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Topical Corticosteroid

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181. Carers' views of topical-corticosteroid use in childhood eczema: a qualitative study of online discussion forums. Full Text available with Trip Pro

Carers' views of topical-corticosteroid use in childhood eczema: a qualitative study of online discussion forums. Childhood eczema is very common and can have substantial impact on quality of life. One of the main treatments is topical corticosteroids, but these are often underused by parents and carers for reasons that include concerns about safety.To explore understandings and concerns about topical corticosteroids among parents and carers of children with eczema who had posted messages (...) in online forums.A qualitative study of messages and their resultant discussions about topical corticosteroids for childhood eczema posted by parents and carers on two U.K.-based discussion forums.Ninety-five forum users involved in 27 discussions relating to topical corticosteroid use in childhood eczema were identified dating from 2003 to 2015. Analysis of discussions highlighted three themes: (i) diverse beliefs about the use of topical corticosteroids; (ii) uncertainty and confusion about using

2016 British Journal of Dermatology

182. Topical corticosteroid concerns from the clinicians' perspective. Full Text available with Trip Pro

Topical corticosteroid concerns from the clinicians' perspective. Topical corticosteroids concerns (TCC) are common in dermatology patients, possibly leading to non-adherence to topical corticosteroids (TCS) and poor disease control. Clinicians play a key role in that context, as they can reduce or reinforce these concerns. It is unknown, if clinicians have accurate knowledge of TCC to appropriately address this issue and whether they have concerns themselves to use TCS. This questionnaire

2016 Journal of Dermatological Treatment

183. Effect of sodium hyluronate added to topical corticosteroids in chronic rhinosinusitis with nasal polyposis. Full Text available with Trip Pro

Effect of sodium hyluronate added to topical corticosteroids in chronic rhinosinusitis with nasal polyposis. Available medical treatments for chronic rhinosinusitis (CRS) with nasal polyposis (CRSwNP) comprise systemic and topical therapies. Although topical corticosteroids are effective in the treatment of CRS, they are not completely devoid of adverse effects. Thus, care has to be taken when long-term treatments are prescribed. There is recent evidence that sodium hyaluronate (SH), the major (...) component of many extracellular matrices, promotes tissue healing, including activation and moderation of the inflammatory responses, cell proliferation, migration, and angiogenesis.The aim of the study was to evaluate clinical outcomes and quality of life in two groups of patients with CRSwNP treated with topical corticosteroids alone or in combination with 9 mg of high-molecular-weight SH.The impact of treatments was determined by using nasal endoscopy and validated quality of life questionnaires

2016 American journal of rhinology & allergy

184. Topical application of a vitamin D3 analogue and corticosteroid to psoriasis plaques decreases skin infiltration of T<sub>H</sub>17 cells and their ex vivo expansion. Full Text available with Trip Pro

Topical application of a vitamin D3 analogue and corticosteroid to psoriasis plaques decreases skin infiltration of TH17 cells and their ex vivo expansion. Topical combination of a vitamin D3 analogue and corticosteroid is widely used for the treatment of psoriasis, a TH17-mediated disorder, but the underlying mechanism remains unclear.We investigated the effect of this topical applicant, focusing on skin-infiltrating TH17 cells.In 10 patients with plaque psoriasis, calcipotriol (Cal (...) improvement was found in the following order: CB > Cal > Bet > control or CB > Bet > Cal > control. Numbers of ex vivo expanded T cells were decreased by topical application of Bet and CB, and CB exhibited the most suppressive result. Numbers and frequencies of TH17 cells were significantly reduced by CB and Cal, suggesting that Cal has a capacity to preferentially suppress TH17 cells. When the stocked T cells from control samples were stimulated with anti-CD3 antibodies in the presence of Bet, Cal

2016 Journal of Allergy and Clinical Immunology

185. Topical versus oral antibiotics, with or without corticosteroids, in the treatment of tympanostomy tube otorrhea. (Abstract)

Topical versus oral antibiotics, with or without corticosteroids, in the treatment of tympanostomy tube otorrhea. Antibiotic treatment is the standard of care for tympanostomy tube otorrhea. This meta-analysis aims to evaluate the efficacy of topical antibiotics with or without corticosteroids versus oral antibiotics in the treatment of tube otorrhea in children.MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and ProQuest.The above databases were searched using a search strategy (...) corticosteroids as an adjunct to topical antibiotics.Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

2016 International Journal of Pediatric Otorhinolaryngology

186. Descemet's Membrane Endothelial Keratoplasty: Risk of Immunologic Rejection Episodes after Discontinuing Topical Corticosteroids. (Abstract)

