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Topical Corticosteroid

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181. Comparing the effects of cryotherapy with nitrous oxide gas versus topical corticosteroids in the treatment of oral lichen planus. (PubMed)

Comparing the effects of cryotherapy with nitrous oxide gas versus topical corticosteroids in the treatment of oral lichen planus. Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa with treatment challenges for clinicians.The objective of this study is to compare the effects of cryotherapy as a new modality with topical corticosteroids as a conventional therapy in the treatment of OLP.Thirty patients with bilateral OLP lesions were selected. From each patient (...) reduced in all follow-up sessions (P<0.05). But the treatment outcome and relapse was not significantly different between the two treatment methods (P>0.05).Cryotherapy with nitrous oxide gas is as effective as topical triamcinolone acetonide in the treatment of OLP with no systemic side effects and needs less patient compliance. It can be considered as an alternative or adjuvant therapy in OLP patients to reduce the use of treatments with adverse effects.

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2015 Indian journal of dental research : official publication of Indian Society for Dental Research Controlled trial quality: uncertain

182. A systematic review of topical corticosteroid withdrawal ("steroid addiction") in patients with atopic dermatitis and other dermatoses. (PubMed)

A systematic review of topical corticosteroid withdrawal ("steroid addiction") in patients with atopic dermatitis and other dermatoses. The National Eczema Association has received increasing numbers of patient inquiries regarding "steroid addiction syndrome," coinciding with the growing presence of social media dedicated to this topic. Although many of the side effects of topical corticosteroids (TCS) are addressed in guidelines, TCS addiction is not.We sought to assess the current evidence

2015 Journal of American Academy of Dermatology

183. Cushing's Syndrome in a 6-month-old Boy: A Rare Side-effect due to Inadequate use of Topical Corticosteroids. (PubMed)

Cushing's Syndrome in a 6-month-old Boy: A Rare Side-effect due to Inadequate use of Topical Corticosteroids. 26038976 2016 10 17 2016 12 30 1651-2057 96 1 2016 Jan Acta dermato-venereologica Acta Derm. Venereol. Cushing's Syndrome in a 6-month-old Boy: A Rare Side-effect due to Inadequate use of Topical Corticosteroids. 138-9 10.2340/00015555-2151 Ciccone Sara S Unit of Pediatric Endocrinology and Diabetes, S. Anna Hospital of Ferrara, IT-44124 Ferrara, Italy. sara.ciccone@unife.it. Marini

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2015 Acta Dermato-Venereologica

184. Impact of saline irrigation and topical corticosteroids on the postsurgical sinonasal microbiota. (PubMed)

Impact of saline irrigation and topical corticosteroids on the postsurgical sinonasal microbiota. Topical treatments with nasal saline irrigation, topical steroid sprays, or corticosteroid rinses can improve sinonasal symptoms in chronic rhinosinusitis (CRS). However, the impact of these therapies on commensals (Corynebacterium) and on biofilm pathogens associated with CRS (Staphylococcus aureus and Pseudomonas) is not well characterized.Paired nasal and sinus swabs were collected (...) endoscopically from 28 controls and 14 CRS patients with nasal polyposis (CRSwNP) who had not received systemic antibiotics or corticosteroids in the previous 8 weeks. Total DNA from swab eluents were extracted and analyzed by 16S rRNA gene-based pyrosequencing. A total of 359,077 reads were obtained and classified taxonomically. The association of use of topical therapies with sinonasal microbiota composition was assessed by factor/vector-fitting. The proportional abundances of sinonasal bacteria between

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2015 International forum of allergy & rhinology

185. Vulvovaginal photodynamic therapy versus topical corticosteroids in genital erosive lichen planus: a randomized controlled trial. (PubMed)

Vulvovaginal photodynamic therapy versus topical corticosteroids in genital erosive lichen planus: a randomized controlled trial. Genital erosive lichen planus (GELP) in women is a chronic inflammatory disease characterized by painful vulval and vaginal erosions. Topical photodynamic therapy (PDT) is increasingly used in premalignant and malignant diseases and may have an effect in inflammatory diseases.To assess the feasibility, efficacy and safety of hexyl 5-aminolevulinate-hydrocloride (...) (HAL)-PDT in GELP.Forty women, diagnosed with GELP at a specialized vulva clinic, were randomized to one session HAL-PDT in vulva and/or vagina (n = 20) or daily applications of clobetasol propionate 0·05% ointment in vulva and optional hydrocortisone acetate 1·0% foam in vagina for 6 weeks (n = 20). After 6 weeks, all patients were allowed to use topical corticosteroids as needed. Clinical examinations were performed at weeks 0, 6 and 24, using a clinical score developed for the study. All

