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Topical Corticosteroid

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121. Guidelines for the Diagnosis and Management of Critical Illness-Related Corticosteroid Insufficiency (CIRCI) in Critically Ill Patients (Part II)

at Annual Meeting, the European Society of Intensive Care Medicine (EISCM) (co-chair of Corticosteroid Guideline in collaboration with SCCM), and the Korean Society of Critical Care Medicine (co-director and speaker at Multiprofessional Critical Care Board Review Course). He has spoken on the topic of corticosteroid use in critical illness and specifically in sepsis at the International Symposium in Critical and Emergency Medicine in March 2017. Dr. Annane has been involved with research relating (...) Guidelines for the Diagnosis and Management of Critical Illness-Related Corticosteroid Insufficiency (CIRCI) in Critically Ill Patients (Part II) Guidelines for the Diagnosis and Management of Critical Illn... : Critical Care Medicine You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page. Login No user account? Lippincott Journals Subscribers , use your username or email along with your password to log in. Remember me

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2018 Society of Critical Care Medicine

122. Corticosteroids Provide Better Postoperative Endodontic Pain Relief Compared to Placebo (CAT#3350)

Corticosteroids Provide Better Postoperative Endodontic Pain Relief Compared to Placebo (CAT#3350) UTCAT3350, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Corticosteroids Provide Better Postoperative Endodontic Pain Relief Compared to Placebo Clinical Question In patients receiving non-surgical endodontic therapy, do corticosteroids provide better postoperative endodontic pain relief compared to placebo? Clinical (...) and dosages of corticosteroids produced different levels of analgesic efficacy. The three main types of corticosteroids studied in this article were prednisolone, dexamethasone, and betamethasone. At 6 hours, prednisolone had a more significant effect on pain relief than the other two drugs due to faster onset. It is speculated that this was because prednisolone has a shorter half-life and diffuses across the cell membrane at a faster rate to affect gene transcription. Applicability This topic

2018 UTHSCSA Dental School CAT Library

123. Corticosteroid implants for chronic non-infectious uveitis. (PubMed)

Corticosteroid implants for chronic non-infectious uveitis. Uveitis is a term used to describe a heterogeneous group of intraocular inflammatory diseases of the anterior, intermediate, and posterior uveal tract (iris, ciliary body, choroid). Uveitis is the fifth most common cause of vision loss in high-income countries, accounting for 5% to 20% of legal blindness, with the highest incidence of disease in the working-age population.Corticosteroids are the mainstay of acute treatment for all (...) anatomical subtypes of non-infectious uveitis and can be administered orally, topically with drops or ointments, by periocular (around the eye) or intravitreal (inside the eye) injection, or by surgical implantation.To determine the efficacy and safety of steroid implants in people with chronic non-infectious posterior uveitis, intermediate uveitis, and panuveitis.We searched CENTRAL (which contains the Cochrane Eyes and Vision Trials Register) (Issue 10, 2015), Ovid MEDLINE, Ovid MEDLINE In-Process

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2016 Cochrane

124. Different oral corticosteroid regimens for acute asthma. (PubMed)

Different oral corticosteroid regimens for acute asthma. Asthma is a common long-term breathing condition that affects approximately 300 million people worldwide. People with asthma may experience short-term worsening of their asthma symptoms; these episodes are often known as 'exacerbations', 'flare-ups', 'attacks' or 'acute asthma'. Oral steroids, which have a potent anti-inflammatory effect, are recommended for all but the most mild asthma exacerbations; they should be initiated promptly (...) . The most often prescribed oral steroids are prednisolone and dexamethasone, but current guidelines on dosing vary between countries, and often among different guideline producers within the same country. Despite their proven efficacy, use of steroids needs to be balanced against their potential to cause important adverse events. Evidence is somewhat limited regarding optimal dosing of oral steroids for asthma exacerbations to maximise recovery while minimising potential side effects, which is the topic

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2016 Cochrane

125. Moisturisers improve eczema symptoms and lessen the need for corticosteroids

score, mean difference [MD] -2.42 (95% confidence interval [CI] -4.55 to -0.28; three studies, 276 participants). However, the change was not considered clinically significant. Fewer people using moisturisers had flares, 27% compared to 67% not using moisturisers over six month follow up (risk ratio [RR] 0.40, 95% CI 0.23 to 0.70; two studies, 87 participants). Time between flares was prolonged with moisturisers (median of 180 versus 30 days). Less topical corticosteroids were needed for people (...) to the SCORAD score, mean difference [MD] -2.42 (95% confidence interval [CI] -4.55 to -0.28; three studies, 276 participants). However, the change was not considered clinically significant. Fewer people using moisturisers had flares, 27% compared to 67% not using moisturisers over six month follow up (risk ratio [RR] 0.40, 95% CI 0.23 to 0.70; two studies, 87 participants). Time between flares was prolonged with moisturisers (median of 180 versus 30 days). Less topical corticosteroids were needed

