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Topical Corticosteroid

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28101. Topical nitrogen mustard ointment with occlusion for Langerhans' cell histiocytosis of the scalp. (Abstract)

Topical nitrogen mustard ointment with occlusion for Langerhans' cell histiocytosis of the scalp. Topical nitrogen mustard solution has been used as an effective alternative to corticosteroids for the treatment of cutaneous eruptions of Langerhans' cell histiocytosis (LCH). When used as an ointment under occlusion, nitrogen mustard may still be effective and possess less risk of unwanted side effects.A patient with scalp LCH was treated topically with nitrogen mustard ointment 0.01% under

2003 Journal of Dermatological Treatment

28102. An open-label pilot study to evaluate the safety and efficacy of topically applied tacrolimus ointment for the treatment of hand and/or foot eczema. (Abstract)

An open-label pilot study to evaluate the safety and efficacy of topically applied tacrolimus ointment for the treatment of hand and/or foot eczema. Hand and foot eczema is a chronic skin disorder. Although topical corticosteroids are often used to control the predominant symptoms of the disease, the chronicity of the condition increases the risk of long-term adverse effects. A safer alternative is needed.To evaluate the safety and efficacy of tacrolimus ointment 0.1% in hand and/or foot (...) returned to pre-treatment levels.Tacrolimus ointment 0.1% is a promising corticosteroid alternative for hand/foot eczema.

2003 Journal of Dermatological Treatment

28103. Treatment of chronic erosive oral lichen planus with low concentrations of topical tacrolimus: an open prospective study. (Abstract)

as the first month of treatment. No severe adverse effects were observed. All patients had whole-blood concentrations of tacrolimus below the detection limit of the assay (1.5 ng/mL) at all intervals. At 9 months, 6 patients had had a relapse within a mean of 38.6 days. At 12 months, all patients had had a relapse and required treatment with topical corticosteroids or systemic hydroxychloroquine sulfate.Results of our study suggest a rapid and important palliating effect of low concentration of topical (...) Treatment of chronic erosive oral lichen planus with low concentrations of topical tacrolimus: an open prospective study. Chronic erosive oral lichen planus (EOLP) is a severe form of lichen of the buccal mucosa that is often resistant to systemic or topical therapies.To evaluate the efficacy and safety of topical tacrolimus, 0.1 mg per 100 mL of water, in treating EOLP.Open-label, prospective, noncomparative study, with 6 months of treatment and 6 months of follow-up.Dermatology department

2002 Archives of Dermatology

28104. Successful treatment of anogenital lichen sclerosus with topical tacrolimus. Full Text available with Trip Pro

Successful treatment of anogenital lichen sclerosus with topical tacrolimus. Lichen sclerosus of the anogenital area is a chronic inflammatory and fibrosclerotic disease associated with substantial morbidity. Topical ultrapotent corticosteroids are currently the treatment of choice.Three prepubertal girls and 3 adults (2 men, 1 woman) were treated with 0.1% tacrolimus ointment once daily. All patients experienced complete resolution with long-lasting remission for up to 1 year. No major adverse (...) effects were observed, and treatment was well tolerated.Topical tacrolimus is a promising novel agent in the treatment of lichen sclerosus of the anogenital area. A major advantage over topical corticosteroids is the lack of skin atrophy. Further clinical trials are warranted to confirm our findings.

2003 Archives of Dermatology

28105. Efficacy of topical tacrolimus for treating the malar rash of systemic lupus erythematosus. (Abstract)

Efficacy of topical tacrolimus for treating the malar rash of systemic lupus erythematosus. The rash of systemic lupus erythematosus (SLE) is usually treated with topical corticosteroids, but prolonged use causes adverse cutaneous side-effects. We assessed the efficacy of topical tacrolimus for treating the skin lesions of SLE. Three patients with SLE affecting their facial skin applied 0.1% tacrolimus ointment on one side of their face twice daily for 3 weeks, in conjunction with a sunscreen (...) cream. After 3 weeks, erythema on the treated side was ameliorated in all three patients compared with the untreated side. Although the study is preliminary, the results demonstrate that topical tacrolimus may be useful for treating the malar rash of SLE.

