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Topical Analgesic

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41. Design and evaluation of lidocaine- and prilocaine-coloaded nanoparticulate drug delivery systems for topical anesthetic analgesic therapy: a comparison between solid lipid nanoparticles and nanostructured lipid carriers Full Text available with Trip Pro

Design and evaluation of lidocaine- and prilocaine-coloaded nanoparticulate drug delivery systems for topical anesthetic analgesic therapy: a comparison between solid lipid nanoparticles and nanostructured lipid carriers Topical anesthesia analgesic therapy has diverse applicability in solving the barrier properties of skin and unfavorable physicochemical properties of drugs. Lidocaine (LID) combined with prilocaine (PRI) has been used as a topical preparation for dermal anesthesia (...) evaluated and compared.Results revealed that combination delivery of the dual drugs exhibited more remarkable efficiency than signal drug-loaded systems. SLN systems have better ex vivo skin permeation ability than NLCs. NLC systems revealed a stronger in vivo anesthesia analgesic effect than SLN systems.It can be concluded that SLNs and NLCs have different advantages, and that both carriers are promising dual drug delivery systems for topical anesthetic analgesic therapy.

2017 Drug design, development and therapy

42. Anti-inflammatory and Analgesic Activities of Topical Formulations of Pterocarpus Santalinus Powder in Rat Model of Chronic Inflammation Full Text available with Trip Pro

Anti-inflammatory and Analgesic Activities of Topical Formulations of Pterocarpus Santalinus Powder in Rat Model of Chronic Inflammation The incidence of arthritis is quite high and there is a need for the search of natural products to halt the progression of disease or provide symptomatic relief without significant adverse effects.This study aimed at evaluating the anti-inflammatory and analgesic activities of topical Pterocarpus santalinus in an animal model of chronic inflammation.Albino (...) rats of either sex were divided into five groups of six rats each (Group I - Control, Group II -Gel base, Group III -P. santalinus paste, Group IV -P. santalinus gel, Group V- Diclofenac gel). Chronic inflammation was induced on day 0 by injecting 0.1 ml Complete Freund's Adjuvant (CFA) in sub-plantar tissue of left hind paw of the rats. Topical treatment was started from day 12 till day 28. Body weight and paw volume (Plethysmometer) were assessed on day 0, 12 and 28. Pain assessment was done

2017 Journal of clinical and diagnostic research : JCDR

43. Bottlenecks in the development of topical analgesics: molecule, formulation, dose-finding, and phase III design Full Text available with Trip Pro

, and, unfortunately, such trials are missing. In fact, we will demonstrate that underdosing is one of the major hurdles to detect meaningful and statistically relevant clinical effects of topical analgesics. 4) Selection of clinical end points and innovatively designed phase III trials. End point selection can make or break a trial. For instance, to include numbness together with tingling as a composite end point for neuropathic pain seems stretching the therapeutic impact of an analgesic too far. Given the fast (...) onset of action of topical analgesics (usually within 30 minutes), enrichment designs might enhance the chances for success, as the placebo response might decrease. Topical analgesics may become promising inroads for the treatment of neuropathic pain, once sufficient attention is given to these four key aspects.

2017 Journal of pain research

44. Topical Analgesic Versus Saline Mouth Rinses in Post Extraction Healing

Topical Analgesic Versus Saline Mouth Rinses in Post Extraction Healing Topical Analgesic Versus Saline Mouth Rinses in Post Extraction Healing - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Topical (...) Khan, Aga Khan University Study Details Study Description Go to Brief Summary: There is no evidence based guidelines on using saline rinses for post extraction oral care among hypertensives. Similarly, benefit of orally dissolved topical analgesics in addition to orally administered analgesic is questionable. Condition or disease Intervention/treatment Phase Tooth Extraction Site Healing Drug: Aspirin Powder Drug: Normal saline Early Phase 1 Detailed Description: Objective: To compare the post

2017 Clinical Trials

45. Analgesic Effect of Topical Sodium Diclofenac before Retinal Photocoagulation for Diabetic Retinopathy: A Randomized Double-masked Placebo-controlled Intraindividual Crossover Clinical Trial. Full Text available with Trip Pro

were enrolled. Both treatments were matched regarding the applied laser. Pain sensation based on visual analogue scale was 5.6 ± 3.0 in the treated group and 5.5 ± 3.0 in the control group. The calculated treatment effect was 0.15 (95% confidence interval, -0.27 to 0.58; p = 0.486). The estimated period effect was 0.24 (p = 0.530) and the carryover effect was not significant (p = 0.283).Pretreatment with topical sodium diclofenac 0.1% does not have any analgesic effect during peripheral retinal (...) Analgesic Effect of Topical Sodium Diclofenac before Retinal Photocoagulation for Diabetic Retinopathy: A Randomized Double-masked Placebo-controlled Intraindividual Crossover Clinical Trial. To evaluate the analgesic effect of topical sodium diclofenac 0.1% before retinal laser photocoagulation for diabetic retinopathy.Diabetic patients who were candidates for peripheral laser photocoagulation were included in a randomized, placebo-controlled, intraindividual, two-period, and crossover

