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Topical Analgesic

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1. Topical analgesics for acute and chronic pain in adults - an overview of Cochrane Reviews. Full Text available with Trip Pro

rubefacients, capsaicin, and lidocaine) applied to intact skin for the treatment of acute and chronic pain in adults.We identified systematic reviews in acute and chronic pain published to February 2017 in the Cochrane Database of Systematic Reviews (the Cochrane Library). The primary outcome was at least 50% pain relief (participant-reported) at an appropriate duration. We extracted the number needed to treat for one additional beneficial outcome (NNT) for efficacy outcomes for each topical analgesic (...) Topical analgesics for acute and chronic pain in adults - an overview of Cochrane Reviews. Topical analgesic drugs are used for a variety of painful conditions. Some are acute, typically strains or sprains, tendinopathy, or muscle aches. Others are chronic, typically osteoarthritis of hand or knee, or neuropathic pain.To provide an overview of the analgesic efficacy and associated adverse events of topical analgesics (primarily nonsteroidal anti-inflammatory drugs (NSAIDs), salicylate

2017 Cochrane

2. Nonopioid, Over-the-Counter Analgesics Can Be as or More Effective Than Prescription Medications Containing Opioids in the Pain Management of Post-Extraction Patients

Nonopioid, Over-the-Counter Analgesics Can Be as or More Effective Than Prescription Medications Containing Opioids in the Pain Management of Post-Extraction Patients UTCAT3212, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Nonopioid, Over-the-Counter Analgesics Can Be as or More Effective Than Prescription Medications Containing Opioids in the Pain Management of Post-Extraction Patients Clinical Question For a post (...) -extraction patient, are over-the-counter pain medications as effective in pain relief as opioids? Clinical Bottom Line Non-opioid, over-the-counter analgesics can be as, or more, effective than prescription pain medications containing opioids. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Daniels/2011 678 Extraction patients with impacted third molars Randomized Controlled Trial Key results “1 or 2 tablets

2017 UTHSCSA Dental School CAT Library

3. Postpartum Analgesic Management of Patients at Risk for Prolonged Pain and Analgesic Use

will be used by the research pharmacy and study drug will be prepared in numbered bottles. Primary Purpose: Treatment Official Title: Postpartum Analgesic Management of Patients at Risk for Prolonged Pain and Analgesic Use Actual Study Start Date : September 17, 2018 Estimated Primary Completion Date : March 31, 2021 Estimated Study Completion Date : March 31, 2021 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention (...) Postpartum Analgesic Management of Patients at Risk for Prolonged Pain and Analgesic Use Postpartum Analgesic Management of Patients at Risk for Prolonged Pain and Analgesic Use - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2018 Clinical Trials

4. Evaluation of the effect of topical chamomile (Matricaria chamomilla L.) oleogel as pain relief in migraine without aura: a randomized, double-blind, placebo-controlled, crossover study. (Abstract)

Evaluation of the effect of topical chamomile (Matricaria chamomilla L.) oleogel as pain relief in migraine without aura: a randomized, double-blind, placebo-controlled, crossover study. Phytotherapy is a source of finding new remedies for migraine. Traditional chamomile oil (chamomile extraction in sesame oil) is a formulation in Persian medicine (PM) for pain relief in migraine. An oleogel preparation of reformulated traditional chamomile oil was prepared and then standardized based (...) , vomiting, photophobia, and phonophobia were also monitored. There was 4.48 ± 0.01 μl/ml of chamazulene and 0.233 mg/g of apigenin in the preparation (by correcting the amount with extraction ratio). Thirty-eight patients in the drug-placebo and 34 patients in the placebo-drug groups (a total number of 72 patients as per protocol) completed the process in the randomized controlled trial (RCT). Adapted results from the questionnaires showed that pain, nausea, vomiting, photophobia, and phonophobia

2018 Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology Controlled trial quality: uncertain

5. Effectiveness of a hospital-based postnatal parent education intervention about pain management during infant vaccination: a randomized controlled trial Full Text available with Trip Pro

