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Topical Corticosteroid

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1. Corticosteroids - topical (skin), nose, and eyes: Scenario: Intranasal corticosteroid treatment

burning, irritation, ulceration. Systemic adverse effects — these occur rarely, are much less likely to occur than with oral corticosteroids, and are associated with high doses or prolonged treatment. The risk is higher with drops compared with sprays, as they are administered incorrectly more frequently. Systemic adverse effects include: Adrenal suppression — for signs and symptoms of adrenal suppression, see the section on in the CKS topic on . Cushing's syndrome. Decreased bone mineral density (...) Corticosteroids - topical (skin), nose, and eyes: Scenario: Intranasal corticosteroid treatment Scenario: Intranasal corticosteroid treatment | Management | Corticosteroids - topical (skin), nose, and eyes | CKS | NICE Search CKS… Menu Scenario: Intranasal corticosteroid treatment Corticosteroids - topical (skin), nose, and eyes: Scenario: Intranasal corticosteroid treatment Last revised in June 2020 Scenario: Intranasal corticosteroid treatment From birth onwards. What should I consider when

2018 NICE Clinical Knowledge Summaries

2. Home-based narrowband UVB, topical corticosteroid or combination for children and adults with vitiligo: HI-Light Vitiligo three-arm RCT Full Text available with Trip Pro

Home-based narrowband UVB, topical corticosteroid or combination for children and adults with vitiligo: HI-Light Vitiligo three-arm RCT Home-based narrowband UVB, topical corticosteroid or combination for children and adults with vitiligo: HI-Light Vitiligo three-arm RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try (...) a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} A combination of home-based narrowband UVB and topical corticosteroid is superior to topical corticosteroid alone and it was relatively safe and well tolerated. {{author}} {{($index , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , & . Jonathan M Batchelor 1, † , Kim S Thomas 1, *, † , Perways Akram 2 , Jaskiran Azad 3 , Anthony

2020 NIHR HTA programme

3. Seborrhoeic dermatitis: Topical corticosteroids

Seborrhoeic dermatitis: Topical corticosteroids Topical corticosteroids | Prescribing information | Seborrhoeic dermatitis | CKS | NICE Search CKS… Menu Topical corticosteroids Seborrhoeic dermatitis: Topical corticosteroids Last revised in February 2019 Topical corticosteroids For detailed information on prescribing corticosteroids see the CKS topic on . © .

2020 NICE Clinical Knowledge Summaries

4. Corticosteroids - topical (skin), nose, and eyes: Scenario: Topical treatment

effects of oral corticosteroids may also occur with topical corticosteroids, especially in children, including: Adrenal suppression — for signs and symptoms of adrenal suppression, see the section on in the CKS topic on . Cushing's syndrome. Growth suppression. Visual disturbance — if a person presents with symptoms such as blurred vision or other visual disturbances, consider referral to an ophthalmologist for evaluation of possible causes that may include cataract, glaucoma, or rare diseases (...) review Choosing topical corticosteroids [ ], and the summary of product characteristics for Betnovate cream [ ]. Systemic adverse effects An Australasian College of Dermatology consensus statement on the adverse effects of topical corticosteroids in paediatric eczema [ ] states that physiological hypothalamic-pituitary-adrenal (HPA) axis suppression can occur with very widespread and prolonged, or occlusive use of potent/superpotent topical corticosteroids. However, this recovers quickly

2018 NICE Clinical Knowledge Summaries

5. Effects on the Pain of an Infiltration by Acid Hyaluronic Association and Corticoids Versus Only Corticoids in the Rhizarthrosis.

Assessor) Primary Purpose: Treatment Official Title: Effects on the Pain of an Infiltration by Acid Hyaluronic Association and Corticoids Versus Only Corticoids in the Rhizarthrosis. Actual Study Start Date : May 11, 2018 Estimated Primary Completion Date : December 2019 Estimated Study Completion Date : September 2021 Resource links provided by the National Library of Medicine related topics: related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator (...) Effects on the Pain of an Infiltration by Acid Hyaluronic Association and Corticoids Versus Only Corticoids in the Rhizarthrosis. Effects on the Pain of an Infiltration by Acid Hyaluronic Association and Corticoids Versus Only Corticoids in the Rhizarthrosis. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have