2003 British Journal of Dermatology

28106. Treatment of necrobiosis lipoidica with topical psoralen plus ultraviolet A. (Abstract)

Treatment of necrobiosis lipoidica with topical psoralen plus ultraviolet A. Necrobiosis lipoidica (NL) is a rare skin disease, mostly seen on the legs and often occurring in patients with diabetes mellitus. The disease belongs to the idiopathic cutaneous palisading granulomatous dermatitides associated with a degeneration of collagen, thus leading to skin atrophy. Application of topical corticosteroids is the most widely used treatment but the results are not always satisfactory and may worsen (...) skin atrophy. Preliminary studies in patients with NL have shown a clinical response with psoralen plus ultraviolet (UV) A (PUVA). Objectives To study the effect of topical PUVA on NL in a multicentre prospective study.Thirty patients (27 women and three men) including 13 with insulin-dependent diabetes mellitus, with a diagnosis of NL proven by histopathology, were included. All patients had been unsuccessfully treated with topical and/or intralesional corticosteroids. Patients were treated twice

2002 British Journal of Dermatology

28107. Airway-stabilizing effect of long-acting beta2-agonists as add-on therapy to inhaled corticosteroids

University of Dundee. Bibliographic details Currie G P, Jackson C M, Ogston S A, Lipworth B J. Airway-stabilizing effect of long-acting beta2-agonists as add-on therapy to inhaled corticosteroids. QJM: an International Journal of Medicine 2003; 96(6): 435-440 Indexing Status Subject indexing assigned by NLM MeSH Adrenal Cortex Hormones /therapeutic use; Adrenergic beta-Agonists /therapeutic use; Albuterol /analogs & Asthma /prevention & Bronchodilator Agents /therapeutic use; Ethanolamines /therapeutic (...) Airway-stabilizing effect of long-acting beta2-agonists as add-on therapy to inhaled corticosteroids Airway-stabilizing effect of long-acting beta2-agonists as add-on therapy to inhaled corticosteroids Airway-stabilizing effect of long-acting beta2-agonists as add-on therapy to inhaled corticosteroids Currie G P, Jackson C M, Ogston S A, Lipworth B J CRD summary This review assessed the bronchoprotective effects of salmeterol or formeterol in patients with asthma who were using corticosteroid

2003 DARE.

28108. Effects of a single course of corticosteroids given more than 7 days before birth: a systematic review

Effects of a single course of corticosteroids given more than 7 days before birth: a systematic review Effects of a single course of corticosteroids given more than 7 days before birth: a systematic review Effects of a single course of corticosteroids given more than 7 days before birth: a systematic review McLaughlin K J, Crowther C A, Walker N, Harding J E CRD summary This review concluded that exposure to a single course of prenatal corticosteroids administered more than 7 days before birth (...) does not reduce the incidence of respiratory distress syndrome, but can increase the risk of perinatal mortality, earlier birth and maternal infectious morbidity. The review was generally well-conducted and, despite a few methodological considerations, the conclusions are likely to be reliable. Authors' objectives To determine the effects of a single course of prenatal corticosteroids administered more than 7 days before birth on foetal, neonatal and maternal mortality and morbidity. Searching

2003 DARE.

28109. Dose response of inhaled corticosteroids on bronchial hyperresponsiveness: a meta-analysis

Dose response of inhaled corticosteroids on bronchial hyperresponsiveness: a meta-analysis Dose response of inhaled corticosteroids on bronchial hyperresponsiveness: a meta-analysis Dose response of inhaled corticosteroids on bronchial hyperresponsiveness: a meta-analysis Currie G P, Fowler S J, Lipworth B J CRD summary This review assessed the relationship between inhaled corticosteroid dose and bronchial hyperresponsiveness in patients with asthma. The authors concluded that high doses (...) conferred greater improvements than low doses. The conclusions appear to follow from the evidence presented but it is difficult to comment on their reliability because of methodological and reporting limitations in the review. Authors' objectives To determine whether a dose-response effect exists between inhaled corticosteroids and bronchial hyper-responsiveness (BHR) in asthmatic patients. Searching MEDLINE, databases on BIDS, and the Cochrane Library were searched up to May 2001; the search terms were

