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Topical Analgesic

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141. Comparing Five Oral Analgesics for Treatment of Acute Pain in the ED

hours Any other prescribed or over the counter topical or oral analgesics taken in past 24 hrs Pregnancy by either urine or serum HCG testing Breastfeeding per patient report History of peptic ulcer disease Medical condition that might affect metabolism of opioid analgesics, acetaminophen, or ibuprofen such as hepatitis, renal insufficiency, hypo- or hyperthyroidism, Addison's, or Cushing's disease Lacerations, Multiple injuries Taking any medicine that might interact with one of the study (...) Comparing Five Oral Analgesics for Treatment of Acute Pain in the ED Comparing Five Oral Analgesics for Treatment of Acute Pain in the ED - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Comparing Five Oral

2017 Clinical Trials

142. Physical Performance and Analgesic Effects of tDCS in Primary Dysmenorrhea

Physical Performance and Analgesic Effects of tDCS in Primary Dysmenorrhea Physical Performance and Analgesic Effects of tDCS in Primary Dysmenorrhea - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Physical (...) Performance and Analgesic Effects of tDCS in Primary Dysmenorrhea The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03184740 Recruitment Status : Completed First Posted : June 14, 2017 Last Update Posted : September 12, 2017 Sponsor: Universidade Federal do Rio Grande do Norte Information provided

2017 Clinical Trials

143. Pilot Study Comparing Two Techniques of Taking Care Analgesic in Patients 70 and Older, Awaiting Surgery After Extracapsular Fracture of the Proximal Femur

Pilot Study Comparing Two Techniques of Taking Care Analgesic in Patients 70 and Older, Awaiting Surgery After Extracapsular Fracture of the Proximal Femur Pilot Study Comparing Two Techniques of Taking Care Analgesic in Patients 70 and Older, Awaiting Surgery After Extracapsular Fracture of the Proximal Femur - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record (...) Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Pilot Study Comparing Two Techniques of Taking Care Analgesic in Patients 70 and Older, Awaiting Surgery After Extracapsular Fracture of the Proximal Femur (ALGOFRACT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S

2017 Clinical Trials

144. A Study to Assess the Analgesic Efficacy and Safety of ASP8062 in Subjects With Fibromyalgia

A Study to Assess the Analgesic Efficacy and Safety of ASP8062 in Subjects With Fibromyalgia A Study to Assess the Analgesic Efficacy and Safety of ASP8062 in Subjects With Fibromyalgia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. A Study to Assess the Analgesic Efficacy and Safety of ASP8062 in Subjects With Fibromyalgia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03092726 Recruitment Status : Completed First Posted : March 28, 2017 Last Update Posted : March 26, 2018 Sponsor: Astellas Pharma

2017 Clinical Trials

145. Analgesic Effects of Transversus Thoracic Plane (TTP) Block in Cardiac Surgery

: Analgesic Effects of Transversus Thoracic Plane (TTP) Block in Cardiac Surgery - Pilot Study Estimated Study Start Date : October 1, 2017 Estimated Primary Completion Date : May 1, 2018 Estimated Study Completion Date : May 1, 2018 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: The nerve block group TTP block under dynamic ultrasound guidance plus the standard care (hydromorphone, fentanyl (...) Analgesic Effects of Transversus Thoracic Plane (TTP) Block in Cardiac Surgery Analgesic Effects of Transversus Thoracic Plane (TTP) Block in Cardiac Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2017 Clinical Trials

146. Sucrose: Analgesic or placebo?

Sucrose: Analgesic or placebo? Sucrose: Analgesic or placebo? - First10EM Search Sucrose: Analgesic or placebo? by | Published - Updated | It is time for a (potentially unpopular) rant. Over the last few months, the topic of using sucrose for pain control in neonates has come up a number of times. It has been called the standard of care. It has been stated that it is unethical to run any more trials with a non-treatment arm, because we know that sucrose works. I have a problem (...) capable of reporting a pain scale. We have better options that should be used. We have topical anesthetics, intranasal fentanyl, and all the real analgesics we use in adults. I have seen far too many infants put through an LP without lidocaine or any analgesic, because the focus was shoving a sucrose covered pacifier in their mouth to stop the crying. We wouldn’t do that with an adult; I am not sure why we allow it in infants. I think it is fair to use sucrose in any condition that you would

2017 First10EM

147. Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients.

Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients. The aim of this project was to develop clinical practice guidelines on the use of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the prevention and management of oral mucositis (OM) in cancer patients.A systematic review of the available literature was conducted. The body of evidence for the use of each agent, in each setting (...) &N RT) patients. Recommendations were developed against the use of topical antimicrobial agents for the prevention of mucositis. These included recommendations against the use of iseganan for mucositis prevention in HSCT and H&N RT and against the use of antimicrobial lozenges (polymyxin-tobramycin-amphotericin B lozenges/paste and bacitracin-clotrimazole-gentamicin lozenges) for mucositis prevention in H&N RT. Recommendations were developed against the use of the mucosal coating agent sucralfate

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2017 Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

148. Opioids, Driving and Implications for Youth (Topic Summary)

and Implications for Youth (Topic Summary) ? Stimulants, Driving and Implications for Youth (Topic Summary) Selected References Dubois, S., Bédard, M., & Weaver, B. (2010). The association between opioid analgesics and unsafe driving actions preceding fatal crashes. Accident Analysis and Prevention, 42, 30-37 Julien, R.M., Advokat, C.D., & Comaty, J.E. (2010). A primer of drug action. A comprehensive guide to the actions, uses, and side effects of psychoactive drugs. New York: Worth Publishers. Orriols, L (...) Opioids, Driving and Implications for Youth (Topic Summary) www.ccsa.ca • www.cclt.ca Canadian Centre on Substance Abuse • Centre canadien de lutte contre les toxicomanies Page 1 Topic Summary Opioids, Driving and Implications for Youth This summary is one in a series of four that briefly review the current state of scientific evidence on the effects of various classes of drugs on driving behaviour, while highlighting implications for young drivers. This summary focuses on opioids (also

2015 Canadian Centre on Substance Abuse

149. Topical Lignocaine Patches in Traumatic Rib Fractures

with isolated traumatic rib fractures] are [topical lignocaine patches] effective [in reducing pain and opiate analgesic use]? Clinical Scenario A 76 year old man presents to the Emergency Department with multiple rib fractures after falling down stairs. His pain is difficult to manage, despite intravenous opioids. You speak to the acute pain team for advice on how to manage his pain. They suggest using 5% lignocaine patches over the site of maximal pain. Search Strategy Medline 1946 to November week 4 2013 (...) and weaknesses in their methodology. Patients included in the studies were polytrauma patients with the presence of other significant injuries, therefore we cannot comment on the effect of lignocaine patches on pain control and opiate use in isolated rib injuries. Clinical Bottom Line Currently, there is no evidence to support the use of topical lignocaine patches to improve pain control and reduce opiate analgesic use, in patients with traumatic rib fractures. A prospectively designed trial with a large

2015 BestBETS

150. The European Society of Regional Anaesthesia and Pain Therapy and the American Society of Regional Anesthesia and Pain Medicine Joint Committee Practice Advisory on Controversial Topics in Pediatric Regional Anesthesia

The European Society of Regional Anaesthesia and Pain Therapy and the American Society of Regional Anesthesia and Pain Medicine Joint Committee Practice Advisory on Controversial Topics in Pediatric Regional Anesthesia The European Society of Regional Anaesthesia and Pain Therap... : Regional Anesthesia and Pain Medicine You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page. Login No user account? Lippincott Journals Subscribers (...) sent to your colleague. Some error has occurred while processing your request. Please try after some time. Export to End Note Procite Reference Manager Save my selection doi: 10.1097/AAP.0000000000000280 SPECIAL ARTICLES Free Background and Objectives Some topics in the clinical management of regional anesthesia in children remain controversial. To evaluate and come to a consensus regarding some of these topics, The European Society of Regional Anaesthesia and Pain Therapy (ESRA) and the American

2015 American Society of Regional Anesthesia and Pain Medicine

151. Topical Transdermally Delivered Lidocaine and Benzocaine Compared to Compounded Lidocaine/Tetracaine During Microfocused Ultrasound With Visualization Treatment. (PubMed)

Topical Transdermally Delivered Lidocaine and Benzocaine Compared to Compounded Lidocaine/Tetracaine During Microfocused Ultrasound With Visualization Treatment. The efficacy of various pre-medication strategies for comfort management during microfocused ultrasound with visualization (MFU-V) treatment has not been studied. The present objective was to compare 2 topical analgesics (lidocaine 4% and benzocaine 20%) formulated with a novel transdermal delivery system with compounded lidocaine 23

2018 Journal of drugs in dermatology : JDD

152. A prospective randomized double-blind study of pain control by topical calcium channel blockers versus placebo after Milligan-Morgan hemorrhoidectomy. (PubMed)

