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Topical NSAID

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41. Non Steroidal Antiinflammatory Drugs Influence on Heal of Distal Radius Fracture

: University of Aarhus Information provided by (Responsible Party): Marius Aliuskevicius, Aalborg Universitetshospital Study Details Study Description Go to Brief Summary: It is believed, that Non Steroidal Antiinflammatory Drug (NSAID) drugs slows bone healing, but the knowledge is based only on animal studies, and the results are automatically raised for the people. Many patients with bone fracture must therefore avoid the formerly so popular and good painkillers, although no clinical trial evidence (...) -Steroidal Anti-Inflammatory Agents Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Antirheumatic Agents Cyclooxygenase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action

2012 Clinical Trials

42. Safety and Efficacy of Nonsteroidal Antiinflammatory (NSAI)Drug and Glucocorticoids in Acute Sciatica

Neuralgia Pain Neurologic Manifestations Signs and Symptoms Methylprednisolone Methylprednisolone Acetate Methylprednisolone Hemisuccinate Prednisolone Prednisolone acetate Ketoprofen Anti-Inflammatory Agents Prednisolone hemisuccinate Prednisolone phosphate Glucocorticoids Anti-Inflammatory Agents, Non-Steroidal Antiemetics Autonomic Agents Peripheral Nervous System Agents Physiological Effects of Drugs Gastrointestinal Agents Hormones Hormones, Hormone Substitutes, and Hormone Antagonists (...) Responsible Party: University Hospital, Grenoble ClinicalTrials.gov Identifier: Other Study ID Numbers: 1201 First Posted: March 22, 2013 Last Update Posted: March 24, 2016 Last Verified: March 2016 Keywords provided by University Hospital, Grenoble: sciatica Anti-Inflammatory Agents, Non-Steroidal Glucocorticoids Additional relevant MeSH terms: Layout table for MeSH terms Sciatica Sciatic Neuropathy Mononeuropathies Peripheral Nervous System Diseases Neuromuscular Diseases Nervous System Diseases

2013 Clinical Trials

43. Nonsteroidal Antiinflammatory Drugs in Women With Postpartum Pre-eclampsia

Identifier: Other Study ID Numbers: Complejoh 02 First Posted: November 20, 2013 Last Update Posted: July 28, 2015 Last Verified: July 2015 Additional relevant MeSH terms: Layout table for MeSH terms Eclampsia Pre-Eclampsia Hypertension, Pregnancy-Induced Pregnancy Complications Acetaminophen Ibuprofen Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Antipyretics Anti-Inflammatory Agents (...) Nonsteroidal Antiinflammatory Drugs in Women With Postpartum Pre-eclampsia Nonsteroidal Antiinflammatory Drugs in Women With Postpartum Pre-eclampsia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2013 Clinical Trials

44. Efficacy of Nonsteroidal Anti-inflammatory Drugs in Treatment of Moderate and Severe Dry Eye Disease

: March 2012 Actual Primary Completion Date : June 2012 Actual Study Completion Date : July 2012 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: group 1 Drug: nonsteroid anti-inflammatory drops nonsteroid anti-inflammatory drops plus artificial tear substitute Other Name: prunoprefen Experimental: group 2 Drug: nonsteroid anti-inflammatory drops nonsteroid anti-inflammatory drops plus artificial tear (...) Efficacy of Nonsteroidal Anti-inflammatory Drugs in Treatment of Moderate and Severe Dry Eye Disease Efficacy of Nonsteroidal Anti-inflammatory Drugs in Treatment of Moderate and Severe Dry Eye Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2012 Clinical Trials

45. NSAIDs in Sciatica NSAIDS IN SCIATICA

is an established term for pain radiating from the lower back or buttock into the leg, commonly caused by a disc herniation. Given their analgesic and anti-inflammatory mechanisms of action, NSAIDs (Non-steroidal anti-inflammatory drugs) have been, and are still being regarded as standard therapy for sciatica. However, very few randomised controlled trials of NSAIDs have been undertaken in sciatica, and no study has showed clinically meaningful effects as compared to placebo. Since NSAIDs involve the risk (...) -Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anti-Inflammatory Agents Antirheumatic Agents Gout Suppressants Cyclooxygenase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action

