How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

60,138 results for

Topical Analgesic

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

21. Comparison of Analgesic Effects According to Patient-controlled Epidural Analgesia Modes in Patients Undergoing Open Gastrectomy

participating. Read our for details. ClinicalTrials.gov Identifier: NCT03430440 Recruitment Status : Recruiting First Posted : February 12, 2018 Last Update Posted : January 15, 2019 See Sponsor: Yonsei University Information provided by (Responsible Party): Yonsei University Study Details Study Description Go to Brief Summary: Epidural PCA (patient controlled analgesia) for post-operative pain management are effective analgesic method. It is widely used in the postoperative pain management for decades. PCA (...) Comparison of Analgesic Effects According to Patient-controlled Epidural Analgesia Modes in Patients Undergoing Open Gastrectomy Comparison of Analgesic Effects According to Patient-controlled Epidural Analgesia Modes in Patients Undergoing Open Gastrectomy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have

2018 Clinical Trials

22. Relief of pain by oral medications. A controlled evaluation of analgesic combinations. (Abstract)

Relief of pain by oral medications. A controlled evaluation of analgesic combinations. 4599149 1974 08 23 2016 10 17 0098-7484 229 1 1974 Jul 01 JAMA JAMA Relief of pain by oral medications. A controlled evaluation of analgesic combinations. 55-9 Moertel C G CG Ahmann D L DL Taylor W F WF Schwartau N N eng Clinical Trial Journal Article Randomized Controlled Trial United States JAMA 7501160 0098-7484 0 Analgesics 0 Azepines 0 Ethers, Cyclic 0 Morphinans 3G6A5W338E Caffeine I4744080IR (...) Pentobarbital O9M39HTM5W Promazine Q830PW7520 Codeine R16CO5Y76E Aspirin RP4A60D26L Pentazocine S2F83W92TK Dextropropoxyphene AIM IM Administration, Oral Analgesics administration & dosage Aspirin administration & dosage therapeutic use Azepines administration & dosage therapeutic use Caffeine administration & dosage therapeutic use Clinical Trials as Topic Codeine administration & dosage therapeutic use Dextropropoxyphene administration & dosage therapeutic use Drug Therapy, Combination Ethers, Cyclic

1974 JAMA Controlled trial quality: uncertain

23. Topical Analgesia with Lidocaine Plus Diclofenac Decreases Pain in Benign Anorectal Surgery: Randomized, Double-blind, and Controlled Clinical Trial Full Text available with Trip Pro

Topical Analgesia with Lidocaine Plus Diclofenac Decreases Pain in Benign Anorectal Surgery: Randomized, Double-blind, and Controlled Clinical Trial The aim of this study is to evaluate the efficacy and safety of a topical formulation containing lidocaine plus diclofenac (CLIFE1) compared to lidocaine (CLIFE2), to decrease pain in benign anorectal surgery (BARS) to date not evaluated. More than 50% of patients undergoing BARS, especially hemorrhoidectomy, suffer from moderate and severe (...) postoperative pain. This remains an unresolved problem that could be addressed with the new CLIFE1 topical treatment.A multicenter, randomized double-blind, active-controlled parallel-group superiority trial, was conducted in two Spanish hospitals. Patients undergoing BARS (hemorrhoids, anal fistula and anal fissure) were randomized at the end of surgery at a 1:1 ratio to receive first dose either CLIFE1 (n = 60) or CLIFE2 (n = 60) anorectal topical treatment, and after every 12 h for the first three

2018 Clinical and translational gastroenterology Controlled trial quality: predicted high

24. Analgesic Effect of Topical Nepafenac 0.1% on Pain Related to Intravitreal Injections: A Randomized Crossover Study. (Abstract)

