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Topical Analgesic

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61. Immersive Virtual Reality Intervention for Non-Opioid Pain Management: A Randomized Controlled Trial

Trial) Actual Enrollment : 140 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Immersive Virtual Reality Intervention for Non-Opioid Pain Management: A Randomized Controlled Trial Actual Study Start Date : November 16, 2016 Actual Primary Completion Date : July 17, 2017 Actual Study Completion Date : August 17, 2017 Resource links provided by the National Library of Medicine related topics: Arms (...) Immersive Virtual Reality Intervention for Non-Opioid Pain Management: A Randomized Controlled Trial Immersive Virtual Reality Intervention for Non-Opioid Pain Management: A Randomized Controlled Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2016 Clinical Trials

62. Expectations, effect and experiences of an easily accessible self-management intervention for people with chronic pain: study protocol for a randomised controlled trial with embedded qualitative study. Full Text available with Trip Pro

Expectations, effect and experiences of an easily accessible self-management intervention for people with chronic pain: study protocol for a randomised controlled trial with embedded qualitative study. People struggling with chronic pain may benefit from different types of non-pharmacological interventions such as self-management courses. Self-management courses aim to increase participants' skills and knowledge in managing chronic conditions. Community health-care services in Norway have (...) increasingly established Healthy Life Centres (HLCs) to offer easily accessible interventions to people in need of support to better handle a life with chronic illness. The aim of this trial is to investigate the expectations, effect and experience of an easily accessible, group-based self-management course delivered at a HLC for people with chronic pain.This is an open pragmatic two-armed randomised controlled trial with an embedded qualitative study. The intervention is a self-management course

2016 Trials Controlled trial quality: predicted high

63. A Pilot Study of Motor Control Exercise and Patient Education for the Management of Chronic Low Back Pain in Rural Nigerian Community.

to participants' treatment allocation Primary Purpose: Treatment Official Title: Motor Control Exercise and Patient Education for the Management of Chronic Low Back Pain in a Low-Resource Rural Nigerian Community: A Pilot Randomized Controlled Trial. Actual Study Start Date : January 20, 2018 Actual Primary Completion Date : April 30, 2018 Actual Study Completion Date : May 1, 2018 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention (...) A Pilot Study of Motor Control Exercise and Patient Education for the Management of Chronic Low Back Pain in Rural Nigerian Community. A Pilot Study of Motor Control Exercise and Patient Education for the Management of Chronic Low Back Pain in Rural Nigerian Community. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning

2018 Clinical Trials

64. Pre-operative Analgesics for Postoperative Pain Relief After Dental Treatment

Pre-operative Analgesics for Postoperative Pain Relief After Dental Treatment Pre-operative Analgesics for Postoperative Pain Relief After Dental Treatment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) analgesic and by phone 2.5 hours after taking the pre-operative analgesic. The patient and his parents will be asked if the child is crying (yes/no), complaining about pain (yes/no), needed a different kind of analgesics after the treatment (yes/no). In addition, each child will describe his ⁄ her feelings regarding postoperative pain, using the Wong-Baker Facial Rating Pain Scale Condition or disease Intervention/treatment Phase Pain, Postoperative Analgesia Drug: paracetamol Drug: placebo Early Phase

2015 Clinical Trials

65. Pain Control after Intravitreal Injection Using Topical Nepafenac 0.3% or Pressure Patching: A Randomized, Placebo-Controlled Trial. (Abstract)

Pain Control after Intravitreal Injection Using Topical Nepafenac 0.3% or Pressure Patching: A Randomized, Placebo-Controlled Trial. Pain after an intravitreal injection (IVI) can last up to 7 days and negatively impacts the patient's experience, potentially reducing treatment compliance. We prospectively evaluated topical nepafenac 0.3% suspension and patching for the reduction of pain after IVI.Randomized controlled trial.Sixty patients receiving an IVI of bevacizumab, aflibercept (...) , or triamcinolone acetonide in 1 eye.Participants were randomized equally to receive either a single drop of nepafenac 0.3%, a pressure patch for 2 hours, or a single drop of preservative-free artificial tears (control group). A single-blinded placebo-controlled design was used to mask the topical treatment used. Pain was assessed using the Numeric Pain Rating Scale that ranged from 0 to 10 (horizontal pain scale). Because pain scores were not normally distributed, statistical analysis was performed using

2019 Ophthalmology. Retina Controlled trial quality: predicted high

66. Topical anesthesia or oral dextrose for the relief of pain in screening for retinopathy of prematurity: a randomized controlled double-blinded trial. Full Text available with Trip Pro