2003 DARE.

28110. A meta-analysis of the dose-response relationship of inhaled corticosteroids in adolescents and adults with mild to moderate persistent asthma

with mild to moderate persistent asthma. Clinical Therapeutics 2002; 24(1): 1-20 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Administration, Inhalation; Adolescent; Adrenal Cortex Hormones /administration & Adult; Algorithms; Anti-Asthmatic Agents /administration & Asthma /drug therapy /pathology /physiopathology; Dose-Response Relationship, Drug; Humans; Randomized Controlled Trials as Topic; Respiratory Function Tests; Treatment Outcome; dosage /therapeutic use; dosage /therapeutic (...) A meta-analysis of the dose-response relationship of inhaled corticosteroids in adolescents and adults with mild to moderate persistent asthma A meta-analysis of the dose-response relationship of inhaled corticosteroids in adolescents and adults with mild to moderate persistent asthma A meta-analysis of the dose-response relationship of inhaled corticosteroids in adolescents and adults with mild to moderate persistent asthma Bousquet J, Ben-Joseph R, Messonnier M, Alemao E, Gould A L Authors

2002 DARE.

28111. Corticosteroid therapy for patients with acute exacerbations of chronic obstructive pulmonary disease: a systematic review

Status Subject indexing assigned by NLM MeSH Acute Disease; Administration, Oral; Adrenal Cortex Hormones /administration & Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Hydrocortisone /administration & Male; Methylprednisolone /administration & Middle Aged; Prednisolone /administration & Prednisone /administration & Prognosis; Pulmonary Disease, Chronic Obstructive /diagnosis /drug therapy /mortality; Randomized Controlled Trials as Topic; Recurrence; Severity (...) Corticosteroid therapy for patients with acute exacerbations of chronic obstructive pulmonary disease: a systematic review Corticosteroid therapy for patients with acute exacerbations of chronic obstructive pulmonary disease: a systematic review Corticosteroid therapy for patients with acute exacerbations of chronic obstructive pulmonary disease: a systematic review Singh J M, Palda V A, Stanbrook M B, Chapman K R Authors' objectives To determine whether corticosteroids are of demonstrable

2002 DARE.

28112. Long-term effects of inhaled corticosteroids on FEV1 in patients with chronic obstructive pulmonary disease: a meta analysis

Cortex Hormones /administration & Forced Expiratory Volume /drug effects; Humans; Pulmonary Disease, Chronic Obstructive /drug therapy /physiopathology; Randomized Controlled Trials as Topic; Spirometry; dosage AccessionNumber 12003008328 Date bibliographic record published 31/01/2006 Date abstract record published 31/01/2006 Record Status This is a critical abstract of a systematic review that meets the criteria for inclusion on DARE. Each critical abstract contains a brief summary of the review (...) -term effects of inhaled corticosteroids on FEV1 in patients with chronic obstructive pulmonary disease: a meta analysis. Annals of Internal Medicine 2003; 138(12): 969-973 PubMedID Original Paper URL Other publications of related interest This additional published commentary may also be of interest. Inhaled corticosteroids in chronic obstructive pulmonary disease [letters]. Ann Intern Med 2003;139:864-5. Indexing Status Subject indexing assigned by NLM MeSH Administration, Inhalation; Adrenal