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2015 The British journal of dermatology Controlled trial quality: uncertain

186. Patient-reported outcomes after discontinuation of long-term topical corticosteroid treatment for atopic dermatitis: a targeted cross-sectional survey (PubMed)

Patient-reported outcomes after discontinuation of long-term topical corticosteroid treatment for atopic dermatitis: a targeted cross-sectional survey Topical corticosteroid (TCS) treatment is widely prescribed for atopic dermatitis (AD). However, TCS treatment is associated with tachyphylaxis, and discontinuation after long-term use may cause exacerbation of symptoms. Some AD patients are reluctant to use TCS.To evaluate patient-reported short- and long-term outcomes after discontinuation

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2015 Drug, healthcare and patient safety

187. Pharmacists' knowledge about use of topical corticosteroids in atopic dermatitis: Pre and post continuing professional development education. (PubMed)

Pharmacists' knowledge about use of topical corticosteroids in atopic dermatitis: Pre and post continuing professional development education. Topical corticosteroids (TCS) are the standard of care in paediatric atopic dermatitis (pAD). Parents commonly cite TCS phobia as a major impediment to treatment adherence. Misinformation on TCS side-effects can impact on perceptions of TCS safety. We aimed to assess pharmacists' beliefs and information on the safety of TCS in pAD treatment and determine

2015 Australasian Journal of Dermatology

188. Topical combination therapy with vitamin D3 and corticosteroid ointment for palmoplantar pustulosis: A prospective, randomized, left-right comparison study. (PubMed)

Topical combination therapy with vitamin D3 and corticosteroid ointment for palmoplantar pustulosis: A prospective, randomized, left-right comparison study. Vitamin D3 ointment and corticosteroid ointment are both used for the treatment of palmoplantar pustulosis (PPP). However, to date there is no systematic study of the efficacy of combination therapy for the treatment of PPP.We compared the efficacy of a topical combination therapy with vitamin D3 and a topical corticosteroid (...) with that of topical corticosteroid alone in the treatment of PPP.We evaluated left-right comparison study of the efficacy of a combination therapy consisting of maxacalcitol ointment and betamethasone butyrate propionate ointment (BBP), and monotherapy with BBP alone in 27 patients with PPP for 8 weeks.The improvement in the symptom (erythema, pustules/vesicles, hyperkeratosis/scales) scores was high for the combination therapy. In particular, the improvement rate for pustules/vesicles at week 8 after

2015 The Journal of dermatological treatment Controlled trial quality: uncertain

189. Long-Term Outcome of Treatment with Topical Corticosteroids for Severe Dry Eye Associated with Sjögren's Syndrome (PubMed)

Long-Term Outcome of Treatment with Topical Corticosteroids for Severe Dry Eye Associated with Sjögren's Syndrome This retrospective study was performed to analyze the long-term outcome of topical corticosteroid treatment for severe dry eye associated with Sjögren's syndrome (SS). Patients who had severe dry eye associated with SS were topically treated with loteprednol etabonate 0.5% (group A, n=66) or fluorometholone 0.1% (group B, n=67) twice daily and were followed up for 2 years. Visual (...) . No significant differences between the groups were found in any parameter during follow-up. At 24 months, the number of patients with IOP elevation of more than 2 mmHg compared with baseline was 4 in group A (6.1%) and 9 in group B (13.4%). The mean IOP in these patients was lower in group A than in group B (15.00±0.82 mmHg versus 16.50±1.12 mmHg; p=0.04). Long-term application of low-dose topical corticosteroids is effective for controlling signs and symptoms of chronic, severe dry eye associated with SS

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2015 Chonnam medical journal

190. Evaluation of Fluid Retention Due to Superpotent Topical Corticosteroid

Evaluation of Fluid Retention Due to Superpotent Topical Corticosteroid Evaluation of Fluid Retention Due to Superpotent Topical Corticosteroid - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Evaluation (...) of Fluid Retention Due to Superpotent Topical Corticosteroid (RECOPB) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02360202 Recruitment Status : Recruiting First Posted : February 10, 2015 Last Update Posted : August 30

