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Topical Eye Antibiotic

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1. Antibiotics by injection into the eye can prevent severe infection following cataract surgery

the trials of injections into the eyeball were observational. Topical antibiotics were tested in all the randomised trials. There were no trials allowing a direct comparison of antibiotics injected into the eye against each other. What did it find? Nine observational studies found that endophthalmitis was less common after vancomycin or moxifloxacin antibiotic injections into the eye (17 out of 105,003) compared to no injection (156 out of 236,742), (odds ratio [OR] 0.20, 95% confidence interval [CI (...) and moxifloxacin injected inside the eyeball, or under the conjunctiva, or as antibiotic drops applied to the surface of the eye. The results were assessed as moderate to high quality with a low risk of bias. However they were mostly observational studies and these were assessed using a non-standard scale. The authors analysed the data in separate ways to test the variability in results across the studies. All the trials of injections into the eyeball were observational. Topical antibiotics were tested in all

2019 NIHR Dissemination Centre

2. Antibiotics by injection into the eye can prevent severe infection following cataract surgery

the trials of injections into the eyeball were observational. Topical antibiotics were tested in all the randomised trials. There were no trials allowing a direct comparison of antibiotics injected into the eye against each other. What did it find? Nine observational studies found that endophthalmitis was less common after vancomycin or moxifloxacin antibiotic injections into the eye (17 out of 105,003) compared to no injection (156 out of 236,742), (odds ratio [OR] 0.20, 95% confidence interval [CI (...) and moxifloxacin injected inside the eyeball, or under the conjunctiva, or as antibiotic drops applied to the surface of the eye. The results were assessed as moderate to high quality with a low risk of bias. However they were mostly observational studies and these were assessed using a non-standard scale. The authors analysed the data in separate ways to test the variability in results across the studies. All the trials of injections into the eyeball were observational. Topical antibiotics were tested in all

2018 NIHR Dissemination Centre

3. Topical Eye Antibiotic

Topical Eye Antibiotic Topical Eye Antibiotic Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Topical Eye Antibiotic Topical Eye (...) Antibiotic Aka: Topical Eye Antibiotic , Ophthalmic Antibiotic II. Indications Treatment of infection Prophylaxis in (avoid s due to toxicity risk) Chemical Eye Burn III. Preparations: Most cost effective agents First-line Trimethoprim-Polymyxin B (Polytrim) solution 0.5% ointment Broad-spectrum (Gentak) 0.3% ointment or solution Tobramycin (Tobrex) 0.3% solution (ointment is not generic and is expensive) (Ciloxan) 0.3% ointment or solution (Ocuflox) 0.3% solution IV. Preparations: First-Line general

2018 FP Notebook

4. Allergic contact dermatitis from topical ophthalmic medications: keep an eye on it! (PubMed)

clinic; all patients with a positive patch-test reaction to eye medication or its ingredient(s) having caused ACD were studied. For each allergen identified, the number of positive test results compared with the total number of those in the total population, as well as trends across three periods, namely 1990-1998, 1999-2007, and 2008-2016 were studied.118 patients (0.7%) presented with positive patch-test results to ingredients of, and/or topical ophthalmic medications. Aminoglycoside antibiotics (...) Allergic contact dermatitis from topical ophthalmic medications: keep an eye on it! Allergic contact dermatitis (ACD) from topical ophthalmic medications is often overlooked.To study the demographic characteristics, lesion locations, and associated medical conditions of the patients with ACD from ophthalmic drugs, and to identify the most common allergenic culprits, as well as trends in frequencies over the years.From January 1990 until December 2016, 16 065 patients were investigated in our

2019 Contact Dermatitis

5. A diagnosis of late-onset Myasthenia gravis unmasked by topical antibiotics (PubMed)

A diagnosis of late-onset Myasthenia gravis unmasked by topical antibiotics Myasthenia Gravis (MG) is a disorder of the neuromuscular junction (NMJ) that manifests as fluctuating fatiguable weakness of the muscles. There are many factors that can exacerbate myasthenia symptoms including a variety medications and drugs, systemic illness, and pregnancy. A number of medications have been implicated in exacerbating MG symptoms, including aminoglycosides. We present a case of an elderly female (...) with newly diagnosed MG following the use of tobramycin eye drops for 3 days. There have been limited reports in the literature of topical medications that exacerbate MG symptoms. Clinicians prescribing tobramycin eye drops (or other associated medications) should have a high index of suspicion of MG as early discontinuation and therapy will limit long-term morbidity and mortality in these patients.

