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Topical Eye Antibiotic

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1. Randomised controlled trial of topical antibacterial Manuka (Leptospermum species) honey for evaporative dry eye due to meibomian gland dysfunction. Full Text available with Trip Pro

Randomised controlled trial of topical antibacterial Manuka (Leptospermum species) honey for evaporative dry eye due to meibomian gland dysfunction. The aim was to evaluate the efficacy of standardised Manuka (Leptospermum species) antibacterial honey as adjunctive twice daily treatment to conventional therapy (warm compresses, lid massage and preservative-free lubricant), in participants with evaporative dry eye due to moderate to advanced meibomian gland dysfunction.This prospective, open (...) -label study involved 114 participants. After two weeks of conventional therapy participants were randomised to one of three treatment groups: Optimel Antibacterial Manuka Eye Gel (98 per cent Leptospermum species honey) plus conventional therapy (n = 37), Optimel Manuka plus Lubricant Eye Drops (16 per cent Leptospermum species honey) plus conventional therapy (n = 37) and a control (conventional therapy) (n = 40). Clinical evaluations performed at baseline and Week 8 included: symptom scores

2018 Clinical & Experimental Optometry Controlled trial quality: uncertain

2. Antibiotics by injection into the eye can prevent severe infection following cataract surgery

the trials of injections into the eyeball were observational. Topical antibiotics were tested in all the randomised trials. There were no trials allowing a direct comparison of antibiotics injected into the eye against each other. What did it find? Nine observational studies found that endophthalmitis was less common after vancomycin or moxifloxacin antibiotic injections into the eye (17 out of 105,003) compared to no injection (156 out of 236,742), (odds ratio [OR] 0.20, 95% confidence interval [CI (...) and moxifloxacin injected inside the eyeball, or under the conjunctiva, or as antibiotic drops applied to the surface of the eye. The results were assessed as moderate to high quality with a low risk of bias. However they were mostly observational studies and these were assessed using a non-standard scale. The authors analysed the data in separate ways to test the variability in results across the studies. All the trials of injections into the eyeball were observational. Topical antibiotics were tested in all

2019 NIHR Dissemination Centre

3. Use of topical ocular antibiotics in young children: a Scandinavian drug utilization study. Full Text available with Trip Pro

Use of topical ocular antibiotics in young children: a Scandinavian drug utilization study. Acute infectious conjunctivitis is a common disease. While usually self-limiting, children often receive treatment to be accepted back into nursery, day care or school. We aimed to describe trends in the utilization of topical ocular antibiotics in young children aged 0-4 years in Denmark, Norway and Sweden.Using individual-level data from the Danish National Prescription Registry (2000-2015), we (...) -year-olds, respectively), after which it dropped by 37% until 2015. In the aggregated data, a markedly higher use was seen in Denmark (211/1000 children in 2016) compared with Sweden (42) and Norway (151). The decrease from 2010 onwards was observed in all three countries. Chloramphenicol and fusidic acid were the most commonly used topical ocular antibiotics across Scandinavia. Tobramycin was rarely used in Norway and Sweden (≤1/1000 children in 2016) compared with Denmark (24/1000 children

2018 Acta ophthalmologica

4. Topical Eye Antibiotic

Topical Eye Antibiotic Topical Eye Antibiotic Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Topical Eye Antibiotic Topical Eye (...) Antibiotic Aka: Topical Eye Antibiotic , Ophthalmic Antibiotic II. Indications Treatment of infection Prophylaxis in (avoid s due to toxicity risk) Chemical Eye Burn III. Preparations: Most cost effective agents First-line Trimethoprim-Polymyxin B (Polytrim) solution 0.5% ointment Broad-spectrum (Gentak) 0.3% ointment or solution Tobramycin (Tobrex) 0.3% solution (ointment is not generic and is expensive) (Ciloxan) 0.3% ointment or solution (Ocuflox) 0.3% solution IV. Preparations: First-Line general