2017 Clinical Trials

46. NSAIDs Versus Paracetamol Versus Paracetamol + NSAIDs in Traumatic Pain Management

relevant MeSH terms: Layout table for MeSH terms Acute Pain Pain Neurologic Manifestations Signs and Symptoms Acetaminophen Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Antipyretics Anti-Inflammatory Agents Antirheumatic Agents (...) Update Posted : July 19, 2017 See Sponsor: University of Monastir Information provided by (Responsible Party): Pr. Semir Nouira, University of Monastir Study Details Study Description Go to Brief Summary: The purpose of this study is to: Compare the effect of paracetamol alone against NSAIDs alone against the association of paracetamol + NSAIDs in the treatment of traumatic pain. Condition or disease Intervention/treatment Phase Acute Pain Due to Trauma Drug: Paracetamol Drug: NSAID Drug: Placebo

2017 Clinical Trials

48. Comparative Risk of Cardiovascular Outcomes Between Topical and Oral Nonselective NSAIDs in Taiwanese Patients With Rheumatoid Arthritis Full Text available with Trip Pro

Comparative Risk of Cardiovascular Outcomes Between Topical and Oral Nonselective NSAIDs in Taiwanese Patients With Rheumatoid Arthritis Topical NSAIDs have less systemic absorption than oral NSAIDs. We examined the risk of cardiovascular events associated with nonselective topical NSAIDs versus oral NSAIDs among patients with rheumatoid arthritis in Taiwan.We conducted a retrospective cohort study that included patients with incident rheumatoid arthritis who were newly starting therapy (...) with nonselective topical NSAIDs or oral NSAIDs. We used the Taiwan National Health Insurance Research Database (NHIRD). The first date patients received either type of NSAID was defined as the index date. NSAID exposures continued until there was a treatment gap of >30 days. The main outcome was composite cardiovascular events, including myocardial infarction, unstable angina, heart failure, stroke, or revascularization. Follow-up was censored at treatment discontinuation, switch or addition of other NSAID

2017 Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

49. NSAIDs: Inflamed effects on inflammation?

: Inflamed effects on inflammation? Clinical Question: Do non-steroidal anti-inflammatory drugs (NSAIDs) reduce swelling and inflammation in acute injury? Bottom Line: Randomized Controlled Trials (RCTs) of NSAIDs effect on musculoskeletal injury swelling show highly inconsistent results: Some slight improvements (2-11%), some slight worsening (8%) and most no effect. It is unlikely NSAIDs have any reliable effect on acute injury swelling but they do improve pain for ~1 in 4 over one week. Evidence (...) : • NSAIDs versus other drugs: o Systematic review, ten soft tissue injury RCTs: 1 ? Mostly found no difference between adequately dosed NSAIDs (like diclofenac 150 mg/day or ibuprofen 1600 mg/day) versus acetaminophen, dihydrocodeine, or acetaminophen-opioid combinations. ? One RCT (68 patients, mixed injuries): Naproxen 1100 mg/day statistically reduced swelling ~6% versus dextropropoxyphene (Darvon™) at three days. ? One RCT (86 patients, ankle sprain): Diclofenac 150 mg/day statistically worse

2016 Tools for Practice

50. Topical NSAID

and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See for financial assistance information. Ontology: Diclofenac Topical Product (C0358504) Concepts Clinical Drug ( T200 ) SnomedCT 349350007 English Topical diclofenac , diclofenac topical , Diclofenac Topical Product , Topical form diclofenac (product) , Topical form diclofenac , Topical diclofenac (product) , Topical diclofenac (substance) Spanish (...) Topical NSAID Topical NSAID Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Topical NSAID Topical NSAID Aka: Topical NSAID

2018 FP Notebook

51. For Patients Undergoing Open-Flap Debridement Surgery, There is No Significant Difference Between Dexamethasone and NSAIDs For Reducing Patient Perceived Pain

periodontal surgery, what is the effect of dexamethasone on patient perceived pain as compared to traditional non-steroidal anti-inflammatories? Clinical Bottom Line Dexamethasone and NSAIDs are equally effective in reducing patient perceived pain following periodontal open flap debridement surgeries. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Steffens/2010 15 adult patients receiving periodontal surgery (...) Fields] AND "agents"[All Fields] AND "non-steroidal"[All Fields]) OR "non-steroidal anti-inflammatory agents"[All Fields] OR "nsaids"[All Fields]) AND periodontal[All Fields] AND ("surgery"[Subheading] OR "surgery"[All Fields] OR "surgical procedures, operative"[MeSH Terms] OR ("surgical"[All Fields] AND "procedures"[All Fields] AND "operative"[All Fields]) OR "operative surgical procedures"[All Fields] OR "surgery"[All Fields] OR "general surgery"[MeSH Terms] OR ("general"[All Fields] AND "surgery

