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Topical Analgesic

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81. Fenugreek dermal patch, a new natural topical antinociceptive medication for relieving the postherniotomy pain, a double-blind placebo controlled trial. (Abstract)

Fenugreek dermal patch, a new natural topical antinociceptive medication for relieving the postherniotomy pain, a double-blind placebo controlled trial. Background Fenugreek seeds have shown antinociceptive effect in animal studies. This double-blind placebo controlled trial was designed to study the effect of fenugreek transdermal patch 10% (FDP) for management of inguinal hernia (IH) post-operative pain. Methods Standardized extract of fenugreek seeds was used for FDP formulation. Ninety (...) suppository demand were significantly decreased in FDP group (p<0.05). Conclusion In all, results of the present study indicated that FDP decreases pain score and demand for morphine in post-surgery patients in comparison to diclofenac patch, and this preparation could be a suit option as a natural antinociceptive agent for pain management.

2019 Journal of complementary & integrative medicine Controlled trial quality: uncertain

82. Randomised controlled trial to investigate the effectiveness of thoracic epidural and paravertebral blockade in reducing chronic post-thoracotomy pain (TOPIC): a pilot study to assess feasibility of a large multicentre trial. Full Text available with Trip Pro

Randomised controlled trial to investigate the effectiveness of thoracic epidural and paravertebral blockade in reducing chronic post-thoracotomy pain (TOPIC): a pilot study to assess feasibility of a large multicentre trial. Thoracotomy is considered one of the most painful surgical procedures. The incidence of chronic post-thoracotomy pain (CPTP) is up to 50%. Paravertebral blockade (PVB) may be superior to thoracic epidural blockade (TEB) in preventing CPTP. The specific objective (...) booklets at 6 months. The number of participants indicating at least a moderate level of chest pain at 6 months was lower with PVB but with high levels of uncertainty (RR: 0.7; 95% CI 0.3 to 1.7 for worst pain; RR: 0.3; 95% CI 0.0 to 2.8 for average pain). There were no safety concerns.A large, multicentre randomised controlled trial of PVB versus TEB is feasible as it is possible to randomise and follow up participants with high fidelity. Pain scores were lower on average with PVB compared with TEB

2019 BMJ open Controlled trial quality: predicted high

83. Efficacy of Topical Vibratory Stimulation for Reducing Pain During Trigger Point Injection to the Gastrocnemius: A Randomized Controlled Trial. (Abstract)

Efficacy of Topical Vibratory Stimulation for Reducing Pain During Trigger Point Injection to the Gastrocnemius: A Randomized Controlled Trial. To evaluate the efficacy of topical vibratory stimulation for reducing pain during trigger point injection (TPI).Double-blind randomized placebo-controlled clinical trial.Tertiary care university hospital.A total of 136 participants were randomly recruited from among patients with myofascial pain syndrome who were scheduled for TPI. Of these, 65 were (...) for the control group.Pain intensity during TPI was assessed using a 100-mm visual analog scale (VAS) as a primary outcome, and participant satisfaction and preference for repeated use were measured using 5-point Likert scales as a secondary outcome. These parameters were evaluated immediately after TPI. The primary outcome was evaluated using analysis of covariance and secondary outcome using the Mann-Whitney U test.VAS scores for pain during TPI were significantly lower in the vibration group (30.30; 95

2019 Archives of physical medicine and rehabilitation Controlled trial quality: predicted high

84. Effect of Topical Baclofen 5% on Post-Hemorrhoidectomy Pain: Randomized Double Blind Placebo-Controlled Clinical Trial. (Abstract)

Effect of Topical Baclofen 5% on Post-Hemorrhoidectomy Pain: Randomized Double Blind Placebo-Controlled Clinical Trial. Baclofen is an agonist for a subtype of gamma-amino butyric acid (GABA-B) receptors and traditionally been used for the systemic treatment of spasticity. Topical application of baclofen has been shown to reduce pain in patients with localized neuropathic pain.In this study, we investigate the efficacy of baclofen cream (5%) in reducing postoperative pain and analgesic (...) of the acetaminophen consumption.No significant difference was found in baseline characteristics between the two groups. Postoperative pain score of the baclofen group was significantly lower on week 1 (P = 0.01) and week 2 (P = 0.02) than the placebo group. Similarly, patients in the baclofen group consumed significantly less analgesic medication on week 1 (P = 0.025) and week 2 (P = 0.024) than the control group.Topical application of baclofen effectively relieves pain after hemorrhoidectomy with minimal side