2018 FP Notebook

5. Corticosteroids - topical (skin), nose, and eyes

these effects within the eyes, where they control inflammation due to allergy, trauma, or infection. Availability Which local (skin, nose and eyes) corticosteroids are available in the UK? Topical Topical Topical corticosteroids are available in different and . Some are also available as compound preparations containing substances such as antibacterials, antifungals, and salicylic acid. The benefit of combining antibacterials or antifungals with a topical corticosteroid is uncertain. However, this does (...) Corticosteroids - topical (skin), nose, and eyes Corticosteroids - topical (skin), nose, and eyes - NICE CKS Share Corticosteroids - topical (skin), nose, and eyes: Summary Corticosteroids are synthetic analogues of the natural hormones that are produced by the adrenal cortex. Local corticosteroids are predominantly glucocorticoids. They have 4 main effects: Anti-inflammatory. Immunosuppressive. Anti-proliferative (anti-mitotic). Vasoconstrictive. Topical corticosteroids exert these effects

2018 NICE Clinical Knowledge Summaries

6. The Effect of Topical Ocular Anesthetic Proparacaine on Conjunctival and Nasal Mucosal Flora in Dry Eye Disease Patients Full Text available with Trip Pro

%) eyes (p < 0.001); however, this rate decreased slightly from 24 (60%) to 20 (50%) eyes in group 2 (p > 0.05). For the nasal cultures, the bacterial culture positivity rate decreased from 80% to 20% and from 75% to 65% in groups 1 (p < 0.001) and 2 (p > 0.05), respectively. Topical ocular anesthetic proparacaine has antibacterial activity in both conjunctival and nasal flora in patients with dry eye disease. (...) The Effect of Topical Ocular Anesthetic Proparacaine on Conjunctival and Nasal Mucosal Flora in Dry Eye Disease Patients The aim of this study was to investigate the effect of topically applied ocular anesthetic proparacaine on conjunctival and nasal bacterial mucosal flora in patients with dry eye disease. A Schirmer test was done with (group 1) and without (group 2) topical anesthetic proparacaine to 40 patients in each group. Conjunctival and nasal cultures were obtained before and 10 min

2018 Journal of clinical medicine

7. Allergic contact dermatitis from topical ophthalmic medications: keep an eye on it! (Abstract)

clinic; all patients with a positive patch-test reaction to eye medication or its ingredient(s) having caused ACD were studied. For each allergen identified, the number of positive test results compared with the total number of those in the total population, as well as trends across three periods, namely 1990-1998, 1999-2007, and 2008-2016 were studied.118 patients (0.7%) presented with positive patch-test results to ingredients of, and/or topical ophthalmic medications. Aminoglycoside antibiotics (...) Allergic contact dermatitis from topical ophthalmic medications: keep an eye on it! Allergic contact dermatitis (ACD) from topical ophthalmic medications is often overlooked.To study the demographic characteristics, lesion locations, and associated medical conditions of the patients with ACD from ophthalmic drugs, and to identify the most common allergenic culprits, as well as trends in frequencies over the years.From January 1990 until December 2016, 16 065 patients were investigated in our

2019 Contact Dermatitis

8. In vitro antimicrobial activity of diacerein on 76 <b>gram-positive cocci isolates from bacterial keratitis patients and an in vivo study of diacerein eye drops on <i>Staphylococcus aureus</i> keratitis in mice</b>. Full Text available with Trip Pro

In vitro antimicrobial activity of diacerein on 76 gram-positive cocci isolates from bacterial keratitis patients and an in vivo study of diacerein eye drops on Staphylococcus aureus keratitis in mice. Bacterial keratitis is an aggressive infectious corneal disease. With the continuing rise in antibiotic resistance and a decline in the discovery of new antibiotics, new antimicrobial drugs are now required. In the present study, we determined the antibacterial activity of diacerein (...) to evaluate antibacterial efficacy of diacerein eye drops in vivo. An in vivo eye irritation study was carried out by a modified Draize test in rabbits. Our in vitro results showed that diacerein possesses satisfactory antibacterial activity against the majority of Gram-positive cocci (60/76), including all 57 tested Staphylococcus and 3 Enterococcus The in vivo experiment showed that diacerein eye drops reduced bacterial load and improved ocular clinical scores after topical administration of diacerein