2017 Korean journal of ophthalmology : KJO Controlled trial quality: predicted high

46. Topical lidocaine-prilocaine cream versus lidocaine infiltration for pain relief during repair of perineal tears after vaginal delivery: randomized clinical trial. (Abstract)

Topical lidocaine-prilocaine cream versus lidocaine infiltration for pain relief during repair of perineal tears after vaginal delivery: randomized clinical trial. The current study aims to compare the analgesic effect of lidocaine-prilocaine (LP) cream with lidocaine infiltration during repair of perineal tears after vaginal delivery.A single center open-labeled randomized clinical trial was carried out in a tertiary University Hospital between October 2016 and May 2017 (Clinical Trials.Gov (...) : NCT02883179). We included parous women, who delivered at gestational age >37 weeks with first- or second-degree perineal tears. The participants were randomized in a 1:1 ratio to either lidocaine infiltration (Group I); or application of LP cream (Group II) for pain relief during perineal repair. The primary outcome was the difference in mean pain score during perineal repair. Secondary outcomes included the participants' satisfaction, the need for additional anesthesia, the duration of perineal repair

2018 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Controlled trial quality: uncertain

47. REDUCTION OF POSTINTRAVITREAL INJECTION PAIN USING ICE: An Open-Label Interventional Randomized Controlled Trial. (Abstract)

REDUCTION OF POSTINTRAVITREAL INJECTION PAIN USING ICE: An Open-Label Interventional Randomized Controlled Trial. Intravitreal injections of intraocular therapeutic agents are a common and effective treatment for various retinal pathologies. Patient discomfort related to injection is a potential barrier to treatment. Our aim in this study was to evaluate whether cooling the eye using topical ice compresses before intravitreal injection will reduce pain or bleeding.This randomized controlled (...) open-label study included 42 patients. All patients received a standard topical anesthesia protocol and then were randomly assigned to either receive a placement of ice packs (intervention group) or a room-temperature pack (control group) on the eyelid, 2 minutes before the intravitreal injection. Patients' discomfort, itching, burning and pain (using visual analog scale), and bleeding size (using photographs) were measured 1 and 10 minutes after the injection. Tolerability was calculated

2019 Retina Controlled trial quality: uncertain

48. Comparison of Combined Spinal-epidural Analgesia Versus Epidural Analgesia for Pain Management During Labor

analgesia for parturients in the combined spinal-epidural analgesia group. First, the investigator injected a dose of 5 ug sufentanil into cerebrospinal fluid. If no adverse effects were observed 10 minutes after the first dose, the parturient then received mixed liquids of 0.075% ropivacaine and 0.2ug/ml sufentanil citrate through a patient-controlled epidural analgesia (PCA) pump, which provided patients themixed solution at 8-10ml/h to optimize their pain relief until the delivery of neonates (...) of 5ml 1% lidocaine through it. If not adverse effects were observed 10 minutes after the test dose, the parturient then received a bolus injection of an initial dose of 8-10 ml mixed liquids of 0.075% ropivacaine and 0.2ug/ml sufentanil citrate. We then connected the catheter with a patient-controlled epidural analgesia (PCA) pump, which provided patients the same mixed solution at 8-10ml/h to optimize their pain relief until the delivery of neonates. Procedure: Epidural analgesia Epidural analgesia

2018 Clinical Trials

49. Development and evaluation of a web-based acute pain management education program for Korean registered nurses: A randomized controlled trial. (Abstract)

Development and evaluation of a web-based acute pain management education program for Korean registered nurses: A randomized controlled trial. The aim of this randomized controlled trial was to develop a web-based acute pain management education program for nurses and to evaluate its effectiveness. The developed program consisted of a total duration of 400 min with eight modules and 29 topics in pain management. Fifty nurses from the post-anesthesia care unit in two university-affiliated (...) hospitals in Seoul, Korea were randomly assigned to either the experimental group (n = 25) or the control group (n = 25) and a total of 46 nurses, 23 for each group, completed the pre and post-tests. The pre and post-tests were performed to evaluate the changes of the nurses' knowledge, attitude, and self-efficacy regarding acute pain management. The experimental group showed a significant increase in knowledge and in self-efficacy about pain management compared to the control group (u = 389.0, p = .006