2019 Journal of Gastrointestinal Surgery Controlled trial quality: predicted high

85. Topical morphine for treatment of cancer-related painful mucosal and cutaneous lesions: a double-blind, placebo-controlled cross-over clinical trial. Full Text available with Trip Pro

Topical morphine for treatment of cancer-related painful mucosal and cutaneous lesions: a double-blind, placebo-controlled cross-over clinical trial. Painful mucosal and cutaneous lesions are often less responsive or even refractory to systemic opioid analgesics. There is evidence suggesting that the effectiveness of topical morphine be restricted to inflammatory pain. The studied groups were small and the observation period relatively short. The aim of this study was to assess (...) the effectiveness and safety of topical morphine for pain related to mucosal lesions and skin ulcers.The study was a 14-day randomized placebo-controlled cross-over trial (RCT) with a 28-day follow-up open phase (OP). The trial was conducted in adult patients with localized cancer-related pain and treated with systemic opioids in an oncology center or home hospice. The patients administered 0.2% gel on the mucosal lesion or 0.2% ointment on the skin lesion by themselves, without restrictions regarding

2019 Archives of medical science : AMS Controlled trial quality: uncertain

86. Effects of topical sesame (Sesamum indicum) oil on the pain severity of chemotherapy-induced phlebitis in patients with colorectal cancer: A randomized controlled trial. (Abstract)

Effects of topical sesame (Sesamum indicum) oil on the pain severity of chemotherapy-induced phlebitis in patients with colorectal cancer: A randomized controlled trial. Chemotherapy-induced phlebitis (CIP) is one of the most important and common complications in patients with cancer. Currently, the use of complementary methods to prevent or alleviate phlebitis symptoms has attracted great attention. In this study, we aimed to assess the effects of topical sesame oil in reducing the pain (...) to the baseline were significant on the third (P = 0.009), fifth (P < 0.001), and seventh (P < 0.001) days of the intervention in favor of the experimental group. Also, a significant reduction in the pain severity both in the experimental and control groups was observed during the seven days (F = 720.66, Ptime < 0.001); however, the decrease was more significant in the experimental group (F = 21.46, Pgroup < 0.001).Application of massage with sesame oil as a complementary method is effective in reducing

2019 Complementary Therapies in Clinical Practice Controlled trial quality: uncertain

87. Consensus Practice Guidelines on Interventions for Lumbar Facet Joint Pain

facetogenic pain; ? Lack of information on important outcome measures. More information may allow estimation of effects on treatment outcomes. grading of evidence guidelines, with the level of certainty rated as high, medium or low (tables 1–3). 29 This system, which has been modified for use in interventional pain management guide- lines drafted by the American Society of Regional Anesthesia & Pain Medicine, American Academy of Pain Medicine, American Society of Anesthesiologists, American Society (...) Pain Med: first published as 10.1136/rapm-2019-101243 on 3 April 2020. Downloaded from 4 Cohen SP , et al. Reg Anesth Pain Med 2020;0:1–44. doi:10.1136/rapm-2019-101243 Special article Table 4 Studies evaluating physical examination findings and facet block results Study design/criteria for positive block Interventions findings Fairbank et al 37 Prospective n=25 Subjective pain relief IA (double blocks, one injection at symptomatic level, another at a random level) Responders: pain in the back

2020 American Academy of Pain Medicine

88. Consensus Practice Guidelines on Interventions for Lumbar Facet Joint Pain from a Multispecialty, International Working Group Full Text available with Trip Pro

Consensus Practice Guidelines on Interventions for Lumbar Facet Joint Pain from a Multispecialty, International Working Group Consensus practice guidelines on interventions for lumbar facet joint pain from a multispecialty, international working group | Regional Anesthesia & Pain Medicine Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search (...) for this keyword Main menu Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Consensus practice guidelines on interventions for lumbar facet joint pain from a multispecialty, international working group Article Text Special article Consensus practice guidelines on interventions for lumbar facet joint pain from a multispecialty, international working group Steven P Cohen