2019 NIHR Dissemination Centre

126. Corticosteroid injections provide only short term relief for rotator cuff disorders

the widespread use of corticosteroid injections, past trials have had mixed findings and their use continues to be debated. The last review on the topic was conducted in 2010, and since then four new trials have been published. What did this study do? This systematic review and meta-analysis identified 11 randomised controlled trials including 726 adults with rotator cuff disorders. One of the trials compared corticosteroid injection with placebo injection of salt water, and the remaining trials compared (...) to treat pain. Despite the widespread use of corticosteroid injections, past trials have had mixed findings and their use continues to be debated. The last review on the topic was conducted in 2010, and since then four new trials have been published. What did this study do? This systematic review and meta-analysis identified 11 randomised controlled trials including 726 adults with rotator cuff disorders. One of the trials compared corticosteroid injection with placebo injection of salt water

2019 NIHR Dissemination Centre

127. Guidelines for the Diagnosis and Management of Critical Illness-Related Corticosteroid Insufficiency (CIRCI) in Critically Ill Patients (Part I)

): Moderator at Annual Meeting, the European Society of Intensive Care Medicine (EISCM) (co-chair of Corticosteroid Guideline in collaboration with SCCM), and the Korean Society of Critical Care Medicine (co-director and speaker at Multiprofessional Critical Care Board Review Course). He has spoken on the topic of corticosteroid use in critical illness and specifically in sepsis at the International Symposium in Critical and Emergency Medicine in March 2017. Dr. Arlt participates in the Society (...) Guidelines for the Diagnosis and Management of Critical Illness-Related Corticosteroid Insufficiency (CIRCI) in Critically Ill Patients (Part I) Guidelines for the Diagnosis and Management of Critical Illn... : Critical Care Medicine You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page. Login No user account? Lippincott Journals Subscribers , use your username or email along with your password to log in. Remember me

2017 Society of Critical Care Medicine

128. Antenatal Corticosteroid Therapy for Fetal Maturation

corticosteroids use for infants born before 34 weeks of gestation and timing of corticosteroids in relation to delivery will support quality improvement efforts to optimize appropriate and timely antenatal corticosteroid administration. For More Information The American College of Obstetricians and Gynecologists has identified additional resources on topics related to this document that may be helpful for ob-gyns, other health care providers, and patients. You may view these resources at . These resources (...) Antenatal Corticosteroid Therapy for Fetal Maturation Antenatal Corticosteroid Therapy for Fetal Maturation - ACOG Menu ▼ Antenatal Corticosteroid Therapy for Fetal Maturation Page Navigation ▼ INTERIM UPDATE A correction was published in November 2017 for this title. Click to view the correction. Number 713, August 2017 (Replaces Committee Opinion No. 677, October 2016) (Reaffirmed 2018) Committee on Obstetric Practice This Committee Opinion was developed by the American College

2017 American College of Obstetricians and Gynecologists

129. Corticosteroids - topical (skin), nose, and eyes

Corticosteroids - topical (skin), nose, and eyes Corticosteroids - topical (skin), nose, and eyes - NICE CKS Clinical Knowledge Summaries Share Corticosteroids - topical (skin), nose, and eyes: Summary Corticosteroids are synthetic analogues of the natural hormones that are produced by the adrenal cortex. Local corticosteroids are predominantly glucocorticoids. They have 4 main effects: Anti-inflammatory. Immunosuppressive. Anti-proliferative (anti-mitotic). Vasoconstrictive. Topical (...) , or infection. The length of treatment with topical corticosteroids depends on the diagnosis. Generally, very potent corticosteroids should not be used for more than 3 weeks continuously. If treatment is indicated for longer, intermittent dosing and gradual tapering of the dose should be considered, and more frequent monitoring for adverse effects should be arranged. Less potent topical corticosteroids can be used for up to 3 months, except in intertriginous areas, on the face and neck, or under occlusion

2015 NICE Clinical Knowledge Summaries

130. Study to Evaluate the Efficacy and Safety of Tezepelumab in Reducing Oral Corticosteroid Use in Adults With Oral Corticosteroid Dependent Asthma

Use in Adults With Oral Corticosteroid Dependent Asthma (SOURCE) Actual Study Start Date : March 5, 2018 Estimated Primary Completion Date : November 26, 2020 Estimated Study Completion Date : November 26, 2020 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Tezepelumab Tezepelumab subcutaneous injection Biological: Tezepelumab Tezepelumab subcutaneous injection Placebo Comparator: Placebo Placebo (...) Study to Evaluate the Efficacy and Safety of Tezepelumab in Reducing Oral Corticosteroid Use in Adults With Oral Corticosteroid Dependent Asthma Study to Evaluate the Efficacy and Safety of Tezepelumab in Reducing Oral Corticosteroid Use in Adults With Oral Corticosteroid Dependent Asthma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save