Descemet's Membrane Endothelial Keratoplasty: Risk of Immunologic Rejection Episodes after Discontinuing Topical Corticosteroids. To assess the risk of immunologic rejection episodes if topical corticosteroids are discontinued 1 year after Descemet's membrane endothelial keratoplasty (DMEK) compared with continued once-per-day use.Prospective, longitudinal, parallel-group study.A total of 400 eyes of 259 DMEK recipients, aged 23 to 90 years.Patients were enrolled 1 year after DMEK and allowed (...) to choose whether to stop or continue once-daily topical corticosteroids to maximize compliance. Fellow eyes were eligible for enrollment because the donor grafts were independent. Participants were examined at 1, 3, 6, and 12 months during the second year after DMEK. Results were assessed using Kaplan-Meier survival analysis.Incidence of immunologic rejection episodes.Steroids were discontinued in 277 eyes (no steroid group) and continued once per day in 123 eyes (steroid group). The subject

2016 Ophthalmology

187. Medical adherence to topical corticosteroid preparations prescribed for psoriasis: A systematic review. Full Text available with Trip Pro

Medical adherence to topical corticosteroid preparations prescribed for psoriasis: A systematic review. Topical corticosteroids and corticosteroid combinations are the principal treatments in psoriasis. The aim of this study was to investigate published literature dealing with medical adherence to topical corticosteroid or corticosteroid combinations in patients with psoriasis.Systematic electronic searches in English language literature were done until September 2015 without publication date (...) determinants of nonadherence were found. One designed intervention consisted of a disease management program, which improved adherence in the study period. Overall, the studies included were heterogeneous in design and had a high risk of bias.To improve health outcome in topical treatment of psoriasis, further studies should be conducted addressing determinants of nonadherence and test interventions to improve adherence. Validated measurements of medical nonadherence, prescription registers, or medication

2016 The Journal of dermatological treatment

188. Clinical scores of sleep loss/itch and antihistamine/topical corticosteroid usage for childhood eczema. (Abstract)

Hospital, Shatin, Hong Kong, Hong Kong. Li A M AM Department of Pediatrics, The Chinese University of Hong Kong, 6/F, Clinical Science Building, Prince of Wales Hospital, Shatin, Hong Kong, Hong Kong. Leung T F TF Department of Pediatrics, The Chinese University of Hong Kong, 6/F, Clinical Science Building, Prince of Wales Hospital, Shatin, Hong Kong, Hong Kong. eng Letter 2016 08 10 England Br J Dermatol 0004041 0007-0963 0 Adrenal Cortex Hormones 0 Histamine Antagonists IM Administration, Cutaneous (...) Adolescent Adrenal Cortex Hormones administration & dosage Child Child, Preschool Dermatitis, Atopic complications drug therapy Female Histamine Antagonists administration & dosage Humans Male Pruritus drug therapy etiology Quality of Life Severity of Illness Index Sleep Wake Disorders etiology 2016 10 30 6 0 2017 9 12 6 0 2016 4 11 6 0 ppublish 27061407 10.1111/bjd.14660

2016 British Journal of Dermatology

189. Safety of Topical Corticosteroids in Pregnancy. Full Text available with Trip Pro

Safety of Topical Corticosteroids in Pregnancy. Are topical corticosteroids safe for use in pregnancy?The available evidence found no associations of maternal use of topical corticosteroids of any potency with mode of delivery, birth defects, preterm delivery, fetal death, and low Apgar score. However, maternal use of potent to very potent topical corticosteroids, especially when the cumulative dosage of topical corticosteroids throughout the pregnancy is very large, is associated with low

2016 JAMA dermatology (Chicago, Ill.)

190. Assessment of "corticophobia" as an indicator of non-adherence to topical corticosteroids: A pilot study. (Abstract)

Assessment of "corticophobia" as an indicator of non-adherence to topical corticosteroids: A pilot study. Concerns regarding topical corticosteroid (TCS) use, broadly known as "corticophobia", are highly prevalent among dermatology patients and often result in non-adherence to TCS. This non-adherence contributes to poor disease control and increased health care costs. However, it is unknown if assessment of these concerns might help to identify patients at risk of TCS-non-adherence. Clinical (...) tools indicating non-adherence could be helpful to improve management of this patient group.To assess whether the available tools for measuring concerns regarding corticosteroids, the TOPICOP scale and the 0-10 Visual Analogue Scale (VAS), could help to detect non-adherence to TCS.In 75 patients with concerns regarding TCS use both the TOPICOP scale and VAS were anonymously assessed. A comparison was made between TCS-adherent and non-adherent patients regarding the intensity and characteristics