2015 Clinical Trials

191. Effect of Topical Corticosteroids on Dysphagia in Anterior Cervical Discectomy and Fusion

Effect of Topical Corticosteroids on Dysphagia in Anterior Cervical Discectomy and Fusion Effect of Topical Corticosteroids on Dysphagia in Anterior Cervical Discectomy and Fusion - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Effect of Topical Corticosteroids on Dysphagia in Anterior Cervical Discectomy and Fusion The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02539394 Recruitment Status : Active, not recruiting First Posted : September 3, 2015 Last Update Posted : February 1, 2019 Sponsor

2015 Clinical Trials

192. Cutaneous Rosai-Dorfman Disease Located on the Breast: Rapid Effectiveness of Methotrexate After Failure of Topical Corticosteroids, Acitretin and Thalidomide. (PubMed)

Cutaneous Rosai-Dorfman Disease Located on the Breast: Rapid Effectiveness of Methotrexate After Failure of Topical Corticosteroids, Acitretin and Thalidomide. 25632986 2016 03 23 2015 06 24 1651-2057 95 6 2015 Jul Acta dermato-venereologica Acta Derm. Venereol. Cutaneous Rosai-Dorfman Disease Located on the Breast: Rapid Effectiveness of Methotrexate After Failure of Topical Corticosteroids, Acitretin and Thalidomide. 758-9 10.2340/00015555-2057 Nadal Marion M Department of Dermatology, CHRU

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2015 Acta Dermato-Venereologica

193. Ocular side-effects of topical corticosteroids: what a dermatologist needs to know. (PubMed)

Ocular side-effects of topical corticosteroids: what a dermatologist needs to know. Topical corticosteroids are used frequently in dermatology and atopic dermatitis without significant adverse effects. Though ocular diseases such as glaucoma and cataracts are known complications of systemic corticosteroids, the role of topical corticosteroids is limited to case reports. This review assesses the literature regarding topical steroids and their role in ocular diseases. There is evidence of harm (...) to vision when potent topical corticosteroids are inappropriately used for prolonged periods to periorbital sites. There is no evidence to date that weak TCS to the face or potent TCS to areas other than the eyes results in ocular complications. Further research trials are required in this area. © 2015 The Australasian College of Dermatologists.

2015 Australasian Journal of Dermatology

194. Adverse effects of topical corticosteroids in paediatric eczema: Australasian consensus statement. (PubMed)

Adverse effects of topical corticosteroids in paediatric eczema: Australasian consensus statement. Atopic eczema is a chronic inflammatory disease affecting about 30% of Australian and New Zealand children. Severe eczema costs over AUD 6000/year per child in direct medical, hospital and treatment costs as well as time off work for caregivers and untold distress for the family unit. In addition, it has a negative impact on a child's sleep, education, development and self-esteem. The treatment (...) of atopic eczema is complex and multifaceted but a core component of therapy is to manage the inflammation with topical corticosteroids (TCS). Despite this, TCS are often underutilised by many parents due to corticosteroid phobia and unfounded concerns about their adverse effects. This has led to extended and unnecessary exacerbations of eczema for children. Contrary to popular perceptions, (TCS) use in paediatric eczema does not cause atrophy, hypopigmentation, hypertrichosis, osteoporosis, purpura

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2015 Australasian Journal of Dermatology

195. Silver Nitrate Application and Topical Corticosteroids for Hypergranulation Tissue

Silver Nitrate Application and Topical Corticosteroids for Hypergranulation Tissue Silver Nitrate Application and Topical Corticosteroids for Hypergranulation Tissue - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Silver Nitrate Application and Topical Corticosteroids for Hypergranulation Tissue The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02398539 Recruitment Status : Unknown Verified May 2015 by Eloise Lemon, Akron Children's Hospital. Recruitment status was: Recruiting First Posted : March 25

2015 Clinical Trials

196. Topical intranasal corticosteroids and growth velocity in children: a meta-analysis. (PubMed)

Topical intranasal corticosteroids and growth velocity in children: a meta-analysis. There is no consensus regarding the effects on growth velocity of intranasal topical corticosteroid (ITC) use in children. The objective of this study was to determine whether ITC use reduces growth velocity in children with allergic rhinitis (AR).A literature search of the National Center for Biotechnology Information PubMed, EMBASE, SCOPUS, and Cochrane databases from January 1, 1988 to October 7, 2013