2020 American Society of Regional Anesthesia and Pain Medicine

89. Prospective randomized controlled trial comparing standard analgesia with combined intra-operative cystic plate and port-site local anesthesia for post-operative pain management in elective laparoscopic cholecystectomy. (Abstract)

Prospective randomized controlled trial comparing standard analgesia with combined intra-operative cystic plate and port-site local anesthesia for post-operative pain management in elective laparoscopic cholecystectomy. Various mechanisms, including somatic and visceral nociceptive stimulation, have been suggested as a cause for pain after laparoscopic cholecystectomy (LC). We therefore conducted a prospective randomized controlled trial (PRCT) to evaluate whether somatovisceral pain blockade (...) -opioid/opioid analgesic combinations (Control Group, n = 32) and non-opioid/opioid analgesic combinations plus topical 0.25 % bupivacaine onto the cystic plate and local 0.25 % bupivacaine port-site injection, post-LC (Study Group, n = 31). Primary endpoint was patient-reported pain 1, 4, 6, 12, 24 h and 1 week post-LC using the Visual Analog Scale (VAS 0-10).Study groups were comparable clinicopathologically. There were no adverse events. A statistically significant reduction in mean pain score

2016 Surgical endoscopy Controlled trial quality: predicted high

90. A RCT of a Combination of Analgesics for Pain Management in Children With a Suspected Fracture

Study Type : Interventional (Clinical Trial) Estimated Enrollment : 300 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Triple (Participant, Care Provider, Investigator) Primary Purpose: Treatment Official Title: A Randomized Controlled Trial of a Combination of Analgesics for Pain Management in Children With a Suspected Fracture at Triage (CAST Trial) Estimated Study Start Date : December 2019 Estimated Primary Completion Date : October 2020 Estimated Study (...) by providing a consistent and adequate level of analgesia throughout the entire ED visit, including prior to physician exam and during painful radiologic procedures. Condition or disease Intervention/treatment Phase Emergency Service, Hospital Child/Adolescent Problem Acute Pain Fentanyl Ibuprofen Analgesics, Opioid Anti-inflammatory Agents, Non-steroidal Drug: Fentanyl intranasal + Oral Hydromorphone Drug: Fentanyl intranasal + Oral ibuprofen Phase 4 Study Design Go to Layout table for study information

2016 Clinical Trials

91. Effect of Topical Lidocaine Patch on Postoperative Pain Management in Laparoscopic Appendectomy: A Randomized, Double-Blind, Prospective Study. (Abstract)

Effect of Topical Lidocaine Patch on Postoperative Pain Management in Laparoscopic Appendectomy: A Randomized, Double-Blind, Prospective Study. Adequate pain control is a major concern in the immediate postoperative period. In multiple strategies for postoperative pain management, topical analgesics have significant advantages of minimizing severe side effects caused by oral and parenteral administration and drug-drug interactions. Therefore, we studied the effect of lidocaine patch (...) in the control group (0.10 ± 0.31 mg versus 0.25 ± 0.79 mg, P < .001).The results of this study suggest that lidocaine patch application to the trocar site after laparoscopic appendectomy may have a positive effect on the management of postoperative pain and can eliminate the need to inject additional analgesics for further postoperative pain control.

2018 Journal of laparoendoscopic & advanced surgical techniques. Part A Controlled trial quality: uncertain

92. High-concentration topical capsaicin in the management of refractory neuropathic pain in patients with Neurofibromatosis type 1: a case series. (Abstract)