2015 UTHSCSA Dental School CAT Library

52. Should Topical NSAIDs Be Used to Treat Acute Musculoskeletal Conditions?

the list of those included in this review. 7 This Cochrane review demonstrated that topical non- steroidal anti-in?ammatory drugs, com- pared with placebo, provide adequate Performance of topical nonsteroidal anti-in?ammatory drugs versus placebo in acute musculoskeletal injuries. Studies (Total No. of Patients) Treatment Bene?t,* RR (95% CI) Adverse Event, † RR (95% CI) I 2 ,% Topical NSAID vs placebo 31 (3,462) 1.5 (1.4–1.6) 1.1 (0.88–1.4) 74 RR, Relative risk; CI, con?dence interval; NSAID (...) topical salicylates were not in- cluded in this review because they are no longer classi?ed as topical nonsteroidal anti-in?ammatory drugs. Only patient-reported out- comes were included in this re- view and investigator-reported outcomes were not used. DATA EXTRACTION AND SYNTHESIS Quality of study methodology was assessed independently by 2 investiga- tors. Data comparing topical non- steroidal anti-in?ammatory drugs with placebo were analyzed with a ?xed-effects model and were ex- pressed

2011 Annals of Emergency Medicine Systematic Review Snapshots

53. NSAID-induced corneal melt: Clinical importance, pathogenesis, and risk mitigation. Full Text available with Trip Pro

NSAID-induced corneal melt: Clinical importance, pathogenesis, and risk mitigation. Corneal melt, an ophthalmological condition in which corneal epithelium is lost accompanied by thinning of the corneal stroma, can lead to corneal perforation and cause loss of vision. Corneal melt is the most serious side effect of topical nonsteroidal anti-inflammatory drugs (NSAIDs), one of the topical treatments of ocular inflammation. NSAID-induced corneal melt (NICM), initially doubted, is real, having (...) been reported by multiple groups. NICM is induced by all but one of the approved ocular NSAIDs and occurs usually in patients whose cornea is compromised by ocular surgery, diabetes, or autoimmune diseases. Its true incidence, most likely low, remains unknown. NSAID dose and duration of treatment may be important for NICM. NICM appears to evolve in two stages: the epithelial stage-marked by a corneal epithelial defect, reduced eicosanoid levels, leukocyte infiltration, and matrix metalloproteinase

2019 Survey of Ophthalmology

55. Post Implantation Syndrome and Administration on NSAIDs in Patients Undergoing EVAR for AAA

for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by Elena Arnaoutoglou, University of Thessaly: post implantation syndrome EVAR cardiovascular outcome NSAIDs Additional relevant MeSH terms: Layout table for MeSH terms Aneurysm Aortic Aneurysm, Abdominal Vascular Diseases Cardiovascular Diseases Aortic Aneurysm Aortic Diseases Naproxen Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory (...) available literature data certainly raise the question of altering current approach and treat patients with PIS by focusing on the reduction of the inflammatory response by administration of steroid or non-steroidal drugs. The aim of the present randomized placebo-controlled study is to evaluate whether the perioperative administration of Naproxen (NPR) an anti-inflammatory drug with a beneficial cardiovascular safety profile in patients with an abdominal aortic aneurysm undergoing endovascular repair

2018 Clinical Trials

56. Examining the Role of Improved NSAID Management in Treating Dysmenorrhea and Bladder Pain

Product: Yes Studies a U.S. FDA-regulated Device Product: No Product Manufactured in and Exported from the U.S.: Yes Keywords provided by Frank F. Tu, NorthShore University HealthSystem Research Institute: cross-organ sensitivity bladder pain NSAID visceral pain Additional relevant MeSH terms: Layout table for MeSH terms Dysmenorrhea Menstruation Disturbances Pathologic Processes Pelvic Pain Pain Neurologic Manifestations Signs and Symptoms Naproxen Anti-Inflammatory Agents, Non-Steroidal Analgesics (...) , Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anti-Inflammatory Agents Antirheumatic Agents Gout Suppressants Cyclooxygenase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action

