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Topical Analgesic

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121. Analgesic Efficacy of Pulsed Radiofrequency in Non-cyclic Mastalgia

, neurological deficits or respiratory insufficiency (dyspnea or pneumothorax).2-Need for analgesic intake was recorded.3-Side effect of Tamoxifen as nausea, vomiting, hot flashes and dizziness.4-Quality of life (The American Chronic Pain Association's Quality of life scale). Condition or disease Intervention/treatment Phase Breast Fibroadenoma Other: pulsed radiofrequency of 2nd , 3rd and 4th thoracic dorsal root ganglia. Drug: Tamoxifen Phase 2 Study Design Go to Layout table for study information Study (...) Type : Interventional (Clinical Trial) Actual Enrollment : 64 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Analgesic Efficacy of Pulsed Radiofrequency in Non-cyclic Mastalgia Actual Study Start Date : August 15, 2018 Actual Primary Completion Date : December 1, 2018 Actual Study Completion Date : December 1, 2018 Resource links provided by the National Library of Medicine related topics: available

2018 Clinical Trials

122. Opioid Analgesics for Acute Fracture Pain in Older Adults Discharged From the ED

are less likely to receive pain medications than younger patients, and this inadequate pain control has been associated with increased risk of delirium and longer hospital stays. Given the concerns for drug interactions, adverse side effects, over-sedation and addiction; emergency physicians often report uncertainty regarding the ideal choice of opioid analgesic in older adults. There are no guidelines informing best practice for the management of acute pain in this population. Objective: The primary (...) , RAs and patients will be blinded to the randomization schedule. Study investigators will be permitted to un-blind the study medication in the event of allergic reaction, consisting of rash and/or airway compromise. Primary Purpose: Treatment Official Title: A Blinded, Randomized Controlled Trial of Opioid Analgesics for the Management of Acute Fracture Pain in Older Adults Discharged From the Emergency Department Actual Study Start Date : February 5, 2018 Estimated Primary Completion Date : August

2018 Clinical Trials

123. Analgesic Effect of Adding an Adductor Canal Block to a Femoral Triangle Block for Total Knee Replacement

Block to a Femoral Triangle Block for Analgesia After Total Knee Replacement Actual Study Start Date : February 22, 2018 Estimated Primary Completion Date : December 2018 Estimated Study Completion Date : December 2018 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Intervention Adductor canal block Femoral triangle block Procedure: Adductor canal block Single shot block with 0.5% bupivacaine 10mls (...) Analgesic Effect of Adding an Adductor Canal Block to a Femoral Triangle Block for Total Knee Replacement Analgesic Effect of Adding an Adductor Canal Block to a Femoral Triangle Block for Total Knee Replacement - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2018 Clinical Trials

124. Changs in Analgesic Duration of Patients With Different Anesthesia Management

: Parallel Assignment Intervention Model Description: thoracic paravertebral blocks using a combination of ropivacaine and dexmedetomidine or dexamethasone Masking: Double (Investigator, Outcomes Assessor) Primary Purpose: Treatment Official Title: Changs in Analgesic Duration of Patients With Different Anesthesia Management Actual Study Start Date : June 26, 2018 Actual Primary Completion Date : February 12, 2019 Actual Study Completion Date : February 12, 2019 Resource links provided by the National (...) Changs in Analgesic Duration of Patients With Different Anesthesia Management Changs in Analgesic Duration of Patients With Different Anesthesia Management - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2018 Clinical Trials

125. Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance

. Condition or disease Intervention/treatment Phase Hemorrhage Healthy Drug: Ketamine Hydrochloride Other: Placebo Phase 4 Detailed Description: Pain management on the battlefield is critical for the wellbeing of the soldier. Given that a hemorrhagic injury on the battlefield is virtually always associated with pain, it is paramount that the selected pain medication does not disrupt appropriate physiological mechanisms that are beneficial towards the maintenance of blood pressure and vital organ blood (...) should be employed for such an injury. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 30 participants Allocation: Non-Randomized Intervention Model: Single Group Assignment Intervention Model Description: single blinded placebo controlled study Masking: Single (Participant) Primary Purpose: Supportive Care Official Title: Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Ketamine Actual Study Start

2018 Clinical Trials

126. Comparison of Two Routes of Administration of a Multimodal Analgesic Protocol in Postoperative Cesarean Section

of Administration of a Multimodal Analgesic Protocol in Postoperative Cesarean Section Oral vs Intravenous Actual Study Start Date : January 1, 2015 Actual Primary Completion Date : June 30, 2015 Actual Study Completion Date : June 30, 2015 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Oral Group received in post operative period oral analgesia ( "nefopam (Acupan)" 20mg/6h, "piroxicam (piroxan)" 40mg/24h (...) Last Update Posted : August 15, 2018 Sponsor: Centre de Maternité de Monastir Information provided by (Responsible Party): Fethi Jebali, Centre de Maternité de Monastir Study Details Study Description Go to Brief Summary: Many drugs with various mechanisms of action are used for postcaesarean pain relief. Although the response to pain relief is sometimes believed to be individual, it is very important to establish the most effective with the least adverse effects type of oral analgesia for women

