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Topical NSAID

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41. Topical NSAIDs effect on corneal sensitivity. (PubMed)

Topical NSAIDs effect on corneal sensitivity. Topical nonsteroidal antiinflammatory drugs (NSAIDs) are administered topically for a variety of ophthalmologic conditions. Brand diclofenac and brand ketorolac were previously shown to have topical anesthetic effects in addition to analgesic effects. Using the same method, we measured similar anesthetic effects of the 4 currently available topical NSAIDs--generic diclofenac, generic ketorolac, brand bromfenac, and brand nepafenac.Baseline corneal (...) sensitivity was measured on 10 healthy adult volunteers with a Cochet-Bonnet esthesiometer. One drop of the agent being studied was applied to the right eye every 5 minutes for a total of 4 drops. Corneal sensitivity was measured immediately after the last topical application and every 15 minutes for 60 minutes. After a 1-week washout period, a different agent was studied until all 4 NSAIDs were evaluated.Corneal sensitivity profiles over time were similar for all NSAIDs. Corneal sensitivity decreased

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2015 Cornea Controlled trial quality: uncertain

42. Narcotics vs NSAIDs for Post-operative Analgesia in Outpatient Rhinoplasty

Narcotics vs NSAIDs for Post-operative Analgesia in Outpatient Rhinoplasty Narcotics vs NSAIDs for Post-operative Analgesia in Outpatient Rhinoplasty - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Narcotics vs NSAIDs for Post-operative Analgesia in Outpatient Rhinoplasty The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03457116 Recruitment Status : Enrolling by invitation First Posted : March 7, 2018 Last Update Posted : February 21, 2019 Sponsor: New York University School of Medicine Information

2018 Clinical Trials

43. Dry Needling and Spinal Manipulation vs. Interocclusal Appliance (Splint), NSAIDs and Joint Mobs for Temporomandibular Dysfunction

related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Dry Needling and Spinal Manipulation Other: Dry Needling Dry needling to the muscle of mastication and temporomandibular joint capsule. 1-2 treatment sessions per week for up to 4 weeks Other: Spinal manipulation Spinal manipulation, targeting the upper cervical spine (C1-C2, C2-C3 or OA). 1-2 treatments per week for up to 4 weeks. Active Comparator: Interocclusal Appliance, NSAIDs and TMJ Mobs Other: Interocclusal (...) Dry Needling and Spinal Manipulation vs. Interocclusal Appliance (Splint), NSAIDs and Joint Mobs for Temporomandibular Dysfunction Dry Needling and Spinal Manipulation vs. Interocclusal Appliance (Splint), NSAIDs and Joint Mobs for Temporomandibular Dysfunction - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have

2018 Clinical Trials

44. Effect of NSAID Use on Pain and Opioid Consumption Following Distal Radius Fracture

Effect of NSAID Use on Pain and Opioid Consumption Following Distal Radius Fracture Effect of NSAID Use on Pain and Opioid Consumption Following Distal Radius Fracture - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Effect of NSAID Use on Pain and Opioid Consumption Following Distal Radius Fracture (Adult NSAID) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03749616 Recruitment Status : Recruiting First Posted

2018 Clinical Trials

45. NSAID vs Steroid in Trabeculectomy Wound Management

Society of Canada Information provided by (Responsible Party): Cindy Hutnik, Ivey Eye Institute Study Details Study Description Go to Brief Summary: This study will examine the efficacy of steroid vs NSAID treatment in relation to trabeculectomy wound management. Eligible study participants will be randomized to receive either steroid or NSAID topical treatment one week post-trabeculectomy. Each group will dose with their assigned study treatment until three months post-trabeculectomy. Study (...) Clinical Trial to Examine the Efficacy of Peri-operative NSAID vs Steroid Treatment in Trabeculectomy Wound Management Estimated Study Start Date : April 2019 Estimated Primary Completion Date : September 2020 Estimated Study Completion Date : March 2021 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: NSAID Nepafenac 0.1% Oph Susp: used from one week post-op to three months post-op Drug

