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Topical Analgesic

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101. Comparing Analgesic Efficacy of Systemic Lidocaine Against Placebo in General Anesthesia in Bariatric Surgery

Comparing Analgesic Efficacy of Systemic Lidocaine Against Placebo in General Anesthesia in Bariatric Surgery Comparing Analgesic Efficacy of Systemic Lidocaine Against Placebo in General Anesthesia in Bariatric Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Comparing Analgesic Efficacy of Systemic Lidocaine Against Placebo in General Anesthesia in Bariatric Surgery (COALAS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov

2018 Clinical Trials

102. Pre-emptive Analgesics in Orthodontic Treatment

Pre-emptive Analgesics in Orthodontic Treatment Pre-emptive Analgesics in Orthodontic Treatment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Pre-emptive Analgesics in Orthodontic Treatment The safety (...) analysis was completed. Primary Purpose: Treatment Official Title: Effects of Pre-emptive Use of Combined Ibuprofen and Acetaminophen on Pain Control in Orthodontic Treatment Actual Study Start Date : May 2, 2017 Actual Primary Completion Date : June 23, 2017 Actual Study Completion Date : August 1, 2017 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Acetaminophen Acetaminophen 650mg

2018 Clinical Trials

103. Post-Operative Analgesic Effects of Local Wound Infiltration With Ketorolac After Inguinal Herniorrhaphy

Post-Operative Analgesic Effects of Local Wound Infiltration With Ketorolac After Inguinal Herniorrhaphy Post-Operative Analgesic Effects of Local Wound Infiltration With Ketorolac After Inguinal Herniorrhaphy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Post-Operative Analgesic Effects of Local Wound Infiltration With Ketorolac After Inguinal Herniorrhaphy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03534505

2018 Clinical Trials

104. Efficacy and Analgesic Use During the Therapy of Iatrogenic Pneumothorax Using Pleuralventâ„¢ and Chest Tube

) Masking Description: Method of closed envelopes Primary Purpose: Treatment Official Title: ASPIRATE Study- Comparison of Efficacy and Analgesic Use During the Therapy of Iatrogenic Pneumothorax Using Pleuralvent™ and Large Bore Chest Tube (16F) Actual Study Start Date : February 3, 2019 Estimated Primary Completion Date : November 1, 2022 Estimated Study Completion Date : November 1, 2022 Resource links provided by the National Library of Medicine related topics: related topics: Arms and Interventions (...) Efficacy and Analgesic Use During the Therapy of Iatrogenic Pneumothorax Using Pleuralventâ„¢ and Chest Tube Efficacy and Analgesic Use During the Therapy of Iatrogenic Pneumothorax Using Pleuralvent™ and Chest Tube - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2018 Clinical Trials

105. Analgesic Efficacy of Pulsed Radiofrequency in Non-cyclic Mastalgia

Type : Interventional (Clinical Trial) Actual Enrollment : 64 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Analgesic Efficacy of Pulsed Radiofrequency in Non-cyclic Mastalgia Actual Study Start Date : August 15, 2018 Actual Primary Completion Date : December 1, 2018 Actual Study Completion Date : December 1, 2018 Resource links provided by the National Library of Medicine related topics: available (...) Analgesic Efficacy of Pulsed Radiofrequency in Non-cyclic Mastalgia Analgesic Efficacy of Pulsed Radiofrequency in Non-cyclic Mastalgia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Analgesic Efficacy

2018 Clinical Trials

106. Pain Comparison Whit Visual Analog Scale (EVA) Between Four Analgesic Methods During Trans Rectal Prostatic Biopsy

22, 2018 Last Update Posted : March 27, 2018 Sponsor: Instituto Mexicano del Seguro Social Information provided by (Responsible Party): EDGAR BELTRAN-SUAREZ, Instituto Mexicano del Seguro Social Study Details Study Description Go to Brief Summary: Define the best analgesic method between peri prostatic blockage, analgesic suppository, oral analgesic and topic anesthetic gel, during trans rectal prostate biopsy Condition or disease Cancer of Prostate Detailed Description: Comparison between four (...) Library of Medicine related topics: related topics: Groups and Cohorts Go to Group/Cohort Group 1 Group 1 an analgesic suppository was applied Group 2 Group 2 was administered analgesic orally Group 3 Group 3 was given trans rectal gel Group 4 Group was performed peri prostatic infiltration. Group 5 Group was performed by placebo oral Outcome Measures Go to Primary Outcome Measures : Ultrasound Transducer [ Time Frame: Interview 15 to 30 minutes at the end of the procedure ] Evaluation