2018 Clinical Trials

6. Corticosteroids - topical (skin), nose, and eyes: Scenario: Eye treatment

characteristics state that there is inadequate data to determine the safety of corticosteroid eye preparations in pregnancy [ ; ]. With systemic use of corticosteroids at higher doses, intrauterine growth inhibition and inhibition of the function of the adrenal cortex have been reported, but these effects have not been reported for ocular use [ ]. Topical administration of corticosteroids to pregnant animals can cause abnormalities of fetal development including cleft palate and intrauterine growth (...) with high doses prescribed for prolonged periods. Systemic adverse effects include: Adrenal suppression — for signs and symptoms of adrenal suppression, see the section on in the CKS topic on . Cushing's syndrome. Visual disturbance, central serous chorioretinopathy, cataract, glaucoma. If a person presents with symptoms such as blurred vision or other visual disturbances, consider referral to an ophthalmologist for evaluation. For more information on the systematic adverse effects of corticosteroids

2018 NICE Clinical Knowledge Summaries

7. Corticosteroids - topical (skin), nose, and eyes

Corticosteroids - topical (skin), nose, and eyes Corticosteroids - topical (skin), nose, and eyes | Topics A to Z | CKS | NICE Search CKS… Menu Corticosteroids - topical (skin), nose, and eyes Corticosteroids - topical (skin), nose, and eyes Last revised in June 2020 Corticosteroids are synthetic analogues of the natural hormones that are produced by the adrenal cortex. Management Background information Corticosteroids - topical (skin), nose, and eyes: Summary Corticosteroids are synthetic (...) analogues of the natural hormones that are produced by the adrenal cortex. Local corticosteroids are predominantly glucocorticoids. They have four main effects: Anti-inflammatory. Immunosuppressive. Anti-proliferative (anti-mitotic). Vasoconstrictive. Topical corticosteroids exert these effects on the skin: Eczema — the anti-inflammatory and immunosuppressive effects are important. Psoriasis — is characterized by rapid cell turnover, and the anti-mitotic effects are important. Intranasal corticosteroids

2018 NICE Clinical Knowledge Summaries

8. Scabies: Topical corticosteroids

Scabies: Topical corticosteroids Topical corticosteroids | Prescribing information | Scabies | CKS | NICE Search CKS… Menu Topical corticosteroids Scabies: Topical corticosteroids Last revised in November 2017 Topical corticosteroids Contraindications, adverse effects, dosing information For detailed information on prescribing topical corticosteroids, please see the CKS topic on . © .

2018 NICE Clinical Knowledge Summaries

9. Topical corticosteroids supplemented with topical cyclosporine A versus topical corticosteroids alone for the prevention and treatment of immunological corneal graft rejection: a systematic review and meta-analysis

Topical corticosteroids supplemented with topical cyclosporine A versus topical corticosteroids alone for the prevention and treatment of immunological corneal graft rejection: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD

2020 PROSPERO

10. Corticosteroids - inhaled: Scenario: Corticosteroids - inhaled

through a face mask or nebulizer a steroid rash (reddening and atrophy) may develop on the nose and around the mouth. Systemic adverse effects — these occur rarely and are much less likely to occur than with oral corticosteroids and are associated with high doses and prolonged use. Systemic adverse effects include: Adrenal suppression — for signs and symptoms of adrenal suppression, see the section on in the CKS topic on . Behavioural changes, sleep disorders, depression, aggression (predominantly (...) corticosteroids: Ensure that the dose of inhaled corticosteroid is titrated to the lowest dose at which effective control of symptoms is achieved. If adequate control of symptoms is not achieved, consider using add-on treatments rather than increasing the dose of inhaled corticosteroid. For more information see the CKS topic on . Avoid a rapid reduction in corticosteroid dose after prolonged use to reduce the risk of adrenal insufficiency — in adults who are stable on a high dose, consider halving the dose

2018 NICE Clinical Knowledge Summaries

11. Corticosteroids - oral: Scenario: Corticosteroids

of congenital abnormalities, such as cleft lip/palate. There is no robust evidence to support an association between short-term use of corticosteroids in pregnancy and intra-uterine growth retardation. However, data are limited and do not rule out adverse effects on fetal growth following repeated use, use for extended periods, or use of high-dose corticosteroids. Any adrenal suppression in the neonate following prenatal exposure resolves spontaneously after birth and is rarely clinically important. Monitor (...) . Corticosteroids may also mask the clinical signs of serious systemic disorders and infections until they have progressed to an advanced stage. Clinical manifestation of adrenal insufficiency Adrenal insufficiency is a serious, potentially life-threatening disorder. The presenting symptoms of adrenal insufficiency are non-specific and include: Abdominal pain, nausea, vomiting, diarrhoea. Anorexia and weight loss (and in children, faltering growth). Arthralgia, myalgia. Dizziness. Electrolyte abnormalities