2018 Clinical Trials

46. Are NSAIDs Effective Enough for Postoperative Pain Control After Functional Endoscopic Sinus Surgery and Septoplasty

) Primary Purpose: Treatment Official Title: Are NSAIDs Effective Enough for Postoperative Pain Control After Functional Endoscopic Sinus Surgery and Septoplasty Actual Study Start Date : August 1, 2018 Estimated Primary Completion Date : April 2019 Estimated Study Completion Date : July 2019 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: NSAID The non-steroidal anti-inflammatory drug (NSAID (...) Are NSAIDs Effective Enough for Postoperative Pain Control After Functional Endoscopic Sinus Surgery and Septoplasty Are NSAIDs Effective Enough for Postoperative Pain Control After Functional Endoscopic Sinus Surgery and Septoplasty - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2018 Clinical Trials

47. PGE2 Levels in Patient Treated With NSAIDs

, "Yellox®", NSAID eyedrops administered three days before surgery Drug: Yellox Dosing of drug 3 days prior to surgery Other Name: Bromfenac 0.09 % Ophthalmic Solution Outcome Measures Go to Primary Outcome Measures : Vitreous NSAIDs and PGE2 levels [ Time Frame: 3 days after topical NSAID administration ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends (...) glaucoma concurrent retinovascular disease previous ocular inflammation previous ocular surgery history of ocular trauma previuos intravitreal injections concomitant intake of topical or systemic NSAIDs or corticosteroid therapy Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov

2018 Clinical Trials

48. NSAIDs Stent Study

: Supportive Care Official Title: A Prospective, Randomized, Pilot Study of Preoperative Anti-Inflammatory Therapy for Ureteral Stent Symptoms Actual Study Start Date : July 31, 2018 Estimated Primary Completion Date : October 2020 Estimated Study Completion Date : October 2021 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Intervention Group - Ketorlac (NSAID) Subjects will receive a one (...) NSAIDs Stent Study NSAIDs Stent Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. NSAIDs Stent Study The safety and scientific validity of this study is the responsibility of the study sponsor

2018 Clinical Trials

49. Examining the Role of Improved NSAID Management in Treating Dysmenorrhea and Bladder Pain

participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Examining the Role of Improved NSAID Management in Treating Dysmenorrhea and Bladder Pain Actual Study Start Date : May 9, 2018 Estimated Primary Completion Date : May 1, 2020 Estimated Study Completion Date : May 1, 2021 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental (...) Examining the Role of Improved NSAID Management in Treating Dysmenorrhea and Bladder Pain Examining the Role of Improved NSAID Management in Treating Dysmenorrhea and Bladder Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2018 Clinical Trials

50. NSAIDs vs. Coxibs in the Presence of Aspirin

NSAIDs vs. Coxibs in the Presence of Aspirin NSAIDs vs. Coxibs in the Presence of Aspirin - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. NSAIDs vs. Coxibs in the Presence of Aspirin The safety (...) ): Inova Health Care Services Study Details Study Description Go to Brief Summary: The objectives of this single site, randomized, crossover study is to evaluate the pharmacodynamic interactions between aspirin, NSAIDs and Coxibs with respect to platelet function, biomarkers of inflammation and endothelial function. Condition or disease Intervention/treatment Phase Rheumatoid Arthritis Cardiovascular Diseases Drug: celecoxib 200mg capsule Drug: naproxen sodium 550mg tablet Drug: Aspirin 81mg tablet

2018 Clinical Trials

51. Drug Provocation Test (DPT) to Non Steroidal Anti-inflammatory Drugs (NSAID)

Completion Date : January 1, 2019 Estimated Study Completion Date : January 30, 2019 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Outcome Measures Go to Primary Outcome Measures : Detect eliciting dose thresholds during NSAIDs DPT optimal step doses [ Time Frame: 1 day ] The DPT was considered positive if objective signs occurred during NSAIDs administration. The reactive dose (RD) was calculated from the total cumulative dose (mg) reached when (...) Drug Provocation Test (DPT) to Non Steroidal Anti-inflammatory Drugs (NSAID) Drug Provocation Test (DPT) to Non Steroidal Anti-inflammatory Drugs (NSAID) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Drug

2018 Clinical Trials

52. Post Implantation Syndrome and Administration on NSAIDs in Patients Undergoing EVAR for AAA

Post Implantation Syndrome and Administration on NSAIDs in Patients Undergoing EVAR for AAA Post Implantation Syndrome and Administration on NSAIDs in Patients Undergoing EVAR for AAA - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Post Implantation Syndrome and Administration on NSAIDs in Patients Undergoing EVAR for AAA The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03727412 Recruitment Status : Recruiting First Posted

