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Topical NSAID

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21. Necrotizing Sialometaplasia of the Hard Palate in a Patient Treated with Topical Nonsteroidal Anti-Inflammatory Drug (Full text)

Necrotizing Sialometaplasia of the Hard Palate in a Patient Treated with Topical Nonsteroidal Anti-Inflammatory Drug Necrotizing sialometaplasia is a rare, benign, self-limiting, necrotizing process involving the minor salivary glands, mainly the mucoserous glands of the hard palate. It is thought to be the result of an ischemic event of the vasculature supplying the salivary gland lobules. Some predisposing factors such as smoking, use of alcohol, denture wearing, recent surgery, traumatic (...) injuries, respiratory infections, systemic diseases bulimia, and anorexia have been described. Herein we present a case of necrotizing sialometaplasia of the hard palate in a patient without known predisposing factors, in our opinion, resulting from the use of topical anti-inflammatory drug. After diagnosis, the patient underwent treatment with chlorhexidine gluconate and a full palatal acrylic guard to protect the exposed bone from food residues during meals. After the sixth week the lesion regressed.

2016 Case reports in dentistry PubMed abstract

22. Hot Topics in Primary Care: Nonsteroidal Anti- inflammatory Drugs and Cardiovascular Risk: Where Are We Today? (Abstract)

Hot Topics in Primary Care: Nonsteroidal Anti- inflammatory Drugs and Cardiovascular Risk: Where Are We Today? 26845017 2016 06 09 2016 02 05 1533-7294 64 12 Suppl 2015 Dec The Journal of family practice J Fam Pract Hot Topics in Primary Care: Nonsteroidal Anti- inflammatory Drugs and Cardiovascular Risk: Where Are We Today? S67-70 jfp_6412y Ruoff Gary G Clinical Professor of Family Medicine, Department of Family Practice, Michigan State University College of Medicine, Director of Clinical (...) Research, Westside Family Medical Center, Kalamazoo, MI, USA. eng Journal Article Research Support, Non-U.S. Gov't Review United States J Fam Pract 7502590 0094-3509 0 Anti-Inflammatory Agents, Non-Steroidal AIM IM Anti-Inflammatory Agents, Non-Steroidal adverse effects Cardiovascular Diseases chemically induced prevention & control Humans Primary Health Care methods Risk Assessment Risk Factors 2016 2 5 6 0 2016 2 6 6 0 2016 6 10 6 0 ppublish 26845017 jfp_6412y

2015 Journal of Family Practice

23. Topical NSAIDs versus Opioids for Acute Musculoskeletal Pain: A Review of the Clinical Effectiveness

the comparative clinical effectiveness of topical NSAIDs versus opioids could be identified. Tags anesthesia, administration, topical, anti-inflammatory agents, non-steroidal, musculoskeletal pain, musculoskeletal Files In Brief Published : June 28, 2017 Rapid Response Summary with Critical Appraisal Published : January 30, 2017 Related Content Follow us: © 2019 Canadian Agency for Drugs and Technologies in Health Get our newsletter: (...) -000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the comparative clinical effectiveness of topical NSAIDs versus opioids for the treatment of acute musculoskeletal pain? Key Message Compared with placebo, topical NSAIDs were effective in reducing pain from acute musculoskeletal conditions, such as sprains, strains or sport injuries. Adverse events were rare and were usually related to skin reactions. No evidence regarding

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

24. Adverse effects of topical nonsteroidal antiinflammatory drugs in older adults with osteoarthritis: a systematic literature review (Full text)

-steroidal anti-inflammatory drugs was safer than oral administration for osteoarthritis in older adults, but that many patients reported systemic adverse effects with topical agents. Reliance on a narrative synthesis, and some lack of reporting in the review process, means the reliability of these conclusions is unclear. Authors' objectives To systematically review literature on reported adverse effects associated with the use of topical non-steroidal anti-inflammatory drugs (NSAIDs) in older adults (...) with osteoarthritis. Searching MEDLINE (from 1950 to November 2009), Scopus, EMBASE, Web of Science, and the Cochrane Library were searched for relevant studies published in English. Search terms were reported. Abstracts from dissertations and American College of Rheumatology meetings were also searched. Bibliographies of reviews and individuals studies were scanned for further studies. Study selection Papers were excluded if they were obviously unrelated to topical non-steroidal anti-inflammatory drugs (NSAIDs

