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Topical Corticosteroid

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28341. Influence of topical steroid treatment on maxillary sinusitis. (Abstract)

Influence of topical steroid treatment on maxillary sinusitis. The clinical efficacy and adverse effects of budesonide administered as a nasal aerosol in addition to sinus washings and erythromycin therapy was assessed by comparison with placebo in a randomized, double-blind study of 40 patients with chronic or recurrent maxillary sinusitis. Most of the patients had been referred for operative treatment. Corticosteroid therapy, 400 micrograms daily, or placebo was continued for 3 months (...) epidermidis and Haemophilus influenzae. Only 2 of 20 Haemophilus strains were beta-lactamase producers. The cellular picture was dominated by neutrophils in all secretions. There was no significant difference in clinical outcome between the two groups. Topical steroid therapy did not cause any adverse effects.

1992 Rhinology Controlled trial quality: uncertain

28342. [Anti-inflammatory effect of topical diclofenac sodium (Voltarène Ophta) after argon laser trabeculoplasty: preliminary results of a prospective double-blind method]. (Abstract)

angle glaucomas (POAG). We also showed that topical diclofenac reduced inflammation in all 17 treated patients. Prostaglandins are thought to play a major role in ALT-inflammation and it is therefore logical to assume that NSAID are effective in that situation and will probably advantageously replace corticosteroids. In order to assess the anti-inflammatory effect of diclofenac drops (Voltaren Ophtha) we included a total of 37 PIG or PEXG (19 in the diclofenac and 18 in the placebo group) scheduled (...) [Anti-inflammatory effect of topical diclofenac sodium (Voltarène Ophta) after argon laser trabeculoplasty: preliminary results of a prospective double-blind method]. Using the laser flare-cell meter (LFMC), we have previously determined the intensity and pattern of post-ALT ocular inflammation. Inflammation peak occurs 48 hours after ALT and clinically relevant inflammation is seen in 100% of pigmentary glaucomas (PIG), 75% of pseudoexfoliative glaucomas (PEXG) but only in 25% of primary open

1992 Klinische Monatsblatter fur Augenheilkunde Controlled trial quality: uncertain

28343. Topical indometacin, a prostaglandin inhibitor, in acute anterior uveitis. A controlled clinical trial of non-steroid versus steroid anti-inflammatory treatment. (Abstract)

Topical indometacin, a prostaglandin inhibitor, in acute anterior uveitis. A controlled clinical trial of non-steroid versus steroid anti-inflammatory treatment. Forty-nine patients were included in a controlled clinical trial comparing the effect of topical non-steroid versus potent steroid preparation in acute anterior non-granulomatous uveitis. Twenty-five patients were randomized to 1% Indometacin and 24 patients to 0.1% Dexametason treatment 6 times a day. There was no difference between (...) the two groups initially. After 7 days of treatment we found significantly less inflammation in the steroid treated group, this significant difference disappearing on day 14. We conclude that whenever adverse reactions to corticosteroid eye drops are suspected or proven, Indometacin eye drops make up a useful alternative to even strong solutions of steroids. The study was carried out in the following practices: L. Ahrendt, L. Damgård-Jensen, P. Eldrup-Jørgensen, J. Elmeros, H. Heuer, S. Jensen, M.H

1991 Acta ophthalmologica Controlled trial quality: uncertain

28344. Dose-response relationship of topically applied methylprednisolone aceponate (MPA) in healthy volunteers. (Abstract)

Dose-response relationship of topically applied methylprednisolone aceponate (MPA) in healthy volunteers. Topical glucocorticosteroids are useful in the treatment of various skin diseases. Although many corticosteroids are available today, there is still a need for highly potent compounds with minimal adverse effects. Methylprednisolone aceponate (MPA) has recently been synthesized. Its activity has been evaluated using the vasoconstrictor assay and the poison ivy test (rhus dermatitis) in 19

1992 European journal of clinical pharmacology Controlled trial quality: uncertain

28345. The same glucocorticoid in brand-name products. Does increasing the concentration result in greater topical biologic activity? (Abstract)

The same glucocorticoid in brand-name products. Does increasing the concentration result in greater topical biologic activity? Many topical corticosteroid formulations are available as different concentrations of the steroid in a similar vehicle. We tested the existing assumption that higher concentrations give greater biologic activity. The vasoconstriction assay was used because of its known correlation with clinical activity. Statistical analyses of the different concentrations