2019 Antimicrobial Agents and Chemotherapy

9. Evaluation of the bacterial ocular surface microbiome in clinically normal horses before and after treatment with topical neomycin-polymyxin-bacitracin. Full Text available with Trip Pro

of the ocular surface microbiome in healthy horses, and to identify whether there are microbial community changes over time and following topical antibiotic use. One eye of 12 horses was treated 3 times daily for 1 week with neomycin-polymyxin-bacitracin ophthalmic ointment. Contralateral eyes served as untreated controls. The inferior conjunctival fornix of both eyes was sampled at baseline prior to initiating treatment (day 0), after 1 week of treatment (day 7), and 4 weeks after concluding treatment (day (...) in both treatment and control eyes over time. Overall, the major bacterial taxa on the equine ocular surface remained stable over time and following topical antibiotic therapy.

2019 PLoS ONE

10. A randomized controlled trial comparing the efficacy of topical antibiotic steroid combination versus no treatment after fornix-incision strabismus surgery. (Abstract)

A randomized controlled trial comparing the efficacy of topical antibiotic steroid combination versus no treatment after fornix-incision strabismus surgery. To compare comfort and inflammation in patients treated with postoperative topical antibiotic steroids in one eye versus no treatment in the other eye.This prospective, randomized single-masked study included all patients with planned symmetrical strabismus surgery via fornix incision. One eye was randomly assigned to topical postoperative (...) tobramycin-dexamethasone and the other eye was not treated. Patient and parent questionnaires were administered, and two masked observers assessed conjunctival injection over the muscle and wound site.A total of 70 patients completed at least 1 postoperative visit and were included. There was no statistically significant difference between the treatment eye and the no treatment eye in any of the studied parameters.Postoperative topical antibiotic steroid did not prove to be superior to no treatment

2018 JAAPOS - Journal of the American Association for Pediatric Ophthalmology and Strabismus Controlled trial quality: uncertain

11. A diagnosis of late-onset Myasthenia gravis unmasked by topical antibiotics Full Text available with Trip Pro

A diagnosis of late-onset Myasthenia gravis unmasked by topical antibiotics Myasthenia Gravis (MG) is a disorder of the neuromuscular junction (NMJ) that manifests as fluctuating fatiguable weakness of the muscles. There are many factors that can exacerbate myasthenia symptoms including a variety medications and drugs, systemic illness, and pregnancy. A number of medications have been implicated in exacerbating MG symptoms, including aminoglycosides. We present a case of an elderly female (...) with newly diagnosed MG following the use of tobramycin eye drops for 3 days. There have been limited reports in the literature of topical medications that exacerbate MG symptoms. Clinicians prescribing tobramycin eye drops (or other associated medications) should have a high index of suspicion of MG as early discontinuation and therapy will limit long-term morbidity and mortality in these patients.

2018 Journal of community hospital internal medicine perspectives

12. Development of prednisolone-containing eye drop formulations by cyclodextrin complexation and antimicrobial, mucoadhesive biopolymer Full Text available with Trip Pro

Development of prednisolone-containing eye drop formulations by cyclodextrin complexation and antimicrobial, mucoadhesive biopolymer The formulation of topical ophthalmic products with appropriate therapeutic effect and patient compliance is a major challenge. To increase the efficiency of the ocular delivery of the drug, the enhancement of water solubility and the contact time of the drug on the surface of the cornea are necessary. In this work, prednisolone (PR)-containing eye drops were (...) formulated with antimicrobial, mucoadhesive biopolymer and PR-cyclodextrin inclusion complex. This approach can be used for the development of innovative ophthalmic formulations.After adjusting the optimal physiological parameters, the amount of the required cyclodextrin for the highest penetration of PR was determined by dialysis membrane diffusion study. The viscosity, surface tension and mucoadhesion of the eye drops were measured. The microbiological effectiveness of zinc-hyaluronate (ZnHA