2010 DARE. PubMed abstract

25. COVID-19 rapid evidence summary: Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) for people with or at risk of COVID-19

COVID-19 rapid evidence summary: Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) for people with or at risk of COVID-19 COVID-19 rapid evidence summary: Long-term use of non- steroidal anti-inflammatory drugs (NSAIDs) for people with or at risk of COVID-19 Evidence summary Published: 21 May 2020 www.nice.org.uk/guidance/es25 pathways Key messages Key messages The content of this evidence review was up-to-date on 20 April 2020. See summaries of product characteristics (SPCs (...) ), British national formulary (BNF) or the MHRA or NICE websites for up-to-date information. In March 2020, the French Health Ministry issued advice to avoid using non-steroidal anti- inflammatory drugs (NSAIDs) to treat symptoms of COVID-19 because these medicines might aggravate the infection. In response to these concerns, NHS England issued a Central Alerting System (CAS) alert, in which the Medical Director, Professor Stephen Powis, gave interim advice that people who are currently on NSAIDs

2020 National Institute for Health and Clinical Excellence - Advice

26. Safety and Efficacy of Meloxicam Compared to Other Nonsteroidal Antiinflammatory Drugs (NSAIDs) in an Observational Cohort Study of Patients With Rheumatoid Arthritis, Osteoarthritis, Lumbago, Scapulohumeral Periarthritis, Neck, Shoulder and Arm Syndrome

Resource links provided by the National Library of Medicine related topics: related topics: available for: Groups and Cohorts Go to Group/Cohort Intervention/treatment Meloxicam Drug: Meloxicam Other NSAIDs Drug: Other Non Steroidal Anti-Inflammatory Drugs (NSAIDs) except etodolac Outcome Measures Go to Primary Outcome Measures : Incidence for adverse event of gastrointestinal disorder [ Time Frame: up to 6 months ] Secondary Outcome Measures : Incidence for adverse drug reaction of gastrointestinal (...) provided by (Responsible Party): Boehringer Ingelheim Study Details Study Description Go to Brief Summary: Study to assess the safety profile of meloxicam by comparing incidence of gastrointestinal adverse events of meloxicam with that of NSAID in the routine daily therapeutic situation. Condition or disease Intervention/treatment Arthritis, Rheumatoid Drug: Meloxicam Drug: Other Non Steroidal Anti-Inflammatory Drugs (NSAIDs) except etodolac Study Design Go to Layout table for study information Study

2014 Clinical Trials

27. Hot topic: Early postpartum treatment of commercial dairy cows with nonsteroidal antiinflammatory drugs increases whole-lactation milk yield. (Full text)

Hot topic: Early postpartum treatment of commercial dairy cows with nonsteroidal antiinflammatory drugs increases whole-lactation milk yield. Previous research has shown that postpartum administration of the nonsteroidal antiinflammatory drug (NSAID) sodium salicylate can increase 305-d milk yield in older dairy cattle (parity 3 and greater). However, in this prior work, sodium salicylate was delivered to cows via the drinking water, a method that does not align well with current grouping (...) strategies on commercial dairy farms. The objective of the current study was to replicate these results on a commercial dairy farm with a simplified treatment protocol and to compare sodium salicylate with another NSAID, meloxicam. Dairy cattle in their second lactation and greater (n=51/treatment) were alternately assigned to 1 of 3 treatments at parturition, with treatments lasting for 3d. Experimental treatments began 12 to 36 h after parturition and were (1) 1 placebo bolus on the first day and 3

2015 Journal of dairy science Controlled trial quality: uncertain PubMed abstract

28. Analgesic effect of preoperative topical nonsteroidal antiinflammatory drugs on postoperative pain after laser-assisted subepithelial keratectomy. (Abstract)

