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Topical Analgesic

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181. Temporal disconnection between pain relief and trigeminal nerve microstructural changes after Gamma Knife radiosurgery for trigeminal neuralgia. (Abstract)

Temporal disconnection between pain relief and trigeminal nerve microstructural changes after Gamma Knife radiosurgery for trigeminal neuralgia. Gamma Knife radiosurgery (GKRS) is a noninvasive surgical treatment option for patients with medically refractive classic trigeminal neuralgia (TN). The long-term microstructural consequences of radiosurgery and their association with pain relief remain unclear. To better understand this topic, the authors used diffusion tensor imaging (DTI (...) by DTI metric analyses, contrasting treated and contralateral control nerves to identify specific biomarkers of successful pain relief.GKRS resulted in successful pain relief that was accompanied by asynchronous reductions in fractional anisotropy (FA), which maximized 24 months after treatment. While GKRS responders demonstrated significantly reduced FA within the radiosurgery target 12 and 24 months posttreatment (p < 0.05 and p < 0.01, respectively), nonresponders had statistically

2019 Journal of Neurosurgery

182. Randomised, placebo controlled, double blind trial: Topical lidocaine?epinephrine?tetracaine is effective in reducing pain during laceration repair with tissue adhesive in children

Randomised, placebo controlled, double blind trial: Topical lidocaine?epinephrine?tetracaine is effective in reducing pain during laceration repair with tissue adhesive in children Topical lidocaine–epinephrine–tetracaine is effective in reducing pain during laceration repair with tissue adhesive in children | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn (...) more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Topical lidocaine–epinephrine–tetracaine is effective in reducing pain during

2014 Evidence-Based Nursing

183. Prolonged Multimodal Analgesia for Post-Discharge Pain Control After Primary Total Hip Arthroplasty

Prolonged Multimodal Analgesia for Post-Discharge Pain Control After Primary Total Hip Arthroplasty Prolonged Multimodal Analgesia for Post-Discharge Pain Control After Primary Total Hip Arthroplasty - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) provided PRN oxycodone and tramadol to use on an as needed basis. The third arm will comprise a multimodal pain management protocol, which does not routinely allow for opioid consumption. However, patients will be provided a one week supply of oxycodone and tramadol for emergency pain relief only. Condition or disease Intervention/treatment Phase Osteoarthritis, Hip Drug: Multi-modal with as needed opioids Drug: Multi-modal with one week of opioids offered Drug: Standard of Care Not Applicable Study

2017 Clinical Trials

184. The Comparison of Postoperative Pain After Lumbar Fusion Surgery in Intravenous Patient-controlled Analgesia Between Conventional Mode and Optimizing B.I Mode With 'PAINSTOP' Equipment

The Comparison of Postoperative Pain After Lumbar Fusion Surgery in Intravenous Patient-controlled Analgesia Between Conventional Mode and Optimizing B.I Mode With 'PAINSTOP' Equipment The Comparison of Postoperative Pain After Lumbar Fusion Surgery in Intravenous Patient-controlled Analgesia Between Conventional Mode and Optimizing B.I Mode With 'PAINSTOP' Equipment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration (...) analgesics as well as a patient controlled analgesia (PCA). The most common pain control method of this surgery is the intravenous (IV) PCA. but, if it is relatively insufficient amount of narcotic analgesics ,in the case of IV PCA, may be failed to reduce the pain intensity effectively. Consequently, it may result in the a lot of rescue analgesics requirement, which leads to the adverse effects in patients who are very sensitive to narcotic analgesics. In addition, the patient's satisfaction to the PCA

2017 Clinical Trials

185. The Analgesic Efficacy of the Ultrasound-Guided Femoral Articular Branch Block for Ambulatory Hip Arthroscopy

. This procedure is frequently associated with severe post-operative pain despite the practice of injecting the hip joint with local anesthetics at the end of the procedure and the use of intraoperative opioids. The ideal analgesic technique that provides adequate pain relief following this procedure has not been established yet. There is evidence to suggest that a femoral nerve block (FNB) may provide clinically meaningful analgesia. The investigators have examined the benefits of FNB both retrospectively (...) will be randomized to receive the femoral articular branch block and the other half of patients will be randomized to receive a placebo block. A comparison of pain will be made between both groups. Condition or disease Intervention/treatment Phase Anesthesia, Regional Procedure: Femoral Articular Branch Block Procedure: Placebo Block Not Applicable Detailed Description: Hip arthroscopy is a surgical technique that is gaining popularity for its diagnostic and therapeutic role in the management of adult hip pain