2018 Clinical Trials

131. A Study Comparing Corticosteroids Alone Versus Corticosteroids and Extracorporal Photopheresis (ECP) as First-line Treatment of Standard II Acute Graft-versus-host Disease

Photopheresis (ECP) as First-line Treatment of Standard Risk Grade II Acute Graft-versus-host Disease After Allogeneic Stem Cell Transplantation Estimated Study Start Date : October 1, 2018 Estimated Primary Completion Date : April 1, 2021 Estimated Study Completion Date : April 1, 2022 Resource links provided by the National Library of Medicine related topics: available for: resources: Arms and Interventions Go to Arm Intervention/treatment Experimental: Experimental group corticosteroids + ECP Combination (...) A Study Comparing Corticosteroids Alone Versus Corticosteroids and Extracorporal Photopheresis (ECP) as First-line Treatment of Standard II Acute Graft-versus-host Disease A Study Comparing Corticosteroids Alone Versus Corticosteroids and Extracorporal Photopheresis (ECP) as First-line Treatment of Standard II Acute Graft-versus-host Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search

2018 Clinical Trials

132. Corticosteroid(CS) + Lido or Corticosteroid(CS) Alone

: Treatment Official Title: Corticosteroid(CS) Injections for the Treatment of Common Upper Extremity Pathologies, With or Without Lidocaine Estimated Study Start Date : March 2019 Estimated Primary Completion Date : August 2021 Estimated Study Completion Date : August 2021 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Treatment Group (corticosteroid injection plus lidocaine) Treatment (...) Corticosteroid(CS) + Lido or Corticosteroid(CS) Alone Corticosteroid(CS) + Lido or Corticosteroid(CS) Alone - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Corticosteroid(CS) + Lido or Corticosteroid(CS

2018 Clinical Trials

133. A double-blind randomised placebo controlled trial of topical intranasal corticosteroids in 4- to11-year-old children with persistent bilateral otitis media with effusion in primary care

A double-blind randomised placebo controlled trial of topical intranasal corticosteroids in 4- to11-year-old children with persistent bilateral otitis media with effusion in primary care A double-blind randomised placebo controlled trial of topical intranasal corticosteroids in 4- to11-year-old children with persistent bilateral otitis media with effusion in primary care Journals Library An error has occurred in processing the XML document An error occurred retrieving content to display, please (...) try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} Study found that the use of topical intranasal corticosteroids is very unlikely to be a clinically effective treatment for otitis media with effusion in children in the primary care

2009 NIHR HTA programme

134. Comparison of Topical Latanoprost vs Topical Corticosteroid in Treatment of Localized Alopecia Areata

Comparison of Topical Latanoprost vs Topical Corticosteroid in Treatment of Localized Alopecia Areata Comparison of Topical Latanoprost vs Topical Corticosteroid in Treatment of Localized Alopecia Areata - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Comparison of Topical Latanoprost vs Topical Corticosteroid in Treatment of Localized Alopecia Areata (COLA) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02350023 Recruitment Status : Completed First Posted : January 29, 2015 Last Update Posted

2015 Clinical Trials

135. A retrospective analysis of pediatric patients with lichen sclerosus treated with a standard protocol of class I topical corticosteroid and topical calcineurin inhibitor. (PubMed)

A retrospective analysis of pediatric patients with lichen sclerosus treated with a standard protocol of class I topical corticosteroid and topical calcineurin inhibitor. Lichen sclerosus (LS) is a chronic, inflammatory condition of the skin, affecting primarily the anogenital region potentially leading to changes in vaginal architecture and vulvar squamous cell carcinoma. Current recommended treatment for LS is high-potency corticosteroids. Calcineurin inhibitors may also have a role.The (...) objective of this study is to introduce a treatment regimen involving clobetasol to induce remission, then tacrolimus to maintain remission in pediatric females with LS.As a retrospective case series, we report 14 pediatric females between 2 and 10 years of age with LS treated with clobetasol 0.05% topical ointment and systematically bridged to tacrolimus 0.1% topical ointment. For each patient, gender, age at disease onset, and clinical symptoms and features were noted. Time in weeks to 75% clearance