Analgesic effect of preoperative topical nonsteroidal antiinflammatory drugs on postoperative pain after laser-assisted subepithelial keratectomy. To assess the effect of preoperative topical nonsteroidal antiinflammatory drugs (NSAIDs) on postoperative pain after laser-assisted subepithelial keratectomy (LASEK) and to investigate their mechanism.Severance Eye Hospital and Saeyan Eye Clinic, Seoul, South Korea.Prospective randomized clinical trial.Participants in 2 related studies were assessed (...) postoperatively (P < .05). The mean corneal sensitivity was statistically significantly lower in the NSAID-treated eye than in the placebo-treated eye at 1 and 2 hours in Groups 2A and 2C (P < .05).Preoperative administration of topical NSAIDs before LASEK effectively reduces postoperative pain.No author has a financial or proprietary interest in any material or method mentioned.Copyright © 2015 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

2015 Journal of cataract and refractive surgery Controlled trial quality: uncertain

29. Use of Non Steroidal Antiinflammatory Drugs in Patients With Community Acquired Pneumonia

Louis Mourier Information provided by (Responsible Party): Prof Jean-Damien RICARD, Hôpital Louis Mourier Study Details Study Description Go to Brief Summary: To investigate exposure to nonsteroidal antiinflammatory drugs (NSAIDs) during outpatient management at the early stage of community-acquired pneumonia (CAP) requiring hospital consultation. Non-interventional observational study. Condition or disease Community-acquired Pneumonia Detailed Description: Recent data suggests that such exposure (...) will be investigated. Clinical, biological and radioloigcal features and outcome of CAP will be compared with respect to NSAIDs exposure. Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 181 participants Observational Model: Cohort Time Perspective: Prospective Official Title: Descriptive Analysis of Non Steroidal Antiinflammatory Drugs Use in Patients Diagnosed With Community Acquired Pneumonia Study Start Date : November 2013 Actual Primary Completion Date

2015 Clinical Trials

30. Balancing cardiovascular and gastrointestinal risks in nonsteroidal anti-inflammatory drugs use in patients with osteoarthritis: guidelines summary from an international expert group addressing. (Abstract)

Balancing cardiovascular and gastrointestinal risks in nonsteroidal anti-inflammatory drugs use in patients with osteoarthritis: guidelines summary from an international expert group addressing. Over the past 2 decades, extensive research has assessed the use of traditional nonsteroidal antiinflammatory drugs (NSAIDs), and the newer cyclooxygenase‑2 (COX-2) inhibitor drugs, in the treatment of chronic pain syndromes. The proper use of NSAIDs has been the subject of significant debate, bringing (...) in making evidence‑based and individualized selections of NSAIDs. This review will discuss and summarize the most recent evidence on this topic to give an insight into the most effective and safest therapeutic options, thus preventing serious adverse CV and GI events. NSAIDs should be used cautiously and as infrequently as possible, with nonpharmacological approaches prescribed first. If the use of NSAIDs is required, the choice should balance the possible CV and GI risks.

2016 Polskie Archiwum Medycyny Wewnetrznej

31. Are Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) safe in the context of the COVID-19 pandemic?

Are Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) safe in the context of the COVID-19 pandemic? COVID-19 Scientific Advisory Group Rapid Response Report April 22, 2020 © 2020, Alberta Health Services, COVID-19 Scientific Advisory Group Key Research Topic: Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in COVID-19 Patients 1. Should patients who are on prescribed NSAIDS as chronic therapy stop taking these drugs if they develop COVID-19? 2. Should NSAIDs be used for anti-pyretic therapy (...) . or Sars-Cov- 2019.mp. or SarsCov-2019.mp. or "severe acute respiratory syndrome cov 2".mp. or "2019 ncov".mp. or "2019ncov".mp. 23331 2 exp Anti-Inflammatory Agents, Non-Steroidal/ 196204 3 antipyretics/ 2654 4 (anti-inflammatory analgesic* or anti-inflammatory agent* or aspirin like agent* or nsaids or nsaid or antiinflammatory agent* or anti-inflammatory drug* or aspirin like drug* or nsaids or nsaid or antiinflammatory drug*).kf,tw. 63319 5 ("4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3