Effectiveness of a hospital-based postnatal parent education intervention about pain management during infant vaccination: a randomized controlled trial Parents have reported that they want to learn how to reduce pain in infants during vaccinations. Our objective was to compare different levels of intensity of postnatal education about pain mitigation on parental self-reported use of interventions at future infant vaccinations.We conducted a longitudinal, 3-group parallel, add-on, randomized (...) controlled trial on the postnatal ward of a hospital. New mothers, unaware of the hypothesis, were randomly assigned to 1 of 3 intervention groups and 3 follow-up groups (i.e., 9 groups, 3 × 3). The 3 intervention groups were control (general immunization information), pain pamphlet (pain mitigation information), and pain pamphlet and pain video (pain mitigation information). Both pain mitigation education groups also received general immunization information. The 3 follow-up groups were 2-, 4- and 6

2018 CMAJ : Canadian Medical Association Journal Controlled trial quality: uncertain

6. Randomised controlled trial evaluating the short-term analgesic effect of topical diclofenac on chronic Achilles tendon pain: a pilot study. Full Text available with Trip Pro

Randomised controlled trial evaluating the short-term analgesic effect of topical diclofenac on chronic Achilles tendon pain: a pilot study. To determine if a topically applied non-steroidal anti-inflammatory drug (diclofenac) can provide short-term pain relief for chronic Achilles tendinopathy (CAT), in order to inform the development of a new rehabilitation protocol.Pilot double-blind, cross-over randomised controlled trial providing participants with tertiary care. The study was conducted (...) at a single research centre in Vancouver, BC.Sixteen adults with unilateral CAT and three adults with bilateral CAT participated.Participants received two successive treatments (10% diclofenac gel or placebo gel) in random order over a 3-day period. There was a 1-week washout period between the treatments. Allocation was by simple randomisation, and the participants as well as the assessing/treating researcher were blinded to treatment allocation.The primary outcome measure was pain level (0-10) during

2017 BMJ open Controlled trial quality: predicted high

7. Changes in pain and concurrent pain medication use following compounded topical analgesic treatment for chronic pain: 3- and 6-month follow-up results from the prospective, observational Optimizing Patient Experience and Response to Topical Analgesics stu Full Text available with Trip Pro

Changes in pain and concurrent pain medication use following compounded topical analgesic treatment for chronic pain: 3- and 6-month follow-up results from the prospective, observational Optimizing Patient Experience and Response to Topical Analgesics stu Opioids and other controlled substances prescribed for chronic pain are associated with abuse, addiction, and death, prompting national initiatives to identify safe and effective pain management strategies including topical analgesics.This (...) prospective, observational study evaluated changes from baseline in overall mean severity and interference scores on the Brief Pain Inventory scale and the use of concurrent pain medications at 3- and 6-month follow-up assessments in chronic pain patients treated with topical analgesics. Changes in pain severity and interference and medication usage were compared between treated patients and unmatched and matched controls.The unmatched intervention group (unmatched-IG) included 631 patients who completed

2017 Journal of pain research

8. [Evaluation of protocols on the use of analgesics for pain management in patients with extracorporeal shock wave lithotripsy (ESWL)]. (Abstract)

[Evaluation of protocols on the use of analgesics for pain management in patients with extracorporeal shock wave lithotripsy (ESWL)]. Extracorporeal shock wave lithotripsy-related pain is the largest limiting factor in this technique. Our study aimed to compare the effectiveness of different types of analgesics for pain management used during ESWL sessions. We conducted a prospective study of 300 patients with urinary lithiasis justifying ESWL treatment. The patients were randomized to three (...) groups: group I, included 100 patients who received intramuscular injection of 2cc of physiological saline solution (placebo), group II included 100 patients who received intramuscular injection of ketoprofen 100mg while group III included 100 patients who received lidocaine and prilocaine topical cream. Visual Analog Scale (VAS) was used to assess pain 10 minutes after and at the end of the session. Mean VAS score 10 minutes after and at the end of ESWL session was 3.7 and 4.91 respectively