2018 Clinical Trials

127. Dex as Analgesic Adjuvant in OSA Patients

Controlled Study Evaluating the Use of Intraoperative Dexmedetomidine in Reducing Postoperative Pain and Narcotic Requirement in Patients With Moderate to Severe OSA. Study Start Date : July 2014 Estimated Primary Completion Date : June 2015 Estimated Study Completion Date : June 2015 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Dexmedetomidine Sedation This group will receive 1mcg/kg bolus (...) Study Details Study Description Go to Brief Summary: The purpose of this study is to assess whether intravenous peri-operative Dexmedetomidine reduces opioid requirements and or improves pain control after Uvulopalatopharyngoplasty (UPPP) in patients with obstructive sleep apnea (OSA). Condition or disease Intervention/treatment Phase Obstructive Sleep Apnea Drug: Dexmedetomidine Drug: Placebo Phase 1 Phase 2 Detailed Description: BACKGROUND/STUDY SIGNIFICANCE Patients with OSA undergoing surgery

2018 Clinical Trials

128. Post-Operative Analgesic Effects of Local Wound Infiltration With Ketorolac After Inguinal Herniorrhaphy

24 hours of surgery, the group of patients with surgical site injections suffered less pain than the group of patients with intravenous injection (P<0.02). Besides they discovered that the time to first analgesia in the group of patients with surgical site injection was longer. (P<0.03), and the amount of analgesic requirement that the patients needed in the first 24 hours after surgery was also less in this group. (P<0.0002). According to the research above surgical site injection of Ketorolac (...) into two groups and comparing between Ketorolac and Bupivacaine injection at surgical site. Condition or disease Intervention/treatment Phase Inguinal Herniorrhaphy Pain, Postoperative Other: Ketorolac group Other: Bupivacaine group Not Applicable Detailed Description: The study design is a prospective randomized, double-blind, controlled trial of patients who are undergoing elective unilateral inguinal herniorrhaphy at Ramathibodi Hospital during the period 1 July 2018 - 30 June 2020 The primary

2018 Clinical Trials

129. Randomized controlled trial to compare oral analgesic requirements and patient satisfaction in using oral non-steroidal anti-inflammatory drugs versus benzydamine hydrochloride oral rinses after mandibular third molar extraction: a pilot study Full Text available with Trip Pro

Randomized controlled trial to compare oral analgesic requirements and patient satisfaction in using oral non-steroidal anti-inflammatory drugs versus benzydamine hydrochloride oral rinses after mandibular third molar extraction: a pilot study Third molar extraction is associated with considerable pain and discomfort, which is mostly managed with oral analgesic medication. We assessed the analgesic effect of benzydamine hydrochloride, a topical analgesic oral rinse, for controlling (...) postoperative pain following third molar extraction.A randomized controlled trial was conducted in 40 patients divided into two groups, for extraction of fully erupted third molar. Groups A received benzydamine hydrochloride mouthwash and group B received normal saline gargle with oral ibuprofen and paracetamol. Oral ibuprofen and paracetamol was the rescue analgesic drug in group A. Patients were evaluated on the 3rd and 7th post-operative days (POD) for pain using the visual analogue score (VAS), trismus

2018 Journal of Dental Anesthesia and Pain Medicine Controlled trial quality: uncertain

130. Non-pharmacological Analgesic Effects on Term Newborns

Description Go to Brief Summary: The purpose of this study is to compare the analgesic effects of four non-pharmacological interventions: skin-to-skin contact, breastfeeding, oral sucrose and nonnutritive sucking in newborns receiving a heel lance procedure. Condition or disease Intervention/treatment Phase Pain Breast Feeding Behavioral: breastfeeding Dietary Supplement: oral sucrose Behavioral: Skin-to-Skin contact Behavioral: Non-nutritive sucking Not Applicable Detailed Description (...) : This is an randomized control clinical study. study population is healthy term newborns.Patients were identified by chart review and consent was received by nurse researcher. Newborns were randomized into either the control group who received no pain intervention or the intervention group who received one of four non-pharmacological pain interventions: skin to skin contact, breastfeeding, oral sucrose, and nonnutritive sucking. A heel lance for newborn screen blood sampling was selected as a study procedure