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2018 Journal of community hospital internal medicine perspectives

6. A randomized controlled trial comparing the efficacy of topical antibiotic steroid combination versus no treatment after fornix-incision strabismus surgery. (PubMed)

A randomized controlled trial comparing the efficacy of topical antibiotic steroid combination versus no treatment after fornix-incision strabismus surgery. To compare comfort and inflammation in patients treated with postoperative topical antibiotic steroids in one eye versus no treatment in the other eye.This prospective, randomized single-masked study included all patients with planned symmetrical strabismus surgery via fornix incision. One eye was randomly assigned to topical postoperative (...) tobramycin-dexamethasone and the other eye was not treated. Patient and parent questionnaires were administered, and two masked observers assessed conjunctival injection over the muscle and wound site.A total of 70 patients completed at least 1 postoperative visit and were included. There was no statistically significant difference between the treatment eye and the no treatment eye in any of the studied parameters.Postoperative topical antibiotic steroid did not prove to be superior to no treatment

2018 JAAPOS - Journal of the American Association for Pediatric Ophthalmology and Strabismus

7. Cost comparison of commonly used postoperative topical ophthalmic antibiotics. (PubMed)

Cost comparison of commonly used postoperative topical ophthalmic antibiotics. To provide information on the actual fill level and cost of currently available antibiotic drops used perioperatively.Prospective laboratory investigation.Robert Cizik Eye Clinic, Houston, Texas USA.The following 9 medications were tested: moxifloxacin, gatifloxacin (branded and generic), besifloxacin, levofloxacin, ciprofloxacin, ofloxacin, trimethoprim/polymyxin B, tobramycin, and gentamicin. Actual bottle-fill (...) . The costs of common postoperative topical antibiotic regimens vary widely depending on the drug and dosing regimen. Cost considerations for perioperative antibiotics will be increasingly important because the number of cataract surgeries is expected to increase with the growing and aging population.Copyright © 2017 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

2017 Journal of cataract and refractive surgery

8. Topical antibiotics and intravitreal injections. (PubMed)

- and/or postinjection topical antibiotics. This review outlines the general principles of effective antibiotic prophylaxis, and the evidence regarding topical antibiotic use as a prophylactic measure for endophthalmitis following intravitreal injections. A key distinguishing feature of intravitreal injections from most other invasive procedures is the fact that they are often repeated on multiple occasions to the same eye. Given the lack of evidence to support topical antibiotics as an effective method (...) Topical antibiotics and intravitreal injections. There is increasing evidence that topical antibiotics, given before and/or after intravitreal injections, are ineffective in preventing endophthalmitis and are possibly harmful. In addition to the lack of efficacy and increased development of resistant organisms, the use of topical antibiotics adds significantly to the cost of delivering intravitreal therapy. Despite this, in many countries, it is still common practice to use pre

2017 Acta ophthalmologica

9. Topical Antibiotic Prophylaxis for Eyelids

Topical Antibiotic Prophylaxis for Eyelids Topical Antibiotic Prophylaxis for Eyelids - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Topical Antibiotic Prophylaxis for Eyelids The safety and scientific (...) Party): Robert Kersten, University of California, San Francisco Study Details Study Description Go to Brief Summary: The investigators propose a prospective randomized control trial testing the hypothesis that routine topical antibiotic prophylaxis does not significantly reduce the rate of infection after eyelid surgery. Condition or disease Intervention/treatment Phase Antibiotic Side Effect Eyelid; Wound Eyelid Diseases Surgical Wound Infection Surgical Wound, Recent Surgical Incision Skin Cancer

2017 Clinical Trials

10. Impact of Topically Administered Steroids, Antibiotics, and Sodium Hyaluronate on Bleb-Related Infection Onset: The Japan Glaucoma Society Survey of Bleb-Related Infection Report 4 (PubMed)

Impact of Topically Administered Steroids, Antibiotics, and Sodium Hyaluronate on Bleb-Related Infection Onset: The Japan Glaucoma Society Survey of Bleb-Related Infection Report 4 To investigate the impact of topically administered ophthalmic medications on the onset and severity of bleb-related infections.Data obtained from 104 eyes of 104 patients with bleb-related infections were analyzed. We assigned an infection stage to each eye (stage 1-4) and analyzed the onset severity.Steroids (...) administration (P = 0.025). Multiple logistic regression analysis revealed that infections were severe in the steroid-administered eyes (odds ratio: 4.57). No infections developed within 16 weeks postoperatively. No relationship was detected between sodium hyaluronate and the analyzed factors.Topical steroid administration beyond the immediate postoperative period may affect severe and earlier onset bleb-related infections. Conversely, topical antibiotic administration may be effective in suppressing earlier

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2017 Journal of ophthalmology

11. Comparison between corneal cross-linking, topical antibiotic and combined therapy in experimental bacterial keratitis model (PubMed)

