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Topical Analgesic

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101. Oral opioid analgesics vs spinal steroid injections in the treatment of low back pain syndromes Full Text available with Trip Pro

with non-neoplastic chronic lower back pain or lumbar radiculopathy. Studies of patients with chronic pain after spinal surgery and studies that focused on partial or synthetic opioid analgesics were included. Primary outcomes were: pain relief measured with a visual analogue scale; functional benefit measured with the Roland-Morris questionnaire or Oswestry Disability Index; quality of life measured with Short-Form 36-item questionnaire; and mortality. Secondary outcome measures were other pain relief (...) Oral opioid analgesics vs spinal steroid injections in the treatment of low back pain syndromes Oral opioid analgesics vs spinal steroid injections in the treatment of low back pain syndromes Oral opioid analgesics vs spinal steroid injections in the treatment of low back pain syndromes Nampiaparampil DE, Nampiaparampil GM, Nampiaparampil RG CRD summary This review found that opioid therapy and percutaneous spinal steroid injections were both helpful for low back pain and disability but high

2012 DARE.

102. Sufentanil for Palliative Pain Relief: A Review of the Clinical Effectiveness, Cost-Effectiveness and Guidelines

of sufentanil for the relief of palliative pain. It identified one poor quality study suggesting that there is insufficient evidence to draw conclusions regarding the clinical effectiveness of sufentanil use in the context of palliative care. In addition, no cost-effectiveness analyses or current evidence-based guidelines were identified on this topic. Tags palliative care, sufentanil, anesthesia, palliative Files Rapid Response Summary with Critical Appraisal Published : November 18, 2015 Related Content (...) Sufentanil for Palliative Pain Relief: A Review of the Clinical Effectiveness, Cost-Effectiveness and Guidelines Sufentanil for Palliative Pain Relief: A Review of the Clinical Effectiveness, Cost-Effectiveness and Guidelines | CADTH.ca Find the information you need Sufentanil for Palliative Pain Relief: A Review of the Clinical Effectiveness, Cost-Effectiveness and Guidelines Sufentanil for Palliative Pain Relief: A Review of the Clinical Effectiveness, Cost-Effectiveness and Guidelines

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

103. Patient-Driven Analgesic Protocol Selection for Post-Cesarean Pain Management

(Clinical Trial) Actual Enrollment : 160 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Triple (Participant, Investigator, Outcomes Assessor) Primary Purpose: Treatment Official Title: Patient-Driven Analgesic Protocol Selection for Post-Cesarean Pain Management Actual Study Start Date : November 2015 Actual Primary Completion Date : May 22, 2017 Actual Study Completion Date : May 22, 2017 Resource links provided by the National Library of Medicine related topics (...) Patient-Driven Analgesic Protocol Selection for Post-Cesarean Pain Management Patient-Driven Analgesic Protocol Selection for Post-Cesarean Pain Management - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2015 Clinical Trials

104. Pain Management in Osteoarthritis Using the Centrally Acting Analgesics Duloxetine and Pregabalin

: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Treatment Official Title: Pain Management in Osteoarthritis Using the Centrally Acting Analgesics Duloxetine and Pregabalin Study Start Date : September 2013 Actual Primary Completion Date : May 2016 Actual Study Completion Date : July 2016 Resource links provided by the National Library of Medicine related topics: related topics: available for: Arms (...) Pain Management in Osteoarthritis Using the Centrally Acting Analgesics Duloxetine and Pregabalin Pain Management in Osteoarthritis Using the Centrally Acting Analgesics Duloxetine and Pregabalin - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove

2015 Clinical Trials

105. Nonpharmacologic pain interventions: a review of evidence-based practices for reducing chronic cancer pain.

the "Availability of Companion Documents" field). None provided Chronic cancer pain Management Treatment Nursing Oncology Advanced Practice Nurses Health Care Providers Nurses To critically appraise the strength and quality of the empirical evidence for nonpharmacologic interventions in reducing chronic cancer pain Patients with chronic cancer pain Celiac plexus block Radiation therapy Psychoeducational interventions Note : The following were considered, but their effectiveness is not established: dance (...) -acting or sustained or extended-release opioids (Only studies involving new formulations or unusual use of these medications will be included.) Studies involving examination of effects of different types of surgical anesthesia Studies involving surgical procedures as the primary intervention After removal of duplicates and studies that did not meet the inclusion criteria, the current authors found 154 studies that addressed nonpharmacologic interventions for chronic cancer pain management. Expert

