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Topical Corticosteroid

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181. Ocular side-effects of topical corticosteroids: what a dermatologist needs to know. (PubMed)

Ocular side-effects of topical corticosteroids: what a dermatologist needs to know. Topical corticosteroids are used frequently in dermatology and atopic dermatitis without significant adverse effects. Though ocular diseases such as glaucoma and cataracts are known complications of systemic corticosteroids, the role of topical corticosteroids is limited to case reports. This review assesses the literature regarding topical steroids and their role in ocular diseases. There is evidence of harm (...) to vision when potent topical corticosteroids are inappropriately used for prolonged periods to periorbital sites. There is no evidence to date that weak TCS to the face or potent TCS to areas other than the eyes results in ocular complications. Further research trials are required in this area. © 2015 The Australasian College of Dermatologists.

2015 Australasian Journal of Dermatology

182. Evaluation of Fluid Retention Due to Superpotent Topical Corticosteroid

Evaluation of Fluid Retention Due to Superpotent Topical Corticosteroid Evaluation of Fluid Retention Due to Superpotent Topical Corticosteroid - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Evaluation (...) of Fluid Retention Due to Superpotent Topical Corticosteroid (RECOPB) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02360202 Recruitment Status : Recruiting First Posted : February 10, 2015 Last Update Posted : August 30

2015 Clinical Trials

183. Impact of saline irrigation and topical corticosteroids on the postsurgical sinonasal microbiota. (PubMed)

Impact of saline irrigation and topical corticosteroids on the postsurgical sinonasal microbiota. Topical treatments with nasal saline irrigation, topical steroid sprays, or corticosteroid rinses can improve sinonasal symptoms in chronic rhinosinusitis (CRS). However, the impact of these therapies on commensals (Corynebacterium) and on biofilm pathogens associated with CRS (Staphylococcus aureus and Pseudomonas) is not well characterized.Paired nasal and sinus swabs were collected (...) endoscopically from 28 controls and 14 CRS patients with nasal polyposis (CRSwNP) who had not received systemic antibiotics or corticosteroids in the previous 8 weeks. Total DNA from swab eluents were extracted and analyzed by 16S rRNA gene-based pyrosequencing. A total of 359,077 reads were obtained and classified taxonomically. The association of use of topical therapies with sinonasal microbiota composition was assessed by factor/vector-fitting. The proportional abundances of sinonasal bacteria between

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2015 International forum of allergy & rhinology

184. Pharmacists' knowledge about use of topical corticosteroids in atopic dermatitis: Pre and post continuing professional development education. (PubMed)

Pharmacists' knowledge about use of topical corticosteroids in atopic dermatitis: Pre and post continuing professional development education. Topical corticosteroids (TCS) are the standard of care in paediatric atopic dermatitis (pAD). Parents commonly cite TCS phobia as a major impediment to treatment adherence. Misinformation on TCS side-effects can impact on perceptions of TCS safety. We aimed to assess pharmacists' beliefs and information on the safety of TCS in pAD treatment and determine

2015 Australasian Journal of Dermatology

185. Silver Nitrate Application and Topical Corticosteroids for Hypergranulation Tissue

Silver Nitrate Application and Topical Corticosteroids for Hypergranulation Tissue Silver Nitrate Application and Topical Corticosteroids for Hypergranulation Tissue - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Silver Nitrate Application and Topical Corticosteroids for Hypergranulation Tissue The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02398539 Recruitment Status : Unknown Verified May 2015 by Eloise Lemon, Akron Children's Hospital. Recruitment status was: Recruiting First Posted : March 25

2015 Clinical Trials

186. Topical intranasal corticosteroids and growth velocity in children: a meta-analysis. (PubMed)

Topical intranasal corticosteroids and growth velocity in children: a meta-analysis. There is no consensus regarding the effects on growth velocity of intranasal topical corticosteroid (ITC) use in children. The objective of this study was to determine whether ITC use reduces growth velocity in children with allergic rhinitis (AR).A literature search of the National Center for Biotechnology Information PubMed, EMBASE, SCOPUS, and Cochrane databases from January 1, 1988 to October 7, 2013

2015 International forum of allergy & rhinology

187. A phase 3, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of alitretinoin (BAL4079) in the treatment of severe chronic hand eczema refractory to potent topical corticosteroid therapy. (PubMed)