2018 Clinical Trials

131. Optimization of Pre-operative Oral Analgesics in Patients Undergoing Ambulatory Minimally Invasive Hysterectomy

: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Optimization of Pre-operative Oral Analgesics in Patients Undergoing Ambulatory Minimally Invasive Hysterectomy Actual Study Start Date : January 12, 2018 Actual Primary Completion Date : December 21, 2018 Estimated Study Completion Date : June 30, 2019 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Control (...) and SRS. A maximum of 58 patients will be enrolled into the study, as we aim to randomize 26 patients to each arm. Condition or disease Intervention/treatment Phase Hysterectomy Laparoscopy Analgesia Other: Timing of pre-operative oral non-narcotic analgesics in relation to minimally invasive hysterectomy Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 58 participants Allocation: Randomized Intervention Model

2018 Clinical Trials

132. Pain Comparison Whit Visual Analog Scale (EVA) Between Four Analgesic Methods During Trans Rectal Prostatic Biopsy

Pain Comparison Whit Visual Analog Scale (EVA) Between Four Analgesic Methods During Trans Rectal Prostatic Biopsy Pain Comparison Whit Visual Analog Scale (EVA) Between Four Analgesic Methods During Trans Rectal Prostatic Biopsy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Pain Comparison Whit Visual Analog Scale (EVA) Between Four Analgesic Methods During Trans Rectal Prostatic Biopsy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03442075 Recruitment Status : Completed First Posted : February

2018 Clinical Trials

133. A Randomised Controlled Trial of Remifentanil Intravenous Patient Controlled Analgesia (PCA) Versus Intramuscular Pethidine for Pain Relief in Labour

to inadequate pain relief. Epidurals provide highly effective pain relief, but increase the risk of a forceps or suction delivery resulting in prolonged hospital stay. Therefore, there is a clear need for a safe, effective, easy to administer analgesic alternative. Condition or disease Intervention/treatment Phase Pain Relief in Labour Drug: Pethidine Drug: Remifentanil Phase 4 Detailed Description: Patient Controlled Analgesia (PCA) comprises drug administration into an intravenous drip with a small dose (...) A Randomised Controlled Trial of Remifentanil Intravenous Patient Controlled Analgesia (PCA) Versus Intramuscular Pethidine for Pain Relief in Labour A Randomised Controlled Trial of Remifentanil Intravenous Patient Controlled Analgesia (PCA) Versus Intramuscular Pethidine for Pain Relief in Labour - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved

2014 Clinical Trials

134. A prospective randomized double-blind study of pain control by topical calcium channel blockers versus placebo after Milligan-Morgan hemorrhoidectomy. (Abstract)

A prospective randomized double-blind study of pain control by topical calcium channel blockers versus placebo after Milligan-Morgan hemorrhoidectomy. Post-hemorrhoidectomy pain is significantly associated with a hypertonicity of the internal anal sphincter. We evaluated the effects of topical diltiazem, a calcium channel blocker, in reducing pain after hemorrhoidectomy. Purpose of our study was to determine difference in extent of pain control by application of topical calcium channel blocker (...) postoperatively and number of analgesic doses consumed by patients in the first 3 days.Patients using the diltiazem ointment had significantly less pain and greater benefit than those in the placebo group throughout the first postoperative week (p < 0.001) except for reading at 6 h. Also, there was significantly less number of analgesic doses consumed in the diltiazem group compared to the placebo group.Perianal application of 2% diltiazem ointment after hemorrhoidectomy significantly reduces postoperative

2018 International journal of colorectal disease Controlled trial quality: predicted high

135. Effect of Topical Anesthetic Cream on Pain During Periareolar Injection of Technetium Tc99m Sulfur Colloid for Sentinel Lymph Node Biopsy in Breast Cancer: A Randomized Control Trial. (Abstract)

Effect of Topical Anesthetic Cream on Pain During Periareolar Injection of Technetium Tc99m Sulfur Colloid for Sentinel Lymph Node Biopsy in Breast Cancer: A Randomized Control Trial. Injection of Tc99m to localize nodes for sentinel lymph node biopsy is reported by patients as very painful. The purpose of this study was to determine if anesthetic cream reduces pain associated with periareolar injection of Tc99m and to help elucidate conflicting literature regarding the efficacy of anesthetic (...) cream for this procedure.A randomized, double-blind, placebo-controlled methodology was used for adult females with breast cancer undergoing periareolar injection of Tc99m for sentinel lymph node biopsy. Pain levels were compared using anesthetic cream (2.5% lidocaine/2.5% prilocaine) vs. placebo. Patient exclusion criteria included use of opioids or adjuvant pain medication or injecting Tc99m the day before surgery. The Numerical Rating Scale was used to assess pain levels immediately after

2018 Journal of Medical Imaging and Radiation Sciences Controlled trial quality: predicted high

136. A Randomized, Double-Blind, Placebo-Controlled Trial on Clinical Efficacy of Topical Agents in Reducing Pain and Frequency of Recurrent Aphthous Ulcers Full Text available with Trip Pro

