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Topical Corticosteroid

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81. Antenatal Corticosteroid Therapy for Improving Neonatal Outcomes

Institutes of Health, the American College of Obstetricians and Gynecologists, the Society for Maternal Fetal Medicine, the Royal College of Obstetricians and Gynaecologists, and the Canadian Pediatric Society were reviewed for additional references. Randomized controlled trials conducted in pregnant women evaluating antenatal corticosteroid therapy and previous systematic reviews on the topic were eligible. Evidence from systematic reviews of non-experimental (cohort) studies was also eligible (...) Antenatal Corticosteroid Therapy for Improving Neonatal Outcomes No. 364-Antenatal Corticosteroid Therapy for Improving Neonatal Outcomes - Journal of Obstetrics and Gynaecology Canada Email/Username: Password: Remember me Search Terms Search within Search Volume 40, Issue 9, Pages 1219–1239 No. 364-Antenatal Corticosteroid Therapy for Improving Neonatal Outcomes x Amanda Skoll , MD * Vancouver, BC x Amélie Boutin , PhD * Québec City, QC x Emmanuel Bujold , MD, MSc Québec City, QC x Jason

2018 Society of Obstetricians and Gynaecologists of Canada

82. Corticosteroids

. If you wanted the latest trusted evidence on corticosteroids or other clinical topics then use Trip today. This page lists the very latest high quality evidence on corticosteroids and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months. What is Trip? Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice (...) Corticosteroids Top results for corticosteroids - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3

2018 Trip Latest and Greatest

83. Inhaled versus systemic corticosteroids for the treatment of bronchopulmonary dysplasia in ventilated very low birth weight preterm infants. (PubMed)

of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome. Due to their anti-inflammatory properties, corticosteroids have been widely used to treat or prevent BPD. However, the use of systemic steroids has been associated with serious short- and long-term adverse effects. Administration of corticosteroids topically through the respiratory tract may result in beneficial effects on the pulmonary system with fewer undesirable systemic side (...) Inhaled versus systemic corticosteroids for the treatment of bronchopulmonary dysplasia in ventilated very low birth weight preterm infants. This is an update of a review published in 2012. A related review "Inhaled versus systemic corticosteroids for preventing bronchopulmonary dysplasia in ventilated very low birth weight preterm neonates" has been updated as well. Bronchopulmonary dysplasia (BPD) is a serious and common problem among very low birth weight infants, despite the use

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2017 Cochrane

84. Non-steroidal anti-inflammatory drugs versus corticosteroids for controlling inflammation after uncomplicated cataract surgery. (PubMed)

, but these two drug classes work by different mechanisms. Corticosteroids are effective, but NSAIDs may provide an additional benefit to reduce inflammation when given in combination with corticosteroids. A comparison of NSAIDs to corticosteroids alone or combination therapy with these two anti-inflammatory agents will help to determine the role of NSAIDs in controlling inflammation after routine cataract surgery.To evaluate the comparative effectiveness of topical NSAIDs (alone or in combination (...) with topical corticosteroids) versus topical corticosteroids alone in controlling intraocular inflammation after uncomplicated phacoemulsification. To assess postoperative best-corrected visual acuity (BCVA), patient-reported discomfort, symptoms, or complications (such as elevation of IOP), and cost-effectiveness with the use of postoperative NSAIDs or corticosteroids.To identify studies relevant to this review, we searched the Cochrane Central Register of Controlled Trials (CENTRAL), which contains

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2017 Cochrane

85. Proliferative and necrotizing otitis externa in a kitten: successful treatment with intralesional and topical corticosteroid therapy (PubMed)

Proliferative and necrotizing otitis externa in a kitten: successful treatment with intralesional and topical corticosteroid therapy Proliferative and necrotising otitis externa (PNOE) is a very rare disease affecting the ear canals and concave pinnae of kittens. This report describes a 5-month-old cat with PNOE. Histopathological examination confirmed the diagnosis. Treatment was initiated with local injection of methylprednisolone acetate into the lesions. The cat was subsequently treated (...) with clobetasol propionate cream, a potent topical glucocorticoid ointment. The cat showed marked improvement. While topical treatment with tacrolimus, an immunosuppressive agent, is reported to be an effective therapy, to the best of our knowledge, this is the first report to treat PNOE with local corticosteroid therapy.