2019 The Pan African medical journal Controlled trial quality: uncertain

9. Use of Topical Lidocaine Gel Plus Paracervical Blockade vs. Paracervical Blockade Alone for Pain Management During Manual Vacuum Aspiration: ADouble-Blind, Randomized, Placebo-Controlled Trial. (Abstract)

Use of Topical Lidocaine Gel Plus Paracervical Blockade vs. Paracervical Blockade Alone for Pain Management During Manual Vacuum Aspiration: ADouble-Blind, Randomized, Placebo-Controlled Trial. To evaluate if the use of lidocaine gel applied to the cervix prior to manual vacuum aspiration (MVA) in addition to paracervical blockade is useful in reducing the level of pain associated with the procedure.A total of 88 patients were randomized to receive either 5 mL of lidocaine gel or a placebo (...) applied topically to the cervix 5 minutes prior to paracervical blockade. Both groups received the same drugs for pain control (tramadol hydrochloride, diazepam, and sodium diclofenac). A visual analogue scale (VAS) was used for evaluation of pain intensity at two times: 2 minutes before the blockade (directly after tenaculum clamping of the anterior aspect of the cervix) and after MVA of the uterine cavity.There was a statistically significant difference in pain intensity between the arms

2019 Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC Controlled trial quality: uncertain

10. Effect of Mobile Device-Assisted N-of-1 Trial Participation on Analgesic Prescribing for Chronic Pain: Randomized Controlled Trial. (Abstract)

Effect of Mobile Device-Assisted N-of-1 Trial Participation on Analgesic Prescribing for Chronic Pain: Randomized Controlled Trial. Opioids and non-steroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed for chronic musculoskeletal pain, despite limited evidence of effectiveness and well-documented adverse effects. We assessed the effects of participating in a structured, personalized self-experiment ("N-of-1 trial") on analgesic prescribing in patients with chronic musculoskeletal (...) , p = 0.17). There was a significant reduction in the proportion of patients in the N-of-1 group prescribed NSAIDs compared with control (relative odds ratio = 0.53; 95% CI = 0.29 to 0.96, p = 0.04), with no concomitant increase in average pain intensity. There was no significant change in use of adjunctive medications (acetaminophen, gabapentenoids, or topicals).These exploratory results suggest that participation in N-of-1 trials may reduce long-term use of NSAIDs; there is also a weak signal

2019 Journal of General Internal Medicine Controlled trial quality: predicted high

11. A Topical Anesthetic and Lidocaine Mixture for Pain Relief During Keloid Treatment: A Double-Blind, Randomized Controlled Trial. (Abstract)

A Topical Anesthetic and Lidocaine Mixture for Pain Relief During Keloid Treatment: A Double-Blind, Randomized Controlled Trial. Keloids are abnormal overgrowth of collagen fibers, and the first-line treatment includes intralesional injection of triamcinolone acetonide (TA), which is associated with pain.To study the benefit of applying topical anesthetics or a 1:1 mixture of 1% lidocaine and TA at the TA injection site to alleviate pain during keloid treatment.A double-blind, randomized (...) controlled trial was conducted. Four TA injection methods were tested: control, lidocaine, topical, and combined. A visual analog scale (VAS) was used to assess needle-stick and injection pain. Data on pain duration after injection were also collected.Forty patients were enrolled (mean age, 37.1 years). The VAS scores of needle-stick pain in the control, lidocaine, topical, and combined groups were 4.18 ± 2.12, 3.82 ± 2.48, 2.03 ± 2.02, and 2.20 ± 1.99, respectively. Pain statistically decreased

2017 Dermatologic Surgery Controlled trial quality: uncertain

12. Managing Chronic Non-Terminal Pain in Adults Including Prescribing Controlled Substances

., NSAIDs, opioids). [1D]* • Opioids and problem use. Monitor patients receiving opioid analgesics for misuse with checks of State registries (PMP) for prescription fills (e.g., in Michigan called MAPS) and random urine comprehensive drug screens by EIA-GCMS. [1ID]* • Referral. Referral to pain management specialist should be considered for failure to achieve treatment goals, intolerance of therapies, need for interventional management, need for multidisciplinary treatment, need for excessive opioid (...) doses, suspicion of addiction, or opioid misuse. [1B]* * Strength of recommendation: I = generally should be performed; II = may be reasonable to perform; III = generally should not be performed. Levels of evidence reflect the best available literature in support of an intervention or test: A=randomized controlled trials; B=controlled trials, no randomization; C=observational trials; D=opinion of expert panel. 2 UMHS Chronic Pain Management Guideline, November 2016 Table 1. Evaluation and Management