2017 National Guideline Clearinghouse (partial archive)

106. Ischemic Pain Control With Analgesic Methods Clinical Trial

Ischemic Pain Control With Analgesic Methods Clinical Trial Ischemic Pain Control With Analgesic Methods Clinical Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Ischemic Pain Control With Analgesic (...) and qualitative control of ischemic pain in the lower limbs in patients with peripheral arterial occlusive disease through continuous sciatic nerve block by perineural catheter, popliteal approach, compared to systemic analgesia based on opioids. Condition or disease Intervention/treatment Phase Arterial Occlusive Diseases Procedure: Continuous peripheral sciatic nerve block Drug: Fentanyl Drug: Ropivacaine Device: Perineural catheter Phase 3 Detailed Description: BACKGROUND: Peripheral arterial occlusive

2016 Clinical Trials

107. A qualitative systematic review of head-to-head randomized controlled trials of oral analgesics in neuropathic pain

controlled trials of oral analgesics in neuropathic pain. Pain Research and Management 2010; 15(3): 147-157 PubMedID Original Paper URL Other URL Indexing Status Subject indexing assigned by NLM MeSH Administration, Oral; Analgesics /administration & Case-Control Studies; Databases, Factual /statistics & Humans; Neuralgia /drug therapy; Prevalence; Randomized Controlled Trials as Topic; dosage; numerical data AccessionNumber 12010005301 Date bibliographic record published 01/12/2010 Date abstract record (...) for inclusion. Only trials with a Jadad quality score of at least 3 were included. Trials that compared topical agents, intravenous studies, trials of acute neuropathic pain conditions, neuropathic pain with cancer and neuropathic pain conditions of trigeminal neuralgia and complex regional pain syndrome were excluded. The main outcome was pain relief. Other relevant outcomes were quality of life and vitality scores. Sixty-three per cent of trials compared different types of analgesics, sometimes

2010 DARE.

108. Analgesic Efficacy of Trans-muscular Quadratus Lumborum Block After Unilateral Inguinal Hernia Repair

Intervention Model: Parallel Assignment Masking: Double (Care Provider, Outcomes Assessor) Primary Purpose: Treatment Official Title: Quadratus Lumborum Block for Postoperative Pain Control in Patients Undergoing Unilateral Inguinal Hernia Repair, a Comparative Study Between Two Approaches Actual Study Start Date : June 1, 2018 Actual Primary Completion Date : September 1, 2018 Actual Study Completion Date : December 1, 2018 Resource links provided by the National Library of Medicine related topics: Arms (...) . This study was designed to compare the duration of analgesia provided by the original QLB and transmuscular QLB in patients undergoing surgical repair of unilateral inguinal hernia. Condition or disease Intervention/treatment Phase Postoperative Pain Ultrasound Guided Nerve Block Other: ultrasound guided quadratus lumborum block Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 40 participants Allocation: Randomized

2018 Clinical Trials

109. Minimizing Narcotic Analgesics After Endocrine Surgery

addiction pain management analgesia Additional relevant MeSH terms: Layout table for MeSH terms Thyroid Diseases Hyperplasia Thyroid Neoplasms Adenoma Thyroid Nodule Parathyroid Diseases Parathyroid Neoplasms Goiter Endocrine System Diseases Pathologic Processes Endocrine Gland Neoplasms Neoplasms by Site Neoplasms Head and Neck Neoplasms Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Acetaminophen Analgesics Tramadol Codeine Narcotics Analgesics, Non-Narcotic Sensory System Agents (...) or Parathyroid Surgery Actual Study Start Date : March 9, 2018 Estimated Primary Completion Date : June 2019 Estimated Study Completion Date : September 2019 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Acetaminophen Tylenol (also known as acetaminophen) 1000mg every 6 hours for 3 days and tramadol 50 mg every 6 hours as needed for moderate to severe pain Drug: Acetaminophen 500Mg Cap non

2018 Clinical Trials

110. MAST Trial: Multi-modal Analgesic Strategies in Trauma

Harvin, The University of Texas Health Science Center, Houston Study Details Study Description Go to Brief Summary: This is a comparative effectiveness study of current pain management strategies in acutely injured trauma patients. Two different multi-modal, opioid minimizing analgesic strategies will be compared. Condition or disease Intervention/treatment Phase Nonspecific Pain Post Traumatic Injury Drug: Acetaminophen IV/PO Drug: Acetaminophen PO Drug: Ketorolac Drug: Celebrex Drug: Naproxen Drug (...) MAST Trial: Multi-modal Analgesic Strategies in Trauma MAST Trial: Multi-modal Analgesic Strategies in Trauma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. MAST Trial: Multi-modal Analgesic Strategies