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2016 The Journal of Veterinary Medical Science

86. Topical Corticosteroid App

Topical Corticosteroid App Topical Corticosteroid App - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Topical Corticosteroid App The safety and scientific validity of this study is the responsibility (...) the effectiveness of a mobile application to assist in the prescription of topical corticosteroids (TCS), focusing on best fit choices of potency, vehicle and volume. The mobile application will be developed from the results obtained in a systematic literature review and quality assessment of clinical practice guidelines for topical corticosteroid use. The quality of the guidelines will be assessed using the AGREE II tool. After the app user enters in information concerning patients' rash location and desired

2016 Clinical Trials

87. Differences in therapeutic effects of topically applied corticosteroid and tacrolimus on atopic dermatitis-like symptoms in NC/Nga mice. (PubMed)

Differences in therapeutic effects of topically applied corticosteroid and tacrolimus on atopic dermatitis-like symptoms in NC/Nga mice. Topical corticosteroid and calcineurin inhibitor have similar therapeutic benefits in atopic dermatitis (AD), but the differences in therapeutic mechanisms of action of these agents against AD symptoms are not fully understood.This study was performed to examine the different effects of topical betamethasone valerate (BMV), clobetasol propionate (CBP (...) the strongest effect. CBP significantly reduced epidermal thickness compared with Vas and NT. There were no significant differences in the numbers of interleukin-31-immunoreactive cells and mast cells, or in expression of epidermal thymic stromal lymphopoietin among all five groups.The therapeutic potency of TAC against AD-like symptoms, including pruritus, is equal to that of the corticosteroid CBP. Epidermal innervation of sensory nerves itself might not be related to the therapeutic effects of topical

2016 Journal of dermatological science

88. Topical corticosteroids application in the evening is more effective than in the morning in psoriasis: results of a prospective comparative study. (PubMed)

Topical corticosteroids application in the evening is more effective than in the morning in psoriasis: results of a prospective comparative study. 27790782 2017 04 27 1468-3083 31 5 2017 May Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Topical corticosteroids application in the evening is more effective than in the morning in psoriasis: results of a prospective comparative study. e263-e264 10.1111/jdv.14027 Nguyen S S Department

2016 Journal of the European Academy of Dermatology and Venereology

89. Carers' views of topical-corticosteroid use in childhood eczema: a qualitative study of online discussion forums. (PubMed)

Carers' views of topical-corticosteroid use in childhood eczema: a qualitative study of online discussion forums. Childhood eczema is very common and can have substantial impact on quality of life. One of the main treatments is topical corticosteroids, but these are often underused by parents and carers for reasons that include concerns about safety.To explore understandings and concerns about topical corticosteroids among parents and carers of children with eczema who had posted messages (...) in online forums.A qualitative study of messages and their resultant discussions about topical corticosteroids for childhood eczema posted by parents and carers on two U.K.-based discussion forums.Ninety-five forum users involved in 27 discussions relating to topical corticosteroid use in childhood eczema were identified dating from 2003 to 2015. Analysis of discussions highlighted three themes: (i) diverse beliefs about the use of topical corticosteroids; (ii) uncertainty and confusion about using

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2016 British Journal of Dermatology

90. Descemet's Membrane Endothelial Keratoplasty: Risk of Immunologic Rejection Episodes after Discontinuing Topical Corticosteroids. (PubMed)

Descemet's Membrane Endothelial Keratoplasty: Risk of Immunologic Rejection Episodes after Discontinuing Topical Corticosteroids. To assess the risk of immunologic rejection episodes if topical corticosteroids are discontinued 1 year after Descemet's membrane endothelial keratoplasty (DMEK) compared with continued once-per-day use.Prospective, longitudinal, parallel-group study.A total of 400 eyes of 259 DMEK recipients, aged 23 to 90 years.Patients were enrolled 1 year after DMEK and allowed (...) to choose whether to stop or continue once-daily topical corticosteroids to maximize compliance. Fellow eyes were eligible for enrollment because the donor grafts were independent. Participants were examined at 1, 3, 6, and 12 months during the second year after DMEK. Results were assessed using Kaplan-Meier survival analysis.Incidence of immunologic rejection episodes.Steroids were discontinued in 277 eyes (no steroid group) and continued once per day in 123 eyes (steroid group). The subject