High-concentration topical capsaicin in the management of refractory neuropathic pain in patients with Neurofibromatosis type 1: a case series. The aim of this case series was to report the use of 8% topical capsaicin patch (marketed under the trade name Qutenza®) a in the management of refractory neuropathic pain (NP) in adult patients with type 1 neurofibromatosis (NF1).Capsaicin has been suggested for NF1 patients suffering from refractory peripheral NP despite several years of analgesic (...) treatments. The patch was applied for 60 minutes on the painful area, with tolerability control (blood pressure, intensity of pain and dermal reaction). The evaluation was done at the beginning of treatment and during the 2 months following the first treatment (phone calls at weeks 1, 2, 4 and 8). The primary efficacy criterion was the response rate: a patient was considered to be responding if he or she reported an average relief ≥30% at the time of the follow-up calls. The secondary criteria were

2018 Current medical research and opinion

93. The efficacy of topical cannabis for the management of pain: A systematic review

The efficacy of topical cannabis for the management of pain: A systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email (...) tumor 4. No control group 5. Combination therapy or contamination 6. Not about analgesics used in the clinic Full text-screening: As above, with the addition of: 7. No relevant outcome measure reported ">Prioritise the exclusion criteria Example: Two reviewers will independently extract data from each article. We first try to extract numerical data from tables, text or figures. If these are not reported, we will extract data from graphs using digital ruler software. In case data are not reported

2020 PROSPERO

94. Mechanical Low Back Pain: Secular Trend and Intervention Topics of Randomized Controlled Trials Full Text available with Trip Pro

Mechanical Low Back Pain: Secular Trend and Intervention Topics of Randomized Controlled Trials To evaluate the number of published randomized controlled trials (RCTs) focusing on mechanical low back pain (MLBP) rehabilitation, the secular (i.e., long-term) trend, and the distribution of interventions studied.All included RCTs were extracted from all Cochrane systematic reviews focusing on rehabilitation therapies for MLBP, and two independent reviewers screened and analyzed the information (...) on interventions.After removal of duplicates, the data set consisted of 196 RCTs published between 1961 and 2010. The number of RCTs published increased consistently over time: 2 trials (1% of the total) were published in 1961-1970, 10 (5%) in 1971-1980, 41 (21%) in 1981-1990, 68 (35%) in 1991-2000, and 75 (38%) in 2001-2010. The intervention of interest in the majority of RCTs was exercise therapy (115/399; 29%), followed by spinal manipulation therapies (60/399; 15%).The number of RCTs focusing on MLBP has risen

2016 Physiotherapy Canada

95. Antibiotic Use for the Urgent Management of Dental Pain and Intra-oral Swelling Clinical Practice Guideline Full Text available with Trip Pro

, A., Carrasco-Labra, A., and Mariotti, A. Benefits and harms associated with analgesic medications used in the management of acute dental pain: an overview of systematic reviews. JADA . 2018 ; 149 : 256–265 e3 | | | | | Localized acute apical abscess is characterized by spontaneous pain with or without mastication, percussion, or palpation, with formation of purulent material, localized swelling, and without evidence of fascial space or local lymph node involvement, fever, or malaise (fatigue, reduced (...) tablet less and 2 more rescue analgesic tablets than those who did not take antibiotics over 7 days (low certainty) ( eTable 3 , available online at the end of this article). x 40 Nagle, D., Reader, A., Beck, M., and Weaver, J. Effect of systemic penicillin on pain in untreated irreversible pulpitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod . 2000 ; 90 : 636–640 | | | | | We identified no randomized controlled trials meeting our selection criteria that reported undesirable effects

2020 American Dental Association Guidelines

96. Pain Management Best Practices from Multispecialty Organizations during the COVID-19 Pandemic and Public Health Crises

and Rehabilitation, Walter Reed National Military Medical Center, Uniformed Services University of the Health Sciences , Bethesda, MD Corresponding Author: Steven P. Cohen, M.D. Pain Medicine, Dept. of Anesthesiology and Critical Care Medicine, 550 N. Broadway, Suite 301, Baltimore, MD 21205. Tel: 410-955-7246; E-mail: Search for other works by this author on: , Zafeer B Baber, MD Division of Anesthesiology and Interventional Pain Management, Lahey Hospital & Medical Center , Beth Israel Lahey Health, Burlington (...) , conservation of resources, and access to pain management services. Specific issues discussed include general and interventional-specific risk mitigation, patient flow issues and staffing plans, telemedicine options, triaging recommendations, strategies to reduce psychological sequelae in health care providers, and resource utilization. Conclusions The COVID-19 public health crisis has strained health care systems, creating a conundrum for patients, pain medicine practitioners, hospital leaders