Analgesic Effect of Topical Nepafenac 0.1% on Pain Related to Intravitreal Injections: A Randomized Crossover Study. To evaluate the analgesic effect of nepafenac 0.1%, a topical non-steroidal anti-inflammatory agent, in patients undergoing treatment with intravitreal injections (IVIs).It is a single center, prospective, randomized, double-blinded, placebo-controlled, crossover interventional study. Fifty-two patients scheduled to undergo IVI of anti-vascular endothelial growth factors were (...) included in the study. Patients were randomized in a 1:1 ratio to receive topical nepafenac 0.1% or placebo 1 h before subsequent IVIs. Using the short form of the McGill Pain Questionnaire (SF-MPQ), pain intensity was assessed with the Visual Analogue Scale (VAS), the Main Component of the SF-MPQ (MC-SF-MPQ), and the Present Pain Intensity (PPI) scores immediately and 6-h post-injection.The VAS pain score was statistically significant lower immediately and 6-h post-IVI in patients treated

2018 Current eye research Controlled trial quality: uncertain

25. Topical Anti-Inflammatory and Analgesic Activities of Citrullus colocynthis Extract Cream in Rats Full Text available with Trip Pro

Topical Anti-Inflammatory and Analgesic Activities of Citrullus colocynthis Extract Cream in Rats Background and objectives:Citrullus colocynthis (CC), known as bitter apple, is used to treat diabetes in Iranian traditional medicine. The aim of this study is to evaluate the anti-inflammatory and analgesic activities of CC cream in rats. Materials and Methods: The carrageenan-induced edema in a rat hind paw was carried out to evaluate the topical anti-inflammatory effect of the CC fruit extract (...) effect of the CC cream (p < 0.05). Conclusions: For the first time, this study indicated that the topical application of CC cream possesses significant anti-inflammatory and antinociceptive activities in animal models, which were probably mediated by opioid receptors and the suppression of pro-inflammatory cytokines (TNF-α and IL-6). Thus, the CC cream can be used to treat inflammatory pain and inflammatory diseases.

2018 Medicina

26. Pain and analgesic drugs in chronic venous ulcers with topical sevoflurane use. (Abstract)

Pain and analgesic drugs in chronic venous ulcers with topical sevoflurane use. Pain in chronic venous ulcers (CVUs) notably increases with the usual cleaning of the wound. Chronic pain is usually poorly controlled even with the multiple analgesic treatments available. Analgesics can have different serious adverse effects and medical interactions in old patients with several comorbidities. This study reports the efficacy and safety of topical sevoflurane for treatment of pain in CVUs.We report (...) a descriptive and retrospective study of 30 patients older than 65 years with painful CVUs refractory to conventional analgesic treatments. Patients received topical sevoflurane treatment before the usual cleaning of the ulcer. Cleaning visits with sevoflurane every 2 days for a period of 1 month were scheduled. We compared the visual analog scale results and analgesic drugs for cleaning with and without topical sevoflurane. The systemic pharmacokinetics of sevoflurane after topical application has not been

2018 Journal of Vascular Surgery

27. EMPOWER: Randomized Trial of Online Chronic Pain Management Program to Reduce Reliance on Opioid Analgesic Medications

to Reduce Morphine Equivalent Dose for Chronic Pain Patients Receiving Opioid-therapy Through a Web-based E-Health Self-management Program: a Randomized Multi-site Clinical Trial in Primary Care Actual Study Start Date : February 5, 2018 Estimated Primary Completion Date : January 2022 Estimated Study Completion Date : January 2022 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment No Intervention: Treatment As Usual (...) EMPOWER: Randomized Trial of Online Chronic Pain Management Program to Reduce Reliance on Opioid Analgesic Medications EMPOWER: Randomized Trial of Online Chronic Pain Management Program to Reduce Reliance on Opioid Analgesic Medications - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2017 Clinical Trials

