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Topical Analgesic

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21. Topical Anti‐Inflammatory and Analgesic Effects of Multiple Applications of S(+)‐Flurbiprofen Plaster (SFPP) in a Rat Adjuvant‐Induced Arthritis Model (PubMed)

Topical Anti‐Inflammatory and Analgesic Effects of Multiple Applications of S(+)‐Flurbiprofen Plaster (SFPP) in a Rat Adjuvant‐Induced Arthritis Model Preclinical Research The aim of this study was to evaluate the efficacy of multiple applications of S(+)-flurbiprofen plaster (SFPP), a novel Nonsteroidal anti-inflammatory drug (NSAID) patch, for the alleviation of inflammatory pain and edema in rat adjuvant-induced arthritis (AIA) model as compared to other NSAID patches. The AIA model (...) applications of SFPP exerted a significant analgesic effect from the first day of application as compared to the other NSAID patches. In terms of paw edema, SFPP decreased edema from the second day after application, Multiple applications of SFPP were superior to those of other NSAID patches, in terms of the analgesic effect with multiple applications. These results suggest that SFPP may be a beneficial patch for providing analgesic and anti-inflammatory effects clinically. Drug Dev Res 77 : 206-211, 2016

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2016 Drug development research

22. Intramuscular versus Intravenous Administration of Analgesics and Sedatives: Comparative Clinical Effectiveness and Guidelines

, intramuscular, other miscellaneous topics, Hospital, Acute care, Intravenous, Injections, Injection, intramuscularly, Intramuscular, Sedative, sedatives, Analgesics, Analgesic, Analgesia Files Rapid Response Summary of Abstracts Published : March 3, 2017 Follow us: © 2019 Canadian Agency for Drugs and Technologies in Health Get our newsletter: (...) Intramuscular versus Intravenous Administration of Analgesics and Sedatives: Comparative Clinical Effectiveness and Guidelines Intramuscular versus Intravenous Administration of Analgesics and Sedatives: Comparative Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Intramuscular versus Intravenous Administration of Analgesics and Sedatives: Comparative Clinical Effectiveness and Guidelines Intramuscular versus Intravenous Administration of Analgesics and Sedatives

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

23. Are Topical Nonsteroidal Anti-Inflammatory Drugs Useful for Analgesia in Patients With Traumatic Corneal Abrasions?

, , and the World Health Organization International Clinical Trials Registry Platform in March 2017. Study Selection Studies were included if they were randomized controlled trials comparing topical nonsteroidal anti-inflammatory drugs with placebo or any alternative analgesic in adults with corneal abrasions. The primary outcomes were patient-reported pain reduction greater than 30% or more and 50% or more after 24 hours. The secondary outcomes of the review included the use of rescue analgesia after 24 hours (...) with a random-effects model unless there were 3 or fewer trials for the outcome. Heterogeneity for the appropriateness of pooling data was assessed with the I 2 statistic. Results Topical nonsteroidal anti-inflammatory drugs versus placebo or standard of care to reduce the use of rescue oral analgesics at 24 hours or complications. Study No. of Studies (Patients) Risk Ratio (95% CI) I 2 , % Need for rescue analgesia at 24 h 4 (481) 0.46 (0.34–0.61) 0 Complications 6 (609) 0.44 (0.07–2.96) 0 CI , Confidence

2019 Annals of Emergency Medicine Systematic Review Snapshots

24. British Association of Dermatologists and British photodermatology Group guidelines for topical photodynamic therapy

, are associ- ated with the likelihood of higher levels of pain than smaller lesions or ?elds on nonhead and neck sites. Methods of pain relief such as topical analgesics and anaesthetics, cold air and pausing irradiation have little or limited impact on minimiz- ing the pain experienced, although nerve blockade may be more effective. The introduction of PDT with lower- © 2018 British Association of Dermatologists British Journal of Dermatology (2018) BAD and BPG guidelines for topical photodynamic therapy (...) British Association of Dermatologists and British photodermatology Group guidelines for topical photodynamic therapy GUIDELINE BJD British Journal of Dermatology British Association of Dermatologists and British Photodermatology Group guidelines for topical photodynamic therapy 2018 T.H. Wong, 1 C.A. Morton, 1 N. Collier, 2 A. Haylett, 2 S. Ibbotson, 3 K.E. McKenna, 4 R. Mallipeddi, 5 H. Moseley, 3 D.C. Seukeran, 6 L.E. Rhodes, 2 K.A. Ward, 7 M.F. Mohd Mustapa 8 and L.S. Exton 8 1 Stirling

