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Topical Analgesic

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141. Should non-selective non-steroidal anti-inflammatory drugs (NSAIDs) be avoided following dermatologic surgery? A critically appraised topic with a proposed approach to post-operative analgesia. (Abstract)

Should non-selective non-steroidal anti-inflammatory drugs (NSAIDs) be avoided following dermatologic surgery? A critically appraised topic with a proposed approach to post-operative analgesia. Non-selective non-steroidal anti-inflammatory drugs (NSAIDs) are often avoided by dermatologic surgeons from the historic teaching that they increase post-operative bleeding (POB) through inhibition of platelet aggregation. NSAIDs have two classes: non-selective which inhibit all cyclooxygenase (COX (...) on POB from peer reviewed randomized controlled trials (RCTs) and propose an approach to post-operative pain following dermatologic procedures. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.

2019 Clinical & Experimental Dermatology

142. Topical versus caudal ketamine/bupivacaine combination for postoperative analgesia in children undergoing inguinal herniotomy. Full Text available with Trip Pro

) received either 1 ml/kg of 0.25% bupivacaine/ketamine 0.5 mg/kg for caudal analgesia (caudal group) or 0.3 ml/kg of 0.25% bupivacaine/ketamine 0.5 mg/kg sprayed by the surgeon around the spermatic cord and upon the ilioinguinal nerve before wound closure for topical analgesia (topical group). The duration of postoperative analgesia, pain scores, rescue analgesic consumption, sedation score, hemodynamic monitoring, and side-effects were evaluated 48 h postoperative.Kaplan-Meier survival analysis (...) of analgesia free time demonstrated a significant advantage of topical ketamine (TK) group over caudal ketamine (CK) group. The duration of postoperative analgesia was longer in TK group than in CK group (28.74 ± 2.88 vs. 21.43 ± 5.01 h, P = 0.000). Fewer children asked for oral analgesics in the topical group (24 of 36, 66.7%) than in the caudal one (28 of 32, 87.5%; P < 0.01). Postoperative pain scores at the 6th till 48th h were lower in topical group with comparable analgesic consumption between two

2019 Saudi journal of anaesthesia Controlled trial quality: uncertain

143. Managing Acute Pain in Patients Taking Medications for Opioid Use Disorder

because of the unique pharmacologic properties of these medications and implications for use of additional opioid analgesics. Current guidelines addressing acute pain management in patients taking MOUD are primarily based on expert consensus and do not provide clinicians with detailed recommendations. Given the scope of the opioid crisis and public health response, it is likely that more patients will be treated with MOUD over time. Therefore, determining best practices to manage acute pain (...) after surgery may reduce the total doses of opioids, keeping in mind that patients taking OUD medications are opioid-tolerant and may need higher doses of opioid agonists for effective pain control compared to patients without opioid use disorder; and Ineffective management of acute pain in patients with OUD taking methadone can lead to disengagement in care. Implications Results from this evidence brief were used to inform prioritization of further research at the HSR&D state-of-the-art (SOTA

2019 Veterans Affairs - R&D

144. WHO Guidelines for the pharmacological and radiotherapeutic management of cancer pain in adults and adolescents

GUIDELINES FOR THE PHARMACOLOGICAL AND RADIOTHERAPEUTIC MANAGEMENT OF CANCER PAIN IN ADULTS AND ADOLESCENTS ¦ Analgesia of cancer pain: This addresses the choice of analgesic medicine when initiating pain relief and the choice of opioid for maintenance of pain relief, includ- ing optimization of rescue medication, route of administration, and opioid rotation and cessation. ¦ Adjuvant medicines for cancer pain: This includes the use of steroids, antidepressants and anticonvulsants as adjuvant medicines (...) OF PAIN RELIEF Recommendation In adults (including older persons) and adolescents with pain related to cancer, non-steroidal anti-inflammatory drugs (NSAIDs), paracetamol, and opioids should be used at the stage of initiation of pain management, either alone or in combination, depending on clinical assessment and pain severity in order to achieve rapid, effective and safe pain control. (Strong recommendation; low-quality evidence) Remarks Patients should be started on an analgesic with a strength