2017 Clinical Trials

186. the Effect of Three Different Analgesic Techniques on the Incidence of Postoperative Nausea and Vomiting

been used intraoperatively to decrease the incidence and severity of the OCR and to prevent pain and PONV after strabismus surgery and vitrectomy without scleral buckling . The current study was designed to compare the effect of three different analgesic techniques ; IV analgesia , peribulbar block and topical xylocaine jel on the incidence of ponv after scleral buckling under general anesthesia. Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment (...) the Effect of Three Different Analgesic Techniques on the Incidence of Postoperative Nausea and Vomiting the Effect of Three Different Analgesic Techniques on the Incidence of Postoperative Nausea and Vomiting - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2017 Clinical Trials

187. A Comparison of Analgesic Efficacy of Ultrasound-Guided Genicular Nerve Block Versus Saline Injection for Total Knee Replacement

, Randomized Controlled Trial Actual Study Start Date : October 5, 2017 Estimated Primary Completion Date : October 5, 2019 Estimated Study Completion Date : October 5, 2020 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Group 1 Patient will receive genicular nerve block with bupivacaine Drug: bupivacaine Group 1 will receive genicular nerve block using bupivacaine Placebo Comparator (...) A Comparison of Analgesic Efficacy of Ultrasound-Guided Genicular Nerve Block Versus Saline Injection for Total Knee Replacement A Comparison of Analgesic Efficacy of Ultrasound-Guided Genicular Nerve Block Versus Saline Injection for Total Knee Replacement - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have

2017 Clinical Trials

188. Review of Post-Marketing Safety Data on Tapentadol, a Centrally Acting Analgesic Full Text available with Trip Pro

Review of Post-Marketing Safety Data on Tapentadol, a Centrally Acting Analgesic Tapentadol is a centrally acting analgesic that has been available for the management of acute and chronic pain in routine clinical practice since 2009.This is the first integrated descriptive analysis of post-marketing safety data following the use of tapentadol in a broad range of pain conditions relating to the topics overall safety, dose administration above approved dosages, administration during pregnancy (...) , serotonin syndrome, respiratory depression, and convulsion. The data analyzed pertain to spontaneous reports from healthcare and non-healthcare professionals and were put in the context of safety information known from interventional and non-interventional trials.The first years of routine clinical practice experience with tapentadol have confirmed the tolerability profile that emerged from the clinical trials. Moreover, the reporting of expected side effects such as respiratory depression

2017 Advances in therapy

189. Academic detailers' and general practitioners' views and experiences of their academic detailing visits to improve the quality of analgesic use: process evaluation alongside a pragmatic cluster randomized controlled trial. Full Text available with Trip Pro

Academic detailers' and general practitioners' views and experiences of their academic detailing visits to improve the quality of analgesic use: process evaluation alongside a pragmatic cluster randomized controlled trial. Continuous medical education strategies, including academic detailing (AD), have mixed effects on the quality of prescribing in general practice. Alongside a cluster-randomized controlled trial (cRCT) to assess the effectiveness of AD visits (on appropriate prescribing (...) of analgesics for chronic pain in osteoarthritis) by Farmaka, an independent drug information center, we performed a process evaluation to identify possible barriers and success factors to improve these AD visits, both from the perspective of the academic detailers delivering the visits and the general practitioners (GPs) receiving them.We performed semi-structured interviews with 20 GPs who participated in the cRCT and 13 academic detailers. The interviews were transcribed verbatim and analysed using

2017 BMC health services research

190. Effects of Analgesics in Cesarean Section Elective

Effects of Analgesics in Cesarean Section Elective Effects of Analgesics in Cesarean Section Elective - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effects of Analgesics in Cesarean Section Elective (CES (...) shown to decrease postoperative pain, but we try to check if one brings more benefit than the other. Condition or disease Intervention/treatment Phase Anesthesia; Functional Drug: Hyperbaric bupivacaine+Sufentanil Drug: Hyperbaric bupivacaine+Morphine Phase 4 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 66 participants Allocation: Randomized Intervention Model: Parallel Assignment Intervention Model Description