2003 DARE.

28113. Corticosteroids for herpes zoster: what do they accomplish?

Indexing Status Subject indexing assigned by NLM MeSH Administration, Oral; Administration, Topical; Adrenal Cortex Hormones /adverse effects /therapeutic use; Clinical Trials as Topic; Drug Administration Schedule; Herpes Zoster /complications /drug therapy; Humans; Injections /methods; Neuralgia /prevention & Pain /drug therapy /etiology; Treatment Outcome; control AccessionNumber 12002004474 Date bibliographic record published 31/07/2004 Date abstract record published 31/07/2004 Record Status (...) of corticosteroids for treatment or prevention were eligible for inclusion. One study in which all patients received corticosteroids was excluded. The included studies used oral, topical and injectable corticosteroids (intralesional, intrathecal and epidural). The included studies used the following regimens for herpes zoster: oral prednisone and prednisolone, starting dose from 35 to 60 mg/day, generally tapering over 3 to 4 weeks; oral triamcinolone, 48 mg/day and tapering; corticotropin, 1 mg thrice weekly

2002 DARE.

28114. The effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a systematic review of randomized placebo-controlled trials

F A. The effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a systematic review of randomized placebo-controlled trials. American Journal of Medicine 2002; 113(1): 59-65 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Administration, Inhalation; Adrenal Cortex Hormones /administration & Adult; Aged; Humans; Middle Aged; Multicenter Studies as Topic; Pulmonary Disease, Chronic Obstructive /drug therapy; Randomized Controlled Trials as Topic; Treatment (...) long-term inhaled corticosteroids improve clinically important outcomes (such as exacerbation or death) for patients with stable chronic obstructive pulmonary disease (COPD). Searching MEDLINE (1966 to 2000), EMBASE (1980 to 2001), CINAHL (1982 to 2000), SIGLE (1980 to 2000) and the Cochrane Controlled Trial Register were searched; the search terms were listed. No language restrictions were applied. In addition, the reference lists of retrieved studies were checked and topic experts were consulted

2002 DARE.

28115. Enteral nutrition and corticosteroids in the treatment of acute Crohn's disease in children

Cortex Hormones /adverse effects /therapeutic use; Child; Child, Preschool; Clinical Trials as Topic; Crohn Disease /therapy; Enteral Nutrition; Female; Humans; Male; Remission Induction; Risk; Treatment Outcome AccessionNumber 12000001381 Date bibliographic record published 31/12/2001 Date abstract record published 31/12/2001 Record Status This is a critical abstract of a systematic review that meets the criteria for inclusion on DARE. Each critical abstract contains a brief summary of the review (...) Heuschkel R B, Menache C C, Megerian J T, Baird A E. Enteral nutrition and corticosteroids in the treatment of acute Crohn's disease in children. Journal of Pediatric Gastroenterology and Nutrition 2000; 31(1): 8-15 PubMedID Original Paper URL Other publications of related interest Griffiths AM. Enteral nutrition: the neglected primary therapy of active Crohn's Disease. J Pediatr Gastroenterol Nutr 2000;31:3-5. Indexing Status Subject indexing assigned by NLM MeSH Acute Disease; Adolescent; Adrenal

2000 DARE.

28116. Eficacia de los glucocorticoides en las reagudizaciones de la enfermedad pulmonar obstructiva cronica: metaanalisis de los estudios publicados [The efficacy of corticosteroids in exacerbations of chronic obstructive pulmonary disease: meta-analysis of pub

Clinica 2000; 114(18): 681-684 PubMedID Other publications of related interest Casan P, Belda J. Glucocorticoides en el tratamiento de la enfermedad pulmonar obstructiva cronica (Glucocorticoids in the treatment of chronic obstructive pulmonary disease). Med Clin 2000;114:694-5. Indexing Status Subject indexing assigned by NLM MeSH Adrenal Cortex Hormones /therapeutic use; Clinical Trials as Topic; Drug Administration Routes; Humans; Lung Diseases, Obstructive /drug therapy; MEDLINE; Time Factors (...) ), the Cochrane Library (Issue 3, 1999) and Indice Medico Espanol were searched; the search terms were detailed. The references of retrieved articles were also checked. Reports were restricted to those in English, Spanish, French or Italian. Studies reported in abstract form only were excluded. Study selection Study designs of evaluations included in the review Placebo-controlled trials were eligible for the review. Specific interventions included in the review Studies of topical or systemic corticosteroids