A phase 3, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of alitretinoin (BAL4079) in the treatment of severe chronic hand eczema refractory to potent topical corticosteroid therapy. Severe chronic hand eczema (sCHE) is a persistent, disfiguring disease that responds poorly to conventional treatment and causes substantial physical and psychological disability. The objective of this study was to evaluate efficacy and safety of oral alitretinoin in sCHE (...) in a Phase 3, multicenter, randomized, double-blind, placebo-controlled, parallel-group study comparing alitretinoin with placebo. Efficacy was assessed every 4 weeks during treatment and 4 weeks after end of treatment (EOT, 24 weeks); responders were assessed every 4 weeks for a further 48 weeks after EOT. The study was conducted at academic and private dermatology centers. The participants were 596 patients with sCHE refractory to potent topical corticosteroids. Patients were treated with daily oral

2015 Journal of drugs in dermatology : JDD

188. Topical combination therapy with vitamin D3 and corticosteroid ointment for palmoplantar pustulosis: A prospective, randomized, left-right comparison study. (PubMed)

Topical combination therapy with vitamin D3 and corticosteroid ointment for palmoplantar pustulosis: A prospective, randomized, left-right comparison study. Vitamin D3 ointment and corticosteroid ointment are both used for the treatment of palmoplantar pustulosis (PPP). However, to date there is no systematic study of the efficacy of combination therapy for the treatment of PPP.We compared the efficacy of a topical combination therapy with vitamin D3 and a topical corticosteroid (...) with that of topical corticosteroid alone in the treatment of PPP.We evaluated left-right comparison study of the efficacy of a combination therapy consisting of maxacalcitol ointment and betamethasone butyrate propionate ointment (BBP), and monotherapy with BBP alone in 27 patients with PPP for 8 weeks.The improvement in the symptom (erythema, pustules/vesicles, hyperkeratosis/scales) scores was high for the combination therapy. In particular, the improvement rate for pustules/vesicles at week 8 after

2015 The Journal of dermatological treatment

189. Cushing's Syndrome in a 6-month-old Boy: A Rare Side-effect due to Inadequate use of Topical Corticosteroids. (PubMed)

Cushing's Syndrome in a 6-month-old Boy: A Rare Side-effect due to Inadequate use of Topical Corticosteroids. 26038976 2016 10 17 2016 12 30 1651-2057 96 1 2016 Jan Acta dermato-venereologica Acta Derm. Venereol. Cushing's Syndrome in a 6-month-old Boy: A Rare Side-effect due to Inadequate use of Topical Corticosteroids. 138-9 10.2340/00015555-2151 Ciccone Sara S Unit of Pediatric Endocrinology and Diabetes, S. Anna Hospital of Ferrara, IT-44124 Ferrara, Italy. sara.ciccone@unife.it. Marini

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2015 Acta Dermato-Venereologica

190. Topical Tacrolimus is equally effective in treating patients with Oral Lichen Planus (OLP) as compared to Topical clobetasol

into 2 groups: twenty patients were assigned the use of clobetasol propionate (0.05%) ointment (topical corticosteroid) twenty patients were assigned the use of tacrolimus (0.1%) ointment (topical immunosuppressant), for eight weeks each. The patients were instructed to apply the ointment twice a day during the treatment period. Both groups were additionally instructed to use chlorhexidine mouthwash three times per day during the 8 week period. All patients were assessed at 2 weeks, 4 weeks and 8 (...) Topical Tacrolimus is equally effective in treating patients with Oral Lichen Planus (OLP) as compared to Topical clobetasol UTCAT2490, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Topical Tacrolimus is Equally Effective in Treating Patients with Oral Lichen Planus (OLP) as Compared to Topical Clobetasol Clinical Question Can topical tacrolimus be used as an alternate to topical clobetasol for treatment of OLP

2013 UTHSCSA Dental School CAT Library

191. Efficacy of Viscosupplementation Associated With Intra-articular Corticosteroid Injection Versus Intra-articular Injection of Corticosteroids Alone in Osteoarthritis of Hip

: November 2015 Actual Study Completion Date : November 2015 Resource links provided by the National Library of Medicine related topics: related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: injection of viscosupplementation and corticosteroid experimental group Device: Experimental group patient receive intra articular injection (hip joint) of viscosupplementation in combination with corticosteroid Active Comparator: injection of corticosteroid control group Device (...) Efficacy of Viscosupplementation Associated With Intra-articular Corticosteroid Injection Versus Intra-articular Injection of Corticosteroids Alone in Osteoarthritis of Hip Efficacy of Viscosupplementation Associated With Intra-articular Corticosteroid Injection Versus Intra-articular Injection of Corticosteroids Alone in Osteoarthritis of Hip - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information