2019 Nurse education in practice Controlled trial quality: uncertain

50. Efficacy of Non-pharmacological Methods of Pain Management in Children Undergoing Venipuncture in a Pediatric Outpatient Clinic: A Randomized Controlled Trial of Audiovisual Distraction and External Cold and Vibration. (Abstract)

Efficacy of Non-pharmacological Methods of Pain Management in Children Undergoing Venipuncture in a Pediatric Outpatient Clinic: A Randomized Controlled Trial of Audiovisual Distraction and External Cold and Vibration. Venipuncture generates anxiety and pain in children. The primary aim of the study was to evaluate two non-pharmacological techniques, vibration combined with cryotherapeutic topical analgesia by means of the Buzzy® device and animated cartoons, in terms of pain and anxiety relief (...) . Notably, the difference was statistically significant in the animated cartoon group for children's perception of pain. Children's anxiety and parents' anxiety decreased more in non-pharmacological interventions groups as compared to the group without intervention.The study showed the effectiveness of non-pharmacological methods of pain management during venipuncture. Notably, distraction with animated cartoons was superior in terms of children's perception of pain when compared to Buzzy®

2019 Journal of pediatric nursing Controlled trial quality: uncertain

51. External cold and vibration for pain management of children undergoing needle-related procedures in the emergency department: a randomised controlled non-inferiority trial protocol. Full Text available with Trip Pro

is essential. Therefore, it is important to have interventions that are rapid, easy-to-use and likely to be translated into clinical practice for routine use. The aim of this study will be to determine whether a device combining cold and vibration (Buzzy) is non-inferior to a topical anaesthetic (liposomal lidocaine 4% cream) for pain management of children undergoing needle-related procedures in the emergency department.This study will be a randomised controlled non-inferiority trial comparing the Buzzy (...) External cold and vibration for pain management of children undergoing needle-related procedures in the emergency department: a randomised controlled non-inferiority trial protocol. Needle-related procedures are considered as the most important source of pain and distress in children in hospital settings. Considering the physiological and psychological consequences that could result from these procedures, management of pain and distress through pharmacological and non-pharmacological methods

2019 BMJ open Controlled trial quality: predicted high

52. Corticosteroids Provide Better Postoperative Endodontic Pain Relief Compared to Placebo (CAT#3350)

and dosages of corticosteroids produced different levels of analgesic efficacy. The three main types of corticosteroids studied in this article were prednisolone, dexamethasone, and betamethasone. At 6 hours, prednisolone had a more significant effect on pain relief than the other two drugs due to faster onset. It is speculated that this was because prednisolone has a shorter half-life and diffuses across the cell membrane at a faster rate to affect gene transcription. Applicability This topic (...) Corticosteroids Provide Better Postoperative Endodontic Pain Relief Compared to Placebo (CAT#3350) UTCAT3350, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Corticosteroids Provide Better Postoperative Endodontic Pain Relief Compared to Placebo Clinical Question In patients receiving non-surgical endodontic therapy, do corticosteroids provide better postoperative endodontic pain relief compared to placebo? Clinical

2018 UTHSCSA Dental School CAT Library

53. Pilot Study of a Robot-assisted Intervention for the Management of Care-induced Pain in Dementia

links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Arm AB : Intervention under study x Control intervention Subjects receive intervention A during which they will benefit from a systemic pain assessment and from the PARO robot as a therapeutic mediator, followed by intervention B during which patients will benefit from a systemic pain assessment without the PARO robot. Behavioral: A : Systemic evaluation of the pain (...) Pilot Study of a Robot-assisted Intervention for the Management of Care-induced Pain in Dementia Pilot Study of a Robot-assisted Intervention for the Management of Care-induced Pain in Dementia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2018 Clinical Trials

54. Development of an Intervention to Enhance Cancer Pain Management

Cancer Pain Management Actual Study Start Date : April 15, 2014 Estimated Primary Completion Date : November 30, 2020 Estimated Study Completion Date : November 30, 2022 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment No Intervention: Enhancing Cancer Pain Management Part 1 Will collect information from participants via self-report assessment at two time points: at baseline (i.e. study enrollment) and approximately 8 (...) Development of an Intervention to Enhance Cancer Pain Management Development of an Intervention to Enhance Cancer Pain Management - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Development