2015 International forum of allergy & rhinology

197. A phase 3, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of alitretinoin (BAL4079) in the treatment of severe chronic hand eczema refractory to potent topical corticosteroid therapy. (PubMed)

A phase 3, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of alitretinoin (BAL4079) in the treatment of severe chronic hand eczema refractory to potent topical corticosteroid therapy. Severe chronic hand eczema (sCHE) is a persistent, disfiguring disease that responds poorly to conventional treatment and causes substantial physical and psychological disability. The objective of this study was to evaluate efficacy and safety of oral alitretinoin in sCHE (...) in a Phase 3, multicenter, randomized, double-blind, placebo-controlled, parallel-group study comparing alitretinoin with placebo. Efficacy was assessed every 4 weeks during treatment and 4 weeks after end of treatment (EOT, 24 weeks); responders were assessed every 4 weeks for a further 48 weeks after EOT. The study was conducted at academic and private dermatology centers. The participants were 596 patients with sCHE refractory to potent topical corticosteroids. Patients were treated with daily oral

2015 Journal of drugs in dermatology : JDD Controlled trial quality: predicted high

198. Corticosteroid injections for tennis elbow

in well adults? What does the research evidence say? Step 1: The Cochrane Library The Cochrane Library has only a protocol for a review, but no systematic reviews exist. Step 2: TripDatabase & PubMed Next, I conducted a search using the TripDatabase PICO search tool (P: “tennis elbow”, I: “corticosteroid”, C: “placebo”, O: blank). This gave many results to evidence syntheses on the topic, but directly to the paper. I next did a search in PubMed: “lateral epicondylitis” and “corticosteroid (...) Corticosteroid injections for tennis elbow Corticosteroid injections for tennis elbow – Morsels of Evidence \t\t\t\r\n\t\t\t \t\t\t\r\n\t\t\t Like this: Like Loading... ","author":{"@type":"Person","name":"Michael Tam"},"image":["https:\/\/evidencebasedmedicine.com.au\/wp-content\/uploads\/2015\/09\/mo_cover.png"]} Toggle search form Toggle navigation Evidence-based medicine for general practitioners Sep 04 2015 Corticosteroid injections for tennis elbow By in , , , Journal reference: Olaussen

2015 Morsels of Evidence

199. Topical tacrolimus for atopic dermatitis. (PubMed)

Topical tacrolimus for atopic dermatitis. Atopic dermatitis (AD) (or atopic eczema) is a chronic inflammatory skin condition that affects children and adults and has an important impact on quality of life. Topical corticosteroids (TCS) are the first-line therapy for this condition; however, they can be associated with significant adverse effects when used chronically. Tacrolimus ointment (in its 2 manufactured strengths of 0.1% and 0.03%) might be an alternative treatment. Tacrolimus, together (...) absorption. We evaluated clinical trials; case reports; and in vivo, in vitro, and animal studies; and didn't find any evidence that topical tacrolimus could cause skin atrophy.Tacrolimus 0.1% was better than low-potency corticosteroids, pimecrolimus 1%, and tacrolimus 0.03%. Results were equivocal when comparing both dose formulations to moderate-to-potent corticosteroids. Tacrolimus 0.03% was superior to mild corticosteroids and pimecrolimus. Both tacrolimus formulations seemed to be safe

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2015 Cochrane

200. Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis. (PubMed)

antihistamines) inhibit the action of histamine by blocking histamine H1 receptors, antagonising the vasoconstrictor, and to a lesser extent, the vasodilator effects of histamine. Mast cell stabilisers inhibit degranulation and consequently the release of histamine by interrupting the normal chain of intracellular signals. Topical treatments include eye drops with antihistamines, mast cell stabilisers, non-steroidal anti-inflammatory drugs, combinations of the previous treatments, and corticosteroids (...) Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis. Seasonal/perennial allergic conjunctivitis is the most common allergic conjunctivitis, usually with acute manifestations when a person is exposed to allergens and with typical signs and symptoms including itching, redness, and tearing. The clinical signs and symptoms of allergic conjunctivitis are mediated by the release of histamine by mast cells. Histamine antagonists (also called

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2015 Cochrane

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