Comparison between corneal cross-linking, topical antibiotic and combined therapy in experimental bacterial keratitis model This study was conducted to investigate the effects of an experimental bacterial keratitis model on the corneal collagen cross-linking treatment (CXL), and also to compare topical antibiotic treatment with the combined treatment.The study involved 40 young adult female Sprague Dawley rats, which had a 2 mm scraped defect of the central corneal epithelium in both eyes (...) . The rats were divided into two equal groups. The first group was inoculated in both eyes with standard Pseudomonas Aeruginosa (PA) from a strain suspension prepared from 0.05 ml (Group 1), and the second group was inoculated with standard Methicillin Resistance Staphylococcus Aureus (MRSA) strains from a suspension prepared from 0.05 ml (Group 2). Group 1 was divided into four sub-groups: Group 1A was treated by collagen cross-linking (CXL), Group 1C was treated with topical tobramycin drops CXL

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2017 Saudi Journal of Ophthalmology

12. Are Topical Nonsteroidal Anti-Inflammatory Drugs Useful for Analgesia in Patients With Traumatic Corneal Abrasions?

. Therefore, only short courses of topical nonsteroidal anti-inflammatory drugs should be prescribed to patients with corneal abrasion who are able to obtain early follow-up evaluation after ED discharge. Finally, there is currently very limited evidence to suggest the best treatment approach for corneal abrasions other than topical antibiotics initiated the ED. Eye patching x 12 Lim, C.H., Turner, A., and Lim, B.X. Patching for corneal abrasion. Cochrane Database Syst Rev . 2016 ; 26 : CD004764 (...) , the frequency of healing at 24 and 48 hours after injury, whether the use of concurrent topical antibiotics (drops or ointments) with additional lubricating effects reduced pain, and the complications of corneal abrasions through the use of topical nonsteroidal anti-inflammatory drugs versus the control groups. Data Extraction and Synthesis Two reviewers independently assessed the articles for eligibility, performed data extraction, assessed risk of bias by the Cochrane Risk of Bias Tool, x 1 Higgins, J.P

2019 Annals of Emergency Medicine Systematic Review Snapshots

13. Topical Ophthalmic AGN-195263 for the Treatment of Evaporative Dry Eye

), omega-3 supplementation (topical ocular or systemic), or antibiotics (ie, systemic or topical macrolides, tetracyclines, tetracycline derivatives [including doxycycline and minocycline]) for the treatment of dry eye disease, or meibomian gland disease within 1 year of the standardization (day -21) visit Exclusion Criteria: Male patients with a history of, known, or suspected prostate cancer Male patients with a prostate-specific antigen (PSA) level ≥ 4 μg/L Female patients with a history of known (...) Topical Ophthalmic AGN-195263 for the Treatment of Evaporative Dry Eye Topical Ophthalmic AGN-195263 for the Treatment of Evaporative Dry Eye - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Topical

2016 Clinical Trials

14. Topical treatments for blepharokeratoconjunctivitis in children. (PubMed)

Topical treatments for blepharokeratoconjunctivitis in children. Blepharokeratoconjunctivitis (BKC) is a type of inflammation of the surface of the eye and eyelids that involves changes of the eyelids, dysfunction of the meibomian glands, and inflammation of the conjunctiva and cornea. Chronic inflammation of the cornea can lead to scarring, vascularisation and opacity. BKC in children can cause significant symptoms including irritation, watering, photophobia and loss of vision from corneal (...) opacity, refractive error or amblyopia.Treatment of BKC is directed towards modification of meibomian gland disease and the bacterial flora of lid margin and conjunctiva, and control of ocular surface inflammation. Although both topical and systemic treatments are used to treat people with BKC, this Cochrane review focuses on topical treatments.To assess and compare data on the efficacy and safety of topical treatments (including antibiotics, steroids, immunosuppressants and lubricants), alone

2017 Cochrane

15. Endophthalmitis After Intravitreous Anti-VEGF Injections in Patients Receiving vs. Not Receiving Topical Antibiotics

between eyes receiving post-injection antibiotics drops and those not receiving antibiotics drops treated at Chiang Mai University Hospital between May 2015 and April 2017 (2-year period). Condition or disease Intervention/treatment Endophthalmitis Drug: Topical antibiotics following injection Detailed Description: Intravitreous anti-VEGF injection has been the most common procedure performed at eye clinics worldwide. It becomes the gold standard treatment for many macular diseases, such as diabetic (...) . Recently, many large trials from the US including the Diabetic Retinopathy Clinical Research Network (DRCR.net), the Comparison of AMD Treatment Trials (CATT) study have reported the incidence of post-injection endophthalmitis comparing between eyes receiving versus not receiving post-injection antibiotics, and the results of all studies suggested that topical antibiotics does not help reduce the incidence of post-injection endophthalmitis. In addition, the results suggested that eyes receiving