2018 Clinical Trials

111. Pre-emptive Analgesics in Orthodontic Treatment

analysis was completed. Primary Purpose: Treatment Official Title: Effects of Pre-emptive Use of Combined Ibuprofen and Acetaminophen on Pain Control in Orthodontic Treatment Actual Study Start Date : May 2, 2017 Actual Primary Completion Date : June 23, 2017 Actual Study Completion Date : August 1, 2017 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Acetaminophen Acetaminophen 650mg (...) using a numerical (0-10) visual analog scale (VAS) during rest, light biting, and while chewing paraffin wax during the following time intervals: immediately following drug administration, 6 hours after, the morning after, and the second morning after orthodontic treatment. Condition or disease Intervention/treatment Phase NSAID Pain Management Drug: Acetaminophen Drug: Ibuprofen Phase 4 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual

2018 Clinical Trials

112. Comparing Analgesic Efficacy of Systemic Lidocaine Against Placebo in General Anesthesia in Bariatric Surgery

into a "Lidocaine group" and a "Control group". The primary outcome will be the proportion of patients suffering from higher pain intensity within the first four hours after bariatric surgery. Secondary outcomes include the average maximal pain intensity during first four hours and during 48 hours, total opiate consumption, occurence of postoperative nausea and vomiting, time to first defecation and total time spent in hospital. Condition or disease Intervention/treatment Phase Pain, Postoperative Drug (...) : Lidocaine Hydrochloride Drug: Saline Solution Phase 3 Detailed Description: Postoperative pain is a common problem in today`s surgery, although pain management techniques have improved in the last years. Systemic application of lidocaine has gained interest since several studies have shown its analgesic, anti-inflammatory and antihyperalgesic properties. In this clinical trial the analgesic effect of intravenously administrated lidocaine is compared with placebo. Despite longstanding use

2018 Clinical Trials

113. Predictors for Analgesic Effect to Standardized Exercise Therapy for Osteoarthritic Pain

Predictors for Analgesic Effect to Standardized Exercise Therapy for Osteoarthritic Pain Predictors for Analgesic Effect to Standardized Exercise Therapy for Osteoarthritic Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) GLA:D®-træningsforløb Hos Patienter Med Symptomgivende Slidgigt i knæene Actual Study Start Date : October 1, 2017 Estimated Primary Completion Date : March 31, 2019 Estimated Study Completion Date : September 1, 2019 Resource links provided by the National Library of Medicine related topics: related topics: Groups and Cohorts Go to Group/Cohort Intervention/treatment Knee OA patients (part 1) Painful knee OA patients signed up for standardized exercise therapy Other: Physiotherapy-guided Evidence

2018 Clinical Trials

114. Prescription opioid analgesic use in France: trends and impact on morbidity-mortality. Full Text available with Trip Pro

Prescription opioid analgesic use in France: trends and impact on morbidity-mortality. While data from USA and Canada demonstrate an opioid overdose epidemic, very little nation-wide European studies have been published on this topical subject.Using a nationally representative sample of the French Claims database (>700,000 patients), the exhaustive nationwide hospital discharge database, and national mortality registry, all patients dispensed at least one prescription opioid (PO) in 2004-2017 (...) were identified, to describe trends in PO analgesic use, shopping behaviour, opioid-related hospitalizations and deaths. Annual prevalence of PO use and shopping behaviour (≥1 day of overlapping prescriptions from ≥2 prescribers, dispensed by ≥3 pharmacies) was estimated.In 2004-2017, the annual prevalence of weak opioid use codeine, tramadol and opium rose by 150%, 123%, and 244%, respectively (p < 0.05). Strong opioid use increased from 0.54% to 1.1% (+104%, p < 0.05), significantly for oxycodone

2018 European Journal of Pain

115. Preemptive Analgesic Effects of Popliteal Sciatic Nerve Block in Patients With Bilateral Hallux Valgus Surgery

Preemptive Analgesic Effects of Popliteal Sciatic Nerve Block in Patients With Bilateral Hallux Valgus Surgery Preemptive Analgesic Effects of Popliteal Sciatic Nerve Block in Patients With Bilateral Hallux Valgus Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) the operation of one leg is completed, PSNB is performed on both legs with 0.2% Ropivacaine and surgery is started on the remaining legs. When the surgery is over, check to see which foot pain begins first, how strong the pain is, and whether there are any side effects. Condition or disease Intervention/treatment Phase Pain, Postoperative Preemptive Peripheral Nerve Block Acute Pain Drug: Ultrasound guided popliteal sciatic nerve block with 0.2% ropivcaine Not Applicable Study Design Go to Layout table