2016 Clinical Trials

192. Combination Corticosteroids+5-aminosalicylic Acids Compared to Corticosteroids Alone (for Ulcerative Colitis).

moderate UC. Thus, in most cases, when a patient with UC experiences a flare while taking 5-ASA therapy, treatment is usually optimized by maximizing the oral dose to 4gr/day and adding topical therapy until the flare is controlled. If this is unhelpful, or if the flare is severe to begin with, corticosteroids are usually prescribed. However, there are very scarce data comparing steroids versus 5-ASA in the treatment of severe UC exacerbation. In 1962 truelove et al compared topical and systemic (...) if the addition of 5-ASA (Oral and/or topical) to corticosteroids will confer additional benefit and improve patients outcomes. Thus, in practical terms, the decision whether to stop or continue 5-ASA treatment or whether to add 5-ASA to steroids in the treatment of moderate-severe UC exacerbation is taken on an arbitrary basis. This is important shortcoming and knowledge gap in current medicine, as patients admitted with moderate-severe UC flare who do not respond to corticosteroids and require salvage

2016 Clinical Trials

193. Ibrutinib in Combination With Corticosteroids vs Placebo in Combination With Corticosteroids in Subjects With New Onset cGVHD

in Combination With Corticosteroids in Subjects With New Onset Chronic Graft Versus Host Disease (cGVHD) (INTEGRATE) Study Start Date : December 2016 Estimated Primary Completion Date : March 2020 Estimated Study Completion Date : March 2020 Resource links provided by the National Library of Medicine related topics: available for: resources: Arms and Interventions Go to Arm Intervention/treatment Experimental: Ibrutinib Ibrutinib in combination with prednisone Drug: ibrutinib Ibrutinib capsules administered (...) Ibrutinib in Combination With Corticosteroids vs Placebo in Combination With Corticosteroids in Subjects With New Onset cGVHD Ibrutinib in Combination With Corticosteroids vs Placebo in Combination With Corticosteroids in Subjects With New Onset cGVHD - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2016 Clinical Trials

194. Late reported clinical trial of the week: Cyclosporine or corticosteroids as an adjunct to plasma exchange in thrombotic thrombocytopenic purpura (NCT00713193)

Late reported clinical trial of the week: Cyclosporine or corticosteroids as an adjunct to plasma exchange in thrombotic thrombocytopenic purpura (NCT00713193) Late reported clinical trial of the week: Cyclosporine or corticosteroids as an adjunct to plasma exchange in thrombotic thrombocytopenic purpura (NCT00713193) - The BMJ ---> Nick DeVito and Ben Goldacre Today we describe a trial that reported late, in breach of the FDA Amendments Act 2007. This late reporting is especially notable (...) ) guidelines are broader: they require all trials of medicinal products registered on their (EUCTR) since 2004 to report results within one year of completion. Our and show all individual trials that breach these legal requirements. Each week we write about one unreported clinical trial: you can read more background , and past entries are . Trials NCT00713193 This week’s late reported trial is titled “A multi-center, randomized study of cyclosporine or corticosteroids as an adjunct to plasma exchange

2018 The BMJ Blog

195. Alternatives to systemic postnatal corticosteroids: Inhaled, nebulized and intratracheal. (PubMed)

Alternatives to systemic postnatal corticosteroids: Inhaled, nebulized and intratracheal. Concern about adverse outcomes with the use of systemic postnatal corticosteroids (PCS) for bronchopulmonary dysplasia (BPD) have led to the widespread use of alternative methods of administration in research and clinical care. Theoretically, administration of topical (directly to the lung) corticosteroids may allow for beneficial effects on the pulmonary system with a lower risk of undesirable side (...) effects compared with systemic administration. Current evidence suggests that inhaled corticosteroids may be an effective therapy in the management of developing BPD in preterm infants, but questions about their safety remain. An alternative to inhalation is the intratracheal administration of corticosteroids using surfactant as a vehicle, but this approach has only been studied in a limited number of infants. We review the evidence for the short-term clinical efficacy and safety of inhaled, nebulized

2019 Seminars in fetal & neonatal medicine

196. Topical tacrolimus for atopic dermatitis. (PubMed)

Topical tacrolimus for atopic dermatitis. Atopic dermatitis (AD) (or atopic eczema) is a chronic inflammatory skin condition that affects children and adults and has an important impact on quality of life. Topical corticosteroids (TCS) are the first-line therapy for this condition; however, they can be associated with significant adverse effects when used chronically. Tacrolimus ointment (in its 2 manufactured strengths of 0.1% and 0.03%) might be an alternative treatment. Tacrolimus, together (...) absorption. We evaluated clinical trials; case reports; and in vivo, in vitro, and animal studies; and didn't find any evidence that topical tacrolimus could cause skin atrophy.Tacrolimus 0.1% was better than low-potency corticosteroids, pimecrolimus 1%, and tacrolimus 0.03%. Results were equivocal when comparing both dose formulations to moderate-to-potent corticosteroids. Tacrolimus 0.03% was superior to mild corticosteroids and pimecrolimus. Both tacrolimus formulations seemed to be safe