2020 American Academy of Pain Medicine

97. Is a clinically guided steroid injection as effective in terms of pain relief and improved function as an ultrasound guided injection for patient with first CMC joint osteoarthritis (OA)

injection as effective in terms of pain relief and improved function as an ultrasound guided injection for patient with first CMC joint osteoarthritis (OA) Clinical bottom line Only one small randomised controlled study answered our specific question. This evidence should be treated with caution as although it included 148 patients, only a small number had CMC OA (5% i.e. 7 patients). It suggests that a clinician guided injection is more effective in reducing pain compared to an ultrasound guided (...) Is a clinically guided steroid injection as effective in terms of pain relief and improved function as an ultrasound guided injection for patient with first CMC joint osteoarthritis (OA) Getting Evidence into Clinical Practice: Musculoskeletal Research Facilitation Group (CAT Group) Date: September 2016 CAT Lead: Kay Stevenson and Kirsty Thomson Date CAT completed: Email: kay.stevenson@uhns.nhs.uk Date CAT to be reviewed: September 2018 Specific Question: Is a clinically guided steroid

2016 Public Health England

98. Low back pain and radicular pain: evaluation and management

TREATMENT (MEDICATION EXCLUDED) 38 3.2.1 Self-management 38 3.2.2 Exercise therapies 43 3.2.3 Postural therapies 52 3.2.4 Orthotics and appliances 57 3.2.5 Manual Therapies 61 3.2.6 Acupuncture 72 3.2.7 Electrotherapies 77 3.2.8 Psychological interventions 86 3.2.9 Multidisciplinary biopsychosocial rehabilitation (MBR) programs 90 3.2.10 Return to work programs 98 3.2.11 Back schools 101 3.3 MEDICATIONS 102 KCE Report 287 Low back pain and radicular pain 3 3.3.1 Non-steroidal anti-inflammatory drugs (...) and the regional variation in surgery rate observed in Belgium stressed the need to include invasive interventions in the guideline. Moreover, another KCE project focusing on the elaboration of a care pathway for low back pain had to be based on recent Belgian recommendations. Therefore it was decided to enlarge the scope to the evaluation and the management of low back pain by all kind of interventions. Another point of discussion was the definition of the affection aimed by this guideline. It was decided

2017 Belgian Health Care Knowledge Centre

99. Palliative care for adults: strong opioids for pain relief

are not suitable and analgesic requirements are stable, supported by specialist advice where needed. 1.1.12 This recommendation has been replaced by recommendation 1.5.6 in NICE's guideline on controlled drugs: safe use and management. Palliative care for adults: strong opioids for pain relief (CG140) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 9 of 20First-line treatment if oral opioids are not suitable – subcutaneous (...) will address first-line treatment with strong opioids for patients who have been assessed as requiring pain relief at the third level of the WHO pain ladder. It will not cover second- line treatment with strong opioids where a change in strong opioid treatment is required because of inadequate pain control or significant toxicity. A number of strong opioids are licensed in the UK. However for pain relief in palliative care a relatively small number are commonly used. This guideline has therefore looked

2012 National Institute for Health and Clinical Excellence - Clinical Guidelines

100. A Comparative Effectiveness Randomised Placebo Controlled Pilot Trial of the Management of Acute Lumbar Radicular Pain

personnel except the radiologist delivering the procedure and the investigator responsible for randomisation will be masked to the randomisation arm. The participant, study personnel, other investigators, participant's treating physician and study analyst will be blind to the results. Primary Purpose: Treatment Official Title: A Comparative Effectiveness Randomised Placebo Controlled Pilot Trial of the Management of Acute Lumbar Radicular Pain: Evaluate Route Versus Pharmacology of Intervention (...) A Comparative Effectiveness Randomised Placebo Controlled Pilot Trial of the Management of Acute Lumbar Radicular Pain A Comparative Effectiveness Randomised Placebo Controlled Pilot Trial of the Management of Acute Lumbar Radicular Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2017 Clinical Trials

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