2020 Covid-19 Ad hoc papers

32. Topical NSAIDs for chronic musculoskeletal pain in adults. (Full text)

Topical NSAIDs for chronic musculoskeletal pain in adults. Use of topical nonsteroidal anti-inflammatory drugs (NSAIDs) to treat chronic musculoskeletal conditions has become widely accepted because they can provide pain relief without associated systemic adverse events. This review is an update of 'Topical NSAIDs for chronic musculoskeletal pain in adults', originally published in Issue 9, 2012.To review the evidence from randomised, double-blind, controlled trials on the efficacy and safety (...) of topically applied NSAIDs for chronic musculoskeletal pain in adults.We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, and our own in-house database; the date of the last search was February 2016. We also searched the references lists of included studies and reviews, and sought unpublished studies by asking personal contacts and searching online clinical trial registers and manufacturers' web sites.We included randomised, double-blind, active or inert carrier

2016 Cochrane PubMed abstract

33. Topical NSAIDs for acute musculoskeletal pain in adults. (Full text)

an NNT of 2.5 (2.0 to 3.4), from five studies in the 1980s, some with less well defined outcomes. Ibuprofen gel had an NNT of 3.9 (2.7 to 6.7) from two studies with outcomes of marked improvement or complete remission. All other drug and formulation combinations had NNT values above 4, indicating lesser efficacy.There were insufficient data to compare reliably individual topical NSAIDs with each other or the same oral NSAID.Local skin reactions were generally mild and transient, and did not differ (...) Topical NSAIDs for acute musculoskeletal pain in adults. Use of topical NSAIDs to treat acute musculoskeletal conditions has become widely accepted because they can provide pain relief without associated systemic adverse events. This review is an update of 'Topical NSAIDs for acute pain in adults' originally published in Issue 6, 2010.To determine the efficacy and safety of topically applied NSAIDs in acute musculoskeletal pain in adults.We searched the Cochrane Register of Studies Online

2015 Cochrane PubMed abstract

34. Effect of Topical Nonsteroidal Anti-Inflammatory Drugs and Nuclear Hardness on Maintenance of Mydriasis During Phacoemulsification Surgery. (Abstract)

Effect of Topical Nonsteroidal Anti-Inflammatory Drugs and Nuclear Hardness on Maintenance of Mydriasis During Phacoemulsification Surgery. To compare the effects of topical nonsteroidal anti-inflammatory drugs on pupil dilation maintenance during phacoemulsification cataract surgery and quantify the relationships between pupil size change and nuclear hardness.This prospective randomized clinical observation study was single centered and double-masked. We studied 239 cases undergoing uneventful

2014 Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics Controlled trial quality: uncertain

35. Systematic review with meta-analysis: Topical NSAIDS provide effective pain relief for patients with hand or knee osteoarthritis with similar efficacy, and fewer side effects, than oral NSAIDS (Full text)

Systematic review with meta-analysis: Topical NSAIDS provide effective pain relief for patients with hand or knee osteoarthritis with similar efficacy, and fewer side effects, than oral NSAIDS Topical NSAIDS provide effective pain relief for patients with hand or knee osteoarthritis with similar efficacy, and fewer side effects, than oral NSAIDS | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie (...) settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Topical NSAIDS provide effective pain

2013 Evidence-Based Medicine PubMed abstract

36. NSAIDs

contact us via jon.brassey@tripdatabase.com Top results for nsaids 1. Topical NSAIDs : good relief for acute musculoskeletal pain Topical NSAIDs : good relief for acute musculoskeletal pain - Evidently Cochrane Search and hit Go By June 25, 2015 // Non-steroidal anti-inflammatory drugs ( NSAIDs ) are routinely prescribed for mild to moderate pain and are the most commonly prescribed painkilling drugs worldwide. Taken by mouth or injected into a vein, the high concentrations of the drug throughout (...) with hand or knee osteoarthritis with similar efficacy, and fewer side effects, than oral NSAIDS Article Text 2013 6. NSAIDs : Are They All the Same? NSAIDs : Are They All the Same? | Clinical Correlations NSAIDs : Are They All the Same? February 1, 2018 By Vishal Shah, MD Peer Reviewed Nonsteroidal antiinflammatory drugs ( NSAIDs ) are a heterogenous group of non-opioid analgesics and anti-inflammatory agents. Their use is ubiquitous, from treating a simple tension headache to a sprained ankle. NSAIDs