2018 NICE Clinical Knowledge Summaries

12. Assessing the response of morphea and limited scleroderma to tranilast: a small prospective study comparing topical corticosteroids to a combination of topical corticosteroids and tranilast Full Text available with Trip Pro

Assessing the response of morphea and limited scleroderma to tranilast: a small prospective study comparing topical corticosteroids to a combination of topical corticosteroids and tranilast Scleroderma is traditionally managed with immunomodulatory agents such as methotrexate, mycophenolate mofetil and corticosteroids. There are anecdotal reports for, and theoretical reasons why, the anti-fibrotic agent tranilast may provide an additional treatment modality.The objective of the current study (...) was to demonstrate if the addition of topical tranilast to an established regime resulted in an improvement in the Localized Scleroderma Assessment Tool (LoSCAT) and modified Rodnan score.A small double-blinded randomized prospective study of 11 pairs of treatment sites in four patients; three with morphea and one with limited scleroderma was performed. All patients continued with their prescribed treatment and applied 0.1% betamethasone valerate in PCCA PracaSil™ (B) to the control site with 0.1% betamethasone

2018 Clinical, cosmetic and investigational dermatology Controlled trial quality: uncertain

13. Topical 5% Minoxidil and Potent Topical Corticosteroid Versus Intralesional Corticosteroid in the Treatment of Alopecia Areata

Topical 5% Minoxidil and Potent Topical Corticosteroid Versus Intralesional Corticosteroid in the Treatment of Alopecia Areata Topical 5% Minoxidil and Potent Topical Corticosteroid Versus Intralesional Corticosteroid in the Treatment of Alopecia Areata - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. Topical 5% Minoxidil and Potent Topical Corticosteroid Versus Intralesional Corticosteroid in the Treatment of Alopecia Areata The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03535233 Recruitment Status

2018 Clinical Trials

14. Topical Corticosteroids Improve Healing Time in Patients with Aphthous Ulcers

. Applicability The evidence, while of low quality, still supports the application of topical corticosteroids to reduce the healing time of aphthous ulcers. The studies also report a reduction in the occurrence of new ulcers, the size of the ulcers, and the pain experienced by the patient due to the ulcers. A study evaluated in the systematic review shows that topical corticosteroids used intraorally do not cause adrenal suppression, if the patient uses them as instructed. Specialty/Discipline (Oral Medicine (...) Topical Corticosteroids Improve Healing Time in Patients with Aphthous Ulcers UTCAT3273, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Topical Corticosteroids Improve Healing Time in Patients with Aphthous Ulcers Clinical Question In patients with aphthous ulcers, does treatment with topical corticosteroids, as compared to a placebo, improve healing time of the ulcers? Clinical Bottom Line Patients treated

2017 UTHSCSA Dental School CAT Library

15. Different corticosteroid induction regimens in children and young people with juvenile idiopathic arthritis: the SIRJIA mixed-methods feasibility study Full Text available with Trip Pro

Different corticosteroid induction regimens in children and young people with juvenile idiopathic arthritis: the SIRJIA mixed-methods feasibility study Different corticosteroid induction regimens in children and young people with juvenile idiopathic arthritis: the SIRJIA mixed-methods feasibility study Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose (...) a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} A full trial is likely to be feasible to compare different corticosteroid induction regimes, taking account of the views of the children, young people and families when designing a future study. {{author}} {{($index , , , , , , , , , , , , , , & . Ashley P Jones 1 , Dannii Clayton 1 , Gloria Nkhoma 1 , Frances

2020 NIHR HTA programme

16. Interventions for treating oral lichen planus: corticosteroid therapies. (Abstract)

studies evaluated the effectiveness and safety of topical corticosteroids in an adhesive base compared to placebo. We were able to combine two studies in meta-analyses, one evaluating clobetasol propionate and the other flucinonide. We found low-certainty evidence that pain may be more likely to be resolved when using a topical corticosteroid rather than a placebo (RR 1.91, 95% CI 1.08 to 3.36; 2 studies, 72 participants; I² = 0%). The results for clinical effect of treatment and adverse effects were (...) inconclusive (clinical resolution: RR 6.00, 95% CI 0.76 to 47.58; 2 studies, 72 participants; I² = 0%; very low-certainty evidence; adverse effects RR 1.48, 95% 0.48 to 4.56; 3 studies, 88 participants, I² = 0%, very low-certainty evidence). Corticosteroids versus calcineurin inhibitors Three studies compared topical clobetasol propionate versus topical tacrolimus. We found very low-certainty evidence regarding any difference between tacrolimus and clobetasol for the outcomes pain resolution (RR 0.45, 95