2018 Clinical Trials

53. Efficacy and Safety of Oxycodone/Naloxone (Targin®) in Persistent Moderate to Severe Low Back Pain Following NSAIDs Treatment

/Naloxone (Targin®) in Moderate to Severe Low Back Pain Patients Who Are Not Adequately Controlled by NSAIDs Actual Study Start Date : November 21, 2018 Estimated Primary Completion Date : December 2019 Estimated Study Completion Date : April 2020 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Brand Name: Targin® Brand Name: Targin® Generic name: Oxycodone/Naloxone dosage form: Oral Drug (...) Efficacy and Safety of Oxycodone/Naloxone (Targin®) in Persistent Moderate to Severe Low Back Pain Following NSAIDs Treatment Efficacy and Safety of Oxycodone/Naloxone (Targin®) in Persistent Moderate to Severe Low Back Pain Following NSAIDs Treatment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2018 Clinical Trials

54. Effect of NSAIDs on Pupil Diameter and Expression of Aqueous Humor Cytokines in FLACS Versus Conventional Phacoemulsification. (PubMed)

Effect of NSAIDs on Pupil Diameter and Expression of Aqueous Humor Cytokines in FLACS Versus Conventional Phacoemulsification. To compare the concentrations of interleukin (IL) (IL-1b, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70), interferon (IFN)-γ, tumor necrosis factor (TNF)-α, and TNF-β in the aqueous humor of patients undergoing femtosecond laser-assisted cataract surgery (FLACS) and corneal mechanical paracentesis treated with two different topical nonsteroidal anti-inflammatory drugs (...) (NSAIDs): bromfenac and indomethacin.In this prospective, randomized controlled, single-center study, aqueous humor samples were obtained immediately after performing the femtosecond laser procedure or at the start of conventional phacoemulsification. Preoperatively, the FLACS groups were administered (once daily and four times daily, respectively) either topical bromfenac 0.09% (12 eyes) or indomethacin 0.1% (12 eyes). The corneal paracentesis bromfenac and indomethacin groups received the same

2018 Journal of Refractive Surgery Controlled trial quality: uncertain

55. The Effect of NSAID Pretreatment on Aqueous Humor Prostaglandin E2 Concentration in Eyes Undergoing Femtosecond Laser-Assisted Capsulotomy (PubMed)

The Effect of NSAID Pretreatment on Aqueous Humor Prostaglandin E2 Concentration in Eyes Undergoing Femtosecond Laser-Assisted Capsulotomy To assess aqueous humor concentration of prostaglandin E2 (PGE2) after capsulotomy creation using a femtosecond laser (FLAC) in patients pretreated with short-term topical ketorolac versus patients without pretreatment.This prospective study comprised consecutive patients scheduled to undergo cataract surgery using a femtosecond laser platform to perform (...) only capsulotomies. An identical protocol for preoperative mydriasis was used for all the eyes included in the study, while aqueous humor was extracted from the anterior chamber of all patients immediately after the initial side port incision. ELISA was performed to quantify aqueous humor PGE2. The patients were divided into 2 groups; in group 1, the patients received short-term topical ketorolac preoperatively, while the patients in group 2 did not receive NSAID pretreatment.Twenty eyes of 20

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2018 Journal of ophthalmology Controlled trial quality: uncertain

56. Post-operative analgesic effects of paracetamol, NSAIDs, glucocorticoids, gabapentinoids and their combinations: a topical review. (PubMed)

Post-operative analgesic effects of paracetamol, NSAIDs, glucocorticoids, gabapentinoids and their combinations: a topical review. In contemporary post-operative pain management, patients are most often treated with combinations of non-opioid analgesics, to enhance pain relief and to reduce opioid requirements and opioid-related adverse effects. A diversity of combinations is currently employed in clinical practice, and no well-documented 'gold standards' exist. The aim of the present topical (...) , narrative review is to provide an update of the evidence for post-operative analgesic efficacy with the most commonly used, systemic non-opioid drugs, paracetamol, non-steroidal anti-inflammatory drugs (NSAIDs)/COX-2 antagonists, glucocorticoids, gabapentinoids, and combinations of these. The review is based on data from previous systematic reviews with meta-analyses, investigating effects of non-opioid analgesics on pain, opioid-requirements, and opioid-related adverse effects. Paracetamol, NSAIDs, COX

