocular NSAID , Ocular (...) Nonsteroidal Antiinflammatory Drug , Ketorolac Ophthalmic , Acular , Diclofenac Ophthalmic , Voltaren Ophthalmic II. Indications III. Preparations 0.5% (Acular) 1 drop qid x7d Diclofenac 0.1% (Voltaren) 1 drop qid Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Ocular NSAID." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Cost: Medications acular (on 1/1/2017

2018 FP Notebook

86. A Study To Assess The Efficacy And Safety Of Bismuth Tripotassium Dicitrate (De-Nol) In Combination With Pantoprazole And Pantoprazole Monotherapy In Treatment Of Subjects With Nonsteroidal Anti-Inflammatory Drugs (NSAID)-Induced Gastropathy

The Efficacy And Safety Of Bismuth Tripotassium Dicitrate (De-Nol®) In Combination With Pantoprazole And Pantoprazole Monotherapy In Treatment Of Patients With NSAID Induced Gastropathy Actual Study Start Date : March 3, 2017 Actual Primary Completion Date : May 29, 2017 Actual Study Completion Date : June 13, 2017 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: bismuth tripotassium dicitrate (...) A Study To Assess The Efficacy And Safety Of Bismuth Tripotassium Dicitrate (De-Nol) In Combination With Pantoprazole And Pantoprazole Monotherapy In Treatment Of Subjects With Nonsteroidal Anti-Inflammatory Drugs (NSAID)-Induced Gastropathy A Study To Assess The Efficacy And Safety Of Bismuth Tripotassium Dicitrate (De-Nol) In Combination With Pantoprazole And Pantoprazole Monotherapy In Treatment Of Subjects With Nonsteroidal Anti-Inflammatory Drugs (NSAID)-Induced Gastropathy - Full Text

2016 Clinical Trials

87. Variability in conditioned pain modulation predicts response to NSAID treatment in patients with knee osteoarthritis. (PubMed)

Variability in conditioned pain modulation predicts response to NSAID treatment in patients with knee osteoarthritis. Patients with painful knee osteoarthritis (OA) demonstrate hyperalgesia and altered pain-modulatory responses. While some prior work has demonstrated cross-sectional associations between laboratory and clinical pain measures, it is unknown whether individual variability in quantitative sensory testing (QST) responses at baseline can prospectively predict analgesic treatment (...) responses.Patients with knee OA (n = 35) were compared on QST responses to a demographically-matched pain-free control group (n = 39), after which patients completed a month-long treatment study of diclofenac sodium topical gel (1 %), applied up to 4 times daily.OA patients demonstrated reduced pain thresholds at multiple anatomic sites, as well as reduced conditioned pain modulation (CPM) and enhanced temporal summation of pain. The most pain-sensitive patients tended to report the most intense and neuropathic

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2016 BMC Musculoskeletal Disorders

88. NSAIDs and chickenpox (PubMed)

NSAIDs and chickenpox 27231291 2017 05 19 2018 11 13 1478-5242 66 647 2016 Jun The British journal of general practice : the journal of the Royal College of General Practitioners Br J Gen Pract NSAIDs and chickenpox. 294 10.3399/bjgp16X685381 Gilbert Annabel A Oxford University Medical School, Oxford. E-mail: annabel.gilbert@doctors.org.uk. eng Letter England Br J Gen Pract 9005323 0960-1643 0 Anti-Inflammatory Agents, Non-Steroidal IM Anti-Inflammatory Agents, Non-Steroidal adverse effects (...) Chickenpox complications drug therapy Child Contraindications Humans Pediatrics Practice Guidelines as Topic Practice Patterns, Physicians' Skin Diseases, Viral chemically induced etiology Soft Tissue Infections chemically induced etiology virology 2016 5 28 6 0 2016 5 28 6 0 2017 5 20 6 0 ppublish 27231291 66/647/294-a 10.3399/bjgp16X685381 PMC4871288 Br J Gen Pract. 2016 Apr;66(645):172-3 27033477 Br J Clin Pharmacol. 2008 Feb;65(2):203-9 18251759

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2016 The British Journal of General Practice

89. Safety of Topical Non-steroidal Anti-Inflammatory Drugs in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis. (PubMed)

Safety of Topical Non-steroidal Anti-Inflammatory Drugs in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis. We aimed to assess the safety of topical non-steroidal anti-inflammatory drugs (NSAIDs) in the management of osteoarthritis (OA) in a systematic review and meta-analysis of randomized, placebo-controlled trials.A comprehensive literature search was undertaken in the MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), and Scopus electronic databases (...) . Randomized, double-blind, placebo-controlled, parallel-group trials that assessed adverse events (AEs) with topical NSAIDs in patients with OA were eligible for inclusion. Authors and/or study sponsors were contacted to obtain the full report of AEs. The primary outcomes were overall severe and serious AEs, as well as the following MedDRA System Organ Class (SOC)-related AEs: gastrointestinal, vascular, cardiac, nervous system, skin and subcutaneous tissue, musculoskeletal and connective tissue.The