2019 British Association of Dermatologists

25. Nonopioid, Over-the-Counter Analgesics Can Be as or More Effective Than Prescription Medications Containing Opioids in the Pain Management of Post-Extraction Patients

Nonopioid, Over-the-Counter Analgesics Can Be as or More Effective Than Prescription Medications Containing Opioids in the Pain Management of Post-Extraction Patients UTCAT3212, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Nonopioid, Over-the-Counter Analgesics Can Be as or More Effective Than Prescription Medications Containing Opioids in the Pain Management of Post-Extraction Patients Clinical Question For a post (...) -extraction patient, are over-the-counter pain medications as effective in pain relief as opioids? Clinical Bottom Line Non-opioid, over-the-counter analgesics can be as, or more, effective than prescription pain medications containing opioids. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Daniels/2011 678 Extraction patients with impacted third molars Randomized Controlled Trial Key results “1 or 2 tablets

2017 UTHSCSA Dental School CAT Library

26. Topical non-steroidal anti-inflammatory drugs for analgesia in traumatic corneal abrasions. (PubMed)

of topical NSAIDs with placebo or any alternative analgesic interventions in adults with traumatic corneal abrasions (including corneal abrasions arising from foreign body removal), to reduce pain, and its effects on healing time.We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials Register) (2017, Issue 2), MEDLINE Ovid (1946 to 30 March 2017), Embase Ovid (1947 to 30 March 2017), LILACS (Latin American and Caribbean Health Sciences (...) in the electronic searches for trials.We checked the reference lists of identified trials to search for further potentially relevant studies.RCTs comparing topical NSAIDs to placebo or any alternative analgesic interventions in adults with traumatic corneal abrasions.Two review authors independently performed data extraction and assessed risks of bias in the included studies. We rated the certainty of the evidence using GRADE.We included nine studies that met the inclusion criteria, reporting data on 637

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2017 Cochrane

27. Topical anaesthetics for pain control during repair of dermal laceration. (PubMed)

.To assess whether benefits of non-invasive topical anaesthetic application occur at the expense of decreased analgesic efficacy. To compare the efficacy of various single-component or multi-component topical anaesthetic agents for repair of dermal lacerations. To determine the clinical necessity for topical application of the ester anaesthetic, cocaine.For this updated review, we searched the following databases: Cochrane Central Register of Controlled Trials (CENTRAL; 2016, Issue 11), Cumulative Index (...) (CI) 2.16 to 13.35). Most trials that compared infiltrated and topical anaesthetics were at high risk of bias, which is likely to have affected their results. Researchers found that several cocaine-free topical anaesthetics provided effective analgesic efficacy. However, data regarding the efficacy of each topical agent are based mostly on single comparisons in trials with unclear or high risk of bias. Mild, self-limited erythematous skin induration occurred in one of 1042 participants who had

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2017 Cochrane

28. Postpartum Analgesic Management of Patients at Risk for Prolonged Pain and Analgesic Use

will be used by the research pharmacy and study drug will be prepared in numbered bottles. Primary Purpose: Treatment Official Title: Postpartum Analgesic Management of Patients at Risk for Prolonged Pain and Analgesic Use Actual Study Start Date : September 17, 2018 Estimated Primary Completion Date : March 31, 2021 Estimated Study Completion Date : March 31, 2021 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention (...) Postpartum Analgesic Management of Patients at Risk for Prolonged Pain and Analgesic Use Postpartum Analgesic Management of Patients at Risk for Prolonged Pain and Analgesic Use - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2018 Clinical Trials

29. Prescribing for rheumatological conditions in pregnancy and breastfeeding - Part II: analgesics and other drugs used in rheumatology practice.

Prescribing for rheumatological conditions in pregnancy and breastfeeding - Part II: analgesics and other drugs used in rheumatology practice. We use cookies to enhance your experience on our website. By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time. BSR and BHPR guideline on prescribing drugs in pregnancy and breastfeeding—Part II: analgesics and other drugs used in rheumatology practice | Rheumatology | Oxford Academic (...) Search Account Menu Menu Navbar Search Filter Mobile Microsite Search Term Close search filter search input Article Navigation Close mobile search navigation Article navigation September 2016 Article Contents Article Navigation BSR and BHPR guideline on prescribing drugs in pregnancy and breastfeeding—Part II: analgesics and other drugs used in rheumatology practice Julia Flint 1 Centre for Rheumatology Research, UCL Division of Medicine, University College London, London, Search for other works

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2016 British Society for Rheumatology

