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Topical Analgesic

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41. Presence of hyperalgesia predicts analgesic efficacy of topically applied capsaicin 8% in patients with peripheral neuropathic pain. (PubMed)

Presence of hyperalgesia predicts analgesic efficacy of topically applied capsaicin 8% in patients with peripheral neuropathic pain. Topical high-dose capsaicin acting on TRPV1 receptors and inducing an intraepidermal decrease in the small nerve fibre count is effective in treating neuropathic pain (NP). Sensory changes after capsaicin application, their correlation with pain relief and their role as possible predictors of response have been insufficiently analysed. We hypothesized a positive

2015 European Journal of Pain

42. Analgesic effects of topical ketamine. (PubMed)

Analgesic effects of topical ketamine. Topical analgesics may play an important role in the management of chronic pain and have good tolerability. Systemic ketamine has limited usage as an anesthetic and along with its potential for addiction and dependence has not gained popularity as an analgesic compound. Topical ketamine however, is devoid of serious side effects, and thus can be used in the management of various pain states such as neuropathic pain and complex regional pain syndrome (...) . Despite using high concentrations of topical ketamine, clinically significant side effects are rare. The measured plasma levels of ketamine and norketamine in various studies were mostly below the threshold of detection. Topical ketamine has been used as compounded formulations alone in concentrations from 0.5% to 20% or in combination with other (co-)analgesics. Its efficacy may depend on the choice of vehicle, the concentration and the pain state. Suboptimal concentration of ketamine and suboptimal

2015 Minerva anestesiologica

43. Analgesic effect of preoperative topical nonsteroidal antiinflammatory drugs on postoperative pain after laser-assisted subepithelial keratectomy. (PubMed)

Analgesic effect of preoperative topical nonsteroidal antiinflammatory drugs on postoperative pain after laser-assisted subepithelial keratectomy. To assess the effect of preoperative topical nonsteroidal antiinflammatory drugs (NSAIDs) on postoperative pain after laser-assisted subepithelial keratectomy (LASEK) and to investigate their mechanism.Severance Eye Hospital and Saeyan Eye Clinic, Seoul, South Korea.Prospective randomized clinical trial.Participants in 2 related studies were assessed (...) postoperatively (P < .05). The mean corneal sensitivity was statistically significantly lower in the NSAID-treated eye than in the placebo-treated eye at 1 and 2 hours in Groups 2A and 2C (P < .05).Preoperative administration of topical NSAIDs before LASEK effectively reduces postoperative pain.No author has a financial or proprietary interest in any material or method mentioned.Copyright © 2015 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

2015 Journal of cataract and refractive surgery

44. Topical and peripheral ketamine as an analgesic. (PubMed)

Topical and peripheral ketamine as an analgesic. Ketamine, in subanesthetic doses, produces systemic analgesia in chronic pain settings, an action largely attributed to block of N-methyl-D-aspartate receptors in the spinal cord and inhibition of central sensitization processes. N-methyl-D-aspartate receptors also are located peripherally on sensory afferent nerve endings, and this provided the initial impetus for exploring peripheral applications of ketamine. Ketamine also produces several (...) of neuropathic pain with topical ketamine combinations, there were improvements in some outcomes, but optimal dosing and drug combinations were not clear. Given orally (as a gargle, throat swab, localized peritonsillar injections), ketamine produced significant oral/throat analgesia in controlled trials in postoperative settings. Topical analgesics are likely more effective in particular conditions (patient factors, disease factors), and future trials of topical ketamine should include a consideration

2014 Anesthesia and Analgesia

45. Comparison of analgesic effect of preoperative topical diclofenac and ketorolac on postoperative pain after photorefractive keratectomy. (PubMed)

Comparison of analgesic effect of preoperative topical diclofenac and ketorolac on postoperative pain after photorefractive keratectomy. To investigate changes in the pain-suppressing potency of 2 preoperatively applied topical nonsteroidal antiinflammatory drugs (NSAIDs) after photorefractive keratectomy (PRK) using a time-serial pain-scoring system.Saeyan Eye Center, Seoul, South Korea.Comparative case series.Ninety-four patients were randomly assigned to 2 groups: ketorolac group (ketorolac (...) according to types of NSAIDs. Preemptive topical diclofenac 0.1% was a safe and effective method for post-PRK pain control.No author has a financial or proprietary interest in any material or method mentioned.Copyright © 2014 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

2014 Journal of cataract and refractive surgery

46. Massage therapy plus topical analgesic is more effective than massage alone for hand arthritis pain. (PubMed)

Massage therapy plus topical analgesic is more effective than massage alone for hand arthritis pain. 20 adults were randomly assigned to a massage therapy or a massage therapy plus a topical analgesic application group. Both groups received a weekly massage from a therapist and were taught self-massage (same procedure) to be done by each participant once daily over a four-week period.The massage plus topical analgesic group as compared to the massage group had greater improvement in hand (...) ., 2013), carpal tunnel syndrome (Elliott and Burkett, 2013), and pain related to upper limb arthritis (Field et al., 2013). The purpose of the current study was to determine whether applying a topical analgesic following massage might be more effective than massage alone in treating pain associated with hand arthritis.Copyright © 2013 Elsevier Ltd. All rights reserved.