2018 Trip Latest and Greatest

37. Systematic review: Topical NSAIDs significantly reduces pain in adults with acute musculoskeletal injuries

Systematic review: Topical NSAIDs significantly reduces pain in adults with acute musculoskeletal injuries Topical NSAIDs significantly reduces pain in adults with acute musculoskeletal injuries | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts (...) OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Topical NSAIDs significantly reduces pain in adults with acute musculoskeletal injuries Article Text Therapeutics/Prevention Systematic review Topical NSAIDs significantly reduces pain in adults

2016 Evidence-Based Medicine

38. Topical NSAIDs: good relief for acute musculoskeletal pain

Topical NSAIDs: good relief for acute musculoskeletal pain Topical NSAIDs: good relief for acute musculoskeletal pain - Evidently Cochrane Search and hit Go By June 25, 2015 // Non-steroidal anti-inflammatory drugs (NSAIDs) are routinely prescribed for mild to moderate pain and are the most commonly prescribed painkilling drugs worldwide. Taken by mouth or injected into a vein, the high concentrations of the drug throughout the body, necessary in order to work at the site of pain (...) that topical NSAIDs are an effective and safe means of relieving acute musculoskeletal pain in adults. The new evidence also tells us much more than we knew before about which ones work best. The evidence comes from 61 randomized controlled trials (RCTs) with 8386 people. Several different topical NSAIDs were compared, mostly with placebo in the same carrier – so gel with a drug compared to the gel without a drug, for example. Both would be rubbed into the skin so we know that any effect is not just from

2015 Evidently Cochrane

39. Should non-selective non-steroidal anti-inflammatory drugs (NSAIDs) be avoided following dermatologic surgery? A critically appraised topic with a proposed approach to post-operative analgesia. (Abstract)

Should non-selective non-steroidal anti-inflammatory drugs (NSAIDs) be avoided following dermatologic surgery? A critically appraised topic with a proposed approach to post-operative analgesia. Non-selective non-steroidal anti-inflammatory drugs (NSAIDs) are often avoided by dermatologic surgeons from the historic teaching that they increase post-operative bleeding (POB) through inhibition of platelet aggregation. NSAIDs have two classes: non-selective which inhibit all cyclooxygenase (COX (...) ) enzymes and selective COX2 inhibitors. Non-selective NSAIDs increase bleeding time by inhibition of the COX1 enzyme resulting in decreased thromboxane A2; a vasoconstrictor and vital for platelet aggregation. COX2 inhibitors act differently and pose no bleeding risk. Aspirin inhibits the enzyme irreversibly for the platelet's lifetime. Other NSAIDs are reversible, with effects dependent on dose, half-life. We critically appraised the evidence assessing non-selective NSAIDs (excluding aspirin) effect

2019 Clinical & Experimental Dermatology

40. Misoprostol for Small Bowel Ulcers and Obscure Bleeding Due to Aspirin or Nonsteroidal Antiinflammatory Drugs

Last Update Posted : August 14, 2018 Sponsor: NHS Greater Glasgow and Clyde Information provided by (Responsible Party): NHS Greater Glasgow and Clyde Study Details Study Description Go to Brief Summary: Anti-inflammatory tablets (non-steroidal anti-inflammatory drugs) continue to be used commonly worldwide to relieve pain caused by arthritis. Likewise, aspirin is used by many patients in order to prevent blood clots. Despite their desired benefits, these medicines can cause internal bleeding from (...) Processes Vascular Diseases Coronary Disease Arteriosclerosis Arterial Occlusive Diseases Aspirin Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents Misoprostol Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Antirheumatic Agents Fibrinolytic Agents Fibrin Modulating Agents Molecular Mechanisms of Pharmacological Action Platelet Aggregation Inhibitors Cyclooxygenase Inhibitors Enzyme Inhibitors Antipyretics

2014 Clinical Trials

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