2018 Clinical Trials

57. Effect of NSAIDs on Pupil Diameter and Expression of Aqueous Humor Cytokines in FLACS Versus Conventional Phacoemulsification. (Abstract)

Effect of NSAIDs on Pupil Diameter and Expression of Aqueous Humor Cytokines in FLACS Versus Conventional Phacoemulsification. To compare the concentrations of interleukin (IL) (IL-1b, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70), interferon (IFN)-γ, tumor necrosis factor (TNF)-α, and TNF-β in the aqueous humor of patients undergoing femtosecond laser-assisted cataract surgery (FLACS) and corneal mechanical paracentesis treated with two different topical nonsteroidal anti-inflammatory drugs (...) (NSAIDs): bromfenac and indomethacin.In this prospective, randomized controlled, single-center study, aqueous humor samples were obtained immediately after performing the femtosecond laser procedure or at the start of conventional phacoemulsification. Preoperatively, the FLACS groups were administered (once daily and four times daily, respectively) either topical bromfenac 0.09% (12 eyes) or indomethacin 0.1% (12 eyes). The corneal paracentesis bromfenac and indomethacin groups received the same

2018 Journal of Refractive Surgery Controlled trial quality: uncertain

58. The Effect of NSAID Pretreatment on Aqueous Humor Prostaglandin E2 Concentration in Eyes Undergoing Femtosecond Laser-Assisted Capsulotomy Full Text available with Trip Pro

The Effect of NSAID Pretreatment on Aqueous Humor Prostaglandin E2 Concentration in Eyes Undergoing Femtosecond Laser-Assisted Capsulotomy To assess aqueous humor concentration of prostaglandin E2 (PGE2) after capsulotomy creation using a femtosecond laser (FLAC) in patients pretreated with short-term topical ketorolac versus patients without pretreatment.This prospective study comprised consecutive patients scheduled to undergo cataract surgery using a femtosecond laser platform to perform (...) only capsulotomies. An identical protocol for preoperative mydriasis was used for all the eyes included in the study, while aqueous humor was extracted from the anterior chamber of all patients immediately after the initial side port incision. ELISA was performed to quantify aqueous humor PGE2. The patients were divided into 2 groups; in group 1, the patients received short-term topical ketorolac preoperatively, while the patients in group 2 did not receive NSAID pretreatment.Twenty eyes of 20

2018 Journal of ophthalmology Controlled trial quality: uncertain

59. Dry Needling and Spinal Manipulation vs. Interocclusal Appliance (Splint), NSAIDs and Joint Mobs for Temporomandibular Dysfunction

Joint Disorders Temporomandibular Joint Dysfunction Syndrome Musculoskeletal Diseases Craniomandibular Disorders Mandibular Diseases Jaw Diseases Muscular Diseases Stomatognathic Diseases Myofascial Pain Syndromes Diclofenac Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anti-Inflammatory Agents Antirheumatic Agents Cyclooxygenase Inhibitors Enzyme Inhibitors Molecular Mechanisms (...) : Interocclusal Appliance Drug: NSAIDs Other: TMJ Mobs Not Applicable Detailed Description: Patients with stress temporomandibular dysfunction will be randomized to receive 1-2 treatment sessions per week for up to 4 weeks ( up to 8 sessions total) of either: (1) dry needling and spinal manipulation or (2) Interocclusal appliance (splint), NSAIDs, temporomandibular joint mobilization. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 60

2018 Clinical Trials

60. Effect of NSAID Use on Pain and Opioid Consumption Following Distal Radius Fracture

: November 21, 2018 Last Update Posted : February 15, 2019 See Sponsor: University of Missouri-Columbia Information provided by (Responsible Party): Jay T. Bridgeman, MD, University of Missouri-Columbia Study Details Study Description Go to Brief Summary: Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, are excellent medications for providing pain control in certain patients. There is some data to suggest that NSAIDs can be used to reduce postoperative pain and narcotic use in patients (...) deaths. The amount of prescription opioids sold to pharmacies, hospitals, and doctors' offices has drastically risen, yet there had not been an overall change in the amount of pain that Americans reported. Deaths from prescription opioids—drugs like oxycodone, hydrocodone, and methadone—have more than quadrupled since 1999. Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to control both postoperative pain and pain associated with some orthopaedic injuries in children and adults

2018 Clinical Trials

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