2019 World Health Organisation Guidelines

145. An Evaluation of a Customized Insole to Provide Relief From Heel Pain Due to Plantar Fasciitis or General Heel Pain When Used in Footwear Over a Period of Four Weeks

An Evaluation of a Customized Insole to Provide Relief From Heel Pain Due to Plantar Fasciitis or General Heel Pain When Used in Footwear Over a Period of Four Weeks An Evaluation of a Customized Insole to Provide Relief From Heel Pain Due to Plantar Fasciitis or General Heel Pain When Used in Footwear Over a Period of Four Weeks - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x (...) in footwear over a 4-week period of time Condition or disease Intervention/treatment Phase Foot Orthoses Device: BPI1000013 Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 102 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: An Evaluation of a Customized Insole to Provide Relief From Heel Pain Due to Plantar Fasciitis or General Heel Pain When

2018 Clinical Trials

146. A Study to Describe Pain Intensity, Pain Relief and Safety of Neosaldina in the Treatment of Tension-type Headaches (TTH) in Healthy Participants

A Study to Describe Pain Intensity, Pain Relief and Safety of Neosaldina in the Treatment of Tension-type Headaches (TTH) in Healthy Participants A Study to Describe Pain Intensity, Pain Relief and Safety of Neosaldina in the Treatment of Tension-type Headaches (TTH) in Healthy Participants - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save (...) Description: This is an observational, non-interventional and prospective study of healthy participants with episodic TTH who have already been treated with Neosaldina according to regular clinical practice. This study will assess the pain intensity and pain relief of TTH after the uptake of Neosaldina. This study will enroll approximately 317 participants. All participants will be enrolled into one observational group: • Neosaldina Investigators will assess participants from the time of enrolment through

2018 Clinical Trials

147. Pain Relief in Patients With Chronic Low Back Pain Using HeatTens vs. Standard Care.

Pain Relief in Patients With Chronic Low Back Pain Using HeatTens vs. Standard Care. Pain Relief in Patients With Chronic Low Back Pain Using HeatTens vs. Standard Care. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) with chronic low back pain. A sample of 70 patients will be recruited. Following baseline measurements, subjects will be randomly allocated to the experimental or the control group. The experimental group will be asked to use the device on a daily basis, 30 minutes per day. The control group will have no device. After 4 weeks of FU, measurements will be repeated. Condition or disease Intervention/treatment Phase Chronic Low Back Pain Movement Evoked Pain Device: HeatTens (HV-F311-E) Not Applicable Study

2018 Clinical Trials

148. An Evaluation of a Gender Specific Insole to Provide Relief From Knee Pain Due to Osteoarthritis or General Anterior Knee Pain in Male Subjects When Used in Foot Wear Over a Period of Four Weeks

An Evaluation of a Gender Specific Insole to Provide Relief From Knee Pain Due to Osteoarthritis or General Anterior Knee Pain in Male Subjects When Used in Foot Wear Over a Period of Four Weeks An Evaluation of a Gender Specific Insole to Provide Relief From Knee Pain Due to Osteoarthritis or General Anterior Knee Pain in Male Subjects When Used in Foot Wear Over a Period of Four Weeks - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer (...) to provide relief from pain due to osteoarthritis of the knee or general knee pain when used in foot wear for a 4-week period of time. The secondary objectives comprise the evaluation of the insole's ability to provide appropriate shoe fit and comfort as well as relief from osteoarthritis/ general knee pain after short-term use. The safety and tolerability of the test articles in terms of adverse events (AE) will also be investigated. Condition or disease Intervention/treatment Phase Osteoarthritis, Knee

2018 Clinical Trials

149. Analgesic Efficacy of Interscalene Nerve Block Versus Local Infiltration Analgesia Following Total Shoulder Arthroplasty