2000 DARE.

28117. Systemic adverse effects of inhaled corticosteroid therapy: a systematic review and meta-analysis

studies for the skin effects endpoints. The number of studies for the ocular end point is not clear in the discussion. Marked adrenal suppression occurs with high doses of inhaled corticosteroid above 1.5 mg/d (0.75 mg/d for fluticosone propionate) although there is a considerable degree of interindividual susceptability. Meta-analysis showed significantly greater potency for dose-related adrenal suppression with fluticasone compared with beclomethasone dipropionate, budesonide, or triamcinolone (...) significant effects on final audit height. Long-term, high-dose inhaled corticosteroids exposure increases the risk for posterior subcapsular cataracts, and, to a much lesser degree, the risk for ocular hypertension and glaucoma. Skin bruising is most likely to occur with high-dose exposure, which correlates with the degree of adrenal suppression. Authors' conclusions The authors state that all inhaled corticosteroids exhibit dose- related systemic adverse effects, although these are less than

1999 DARE.

28118. The role of vitamin D in corticosteroid-induced osteoporosis: a meta-analytic approach

Rheumatol 2000;18:3-4. Indexing Status Subject indexing assigned by NLM MeSH Adrenal Cortex Hormones /adverse effects; Female; Humans; Male; Meta-Analysis as Topic; Osteoporosis /chemically induced /therapy; Randomized Controlled Trials as Topic; Vitamin D /physiology AccessionNumber 11999001644 Date bibliographic record published 31/10/2000 Date abstract record published 31/10/2000 Record Status This is a critical abstract of a systematic review that meets the criteria for inclusion on DARE. Each (...) . disodium monofluorophosphate, sodium fluoride) or hormone replacement therapy, with or without vitamin D or calcium. In all cases vitamin D included any of its metabolites or analogs, e.g. calcitriol, alfacalcidol, dihydrotachsterol. The dose regimens of vitamin D varied in terms of the frequency and size of doses. Doses regimens of the other intervention and control treatments were not stated. Participants included in the review Patients receiving oral corticosteroid therapy, including adults

1999 DARE.

28119. Oral corticosteroid use is effective for cutaneous hemangiomas: an evidence-based evaluation

regimens. Bibliographic details Bennett M L, Fleischer A B, Chamlin S L, Frieden I J. Oral corticosteroid use is effective for cutaneous hemangiomas: an evidence-based evaluation. Archives of Dermatology 2001; 137(9): 1208-1213 PubMedID Original Paper URL Indexing Status Subject indexing assigned by NLM MeSH Adrenal Cortex Hormones /adverse effects /therapeutic use; Evidence-Based Medicine; Hemangioma /drug therapy; Humans; Treatment Outcome AccessionNumber 12001002209 Date bibliographic record (...) searched for original articles on the combined topics of 'hemangiomas and corticosteroids'. In addition, the bibliographies of the identified studies were reviewed. Studies reported in any language were considered, and relevant foreign language articles were translated into English. Unpublished material was excluded. Study selection Study designs of evaluations included in the review Case series with at least five patients were eligible for inclusion, provided that there was sufficient information

2001 DARE.

28120. Limited bone loss due to corticosteroids: a systematic review of prospective studies in rheumatoid arthritis and other diseases

Limited bone loss due to corticosteroids: a systematic review of prospective studies in rheumatoid arthritis and other diseases Limited bone loss due to corticosteroids: a systematic review of prospective studies in rheumatoid arthritis and other diseases Limited bone loss due to corticosteroids: a systematic review of prospective studies in rheumatoid arthritis and other diseases Verhoeven A C, Boers M Authors' objectives To clarify the relationship between changes in bone density, the treated (...) disease and dose of corticosteroids prescribed. Searching The authors provide an outline of 3 clusters of structured keyword searches which they used to locate relevant studies. MEDLINE (from January 1966 to December 1995) was the only database searched. The authors state that no language restrictions applied. A bibliographic search of '6 key reviews' and an additional search of citations in selected studies were also carried out. In addition, the authors inquired amongst colleagues to elicit further

1997 DARE.

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