30. Topical Analgesic

Topical Analgesic Topical Analgesic Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Topical Analgesic Topical Analgesic Aka: Topical (...) Analgesic From Related Chapters II. Cost Topical Analgesics are expensive (even for generics) and often not covered by insurance As of 2015, monthly costs may range from $100 patches to >$1500 for Pensaid ( ) Least expensive options 4% patches (e.g. 4%) - OTC III. Preparations : Diclofenac (Pensaid 1.5%) (Voltaren Gel 1.5%) ( ) (5% ) Limited to 12 hour application per day Cost >$100 per 30 generic patches (2015) However, OTC 4% patches (e.g. 4%) cost only $3 per patch Unclear efficacy compared with 5

2016 FP Notebook

31. Intranasal Versus Intravenous Administration of Anxiolytic or Analgesic Medications

Intranasal Versus Intravenous Administration of Anxiolytic or Analgesic Medications TITLE: Intranasal Versus Intravenous Administration of Anxiolytic or Analgesic Medications: Comparative Clinical Effectiveness DATE: 21 January 2014 RESEARCH QUESTIONS 1. What is the clinical effectiveness of intranasal versus intravenous administration of anxiolytic medications in the pre-hospital or emergency setting? 2. What is the clinical effectiveness of intranasal versus intravenous administration (...) of analgesic medications in the pre-hospital or emergency setting? KEY MESSAGE Three systematic reviews, three randomized controlled trials, and one non-randomized study were identified regarding intranasal versus intravenous administration of anxiolytic or analgesic medications in the pre-hospital or emergency setting. METHODS A limited literature search was conducted on key resources including PubMed, The Cochrane Library (2013, Issue 12), University of York Centre for Reviews and Dissemination (CRD

2014 Canadian Agency for Drugs and Technologies in Health - Rapid Review

32. Can topical NSAIDs help relieve the pain of arthritis?

. So, as I (allegedly) said to my young daughters,… …just put some cream on it! Topical preparations of diclofenac and ketoprofen probably give good levels of pain relief in osteoarthritis. It appears, however, that a significant element of their analgesic effect is through the carrier, with the NSAID component a small added bonus. Real food for thought…. Can topical NSAIDs help relieve the pain of arthritis? by is licensed under a . Based on a work at . Permissions beyond the scope of this license (...) Can topical NSAIDs help relieve the pain of arthritis? Can topical NSAIDs help relieve the pain of arthritis? - Evidently Cochrane Search and hit Go By May 6, 2016 // A blog for non-medical readers by Lynda Ware, Senior Fellow in General Practice with Cochrane UK. “Just put some cream on it….” According to my three daughters, this was my stock response to any request they made for motherly intervention when pain struck. Whilst refuting this slur utterly (and the one about not even looking), I

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2016 Evidently Cochrane

33. Can topical NSAIDs help relieve the pain of arthritis?

. So, as I (allegedly) said to my young daughters,… …just put some cream on it! Topical preparations of diclofenac and ketoprofen probably give good levels of pain relief in osteoarthritis. It appears, however, that a significant element of their analgesic effect is through the carrier, with the NSAID component a small added bonus. Real food for thought…. Can topical NSAIDs help relieve the pain of arthritis? by is licensed under a . Based on a work at . Permissions beyond the scope of this license (...) Can topical NSAIDs help relieve the pain of arthritis? Can topical NSAIDs help relieve the pain of arthritis? - Evidently Cochrane Search and hit Go By May 6, 2016 // A blog for non-medical readers by Lynda Ware, Senior Fellow in General Practice with Cochrane UK. “Just put some cream on it….” According to my three daughters, this was my stock response to any request they made for motherly intervention when pain struck. Whilst refuting this slur utterly (and the one about not even looking), I

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2016 Evidently Cochrane

34. Effects of Benzocaine 20% Topical Anesthetic and no Topical Agent on Pain Perception During Intra-oral Injections

Effects of Benzocaine 20% Topical Anesthetic and no Topical Agent on Pain Perception During Intra-oral Injections Effects of Benzocaine 20% Topical Anesthetic and no Topical Agent on Pain Perception During Intra-oral Injections - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Effects of Benzocaine 20% Topical Anesthetic and no Topical Agent on Pain Perception During Intra-oral Injections The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03261115 Recruitment Status : Completed First Posted : August 24, 2017

2017 Clinical Trials

35. Trial Evaluating multimOdal toPical Cream In CompArison to pLacebo (TOPICAL)

: March 20, 2019 Sponsor: University of Michigan Collaborators: McMaster University Oakville Trafalgar Memorial Hospital Information provided by (Responsible Party): Neil Bakshi, University of Michigan Study Details Study Description Go to Brief Summary: Randomized controlled trial regarding the efficacy of a multimodal topical analgesic, Multiprofen, in comparison to placebo cream treatment on knee pain and function in patients with knee osteoarthritis. Condition or disease Intervention/treatment (...) Trial Evaluating multimOdal toPical Cream In CompArison to pLacebo (TOPICAL) Trial Evaluating multimOdal toPical Cream In CompArison to pLacebo (TOPICAL) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2017 Clinical Trials