2014 Acta Anaesthesiologica Scandinavica

57. Comparison of NSAID Patch Given in Monotherapy and NSAID Patch in Combination With Transcutaneous Electric Nerve Stimulation, Heating Pad, or Topical Capsaicin in the Treatment of Patients With Myofascial Pain Syndrome of the Upper Trapezius: A Pilot Stud

Comparison of NSAID Patch Given in Monotherapy and NSAID Patch in Combination With Transcutaneous Electric Nerve Stimulation, Heating Pad, or Topical Capsaicin in the Treatment of Patients With Myofascial Pain Syndrome of the Upper Trapezius: A Pilot Stud Comparison of NSAID Patch Given in Monotherapy and NSAID Patch in Combination With Transcutaneous Electric Nerve Stimulation, Heating Pad, or Topical Capsaicin in the Treatment of Patients With Myofascial Pain Syndrome of the Upper Trapezius (...) : A Pilot Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Comparison of NSAID Patch Given in Monotherapy and NSAID Patch in Combination With Transcutaneous Electric Nerve Stimulation, Heating Pad, or Topical

2013 Clinical Trials

58. Cohort study: In infants born extremely preterm, aspirin or NSAID use during pregnancy are associated with increased risk of quadriparetic cerebral palsy

-inflammatory drugs (NSAIDs) may increase the risk of cerebral palsy in extremely preterm infants. It would seem, however, that aspirin given to women at high-risk for pre-eclampsia may be beneficial. Exposure to NSAIDs should be considered with caution until further information is available. Context The issue of taking medications during pregnancy and the risks involved has been the topic of many reviews. Aspirin is a NSAID that is prescribed to prevent recurrent abortion and to reduce the risk of pre (...) Cohort study: In infants born extremely preterm, aspirin or NSAID use during pregnancy are associated with increased risk of quadriparetic cerebral palsy In infants born extremely preterm, aspirin or NSAID use during pregnancy are associated with increased risk of quadriparetic cerebral palsy | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we

2014 Evidence-Based Nursing

59. Retrospective Review of NSAIDS in the Postpartum Period

. There are two articles available in the obstetrics literature on the topic of NSAIDS in women with hypertension disorders. The first is by Makis et al, and is a case series of six women, with discussion of two cases. The explanations of hypertension causes are limited and possible alternate diagnoses are not discussed (6). The second by Wasden et al is a retrospective study of women who had the diagnosis of severe hypertension disorders in pregnancy. The patients were matched 2:1 for women exposed to NSAIDs (...) : Retrospective Official Title: Hypertension and NSAIDS in the Postpartum Period Actual Study Start Date : January 18, 2017 Estimated Primary Completion Date : April 2018 Estimated Study Completion Date : April 2019 Resource links provided by the National Library of Medicine related topics: related topics: Groups and Cohorts Go to Group/Cohort Intervention/treatment NSAID use The purpose of this study is to establish that NSAIDS are an appropriate analgesic to be used in the postpartum period, and thus women

2017 Clinical Trials

60. The effect of NSAIDs on spinal fusion: a cross-disciplinary review of biochemical, animal, and human studies. (PubMed)

The effect of NSAIDs on spinal fusion: a cross-disciplinary review of biochemical, animal, and human studies. Non-steroidal anti-inflammatory drugs (NSAIDs) play an important role in postoperative pain management. However, their use in the setting of spine fusion surgery setting has long been a topic of controversy. In this review we examined relevant research, including in vivo, animal, and clinical human studies, with the aim of understanding the effect of NSAIDs on spinal fusion.Systematic (...) review of study designs of all types from randomized controlled trials and meta-analyses to single-institution retrospective reviews.A search of PubMed and Embase was conducted using the keywords: "spine," "spinal fracture," NSAIDs, anti-inflammatory non-steroidal agents, bone, bone healing, fracture, fracture healing, yielding a total of 110 studies. Other 28 studies were identified by cross-referencing, resulting in total 138 studies.There is no level I evidence from human studies regarding the use

2017 European Spine Journal

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