2016 Ophthalmology

91. Medical adherence to topical corticosteroid preparations prescribed for psoriasis: A systematic review. (PubMed)

Medical adherence to topical corticosteroid preparations prescribed for psoriasis: A systematic review. Topical corticosteroids and corticosteroid combinations are the principal treatments in psoriasis. The aim of this study was to investigate published literature dealing with medical adherence to topical corticosteroid or corticosteroid combinations in patients with psoriasis.Systematic electronic searches in English language literature were done until September 2015 without publication date (...) determinants of nonadherence were found. One designed intervention consisted of a disease management program, which improved adherence in the study period. Overall, the studies included were heterogeneous in design and had a high risk of bias.To improve health outcome in topical treatment of psoriasis, further studies should be conducted addressing determinants of nonadherence and test interventions to improve adherence. Validated measurements of medical nonadherence, prescription registers, or medication

2016 The Journal of dermatological treatment

92. Monitoring of topical corticosteroid phobia in a population of parents with children with atopic dermatitis using the TOPICOP<sup>®</sup> scale: prevalence, risk factors and the impact of therapeutic patient education. (PubMed)

Monitoring of topical corticosteroid phobia in a population of parents with children with atopic dermatitis using the TOPICOP® scale: prevalence, risk factors and the impact of therapeutic patient education. 27608366 2017 03 15 1468-3083 31 3 2017 Mar Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Monitoring of topical corticosteroid phobia in a population of parents with children with atopic dermatitis using the TOPICOP ® scale

2016 Journal of the European Academy of Dermatology and Venereology

93. The effects of oral and topical corticosteroid in rabbit corneas. (PubMed)

The effects of oral and topical corticosteroid in rabbit corneas. To determine the most effective route of administration of corticosteroids in the treatment of ocular surface disease, by characterizing the difference between oral prednisolone and topical dexamethasone administration using an animal model.Pharmacokinetic analyses determined the corticosteroid concentrations in the normal ocular tissues of rabbits after oral or topical administration of corticosteroids using LC-MS/MS. In wound (...) observed between orally and topically administered groups. Pharmacokinetic analyses showed that the distribution of dexamethasone after topical administration was superior to that after oral administration in the cornea. In contrast, both concentrations of corticosteroid applied topically and orally were similar with regards to AUCs (area under the concentration-time curve) in the conjunctiva. Although the healing rate was slower in the topical group, all corneas were almost healed within 96 h

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2016 BMC Ophthalmology

94. Does Order of Application of Emollient and Topical Corticosteroids Make a Difference in the Severity of Atopic Eczema in Children? (PubMed)

Does Order of Application of Emollient and Topical Corticosteroids Make a Difference in the Severity of Atopic Eczema in Children? Atopic eczema (AE) is a common chronic inflammatory skin disorder in children, with emollients and topical corticosteroids (TCSs) commonly prescribed as treatment. There is no published guidance on the correct order of application of emollient and TCS in children with AE.The objective of this study was to determine whether the order of application of emollient (...) and that parents can apply topical medications in whichever order they prefer.© 2016 Wiley Periodicals, Inc.

2016 Pediatric dermatology

95. Effects of topical corticosteroid administration on intraocular pressure in normal and glaucomatous cats. (PubMed)

Effects of topical corticosteroid administration on intraocular pressure in normal and glaucomatous cats. The objective of this study was to determine the effect of topical corticosteroid (CCS) therapy on intraocular pressure (IOP) in normal cats and cats with primary feline congenital glaucoma (FCG).Five normal and 11 FCG cats were studied in two cohorts.IOP was measured by a single, masked observer, once daily, 3-5 days/week throughout the course of CCS treatment and for up to 11 days after (...) treatment discontinuation. One eye per cat was randomly assigned for treatment twice daily with CCS; balanced salt solution (BSS) applied to the contralateral eye served as a control. Differences between eyes and between weeks of the study period were calculated for each cat. A positive response to CCS was defined as a consistent >15% or >25% higher IOP in the treated relative to control eye in normal and FCG cats, respectively.A total of 8 of 11 FCG cats responded to topical CCS after 1-5 weeks

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2016 Veterinary ophthalmology

96. Topical Corticosteroid Concerns in Dermatological Outpatients: A Cross-Sectional and Interventional Study. (PubMed)

Topical Corticosteroid Concerns in Dermatological Outpatients: A Cross-Sectional and Interventional Study. Topical corticosteroid concerns (TCC) are an important issue in patients with atopic dermatitis, leading to non-adherence with poor disease control and increased health care costs. However, neither the prevalence of TCC in a more comprehensible dermatological population nor the impact of patient information on topical corticosteroids given by clinicians is known. Therefore, we assessed (...) the prevalence, characteristics, and sources of TCC in a dermatological population and the impact of written and oral patient information on TCC.A total of 643 outpatients with various skin diseases answered a 12-item questionnaire while waiting for the doctor's visit. Patients with TCC quantified their concerns on a discrete visual analogue scale before and after patient information, which consisted of written and oral information about topical corticosteroids (TCS) given by dermatologists.The prevalence