2014 Journal of bodywork and movement therapies

47. Clinical study to know the efficacy of Amlexanox 5% with other topical Antiseptic, Analgesic and Anesthetic agents in treating minor RAS. (PubMed)

Clinical study to know the efficacy of Amlexanox 5% with other topical Antiseptic, Analgesic and Anesthetic agents in treating minor RAS. To evaluate the efficacy of topical antiinflammatory agent (amlexanox 5%), along with topical antiseptic, analgesic, and anesthetic agent (benzalkonium chloride 0.01%, choline salicylate 8.7% and lidocaine hydrochloride 2%), in promoting ulcer healing, decreasing ulcer size, erythema, pain and recurrence in minor RAS.A randomized control trial was conducted (...) on 100 patients of RAS who fulfilled the inclusion criteria. The number, size, erythema and pain with the ulcer were recorded. Visual analogue scale (VAS) and erythema scale were used to record pain and erythema. 50 patients comprising the study group received anti inflammatory paste (amlexanox 5%) applied four times daily and the control group of 50 patients received topical antiseptic, analgesic, and anesthetic agent (benzalkonium chloride 0.01%, choline salicylate 8.7% and lidocaine hydrochloride

2014 Journal of international oral health : JIOH

48. A randomized, controlled, clinical pilot study assessing the analgesic effect of morphine applied topically onto split-thickness skin wounds. (PubMed)

A randomized, controlled, clinical pilot study assessing the analgesic effect of morphine applied topically onto split-thickness skin wounds. To assess the effect of an opioid administered topically onto a standardized skin wound in patients without significant comorbidity. Findings to date are contradictory, often obtained from multimorbid patients with wounds lacking uniformity.Forty-four patients undergoing surgery for skin grafting were randomly assigned to receive morphine (0.25, 0.75 (...) or 1.25 mg/100 cm(2) wound size) in hydroxyethylcellulose gel or placebo applied onto the excised split-thickness donor wound at the end of surgery. Pain, supplementary systemic opioids and adverse effects were assessed during the first 24 h after application. Healing was examined when the dressings were removed.Morphine doses ranged from 0.25 to 5.4 mg (mean 1.93 ± standard deviation 1.34 mg). No differences in pain scores or use of supplementary analgesics were found between the groups. Serious

2014 The Journal of pharmacy and pharmacology

49. Post-operative analgesic effects of paracetamol, NSAIDs, glucocorticoids, gabapentinoids and their combinations: a topical review. (PubMed)

Post-operative analgesic effects of paracetamol, NSAIDs, glucocorticoids, gabapentinoids and their combinations: a topical review. In contemporary post-operative pain management, patients are most often treated with combinations of non-opioid analgesics, to enhance pain relief and to reduce opioid requirements and opioid-related adverse effects. A diversity of combinations is currently employed in clinical practice, and no well-documented 'gold standards' exist. The aim of the present topical (...) , narrative review is to provide an update of the evidence for post-operative analgesic efficacy with the most commonly used, systemic non-opioid drugs, paracetamol, non-steroidal anti-inflammatory drugs (NSAIDs)/COX-2 antagonists, glucocorticoids, gabapentinoids, and combinations of these. The review is based on data from previous systematic reviews with meta-analyses, investigating effects of non-opioid analgesics on pain, opioid-requirements, and opioid-related adverse effects. Paracetamol, NSAIDs, COX

2014 Acta Anaesthesiologica Scandinavica

50. Psychophysical Correlates of Pain Reduction by Topical Analgesic Compounds

Psychophysical Correlates of Pain Reduction by Topical Analgesic Compounds Psychophysical Correlates of Pain Reduction by Topical Analgesic Compounds - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Psychophysical Correlates of Pain Reduction by Topical Analgesic Compounds The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02322164 Recruitment Status : Completed First Posted : December 23, 2014 Last Update Posted : July 4, 2018 Sponsor: National Center for Complementary and Integrative Health (NCCIH

2014 Clinical Trials

51. Comparison of analgesic effect of preoperative topical diclofenac and ketorolac on postoperative pain after photorefractive keratectomy. (PubMed)