2018 Clinical Trials

107. Comparison of Analgesic Efficiency Between IPACK Block and Surgical Infiltration After Total Knee Arthroplasty

Comparison of Analgesic Efficiency Between IPACK Block and Surgical Infiltration After Total Knee Arthroplasty Comparison of Analgesic Efficiency Between IPACK Block and Surgical Infiltration After Total Knee Arthroplasty - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Comparison of Analgesic Efficiency Between IPACK Block and Surgical Infiltration After Total Knee Arthroplasty (IPACK) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov

2018 Clinical Trials

108. Prescription opioid analgesic use in France: trends and impact on morbidity-mortality. (PubMed)

Prescription opioid analgesic use in France: trends and impact on morbidity-mortality. While data from USA and Canada demonstrate an opioid overdose epidemic, very little nation-wide European studies have been published on this topical subject.Using a nationally representative sample of the French Claims database (>700,000 patients), the exhaustive nationwide hospital discharge database, and national mortality registry, all patients dispensed at least one prescription opioid (PO) in 2004-2017 (...) were identified, to describe trends in PO analgesic use, shopping behaviour, opioid-related hospitalizations and deaths. Annual prevalence of PO use and shopping behaviour (≥1 day of overlapping prescriptions from ≥2 prescribers, dispensed by ≥3 pharmacies) was estimated.In 2004-2017, the annual prevalence of weak opioid use codeine, tramadol and opium rose by 150%, 123%, and 244%, respectively (p < 0.05). Strong opioid use increased from 0.54% to 1.1% (+104%, p < 0.05), significantly for oxycodone

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2018 European Journal of Pain

109. Randomized controlled trial to compare oral analgesic requirements and patient satisfaction in using oral non-steroidal anti-inflammatory drugs versus benzydamine hydrochloride oral rinses after mandibular third molar extraction: a pilot study (PubMed)

Randomized controlled trial to compare oral analgesic requirements and patient satisfaction in using oral non-steroidal anti-inflammatory drugs versus benzydamine hydrochloride oral rinses after mandibular third molar extraction: a pilot study Third molar extraction is associated with considerable pain and discomfort, which is mostly managed with oral analgesic medication. We assessed the analgesic effect of benzydamine hydrochloride, a topical analgesic oral rinse, for controlling (...) postoperative pain following third molar extraction.A randomized controlled trial was conducted in 40 patients divided into two groups, for extraction of fully erupted third molar. Groups A received benzydamine hydrochloride mouthwash and group B received normal saline gargle with oral ibuprofen and paracetamol. Oral ibuprofen and paracetamol was the rescue analgesic drug in group A. Patients were evaluated on the 3rd and 7th post-operative days (POD) for pain using the visual analogue score (VAS), trismus

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2018 Journal of Dental Anesthesia and Pain Medicine

110. Predictors for Analgesic Effect to Standardized Exercise Therapy for Osteoarthritic Pain

Predictors for Analgesic Effect to Standardized Exercise Therapy for Osteoarthritic Pain Predictors for Analgesic Effect to Standardized Exercise Therapy for Osteoarthritic Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Predictors for Analgesic Effect to Standardized Exercise Therapy for Osteoarthritic Pain The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03718663 Recruitment Status : Recruiting First Posted : October

2018 Clinical Trials

111. Effect of Topical Baclofen 5% on Post-Hemorrhoidectomy Pain: Randomized Double Blind Placebo-Controlled Clinical Trial. (PubMed)