2018 Clinical Trials

55. Randomized, Multi-Dose, Placebo-Controlled OA Knee Pain Relief Study of 0.25% 920-CGS-200

Randomized, Multi-Dose, Placebo-Controlled OA Knee Pain Relief Study of 0.25% 920-CGS-200 Randomized, Multi-Dose, Placebo-Controlled OA Knee Pain Relief Study of 0.25% 920-CGS-200 - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) LLC Collaborator: Palm Beach CRO Information provided by (Responsible Party): Vizuri Health Sciences LLC Study Details Study Description Go to Brief Summary: This is a study of a OTC TFM compliant, capsaicin-based (0.25%) topical analgesic for management of osteoarthritis (OA) knee pain (OAKP). Subjects meeting the inclusion criteria and not meeting the exclusion criteria will be randomized into one of four groups: once daily treatment with active product, once daily treatment with product vehicle

2017 Clinical Trials

56. Pain Relief for Birth Control Implants Insertion

Intervention Model: Parallel Assignment Masking: Single (Participant) Primary Purpose: Treatment Official Title: Topical Lidocaine-prilocaine Cream Versus Lidocaine Infiltration for Pain Relief During Insertion of Subcutaneous Birth Control Implants : A Randomized Controlled Trial Actual Study Start Date : June 12, 2017 Estimated Primary Completion Date : September 16, 2018 Estimated Study Completion Date : September 18, 2018 Resource links provided by the National Library of Medicine related topics (...) Pain Relief for Birth Control Implants Insertion Pain Relief for Birth Control Implants Insertion - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Pain Relief for Birth Control Implants Insertion The safety

2017 Clinical Trials

57. Systematic review with meta-analysis: Topical NSAIDS provide effective pain relief for patients with hand or knee osteoarthritis with similar efficacy, and fewer side effects, than oral NSAIDS Full Text available with Trip Pro

Systematic review with meta-analysis: Topical NSAIDS provide effective pain relief for patients with hand or knee osteoarthritis with similar efficacy, and fewer side effects, than oral NSAIDS Topical NSAIDS provide effective pain relief for patients with hand or knee osteoarthritis with similar efficacy, and fewer side effects, than oral NSAIDS | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie (...) settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Topical NSAIDS provide effective pain

2013 Evidence-Based Medicine

58. Would repeat steroid injections be more beneficial than physiotherapy targeted exercise for 'Trochanteric bursitis/trochanteric pain syndrome' (TPS)' in older females giving pain relief for over six months duration?

Would repeat steroid injections be more beneficial than physiotherapy targeted exercise for 'Trochanteric bursitis/trochanteric pain syndrome' (TPS)' in older females giving pain relief for over six months duration? RWT CAT group: Sarah Atkins & Vicky Cooper Date CAT completed October 2016 Date CAT to be reviewed October 2018 Musculoskeletal Research Facilitation Group (CAT Group) Critically appraised topic and clinical bottom line October 2016 Specific Question: Would repeat steroid injections (...) be more beneficial than physiotherapy targeted exercise for trochanteric bursitis/trochanteric pain syndrome (TPS) in older females giving pain relief for over six months duration? Clinical bottom line The search revealed no evidence to answer this question or inform a change in practice. Further research is required. In the absence of evidence management for each patient is on a case by case basis Why is this important? Corticosteriod injections are commonly used in the management of trochanteric

2016 Public Health England

59. Topical Analgesic

Topical Analgesic Topical Analgesic Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Topical Analgesic Topical Analgesic Aka: Topical (...) Analgesic From Related Chapters II. Cost Topical Analgesics are expensive (even for generics) and often not covered by insurance As of 2015, monthly costs may range from $100 patches to >$1500 for Pensaid ( ) Least expensive options 4% patches (e.g. 4%) - OTC III. Preparations : Diclofenac (Pensaid 1.5%) (Voltaren Gel 1.5%) ( ) (5% ) Limited to 12 hour application per day Cost >$100 per 30 generic patches (2015) However, OTC 4% patches (e.g. 4%) cost only $3 per patch Unclear efficacy compared with 5

2018 FP Notebook

60. Topical analgesics in the treatment of knee osteoarthritis: a systematic review and guidelines

Topical analgesics in the treatment of knee osteoarthritis: a systematic review and guidelines Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address (...) screening of the eligible articles for final inclusion. In each phase, 2 observers will independently assess each article. Discrepancies will be resolved through discussion, or by consulting a third investigator. ">Procedure for study selection Example : Title-abstract screening: 1. Not an original full research paper (e.g. review, editorial) 2. Not an in vivo animal study 3. No metastases/ only primary tumor 4. No control group 5. Combination therapy or contamination 6. Not about analgesics used

2018 PROSPERO

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