2016 Clinical Trials

16. Effects of Topical Antibiotic Prophylaxis on Wound Healing After Flapless Implant Surgery: A Pilot Study. (PubMed)

Effects of Topical Antibiotic Prophylaxis on Wound Healing After Flapless Implant Surgery: A Pilot Study. The purpose of this pilot study is to investigate the effects of local application of minocycline hydrochloride ointment (MHO) and erythromycin eye ointment (EEO) on wound healing after flapless implant surgery.Forty patients with flapless implant surgery were enrolled and assigned randomly to three groups: 1) MHO group (n = 17); 2) EEO group (n = 18); and 3) control group (n = 5). All (...) of them took systemic antibiotics; the control group did not receive the application of topical antibiotics. Three days after the surgical operation, clinical parameters, peri-implant crevicular fluid volume, and crevicular lipopolysaccharide (LPS) levels of all patients were collected, measured, and analyzed.Clinical outcomes of the two treatment groups were superior to results of the control group, indicating the effectivity of local antibiotics application in promoting early wound healing after

2016 Journal of periodontology

17. Topical Antibiotics

Topical Antibiotics Topical Antibiotics Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Topical Antibiotics Topical Antibiotics Aka (...) : Topical Antibiotics , Bacitracin , Bactroban , Mupirocin From Related Chapters II. Preparations Bacitracin Mupirocin (Bactroban) 2% ointment : Applied three times daily to affected area for 7-10 days May be used in age 2 months and older Available as 22 g tube (ointment is less expensive than creams) Emerging Streptococcal resistance in 2014 ( ) 1% ointment : Apply twice daily to affected area for 5 days May be used in age 9 months and older Treatment area must be <100 cm2 (or <2% total BSA

2018 FP Notebook

18. Elimination of Topical Antibiotics for Intravitreous Injections and the Importance of Using Povidone-Iodine: Update from the Diabetic Retinopathy Clinical Research Network. (PubMed)

Elimination of Topical Antibiotics for Intravitreous Injections and the Importance of Using Povidone-Iodine: Update from the Diabetic Retinopathy Clinical Research Network. This report provides updated endophthalmitis rates for eyes receiving intravitreous injections with and without povidone-iodine and rates with and without topical antibiotics from Diabetic Retinopathy Clinical Research Network clinical trials.Among 8 Diabetic Retinopathy Clinical Research Network clinical trials conducted (...) (0.05% of 11 565 injections) in eyes receiving topical antibiotics and 3 cases (0.02% of 17 208 injections) in eyes not receiving topical antibiotics (P = .17).While only a small number of eyes did not receive povidone-iodine just prior to an intravitreous injection, this report provides further evidence regarding the risk of endophthalmitis when povidone-iodine is not used before intravitreous injections. Exclusion of topical antibiotics was not associated with a higher risk of endophthalmitis

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2016 JAMA ophthalmology

19. Acne - Guidelines for Prescribing Topical Treatment

- possible hormonal issues Onset at age >30 - possible rosacea Widespread distribution of lesions beyond face making topical therapy impractical. Refer to patient's primary care provider as a systemic antibiotic may be warranted. Number and severity of lesions indicates moderate or possibly severe acne: Number of comedones > 20, OR Number of inflammatory lesions (papules, pustules, nodules, or cysts) > 15, OR Total number of lesions > 30 total lesions Family history of scarring acne. Signs (...) Benzoyl peroxide degrades retinoids and antibiotics - administration times must be separated or a combination product used Allow 3 months for improvement. Follow-up with patient to assess effectiveness at 8 weeks. Patient may see initial worsening for the first 2 to 4 weeks. May cause bleaching of hair, clothing, towels, and bedding. Prescription drug options for acne Topical Retinoids (level 1 [likely reliable] evidence) Some guidelines recommend topical retinoids as first line treatment for mild

2018 medSask

20. Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery. (PubMed)

outcomes.Multiple measures for preventing endophthalmitis following cataract surgery have been studied. High-certainty evidence shows that injection with cefuroxime with or without topical levofloxacin lowers the chance of endophthalmitis after surgery, and there is moderate-certainty evidence to suggest that using antibiotic eye drops in addition to antibiotic injection probably lowers the chance of endophthalmitis compared with using injections or eye drops alone. Clinical trials with rare outcomes require (...) Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery. Endophthalmitis is a severe inflammation of the anterior or posterior (or both) chambers of the eye that may be sterile or associated with infection. It is a potentially vision-threatening complication of cataract surgery. Prophylactic measures for endophthalmitis are targeted against various sources of infection.To evaluate the effects of perioperative antibiotic prophylaxis for endophthalmitis following

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2017 Cochrane

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