2018 Clinical Trials

116. Postoperative Analgesic Efficacy of Continuous Wound Infusion After Laparoscopy

with placebo in patients undergoing benign gynecologic laparoscopy. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 66 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Triple (Participant, Investigator, Outcomes Assessor) Primary Purpose: Treatment Official Title: Postoperative Analgesic Efficacy of Continuous Wound Infusion After Laparoscopy (PAIN): a Randomized, Double-blind, Placebo-controlled (...) wound postoperatively has been widely used to reduce pain after cesarean section and open surgery. Studies evaluating the effectiveness of CWI to manage postoperative pain following laparoscopy are markedly lacking. Especially, there was no study comparing CWI and placebo in treating gynecologic laparoscopy. Therefore, the investigators conducted this randomized, double-blind, placebo-controlled trial to investigate whether CWI of local anesthetics was an effective strategy for ERAS, compared

2018 Clinical Trials

117. Add-on Buprenorphine at Analgesic Doses for the Treatment of Severe Suicidal Ideas During a Major Depressive Episode

Add-on Buprenorphine at Analgesic Doses for the Treatment of Severe Suicidal Ideas During a Major Depressive Episode Add-on Buprenorphine at Analgesic Doses for the Treatment of Severe Suicidal Ideas During a Major Depressive Episode - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 180 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Participant, Investigator) Primary Purpose: Treatment Official Title: Add-on Buprenorphine at Analgesic Doses for the Treatment of Severe Suicidal Ideas During a Major Depressive Episode Estimated Study Start Date : September 2019 Estimated Primary Completion Date : September 2020 Estimated

2018 Clinical Trials

118. A Comparison of the Post-C/S Analgesic Effects of Neuraxial Duramorph vs Bilateral TAP Block With Liposomal Bupivacaine

or intrathecal Duramorph, a TAP block with liposomal bupivacaine (Exparel) will provide better, longer-acting pain control and will significantly reduce the use of post-operative IV or p.o. opiates. This is a prospective, randomized clinical trial. Condition or disease Intervention/treatment Phase Caesarean Section Drug: Exparel Phase 4 Detailed Description: The investigators will compare the analgesic efficacy and duration of an ultrasound guided bilateral TAP Block (with combined bupivacaine and liposomal (...) bupivacaine) to Duramorph (an opiate). Neuraxial duramorph provides approximately 24 hours of pain relief (analgesia), whereas a bilateral TAP block with liposomal bupivacaine is expected to provide up to 72 hours of analgesia. All participants will have neuraxial anesthesia (either a spinal or epidural) for their non-urgent or elective Cesarean section. The control group (Group 1) will receive either intrathecal or epidural Duramorph (preservative-free morphine sulfate). Post-operatively, participants

2018 Clinical Trials

119. Evaluation of the Effects of Different Analgesics on Pericoronitis Pain and Quality of Life

Evaluation of the Effects of Different Analgesics on Pericoronitis Pain and Quality of Life Evaluation of the Effects of Different Analgesics on Pericoronitis Pain and Quality of Life - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Evaluation of the Effects of Different Analgesics on Pericoronitis Pain and Quality of Life The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03745599 Recruitment Status : Completed First Posted : November 19, 2018 Last Update Posted : November 19, 2018 Sponsor: Near East

2018 Clinical Trials

120. Comparison of Analgesic Efficiency Between IPACK Block and Surgical Infiltration After Total Knee Arthroplasty

infiltration after total knee arthroplasty. The main objective is to compare cumulative morphine consumption the first 24 hours after surgery. The secondary objectives are to compare pain scores, types and amounts of other analgesics needed during the first 24 hours after surgery. Condition or disease Intervention/treatment Total Knee Arthroplasty Other: Injection of local anesthetics during total knee arthroplasty by a locoregional anesthesia named IPACK block Other: Injection of local anesthetics during (...) Comparison of Analgesic Efficiency Between IPACK Block and Surgical Infiltration After Total Knee Arthroplasty Comparison of Analgesic Efficiency Between IPACK Block and Surgical Infiltration After Total Knee Arthroplasty - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2018 Clinical Trials

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