2018 Drug design, development and therapy

13. Antibiotics for trachoma. (Abstract)

, and it was difficult to judge risk of bias.There was low-certainty evidence of little or no difference in effect between oral and topical antibiotics on active trachoma at three months (RR 0.97, 95% CI 0.81 to 1.16; 953 people; 6 RCTs; I2 = 63%) and 12 months (RR 0.93, 95% CI 0.75 to 1.15; 886 people; 5 RCTs; I2 = 56%). There was very low-certainty evidence for ocular infection at three or 12 months. Antimicrobial resistance was not assessed. In those studies that reported adverse effects, no serious adverse (...) azithromycin with topical tetracycline. The evidence was inconsistent for active trachoma and ocular infection at three and 12 months (low-certainty evidence) and was not pooled due to considerable heterogeneity. Antimicrobial resistance and adverse effects were not reported.Different dosing strategiesSix studies compared different strategies for dosing. There were: mass treatment at different dosing intervals; applying cessation or stopping rules to mass treatment; strategies to increase mass treatment

2019 Cochrane

14. Antibiotic prescribing - especially broad spectrum antibiotics

Antibiotic prescribing - especially broad spectrum antibiotics Antimicrobial stewardship: prescribing Antimicrobial stewardship: prescribing antibiotics antibiotics Key therapeutic topic Published: 15 January 2015 nice.org.uk/guidance/ktt9 pathways K Ke ey points y points Antimicrobial resistance poses a significant global threat to public health, especially because antimicrobials underpin routine medical practice. Addressing antimicrobial resistance through improving stewardship is a national (...) or moderately severe infections unless other antibacterial medicines commonly recommended for these infections cannot be used. Fluoroquinolone antibiotics should be avoided when treating infections in people who have previously experienced serious adverse events with fluoroquinolones. They should be used with Antimicrobial stewardship: prescribing antibiotics (KTT9) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 5

2015 National Institute for Health and Clinical Excellence - Advice

15. Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery. Full Text available with Trip Pro

outcomes.Multiple measures for preventing endophthalmitis following cataract surgery have been studied. High-certainty evidence shows that injection with cefuroxime with or without topical levofloxacin lowers the chance of endophthalmitis after surgery, and there is moderate-certainty evidence to suggest that using antibiotic eye drops in addition to antibiotic injection probably lowers the chance of endophthalmitis compared with using injections or eye drops alone. Clinical trials with rare outcomes require (...) Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery. Endophthalmitis is a severe inflammation of the anterior or posterior (or both) chambers of the eye that may be sterile or associated with infection. It is a potentially vision-threatening complication of cataract surgery. Prophylactic measures for endophthalmitis are targeted against various sources of infection.To evaluate the effects of perioperative antibiotic prophylaxis for endophthalmitis following

2017 Cochrane

16. Cost comparison of commonly used postoperative topical ophthalmic antibiotics. (Abstract)

Cost comparison of commonly used postoperative topical ophthalmic antibiotics. To provide information on the actual fill level and cost of currently available antibiotic drops used perioperatively.Prospective laboratory investigation.Robert Cizik Eye Clinic, Houston, Texas USA.The following 9 medications were tested: moxifloxacin, gatifloxacin (branded and generic), besifloxacin, levofloxacin, ciprofloxacin, ofloxacin, trimethoprim/polymyxin B, tobramycin, and gentamicin. Actual bottle-fill (...) . The costs of common postoperative topical antibiotic regimens vary widely depending on the drug and dosing regimen. Cost considerations for perioperative antibiotics will be increasingly important because the number of cataract surgeries is expected to increase with the growing and aging population.Copyright © 2017 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