Topical anesthesia or oral dextrose for the relief of pain in screening for retinopathy of prematurity: a randomized controlled double-blinded trial. Compare efficacy of 0.5% proparacaine eye drops and oral 25% dextrose in reducing pain during screening for retinopathy of prematurity (ROP).Double-blinded randomized controlled trial. Twenty eligible babies were randomized. Group I received 0.5% proparacaine eye drops at first ROP screening, while Group II received 25% dextrose orally. At second (...) examination, babies received no intervention. Pain was assessed using Premature Infant Pain Profile (PIPP) score.The mean ( ± SD) PIPP during procedure in Group I were 15.5 ± 2.06 and 14 ± 2.4 at first and second screening (p = 0.259). The mean ( ± SD) PIPP in Group II were 14.2 ± 1. 8 and 14.9 ± 2.5 at the first and second screening (p = 0.428). Differences were not statistically significant. The PIPP scores of Group I and Group II at the first screening were also not significantly different (p = 0.165

2015 Journal of tropical pediatrics Controlled trial quality: uncertain

67. Novel topical formulation of lidocaine provides significant pain relief for intrauterine device insertion: pharmacokinetic evaluation and randomized placebo-controlled trial. (Abstract)

Novel topical formulation of lidocaine provides significant pain relief for intrauterine device insertion: pharmacokinetic evaluation and randomized placebo-controlled trial. To investigate the pharmacokinetics, safety, and analgesic efficacy of a novel topical formulation of lidocaine at insertion of an intrauterine device (IUD).Randomized controlled trial; phase-I and phase-II studies.University and public hospitals.Women aged ≥18 years who wanted to receive an IUD. Four women were parous (...) concentration: 68 ± 41 minutes; and area under the concentration-time curve from 0 to 180 minutes: 717 ± 421 ng*h/mL. Pain relief was observed with lidocaine vs. placebo in the phase-II study (218 women, randomized). Mean visual analog scale score for maximum pain during the first 10 minutes after IUD insertion was 36% lower with lidocaine than with placebo (28.3 ± 24.6 vs. 44.2 ± 26.0). Pain intensity was also significantly lower in the lidocaine group at 30 minutes. On average, 3 of 4 patients will have

2015 Fertility and sterility Controlled trial quality: predicted high

68. Preclinical evaluations on the efficacy of a topical Chinese herbal formula for swelling control and pain relief. (Abstract)

Preclinical evaluations on the efficacy of a topical Chinese herbal formula for swelling control and pain relief. Patients suffering from musculoskeletal pain and swellings occupy many hospital beds and demand many rehabilitation facilities. Chinese Medicine is offering many alternatives to ameliorate pain and swelling. However, evidence-based scientific publications supporting their efficacy on pain relief are inadequate. The in vitro and in vivo efficacy of a topical use Chinese herbal bath (...) sprout number in the embryos of zebrafish by 2.4 folds. The in vivo therapeutic effects of HB on edema was illustrated by the significant longer thermal withdrawal latency and thinner paw thickness compared with control. After 14 days of treatment, HB also reduced the IL-6 concentration in the serum of rat by 20.9% significantly.This study showed that HB is effective for swelling control and pain relief from edema due to its anti-inflammatory and pro-angiogenic properties.Copyright © 2015 Elsevier

2015 Journal of Ethnopharmacology

69. Improving the self-management of chronic pain: COping with persistent Pain, Effectiveness Research in Self-management (COPERS) Full Text available with Trip Pro

Improving the self-management of chronic pain: COping with persistent Pain, Effectiveness Research in Self-management (COPERS) Improving the self-management of chronic pain: COping with persistent Pain, Effectiveness Research in Self-management (COPERS) Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search (...) a response to this publication, please do so using the form below: Comments submitted to the NIHR Journals Library are electronic letters to the editor. They enable our readers to debate issues raised in research reports published in the Journals Library. We aim to post within 2 working days all responses that contribute substantially to the topic investigated, as determined by the Editors. Your name and affiliations will be published with your comment. Once published, you will not have the right

2016 NIHR HTA programme

70. Innovations in topical ocular corticosteroid therapy for the management of postoperative ocular inflammation and pain. (Abstract)

Innovations in topical ocular corticosteroid therapy for the management of postoperative ocular inflammation and pain. Topical ophthalmic corticosteroids are of clinical benefit in the management of pain and inflammation after ocular surgery; however, their use can be associated with class-associated adverse events (AEs) and limited bioavailability. Selection of an appropriate topical corticosteroid depends on drug-specific variables such as AE profile, efficacy, potency, dosing, patient (...) etabonate (LE) is a carbon-20 ester corticosteroid developed through retrometabolic drug design with potent anti-inflammatory effects and a reduced propensity for eliciting corticosteroid class AEs. This drug has been formulated for topical ophthalmic use after surgery as 0.5% and 1% suspensions, a 0.5% ointment, and a 0.5% gel. Preclinical and clinical data for a new 0.38% LE gel will be reviewed demonstrating that reducing the drug particle size to the nanometer range in diameter provides effective