2017 Clinical Trials

191. Safety, Tolerability, PK, and Analgesic Effect of INL-001 in Children Following Open Inguinal Hernia Repair

Safety, Tolerability, PK, and Analgesic Effect of INL-001 in Children Following Open Inguinal Hernia Repair Safety, Tolerability, PK, and Analgesic Effect of INL-001 in Children Following Open Inguinal Hernia Repair - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) years) and will continue in a step-wise fashion until appropriate doses are established for all 3 pediatric age groups (12 to <17 years, 6 to <12 years, 2 to <6 years). Condition or disease Intervention/treatment Phase Inguinal Hernia Postoperative Pain Drug: Bupivacaine HCl collagen-matrix implant Drug: Bupivacaine HCl infiltration Phase 2 Phase 3 Detailed Description: This is a multicenter, single-dose study in children 12 to <17 years of age, 6 to <12 years of age, 2 to <6 years of age who

2017 Clinical Trials

192. Pupillary Dilation Reflex Assessment for Intraoperative Analgesic Titration.

: October 15, 2018 See Sponsor: University Hospital, Antwerp Collaborator: Universiteit Antwerpen Information provided by (Responsible Party): Davina Wildemeersch, University Hospital, Antwerp Study Details Study Description Go to Brief Summary: In this double blinded randomized controlled study, the pupillary dilation reflex is used for as a nociceptive indicator for opioid administration during elective surgery under general anesthesia. Condition or disease Intervention/treatment Phase Pain, Acute (...) Pupillary Dilation Reflex Assessment for Intraoperative Analgesic Titration. Pupillary Dilation Reflex Assessment for Intraoperative Analgesic Titration. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2017 Clinical Trials

193. Methoxyflurane vs Standard Analgesic Treatment for Trauma Pain in Spanish Emergency Units

. It is inhaled as a vapour at low (sub-anaesthetic) concentrations to achieve an analgesic effect for the management of pain. In Europe countries, where methoxyflurane is already marketed, it is indicated for emergency relief of moderate to severe pain in conscious adult patients with trauma and associated pain. On the other hand, current clinical practice includes a variety of analgesic agents, with the choice of which to employ based on consideration of the risk-benefit factors of each class of drug (...) (SoC) of the hospital, for emergency relief of trauma and associated pain. Any kind of analgesia administered by any route will be valid. Only administration of one analgesic (or fixed combinations) at baseline will considered SoC. Other required analgesics will be considered rescue medication. Drug: Standard of care Any kind of analgesia, administered by any route for emergency relief of moderate to severe pain in conscious adult patients with trauma and associated pain Other Name: No other

2017 Clinical Trials

194. Analgesic Value of Adductor Canal vs Femoral Block After Total Knee Arthroplasty

look identical to blinded investigator and assessor. Primary Purpose: Treatment Official Title: Evaluation of the Comparative Analgesic Value of Adductor Canal Block Versus Femoral Block Following Total Knee Arthroplasty Actual Study Start Date : March 27, 2016 Actual Primary Completion Date : October 19, 2016 Actual Study Completion Date : October 19, 2016 Resource links provided by the National Library of Medicine related topics: related topics: available for: Arms and Interventions Go to Arm (...) Analgesic Value of Adductor Canal vs Femoral Block After Total Knee Arthroplasty Analgesic Value of Adductor Canal vs Femoral Block After Total Knee Arthroplasty - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2017 Clinical Trials

195. Intraoperative Low-dose Ketamine Infusion as the Main Analgesic in Burn Patients

the amount of time to the first narcotic given in the recovery room or ICU, and whether pain scores for awake patients will be lower post-operatively. Condition or disease Intervention/treatment Phase Burns Drug: Ketamine Drug: Sodium chloride Phase 4 Detailed Description: Burn patients suffer from several types of pain (due to stimulation of mechanoreceptors, nociceptors, and chemical stimulation) as well as other injuries. Multiple agents are used to control pain in this special group. Due to different (...) period of time. Opioids have many side effects such as respiratory depression, nausea, vomiting, itching, urinary retention, and hyperalgesia. The latter is of concern in any patient on chronic opioids, including burn patients. Ketamine is a non-competitive N-methyl-D-aspartate (NMDA) antagonist that has been successfully used in burn intensive care units (BICUs) to provide pain for dressing changes. It also has been in use in BICUs to supplement the analgesic effect of opioids. Ketamine exerts its