36. Clinical Study for Comparative Assessment of Efficacy and Safety of Angal S, Topical Spray and ANTI-ANGIN® FORMULA, Topical Metered Spray in Treatment of Patients With Uncomplicated Acute Infectious and Inflammatory Diseases of the Pharynx, Accompanied b

Clinical Study for Comparative Assessment of Efficacy and Safety of Angal S, Topical Spray and ANTI-ANGIN® FORMULA, Topical Metered Spray in Treatment of Patients With Uncomplicated Acute Infectious and Inflammatory Diseases of the Pharynx, Accompanied b Clinical Study for Comparative Assessment of Efficacy and Safety of Angal S, Topical Spray and ANTI-ANGIN® FORMULA, Topical Metered Spray in Treatment of Patients With Uncomplicated Acute Infectious and Inflammatory Diseases of the Pharynx (...) , Accompanied by a Sore Throat - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Clinical Study for Comparative Assessment of Efficacy and Safety of Angal S, Topical Spray and ANTI-ANGIN® FORMULA, Topical Metered Spray

2017 Clinical Trials

37. Topical analgesics in the treatment of knee osteoarthritis: a systematic review and guidelines

Topical analgesics in the treatment of knee osteoarthritis: a systematic review and guidelines Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address (...) screening of the eligible articles for final inclusion. In each phase, 2 observers will independently assess each article. Discrepancies will be resolved through discussion, or by consulting a third investigator. ">Procedure for study selection Example : Title-abstract screening: 1. Not an original full research paper (e.g. review, editorial) 2. Not an in vivo animal study 3. No metastases/ only primary tumor 4. No control group 5. Combination therapy or contamination 6. Not about analgesics used

2018 PROSPERO

38. The Analgesic Activity of a Topical Formulation in Patients With Osteoarthritis of the Hands

The Analgesic Activity of a Topical Formulation in Patients With Osteoarthritis of the Hands The Analgesic Activity of a Topical Formulation in Patients With Osteoarthritis of the Hands - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. The Analgesic Activity of a Topical Formulation in Patients With Osteoarthritis of the Hands The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02485145 Recruitment Status : Unknown Verified June 2015 by Transdermal Therapeutics, Inc.. Recruitment status was: Not yet recruiting

2015 Clinical Trials

39. α-Pinene, linalool, and 1-octanol contribute to the topical anti-inflammatory and analgesic activities of frankincense by inhibiting COX-2. (PubMed)

α-Pinene, linalool, and 1-octanol contribute to the topical anti-inflammatory and analgesic activities of frankincense by inhibiting COX-2. Frankincense oil and water extracts (FOE, FWE) have long been used for external treatment of inflammation and pain. The present study was conducted to identify the active ingredients responsible for the anti-inflammatory and analgesic effects and to determine the underlying mechanisms.The compositions of FOE and FWE were identified and compared by GC-MS (...) and faster lessening of swelling and pain than mice treated with FWE. The combination of the three components had more potent pharmacological effects on hind paw inflammation and COX-2 overexpression than the three components used alone.These findings suggest that topical application of FOE or its active ingredients (including α-pinene, linalool, and 1-octanol) exhibit significantly anti-inflammatory and analgesic effects through inhibiting nociceptive stimulus-induced inflammatory infiltrates and COX-2

2015 Journal of Ethnopharmacology

40. Topical and Intranasal Analgesic Therapy in a Woman with Refractory Postherpetic Neuralgia (PubMed)

Topical and Intranasal Analgesic Therapy in a Woman with Refractory Postherpetic Neuralgia A patient-specific, stepped approach to topical and intranasal analgesic pharmacotherapy was effective in reducing refractory postherpetic neuralgia (PHN) not responding to the current standard of care for PHN. The use of topical analgesic therapy allowed for higher concentrations of medication locally while reducing the likelihood of systemic side effects common to the drugs used. No adverse effects were (...) noted for either topical or intranasal drug therapy. The patient-specific, stepped approach resulted in clinically significant decreases in pain on visual analog scale (VAS), with the use of intranasal ketamine 10% solution and topical gabapentin 6%, ketoprofen 10%, lidocaine 5%, and ketamine 10% cream.

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2015 Case reports in medicine

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