2015 Journal of Dermatological Treatment

136. Systemic and topical antibiotics for chronic rhinosinusitis. (PubMed)

Systemic and topical antibiotics for chronic rhinosinusitis. This review is one of six looking at the primary medical management options for patients with chronic rhinosinusitis.Chronic rhinosinusitis is common and is characterised by inflammation of the lining of the nose and paranasal sinuses leading to nasal blockage, nasal discharge, facial pressure/pain and loss of sense of smell. The condition can occur with or without nasal polyps. Systemic and topical antibiotics are used with the aim (...) of eliminating infection in the short term (and some to reduce inflammation in the long term), in order to normalise nasal mucus and improve symptoms.To assess the effects of systemic and topical antibiotics in people with chronic rhinosinusitis.The Cochrane ENT Information Specialist searched the Cochrane ENT Trials Register; CENTRAL (2015, Issue 8); MEDLINE; EMBASE; ClinicalTrials.gov; ICTRP and additional sources for published and unpublished trials. The date of the search was 29 September 2015.Randomised

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2016 Cochrane

137. Topical treatments for scalp psoriasis. (PubMed)

for continuous outcomes. If studies were sufficiently homogeneous, we meta-analysed the data by using the random-effects model. Where it was not possible to calculate a point estimate for a single study, we described the data qualitatively. We also presented the number needed to treat to benefit (NNTB).We categorised topical corticosteroids according to the German classification of corticosteroid potency as mild, moderate, high and very high.We included 59 RCTs with a total of 11,561 participants. Thirty (...) that the two-compound combination, steroids and vitamin D monotherapy were more effective than the vehicle. Steroids of moderate, high and very high potency tended to be similarly effective and well tolerated. There are inherent limitations in this review concerning the evaluation of salicylic acid, tar, dithranol or other topical treatments.The two-compound combination as well as corticosteroid monotherapy were more effective and safer than vitamin D monotherapy. Given the similar safety profile and only

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2016 Cochrane

138. Moisturisers improve eczema symptoms and lessen the need for corticosteroids

score, mean difference [MD] -2.42 (95% confidence interval [CI] -4.55 to -0.28; three studies, 276 participants). However, the change was not considered clinically significant. Fewer people using moisturisers had flares, 27% compared to 67% not using moisturisers over six month follow up (risk ratio [RR] 0.40, 95% CI 0.23 to 0.70; two studies, 87 participants). Time between flares was prolonged with moisturisers (median of 180 versus 30 days). Less topical corticosteroids were needed for people (...) to the SCORAD score, mean difference [MD] -2.42 (95% confidence interval [CI] -4.55 to -0.28; three studies, 276 participants). However, the change was not considered clinically significant. Fewer people using moisturisers had flares, 27% compared to 67% not using moisturisers over six month follow up (risk ratio [RR] 0.40, 95% CI 0.23 to 0.70; two studies, 87 participants). Time between flares was prolonged with moisturisers (median of 180 versus 30 days). Less topical corticosteroids were needed

2018 NIHR Dissemination Centre

139. Corticosteroid injections provide only short term relief for rotator cuff disorders

the widespread use of corticosteroid injections, past trials have had mixed findings and their use continues to be debated. The last review on the topic was conducted in 2010, and since then four new trials have been published. What did this study do? This systematic review and meta-analysis identified 11 randomised controlled trials including 726 adults with rotator cuff disorders. One of the trials compared corticosteroid injection with placebo injection of salt water, and the remaining trials compared (...) to treat pain. Despite the widespread use of corticosteroid injections, past trials have had mixed findings and their use continues to be debated. The last review on the topic was conducted in 2010, and since then four new trials have been published. What did this study do? This systematic review and meta-analysis identified 11 randomised controlled trials including 726 adults with rotator cuff disorders. One of the trials compared corticosteroid injection with placebo injection of salt water

2018 NIHR Dissemination Centre

140. Saline irrigation and corticosteroid spray are effective first choice treatments for chronic sinusitis

SMD indicates improvement). Topical corticosteroid therapy improved overall symptom scores (SMD, -0.46 [95% CI, -0.65 to -0.27]; a negative SMD indicates improvement), improved polyp scores (SMD, -0.73 [95% CI, -1.0 to -0.46]; a negative SMD indicates improvement), and reduced polyp recurrence after surgery (relative risk, 0.59 [95% CI, 0.45 to 0.79]). Systemic corticosteroids and oral doxycycline (both for 3 weeks) reduced polyp size compared with placebo for 3 months after treatment (P < .001 (...) ). Leukotriene antagonists improved nasal symptoms compared with placebo in patients with nasal polyps (P < .01). Macrolide antibiotic for 3 months was associated with improved QOL at a single time point (24 weeks after therapy) compared with placebo for patients without polyps (SMD, -0.43 [95% CI, -0.82 to -0.05]). CONCLUSIONS AND RELEVANCE: Evidence supports daily high-volume saline irrigation with topical corticosteroid therapy as a first-line therapy for chronic sinusitis. A short course of systemic

2018 NIHR Dissemination Centre

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