2017 Clinical Trials

196. A Study to Assess the Analgesic Efficacy and Safety of ASP0819 in Patients With Fibromyalgia

the Analgesic Efficacy and Safety of ASP0819 in Patients With Fibromyalgia Actual Study Start Date : March 20, 2017 Actual Primary Completion Date : February 27, 2018 Actual Study Completion Date : February 27, 2018 Resource links provided by the National Library of Medicine related topics: related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: ASP0819 A single oral dose to be taken preferably in the morning with or without food Drug: ASP0819 oral Placebo Comparator: Placebo (...) A Study to Assess the Analgesic Efficacy and Safety of ASP0819 in Patients With Fibromyalgia A Study to Assess the Analgesic Efficacy and Safety of ASP0819 in Patients With Fibromyalgia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2017 Clinical Trials

197. A Study to Evaluate the Analgesic Efficacy and Safety of V120083 in Subjects With Osteoarthritis (OA) of the Knee

Results First Posted : November 15, 2018 Last Update Posted : February 12, 2019 Sponsor: Purdue Pharma LP Collaborator: Shionogi Information provided by (Responsible Party): Purdue Pharma LP Study Details Study Description Go to Brief Summary: The purpose of this study is to evaluate the analgesic efficacy of V120083 twice daily compared to placebo in subjects with moderate to severe chronic pain due to OA of the knee. Condition or disease Intervention/treatment Phase Osteo Arthritis Knee Drug (...) : V120083 Drug: Naproxen Drug: Placebo Phase 2 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 291 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Participant, Investigator) Primary Purpose: Treatment Official Title: A Phase 2a, Multicenter, Randomized, Double-blind, Placebo-controlled and Active-controlled, Parallel-group Study Evaluating the Analgesic Efficacy and Safety of V120083

2017 Clinical Trials

198. Analgesic Current Therapies for Chronic Neck Pain

the use of analgesic current therapies increase the effectiveness of neck stabilization exercises for improving pain, disability, mood, and quality of life in chronic neck pain? a randomized, controlled, single-blind study Condition or disease Intervention/treatment Phase Chronic Neck Pain Other: Neck stabilization exercise Other: TENS Other: IFC Not Applicable Detailed Description: Analgesic therapies; such as interferential current (IFC) and transcutaneous electrical nerve stimulation (TENS) have (...) information Study Type : Interventional (Clinical Trial) Actual Enrollment : 81 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Outcomes Assessor) Primary Purpose: Supportive Care Official Title: Does The Use Of Analgesic Current Therapies Increase The Effectiveness Of Neck Stabilization Exercises For Improving Pain, Disability, Mood, And Quality Of Life In Chronic Neck Pain? A Randomized, Controlled, Single-Blind Study Actual Study Start Date : October 1, 2015

2017 Clinical Trials

199. Analgesic Effects of Transversus Thoracic Plane (TTP) Block in Cardiac Surgery

: Analgesic Effects of Transversus Thoracic Plane (TTP) Block in Cardiac Surgery - Pilot Study Estimated Study Start Date : October 1, 2017 Estimated Primary Completion Date : May 1, 2018 Estimated Study Completion Date : May 1, 2018 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: The nerve block group TTP block under dynamic ultrasound guidance plus the standard care (hydromorphone, fentanyl (...) Analgesic Effects of Transversus Thoracic Plane (TTP) Block in Cardiac Surgery Analgesic Effects of Transversus Thoracic Plane (TTP) Block in Cardiac Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2017 Clinical Trials

200. A Study to Assess the Analgesic Efficacy and Safety of ASP8062 in Subjects With Fibromyalgia

relative to placebo. Condition or disease Intervention/treatment Phase Fibromyalgia Drug: ASP8062 Drug: Placebo Phase 2 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 183 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Participant, Investigator) Primary Purpose: Treatment Official Title: A Phase 2a, Randomized, Double-Blind Placebo-controlled, Parallel-group Study to Assess the Analgesic (...) A Study to Assess the Analgesic Efficacy and Safety of ASP8062 in Subjects With Fibromyalgia A Study to Assess the Analgesic Efficacy and Safety of ASP8062 in Subjects With Fibromyalgia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2017 Clinical Trials

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