1989 Archives of Dermatology Controlled trial quality: uncertain

28346. The effect of combined topical steroids and habit-reversal treatment in patients with atopic dermatitis. (Abstract)

The effect of combined topical steroids and habit-reversal treatment in patients with atopic dermatitis. A modified behavioural method called habit-reversal, in combination with potent and weak corticosteroid cream, was compared with the use of the creams alone in the treatment of 45 patients with atopic dermatitis. The patients were randomly assigned to four groups, which received two different cream regimes in combination with the habit-reversal treatment. The patients' skin was assessed

1989 The British journal of dermatology Controlled trial quality: uncertain

28347. Reversal effects of topical retinoic acid on the skin of kidney transplant recipients under systemic corticotherapy. (Abstract)

Reversal effects of topical retinoic acid on the skin of kidney transplant recipients under systemic corticotherapy. The systemic long-term corticosteroid treatment administered to kidney graft recipients (KGR) within the framework of the required immunosuppressive therapy induces an atrophy of the skin, from the sixth month onwards. We studied the effect of topical all-trans retinoic acid (0.05%; Galderma Labs.) applied to the forearms of 27 KGR (14 men, 13 women) over a 6-month period. Twenty

1990 The Journal of investigative dermatology Controlled trial quality: uncertain

28348. Topical diclofenac in the treatment of ocular pain after excimer photorefractive keratectomy. (Abstract)

Topical diclofenac in the treatment of ocular pain after excimer photorefractive keratectomy. Following excimer laser photorefractive keratectomy, patients experience significant ocular pain until corneal reepithelialization. Despite the use of cold compresses, bandage soft contact lenses, cycloplegics, narcotics, and topical corticosteroids, the pain has not been adequately controlled in many patients.A randomized, double-masked, parallel-group study of diclofenac sodium 0.1% ophthalmic (...) solution and its placebo vehicle was evaluated. Patients undergoing excimer myopic photorefractive keratectomy on their second eye were admitted overnight. Postoperative procedures included two drops of diclofenac or placebo immediately after surgery and then qid until reepithelialization, topical tobramycin (qid), 0.1% fluorometholone (q2h), cycloplegics, and a disposable soft contact lens. Thirty-two patients (diclofenac = 16, placebo = 16) were evaluated from +30 minutes to +96 hours by several

1994 Refractive & corneal surgery Controlled trial quality: uncertain

28349. The effect of topical fluticasone propionate on intranasal histamine challenge in subjects with perennial allergic rhinitis. (Abstract)

The effect of topical fluticasone propionate on intranasal histamine challenge in subjects with perennial allergic rhinitis. The mechanism of action of topical intranasal steroids is obscure. To investigate this, we have studied the effects of a topical intranasal corticosteroid, fluticasone propionate on nasal airflow resistance (Rnaw), secretions, cytological smears and symptoms. Fluticasone propionate aqueous nasal spray was given to 11 patients with perennial allergic rhinitis in a double

1995 Clinical otolaryngology and allied sciences Controlled trial quality: uncertain

28350. Topical cyclosporin in oral lichen planus: a controlled, randomized, prospective trial. (Abstract)

Topical cyclosporin in oral lichen planus: a controlled, randomized, prospective trial. The published studies of topical cyclosporin (CyA) therapy in chronic oral lichen planus (OLP) have shown conflicting results. We report an investigator-blinded study of 13 patients with OLP, who were randomly assigned to treatment with CyA (500 mg as a swish-and-spit medication for 5 min three times daily) or a corticosteroid oral paste (triamcinolone acetonide). The duration of treatment was 6 weeks (...) . Thereafter, patients on corticosteroid therapy were treated with CyA. Only slight, transient clinical improvement was observed in both groups after 6 weeks of treatment, compared with baseline. No significant differences could be demonstrated between the two groups. CyA therapy following corticosteroid treatment did not produce any further clinical improvement. During follow-up of the disease for up to 1 year after treatment, neither the CyA nor the corticosteroid group exhibited long-term improvement

1995 The British journal of dermatology Controlled trial quality: uncertain

28351. Skin atrophy induced by initial continuous topical application of clobetasol followed by intermittent application. (Abstract)

Skin atrophy induced by initial continuous topical application of clobetasol followed by intermittent application. The most frequent side effect of a long-term topical corticosteroid therapy is skin atrophy. To avoid or to reduce atrophy often an initial continuous application is followed by an intermittent maintenance therapy.In this study we measured the skin thickness before and after the two-phase application schedule with the superpotent topical steroid clobetasol propionate (CP). For 16