28. Compounded Topical Pain Creams to Treat Localized Chronic Pain: A Randomized Controlled Trial. (Abstract)

Compounded Topical Pain Creams to Treat Localized Chronic Pain: A Randomized Controlled Trial. The use of compounded topical pain creams has increased dramatically, yet their effectiveness has not been well evaluated.To determine the efficacy of compounded creams for chronic pain.Randomized controlled trials of 3 interventions. (ClinicalTrials.gov: NCT02497066).Military treatment facility.399 patients with localized pain classified by each patient's treating physician as neuropathic (n = 133 (...) , -0.9 to 0.2 points]), or for all patients (-0.3 points [CI, -0.6 to 0.1 points]). At 1 month, 72 participants (36%) in the treatment groups and 54 (28%) in the control group had a positive outcome (risk difference, 8% [CI, -1% to 17%]).Generalizability is limited by heterogeneity among pain conditions and formulations of the study interventions. Randomized follow-up was only 1 month.Compounded pain creams were not better than placebo creams, and their higher costs compared with approved compounds

2019 Annals of Internal Medicine Controlled trial quality: predicted high

29. Topical NSAIDs: good relief for acute musculoskeletal pain

Topical NSAIDs: good relief for acute musculoskeletal pain Topical NSAIDs: good relief for acute musculoskeletal pain - Evidently Cochrane Search and hit Go By June 25, 2015 // Non-steroidal anti-inflammatory drugs (NSAIDs) are routinely prescribed for mild to moderate pain and are the most commonly prescribed painkilling drugs worldwide. Taken by mouth or injected into a vein, the high concentrations of the drug throughout the body, necessary in order to work at the site of pain (...) that topical NSAIDs are an effective and safe means of relieving acute musculoskeletal pain in adults. The new evidence also tells us much more than we knew before about which ones work best. The evidence comes from 61 randomized controlled trials (RCTs) with 8386 people. Several different topical NSAIDs were compared, mostly with placebo in the same carrier – so gel with a drug compared to the gel without a drug, for example. Both would be rubbed into the skin so we know that any effect is not just from

2015 Evidently Cochrane

30. The Efficacy of Lidocaine Spray in Pain Relief during Outpatient-Based Endometrial Sampling: A Randomized Placebo-Controlled Trial Full Text available with Trip Pro

The Efficacy of Lidocaine Spray in Pain Relief during Outpatient-Based Endometrial Sampling: A Randomized Placebo-Controlled Trial Abnormal vaginal bleeding is one of the most frequent problems found in gynecology. Endometrial histopathology is needed for definite diagnosis. It was obtained either from endometrial tissue sampling or from standard uterine curettage. Office endometrial tissue sampling is an easy and low morbid procedure. It is usually associated with pain and discomfort. Topical (...) anesthetic agent is needed for pain relieving. This study was conducted in outpatient gynecology clinic, Thammasat University Hospital, Thailand. It was a double blind randomized controlled trial. A total of 140 participants were enrolled in study and control group. Each group consisted of 70 cases. Study group received topical spray of 10% lidocaine (40 mg) before endometrial aspiration. Topical spray of 0.9% normal saline was performed in control group. Novak curettage was an application

2018 Pain research and treatment Controlled trial quality: predicted high

31. Postoperative Pain Control & Relief in Neonates

: Postoperative Pain Control & Relief in Neonates Estimated Study Start Date : March 1, 2019 Estimated Primary Completion Date : March 1, 2022 Estimated Study Completion Date : March 1, 2022 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Intravenous Acetaminophen Infants randomized to the intervention arm will receive scheduled IV acetaminophen per LexiComp dosing guideline (28 0/7-32 6/7 (...) Postoperative Pain Control & Relief in Neonates Postoperative Pain Control & Relief in Neonates - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Postoperative Pain Control & Relief in Neonates (POPCORN

2018 Clinical Trials

32. Does improvement towards a normal cervical sagittal configuration aid in the management of cervical myofascial pain syndrome: a 1- year randomized controlled trial Full Text available with Trip Pro

Does improvement towards a normal cervical sagittal configuration aid in the management of cervical myofascial pain syndrome: a 1- year randomized controlled trial There is a growing interest concerning the understanding of and rehabilitation of the sagittal configuration of the cervical spine as a clinical outcome. However, the literature on the topic specific to conservative treatment outcomes of patients with chronic myofascial cervical pain syndrome (CMCPS) has not adequately addressed (...) the relationship between cervical sagittal alignment and improved pain, disability and range of motion.A randomized controlled study with a 1-year follow-up. Here, 120 (76 males) patients with chronic CMCPS and defined cervical sagittal posture abnormalities were randomly assigned to the control or an intervention group. Both groups received the Integrated neuromuscular inhibition technique (INIT); additionally, the intervention group received the denneroll cervical traction device. Alignment outcomes included