Effect of Topical Baclofen 5% on Post-Hemorrhoidectomy Pain: Randomized Double Blind Placebo-Controlled Clinical Trial. Baclofen is an agonist for a subtype of gamma-amino butyric acid (GABA-B) receptors and traditionally been used for the systemic treatment of spasticity. Topical application of baclofen has been shown to reduce pain in patients with localized neuropathic pain.In this study, we investigate the efficacy of baclofen cream (5%) in reducing postoperative pain and analgesic (...) requirement after open hemorrhoidectomy.The patients were randomly assigned to either baclofen (5%) cream or placebo immediately after surgery and then every 12 h for 14 days.A total of 66 patients with third- and fourth-degree hemorrhoids undergoing open hemorrhoidectomy were randomly assigned to this trial.This study was conducted at a single educational hospital.The primary outcomes were intensity of pain, measured with a visual analog scale, and the analgesic requirement, measured by the amount

2019 Journal of Gastrointestinal Surgery

112. Topical morphine for treatment of cancer-related painful mucosal and cutaneous lesions: a double-blind, placebo-controlled cross-over clinical trial. (PubMed)

Topical morphine for treatment of cancer-related painful mucosal and cutaneous lesions: a double-blind, placebo-controlled cross-over clinical trial. Painful mucosal and cutaneous lesions are often less responsive or even refractory to systemic opioid analgesics. There is evidence suggesting that the effectiveness of topical morphine be restricted to inflammatory pain. The studied groups were small and the observation period relatively short. The aim of this study was to assess (...) the effectiveness and safety of topical morphine for pain related to mucosal lesions and skin ulcers.The study was a 14-day randomized placebo-controlled cross-over trial (RCT) with a 28-day follow-up open phase (OP). The trial was conducted in adult patients with localized cancer-related pain and treated with systemic opioids in an oncology center or home hospice. The patients administered 0.2% gel on the mucosal lesion or 0.2% ointment on the skin lesion by themselves, without restrictions regarding

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2019 Archives of medical science : AMS

113. Hot topics in opioid pharmacology: mixed and biased opioids. (PubMed)

Hot topics in opioid pharmacology: mixed and biased opioids. Analgesic design and evaluation have been driven by the desire to create high-affinity high-selectivity mu (μ)-opioid peptide (MOP) receptor agonists. Such ligands are the mainstay of current clinical practice, and include morphine and fentanyl. Advances in this sphere have come from designing pharmacokinetic advantage, as in rapid metabolism for remifentanil. These produce analgesia, but also the adverse-effect profile that currently (...) . There is sufficient excitement in the opioid field to suggest that opioid analgesics without significant side-effects may be on the horizon, and the 'opioid Holy Grail' might be in reach.Copyright © 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

2019 British Journal of Anaesthesia

114. Topical Lidocaine Patch for Postthoracotomy and Poststernotomy Pain in Cardiothoracic Intensive Care Unit Adult Patients. (PubMed)

Topical Lidocaine Patch for Postthoracotomy and Poststernotomy Pain in Cardiothoracic Intensive Care Unit Adult Patients. Transdermal lidocaine patches have few systemic toxicities and may be useful analgesics in cardiac surgery patients. However, few studies have evaluated their efficacy in the perioperative setting. Objective To compare the efficacy of topical lidocaine 5% patch plus standard care (opioid and nonopioid analgesics) with standard care alone for postthoracotomy or poststernotomy (...) pain in adult patients in a cardiothoracic intensive care unit.A single-center, retrospective cohort evaluation was conducted from January 2015 through December 2015 in the adult cardiothoracic intensive care unit at a tertiary academic medical center. Cardiac surgery patients with new sternotomies or thoracotomies were included. Patients in the lidocaine group received 1 to 3 topical lidocaine 5% patches near sternotomy and/or thoracotomy sites daily. Patches remained in place for 12 hours daily

2019 Critical care nurse

115. Oral opioid analgesics vs spinal steroid injections in the treatment of low back pain syndromes

Oral opioid analgesics vs spinal steroid injections in the treatment of low back pain syndromes Oral opioid analgesics vs spinal steroid injections in the treatment of low back pain syndromes Oral opioid analgesics vs spinal steroid injections in the treatment of low back pain syndromes Nampiaparampil DE, Nampiaparampil GM, Nampiaparampil RG CRD summary This review found that opioid therapy and percutaneous spinal steroid injections were both helpful for low back pain and disability but high (...) drop-out rates precluded conclusions about opioid therapy for chronic low back pain. The cautious conclusion reflects problems with the evidence but its reliability is limited by a lack of detail on review methods and study quality. Authors' objectives To evaluate outcomes and adverse effects of oral opioid analgesics and spinal steroid injections in the treatment of low back pain syndromes. Searching Ten databases including MEDLINE, EMBASE and clinical trials registries were searched without