2017 Journal of cataract and refractive surgery

17. Comparison between corneal cross-linking, topical antibiotic and combined therapy in experimental bacterial keratitis model Full Text available with Trip Pro

Comparison between corneal cross-linking, topical antibiotic and combined therapy in experimental bacterial keratitis model This study was conducted to investigate the effects of an experimental bacterial keratitis model on the corneal collagen cross-linking treatment (CXL), and also to compare topical antibiotic treatment with the combined treatment.The study involved 40 young adult female Sprague Dawley rats, which had a 2 mm scraped defect of the central corneal epithelium in both eyes (...) . The rats were divided into two equal groups. The first group was inoculated in both eyes with standard Pseudomonas Aeruginosa (PA) from a strain suspension prepared from 0.05 ml (Group 1), and the second group was inoculated with standard Methicillin Resistance Staphylococcus Aureus (MRSA) strains from a suspension prepared from 0.05 ml (Group 2). Group 1 was divided into four sub-groups: Group 1A was treated by collagen cross-linking (CXL), Group 1C was treated with topical tobramycin drops CXL

2017 Saudi Journal of Ophthalmology

18. Impact of Topically Administered Steroids, Antibiotics, and Sodium Hyaluronate on Bleb-Related Infection Onset: The Japan Glaucoma Society Survey of Bleb-Related Infection Report 4 Full Text available with Trip Pro

Impact of Topically Administered Steroids, Antibiotics, and Sodium Hyaluronate on Bleb-Related Infection Onset: The Japan Glaucoma Society Survey of Bleb-Related Infection Report 4 To investigate the impact of topically administered ophthalmic medications on the onset and severity of bleb-related infections.Data obtained from 104 eyes of 104 patients with bleb-related infections were analyzed. We assigned an infection stage to each eye (stage 1-4) and analyzed the onset severity.Steroids (...) administration (P = 0.025). Multiple logistic regression analysis revealed that infections were severe in the steroid-administered eyes (odds ratio: 4.57). No infections developed within 16 weeks postoperatively. No relationship was detected between sodium hyaluronate and the analyzed factors.Topical steroid administration beyond the immediate postoperative period may affect severe and earlier onset bleb-related infections. Conversely, topical antibiotic administration may be effective in suppressing earlier

2017 Journal of ophthalmology

19. Topical Antibiotic Prophylaxis for Eyelids

Topical Antibiotic Prophylaxis for Eyelids Topical Antibiotic Prophylaxis for Eyelids - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Topical Antibiotic Prophylaxis for Eyelids The safety and scientific (...) Party): Robert Kersten, University of California, San Francisco Study Details Study Description Go to Brief Summary: The investigators propose a prospective randomized control trial testing the hypothesis that routine topical antibiotic prophylaxis does not significantly reduce the rate of infection after eyelid surgery. Condition or disease Intervention/treatment Phase Antibiotic Side Effect Eyelid; Wound Eyelid Diseases Surgical Wound Infection Surgical Wound, Recent Surgical Incision Skin Cancer

2017 Clinical Trials

20. Topical antibiotics and intravitreal injections. Full Text available with Trip Pro

- and/or postinjection topical antibiotics. This review outlines the general principles of effective antibiotic prophylaxis, and the evidence regarding topical antibiotic use as a prophylactic measure for endophthalmitis following intravitreal injections. A key distinguishing feature of intravitreal injections from most other invasive procedures is the fact that they are often repeated on multiple occasions to the same eye. Given the lack of evidence to support topical antibiotics as an effective method (...) Topical antibiotics and intravitreal injections. There is increasing evidence that topical antibiotics, given before and/or after intravitreal injections, are ineffective in preventing endophthalmitis and are possibly harmful. In addition to the lack of efficacy and increased development of resistant organisms, the use of topical antibiotics adds significantly to the cost of delivering intravitreal therapy. Despite this, in many countries, it is still common practice to use pre

2017 Acta ophthalmologica

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