2018 EvidenceUpdates

33. Multimodal Analgesic Technique for Control of Post-laproscopy Abdominal Pain

Multimodal Analgesic Technique for Control of Post-laproscopy Abdominal Pain Multimodal Analgesic Technique for Control of Post-laproscopy Abdominal Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) only. Pain relief after diagnostic laparoscopy, being a day case, is an issue of great practical importance.The aim of this study is to compare the efficacy of combining both pulmonary recruitment and intraperitoneal lidocaine versus pulmonary recruitment alone to control post - laparoscopy shoulder pain regarding severity and frequency Study Design : Interventional Prospective Randomized Double-blind Controlled Trial Methodology This study is a randomized double blinded control trial

2017 Clinical Trials

34. Efficacy of Pethidine, Ketorolac And Xylocaine Gel As Analgesics For Pain Control In Shockwave Lithotripsy

: May 28, 2018 Sponsor: Mansoura University Information provided by (Responsible Party): Abdelwahab Hashem, Mansoura University Study Details Study Description Go to Brief Summary: A randomised prospective trial comparing the efficacy of pethidine, Ketorolac, and Xylocaine gel as analgesics for pain control in shockwave lithotripsy. Condition or disease Intervention/treatment Phase Analgesia Urolithiasis Drug: Pethidine Drug: Ketorolac Drug: Xylocaine Gel Phase 4 Detailed Description: Pain (...) efficacious type of analgesia for patient during SWL in this study. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 165 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Participant) Primary Purpose: Treatment Official Title: Efficacy of Pethidine, Ketorolac And Xylocaine Gel As Analgesics For Pain Control In Shockwave Lithotripsy Single Blinded Randomized Controlled Trial Actual Study Start

2017 Clinical Trials

35. Comparison of topical lidocaine spray with forced coughing in pain relief during colposcopic biopsy procedure: a randomised trial. (Abstract)

Comparison of topical lidocaine spray with forced coughing in pain relief during colposcopic biopsy procedure: a randomised trial. Our objective was to compare the effectiveness of local lidocaine spray (LS) compared to forced coughing (FC) for relieving the pain during colposcopically guided cervical biopsies (CGBs). The study was a randomised study, which included patients with abnormal cervical cytologic results requiring a colposcopic biopsy procedure. The patients were randomly assigned (...) in the LS and FC groups, respectively (p< .05). The operative time was longer in the LS than in the FC group (7.6 ± 1.4 vs. 5.2 ± 0.8, p: .004). No complication or adverse effect was observed in both groups. The present study showed that LS use can be recommended for pain relief during colposcopically directed cervical biopsy procedure with a superiority to the FC in the terms of pain and absence of any adverse reactions. Impact Statement What is already known on this subject? A colposcopic-guided

2019 Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology Controlled trial quality: uncertain

36. Presence of hyperalgesia predicts analgesic efficacy of topically applied capsaicin 8% in patients with peripheral neuropathic pain. (Abstract)

Presence of hyperalgesia predicts analgesic efficacy of topically applied capsaicin 8% in patients with peripheral neuropathic pain. Topical high-dose capsaicin acting on TRPV1 receptors and inducing an intraepidermal decrease in the small nerve fibre count is effective in treating neuropathic pain (NP). Sensory changes after capsaicin application, their correlation with pain relief and their role as possible predictors of response have been insufficiently analysed. We hypothesized a positive (...) correlation between pain relief and increase in the warmth detection threshold (WDT), indicating loss of C-fibre function, and higher response rates in patients with preserved C-fibre function or heat hyperalgesia before application.Quantitative Sensory Testing (DFNS protocol) was conducted in 20 unilaterally treated patients with peripheral NP (peripheral nerve injury: n = 14, polyneuropathy: n = 4, postherpetic neuralgia: n = 2) before and 2, 4, 6 and 8 weeks after application of capsaicin (8