2019 American Journal Of Managed Care

71. Topical cryoanesthesia for the relief of pain caused by steroid injections used to treat hypertrophic scars and keloids. Full Text available with Trip Pro

Topical cryoanesthesia for the relief of pain caused by steroid injections used to treat hypertrophic scars and keloids. Intralesional steroid injections are the standard treatment for hypertrophic scars and keloids. The procedure is, however, quite painful and is unpopular with patients because of this. Topical application of anesthetic creams, such as Ametop gel (tetracaine) and EMLA cream (lidocaine and prilocaine), has limited efficacy because of poor drug penetration. The onset (...) of the analgesic effect is also slow, which means that the use of topical anesthetics is time-consuming in clinical practice.We hypothesized that a commercially available cryotip could be used to provide fast-acting topical cryoanesthesia that would reduce the pain associated with steroid injections.Thirty patients with hypertrophic scars or keloids were enrolled in the study. Scars were injected with the steroid, triamcinolone acetonide, with or without prior application of the cryotip (-10 °C) for 15 seconds

2017 Medicine Controlled trial quality: uncertain

72. Salicylate Poisoning Potential of Topical Pain Relief Agents: From Age Old Remedies to Engineered Smart Patches Full Text available with Trip Pro

Salicylate Poisoning Potential of Topical Pain Relief Agents: From Age Old Remedies to Engineered Smart Patches The pain relief capabilities of methyl salicylate are well established and a multitude of over-the-counter products populate pharmacy shelves. Over-application of the topical preparation containing the drug, or its accidental ingestion, invariably result in salicylate poisoning and in severe cases can be fatal. The drug has been a regular feature of the US National Poison Database

2017 Medicines

73. Prescribing for rheumatological conditions in pregnancy and breastfeeding - Part II: analgesics and other drugs used in rheumatology practice. Full Text available with Trip Pro

and breastfeeding, see the BSR and BHPR guideline part I [ ]. Target audience Health professionals directly involved in managing patients with rheumatic disease in the UK who are or are planning to become pregnant and/or breastfeeding, men planning to conceive and patients who have accidentally conceived while taking these medications. Areas the guideline does not cover This guideline does not cover the management of infertility; acute pain relief during labour, hence morphine was excluded; or the indications (...) Prescribing for rheumatological conditions in pregnancy and breastfeeding - Part II: analgesics and other drugs used in rheumatology practice. We use cookies to enhance your experience on our website. By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time. BSR and BHPR guideline on prescribing drugs in pregnancy and breastfeeding—Part II: analgesics and other drugs used in rheumatology practice | Rheumatology | Oxford Academic

2016 British Society for Rheumatology

74. Nerve Blocks for Management of Pain Following Hip Fracture

a sign of relief. But what nerve block? And will it work? You nod smartly in agreement and excuse yourself to the bathroom to check out some online resources… PICO Question Population: Elderly patients with acute hip fracture in the emergency department Intervention: Regional nerve block with any local anesthetic for analgesia (femoral nerve block, 3-in-1 nerve block, or fascia iliaca block) Comparison: Standard pain management strategy without regional nerve block Outcome: Pain scores during ED (...) Medicine, including Dr. Jason Snyder from Trauma Surgery. PGY-I This was the only systematic review evaluated. Meta-analysis was not performed due to differences in regional nerve block methods used and pain assessment techniques. Seven ED-based RCT’s of overall low quality demonstrate immediate and sustained pain relief with either single femoral nerve block or continuous catheter infused femoral nerve block. In addition, less rescue opioid analgesia is required. For now, the benefits appear

2020 Washington University Emergency Medicine Journal Club

75. No sufficient evidence for or against providing preoperative analgesics for some dental procedures with local anesthetic in pediatric patients

specialties and certifying boards Evidence Education * Associated Topics No sufficient evidence for or against providing preoperative analgesics for some dental procedures with local anesthetic in pediatric patients Julie M. Coe, DDS, MS, MBA . Overview Systematic Review Conclusion The available evidence is not conclusive in determining whether preoperative analgesics are beneficial to pediatric patients having dental procedures with local anesthetic. Critical Summary Assessment This and of limited (...) No sufficient evidence for or against providing preoperative analgesics for some dental procedures with local anesthetic in pediatric patients No sufficient evidence for or against providing preoperative analgesics for some dental procedures with local anesthetic in pediatric patients ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice

2015 ADA Center for Evidence-Based Dentistry

76. No sufficient evidence for or against providing preoperative analgesics for some dental procedures with local anesthetic in pediatric patients

specialties and certifying boards Evidence Education * Associated Topics No sufficient evidence for or against providing preoperative analgesics for some dental procedures with local anesthetic in pediatric patients Julie M. Coe, DDS, MS, MBA . Overview Systematic Review Conclusion The available evidence is not conclusive in determining whether preoperative analgesics are beneficial to pediatric patients having dental procedures with local anesthetic. Critical Summary Assessment This and of limited (...) No sufficient evidence for or against providing preoperative analgesics for some dental procedures with local anesthetic in pediatric patients No sufficient evidence for or against providing preoperative analgesics for some dental procedures with local anesthetic in pediatric patients ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice

2015 ADA Center for Evidence-Based Dentistry

77. No sufficient evidence for or against providing preoperative analgesics for some dental procedures with local anesthetic in pediatric patients

specialties and certifying boards Evidence Education * Associated Topics No sufficient evidence for or against providing preoperative analgesics for some dental procedures with local anesthetic in pediatric patients Julie M. Coe, DDS, MS, MBA . Overview Systematic Review Conclusion The available evidence is not conclusive in determining whether preoperative analgesics are beneficial to pediatric patients having dental procedures with local anesthetic. Critical Summary Assessment This and of limited (...) No sufficient evidence for or against providing preoperative analgesics for some dental procedures with local anesthetic in pediatric patients No sufficient evidence for or against providing preoperative analgesics for some dental procedures with local anesthetic in pediatric patients ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice

2015 ADA Center for Evidence-Based Dentistry

78. Intranasal Versus Intravenous Administration of Anxiolytic or Analgesic Medications

for lorazepam, IN lorazepam was found to be non-inferior to IV lorazepam for the termination of seizures in children presenting to the ED. No information was identified regarding the use of intranasal anxiolytics for adult patients. Intranasal Analgesics Three systematic reviews 1-3 examined the use of IN analgesics for pain management. In the ED, IN fentanyl demonstrated analgesic non-inferiority to IV morphine for moderate to severe pain. 1 In the pre-hospital setting, IN fentanyl was found to be both (...) inferior and non-inferior as compared to IV morphine and demonstrated a significant analgesic effect when compared with methoxyflurane. 1 When used for the management of acute pain following long bone fracture in children, IN fentanyl showed no significant analgesic difference as compared to IV morphine. 2 When used for children, the pain scores following administration of IN fentanyl were similar or better than those reported following administration of other opioids. 3 It was unclear whether

2014 Canadian Agency for Drugs and Technologies in Health - Rapid Review

79. The Effects of Optimizing Post-operative Pain Management With Multi Modal Analgesia on Immune Suppression and Oncologic Outcome in Patients Undergoing Laparoscopic Colorectal Surgery

decade to reduce the dose of narcotic analgesics and to increase the effectiveness of pain control, since studies of anesthetics and narcotic analgesics have shown immunosuppressive effects. This study investigate the effect of multimodal analgesics for postoperative pain control on immune function amd prognosis in patients undergoing laparoscopic colorectal cancer resection. Condition or disease Intervention/treatment Phase Laparoscopic Colorectal Resection Due to Cancer Drug: IV ketamine/lidocaine (...) /IV PCA apply Drug: IV PCA only apply Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 100 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Triple (Participant, Care Provider, Investigator) Primary Purpose: Treatment Official Title: The Effects of Optimizing Post-operative Pain Management With Multi Modal Analgesia on Immune Suppression and Oncologic Outcome in Patients

2018 Clinical Trials

80. Impact of Suggestion on the Human Experimental Model of Cold Hyperalgesia after Topical Application of High-Concentration Menthol [40%]. (Abstract)

Impact of Suggestion on the Human Experimental Model of Cold Hyperalgesia after Topical Application of High-Concentration Menthol [40%]. Human experimental pain models in healthy subjects offer unique possibilities to study mechanisms of pain within a defined setting of expected pain symptoms, signs and mechanisms. Previous trials in healthy subjects demonstrated that topical application of 40% menthol is suitable to induce cold hyperalgesia. The objective of this study was to evaluate (...) the impact of suggestion on this experimental human pain model.The study was performed within a single-centre, randomized, placebo-controlled, double-blind, two-period crossover trial in a cohort of 16 healthy subjects. Subjects were tested twice after topical menthol application (40% dissolved in ethanol) and twice after ethanol (as placebo) application. In the style of a balanced placebo trial design, the subjects received during half of the testing the correct information about the applied substance

2018 European Journal of Pain Controlled trial quality: uncertain

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