2017 University of Michigan Health System

13. Comparative Effectiveness of Analgesics To Reduce Acute Pain in the Prehospital Setting

for hypotension, respiratory depression, and mental status changes. Results. We included 52 randomized controlled trials and 13 observational studies. Due to the absence or insufficiency of prehospital evidence we based conclusions for initial analgesia on indirect evidence from the emergency department setting. As initial analgesics, we found no evidence of a clinically important difference in the change of pain scores with opioids versus ketamine administered primarily intravenously (IV) (low SOE), IV (...) , 8 alternative analgesics have been sought. Nonopioid analgesics, including ketamine, acetaminophen (APAP), nitrous oxide/oxygen and nonsteroidal anti-inflammatory drugs (NSAIDs) (specifically ketorolac and ibuprofen) may provide adequate analgesia. This systematic review assesses the comparative effectiveness and harms of opioids compared to nonopioid analgesics for the prehospital management of acute pain (Figure A). Figure A. Analytic framework Abbreviations: AE=adverse event; KQ=Key Question

2019 Effective Health Care Program (AHRQ)

14. Delayed-Onset Muscle Soreness and Topical Analgesic Alter Corticospinal Excitability of the Biceps Brachii. (Abstract)

the administration of menthol-based topical analgesic, there was a reduction in pain, which was accompanied by increased corticospinal inhibition. (...) Delayed-Onset Muscle Soreness and Topical Analgesic Alter Corticospinal Excitability of the Biceps Brachii. The interactive effect of delayed-onset muscle soreness (DOMS) and a topical analgesic on corticospinal excitability was investigated.Thirty-two participants completed Experiments A (no DOMS) and B (DOMS). For each experiment, participants were randomly assigned to two groups: 1) topical analgesic gel (topical analgesic, n = 8), or 2) placebo gel (placebo, n = 8) group. Before

2019 Medicine and science in sports and exercise Controlled trial quality: uncertain

15. Comparison of analgesic effect of preoperative topical Diclofenac versus Ketorolac on postoperative pain after Corneal Collagen Cross Linkage. Full Text available with Trip Pro

Comparison of analgesic effect of preoperative topical Diclofenac versus Ketorolac on postoperative pain after Corneal Collagen Cross Linkage. To compare post-operative pain relieving effect of topical diclofenac 0.1% versus ketorolac 0.5% in Corneal Collagen Cross Linking (CXL) for patients diagnosed with keratoconus.This randomized controlled trial was carried out for six months from October 2016 to March 2017. We included young patients having keratoconus with k-readings greater than 47D (...) and central corneal thickness more than 400 microns. All the patients received single dose one drop of topical diclofenac 0.1% to (Group-A) and ketorolac 0.5% to (Group-B) 30 minutes in advance of the corneal collagen cross linking (CXL) procedure. The CXL was performed with topical 0.1% riboflavin eye drops in 20% dextran as a photo sensitizer. After 36 hours of the CXL procedure, the postoperative intensity of pain was assessed verbally by patients with the help of visual analog scale (VAS) numbers from

2019 Pakistan Journal Of Medical Sciences Controlled trial quality: uncertain

16. Topical Analgesic Improved or Maintained Ballistic Hip Flexion Range of Motion with Treated and Untreated Legs. (Abstract)

Topical Analgesic Improved or Maintained Ballistic Hip Flexion Range of Motion with Treated and Untreated Legs. Increased stretch tolerance can contribute to improved range of motion (ROM). Since menthol-based topical analgesics (TopAnalg) suppress pain, they may increase stretch thresholds improving ROM. Other modalities such as transcutaneous electrical nerve stimulation and rolling have demonstrated decreased pain sensitivity in the contralateral limb. The purpose of this study