2015 European Journal of Pain

37. Effect of topical glyceryl trinitrate cream on pain perception during intrauterine device insertion in multiparous women: A randomized double-blinded placebo-controlled study. (Abstract)

Effect of topical glyceryl trinitrate cream on pain perception during intrauterine device insertion in multiparous women: A randomized double-blinded placebo-controlled study. Intrauterine contraceptive device (IUD) insertion-related pain presents a push beyond the decline of women to use IUD for family planning. We aimed to investigate the analgesic effect of glyceryl trinitrate cream (GTN) in reducing pain during IUD insertion.We conducted a randomized double-blinded placebo-controlled study (...) the participant's self-rated pain perception utilizing a 10-cm Visual Analogue Scale (VAS) during cervical tenaculum placement, uterine sound and IUD insertion, then 15 min post-procedure.100 women were enrolled and randomized to GTN arm (n = 50) or placebo (n = 50). Women in the GTN arm reported lower VAS scores during tenaculum placement, sound and IUD insertion (median: 2 vs. 4, p < 0.0001; 2.5 vs. 4.5, p < 0.001;3 vs. 5.5, p < 0.0001, respectively). Higher ease of insertion score was also determined among

2019 Journal of gynecology obstetrics and human reproduction Controlled trial quality: predicted high

38. Effective delivery styles and content for self-management interventions for chronic musculoskeletal pain: a systematic literature review Full Text available with Trip Pro

. Effective delivery styles and content for self-management interventions for chronic musculoskeletal pain: a systematic literature review. Clinical Journal of Pain 2012; 28(4): 344-354 PubMedID DOI Original Paper URL Indexing Status Subject indexing assigned by NLM MeSH Chronic Pain /therapy; Databases, Bibliographic /statistics & Humans; Musculoskeletal Pain /psychology /therapy; Outcome Assessment (Health Care); Patient Education as Topic /methods; Psychotherapy; Randomized Controlled Trials as Topic (...) -management interventions for chronic musculoskeletal pain. Searching Seven electronic databases (including MEDLINE, EMBASE and The Cochrane Library) were searched between 1994 and April 2009. Searches were restricted to peer reviewed published English language articles; search terms were reported. In addition, reference lists of relevant reviews were manually searched. Study selection Eligible for inclusion were randomised controlled trials (RCTs) that compared the effectiveness of multi-component self

2013 DARE.

39. Pain Relief Intervention of Meditation in Renal Disease (PRIMER)

Pain Relief Intervention of Meditation in Renal Disease (PRIMER) Pain Relief Intervention of Meditation in Renal Disease (PRIMER) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Pain Relief Intervention (...) Purpose: Supportive Care Official Title: Pain Relief Intervention of Meditation in Renal Disease Actual Study Start Date : April 24, 2015 Actual Primary Completion Date : June 30, 2017 Actual Study Completion Date : June 30, 2017 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Intervention The intervention consists of 8-10 sessions consisting of mindfulness-based stress reduction. Key components of what

2017 Clinical Trials

40. The effect of local/topical analgesics on incisional pain in a pig model Full Text available with Trip Pro

The effect of local/topical analgesics on incisional pain in a pig model Interest in the development of new topical/local drug administration for blocking pain at peripheral sites, with maximum drug activity and minimal systemic effects, is on the rise. In the review article by Kopsky and Stahl, four critical barriers in the process of research and development of topical analgesics were indicated. The active pharmaceutical ingredient (API) and the formulation are among the major challenges (...) previously shown that pigs are comparable to humans in ways that make them a better choice for evaluating topical and local analgesics. The aim of this study was to summarize several experiments that used pigs for testing postoperative pain in an incisional pain model (skin incision [SI] and skin and muscle incision [SMI]). At the end of the surgery, the animals were treated with different doses of bupivacaine solution (Marcaine®), bupivacaine liposomal formulation (Exparel®) or ropivacaine solution

2017 Journal of pain research

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>