A Randomized, Double-Blind, Placebo-Controlled Trial on Clinical Efficacy of Topical Agents in Reducing Pain and Frequency of Recurrent Aphthous Ulcers Recurrent Aphthous Ulcers (RAU) is one of the most common oral ulcerative Disease of the oral mucosa with high recurrence rate. Standard topical treatment options provide symptomatic relief with few have been found to be effective in treating or relieving the symptoms.The study aimed to evaluate the clinical efficacy of various topical agents (...) in order to find the better treatment modality so as to decrease the number, size, exudate level and discomfort associated with pain with RAU.The patients diagnosed with minor recurrent aphthous ulcers fulfilling the inclusion and exclusion criteria were enrolled. All the baseline parameters were measured by the principal investigator. The treatment modality was assigned by generating a randomization list by computer software, double-blinded in consecutively numbered sealed envelopes. The topical

2018 The open dentistry journal Controlled trial quality: predicted high

137. Effectiveness of Topical Lidocaine-Prilocaine Cream for Pain Control During Femoral Artery Catheterization in Adult Patients: A Prospective Study Full Text available with Trip Pro

Effectiveness of Topical Lidocaine-Prilocaine Cream for Pain Control During Femoral Artery Catheterization in Adult Patients: A Prospective Study To test the effectiveness of topical EMLA cream (lidocaine 2.5% and prilocaine 2.5%) for pain control during femoral artery catheterization for neuro-endovascular procedures in adult patients.The body habitus overlying the femoral arterial pulsation was graded as: (1) pubic symphysis and iliac crest bone protuberances visualized; (2) Pubic Symphysis (...) and Iliac Crest bone protuberances not seen but easily palpable; (3) Pubic Symphysis and Iliac Crest bone protuberances palpable with considerable difficulty; and (4) abdominal layers fold over the femoral region. The severity of pain at femoral artery catheterization was classified using a numeric rating scale score ranging from 0 (no pain) to 10 (worst pain). The primary endpoints were the proportion of patients with excellent (score of ≤1) and failed pain control (score of ≥8).The mean (±SD

2018 Journal of vascular and interventional neurology

138. Topic Cervical Anesthesia for Pain Control During Endouterine Manual Aspiration

Topic Cervical Anesthesia for Pain Control During Endouterine Manual Aspiration Topic Cervical Anesthesia for Pain Control During Endouterine Manual Aspiration - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) Enrollment : 86 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Treatment Official Title: Topic Use of Lidocaine Gel Plus Paracervical Blockade vs. Paracervical Blockade Alone for Pain Control During Endouterine Manual Aspiration: A Randomized Controlled Trial Actual Study Start Date : August 1, 2014 Actual Primary Completion Date : September 30, 2014 Actual Study Completion Date

2018 Clinical Trials

139. Randomized phase II placebo-controlled study to evaluate the efficacy of topical pure emu oil for joint pain related to adjuvant aromatase inhibitor use in postmenopausal women with early breast cancer: JUST (Joints Under Study). (Abstract)

Randomized phase II placebo-controlled study to evaluate the efficacy of topical pure emu oil for joint pain related to adjuvant aromatase inhibitor use in postmenopausal women with early breast cancer: JUST (Joints Under Study). Aromatase inhibitors are standard of care in women with hormone receptor-positive early breast cancer. Published evidence demonstrates that adverse effects may have an impact on drug compliance, with arthralgias being one of the most commonly reported adverse (...) benefit with use of EO. However, there was a statistically significant improvement in pain (visual analogue score was -1.28; p < 0.001) and Brief Pain Inventory severity score -0.88 (p < 0.001), as well as functional interference (Brief Pain Inventory interference -1.10 (p < 0.001) for the entire population following an 8-week administration of EO or placebo oil.Arthralgias, as a result of aromatase inhibitor use, may be ameliorated by the use of topical oil massaged onto the joint. Further research

2018 Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer Controlled trial quality: uncertain

140. Should non-selective non-steroidal anti-inflammatory drugs (NSAIDs) be avoided following dermatologic surgery? A critically appraised topic with a proposed approach to post-operative analgesia. (Abstract)

Should non-selective non-steroidal anti-inflammatory drugs (NSAIDs) be avoided following dermatologic surgery? A critically appraised topic with a proposed approach to post-operative analgesia. Non-selective non-steroidal anti-inflammatory drugs (NSAIDs) are often avoided by dermatologic surgeons from the historic teaching that they increase post-operative bleeding (POB) through inhibition of platelet aggregation. NSAIDs have two classes: non-selective which inhibit all cyclooxygenase (COX (...) on POB from peer reviewed randomized controlled trials (RCTs) and propose an approach to post-operative pain following dermatologic procedures. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.

2019 Clinical & Experimental Dermatology

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