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2019 Drugs & Aging

90. Efficacy and safety of loxoprofen sodium topical patch for the treatment of pain in patients with minor acute traumatic limb injuries in Brazil: a randomized, double-blind, non-inferiority trial. (PubMed)

Efficacy and safety of loxoprofen sodium topical patch for the treatment of pain in patients with minor acute traumatic limb injuries in Brazil: a randomized, double-blind, non-inferiority trial. Post-traumatic injury pain is commonly treated with oral nonsteroidal anti-inflammatory drugs (NSAIDs). However, oral NSAIDs causes several adverse events, with topical formulations arising as an important alternative. Therefore, we aimed to evaluate the efficacy and safety of loxoprofen patch

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2019 Pain Controlled trial quality: predicted high

91. [The question about the topical antibiotic therapy of acute rhinosinusitis]. (PubMed)

irrigation therapy, and NSAIDs. In the control group, topical decongestants were used; in the experimental group the antimicrobial drug Polydexa with phenylephrine was used as a local therapy. The purpose of the study was to evaluate the clinical efficacy of Polydexa with phenylephrine in the complex treatment of moderate acute rhinosinusitis. The evaluation criteria were statistically significant comparison of clinical and laboratory parameters of both groups. Confirmed the anti-inflammatory (...) [The question about the topical antibiotic therapy of acute rhinosinusitis]. Presented the results of the clinical study of 30 patients with moderate rhinosinusitis (13 (43.3%) men, 17 (56.7%) women, age from 18 to 68 years). Among those patients, the inflammation of one paranasal sinus was observed in 7 (23.3%) cases, polysinusitis was observed in 23 (76. 7%) cases. All patients were randomized into 2 groups of 15 people. In both groups, patients received systemic antibiotic therapy, nasal

2019 Vestnik otorinolaringologii Controlled trial quality: uncertain

92. Topical NSAID formulations. (PubMed)

Topical NSAID formulations. This article reviews topical nonsteroidal anti-inflammatory drug (NSAID) formulations available in the United States, including advantages and disadvantages, therapeutic usefulness, adverse effects, and formulation considerations.In the United States, several topical NSAID products are approved to treat painful conditions including diclofenac sodium 1% gel (Voltaren Gel®; Endo Pharmaceuticals), diclofenac sodium topical solution 1.5% w/w in 45.5% dimethyl sulfoxide (...) (PENNSAID®; Mallinckrodt, Inc.), and diclofenac epolamine 1.3% (Flector Patch®; Alpharma Pharmaceuticals LLC, a subsidiary of Pfizer, Inc.). Recent studies suggest topical diclofenac preparations are effective for osteoarthritis pain and suggest the efficacy of topical formulations is similar to that achieved with oral NSAID formulations. All NSAID formulations contain the same boxed warnings regarding cardiovascular and renal toxicity; however, topical NSAIDs are proposed to have a more favorable

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2013 Pain Medicine

93. Relative efficacy of topical non-steroidal anti-inflammatory drugs and topical capsaicin in osteoarthritis: protocol for an individual patient data meta-analysis. (PubMed)

will be conducted. The study aims to investigate the relative treatment effects of topical non-steroidal anti-inflammatory drugs (NSAIDs) and topical capsaicin in OA and to identify patient-level predictors of treatment response.IPD will be collected from randomised controlled trials (RCTs) of topical NSAIDs and capsaicin in OA. Multilevel regression modelling will be conducted to determine predictors for the specific and the overall treatment effect.Through the identification of treatment responders, this IPD (...) Relative efficacy of topical non-steroidal anti-inflammatory drugs and topical capsaicin in osteoarthritis: protocol for an individual patient data meta-analysis. Pain is the most troubling issue to patients with osteoarthritis (OA), yet current pharmacological treatments offer only small-to-moderate pain reduction. Current guidelines therefore emphasise the need to identify predictors of treatment response. In line with these recommendations, an individual patient data (IPD) meta-analysis

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2016 Systematic reviews

94. Study to Compare Prescription Non-Steroidal Anti-Inflammatory Drug (NSAID) Changes, Health Care Utilization, Efficacy and Safety of Meloxicam 7.5 mg Versus Usual Care Administration of Prescription NSAIDs in a Managed Healthcare Setting in Patients With O

and Safety of Meloxicam 7.5 mg Versus Usual Care Administration of Prescription NSAIDs in a Managed Healthcare Setting in Patients With Osteoarthritis of the Hip, Knee, Hand or Spine Study Start Date : October 1998 Actual Primary Completion Date : November 2000 Resource links provided by the National Library of Medicine related topics: related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Meloxicam Drug: Meloxicam Active Comparator: Usual care prescription (...) Study to Compare Prescription Non-Steroidal Anti-Inflammatory Drug (NSAID) Changes, Health Care Utilization, Efficacy and Safety of Meloxicam 7.5 mg Versus Usual Care Administration of Prescription NSAIDs in a Managed Healthcare Setting in Patients With O Study to Compare Prescription Non-Steroidal Anti-Inflammatory Drug (NSAID) Changes, Health Care Utilization, Efficacy and Safety of Meloxicam 7.5 mg Versus Usual Care Administration of Prescription NSAIDs in a Managed Healthcare Setting