2016 Journal of Dermatological Treatment

191. Evaluation of the influence of pharmacists and GPs on patient perceptions of long-term topical corticosteroid use. (Abstract)

Evaluation of the influence of pharmacists and GPs on patient perceptions of long-term topical corticosteroid use. To assess pharmacist and general practitioner (GP) advice and behaviors, as related to and reported by patients and parents of patients using topical corticosteroids (TCS) on a long-term basis.Multicenter cross-sectional survey of patients (aged 18+) and parents of pediatric patients (aged <18) with a history of long-term (≥1 month) TCS use, assessing: TCS treatment adherence

2016 Journal of Dermatological Treatment

192. Does Order of Application of Emollient and Topical Corticosteroids Make a Difference in the Severity of Atopic Eczema in Children? (Abstract)

Does Order of Application of Emollient and Topical Corticosteroids Make a Difference in the Severity of Atopic Eczema in Children? Atopic eczema (AE) is a common chronic inflammatory skin disorder in children, with emollients and topical corticosteroids (TCSs) commonly prescribed as treatment. There is no published guidance on the correct order of application of emollient and TCS in children with AE.The objective of this study was to determine whether the order of application of emollient (...) and that parents can apply topical medications in whichever order they prefer.© 2016 Wiley Periodicals, Inc.

2016 Pediatric dermatology

193. Effects of topical corticosteroid administration on intraocular pressure in normal and glaucomatous cats. Full Text available with Trip Pro

Effects of topical corticosteroid administration on intraocular pressure in normal and glaucomatous cats. The objective of this study was to determine the effect of topical corticosteroid (CCS) therapy on intraocular pressure (IOP) in normal cats and cats with primary feline congenital glaucoma (FCG).Five normal and 11 FCG cats were studied in two cohorts.IOP was measured by a single, masked observer, once daily, 3-5 days/week throughout the course of CCS treatment and for up to 11 days after (...) treatment discontinuation. One eye per cat was randomly assigned for treatment twice daily with CCS; balanced salt solution (BSS) applied to the contralateral eye served as a control. Differences between eyes and between weeks of the study period were calculated for each cat. A positive response to CCS was defined as a consistent >15% or >25% higher IOP in the treated relative to control eye in normal and FCG cats, respectively.A total of 8 of 11 FCG cats responded to topical CCS after 1-5 weeks

2016 Veterinary ophthalmology Controlled trial quality: uncertain

194. Topical corticosteroid has no influence on inflammation or efficacy after ingenol mebutate treatment of grade I to III actinic keratoses (AK): A randomized clinical trial. (Abstract)

Topical corticosteroid has no influence on inflammation or efficacy after ingenol mebutate treatment of grade I to III actinic keratoses (AK): A randomized clinical trial. Ingenol mebutate (IngMeb) is approved for treatment of actinic keratoses (AK) and may cause unpredictable local skin responses (LSR).We sought to investigate whether IngMeb-induced LSR, pain, and pruritus could be alleviated with a topical glucocorticoid and, further, to assess efficacy, cosmetic outcome, and patient (...) satisfaction in patients with severe photodamage.In this blinded, randomized controlled clinical trial, patients with multiple AK and field cancerization of the face or scalp were treated in 2 areas with IngMeb (0.015%) daily for 3 days. After finalized IngMeb treatment, 1 area was randomized to receive topical clobetasol propionate (0.05%) twice daily for 4 days. Assessments included LSR (0-24; days 1, 4, 8, 15, 57), pain (0-10) and pruritus (0-3; days 1-15), AK clearance (days 15, 57), and cosmetic

2016 Journal of the American Academy of Dermatology Controlled trial quality: uncertain

195. Proliferative and necrotizing otitis externa in a kitten: successful treatment with intralesional and topical corticosteroid therapy Full Text available with Trip Pro

Proliferative and necrotizing otitis externa in a kitten: successful treatment with intralesional and topical corticosteroid therapy Proliferative and necrotising otitis externa (PNOE) is a very rare disease affecting the ear canals and concave pinnae of kittens. This report describes a 5-month-old cat with PNOE. Histopathological examination confirmed the diagnosis. Treatment was initiated with local injection of methylprednisolone acetate into the lesions. The cat was subsequently treated (...) with clobetasol propionate cream, a potent topical glucocorticoid ointment. The cat showed marked improvement. While topical treatment with tacrolimus, an immunosuppressive agent, is reported to be an effective therapy, to the best of our knowledge, this is the first report to treat PNOE with local corticosteroid therapy.