Comparison of analgesic effect of preoperative topical diclofenac and ketorolac on postoperative pain after photorefractive keratectomy. To investigate changes in the pain-suppressing potency of 2 preoperatively applied topical nonsteroidal antiinflammatory drugs (NSAIDs) after photorefractive keratectomy (PRK) using a time-serial pain-scoring system.Saeyan Eye Center, Seoul, South Korea.Comparative case series.Ninety-four patients were randomly assigned to 2 groups: ketorolac group (ketorolac (...) according to types of NSAIDs. Preemptive topical diclofenac 0.1% was a safe and effective method for post-PRK pain control.No author has a financial or proprietary interest in any material or method mentioned.Copyright © 2014 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

2014 Journal of cataract and refractive surgery

52. Evaluation of Skin Permeation and Analgesic Activity Effects of Carbopol Lornoxicam Topical Gels Containing Penetration Enhancer (PubMed)

Evaluation of Skin Permeation and Analgesic Activity Effects of Carbopol Lornoxicam Topical Gels Containing Penetration Enhancer The current study was designed to develop a topical gel formulation for improved skin penetration of lornoxicam (LOR) for enhancement of its analgesic activity. Moreover, the effect of different penetration enhancers on LOR was studied. The LOR gel formulations were prepared by using hydroxylpropyl methylcellulose (HPMC) and carbopol. The carbopol gels in presence (...) formulation (LORF8) enhanced the permeation of LOR significantly. It was observed that LORF3 and LORF8 show similar analgesic activity compared to marketed LOR injection (Xefo). This work shows that LOR can be formulated into carbopol gel in presence of PG and HP β-CD and may be promising in enhancing permeation.

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2014 The Scientific World Journal

53. Preliminary investigations into the analgesic effects of topical ocular 1% morphine solution in dogs and cats. (PubMed)

Preliminary investigations into the analgesic effects of topical ocular 1% morphine solution in dogs and cats. To perform preliminary evaluations into the ocular analgesic effect of topical 1% morphine in a clinical setting and to determine onset, duration and complications.Prospective, randomised, blinded clinical study.Twenty six dogs and seventeen cats, all client-owned.Dogs and cats with corneal ulceration requiring medical treatment or corneal conditions requiring surgery were included (...) and randomly assigned to receive one drop of topical morphine (group M) or base solution (group B). Recordings were made prior to application and at 5, 10, 20, 30, 40, 50 and 60 minutes, then 2, 3, 4, 5 and 6 hours. Corneal aesthesiometry, blink rates and scores for blepharospasm (BLEPH), conjunctival hyperaemia (CH) and lacrimation (LAC) were recorded. Statistical analyses used anova, t-tests and Mann-Whitney U tests as relevant.No significant effect of treatment group on any recordings was found at any

2014 Veterinary anaesthesia and analgesia

54. Topical clonidine for neuropathic pain. (PubMed)

Topical clonidine for neuropathic pain. Clonidine is a presynaptic alpha-2-adrenergic receptor agonist used for many years to treat hypertension and other conditions, including chronic pain. Adverse events associated with systemic use of the drug have limited its application. Topical use of drugs is currently gaining interest, as it may limit adverse events without loss of analgesic efficacy. Topical clonidine (TC) formulations have been investigated recently in clinical trials.The objectives (...) of this review were to assess the analgesic efficacy of TC for chronic neuropathic pain in adults and to assess the frequency of adverse events associated with clinical use of TC for chronic neuropathic pain.We searched the Cochrane Register of Studies (CRS) Online (Cochrane Central Register of Controlled Trials (CENTRAL)), MEDLINE and EMBASE databases, reference lists of retrieved papers and trial registries, and we contacted experts in the field. We performed the most recent search on 17 September 2014.We

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2015 Cochrane

55. Topical lidocaine for neuropathic pain in adults. (PubMed)

Topical lidocaine for neuropathic pain in adults. Lidocaine is a local anaesthetic that is sometimes used on the skin to treat neuropathic pain.To assess the analgesic efficacy of topical lidocaine for chronic neuropathic pain in adults, and to assess the associated adverse events.We searched CENTRAL, MEDLINE, and EMBASE from inception to 1 July 2014, together with the reference lists of retrieved papers and other reviews. We also searched ClinicalTrials.gov and the World Health Organization (...) (WHO) International Clinical Trials Registry Platform (ICTRP) search portal to identify additional published or unpublished data.We included randomised, double-blind studies of at least two weeks' duration comparing any formulation of topical lidocaine with placebo or another active treatment in chronic neuropathic pain. Participants were adults aged 18 and over. We included only full journal publication articles.Two review authors independently extracted efficacy and adverse event data