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2015 Cochrane

197. Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis. (PubMed)

antihistamines) inhibit the action of histamine by blocking histamine H1 receptors, antagonising the vasoconstrictor, and to a lesser extent, the vasodilator effects of histamine. Mast cell stabilisers inhibit degranulation and consequently the release of histamine by interrupting the normal chain of intracellular signals. Topical treatments include eye drops with antihistamines, mast cell stabilisers, non-steroidal anti-inflammatory drugs, combinations of the previous treatments, and corticosteroids (...) Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis. Seasonal/perennial allergic conjunctivitis is the most common allergic conjunctivitis, usually with acute manifestations when a person is exposed to allergens and with typical signs and symptoms including itching, redness, and tearing. The clinical signs and symptoms of allergic conjunctivitis are mediated by the release of histamine by mast cells. Histamine antagonists (also called

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2015 Cochrane

198. Corticosteroid injections for tennis elbow

in well adults? What does the research evidence say? Step 1: The Cochrane Library The Cochrane Library has only a protocol for a review, but no systematic reviews exist. Step 2: TripDatabase & PubMed Next, I conducted a search using the TripDatabase PICO search tool (P: “tennis elbow”, I: “corticosteroid”, C: “placebo”, O: blank). This gave many results to evidence syntheses on the topic, but directly to the paper. I next did a search in PubMed: “lateral epicondylitis” and “corticosteroid (...) Corticosteroid injections for tennis elbow Corticosteroid injections for tennis elbow – Morsels of Evidence \t\t\t\r\n\t\t\t \t\t\t\r\n\t\t\t Like this: Like Loading... ","author":{"@type":"Person","name":"Michael Tam"},"image":["https:\/\/evidencebasedmedicine.com.au\/wp-content\/uploads\/2015\/09\/mo_cover.png"]} Toggle search form Toggle navigation Evidence-based medicine for general practitioners Sep 04 2015 Corticosteroid injections for tennis elbow By in , , , Journal reference: Olaussen

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2015 Morsels of Evidence

199. Topical Corticosteroids Minimise the Risk of Postinflammatory Hyper-pigmentation After Ablative Fractional CO2 Laser Resurfacing in Asians. (PubMed)

Topical Corticosteroids Minimise the Risk of Postinflammatory Hyper-pigmentation After Ablative Fractional CO2 Laser Resurfacing in Asians. Postinflammatory hyperpigmentation (PIH) is the most common adverse effect of laser treatment in dark-skinned individuals. Little is known whether PIH can be prevented or minimised. The objective of this study was to investigate the effect of short-term application of topical corticosteroids on the incidence of PIH after ablative fractional resurfacing (...) weekly for the first month and at 2 and 3 months post-treatment. The side of the face treated with petrolatum alone had significantly (p < 0.001) higher incidence of PIH (75%) after laser irradiation than the side of the face treated with topical corticosteroids and petrolatum (40%). The PIH occurring on the petrolatum-treated sides had significantly higher intensity (p < 0.001) and was spread over a significantly larger area (p < 0.001), compared with the corticosteroid- and petrolatum-treated sides

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2014 Acta Dermato-Venereologica

200. A randomized controlled clinical trial of topical insulin-like growth factor-1 therapy for sudden deafness refractory to systemic corticosteroid treatment. (PubMed)

A randomized controlled clinical trial of topical insulin-like growth factor-1 therapy for sudden deafness refractory to systemic corticosteroid treatment. To date, no therapeutic option has been established for sudden deafness refractory to systemic corticosteroids. This study aimed to examine the efficacy and safety of topical insulin-like growth factor-1 (IGF-1) therapy in comparison to intratympanic corticosteroid therapy.We randomly assigned patients with sudden deafness refractory (...) to systemic corticosteroids to receive either gelatin hydrogels impregnated with IGF-1 in the middle ear (62 patients) or four intratympanic injections with dexamethasone (Dex; 58 patients). The primary outcome was the proportion of patients showing hearing improvement (10 decibels or greater in pure-tone average hearing thresholds) 8 weeks after treatment. The secondary outcomes included the change in pure-tone average hearing thresholds over time and the incidence of adverse events.In the IGF-1 group

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2014 BMC Medicine

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