2020 Cochrane

17. Inhaled corticosteroids: A rapid review of the evidence for treatment or prevention of COVID-19

the development of acute respiratory distress syndrome. 2 We performed a rapid review of the literature to assimilate the current scientific data on this topic. EMERGING EVIDENCE We searched Medline, Google Scholar and MedRxive on 6 May 2020 for studies that included terms for inhaled corticosteroids and COVID-19 and other related acute coronavirus respiratory tract infections (search strategy provided below). Google Scholar citations were screened until there were 5 consistent pages of citations (...) Inhaled corticosteroids: A rapid review of the evidence for treatment or prevention of COVID-19 Inhaled corticosteroids: A rapid review of the evidence for treatment or prevention of COVID-19 - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website Inhaled corticosteroids: A rapid review of the evidence for treatment or prevention of COVID-19 June 22, 2020 Laura C Armitage and Rachel Brettell On behalf

2020 Oxford COVID-19 Evidence Service

18. Successful management of severe post-LASIK Mycobacterium abscessus keratitis with topical amikacin and linezolid, flap ablation, and topical corticosteroids. Full Text available with Trip Pro

Successful management of severe post-LASIK Mycobacterium abscessus keratitis with topical amikacin and linezolid, flap ablation, and topical corticosteroids. This is a case report of post-laser in situ keratomileusis (LASIK) multidrug-resistant Mycobacterium abscessus keratitis managed with combined topical amikacin and linezolid, flap amputation, and corticosteroids. A 34-year-old woman presented with a corneal interface infiltrate 3 weeks after LASIK. Cultures isolated mycobacteria (...) of the inflammation within 1 week. Identification of the mycobacterial pathogen and its susceptibilities is essential given the possibility of multidrug resistance. Topical linezolid can be effective in susceptible species. Corticosteroids can be helpful in cases with severe inflammation.Copyright © 2019. Published by Elsevier Inc.

2019 Journal of cataract and refractive surgery

19. Topical treatments in atopic dermatitis: unexpectedly low use of emollients; use of topical corticosteroid is higher in juvenile patients, higher in male vs females, and shows independent associations with asthma and depression. Full Text available with Trip Pro

Topical treatments in atopic dermatitis: unexpectedly low use of emollients; use of topical corticosteroid is higher in juvenile patients, higher in male vs females, and shows independent associations with asthma and depression. Despite decades of use,the actual amounts of topical corticosteroids (TCS) and emollients used in moderate-to-severe atopic dermatitis (AD) under real-world conditions are unknown. Thus, it remains unclear if inadequate use is widespread.To quantify the use of TCS (...) contributing to AD severity. TCS use does not exceed current guidelines. Accurate quantification of topical treatments provides a widely accessible strategy to measure real-world impact of novel AD treatments. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.

2019 British Journal of Dermatology

20. Effect of rescue fractional microablative CO2 laser on symptoms and sexual dysfunction in women affected by vulvar lichen sclerosus resistant to long-term use of topic corticosteroid: a prospective longitudinal study. (Abstract)

Effect of rescue fractional microablative CO2 laser on symptoms and sexual dysfunction in women affected by vulvar lichen sclerosus resistant to long-term use of topic corticosteroid: a prospective longitudinal study. The objective of this study was to evaluate the efficacy of rescue fractional microablative CO2 laser treatment in women with severe symptoms and sexual dysfunction related to lichen sclerosus not responsive to long-term ultra-potent topical corticosteroid treatment.Consecutive (...) eligible women with lichen sclerosus referred to our unit who received fractional microablative CO2 laser treatment after failure of ultra-potent topical corticosteroid treatment were enrolled in the study. The diagnosis was confirmed by histological assessment in all cases. Patients underwent two cycles of CO2 laser every 30 to 40 days. The severity of lichen sclerosus-related symptoms, sexual function, and procedure discomfort were evaluated with a visual analog scale in the same individual

2020 Menopause

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