2014 Cochrane

56. Topical application of honey in the management of chemo/radiotherapy-induced oral mucositis: A systematic review and network meta-analysis

Topical application of honey in the management of chemo/radiotherapy-induced oral mucositis: A systematic review and network meta-analysis Mucositis is an inflammatory response of mucosal epithelial cells to the cytotoxic effects of chemotherapy and radiation therapy. To assess the comparative efficacy of honey for patients with cancer undergoing chemo/radiotherapy-induced oral mucositis through a systematic review and network meta-analysis.A network meta-analysis was used to identify evidence (...) of mucositis, swallowing diary, fungal colonization, bacterial colonisation and analgesic use. And, we did standardize meta-analyses using the random-effects model, later completing the random-effects network meta-analyses by different treatment/control arms.A total of 17 RCTs were eligible (22 analyses), involving 1265 patients and 13 arms. Honey treatment arm significantly increased the therapeutic effect of chemo/radiotherapy-induced moderate-severe oral mucositis (0.25, 0.14-0.46); significant efficacy

2018 EvidenceUpdates

57. No sufficient evidence for or against providing preoperative analgesics for some dental procedures with local anesthetic in pediatric patients

specialties and certifying boards Evidence Education * Associated Topics No sufficient evidence for or against providing preoperative analgesics for some dental procedures with local anesthetic in pediatric patients Julie M. Coe, DDS, MS, MBA . Overview Systematic Review Conclusion The available evidence is not conclusive in determining whether preoperative analgesics are beneficial to pediatric patients having dental procedures with local anesthetic. Critical Summary Assessment This and of limited (...) No sufficient evidence for or against providing preoperative analgesics for some dental procedures with local anesthetic in pediatric patients No sufficient evidence for or against providing preoperative analgesics for some dental procedures with local anesthetic in pediatric patients ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice

2015 ADA Center for Evidence-Based Dentistry

58. No sufficient evidence for or against providing preoperative analgesics for some dental procedures with local anesthetic in pediatric patients

specialties and certifying boards Evidence Education * Associated Topics No sufficient evidence for or against providing preoperative analgesics for some dental procedures with local anesthetic in pediatric patients Julie M. Coe, DDS, MS, MBA . Overview Systematic Review Conclusion The available evidence is not conclusive in determining whether preoperative analgesics are beneficial to pediatric patients having dental procedures with local anesthetic. Critical Summary Assessment This and of limited (...) No sufficient evidence for or against providing preoperative analgesics for some dental procedures with local anesthetic in pediatric patients No sufficient evidence for or against providing preoperative analgesics for some dental procedures with local anesthetic in pediatric patients ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice

2015 ADA Center for Evidence-Based Dentistry

59. No sufficient evidence for or against providing preoperative analgesics for some dental procedures with local anesthetic in pediatric patients

specialties and certifying boards Evidence Education * Associated Topics No sufficient evidence for or against providing preoperative analgesics for some dental procedures with local anesthetic in pediatric patients Julie M. Coe, DDS, MS, MBA . Overview Systematic Review Conclusion The available evidence is not conclusive in determining whether preoperative analgesics are beneficial to pediatric patients having dental procedures with local anesthetic. Critical Summary Assessment This and of limited (...) No sufficient evidence for or against providing preoperative analgesics for some dental procedures with local anesthetic in pediatric patients No sufficient evidence for or against providing preoperative analgesics for some dental procedures with local anesthetic in pediatric patients ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice

2015 ADA Center for Evidence-Based Dentistry

60. Compounded Diclofenac Cream for Topical Anti-Inflammatory Treatment

. PREPARED BY: Canadian Agency for Drugs and Technologies in Health Tel: 1-866-898-8439 www.cadth.ca Compounded Diclofenac Cream for Topical Anti-Inflammatory Treatment 4 APPENDIX – FURTHER INFORMATION: Health Technology Assessments – Topical Diclofenac 1. Effective Health Care Program. Analgesics for osteoarthritis: an update of the 2006 comparative effectiveness review [Internet]. Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services; 2011 Oct. AHRQ Publication No. 11 (...) Review Articles 13. Safety review of diclofenac [Internet]. Version 2.1. ACT, Australia: Australian Governement Department of Health, Therapeutic Goods Administration; 2014 Oct. [cited 2015 Apr 28]. Available from: http://www.tga.gov.au/sites/default/files/medicines-review-safety- diclofenac_0.docx See: 6. Topical Diclofenac, page 19 14. Argoff CE. Topical analgesics in the management of acute and chronic pain. Mayo Clin Proc. 2013 Feb;88(2):195-205. PubMed: PM23374622 Compounded Diclofenac Cream

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

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