: Treatment Official Title: Prospective, Randomized Controlled Trial Comparing Analgesic Efficacy of Single Injection vs. Continuous Interscalene Blockade vs. Local Infiltration Analgesia for Patients Undergoing Primary Total Shoulder Arthroplasty Study Start Date : November 2016 Actual Primary Completion Date : February 2018 Actual Study Completion Date : February 2018 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment (...) Analgesic Efficacy of Interscalene Nerve Block Versus Local Infiltration Analgesia Following Total Shoulder Arthroplasty Analgesic Efficacy of Interscalene Nerve Block Versus Local Infiltration Analgesia Following Total Shoulder Arthroplasty - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2016 Clinical Trials

150. Best Practices for Pain Management in Infants, Children, Adolescents, and Individuals with Special Health Care Needs

. • To avoid diversion of controlled substances, practitioners should utilize prescription monitoring databases and encourage patients to properly discard any unused medications. • Providers should be knowledgeable of risks associated with analgesic medications prescribed and anticipate and manage adverse effects (e.g., asthma and NSAIDs, sedation and opioids.) • Seeking expert consultation for patients with chronic pain or other complicated pain condition should be considered. • Providers should (...) reduce pain after treatment? Cochrane Database of Syst Rev 2014;(12):CD009742. 57. Landier WN, Tse A. Use of complementary and alter- native medical interventions for the management of procedure-related pain, anxiety, and distress in pediatric oncology: an integrative review. J Pediatr Nurs 2010;25 (6):566-79. 58. Fein A, Zempsky WT, Cravero JP. Relief of pain and anxiety in pediatric patient in emergency medical systems. Pediatrics 2012;130(5):1391-405. 59. Lewin D, Dahl R. Importance of sleep

2018 American Academy of Pediatric Dentistry

151. Conservative interventions provide short-term relief for non-specific neck pain: a systematic review

Conservative interventions provide short-term relief for non-specific neck pain: a systematic review Conservative interventions provide short-term relief for non-specific neck pain: a systematic review Conservative interventions provide short-term relief for non-specific neck pain: a systematic review Leaver AM, Refshauge KM, Maher CG, McAuley JH CRD summary This review found that some conservative interventions for non-specific neck pain improved pain or disability in the short term (...) , but not in the long term. These conclusions appear to be reliable, but the review was limited by its failure to measure and explore statistical variation between the included trials. Authors' objectives To evaluate the effectiveness of interventions for non-specific neck pain in reducing pain and disability. Searching MEDLINE, CINAHL, EMBASE, PEDro and Cochrane Central Register of Controlled Trials (CENTRAL) were searched for articles from their inception to February 2008. Search terms were reported in an online

2010 DARE.

152. A dose-response study of topical allyl-isothiocyanate (mustard oil) as human surrogate model of pain, hyperalgesia, and neurogenic inflammation. Full Text available with Trip Pro

A dose-response study of topical allyl-isothiocyanate (mustard oil) as human surrogate model of pain, hyperalgesia, and neurogenic inflammation. Despite being a ubiquitous animal pain model, the natural TRPA1-agonist allyl isothiocyanate (AITC, also known as "mustard oil") has only been sparsely investigated as a potential human surrogate model of pain, sensitization, and neurogenic inflammation. Its dose-response as an algogenic, sensitizing irritant remains to be elucidated in human skin (...) a significant dose-dependent increase with a ceiling effect from 50% to 90%. Topical AITC application produces pain and somatosensory sensitization in a dose-dependent manner with optimal concentrations recommended to be >10% and ≤50%. The model is translatable to humans and could be useful in pharmacological proof-of-concept studies of TRPA1-antagonists, analgesics, and anti-inflammatory compounds or for exploratory clinical purposes, eg, loss- or gain-of-function in peripheral neuropathies.