A prospective randomized double-blind study of pain control by topical calcium channel blockers versus placebo after Milligan-Morgan hemorrhoidectomy. Post-hemorrhoidectomy pain is significantly associated with a hypertonicity of the internal anal sphincter. We evaluated the effects of topical diltiazem, a calcium channel blocker, in reducing pain after hemorrhoidectomy. Purpose of our study was to determine difference in extent of pain control by application of topical calcium channel blocker (...) postoperatively and number of analgesic doses consumed by patients in the first 3 days.Patients using the diltiazem ointment had significantly less pain and greater benefit than those in the placebo group throughout the first postoperative week (p < 0.001) except for reading at 6 h. Also, there was significantly less number of analgesic doses consumed in the diltiazem group compared to the placebo group.Perianal application of 2% diltiazem ointment after hemorrhoidectomy significantly reduces postoperative

2018 International journal of colorectal disease

153. Effect of Topical Lidocaine Patch on Postoperative Pain Management in Laparoscopic Appendectomy: A Randomized, Double-Blind, Prospective Study. (PubMed)

Effect of Topical Lidocaine Patch on Postoperative Pain Management in Laparoscopic Appendectomy: A Randomized, Double-Blind, Prospective Study. Adequate pain control is a major concern in the immediate postoperative period. In multiple strategies for postoperative pain management, topical analgesics have significant advantages of minimizing severe side effects caused by oral and parenteral administration and drug-drug interactions. Therefore, we studied the effect of lidocaine patch (...) in the control group (0.10 ± 0.31 mg versus 0.25 ± 0.79 mg, P < .001).The results of this study suggest that lidocaine patch application to the trocar site after laparoscopic appendectomy may have a positive effect on the management of postoperative pain and can eliminate the need to inject additional analgesics for further postoperative pain control.

2018 Journal of laparoendoscopic & advanced surgical techniques. Part A

154. Topical blood stopper agents during adenoid surgery in young children; a prospective randomized controlled trial. (PubMed)

) and normal saline (control group).ABS and FS groups showed a significantly less intra operative blood loss (16.4 ± 2.6/22 ± 6.2), operative time (9.31 ± 1.9/11.2 ± 1.6 min), use of cautery (10.6/25.3%), postoperative analgesics (3 ± 1.1/3.8 ± 1.2), duration to return normal diet (2.4 ± 1.2/3.9 ± 0.9) and operating theatre cost (233 ± 48$ and 279 ± 40$) than the control group.AFS and FS are easy, safe, and reliable topical haemostatic modulators that could be used in adenoid surgery. (...) Topical blood stopper agents during adenoid surgery in young children; a prospective randomized controlled trial. To investigate the safety and efficacy of two topical blood stopper modulators; Ankaferd blood stopper (ABS) and feracrylum 1% solution (FS) during adenoid surgery.Prospective randomized trial.Two hundred and twenty five consecutive pediatric adenoid patients aged from 9 months to 2 years old were studied. Patients were randomly allocated into two haemostatic groups; (ABS, FS

2018 European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

155. Topic anaesthesia with a eutectic mixture of lidocaine/prilocaine cream after elective caesarean section: a randomised, placebo-controlled trial. (PubMed)

Topic anaesthesia with a eutectic mixture of lidocaine/prilocaine cream after elective caesarean section: a randomised, placebo-controlled trial. Aim of the study was to investigate the topical application of a eutectic mixture of lidocaine/prilocaine (EMLA®) cream after caesarean section (CS) and its effect on postoperative pain, time to mobilisation, and time to discharge.A total of 189 pregnant women were enrolled; full data sets were available for 139 of them, who were prospectively (...) randomised to receive either placebo (control group) or EMLA® cream (study group) on the CS lesion directly as well as 24 h after surgery. Postoperative pain was assessed 24 and 48 h after surgery using the short form of the McGill Pain Questionnaire (SF-MPQ). Additional analgesic pain medication on demand was assessed in both groups.A total of 62 women were allocated randomly to the study and 77 patients to the control group before primary CS. There were no statistically significant differences

2018 Archives of gynecology and obstetrics

156. Esthesiometric evaluation of corneal analgesia after topical application of 1% morphine sulfate in normal horses. (PubMed)

Esthesiometric evaluation of corneal analgesia after topical application of 1% morphine sulfate in normal horses. To evaluate whether topical ocular application of 1% morphine sulfate would change corneal sensitivity and to identify the duration of action.Eight healthy adult horses.Corneal touch threshold (CTT) was measured in the center of one randomly selected eye of each horse by Cochet-Bonnet esthesiometer (Luneau Cochet-Bonnet Esthesiometer; Western Ophthalmics, Lynnwood, WA, USA (...) threshold was not statistically different between morphine-treated and control eyes (P = 0.22). There was a large degree of inter- and intrasubject variation in the CTT measurements obtained. All but three horses were considered to be at baseline values by 60 min.Topical ophthalmic 1% morphine sulfate did not have a clinically significant analgesic effect on the corneal touch threshold of intact healthy equine corneas.© 2017 American College of Veterinary Ophthalmologists.