2016 The Journal of Veterinary Medical Science

196. Spongiotic Trachyonychia Treated with Topical Corticosteroids Using the Paper Tape Occlusion Method Full Text available with Trip Pro

Spongiotic Trachyonychia Treated with Topical Corticosteroids Using the Paper Tape Occlusion Method 27843923 2018 11 13 2296-9195 2 1-2 2016 Sep Skin appendage disorders Skin Appendage Disord Spongiotic Trachyonychia Treated with Topical Corticosteroids Using the Paper Tape Occlusion Method. 49-51 Sakiyama Tomo T Department of Dermatology, Keio University School of Medicine, Tokyo, Japan. Chaya Ayaka A Department of Dermatology, Keio University School of Medicine, Tokyo, Japan. Shimizu Tomoko T (...) Department of Dermatology, Keio University School of Medicine, Tokyo, Japan. Ebihara Tamotsu T Department of Dermatology, Keio University School of Medicine, Tokyo, Japan. Saito Masataka M Department of Dermatology, Keio University School of Medicine, Tokyo, Japan. eng Editorial 2016 05 21 Switzerland Skin Appendage Disord 101670617 2296-9160 Nail matrix Paper tape occlusion method Spongiosis Topical corticosteroids Trachyonychia 2016 02 08 2016 04 22 2016 11 16 6 0 2016 11 16 6 0 2016 11 16 6 1 ppublish

2016 Skin appendage disorders

197. A prospective study of atopic dermatitis managed without topical corticosteroids for a 6-month period Full Text available with Trip Pro

A prospective study of atopic dermatitis managed without topical corticosteroids for a 6-month period Topical corticosteroids (TCS) are regarded as the mainstay treatment for atopic dermatitis (AD). As AD has a tendency to heal naturally, the long-term efficacy of TCS in AD management should be compared with the outcomes seen in patients with AD not using TCS. However, there are few long-term studies that consider patients with AD not using TCS. We designed a prospective multicenter cohort

2016 Clinical, cosmetic and investigational dermatology

198. Topical Corticosteroid Misuse: The Scenario in Patients Attending a Tertiary Care Hospital in New Delhi Full Text available with Trip Pro

Topical Corticosteroid Misuse: The Scenario in Patients Attending a Tertiary Care Hospital in New Delhi Irrational use of Topical Corticosteroid (TC) is quite common in India due to unrestricted availability and use of TC not only by general public but also by physicians and chemists due to quick relief of symptoms in different dermatological conditions.The present study was conducted to evaluate and analyse the prevalence of misuse of TC and the causes behind misuse of TC among patients

2016 Journal of clinical and diagnostic research : JCDR

199. Impact of the Topical Ophthalmic Corticosteroid Loteprednol Etabonate on Intraocular Pressure Full Text available with Trip Pro

Impact of the Topical Ophthalmic Corticosteroid Loteprednol Etabonate on Intraocular Pressure Corticosteroids are a mainstay therapeutic option for the treatment of ocular inflammation. However, safety remains a concern for clinicians, particularly with long-term use. Though highly effective at suppressing inflammatory and allergic responses, topical ophthalmic corticosteroids carry an inherent risk of side effects, including elevated intraocular pressure (IOP), a risk factor (...) for the development of glaucoma. The corticosteroid loteprednol etabonate (LE) contains an ester rather than a ketone at the C-20 position, minimizing the potential for side effects, including IOP elevation. In early pivotal clinical trials of LE ophthalmic suspension for conjunctivitis (allergic, giant papillary), anterior uveitis, and post-operative inflammation, LE had minimal impact on IOP over short-term (<28 days) and long-term (≥28 days) use. Since then, new LE formulations-including a gel, an ointment

2016 Advances in therapy

200. Topical Corticosteroid App

Topical Corticosteroid App Topical Corticosteroid App - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Topical Corticosteroid App The safety and scientific validity of this study is the responsibility (...) the effectiveness of a mobile application to assist in the prescription of topical corticosteroids (TCS), focusing on best fit choices of potency, vehicle and volume. The mobile application will be developed from the results obtained in a systematic literature review and quality assessment of clinical practice guidelines for topical corticosteroid use. The quality of the guidelines will be assessed using the AGREE II tool. After the app user enters in information concerning patients' rash location and desired

2016 Clinical Trials

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