1995 Dermatology (Basel, Switzerland) Controlled trial quality: uncertain

28352. Circadian activity of topical 0.05% betamethasone dipropionate in human skin in vivo. (Abstract)

at 1600 h produced more extensive and prolonged changes in skin color over 24 h than a 0900-h application in the same subject. These data demonstrate that the extent and duration of topical corticosteroid activity in human skin is influenced by vehicle, treatment duration, and time of day of application. The prolonged changes in skin color measured with a single dose applied at 1600 h suggest that a once-a-day dosing regimen in the late afternoon may be sufficient for dermatologic therapy. Elucidation (...) of these circadian responses with topical corticosteroids may provide a rational basis for the future re-evaluation of the appropriate therapeutic regimen with this class of drugs in dermatologic medicine.

1994 The Journal of investigative dermatology Controlled trial quality: uncertain

28353. Fluticasone propionate: topical or systemic effects? (Abstract)

Fluticasone propionate: topical or systemic effects? Intranasal corticosteroids have been shown to be more effective than oral antihistamines for the treatment of seasonal allergic rhinitis. However, there are some who question whether intranasally administered corticosteroids should be used due to potential systemic effects. Fluticasone propionate, a potent corticosteroid with high specificity for the glucocorticoid receptor, is available as an aqueous nasal spray for the treatment of allergic (...) rhinitis. To determine whether the efficacy of fluticasone propionate aqueous nasal spray (FPANS) was due to direct topical effects on the nasal mucosa or to indirect systemic effects following absorption from the nasal mucosa or from the swallowed portion of an intranasal dose, FPANS 200 micrograms once daily was compared with oral fluticasone propionate 5 mg or 10 mg once daily or placebo for 2 weeks in patients with seasonal allergic rhinitis. These oral dosages were chosen to yield low

1996 Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Controlled trial quality: uncertain

28354. The kinetics of skin thinning induced by topical fluticasone propionate 0.05% cream in volunteer subjects. (Abstract)

The kinetics of skin thinning induced by topical fluticasone propionate 0.05% cream in volunteer subjects. Fluticasone propionate (FP) 0.05% (CutivateTM) cream is a novel corticosteroid used for the treatment of corticosteroid-responsive dermatoses. To date there are no published data concerning its effect on cutaneous atrophy. This randomized, double-blind study of 40 volunteer subjects was performed to investigate the kinetics of skin thinning induced by topical 0.05% FP cream vs. placebo

1996 Clinical and experimental dermatology Controlled trial quality: uncertain

28355. Efficacy of a topical suspension of bacterial antigens for the management of recurrent eczema in children. (Abstract)

Efficacy of a topical suspension of bacterial antigens for the management of recurrent eczema in children. The aim of this study was to compare the efficacy and safety of a topical suspension of bacterial antigens for the management of recurrent eczema in children.Eighty pediatric patients, aged between 2 and 6 years, with a history of recurrent external auditory eczema, were enrolled in this study. Congenital immune deficiencies, treatment with corticosteroids, immunostimulant (...) or immunosuppressive agents in the past 6 months, and bronchopulmonary disease were considered as exclusion criteria. The patients were randomized to receive topical suspension of bacterial antigens (Lantigen B) (Group A) or placebo (physiological solution) (Group B). The efficacy parameters were evaluated before, at the end of, and one year after the beginning of the therapy. All the children underwent clinical examinations, blood test, skin prick tests (SPT), and clinical evaluation using the clinical score

2004 Medical science monitor : international medical journal of experimental and clinical research Controlled trial quality: uncertain

28356. A Study to Evaluate Raptiva in Combination With Topical Psoriasis Therapies

): Genentech, Inc. Study Details Study Description Go to Brief Summary: This study is an open label, randomized, multicenter study designed to compare the efficacy of 12 weeks of subcutaneously administered efalizumab (monotherapy) with that of combination therapy (Efalizumab and a topical corticosteroid ointment) in subjects with moderate to severe plaque psoriasis who are candidates for systemic therapy. The study will also evaluate the safety and tolerability of 30 months of continuous efalizumab (...) ., etanercept, LFA3TIP) History of severe allergic reactions to or intolerance of topical corticosteroid therapies Previous treatment with efalizumab History of treatment with lymphocyte-depleting monoclonal antibodies or immunoadhesion molecules (e.g., anti-CD4, CTLA4-Ig, LFA3TIP) WBC count <4000/uL or >14,000/uL Hepatic enzymes >=3 times the upper limit of normal Creatinine >=2 times the upper limit of normal Any medical condition that, in the judgment of the investigator, would jeopardize the subject's