2017 Pain

153. Comparison of Topical Lidocaine Spray With Placebo for Pain Relief in Colposcopic Procedures: A Randomized, Placebo-Controlled, Double-Blind Study. (Abstract)

Comparison of Topical Lidocaine Spray With Placebo for Pain Relief in Colposcopic Procedures: A Randomized, Placebo-Controlled, Double-Blind Study. To compare the effectiveness of topical lidocaine spray compared to a placebo for relieving pain during colposcopic cervical biopsies and endocervical curettage.This randomized, placebo-controlled, double-blind study included patients with abnormal cervical cytologic results requiring colposcopy and directed cervical punch biopsy with or without (...) endocervical curettage (ECC). The patients were randomly assigned to either the 10% lidocaine spray or the placebo group. The patients were asked to rate the pain level immediately after the cervical biopsy and ECC, and mean pain scores of the 2 groups were compared.A total of 214 women were included in the study: 104 in the lidocaine group and 110 in the control group. Age, parity, and history of previous vaginal delivery and cesarean section were similar in both groups. Mean ± SD age was 41.5 ± 10.6

2014 Journal of lower genital tract disease Controlled trial quality: uncertain

154. The efficacy of topical bupivacaine and triamcinolone acetonide injection in the relief of pain after endoscopic submucosal dissection for gastric neoplasia: a randomized double-blind, placebo-controlled trial. (Abstract)

The efficacy of topical bupivacaine and triamcinolone acetonide injection in the relief of pain after endoscopic submucosal dissection for gastric neoplasia: a randomized double-blind, placebo-controlled trial. Although pain is a common complication of endoscopic submucosal dissection (ESD), management strategies are inadequate. The aim of this study was to evaluate the efficacy of topical bupivacaine and triamcinolone acetonide for abdominal pain relief and as a potential method of pain (...) score at 6 h.Bupivacaine after ESD was effective for pain relief at 6 h postoperatively. Particularly, topical infiltration of bupivacaine mixed with triamcinolone acetonide was helpful for producing a more long-lasting benefit of pain relief after gastric ESD.

2014 Surgical endoscopy Controlled trial quality: predicted high

155. Topical bupivacaine compared to bupivacaine infiltration for post-tonsillectomy pain relief in children: a prospective randomized controlled clinical study. (Abstract)

Topical bupivacaine compared to bupivacaine infiltration for post-tonsillectomy pain relief in children: a prospective randomized controlled clinical study. The objective of this study is to compare the topical administration of bupivacaine hydrochloride, saline and bupivacaine hydrochloride infiltration on post-tonsillectomy pain in children. Sixty children undergoing tonsillectomy were enrolled in the study. Patients were randomized into three groups using sealed envelopes. Group 1 (n = 20 (...) to bupivacaine hydrochloride infiltration group at 5th, 13th, 17th hours and 2nd, 3rd, 4th and 5th day (p < 0.017). There were significantly lesser morbidities in topical bupivacaine hydrochloride than saline group in 1st and 4th day (p < 0.017). Topical administration of bupivacaine hydrochloride proved to provide more efficient pain control than bupivacaine hydrochloride infiltration.

2014 European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery Controlled trial quality: uncertain

156. Topical Anti‐Inflammatory and Analgesic Effects of Multiple Applications of S(+)‐Flurbiprofen Plaster (SFPP) in a Rat Adjuvant‐Induced Arthritis Model Full Text available with Trip Pro

Topical Anti‐Inflammatory and Analgesic Effects of Multiple Applications of S(+)‐Flurbiprofen Plaster (SFPP) in a Rat Adjuvant‐Induced Arthritis Model Preclinical Research The aim of this study was to evaluate the efficacy of multiple applications of S(+)-flurbiprofen plaster (SFPP), a novel Nonsteroidal anti-inflammatory drug (NSAID) patch, for the alleviation of inflammatory pain and edema in rat adjuvant-induced arthritis (AIA) model as compared to other NSAID patches. The AIA model (...) was induced by the injection of Mycobacterium butyricum and rats were treated with a patch (1.0 cm × 0.88 cm) containing each NSAID (SFP, ketoprofen, loxoprofen, diclofenac, felbinac, flurbiprofen, or indomethacin) applied to the paw for 6 h per day for 5 days. The pain threshold was evaluated using a flexion test of the ankle joint, and the inflamed paw edema was evaluated using a plethysmometer. cyclooxygenase (COX)-1 and COX-2 inhibition was evaluated using human recombinant proteins. Multiple