2014 Clinical Trials

95. Cost effectiveness of etoricoxib versus celecoxib and non-selective NSAIDs in the treatment of ankylosing spondylitis

Cost effectiveness of etoricoxib versus celecoxib and non-selective NSAIDs in the treatment of ankylosing spondylitis Cost effectiveness of etoricoxib versus celecoxib and non-selective NSAIDs in the treatment of ankylosing spondylitis Cost effectiveness of etoricoxib versus celecoxib and non-selective NSAIDs in the treatment of ankylosing spondylitis Jansen JP, Gaugris S, Choy EH, Ostor A, Nash JT, Stam W Record Status This is a critical abstract of an economic evaluation that meets (...) the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study evaluated the cost-effectiveness of etoricoxib compared with celecoxib, diclofenac, and naproxen for patients with ankylosing spondylitis, who required routine non-steroidal anti-inflammatory drug (NSAID) treatment. The authors concluded that their economic

2010 NHS Economic Evaluation Database.

96. Combination of topical NSAIDs and anti-VEGF for age-related macular degeneration treatment

Combination of topical NSAIDs and anti-VEGF for age-related macular degeneration treatment Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address

2016 PROSPERO

97. Topical NSAIDs for chronic musculoskeletal pain in adults. (PubMed)

Topical NSAIDs for chronic musculoskeletal pain in adults. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly taken orally, but they are also available in topical preparations to be applied to or rubbed onto the skin of a painful joint, typically one affected by arthritis, with the aim of relieving pain locally. Topical NSAIDs are widely used in some parts of the world for acute and chronic painful conditions, but have not been universally accepted until recently. One of the problems (...) has been that older clinical studies were generally short, lasting four weeks or less, and short duration studies are not regarded as adequate in ongoing painful conditions.To examine the use of topical NSAIDs in chronic musculoskeletal pain, focusing on studies of high methodological quality, and examining the measured effect of the preparations according to study duration. The principal aim was to estimate treatment efficacy in longer duration studies of at least 8 weeks.A series of electronic

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2012 Cochrane database of systematic reviews (Online)

98. A Repeat Insult Patch Test (RIPT) Study Evaluating the Sensitization Potential of Topical SM04755 Solution in Healthy Volunteers

(e.g., NSAIDs, high dose aspirin, etc.) within 1 week prior to Day 1. Note: Daily use of ≤325 mg of aspirin for cardiovascular disease or prophylaxis is allowed. Maximum daily use of Tylenol ≤3000 mg is allowed. Antihistamines within 1 week prior to Day 1. Note: H2 blockers such as Pepcid, Zantac, and Tagamet are permitted. Anti-inflammatories within 1 week prior to Day 1 Immunosuppressant medications (e.g., TNF-alpha inhibitors, topical tacrolimus, etc.) within 4 weeks prior to Day 1 (or within 6 (...) A Repeat Insult Patch Test (RIPT) Study Evaluating the Sensitization Potential of Topical SM04755 Solution in Healthy Volunteers A Repeat Insult Patch Test (RIPT) Study Evaluating the Sensitization Potential of Topical SM04755 Solution in Healthy Volunteers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have

2018 Clinical Trials

99. To Study Generic Calcipotriene and Betamethasone Dipropionate Topical Foam, 0.005%/0.064%, in the Treatment of Psoriasis Vulgaris (Plaque Psoriasis).

To Study Generic Calcipotriene and Betamethasone Dipropionate Topical Foam, 0.005%/0.064%, in the Treatment of Psoriasis Vulgaris (Plaque Psoriasis). To Study Generic Calcipotriene and Betamethasone Dipropionate Topical Foam, 0.005%/0.064%, in the Treatment of Psoriasis Vulgaris (Plaque Psoriasis). - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved (...) Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. To Study Generic Calcipotriene and Betamethasone Dipropionate Topical Foam, 0.005%/0.064%, in the Treatment of Psoriasis Vulgaris (Plaque Psoriasis). The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical

2018 Clinical Trials

100. The relative efficacy of topical non-steroidal anti-inflammatory drugs and capsaicin in osteoarthritis: A network meta-analysis of randomised controlled trials. (PubMed)

The relative efficacy of topical non-steroidal anti-inflammatory drugs and capsaicin in osteoarthritis: A network meta-analysis of randomised controlled trials. To compare the efficacy of topical non-steroidal anti-inflammatory drugs (NSAIDs) with topical capsaicin for pain relief in osteoarthritis (OA).A systematic literature search was conducted for randomised controlled trials (RCTs) examining any topical NSAID or capsaicin in OA. Pain relief at or nearest to 4 weeks was pooled using (...) a random-effects network meta-analysis (NMA) in a Frequentist and Bayesian setting. Analysis was conducted for all trials and for trials using drugs listed as licensed for OA in the British National Formulary (BNF).The trial network comprised 28 RCTs (7372 participants), of which 17 RCTs (3174 participants) were included in the as licensed analyses. No RCTs directly compared topical NSAIDs with capsaicin. Placebo was the only common comparator for topical NSAIDs and capsaicin. Frequentist and Bayesian

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2018 Osteoarthritis and Cartilage

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