2012 DARE.

116. Pain and supplemental analgesic requirements with different basic analgesic regimens after total hip or knee arthroplasty: a topical review

Pain and supplemental analgesic requirements with different basic analgesic regimens after total hip or knee arthroplasty: a topical review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne (...) . Not about analgesics used in the clinic Full text-screening: As above, with the addition of: 7. No relevant outcome measure reported ">Prioritise the exclusion criteria Example: Two reviewers will independently extract data from each article. We first try to extract numerical data from tables, text or figures. If these are not reported, we will extract data from graphs using digital ruler software. In case data are not reported or unclear, we will attempt to contact authors by e-mail (max. 2 attempts

2016 PROSPERO

117. Analgesic efficacy of intravenous naloxone for the treatment of postoperative pruritus: a meta-analysis

Analgesic efficacy of intravenous naloxone for the treatment of postoperative pruritus: a meta-analysis Analgesic efficacy of intravenous naloxone for the treatment of postoperative pruritus: a meta-analysis Analgesic efficacy of intravenous naloxone for the treatment of postoperative pruritus: a meta-analysis Murphy JD, Gelfand HJ, Bicket MC, Ouanes JP, Kumar KK, Isaac GR, Wu CL CRD summary This review concluded that intravenous naloxone was associated with decreased postoperative pruritis (...) and nausea, without increasing pain scores. No significant differences were found between naloxone and control groups for opioid consumption, or risk of sedation or emesis. These conclusions reflect the evidence, but methodological limitations of the review and its evidence base suggest that they may not be reliable. Authors' objectives To evaluate the analgesic efficacy of intravenous naloxone for treatment of postoperative pruritis. Searching PubMed and EMBASE were searched with no language

2011 DARE.

118. Intraoperative Low-dose Ketamine Infusion as the Main Analgesic in Burn Patients

: Treatment Official Title: Intraoperative Low-dose Ketamine Infusion as the Main Analgesic in Burn Patients Actual Study Start Date : February 27, 2018 Estimated Primary Completion Date : August 2020 Estimated Study Completion Date : August 2020 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Ketamine Participants randomized to this arm will receive ketamine (1 mg/ml solution) infused at 0.2 (...) Intraoperative Low-dose Ketamine Infusion as the Main Analgesic in Burn Patients Intraoperative Low-dose Ketamine Infusion as the Main Analgesic in Burn Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2017 Clinical Trials

119. A Study to Evaluate the Analgesic Efficacy and Safety of V120083 in Subjects With Osteoarthritis (OA) of the Knee

and able to stop taking any/all analgesic medications, including over-the-counter pain medications, opioids, marijuana, and topical analgesics for OA pain for the duration of the study, with the exception of study-specific rescue medication. Key Exclusion Criteria Include: Subjects with radiographic evidence of OA with K-L grade 0,1 or 4 Subjects with chronic pain conditions other than OA of the knee as their predominant pain condition, including gout, pseudogout, psoriatic arthritis, active Lyme (...) A Study to Evaluate the Analgesic Efficacy and Safety of V120083 in Subjects With Osteoarthritis (OA) of the Knee A Study to Evaluate the Analgesic Efficacy and Safety of V120083 in Subjects With Osteoarthritis (OA) of the Knee - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2017 Clinical Trials

120. Efficacy of Pethidine, Ketorolac And Xylocaine Gel As Analgesics For Pain Control In Shockwave Lithotripsy

Efficacy of Pethidine, Ketorolac And Xylocaine Gel As Analgesics For Pain Control In Shockwave Lithotripsy Efficacy of Pethidine, Ketorolac And Xylocaine Gel As Analgesics For Pain Control In Shockwave Lithotripsy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Efficacy of Pethidine, Ketorolac And Xylocaine Gel As Analgesics For Pain Control In Shockwave Lithotripsy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03032458 Recruitment Status : Completed First Posted : January 26, 2017 Last Update Posted

2017 Clinical Trials

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