2019 Journal of sports science & medicine Controlled trial quality: uncertain

17. Analgesic effectiveness of topical sevoflurane to perform sharp debridement of painful wounds. (Abstract)

debridement of painful wounds, because it was previously approved by our institutional Pharmacy Regulatory Commission and Medical Management. According to this protocol, pain scores were measured by using a numerical rating scale (from 0 to 10 points) over a 10-hour period. Wound debridement was performed following routine procedures.Medical records from 152 patients were reviewed. Baseline pain was severe (median, 7 points). After topical sevoflurane application, the analgesic effect was rapid (median (...) Analgesic effectiveness of topical sevoflurane to perform sharp debridement of painful wounds. Analgesic topical options to perform wound debridement are scarce. The purpose of this study was to communicate our experience using topical sevoflurane as analgesic for wound debridement.After approval by our institutional review board, medical records were reviewed for those patients who had previously accepted to be treated with off-label topical sevoflurane (1 mL/cm2) as an analgesic for sharp

2019 Journal of Vascular Surgery

18. Are Topical Nonsteroidal Anti-Inflammatory Drugs Useful for Analgesia in Patients With Traumatic Corneal Abrasions? Full Text available with Trip Pro

, , and the World Health Organization International Clinical Trials Registry Platform in March 2017. Study Selection Studies were included if they were randomized controlled trials comparing topical nonsteroidal anti-inflammatory drugs with placebo or any alternative analgesic in adults with corneal abrasions. The primary outcomes were patient-reported pain reduction greater than 30% or more and 50% or more after 24 hours. The secondary outcomes of the review included the use of rescue analgesia after 24 hours (...) | There is no consensus on how analgesia for corneal abrasions should be managed in the ED, and there appears to be no universally accepted approach on the use of topical or oral nonsteroidal anti-inflammatory drugs. x 6 Calder, L., Balasubramanian, S., and Stiell, I. Lack of consensus on corneal abrasion management: results of a national survey. CJEM . 2004 ; 6 : 402–407 | | | This review attempted to study whether there was evidence among the available randomized controlled trials that topical nonsteroidal anti

2019 Annals of Emergency Medicine Systematic Review Snapshots

19. Complementary Management of Chronic Neck and/or Low Back Pain With a Pain Relief Kit

participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Complementary Management of Chronic Neck and/or Low Back Pain With a Multimodal Non-pharmacological Pain Relief Kit Actual Study Start Date : March 1, 2017 Actual Primary Completion Date : May 27, 2018 Actual Study Completion Date : May 30, 2018 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment (...) ) and the third data collection point will take place 3 weeks following baseline data collection (T2). In addition, all participants will provide a daily rating of their pain and documentation of pain management interventions they engaged in from the Pain Relief Kit, over the counter (OTC) treatments &/or treatments prescribed by a health care provider. This will result in a one group repeated measures design in which eligible participants will be provided with a Pain Relief Kit for 3 weeks. Analysis

2017 Clinical Trials

20. Intramuscular versus Intravenous Administration of Analgesics and Sedatives: Comparative Clinical Effectiveness and Guidelines

, intramuscular, other miscellaneous topics, Hospital, Acute care, Intravenous, Injections, Injection, intramuscularly, Intramuscular, Sedative, sedatives, Analgesics, Analgesic, Analgesia Files Rapid Response Summary of Abstracts Published : March 3, 2017 Follow us: © 2019 Canadian Agency for Drugs and Technologies in Health Get our newsletter: (...) in acute care with an existing intravenous access? What are the evidence-based guidelines regarding the route of administration for analgesics and sedatives for patients in acute care? Key Message Four randomized controlled trials, two non-randomized studies, and one evidence-based guideline were identified regarding the route of administration for analgesics and sedatives for patients in acute care. Tags analgesics, catheterization, peripheral, hospitals, hypnotics and sedatives, injections

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

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