2016 Drug development research

157. Skin matters! The role of keratinocytes in nociception: a rational argument for the development of topical analgesics Full Text available with Trip Pro

, more or less as a slow-release formulation, such as in patches delivering opioids. We will discuss this prejudice and show that there are multiple important targets in the skin to be reached by topical analgesic or anti-inflammatory compounds, and that the keratinocyte is one of those targets. By specifically targeting the keratinocyte, analgesia seems possible, effective, and safe, and thus topical analgesic creams may hold promise as a novel treatment modality for neuropathic pain. (...) Skin matters! The role of keratinocytes in nociception: a rational argument for the development of topical analgesics Treatment of neuropathic pain using topical formulations is still in its infancy. Only few topical analgesic formulations have become available for clinical use, and among these, analgesic creams are still rare. This is unfortunate because analgesic creams offer a number of advantages over patches, such as convenience, ease of adapting the frequency of application, and dose

2016 Journal of pain research

158. Comparison of Topical Analgesic With Saline Rinses in Post Extraction Healing

): Rabia Ali, Aga Khan University Study Details Study Description Go to Brief Summary: The aim of this study is to determine the beneficial effect of mouth rinses, both topical analgesic and saline regimens as an adjuvant therapy in the presence of standard prescription of post-operative pain killers on the progress of socket healing following routine dental extraction. Condition or disease Intervention/treatment Phase Periodontitis Dental Caries Hypertension Drug: analgesic mouth rinses (dissolved (...) Comparison of Topical Analgesic With Saline Rinses in Post Extraction Healing Comparison of Topical Analgesic With Saline Rinses in Post Extraction Healing - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2016 Clinical Trials

159. Analgesic effect of topical oral capsaicin gel in burning mouth syndrome. (Abstract)

Analgesic effect of topical oral capsaicin gel in burning mouth syndrome. To investigate the effectiveness of repeated topical application of oral capsaicin gel in two different concentrations for relief of burning/stinging sensations in patients with burning mouth syndrome (BMS).This randomized double-blind cross-over study included 22 female patients with BMS. The patients were randomized for topical application of either 0.01% or 0.025% oral capsaicin gel on the dorsal part of tongue three (...) times daily for 14 days, followed by 14 days wash-out period, and finally treatment with the other concentration of oral gel three times daily for 14 days. A visual analogue scale (VAS) was used to assess the severity of pain five times during the intervention period.18 patients completed the intervention. Their VAS score at baseline was 5.5 ± 0.6 cm (mean ± SD). Treatment with the two concentrations of capsaicin gels significantly improved the burning/stinging symptoms assessed on VAS compared

2016 Acta odontologica Scandinavica Controlled trial quality: uncertain

160. Interventional Spine and Pain Procedures in Patients on Antiplatelet and Anticoagulant Medications

Procite Reference Manager Save my selection doi: 10.1097/AAP.0000000000000700 CHRONIC AND INTERVENTIONAL PAIN: SPECIAL ARTICLE Free The American Society of Regional Anesthesia and Pain Medicine (ASRA) 2012 survey of meeting attendees showed that existing ASRA anticoagulation guidelines for regional anesthesia were insufficient for their needs. Those surveyed agreed that procedure-specific and patient-specific factors required separate guidelines for pain and spine procedures. In response, a guidelines (...) to patient safety and improved outcomes. For example, SCS lead placement requires the use of large-gauge needles with a long bevel and stiff styletted leads to enhance directional control. In many cases, the technique is simple with little tissue stress. However, multiple needle and lead insertions can occur, exposing the epidural space to significant trauma. Patients with neck or back pain undergoing ESIs or other spinal interventions may have significant spinal abnormalities including spinal stenosis

2018 American Society of Regional Anesthesia and Pain Medicine

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