2004 Clinical Trials

28357. Double-blind, randomized, placebo-controlled study of topical 5% acyclovir-1% hydrocortisone cream (ME-609) for treatment of UV radiation-induced herpes labialis. Full Text available with Trip Pro

Double-blind, randomized, placebo-controlled study of topical 5% acyclovir-1% hydrocortisone cream (ME-609) for treatment of UV radiation-induced herpes labialis. Immunopathology is recognized as an important component of infectious disease manifestations, and corticosteroids have been used as an adjunct to antimicrobial therapy for a variety of conditions. Antiviral therapy of herpes labialis has been shown to result in only a small reduction in the time to healing and the duration of pain (...) . To determine if topical application of a combination product containing 5% acyclovir and 1% hydrocortisone (ME-609) could provide benefit to herpes labialis patients, 380 immunocompetent adults with a history of herpes labialis were exposed to experimental UV radiation (UVR) to induce a recurrence. On day 2, just before the appearance of the majority of lesions ("delayed" lesions), subjects were randomized to receive active medication or vehicle control six times per day for 5 days. Overall, 120 of 380

2002 Antimicrobial agents and chemotherapy Controlled trial quality: uncertain

28358. The effect of topically applied aspirin on localized circumscribed neurodermatitis. (Abstract)

simplex chronicus.Twenty-nine patients with lichen simplex chronicus of at least 3 months' duration that did not respond to topical corticosteroids were randomized in a double-blind fashion to receive aspirin/dichloromethane solution in treatment period 1 for 2 weeks followed by placebo in treatment period 2 or placebo followed by aspirin in period 2 with a crossover design after a 2-week washout. The patients rated the pruritus intensity before and during therapy with a visual analog scale; a blinded (...) The effect of topically applied aspirin on localized circumscribed neurodermatitis. Lichen simplex chronicus is a troublesome intractable itchy dermatosis, which may persist despite intensive topical treatments. Recently it has been demonstrated that topical aspirin solution with dichloromethane has a significant antipruritic effect in an experimentally induced itch.The aim of this double-blind, crossover placebo trial was to evaluate the efficacy of this solution in the treatment of lichen

2001 Journal of the American Academy of Dermatology Controlled trial quality: uncertain

28359. The treatment of oral aphthous ulceration or erosive lichen planus with topical clobetasol propionate in three preparations: a clinical and pilot study on 54 patients. (Abstract)

The treatment of oral aphthous ulceration or erosive lichen planus with topical clobetasol propionate in three preparations: a clinical and pilot study on 54 patients. This study evaluated the clinical use of a corticosteroid in three preparations (topical clobetasol propionate ointment, clobetasol propionate in an oral analgesic base, and clobetasol propionate in an adhesive denture paste).Fifty-four patients (34 males and 20 females) with a history of vesiculo-ulcero-erosive oral lesions were (...) selected: 24 with oral erosive lichen planus and 30 with aphthae. The subjects enrolled were randomly divided into three groups, each of 18 patients (10 with aphthae and 8 with lichen planus): the first was treated with topical clobetasol propionate ointment (0.05%) directly on the lesion(s) three times a day; the second with clobetasol propionate in an adhesive denture paste in equal amounts (1:1) two times a day; the third with clobetasol propionate in an oral analgesic base (Orabase-B) in equal

2001 Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology Controlled trial quality: uncertain

28360. Topical cosmetics and perioral dermatitis. (Abstract)

Topical cosmetics and perioral dermatitis. Perioral dermatitis (PD) is a common dermatological disease whose aetiology and pathogenesis remain speculative. Both cosmetics and topical corticosteroids have been implicated.75 patients with PD and 125 randomly selected control patients with negative PD records were included in a questionnaire-based study focusing on cosmetics, their use, and topical corticosteroids. The patients were assessed for atopy by clinical criteria, prick tests and specific (...) of product, frequency of care). The mean monthly expenditure on cosmetic products did not differ significantly between the two groups. 25.3% of the patients used topical corticosteroids which were initiated in all cases after the onset of the rash. Significantly (p < 0.001) higher values were found in the patient group regarding history of atopic diseases (49.3% vs. 15.2%), prick test reactivity (> or =2 reactive prick tests: 49.3% vs. 8.0%), and specific IgE against aeroallergens (CAP SX1 classes

2004 Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG Controlled trial quality: uncertain

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