2018 Veterinary ophthalmology

157. Topical lidocaine-prilocaine cream versus lidocaine infiltration for pain relief during repair of perineal tears after vaginal delivery: randomized clinical trial. (PubMed)

Topical lidocaine-prilocaine cream versus lidocaine infiltration for pain relief during repair of perineal tears after vaginal delivery: randomized clinical trial. The current study aims to compare the analgesic effect of lidocaine-prilocaine (LP) cream with lidocaine infiltration during repair of perineal tears after vaginal delivery.A single center open-labeled randomized clinical trial was carried out in a tertiary University Hospital between October 2016 and May 2017 (Clinical Trials.Gov (...) groups (p = .371). More women in the LP cream group were satisfied than the other group with statistical significant difference (76.4 versus 30.6%, p = .000). No difference between side effects in both groups (p = .171) Conclusions: Topical application of lidocaine-prilocaine cream is an effective analgesic during repair of perineal tears with no harmful side effects.

2018 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

158. Effectiveness of Topical Application of Honey on Oral Mucosa of Children for the Management of Oral Mucositis Associated with Chemotherapy. (PubMed)

received routine practice of analgesic and antiseptic gel application whereas children in experimental group also received the topical application of honey on oral mucosa for the management of OM. All children are monitored from the day they developed oral mucositis until the subsidence of signs and symptoms of oral mucositis. The severity of OM was assessed with WHO-STC (Stomatitis Toxicity Criteria) scale by a observer blind.There was statistically significant difference in reduction of severity (...) Effectiveness of Topical Application of Honey on Oral Mucosa of Children for the Management of Oral Mucositis Associated with Chemotherapy. To evaluate the effectiveness of topical application of honey on Oral Mucositis (OM) associated with chemotherapy.An observational blind study is performed upon a sample of 100 children receiving chemotherapy who developed oral mucositis. All children are divided into two groups (control and experimental) who received different regimens. Both groups

2018 Indian journal of pediatrics

159. A randomised field study evaluating the effectiveness of buccal meloxicam and topical local anaesthetic formulations administered singly or in combination at improving welfare of female Merino lambs undergoing surgical mulesing and hot knife tail docking. (PubMed)

A randomised field study evaluating the effectiveness of buccal meloxicam and topical local anaesthetic formulations administered singly or in combination at improving welfare of female Merino lambs undergoing surgical mulesing and hot knife tail docking. This study was a field-based behavioural assessment of the pain responses to surgical mulesing modulated by a buccal formulation of meloxicam (Buccalgesic) and a topical local anaesthetic wound dressing (Tri-Solfen). 20 lambs were randomly (...) , abnormal behaviours were reduced for all groups that received the analgesic drugs compared to the Mules group (P < 0.05). Tri-Solfen reduced expression of abnormal behaviours in the first 4 h; Buccalgesic reduced expression of abnormal behaviours between 2 and 6 h; and combination treatment reduced expression of abnormal behaviours over the entire observation period. On the subsequent two days, the drug combination resulted in fewer abnormal postures than Tri-Solfen alone. The drug combination tended

2018 Research in veterinary science

160. High-concentration topical capsaicin in the management of refractory neuropathic pain in patients with Neurofibromatosis type 1: a case series. (PubMed)

High-concentration topical capsaicin in the management of refractory neuropathic pain in patients with Neurofibromatosis type 1: a case series. The aim of this case series was to report the use of 8% topical capsaicin patch (marketed under the trade name Qutenza®) a in the management of refractory neuropathic pain (NP) in adult patients with type 1 neurofibromatosis (NF1).Capsaicin has been suggested for NF1 patients suffering from refractory peripheral NP despite several years of analgesic (...) : interference scores (QCD), Patient Global Impression of Change (PGIC) and overall treatment satisfaction, self-reported by the patient.Eight patients (5 females/3 males, 41.8 ± 8.2 years of age) received a first treatment with capsaicin. Patients had pre-existing pain for 6.6 years (±6.0) and were currently receiving an average of 6.1 (±3.9) different analgesics. The response rate was 37.5%. The three responders felt globally improved and satisfied, with the improvement in overall condition as interference

2018 Current medical research and opinion

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