2016 Dermatology

97. Effect of sodium hyluronate added to topical corticosteroids in chronic rhinosinusitis with nasal polyposis. (PubMed)

Effect of sodium hyluronate added to topical corticosteroids in chronic rhinosinusitis with nasal polyposis. Available medical treatments for chronic rhinosinusitis (CRS) with nasal polyposis (CRSwNP) comprise systemic and topical therapies. Although topical corticosteroids are effective in the treatment of CRS, they are not completely devoid of adverse effects. Thus, care has to be taken when long-term treatments are prescribed. There is recent evidence that sodium hyaluronate (SH), the major (...) component of many extracellular matrices, promotes tissue healing, including activation and moderation of the inflammatory responses, cell proliferation, migration, and angiogenesis.The aim of the study was to evaluate clinical outcomes and quality of life in two groups of patients with CRSwNP treated with topical corticosteroids alone or in combination with 9 mg of high-molecular-weight SH.The impact of treatments was determined by using nasal endoscopy and validated quality of life questionnaires

2016 American journal of rhinology & allergy

98. Topical application of a vitamin D3 analogue and corticosteroid to psoriasis plaques decreases skin infiltration of T<sub>H</sub>17 cells and their ex vivo expansion. (PubMed)

Topical application of a vitamin D3 analogue and corticosteroid to psoriasis plaques decreases skin infiltration of TH17 cells and their ex vivo expansion. Topical combination of a vitamin D3 analogue and corticosteroid is widely used for the treatment of psoriasis, a TH17-mediated disorder, but the underlying mechanism remains unclear.We investigated the effect of this topical applicant, focusing on skin-infiltrating TH17 cells.In 10 patients with plaque psoriasis, calcipotriol (Cal (...) improvement was found in the following order: CB > Cal > Bet > control or CB > Bet > Cal > control. Numbers of ex vivo expanded T cells were decreased by topical application of Bet and CB, and CB exhibited the most suppressive result. Numbers and frequencies of TH17 cells were significantly reduced by CB and Cal, suggesting that Cal has a capacity to preferentially suppress TH17 cells. When the stocked T cells from control samples were stimulated with anti-CD3 antibodies in the presence of Bet, Cal

2016 Journal of Allergy and Clinical Immunology

99. Topical versus oral antibiotics, with or without corticosteroids, in the treatment of tympanostomy tube otorrhea. (PubMed)

Topical versus oral antibiotics, with or without corticosteroids, in the treatment of tympanostomy tube otorrhea. Antibiotic treatment is the standard of care for tympanostomy tube otorrhea. This meta-analysis aims to evaluate the efficacy of topical antibiotics with or without corticosteroids versus oral antibiotics in the treatment of tube otorrhea in children.MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and ProQuest.The above databases were searched using a search strategy (...) corticosteroids as an adjunct to topical antibiotics.Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

2016 International Journal of Pediatric Otorhinolaryngology

100. Impact of the Topical Ophthalmic Corticosteroid Loteprednol Etabonate on Intraocular Pressure (PubMed)

Impact of the Topical Ophthalmic Corticosteroid Loteprednol Etabonate on Intraocular Pressure Corticosteroids are a mainstay therapeutic option for the treatment of ocular inflammation. However, safety remains a concern for clinicians, particularly with long-term use. Though highly effective at suppressing inflammatory and allergic responses, topical ophthalmic corticosteroids carry an inherent risk of side effects, including elevated intraocular pressure (IOP), a risk factor (...) for the development of glaucoma. The corticosteroid loteprednol etabonate (LE) contains an ester rather than a ketone at the C-20 position, minimizing the potential for side effects, including IOP elevation. In early pivotal clinical trials of LE ophthalmic suspension for conjunctivitis (allergic, giant papillary), anterior uveitis, and post-operative inflammation, LE had minimal impact on IOP over short-term (<28 days) and long-term (≥28 days) use. Since then, new LE formulations-including a gel, an ointment

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2016 Advances in therapy

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